﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Huang, H
   Su, M
   Liu, F
   Long, WB
AF Huang, Heng
   Su, Min
   Liu, Fei
   Long, Wenbo
TI Combination of acupoint herbal plaster and ear acupuncture for effective
   pain relief in patients after laparoscopic appendectomy
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Laparoscopic appendectomy; moxibustion/partitioned moxibustion; ear
   acupuncture; acute appendicitis; analgesia
ID CANCER PAIN; APPENDICITIS; METAANALYSIS; MOXIBUSTION; EFFICACY; POINTS
AB Laparoscopic appendectomy effectively treats appendicitis and other related conditions. However, postoperative pain remains a major concern. This study elucidates the effect of traditional Chinese medicine (TCM) therapies on postoperative recovery of patients who had undergone laparoscopic appendectomy. The study encompassed 262 patients, including 41 controls and 221 TCM-treated patients. Quality control was monitored by two senior TCM physicians and one researcher. Postoperative outcomes included the length of hospitalization, antibiotic use, pain, analgesia and plasma drainage. No significant differences were observed between the groups concerning sex, age, acute appendicitis, postoperative complications and plasma drainage, except for pain and analgesia (both P<0.001). Moxibustion or partitioned moxibustion alone had no effect, compared with the control; however, ear acupuncture alone, acupoint herbal plaster + ear acupuncture, acupoint herbal plaster + moxibustion/partitioned moxibustion and acupoint herbal plaster + ear acupuncture + moxibustion/partitioned moxibustion exerted a significant effect. Pain index and analgesia duration were significantly lower for ear acupuncture alone than in the control group but remained higher than in the three acupoints herbal plaster-treated groups. The combination of acupoint herb plaster and ear acupuncture provided greater pain relief than ear acupuncture alone.
C1 [Huang, Heng; Liu, Fei] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Gen Surg, Hernia & Abdominal Wall Surg, Luzhou 646000, Sichuan, Peoples R China.
   [Su, Min] Southwest Med Univ, Affiliated Hosp, Ophthalmol Dept, Luzhou, Peoples R China.
   [Long, Wenbo] Southwest Med Univ, Affiliated Hosp, Pathol Dept, Luzhou, Peoples R China.
C3 Southwest Medical University; Southwest Medical University; Southwest
   Medical University
RP Long, WB (corresponding author), Southwest Med Univ, Affiliated Hosp, Pathol Dept, Luzhou, Peoples R China.
EM wenbolong@swmu.edu.cn
CR Athanasiou C, 2017, WORLD J SURG, V41, P3083, DOI 10.1007/s00268-017-4123-3
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NR 27
TC 0
Z9 0
U1 5
U2 5
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD JUL-AUG
PY 2025
VL 38
IS 4
DI 10.36721/PJPS.2025.38.4.REG.13887.1
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7GS4K
UT WOS:001570618900003
PM 40824014
OA gold
DA 2026-01-16
ER

PT J
AU Wei, W
   Yao, B
   Sun, XY
   Xing, SN
   Wang, KY
   He, FM
   Xu, QB
   Ren, CX
AF Wei, Wei
   Yao, Bei
   Sun, Xiaoying
   Xing, Shaona
   Wang, Kaiyi
   He, Fangmei
   Xu, Qiaobo
   Ren, Chunxiao
TI Invasive or noninvasive? A systematic review and network meta-analysis
   of acupuncture and acupressure to treat cancer pain
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Acupuncture; Acupressure; Cancer pain; Complementary therapies; Network
   meta-analysis
ID MANAGEMENT; ELECTROACUPUNCTURE; SURVIVORS; EFFICACY; SOCIETY; TRIAL;
   PILOT; WOMEN
AB BackgroundBoth acupressure and acupuncture effectively alleviate pain in cancer patients. Acupuncture requires specialized practitioners and is invasive, while acupressure is noninvasive and can be self-administered. Current comparative evidence remains insufficient for clear clinical recommendations.AimsTo investigate the relative efficacy of acupuncture versus acupressure in alleviating pain among cancer patients.MethodsThis systematic review and network meta-analysis employed a Bayesian framework. Eight major Chinese and English databases were searched from inception to March 1, 2025. Two independent reviewers screened literature, extracted data, and assessed bias in selected studies using the Risk of Bias 2 tool. Network meta-analysis was conducted using R software version 4.4.1.ResultsThirty-seven RCTs including 3066 patients were analyzed to compare eight treatments: manual acupuncture, transcutaneous electrical acupoint stimulation, auricular acupressure, electro-acupuncture, acupoint massage, auricular acupuncture, moxibustion, and placebo. Network meta-analysis revealed auricular acupuncture provided the greatest pain score improvement compared to placebo, followed by auricular acupressure and acupoint massage.ConclusionBased on our analysis, we recommend auricular acupuncture, auricular acupressure, and acupoint massage for managing cancer pain. While current studies demonstrate potential benefits, limitations include concurrent pain medication use and methodological inconsistencies. Future research should include more robust, single-intervention clinical trials to definitively evaluate efficacy for oncology patients.
C1 [Wei, Wei; Sun, Xiaoying; Xing, Shaona; Wang, Kaiyi; He, Fangmei; Xu, Qiaobo; Ren, Chunxiao] Shaanxi Energy Inst, Xianyang 712000, Shaanxi, Peoples R China.
   [Yao, Bei] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Basic Research
   In Clinical Medicine, CACMS
RP Ren, CX (corresponding author), Shaanxi Energy Inst, Xianyang 712000, Shaanxi, Peoples R China.
EM 319068488@qq.com; 1030503107@qq.com; 252230368@qq.com;
   12561895884@qq.com; 1258666562@qq.com; 1481705997@qq.com;
   xuqiaobo@sxny.cn; 2215222801@qq.com
RI sun, xiaoying/AAJ-2725-2021
FU Innovative Team for Smart Healthcare of Geriatric Diseases
   [:2024KYTD06]; Modern TCM Healthcare Technology Demonstration Platform
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by Innovative Team for Smart Healthcare of Geriatric
   Diseases, Approval number:2024KYTD06;Modern TCM Healthcare Technology
   Demonstration Platform,Approval number:2024VCCN-006.
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NR 63
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD OCT 31
PY 2025
VL 33
IS 11
AR 997
DI 10.1007/s00520-025-10068-w
PG 11
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 9ID1U
UT WOS:001606911700002
PM 41171390
DA 2026-01-16
ER

PT J
AU Chen, T
   Zhang, WW
   Chu, YX
   Wang, YQ
AF Chen, Teng
   Zhang, Wen Wen
   Chu, Yu-Xia
   Wang, Yan-Qing
TI Acupuncture for Pain Management: Molecular Mechanisms of Action
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Manual Acupuncture; Electroacupuncture; Pain Modulation; Glial Cells;
   Review
ID RELIEVES NEUROPATHIC PAIN; FLICK TEST DEPENDS; MUSCLE BLOOD-FLOW;
   ELECTROACUPUNCTURE ANALGESIA; INFLAMMATORY PAIN; SPINAL-CORD; RAT MODEL;
   MANUAL ACUPUNCTURE; 100-HZ ELECTROACUPUNCTURE; ANTI-HYPERALGESIA
AB Acupuncture reduces pain by activating specific areas called acupoints on the patient's body. When these acupoints are fully activated, sensations of soreness, numbness, fullness, or heaviness called De qi or Te qi are felt by clinicians and patients. There are two kinds of acupuncture, manual acupuncture and electroacupuncture (EA). Compared with non-acupoints, acupoints are easily activated on the basis of their special composition of blood vessels, mast cells, and nerve fibers that mediate the acupuncture signals. In the spinal cord, EA can inhibit glial cell activation by down-regulating the chemokine CX3CL1 and increasing the anti-inflammatory cytokine interleukin-10. This inhibits P38 mitogenactivated protein kinase and extracellular signal-regulated kinase pathways, which are associated with microglial activation of the C-Jun N-terminal kinase signaling pathway and subsequent astrocyte activation. The inactivation of spinal microglia and astrocytes mediates the immediate and long-term analgesic effects of EA, respectively. A variety of pain-related substances released by glial cells such as the proinflammatory cytokines tumor necrosis factor alpha, interleukin-1 beta, interleukin-6, and prostaglandins such as prostaglandins E2 can also be reduced. The descending pain modulation system in the brain, including the anterior cingulated cortex, the periaqueductal gray, and the rostral ventromedial medulla, plays an important role in EA analgesia. Multiple transmitters and modulators, including endogenous opioids, cholecystokinin octapeptide, 5-hydroxytryptamine, glutamate, noradrenalin, dopamine, gamma-aminobutyric acid, acetylcholine, and orexin A, are involved in acupuncture analgesia. Finally, the "Acupuncture thorn" strategy is introduced to help clinicians achieve better analgesic effects, and a newly reported acupuncture method called acupoint catgut embedding, which injects sutures made of absorbable materials at acupoints to achieve longterm effects, is discussed.
C1 Fudan Univ, Dept Integrat Med & Neurobiol, Brain Sci Collaborat Innovat Ctr,State Key Lab Me, Sch Basic Med Sci,Inst Integrat Med,Inst Brain Sc, Shanghai, Peoples R China.
   Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Chu, YX; Wang, YQ (corresponding author), Fudan Univ, Sch Basic Med Sci, Dept Integrat Med & Neurobiol, 130 Dongan Rd, Shanghai 200032, Peoples R China.
EM yuxiachu@fudan.edu.cn; wangyanqing@shmu.edu.cn
RI Chen, Teng/MSX-8730-2025
OI Chen, Teng/0000-0003-2567-7897
FU National Natural Science Funds of China [81971056, 31600852, 81771202,
   81873101]; Innovative Research Team of High-level Local Universities in
   Shanghai; National Key R&D Program of China [2017YFB0403803]
FX This study was financially supported by the National Natural Science
   Funds of China (81971056, 31600852, 81771202, 81873101), the Innovative
   Research Team of High-level Local Universities in Shanghai, and the
   National Key R&D Program of China (2017YFB0403803).
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NR 100
TC 157
Z9 191
U1 10
U2 116
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 4
BP 793
EP 811
DI 10.1142/S0192415X20500408
PG 19
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA MA3GI
UT WOS:000541805400003
PM 32420752
DA 2026-01-16
ER

PT J
AU Liang, Q
   Zhang, K
   Wang, SM
   Xu, X
   Liu, YQ
   Cui, SY
   Liu, LX
AF Liang, Qi
   Zhang, Ke
   Wang, Sumeng
   Xu, Xian
   Liu, Yiqian
   Cui, Shiyun
   Liu, Lingxiang
TI Acupuncture for Cancer Pain - An Adjuvant Therapy for Cancer Pain Relief
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Cancer Pain; Acupuncture; Pain Management; Review
ID ONCOLOGY ACUPUNCTURE; AROMATASE INHIBITORS; SYMPTOM MANAGEMENT; NECK
   DISSECTION; JOINT SYMPTOMS; BREAST-CANCER; ELECTROACUPUNCTURE; WOMEN;
   ARTHRALGIA; SAFETY
AB As current pain management methods cannot effectively control pain among cancer patients, acupuncture has developed as an adjuvant therapy for cancer pain relief. However, the efficacy of acupuncture in treating cancer pain remains controversial. Here, we briefly introduced the development of pain management, analgesic mechanisms, and acupuncture methods. Meanwhile, a comprehensive overview of acupuncture programs was provided in terms of different cancer types, sources, and degrees. Interestingly, acupuncture can treat both tumor-induced pain and therapy-induced pain well among cancer patients. We preliminarily summarized frequently-used acupoints for different types of cancer pain and found that needle retention time was mostly 30 min, and treatment cycle was two weeks. Additionally, clinicians consistently selected Ashi acupoint or bilateral Zusanli acupoint and combined multiple acupuncture methods for different degrees of cancer pain.
C1 [Liang, Qi; Zhang, Ke; Wang, Sumeng; Xu, Xian; Liu, Yiqian; Cui, Shiyun; Liu, Lingxiang] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
C3 Nanjing Medical University
RP Liu, LX (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
EM llxlau@163.com
RI Li, Tiansuo/OGP-8341-2025; Liu, Lingxiang/I-7538-2016
FU National Natural Science Foundation of China [81472782]; National Key
   Research and Development Program: The key technology of palliative care
   and nursing for cancer patients [2017YFC1309201]
FX This study was supported by National Natural Science Foundation of China
   (81472782) and the National Key Research and Development Program: The
   key technology of palliative care and nursing for cancer patients
   (2017YFC1309201).
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TC 23
Z9 25
U1 9
U2 89
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 8
BP 1769
EP 1786
DI 10.1142/S0192415X20500883
PG 18
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA PQ9IY
UT WOS:000606856300003
PM 33300479
DA 2026-01-16
ER

PT J
AU Faria, M
   Teixeira, M
   Pinto, MJ
   Sargento, P
AF Faria, Miguel
   Teixeira, Monica
   Pinto, Maria Joao
   Sargento, Paulo
TI Efficacy of acupuncture on cancer pain: A systematic review and
   meta-analysis
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Review
DE Acupuncture; Cancer pain; Meta-analysis; Systematic review
ID GASTRIC-CANCER; MANAGEMENT; WOMEN; ELECTROACUPUNCTURE; ANALGESIA;
   SYMPTOMS
AB Background: Pain associated with cancer is one of the greatest causes of reduced quality of life in patients. Acupuncture is one of the treatments used to address this issue, with the great advantage of having little or no side effects, especially when compared with pharmacological pain -killers. Objective: The aim of this systematic review and meta -analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain. Search strategy: Six electronic databases (PubMed, EBSCO, Cochrane Library, Scielo, b -On and Scopus) were searched for relevant articles about pain relief in cancer patients from their beginning until 2022 using MeSH terms such as "acupuncture," "electroacupuncture," "ear acupuncture," "acupuncture analgesia," "oncological pain," and "cancer pain." Inclusion criteria: Studies included were randomized controlled trials (RCTs) where acupuncture was compared with no treatment, placebo acupuncture or usual care. Data extraction and analysis: Three independent reviewers participated in data extraction and evaluation of risk of bias, and a meta -analysis was conducted. The primary outcome was pain intensity, measured with the visual analog scale, numeric rating scale, or brief pain inventory. Secondary outcomes also assessed were quality of life, functionality, xerostomia, pain interference, and analgesic consumption. Results were expressed as standardized mean difference (SMD) with 95% confidence interval (CI). Results: Sixteen RCTs with a total of 1124 participants were included in the meta -analysis, with the majority of the studies presenting a low or unclear risk of bias. Acupuncture was more effective in reducing pain than no treatment (SMD = -0.90, 95 % CI [-1.68, -0.12]), sham acupuncture (SMD = -1.10, 95 % CI [-1.59, -0.61]) or usual care (SMD = -1.16, 95 % CI [-1.38, -0.93]). Conclusion: The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with cancer. Despite some limitations due to the low quality and small sample size of some included studies, as well as the different types and stages of cancer, acupuncture might provide an effective and safe treatment to reduce cancer pain. Please cite this article as: Faria M, Teixeira M, Pinto MJ, Sargento P. Efficacy of acupuncture on cancer pain: A systematic review and meta -analysis. J Integr Med . 2024; 22(3): 235-244. (c) 2024 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights reserved.
C1 [Faria, Miguel; Teixeira, Monica; Sargento, Paulo] Inst Politecn Lusofonia, Nucleo Invest Ciencias & Tecnol Saude, P-1950396 Lisbon, Portugal.
   [Faria, Miguel] Clin Sao Joao Deus, P-1700048 Lisbon, Portugal.
   [Teixeira, Monica] Inst Politecn Porto, Inst Super Engn, Rede Quim & Tecnol Lab Associado Quim Verde, REQUIMTE LAQV, P-4051401 Porto, Portugal.
   [Pinto, Maria Joao] Hosp SOERAD, P-2560312 Torres Vedras, Portugal.
   [Sargento, Paulo] Ctr Estudos Avancados Direito Francisco Suarez, P-1749024 Lisbon, Portugal.
C3 Instituto Politecnico do Porto
RP Faria, M (corresponding author), Inst Politecn Lusofonia, Nucleo Invest Ciencias & Tecnol Saude, P-1950396 Lisbon, Portugal.; Faria, M (corresponding author), Clin Sao Joao Deus, P-1700048 Lisbon, Portugal.
EM miguel.faria@ipluso.pt
RI Teixeira, Mónica/AFT-7797-2022; Faria, Miguel/R-5133-2019
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NR 47
TC 13
Z9 16
U1 6
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAY
PY 2024
VL 22
IS 3
BP 235
EP 244
DI 10.1016/j.joim.2024.03.002
EA MAY 2024
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA UD4U1
UT WOS:001246118300001
PM 38493063
DA 2026-01-16
ER

PT J
AU Xie, TL
   Liu, C
   Wu, YD
   Li, XX
   Yang, QY
   Tan, J
AF Xie, Tianle
   Liu, Can
   Wu, Yudi
   Li, Xiuxiu
   Yang, Qianyun
   Tan, Jing
TI Efficacy and Safety of Different Acupuncture Treatments for
   Cancer-Related Pain: A Systematic Review and Network Meta-Analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; cancer; cancer pain; meta-analysis
ID ELECTROACUPUNCTURE; MOXIBUSTION; THERAPY
AB Background: Cancer pain is a prevalent and persistent issue, and while there have been some observations of the possible benefits of acupuncture in managing cancer pain, there is still debate regarding its safety and effectiveness. This study aims to compare the efficacy and safety of different acupuncture modalities in the treatment of cancer pain through a network meta-analysis. Methods: Between the time each database was created and June 3, 2024, eight databases were queried: PubMed, Cochrane, Embase, Web of Science, CNKI, Wanfang, VIP, and China Biomedicine. Randomized controlled trials investigating the use of various acupuncture and moxibustion techniques in the treatment of cancer pain were identified. Publication bias and quality of randomized controlled trials were assessed using the Cochrane Risk of Bias tool and the Jadad scale, and network meta-analyses were performed using Stata 15 and R 4.3.2. Results: We incorporated 111 studies encompassing 9549 individuals diagnosed with cancer, examining 29 distinct therapies. Network meta-analysis showed that, compared to Usual Medicine, Acupuncture + Usual Medicine + Traditional Chinese medicine (MD = -1.83, 95% CI: -2.86 to -0.80) could reduce NRS scores, Acupuncture + Traditional Chinese medicine (OR = 30.86, 95% CI: 3.75-254.20) could improve cancer pain relief, Moxibustion + Usual Medicine (MD = 2.12, 95% CI: 0.43-3.80) could effectively improve KPS score, Acupuncture + Application of Chinese medicine (OR = 0.16, 95% CI: 0.04-0.66) is associated with a lower incidence of constipation, Electro-Acupuncture + Usual Medicine (OR = 0.11, 95% CI: 0.03-0.45) shows a lower incidence of nausea and vomiting, Acupuncture + Moxibustion + Usual Medicine (OR = 0.29, 95% CI: 0.09-0.90) is associated with a lower incidence of dizziness. Conclusion: Acupuncture + Traditional Chinese medicine is the best intervention for different acupuncture methods in the treatment of cancer pain, and Moxibustion + Usual Medicine is the best intervention to improve the quality of life of patients.
C1 [Xie, Tianle; Liu, Can; Wu, Yudi; Li, Xiuxiu; Yang, Qianyun; Tan, Jing] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
C3 Hunan University of Chinese Medicine
RP Tan, J (corresponding author), Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Clin Applicat & Mech Acupuncture, Hanpu Campus, Changsha 410208, Hunan, Peoples R China.
EM hugotan0101@163.com
RI Liu, Can/OVZ-0523-2025
FU national outstanding youth science fund project of national natural
   science foundation of china [82205296]; Natural Science Foundation of
   China Youth Project [2022JJ1531]; Natural Science Foundation of Hunan
   Province Youth Project [21B0380]; Hunan Provincial Department of
   Education Scientific Research Outstanding Youth Project [S202310541034,
   2020XJJJ008]; Innovation and Entrepreneurship Training Program for
   College Students in Hunan Province
FX The authors thank the financial support of the Natural Science
   Foundation of China Youth Project [No. 82205296], Natural Science
   Foundation of Hunan Province Youth Project [No. 2022JJ1531], Hunan
   Provincial Department of Education Scientific Research Outstanding Youth
   Project [No. 21B0380], Innovation and Entrepreneurship Training Program
   for College Students in Hunan Province [No. S202310541034, No.
   2020XJJJ008].
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NR 133
TC 4
Z9 4
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2025
VL 24
AR 15347354251314500
DI 10.1177/15347354251314500
PG 17
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA T9T4Q
UT WOS:001408342500001
PM 39873173
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, QY
   Yang, WX
   Liu, H
   Jiao, LJ
   Gong, YB
   Shi, J
AF Li, Quan-yao
   Yang, Wen-xiao
   Liu, Hui
   Jiao, Li-Jing
   Gong, Ya-bin
   Shi, Jun
TI Research on Electroacupuncture Parameters for Cancer Pain Based on Data
   Mining
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE cancer pain; electroacupuncture; parameter; data mining; traditional
   Chinese medicine
ID BETA-ENDORPHIN; ELECTRICAL-STIMULATION; ACUPUNCTURE POINTS; TRIGGER
   POINTS; MANAGEMENT; RELEASE; SOCIETY
AB Background:Cancer pain, a common complication of this disease, has been widely treated by electroacupuncture in recent years. However, there are numerous treatment parameters that are not conducive to clinical translation applications. This study aims to summarize the stimulation parameters commonly used in electroacupuncture treating cancer pain by data mining and visualization techniques to provide a basis for the future acupuncture technology transformation and selection of optimal stimulation parameters. Methods:Nine databases, including Pubmed, Cochrane Library, Embase, Web of Science, OVID, China National Knowledge Infrastructure Database, China Biology Medicine disk, China Science and Technology Journal Database, and Wanfang Database, were searched for clinical studies on electroacupuncture treatment cancer pain published between January 2012 and September 2022. A database was established using Microsoft Excel 2020 and analyzed with SPSS Modeler 18.1 software and SPSS statistics 26.0 software. Results:Twenty-four articles were included according to the established criteria. The most used electroacupuncture stimulation parameters were a dilatational wave, the current frequency of 2/100 Hz, stimulation duration of 30 minutes per treatment, and frequency of treatment once a day. Fifty-eight acupoints were mentioned, and the total frequency of acupoints involved was 156 times. The most used ones include Zusanli (ST36), Sanyinjiao (SP06), Hegu (LI04), Neiguan (PC06), Quchi (LI11), Taichong (LR03), Ashi point, Jiaji point, and those most generally used acupoints that are closely arranged on the Stomach Channel of Foot Yangming and the Spleen Channel of Foot Taiyin. The association analysis of acupoints revealed that the most supported acupoint pair was Sanyinjiao (SP06) and Zusanli (ST36). Cluster analysis demonstrated 3 groups, 1 for obligatory acupoints, 1 for Ashi point, and the third for Jiaji point. Conclusions:A dilatational wave, the current frequency of 2/100 Hz, 30-minute stimulation, and acupoints of the Stomach Channel of Foot Yangming and the Spleen Channel of Foot Taiyin selection are frequently used in electroacupuncture for treating cancer pain. Due to the limitations of this study, further research and more standardized, multi-center, large-sample clinical trials can be carried out to guide optimizing acupuncture treatment schemes and promote the formation of TCM-characteristic technologies for cancer pain.
C1 [Li, Quan-yao; Yang, Wen-xiao; Liu, Hui; Jiao, Li-Jing; Gong, Ya-bin; Shi, Jun] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Oncol, Shanghai, Peoples R China.
   [Shi, Jun] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Oncol, 110 GanHe Rd HongKou Dist, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Shi, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Oncol, 110 GanHe Rd HongKou Dist, Shanghai 200437, Peoples R China.
EM shijundoctor@163.com
RI ; Li, Quanyao/PFZ-4523-2026; Gong, Yabin/MTG-1222-2025
OI 刘, LIUHUI/0000-0002-9863-3345; Li, Quanyao/0000-0002-1496-9221; 
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NR 60
TC 6
Z9 6
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231192017
DI 10.1177/15347354231192017
PG 13
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA O4UH4
UT WOS:001043775500001
PM 37551854
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Alimi, D
AF Alimi, David
TI Xerostomia induced by radiotherapy
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Letter
ID AURICULAR ACUPUNCTURE; EAR ACUPUNCTURE; CANCER PAIN
C1 [Alimi, David] Univ Pittsburgh, Med Ctr, Dept Anesthesiol, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Alimi, D (corresponding author), Univ Pittsburgh, Dept Anesthesiol, Pittsburgh, PA 15260 USA.
EM davalimi7@gmail.com
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U1 0
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PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2015
VL 11
BP 1149
EP 1152
DI 10.2147/TCRM.S88021
PG 4
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA CO7CN
UT WOS:000359315200001
PM 26347207
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lyu, ZX
   Guo, YM
   Gong, YA
   Fan, W
   Dou, BM
   Li, NC
   Wang, SJ
   Xu, Y
   Liu, YY
   Chen, B
   Guo, Y
   Xu, ZF
   Lin, XW
AF Lyu, Zhongxi
   Guo, Yongming
   Gong, Yinan
   Fan, Wen
   Dou, Baomin
   Li, Ningcen
   Wang, Shenjun
   Xu, Yuan
   Liu, Yangyang
   Chen, Bo
   Guo, Yi
   Xu, Zhifang
   Lin, Xiaowei
TI The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated
   Central Sensitization in Acupuncture Analgesia
SO NEURAL PLASTICITY
LA English
DT Review
ID SPINAL-CORD ASTROCYTES; RELIEVES NEUROPATHIC PAIN; PERIPHERAL-NERVE
   INJURY; BONE CANCER PAIN; INFLAMMATORY PAIN; DORSAL-HORN;
   ELECTROACUPUNCTURE ANALGESIA; GLUTAMATE TRANSPORTERS; MECHANICAL
   ALLODYNIA; RECEPTOR ANTAGONISTS
AB Although pain is regarded as a global public health priority, analgesic therapy remains a significant challenge. Pain is a hypersensitivity state caused by peripheral and central sensitization, with the latter considered the culprit for chronic pain. This study summarizes the pathogenesis of central sensitization from the perspective of neuroglial crosstalk and synaptic plasticity and underlines the related analgesic mechanisms of acupuncture. Central sensitization is modulated by the neurotransmitters and neuropeptides involved in the ascending excitatory pathway and the descending pain modulatory system. Acupuncture analgesia is associated with downregulating glutamate in the ascending excitatory pathway and upregulating opioids, ?-aminobutyric acid, norepinephrine, and 5-hydroxytryptamine in the descending pain modulatory system. Furthermore, it is increasingly appreciated that neurotransmitters, cytokines, and chemokines are implicated in neuroglial crosstalk and associated plasticity, thus contributing to central sensitization. Acupuncture produces its analgesic action by inhibiting cytokines, such as interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, and upregulating interleukin-10, as well as modulating chemokines and their receptors such as CX3CL1/CX3CR1, CXCL12/CXCR4, CCL2/CCR2, and CXCL1/CXCR2. These factors are regulated by acupuncture through the activation of multiple signaling pathways, including mitogen-activated protein kinase signaling (e.g., the p38, extracellular signal-regulated kinases, and c-Jun-N-terminal kinase pathways), which contribute to the activation of nociceptive neurons. However, the responses of chemokines to acupuncture vary among the types of pain models, acupuncture methods, and stimulation parameters. Thus, the exact mechanisms require future clarification. Taken together, inhibition of central sensitization modulated by neuroglial plasticity is central in acupuncture analgesia, providing a novel insight for the clinical application of acupuncture analgesia.
C1 [Lyu, Zhongxi; Guo, Yongming; Gong, Yinan; Fan, Wen; Dou, Baomin; Li, Ningcen; Wang, Shenjun; Xu, Yuan; Liu, Yangyang; Chen, Bo; Guo, Yi; Xu, Zhifang; Lin, Xiaowei] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China.
   [Lyu, Zhongxi; Guo, Yongming; Wang, Shenjun; Xu, Yuan; Liu, Yangyang; Chen, Bo; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, Tianjin 301617, Peoples R China.
   [Lyu, Zhongxi; Guo, Yongming; Wang, Shenjun; Xu, Yuan; Liu, Yangyang; Chen, Bo; Guo, Yi; Xu, Zhifang; Lin, Xiaowei] Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin 300381, Peoples R China.
   [Fan, Wen] Suzuka Univ Med Sci, Suzuka 5100293, Japan.
   [Guo, Yi; Lin, Xiaowei] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Suzuka University of Medical Science;
   Tianjin University of Traditional Chinese Medicine
RP Xu, ZF; Lin, XW (corresponding author), Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China.; Xu, ZF (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, Tianjin 301617, Peoples R China.; Xu, ZF; Lin, XW (corresponding author), Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin 300381, Peoples R China.; Lin, XW (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM 1025117807@qq.com; guoymxr@163.com; 1457907206@qq.com; 452181040@qq.com;
   1624528149@qq.com; 517654179@qq.com; shenjunwang@163.com;
   xuyuan_87@sina.com; lyy02211@163.com; tjutcmchenbo@163.com;
   guoyi_168@163.com; xuzhifangmsn@hotmail.com; linxiaoweiwqhz@163.com
RI Chen, Bo/C-9818-2012; Gong, Yinan/LWM-9133-2024; Xu,
   Zhifang/AAF-4798-2019
OI Chen, Bo/0000-0003-2420-4764; WEN, FAN/0000-0003-2583-2359; Xu,
   Zhifang/0000-0002-0576-163X; Liu, Yang-yang/0000-0002-9955-0971
FU National Key R&D Program of China [2019YFC1709003]; National Natural
   Science Foundation of China (NSFC) [81704146, 81873369, 81873368];
   Natural Science Foundation of Tianjin [20JCQNJC00280]
FX This study was financially supported by the National Key R&D Program of
   China No. 2019YFC1709003; the National Natural Science Foundation of
   China (NSFC) No. 81704146, 81873369, and 81873368; the Natural Science
   Foundation of Tianjin No. 20JCQNJC00280.
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NR 146
TC 48
Z9 62
U1 7
U2 55
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PD JAN 18
PY 2021
VL 2021
AR 8881557
DI 10.1155/2021/8881557
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA QE4NJ
UT WOS:000616183900001
PM 33531894
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, T
   Zhang, Q
   Zhu, PY
   Sun, WD
   Ding, ZQ
   Hu, L
AF Zhang, Teng
   Zhang, Qiang
   Zhu, Peiye
   Sun, Weidong
   Ding, Zaiqiao
   Hu, Lu
TI The Efficacy of Acupuncture in the Treatment of Chemotherapy-Induced
   Peripheral Neuropathy: A Network Meta-Analysis
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID CLINICAL-PRACTICE GUIDELINES; ELECTROACUPUNCTURE; INTERVENTIONS;
   MECHANISMS; PREVENTION; ANALGESIA; PAIN
AB Background center dot Chemotherapy-induced peripheral neuropathy (CIPN), one of the most common adverse events associated with chemotherapy, may affect efficacy because of the interruption of chemotherapy or change of regimen in severe cases, and may even increase cancer mortality. Relevant data supports the evidence that acupuncture can treat pain and sensory abnormalities. However, choosing the most effective acupuncture therapy is difficult because of the lack of evidence-based medicine and comparisons between different acupuncture therapies for treating CIPN. The aim of this study was to use a network meta-analysis (NMA) to evaluate the efficacy of different acupuncture therapies for CIPN.
   Methods center dot We searched Embase, PubMed, Web of Science, The Cochrane Library, The Chinese Journal Full Text Database, Chinese Biomedical Literature Database, and WanFang Database for randomized controlled trials (RCTs) of acupuncture for CIPN. The search period was from the creation of the relevant library to August 10, 2023. A total of 2 investigators independently performed literature screening, data extraction, and risk for bias evaluation. Stata 14.0 software (StataCorp LLC, College Station, Texas USA), was used for the NMA.
   Results center dot A total of 13 eligible RCTs involving 746 patients and 6 acupuncture therapies were included in the study. The NMA results showed that electroacupuncture was superior to moxibustion, manual acupuncture, acupoint injection and Western medicine in improving the total effective rate of treatment of CIPN; electroacupuncture + moxibustion was better than manual acupuncture, acupoint injection, and Western medicine. Manual acupuncture's total effective rate was better than Western medicine. However, electroacupuncture was the most effective treatment for CIPN according to the surface under the cumulative ranking curve (SUCRA) ranking.
   Conclusion center dot After a comprehensive evaluation of 6 acupuncture therapies for treating CIPN based on NMA, electroacupuncture may be the best option for treating CIPN. However, would be more convincing to get evidence from more RCTs.
C1 [Zhang, Teng; Sun, Weidong] Dazhou Vocat & Tech Coll, Dept Clin Med, Dazhou, Sichuan, Peoples R China.
   [Zhang, Qiang; Ding, Zaiqiao; Hu, Lu] Army Med Ctr PLA, Dept Oncol, Chongqing, Peoples R China.
   [Zhu, Peiye] Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing, Peoples R China.
C3 Army Medical University; Chongqing University of Technology
RP Ding, ZQ; Hu, L (corresponding author), Army Med Ctr PLA, Dept Oncol, Chongqing, Peoples R China.
EM dingzaiqiao@163.com; hulumeier2023@163.com
RI ; Zhang, Qiang/IWU-5000-2023
OI Sun, Wei-Dong/0009-0005-2981-4176; 
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NR 61
TC 6
Z9 7
U1 1
U2 9
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD NOV-DEC
PY 2023
VL 29
IS 8
BP 898
EP 906
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EG1E0
UT WOS:001137669200149
PM 37708563
DA 2026-01-16
ER

PT J
AU Ling, FY
   Qi, WC
   Li, X
   Zhou, J
   Xiong, J
   Zhao, Y
   Zheng, QH
   Liang, FR
AF Ling, Fayang
   Qi, Wenchuan
   Li, Xiao
   Zhou, Jun
   Xiong, Jian
   Zhao, Yi
   Zheng, Qianhua
   Liang, Fanrong
TI Bibliometric Analysis of Acupuncture Therapy for Cancer Pain Over the
   Past 10 Years
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
ID INDUCED PERIPHERAL NEUROPATHY; INHIBITOR-INDUCED ARTHRALGIA;
   BREAST-CANCER; NERVE STIMULATION; MULTIPLE-MYELOMA; AMERICAN SOCIETY;
   DOUBLE-BLIND; HOT FLASHES; ELECTROACUPUNCTURE; CHEMOTHERAPY
AB Purpose: Cancer pain is a common symptom of cancer patients and greatly affects quality of life. Acupuncture has certain curative effects on cancer pain. The aim of this study was to analyze and visualize the current status and research trend of acupuncture treatment for cancer pain over the last 10 years and provide directions for future development. Methods: A search of the Web of Science Core Collection from 2012-01-01 to 2022-08-20 was performed to collect studies related to acupuncture therapy for cancer pain. CiteSpace was used to conduct bibliometric analysis and visualization from the perspective of the volume of annual publications, journals, nations, institutions, authors, keywords, and references. Results: A total of 302 studies were included in the analysis. The number of publications increased steadily with some fluctuations over the past decade. Integrative Cancer Therapies was the journal with the most relevant publications, and the Journal of Clinical Oncology was the most frequently cited journal. China had the highest volume of publications, and the USA contributed most to international collaboration. The most prolific institution was Memorial Sloan Kettering Cancer Center. The most productive author was Mao JJ, and the most influential author was Lu WD. "Acupuncture" was the top keyword in frequency and centrality. The references with the highest frequency and centrality were published by HE, Y, and Ting Bao, respectively. Conclusion: A stable development trend has formed in this field. The overall collaborative network needs to be strengthened. Breast cancer and multiple myeloma, electroacupuncture and bee venom acupuncture, postoperative pain, peripheral neuropathic pain syndrome, and aromatase inhibitors-associated arthralgia syndrome are research hotspots in this field. Randomized controlled trials (RCTs), evidence-based evaluations and mechanisms (cancer-induced bone pain) are research trends and frontiers. Keywords: acupuncture analgesia, cancer, pain, bibliometric analysis, CiteSpace
C1 [Ling, Fayang; Qi, Wenchuan; Li, Xiao; Zhou, Jun; Xiong, Jian; Zhao, Yi; Zheng, Qianhua] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
   [Liang, Fanrong] Chengdu Univ Tradit Chinese Med, Clin Res Ctr Acupuncture & Moxibust Sichuan Prov, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Zheng, QH (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.; Liang, FR (corresponding author), Chengdu Univ Tradit Chinese Med, Clin Res Ctr Acupuncture & Moxibust Sichuan Prov, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
EM acuresearch@126.com; zhengqianhua@cdutcm.edu.cn
RI 周, 俊/ISS-4050-2023; Qi, Wenchuan/GXG-9496-2022; Xiong,
   Jian/AAN-4124-2020
OI Xiong, Jian/0000-0002-8346-178X; Li, Xiao/0000-0002-2487-9617
FU National Natural Science Foundation of China [U21A20404]; General
   Program of the National Natural Science Foundation of China [82074556]
FX Funding This study was supported by the National Natural Science
   Foundation of China (No. U21A20404) and the General Program of the
   National Natural Science Foundation of China (No. 82074556) .
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NR 110
TC 14
Z9 17
U1 2
U2 42
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 985
EP 1003
DI 10.2147/JPR.S395421
PG 19
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA A0BC5
UT WOS:000951854900001
PM 36968762
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, FQ
   Zhao, JN
   Li, YJ
   Yang, X
   Wu, D
   Yang, B
   Zhang, CK
   He, ZX
   Du, L
   Zhu, XD
   Ming, D
   Liu, Y
   Tang, DX
AF Wang, Feiqing
   Zhao, Jianing
   Li, Yanju
   Yang, Xu
   Wu, Dan
   Yang, Bo
   Zhang, Chike
   He, Zhixu
   Du, Liang
   Zhu, Xiaodong
   Ming, Dong
   Liu, Yang
   Tang, Dongxin
TI Acupuncture and acupressure with improved cancer-related depression of
   retrospective studies
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE acupuncture; acupressure; acupoints; cancer; tumor; oncology; depression
ID QUALITY-OF-LIFE; CLINICAL-TRIALS; PLACEBO; ANXIETY; INSTRUMENT;
   MORTALITY; NOCEBO; CARE; PAIN
AB IntroductionAcupuncture and acupressure are widely used for treating cancer pain and depression and recognized as safe and effective by the international medical community. In this study, we systematically evaluated the efficacy, safety, and clinical significance of acupuncture and acupressure in treating cancer-related depression. MethodsWe searched MEDLINE, PubMed, Science Direct, Google Scholar, Web of Science and Embase and Chinese-language databases for randomized clinical trials (RCTs). To assess efficacy, rating scales administered by clinicians or experts were preferred, including the Hamilton Depression Rating Scale (HAMD), Self-rating Depression Scale (SDS), Self-rating Anxiety Scale (SAS), and Quality of Life Questionnaire-Core 30 (QLQ-C30) and the total effective rate after treatment. In all, Sixteen RCTs involving 1019 cancer patients were included in the Meta-analysis. ResultsEleven (69%) of these studies reported the post-treatment total effective rate. Three hundred fifty-three patients received antidepressants; the total effective rate was 72.5%. Three hundred sixty-one patients underwent acupuncture and acupressure; the total effective rate was 90%. Meta-analysis results showed I-2 = 0%, no heterogeneity, (Z = 5.84, p < 0.00001); and combined OR = 3.55, (95% CI = 2.32 to 5.43). DiscussionThis study found that acupuncture and acupressure are as effective as medication in the treatment of cancer-related depression, provide a reliable basis for the clinical use of acupuncture to treat cancer-related depression, help promote nonpharmacological treatment for cancer-related complications. These approaches thus help reduce drug resistance and adverse reactions and improve patients' quality of life.
C1 [Wang, Feiqing; Zhao, Jianing; Yang, Xu; Wu, Dan; Yang, Bo; Liu, Yang; Tang, Dongxin] Guizhou Univ Tradit Chinese Med, Clin Med Res Ctr, Affiliated Hosp 1, Guiyang, Guizhou, Peoples R China.
   [Wang, Feiqing; Zhu, Xiaodong; Ming, Dong] Tianjin Univ, Acad Med Engn & Translat Med, Tianjin, Peoples R China.
   [Li, Yanju; Zhang, Chike; He, Zhixu] Guizhou Med Univ, Dept Hematol Oncol, Affiliated Hosp, Guiyang, Guizhou, Peoples R China.
   [He, Zhixu; Liu, Yang] Guizhou Med Univ, Chinese Acad Med Sci, Key Lab Adult Stem Cell Translat Res, Guiyang, Guizhou, Peoples R China.
   [Du, Liang] Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Peoples R China.
   [Zhu, Xiaodong] Tianjin Med Univ, Gen Hosp, Neurol Inst, Tianjin, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Tianjin University;
   Guizhou Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Guizhou Medical University; Sichuan University;
   Tianjin Medical University
RP Liu, Y; Tang, DX (corresponding author), Guizhou Univ Tradit Chinese Med, Clin Med Res Ctr, Affiliated Hosp 1, Guiyang, Guizhou, Peoples R China.; Zhu, XD; Ming, D (corresponding author), Tianjin Univ, Acad Med Engn & Translat Med, Tianjin, Peoples R China.; Liu, Y (corresponding author), Guizhou Med Univ, Chinese Acad Med Sci, Key Lab Adult Stem Cell Translat Res, Guiyang, Guizhou, Peoples R China.; Zhu, XD (corresponding author), Tianjin Med Univ, Gen Hosp, Neurol Inst, Tianjin, Peoples R China.
EM zxdtju@163.com; mindtju@126.com; ly7878@163.com; tangdongxintcm@163.com
RI Liu, Yang/ADE-6550-2022; Zhao, Jianing/JRY-2106-2023; Ming,
   Dong/G-8786-2011
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NR 66
TC 7
Z9 12
U1 3
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD DEC 12
PY 2022
VL 12
AR 1036634
DI 10.3389/fonc.2022.1036634
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 7F5XT
UT WOS:000901920700001
PM 36578922
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, XY
   Shen, QY
   Hu, XY
   Yu, XS
   Erasmus, SR
   Gong, LY
   Liu, JH
   Fan, W
   Liang, Y
AF Wang, Xiaoying
   Shen, Qiongying
   Hu, Xinyi
   Yu, Xiaoshuai
   Erasmus, Shannah Rose
   Gong, Liyan
   Liu, Jianhao
   Fan, Wei
   Liang, Yi
TI Efficacy and Safety of Acupuncture Combined with Conventional Drug
   Therapy for the Treatment of Cancer-Induced Bone Pain: A Network
   Meta-Analysis of Randomized Controlled Trials
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE cancer-induced bone pain; acupuncture; supplementary alternative
   therapy; network meta-analysis
AB Background: Cancer-induced bone pain (CIBP) involves both nociceptive and neuropathic components, causing significant suffering in cancer patients. Acupuncture has shown beneficial effects on CIBP. However, given the diverse acupuncture techniques, their therapeutic efficacy may vary. Objective: To evaluate the efficacy and safety of various acupuncture modalities integrated with conventional drug therapy for CIBP. Methods: Randomized controlled trials (RCTs) of acupuncture combined with conventional analgesics for CIBP were searched across eight Chinese and English databases and clinical trial registries up to September 2024. Two researchers independently performed literature screening, data extraction, and bias assessment. Data were analyzed using Stata 14.0 and R 4.2.3. Results: Twenty-two RCTs involving 1,738 patients were included, assessing techniques including manual acupuncture (MA), electroacupuncture (EA), moxibustion (MOX), acupoint injection (AI), acupoint catgut embedding (ACE), auricular-plaster therapy (AP), thumbtack needle (TN) and transcutaneous electrical acupoint stimulation (TEAS). The outcomes were assessed across 20 studies for the clinical effective rate, 13 for nausea and vomiting, and 11 for constipation.The results indicated that for the primary outcome of pain relief (as measured by clinical effective rate), TN demonstrated the highest probability of being the most effective acupuncture technique (SUCRA = 75.2%). In terms of mitigating opioid-induced adverse reactions, ACE was most effective for reducing nausea and vomiting (SUCRA = 87.7%), while EA+AP was optimal for alleviating constipation (SUCRA = 93.5%). MA +MOX achieved the best overall balance between efficacy and the incidence of adverse reactions. Conclusion: Acupuncture combined with conventional drug therapy significantly improves pain relief in CIBP and reduces opioidrelated side effects. However, due to methodological limitations and the modest sample sizes of available studies, further high-quality, multicenter trials with larger samples are needed to confirm these findings and inform clinical practice.
C1 [Wang, Xiaoying; Shen, Qiongying; Hu, Xinyi; Yu, Xiaoshuai; Erasmus, Shannah Rose; Liang, Yi] Zhejiang Chinese Med Univ, Clin Med Coll 3, 548 Binwen Rd Binjiang District, Hangzhou, Zhejiang, Peoples R China.
   [Gong, Liyan] Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China.
   [Liu, Jianhao; Fan, Wei] Sanya Tradit Chinese Med Hosp, Sanya, Hainan, Peoples R China.
   [Liang, Yi] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Cancer Hospital; Zhejiang
   Chinese Medical University
RP Liang, Y (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, 548 Binwen Rd Binjiang District, Hangzhou, Zhejiang, Peoples R China.
EM liangyiwww@126.com
RI , 胡撸胡撸瓢儿/AAS-3689-2020; shen, qiongying/KVB-9873-2024
FU Key Project of Health Science and Technology Program of National Health
   Commission [WKJ-ZJ-2436]; Key Foundation of Chinese Medicine Research
   Program of Zhejiang Province [2021ZZ017]; Key Research and Development
   Project of Hainan Province [ZDYF2022SHFZ129]
FX This work was supported by the Key Project of Health Science and
   Technology Program of National Health Commission and Zhejiang Province
   (Grant No. WKJ-ZJ-2436) ;the Key Foundation of Chinese Medicine Research
   Program of Zhejiang Province (2021ZZ017) and the Key Research and
   Development Project of Hainan Province (ZDYF2022SHFZ129) .
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NR 55
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2025
VL 18
BP 6807
EP 6826
DI 10.2147/JPR.S550454
PG 20
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Z7858
UT WOS:001642959800001
PM 41438386
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, W
   Zhou, Y
   Cai, YQ
   Wang, SS
   Shao, FB
   Du, JY
   Fang, JF
   Liu, JG
   Shao, XM
   Liu, BY
   Fang, JQ
   Liang, Y
AF Wang, Wen
   Zhou, You
   Cai, Yangqian
   Wang, Sisi
   Shao, Fangbing
   Du, Junying
   Fang, Junfan
   Liu, Jinggen
   Shao, Xiaomei
   Liu, Boyi
   Fang, Jianqiao
   Liang, Yi
TI Phosphoproteomic Profiling of Rat's Dorsal Root Ganglia Reveals mTOR as
   a Potential Target in Bone Cancer Pain and Electro-Acupuncture's
   Analgesia
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE proteomic profiling; protein microarray; mTOR; bone cancer pain;
   mechanism; electro-acupuncture
ID MAMMALIAN TARGET; NEUROPATHIC PAIN; CELL-GROWTH; RAPAMYCIN;
   ELECTROACUPUNCTURE; PHOSPHORYLATION; ACTIVATION; EXPRESSION; RICTOR;
   MODEL
AB Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and inflammatory pain, with the underlying mechanisms remaining largely unknown. Electro-acupuncture (EA) can partly alleviate BCP according to previous research. We aim to explore the proteins and major pathways involved in BCP and EA treatment through phosphoproteomic profiling. BCP rat model was built by tibial inoculation of MRMT-1 mammary gland carcinoma cells. Mechanical hyperalgesia determined by paw withdrawal thresholds (PWTs) and bone destruction manifested on the radiographs confirmed the success of modeling, which were attenuated by EA treatment. The differentially expressed phosphorylated proteins (DEPs) co-regulated by BCP modeling and EA treatment in rat dorsal root ganglions (DRGs) were analyzed through PEX100 Protein microarray. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that DEPs were significantly enriched in mammalian target of rapamycin (mTOR) signaling pathway. The phosphorylations of mTOR at Ser2448 and Thr2446 were increased in BCP and downregulated by EA. In addition, the phosphorylation of S6K and Akt, markers of the mTOR complex, were also increased in BCP and downregulated by EA. Inhibition of mTOR signaling alleviated the PWTs of BCP rats, while the mTOR agonist impaired the analgesic effect of EA. Thus, our study provided a landscape of protein phosphorylation changes in DRGs of EA-treated BCP rats and revealed that mTOR signaling can be potentially targeted to alleviate BCP by EA treatment.
C1 [Wang, Wen; Zhou, You; Cai, Yangqian; Wang, Sisi; Shao, Fangbing; Du, Junying; Fang, Junfan; Liu, Jinggen; Shao, Xiaomei; Liu, Boyi; Fang, Jianqiao; Liang, Yi] Zhejiang Chinese Med Univ, Dept Neurobiol & Acupuncture Res, Clin Med Coll 3, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.
   [Wang, Wen] Quzhou Municipal Hosp Tradit Chinese Med, Quzhou, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Fang, JQ; Liang, Y (corresponding author), Zhejiang Chinese Med Univ, Dept Neurobiol & Acupuncture Res, Clin Med Coll 3, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.
EM fangjianqiao7532@163.com; liangyiwww@zcmu.edu.cn
RI Zhou, You/IAP-9837-2023; Du, Junying/AEV-3719-2022
OI Fang, Jianqiao/0000-0002-5155-8544; 
FU Natural Science Foundation of Zhejiang Province [LGF21H270006]; National
   Natural Science Foundation of China [81674061]; Foundation of the
   Zhejiang Health Committee [2014KYA162]
FX This work was supported by a grant from the Natural Science Foundation
   of Zhejiang Province (Grant No. LGF21H270006), the National Natural
   Science Foundation of China (GrantNo. 81674061) and the Foundation of
   the Zhejiang Health Committee (Grant No. 2014KYA162). The technical
   support was given by the Key Laboratory of Acupuncture and Neurology of
   Zhejiang Province.
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NR 75
TC 16
Z9 20
U1 2
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 29
PY 2021
VL 12
AR 593043
DI 10.3389/fphar.2021.593043
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SB1XJ
UT WOS:000649794500001
PM 33995007
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lei, Y
   Duan, YY
   Wang, JS
   Yu, XD
   Deng, S
   Liu, RJ
   Si, HM
   Li, JM
   Zhang, B
AF Lei, Yi
   Duan, Yunyun
   Wang, Jisheng
   Yu, Xudong
   Deng, Sheng
   Liu, Ruijia
   Si, Hongmei
   Li, Jiameng
   Zhang, Bao
TI A randomized controlled trial for acupuncture combined with conventional
   therapy in the treatment of pain caused by prostate cancer Study
   protocol clinical trial (SPIRIT compliant)
SO MEDICINE
LA English
DT Article
DE acupuncture; prostate cancer; protocol; randomized controlled trial
ID ANALGESIA
AB Introduction: Prostate cancer refers to an epithelial malignant tumor that occurs in the prostate area. In recent years, with the improvement of people's living standards, the incidence of prostate cancer has gradually increased, which has greatly affected people's life and health and quality of life. Acupuncture has its unique advantages in treating cancer pain. We will evaluate the efficacy and safety of acupuncture and moxibustion in the treatment of pain caused by prostate cancer using a clinical randomized parallel control method. Methods/design: This pragmatic randomized controlled trial will recruit 120 patients who are diagnosed with prostate cancer. Simple randomization to conventional drug treatment with a 1:1 allocation ratio will be used. Based on the patient's pain location and the primary lesion, the acupuncture needle insertion position was determined according to the principle of local selection of acupoints. All participants will continue to receive conventional drug treatment. Discussion: This trial may provide evidence regarding the clinical effectiveness, safety, and cost-effectiveness of acupuncture for pain caused by prostate cancer.
C1 [Lei, Yi; Duan, Yunyun; Zhang, Bao] Shaanxi Univ Chinese Med, Affiliated Hosp 2, Xianyang 712000, Shaanxi, Peoples R China.
   [Wang, Jisheng; Yu, Xudong; Deng, Sheng; Liu, Ruijia; Si, Hongmei; Li, Jiameng] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Wang, Jisheng; Yu, Xudong; Deng, Sheng; Si, Hongmei; Li, Jiameng] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Androl, Beijing, Peoples R China.
   [Liu, Ruijia] Beijing Univ Chinese Med, Dongzhimen Hosp, Fist Dept Neurol, Beijing, Peoples R China.
C3 Shaanxi University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine
RP Zhang, B (corresponding author), Shaanxi Univ Chinese Med, Affiliated Hosp 2, Xianyang 712000, Shaanxi, Peoples R China.
EM xlht3943@sina.com
FU Current Graduate Program 2019, Dongzhimen Hospital Affiliated to Being
   University of Chinese Medicine [2019-JYB-XS-152]
FX This work will be supported by the Current Graduate Program 2019,
   Dongzhimen Hospital Affiliated to Being University of Chinese Medicine
   (No.2019-JYB-XS-152).
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NR 15
TC 5
Z9 5
U1 3
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2020
VL 99
IS 14
AR e19609
DI 10.1097/MD.0000000000019609
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LC0GC
UT WOS:000525008200029
PM 32243384
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Qiao, L
   Guo, MJ
   Qian, JJ
   Xu, B
   Gu, CY
   Yang, Y
AF Qiao, Li
   Guo, Mengjie
   Qian, Jinjun
   Xu, Bin
   Gu, Chunyan
   Yang, Ye
TI Research Advances on Acupuncture Analgesia
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Acupuncture; Moxibustion; Analgesia; Mechanism; Neurotransmitters;
   Review
ID MUSCLE BLOOD-FLOW; CANCER-RELATED FATIGUE; DORSAL RAPHE NUCLEUS; MANUAL
   ACUPUNCTURE; CHINESE MEDICINE; OPIOID RECEPTORS; NITRIC-OXIDE;
   ELECTROACUPUNCTURE; PAIN; RAT
AB Pain is a widespread and complex symptom which causes serious emotional and social burdens to individuals and society. Most patients with pain rely heavily on over the counter (OTC) and prescription pain killers. However, there would be a number of issues that arise from the use of pain killers, in which safety and addiction are the most critical issues. For traditional Chinese medicine (TCM), pain is a result of the meridians being blocked. This could occur as a symptom of or be caused by various diseases. In this case, the key to relieve pain depends on dredging the meridian or meridians. Acupuncture has been practiced in China for over 2000 years to lessen pain. It is based on the "meridian theory". Acupuncture is being used more widely and with a growing number of people in the treatment of pain because it is safer and has fewer side effects. Along with growing use and interest in acupuncture to treat pain, more attention has been paid to the mechanism underlying its analgesic effect, which is mainly associated with the changes of neurotransmitters. In this review, we summarize and analyze the range and mechanism of acupuncture analgesia treatment.
C1 [Qiao, Li; Guo, Mengjie] Nanjing Univ Chinese Med, Affiliated Hosp 3, Nanjing 210001, Peoples R China.
   [Qiao, Li; Guo, Mengjie; Qian, Jinjun; Gu, Chunyan; Yang, Ye] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
   [Xu, Bin; Yang, Ye] Nanjing Univ Chinese Med, Chinese Minist Educ, Key Lab Combinat Acupuncture & Chinese Mat Med, Nanjing 210023, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Gu, CY; Yang, Y (corresponding author), Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM guchunyan@njucm.edu.cn; yangye876@sina.com
RI YANG, YE/B-8740-2014
OI YANG, YE/0000-0003-0228-5102
FU National Natural Science Foundation of China [81770220, 81600177,
   81670200]; Innovation Team of Six Talent Peaks Project in Jiangsu
   Province [TD-SWYY-015]; 2016 outstanding youth fund of Jiangsu Province
   [BK20160048]; Natural Science Foundation of Jiangsu Province
   [BK20161041]; National key research and development program-precision
   medicine sub-program [2016YFC0905900]; Priority Academic Program
   Development of Jiangsu Higher Education Institutions for Chinese
   Medicine
FX This work was supported by National Natural Science Foundation of China
   81770220, 81600177 (to C.G.), 81670200 (to Y.Y.); Innovation Team of Six
   Talent Peaks Project in Jiangsu Province TD-SWYY-015 (to C.G.); The 2016
   outstanding youth fund of Jiangsu Province BK20160048 (to Y.Y.); Natural
   Science Foundation of Jiangsu Province BK20161041 (to C.G.); National
   key research and development program-precision medicine sub-program
   2016YFC0905900 (to Y.Y.); The Priority Academic Program Development of
   Jiangsu Higher Education Institutions for Chinese Medicine.
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NR 64
TC 71
Z9 80
U1 1
U2 61
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 2
BP 245
EP 258
DI 10.1142/S0192415X20500135
PG 14
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA LL4UY
UT WOS:000531553500001
PM 32138535
DA 2026-01-16
ER

PT J
AU de Sousa, TR
   Mattos, S
   Marcon, G
   Furtado, T
   da Silva, MD
AF de Sousa, Tatiane Regina
   Mattos, Suzana
   Marcon, Giovanna
   Furtado, Thayna
   Duarte da silva, Morgana
TI Acupuncture techniques and acupoints used in individuals under
   chemotherapy or radiotherapy treatment of cancer: A systematic review
SO JOURNAL OF CLINICAL NURSING
LA English
DT Review
DE acupoints; acupuncture; cancer; pain
ID INDUCED PERIPHERAL NEUROPATHY; BREAST-CANCER; SYMPTOM BURDEN; PAIN;
   MANAGEMENT; ELECTROACUPUNCTURE; EFFICACY; FATIGUE; TUMOR
AB Aims and ObjectivesTo describe the main acupuncture techniques and parameters that have been used in the most varied symptoms of different types of cancer. BackgroundClinical evidence about the potential effectiveness of acupuncture and related therapies to control signs and symptoms associated with cancer or its treatment has been in several studies. Currently, there is already evidence of the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry mouth, anxiety, depression, insomnia and pain. However, many studies lack firm rights or reproducible guidelines for treatment. DesignThis study performs a systematic review of clinical trials related to the topic, based on the PRISMA protocol. Thus, a search was carried out in the Scopus, Pubmed and Web of Science databases, covering studies since January 2007. MethodsStructured and organised according to PICO standards, using keywords ("cancer" OR "malignant tumour" OR "chemotherapy" OR "radiotherapy") AND ("acupuncture" OR "electroacupuncture") AND ("pain" OR "nausea" OR "vomit" OR "fatigue" OR "xerostomia" OR "insomnia" OR "depression" OR "neuropathy"). ResultsAfter the selection and evaluation phase, 23 studies were included and analysed. ConclusionBased on this analysis, it is concluded that acupuncture is safe and there is evidence of the reduction of gastrointestinal symptoms, chemotherapy-induced peripheral neuropathy, pain, dry mouth, fatigue, insomnia, and improvement of cognitive capacity. Relevance to clinical practiceAcupuncture treatments could act by minimising the side effects of conventional treatments and reducing symptoms induced by tumours. No Patient or Public ContributionThe patients had no direct involvement with the study in question.
C1 [de Sousa, Tatiane Regina; Duarte da silva, Morgana] Univ Fed Santa Catarina, Program Postgrad Neurosci, Florianopolis, Brazil.
   [de Sousa, Tatiane Regina; Duarte da silva, Morgana] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, Lab Neurobiol Pain & Inflammat LANDI, Florianopolis, Brazil.
   [Mattos, Suzana; Marcon, Giovanna; Furtado, Thayna] Estacio Santa Catarina Univ Ctr, Dept physiotherapy, Sao Jose, Brazil.
   [de Sousa, Tatiane Regina; Duarte da silva, Morgana] Univ Fed Santa Catarina, Program Postgrad Neurosci, Univ Campus, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC)
RP de Sousa, TR; da Silva, MD (corresponding author), Univ Fed Santa Catarina, Program Postgrad Neurosci, Univ Campus, BR-88040900 Florianopolis, SC, Brazil.
EM tatianereginafisio@gmail.com; morgana.silva@ufsc.br
RI da Silva, Morgana Duarte/D-4942-2015; Sousa, Tatiane Regina
   de/O-9250-2016
OI da Silva, Morgana Duarte/0000-0002-2487-236X; Sousa, Tatiane Regina
   de/0000-0002-9551-3989
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NR 41
TC 16
Z9 17
U1 5
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD OCT
PY 2023
VL 32
IS 19-20
BP 6917
EP 6933
DI 10.1111/jocn.16812
EA JUN 2023
PG 17
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA U0VB3
UT WOS:001018232200001
PM 37382085
DA 2026-01-16
ER

PT J
AU Lu, WD
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S.
TI Acupuncture for Cancer Pain and Related Symptoms
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Acupuncture; Acupuncture protocol; Aromatase inhibitor-associated joint
   pain; Cancer pain; Chemotherapy-induced neuropathy; Clinical practice;
   Clinical trials; Electroacupuncture; Evidence; Neck dissection-related
   pain; Oncology acupuncture; Opioid-induced constipation; Opioid-induced
   pruritus; Postoperative cancer pain; Postoperative nausea and vomiting;
   Postsurgical gastroparesis syndrome
ID LOW-BACK-PAIN; INTEGRATIVE ONCOLOGY; CONTROLLED-TRIAL; COMPLEMENTARY
   THERAPIES; POSTOPERATIVE NAUSEA; ELECTROACUPUNCTURE; MANAGEMENT;
   PLACEBO; OUTPATIENTS; EXPRESSION
AB Cancer pain is one of most prevalent symptoms in patients with cancer. Acupuncture and related techniques have been suggested for the management of cancer pain. The National Comprehensive Cancer Network guidelines for adult cancer pain recommends acupuncture, as one of several integrative interventions, in conjunction with pharmacologic intervention as needed. This review presents the latest available evidence regarding the use of acupuncture for cancer pain. It also provides "actionable" acupuncture protocols for specific cancer pain conditions and related symptoms in order to provide more clinically relevant solutions for clinicians and cancer patients with pain. These conditions include postoperative cancer pain, postoperative nausea and vomiting, postsurgical gastroparesis syndrome, opioid-induced constipation, opioid-induced pruritus, chemotherapy-induced neuropathy, aromatase inhibitor-associated joint pain, and neck dissection-related pain and dysfunction.
C1 [Lu, Weidong; Rosenthal, David S.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard Medical School
RP Lu, WD (corresponding author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, 44 Binney St, Boston, MA 02115 USA.
EM weidong_lu@dfci.harvard.edu
RI Lu, Weidong/C-3844-2008
OI Lu, Weidong/0000-0003-2838-6307
FU National Center for Complementary and Alternative Medicine (NCCAM) [1K01
   AT004415]
FX This study was supported by grant #1K01 AT004415 from the National
   Center for Complementary and Alternative Medicine (NCCAM).
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NR 54
TC 60
Z9 71
U1 5
U2 99
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD MAR
PY 2013
VL 17
IS 3
DI 10.1007/s11916-013-0321-3
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 099OD
UT WOS:000315630200006
PM 23338773
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Lin, JG
   Chen, YH
AF Lin, Jaung-Geng
   Chen, Yi-Hung
TI The Role of Acupuncture in Cancer Supportive Care
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Acupuncture; Cancer Care; Pain; Nausea; Vomiting; Xerostomia;
   Nervousness and Insomnia; Review
ID RADIATION-INDUCED XEROSTOMIA; CHEMOTHERAPY-INDUCED NAUSEA; AURICULAR
   ACUPUNCTURE; ELECTROACUPUNCTURE; STIMULATION; ANALGESIA; PAIN;
   DEXAMETHASONE; MOXIBUSTION; INSOMNIA
AB Acupuncture has many beneficial effects during cancer therapy and has proven efficacy in the management of side effects induced by chemotherapy and radiotherapy. In this review, we discussed the benefits of acupuncture on cancer patients. In cancer pain management, acupuncture is effective for head and neck pain, waist pain, abdominal and chest pain. Many studies confirm the excellent efficacy of acupuncture against symptoms of vomiting and nausea, including those induced by chemotherapy and radiotherapy. Head and neck cancer patients receiving radiotherapy may develop xerostomia, which may be relieved by acupuncture. Acupuncture may also cause sedative and hypnotic effects in cancer patients for treating nervousness and insomnia.
C1 [Lin, Jaung-Geng] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan.
   [Chen, Yi-Hung] China Med Univ, Grad Inst Acupuncture Sci, Taichung 404, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan
RP Lin, JG (corresponding author), China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM jglin@mail.cmu.edu.tw; yihungchen@mail.cmu.edu.tw
RI Chen, Yi-Hung/L-8189-2013
FU Committee on Chinese Medicine and Pharmacy, Department of Health,
   Taipei, Taiwan [CCMP 100-RD-31]; National Science Council, Taipei,
   Taiwan [NSC-100-2320-B-039-029-MY2]
FX This work was supported by grant CCMP 100-RD-31 from the Committee on
   Chinese Medicine and Pharmacy, Department of Health, Taipei, Taiwan and
   grant NSC-100-2320-B-039-029-MY2 from the National Science Council,
   Taipei, Taiwan.
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NR 53
TC 31
Z9 35
U1 1
U2 39
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2012
VL 40
IS 2
BP 219
EP 229
DI 10.1142/S0192415X12500176
PG 11
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA 908QH
UT WOS:000301504700001
PM 22419418
DA 2026-01-16
ER

PT J
AU Han, QQ
   Fu, Y
   Le, JM
   Ma, YJ
   Wei, XD
   Ji, HL
   Jiang, HC
   Gao, YQ
   Wu, HL
AF Han, Qiu-Qin
   Fu, Yi
   Le, Jia-Mei
   Ma, Yu-Jie
   Wei, Xin-Dong
   Ji, Hou-Lin
   Jiang, Haochen
   Gao, Yueqiu
   Wu, Hailong
TI The Therapeutic Effects of Acupuncture and Electro-acupuncture on
   Cancer-related Symptoms and Side-Effects
SO JOURNAL OF CANCER
LA English
DT Review
DE acupuncture; electroacupuncture; cancer; surgery; chemotherapy; pain
ID CHEMOTHERAPY-INDUCED NAUSEA; QUALITY-OF-LIFE; INHIBITOR-RELATED
   ARTHRALGIA; BREAST-CANCER; PSYCHOLOGICAL DISTRESS; PEDIATRIC ONCOLOGY;
   DOUBLE-BLIND; FATIGUE; PAIN; PREVALENCE
AB In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention. In this review, we summarized the clinical application of acupuncture and EA in alleviating the cancer symptoms, reducing the cancer treatment-related side-effects, and relieving the cancer pain. The symptoms and side-effects discussed in this review include fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), pain, xerostomia, and anxiety and depression. The underlying mechanisms of the therapeutic effects of acupuncture and EA might be related to the regulation of the mitochondrial function, coordination of the activity of the nervous system, adjustment of the production of neurotransmitters, and alleviation of the immune responses. In conclusion, acupuncture and EA have been proved to be beneficial for cancer patients. More research, however, is required to clarify the potential mechanisms behind acupuncture and EA for widespread adoption in clinical application.
C1 [Han, Qiu-Qin; Fu, Yi; Le, Jia-Mei; Ma, Yu-Jie; Wei, Xin-Dong; Ji, Hou-Lin; Wu, Hailong] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai 201318, Peoples R China.
   [Han, Qiu-Qin; Fu, Yi; Le, Jia-Mei; Ma, Yu-Jie; Wei, Xin-Dong; Ji, Hou-Lin; Wu, Hailong] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China.
   [Han, Qiu-Qin; Fu, Yi; Le, Jia-Mei; Ma, Yu-Jie; Wei, Xin-Dong; Ji, Hou-Lin; Wu, Hailong] Shanghai Univ Med & Hlth Sci, Collaborat Innovat Ctr Biomed, Shanghai 201318, Peoples R China.
   [Jiang, Haochen; Gao, Yueqiu] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Cent Lab, Inst Clin Immunol,Dept Liver Dis, Shanghai 200021, Peoples R China.
   [Jiang, Haochen; Gao, Yueqiu] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Lab Cellular Immun, Shanghai 200021, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences; Shanghai University
   of Medicine & Health Sciences; Shanghai University of Medicine & Health
   Sciences; Shanghai University of Traditional Chinese Medicine; Shanghai
   University of Traditional Chinese Medicine
RP Wu, HL (corresponding author), Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai 201318, Peoples R China.; Wu, HL (corresponding author), Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China.; Wu, HL (corresponding author), Shanghai Univ Med & Hlth Sci, Collaborat Innovat Ctr Biomed, Shanghai 201318, Peoples R China.; Gao, YQ (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Cent Lab, Inst Clin Immunol,Dept Liver Dis, Shanghai 200021, Peoples R China.; Gao, YQ (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Lab Cellular Immun, Shanghai 200021, Peoples R China.
EM gaoyueqiu@hotmail.com; wuhl@sumhs.edu.cn
RI ma, yujie/GYA-3957-2022; xindong, wei/LRS-8151-2024; Fu,
   Yi/HGB-5480-2022
OI Fu, Yi/0000-0001-6911-0724; Le, Jiamei/0000-0002-4776-1347; Wu,
   Hailong/0000-0003-2843-7610
FU National Natural Science Foundation of China [81830052, 31870905,
   81673938, 81874436, 81903961]; Scientific Program of Shanghai Municipal
   Health Commission [SHWJ2019211]; Shanghai Municipal Education Commission
   [ZZJKYX19006]; Natural Science Foundation of Shanghai [19ZR1424000];
   Construction Project of Shanghai Key Laboratory of Molecular Imaging
   [18DZ2260400]; Shanghai Municipal Education Commission (Class II Plateau
   Disciplinary Construction Program of Medical Technology of SUMHS,
   2018-2020); School-level Fund [E3-0200-21-201011-73]; Hundred Teacher
   Talent Program of Shanghai University of Medicine and Health Sciences
FX This review was by grants from the National Natural Science Foundation
   of China (31870905 to H Wu, 81673938 and 81874436 to Y Gao, 81903961 to
   J Le), the Scientific Program of Shanghai Municipal Health Commission
   (SHWJ2019211 to H Wu), the Shanghai Municipal Education Commission
   (ZZJKYX19006 to Q-Q Han), the Natural Science Foundation of Shanghai
   (19ZR1424000 to J Le), the National Natural Science Foundation of China
   (No. 81830052), Construction Project of Shanghai Key Laboratory of
   Molecular Imaging (18DZ2260400), Shanghai Municipal Education Commission
   (Class II Plateau Disciplinary Construction Program of Medical
   Technology of SUMHS, 2018-2020), the School-level Fund
   (E3-0200-21-201011-73) and the Hundred Teacher Talent Program of
   Shanghai University of Medicine and Health Sciences.
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NR 78
TC 37
Z9 42
U1 4
U2 47
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2021
VL 12
IS 23
BP 7003
EP 7009
DI 10.7150/jca.55803
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WO2XI
UT WOS:000712322300008
PM 34729102
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Paley, CA
   Johnson, MI
   Tashani, OA
   Bagnall, AM
AF Paley, Carole A.
   Johnson, Mark I.
   Tashani, Osama A.
   Bagnall, Anne-Marie
TI Acupuncture for cancer pain in adults
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Pain Management; Acupuncture Therapy [*methods]; Acupuncture, Ear
   [methods]; Neoplasms [*complications]; Pain [etiology]; Pain
   Measurement; Randomized Controlled Trials as Topic; Adult; Humans
ID PALLIATIVE CARE; AURICULAR ACUPUNCTURE; BONE PAIN; MANAGEMENT;
   ELECTROACUPUNCTURE; OSTEOARTHRITIS; CHEMOTHERAPY; METAANALYSIS; SHAM
AB Background
   Forty per cent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief. It has been claimed that acupuncture has a role in management of cancer pain and guidelines exist for treatment of cancer pain with acupuncture. This is an updated version of a Cochrane Review published in Issue 1, 2011, on acupuncture for cancer pain in adults.
   Objectives
   To evaluate efficacy of acupuncture for relief of cancer-related pain in adults.
   Search methods
   For this update CENTRAL, MEDLINE, EMBASE, PsycINFO, AMED, and SPORTDiscus were searched up to July 2015 including non-English language papers.
   Selection criteria
   Randomised controlled trials (RCTs) that evaluated any type of invasive acupuncture for pain directly related to cancer in adults aged 18 years or over.
   Data collection and analysis
   We planned to pool data to provide an overall measure of effect and to calculate the number needed to treat to benefit, but this was not possible due to heterogeneity. Two review authors (CP, OT) independently extracted data adding it to data extraction sheets. Data sheets were compared and discussed with a third review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT and MJ.
   Main results
   We included five RCTs (285 participants). Three studies were included in the original review and two more in the update. The authors of the included studies reported benefits of acupuncture in managing pancreatic cancer pain; no difference between real and sham electroacupuncture for pain associated with ovarian cancer; benefits of acupuncture over conventional medication for late stage unspecified cancer; benefits for auricular (ear) acupuncture over placebo for chronic neuropathic pain related to cancer; and no differences between conventional analgesia and acupuncture within the first 10 days of treatment for stomach carcinoma. All studies had a high risk of bias from inadequate sample size and a low risk of bias associated with random sequence generation. Only three studies had low risk of bias associated with incomplete outcome data, while two studies had low risk of bias associated with allocation concealment and one study had low risk of bias associated with inadequate blinding. The heterogeneity of methodologies, cancer populations and techniques used in the included studies precluded pooling of data and therefore meta-analysis was not carried out. A subgroup analysis on acupuncture for cancer-induced bone pain was not conducted because none of the studies made any reference to bone pain. Studies either reported that there were no adverse events as a result of treatment, or did not report adverse events at all.
   Authors' conclusions
   There is insufficient evidence to judge whether acupuncture is effective in treating cancer pain in adults.
C1 [Paley, Carole A.] Airedale NHS Fdn Trust, Res & Dev Dept, Keighley, England.
   [Johnson, Mark I.; Tashani, Osama A.; Bagnall, Anne-Marie] Leeds Beckett Univ, Fac Hlth & Social Sci, Leeds, W Yorkshire, England.
C3 Leeds Beckett University
RP Paley, CA (corresponding author), Airedale Dist Gen Hosp, Airedale NHS Fdn Trust, Dept Res & Dev, Keighley BD20 6TD, W Yorkshire, England.
EM carolepaley2@btinternet.com
RI Paley, Carole Anne/AAM-2469-2020
OI Paley, Carole Anne/0000-0002-6335-2666; Bagnall,
   Anne-Marie/0000-0003-1512-0833; Tashani, Osama/0000-0002-1998-4981
FU National Institute for Health Research (NIHR)
FX The National Institute for Health Research (NIHR) is the largest single
   funder of the Cochrane PaPaS Group. Disclaimer: The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the NIHR, National Health Service (NHS) or the
   Department of Health.
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NR 79
TC 99
Z9 116
U1 4
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2015
IS 10
AR CD007753
DI 10.1002/14651858.CD007753.pub3
PG 33
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA V47DX
UT WOS:000209933600011
PM 26468973
OA Green Submitted, Green Published, Bronze
DA 2026-01-16
ER

PT J
AU Zhao, YX
   Yao, MJ
   Shen, JW
   Zhang, WX
   Zhou, YX
AF Zhao, Yu-Xue
   Yao, Ming-Jiang
   Shen, Jian-Wu
   Zhang, Wen-Xi
   Zhou, Yuan-Xi
TI Electroacupuncture attenuates nociceptive behaviors in a mouse model of
   cancer pain
SO MOLECULAR PAIN
LA English
DT Article
DE Cancer pain; electroacupuncture; neuropeptide; inflammatory signals
ID NERVE GROWTH-FACTOR; NF-KAPPA-B; AMERICAN SOCIETY; NEUROPATHIC PAIN;
   SKELETAL PAIN; ACUPUNCTURE; CGRP; MECHANISMS; EXPRESSION; SURVIVORS
AB Pain is a major symptom in cancer patients, and cancer-induced bone pain (CIBP) is the most common type of moderate and severe cancer-related pain. The current available analgesic treatments for CIBP have adverse effects as well as limited therapeutic effects. Acupuncture is proved effective in pain management as a safe alternative therapy. We evaluated the analgesic effect of acupuncture in treatment of cancer pain and try to explore the underlying analgesic mechanisms. Nude mice were inoculated with cancer cells into the left distal femur to establish cancer pain model. Electroacupuncture (EA) treatment was applied for the xenograft animals. Pain behaviors of mice were evaluated, followed by the detections of neuropeptide-related and inflammation-related indicators in peripheral and central levels. EA treatment alleviated cancer-induced pain behaviors covering mechanical allodynia, thermal hyperalgesia and spontaneous pain, and also down-regulated immunofluorescence expressions of neuropeptide CGRP and p75 in the skin of affected plantar area in xenograft mice, and inhibited expressions of overexpressed neuropeptide-related and inflammation-related protein in the lumbar spinal cord of xenograft mice. Overall, our findings suggest that EA treatment ameliorated cancer-induced pain behaviors in the mouse xenograft model of cancer pain, possibly through inhibiting the expressions of neuropeptide-related and inflammation-related protein in central level following tumor cell xenografts.
C1 [Zhao, Yu-Xue; Yao, Ming-Jiang; Shen, Jian-Wu; Zhang, Wen-Xi; Zhou, Yuan-Xi] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Dongzhimen St, Beijing 100700, Peoples R China.
   [Yao, Ming-Jiang] China Acad Chinese Med Sci, Inst Basic Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Yao, Ming-Jiang] Key Lab Pharmacol Chinese Mat Med, Beijing, Peoples R China.
   [Shen, Jian-Wu] China Acad Chinese Med Sci, Inst Geriatr Med, Xiyuan Hosp, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Acupuncture &
   Moxibustion, CACMS; China Academy of Chinese Medical Sciences; Xiyuan
   Hospital, CACMS; China Academy of Chinese Medical Sciences; Xiyuan
   Hospital, CACMS
RP Zhao, YX (corresponding author), China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Dongzhimen St, Beijing 100700, Peoples R China.
EM claricezhao@live.cn
FU Chinese Government Scholarship
FX We express our appreciation to all our lab. members for fostering a
   positive and supportive environment that consistently encourages us to
   explore the potential of our ideas and learn from our setbacks.
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NR 58
TC 5
Z9 5
U1 4
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD MAR
PY 2024
VL 20
AR 17448069241240692
DI 10.1177/17448069241240692
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA NO4Z3
UT WOS:001201391400001
PM 38443317
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tang, QL
   Zhang, K
AF Tang, Qilin
   Zhang, Kai
TI Association of Acupuncture and Acupressure With Improved Cancer Pain
SO JAMA ONCOLOGY
LA English
DT Letter
ID BREAST-CANCER
C1 [Tang, Qilin] Hebei Univ Chinese Med, Sch Basic Med Sci, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China.
   [Zhang, Kai] Tianjin Gong An Hosp, Dept Acupuncture & Moxibust, 78 Nanjing Rd, Tianjin 300042, Peoples R China.
C3 Hebei University of Chinese Medicine
RP Tang, QL (corresponding author), Hebei Univ Chinese Med, Sch Basic Med Sci, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China.; Zhang, K (corresponding author), Tianjin Gong An Hosp, Dept Acupuncture & Moxibust, 78 Nanjing Rd, Tianjin 300042, Peoples R China.
EM tqilin123@126.com; coolzhangkai@163.com
RI Zhang, Kai/B-1769-2019
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NR 5
TC 3
Z9 4
U1 0
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD JUN
PY 2020
VL 6
IS 6
BP 938
EP 938
DI 10.1001/jamaoncol.2020.0616
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MA6QT
UT WOS:000542037700033
PM 32324212
DA 2026-01-16
ER

PT J
AU Meng, FF
   Feng, YH
AF Meng, Fan-feng
   Feng, Yan-hong
TI A pilot study of acupuncture at pain acupoints for cervical cancer pain
SO MEDICINE
LA English
DT Article
DE acupuncture; adverse event; cancer pain; cervical cancer; effectiveness
ID QUALITY-OF-LIFE; MANAGEMENT; OPIOIDS
AB This retrospective study aimed to investigate the feasible effectiveness of acupuncture at pain acupoints for the treatment of patients with cervical cancer pain (CCP). A total of 64 cases were analyzed. All these cases were assigned to an acupuncture group or a control group according to the different therapies they received. The cases in the acupuncture group received acupuncture treatment at pain acupoints, while the subjects in the control group underwent acupuncture at regular acupoints. The primary endpoint was CCP, assessed by numeric rating scale (NRS). The secondary endpoints were evaluated by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30), and Karnofsky Performance Status (KPS). In addition, adverse events were also recorded during the treatment period. After treatment, patients in the acupuncture group exerted greater outcomes in CCP reduction when compared with patients in the control group (P<.01). In addition, no adverse events were recorded in either group. The results of this study showed that acupuncture at pain acupoints might be efficacious in patients with CCP after 14-day treatment.
C1 [Meng, Fan-feng; Feng, Yan-hong] Shaanxi Univ Chinese Med, Affiliated Hosp 2, Dept Gynecol & Obstet, 5 Weiyang West Rd, Xianyang 712000, Peoples R China.
C3 Shaanxi University of Chinese Medicine
RP Feng, YH (corresponding author), Shaanxi Univ Chinese Med, Affiliated Hosp 2, Dept Gynecol & Obstet, 5 Weiyang West Rd, Xianyang 712000, Peoples R China.
EM 50448538@qq.com
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NR 30
TC 9
Z9 10
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2018
VL 97
IS 52
AR e13736
DI 10.1097/MD.0000000000013736
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HI3HD
UT WOS:000456338700024
PM 30593148
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, BL
   Lu, Z
   Huang, Y
AF Wang, Bolin
   Lu, Zhong
   Huang, Yan
TI Association of Acupuncture and Acupressure With Improved Cancer Pain
SO JAMA ONCOLOGY
LA English
DT Letter
C1 [Wang, Bolin] Weifang Med Univ, Weifang, Peoples R China.
   [Lu, Zhong; Huang, Yan] Weifang Med Univ, Affiliated Hosp, Dept Oncol, Weifang 261031, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University
RP Huang, Y (corresponding author), Weifang Med Univ, Affiliated Hosp, Dept Oncol, Weifang 261031, Peoples R China.
EM yanhuangdr@163.com
CR He YH, 2020, JAMA ONCOL, V6, P271, DOI 10.1001/jamaoncol.2019.5233
NR 1
TC 1
Z9 1
U1 0
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD JUN
PY 2020
VL 6
IS 6
BP 938
EP +
DI 10.1001/jamaoncol.2020.0619
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MA6QT
UT WOS:000542037700034
PM 32324200
DA 2026-01-16
ER

PT J
AU An, LX
   Chen, X
   Ren, XJ
   Wu, HF
AF An, Li-Xin
   Chen, Xue
   Ren, Xiu-Jun
   Wu, Hai-Feng
TI Electro-Acupuncture Decreases Postoperative Pain and Improves Recovery
   in Patients Undergoing a Supratentorial Craniotomy
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Electro-Acupuncture; Supratentorial Craniotomy; Postoperative Pain;
   Appetite; Dizziness
ID ACUPUNCTURE ANALGESIA; STIMULATION
AB We performed this study to examine the effect of electro-acupuncture (EA) on postoperative pain, postoperative nausea and vomiting (PONV) and recovery in patients after a supratentorial tumor resection. Eighty-eight patients requiring a supratentorial tumor resection were anesthetized with sevoflurane and randomly allocated to a no treatment group (Group C) or an EA group (Group A). After anesthesia induction, the patients in Group A received EA at LI4 and SJ5, at BL63 and LR3 and at ST36 and GB40 on the same side as the craniotomy. The stimulation was continued until the end of the operation. Patient-controlled intravenous analgesia (PCIA) was used for the postoperative analgesia. The postoperative pain scores, PONV, the degree of dizziness and appetite were recorded. In the first 6 hours after the operation, the mean total bolus, the effective times of PCIA bolus administrations and the VAS scores were much lower in the EA group (p < 0: 05). In the EA group, the incidence of PONV and degree of dizziness and feeling of fullness in the head within the first 24 hours after the operation was much lower than in the control group (p < 0: 05). In the EA group, more patients had a better appetite than did the patients in group C (51.2% vs. 27.5%) (p < 0: 05). The use of EA in neurosurgery patients improves the quality of postoperative analgesia, promotes appetite recovery and decreases some uncomfortable sensations, such as dizziness and feeling of fullness in the head.
C1 [An, Li-Xin] Capital Med Univ, Beijing Tiantan Hosp, Dept Anesthesia, Beijing 100050, Peoples R China.
   [Chen, Xue] Beijing Jishuitan Hosp, Dept Anesthesia, Beijing 100035, Peoples R China.
   [Ren, Xiu-Jun] Beijing Univ Tradit Chinese Med, Dept Acupuncture, Beijing 100029, Peoples R China.
   [Wu, Hai-Feng] Capital Med Univ, Dept Epidemiol & Biostat, Beijing 100069, Peoples R China.
C3 Capital Medical University; Beijing University of Chinese Medicine;
   Capital Medical University
RP An, LX (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, Dept Anesthesia, 6 Tiantan Xili, Beijing 100050, Peoples R China.
EM anlixin8120@163.com
FU National Basic Research Program of China (973 Program) [2007CB512503]
FX Financial support for this study was provided by the National Basic
   Research Program of China (973 Program), No. 2007CB512503.
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NR 24
TC 58
Z9 65
U1 0
U2 27
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2014
VL 42
IS 5
BP 1099
EP 1109
DI 10.1142/S0192415X14500682
PG 11
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA AQ1TA
UT WOS:000342562800004
PM 25169910
DA 2026-01-16
ER

PT J
AU Ge, L
   Wang, Q
   He, YH
   Wu, DR
   Zhou, Q
   Xu, NG
   Yang, KH
   Chen, YL
   Zhang, AL
   Hua, HQ
   Huang, JC
   Hui, KK
   Liang, FR
   Wang, LP
   Xu, B
   Yang, YF
   Zhang, WM
   Zhao, BX
   Zhu, B
   Guo, XF
   Xue, CC
   Zhang, HB
   Xue, CC
   Xue, CC
   Zhang, HB
   Guo, XF
   Wu, DR
   Yang, KH
   Chen, YL
   Ge, L
   He, RN
   Hua, HQ
   Huang, JC
   Hui, KK
   Liang, FR
   Pan, ZD
   Wang, LP
   Xu, B
   Xu, NG
   Yang, YF
   Zhang, AL
   Zhang, WM
   Zhao, BX
   Zhu, B
   Wang, Q
   He, YH
   Zhou, Q
   Yang, LH
   Liu, SN
   Li, JY
   Hou, LY
   Zhang, Q
   Lai, HH
   Chen, XL
   Deng, XY
   Kang, FQ
AF Ge, Long
   Wang, Qi
   He, Yihan
   Wu, Darong
   Zhou, Qi
   Xu, Nenggui
   Yang, Kehu
   Chen, Yaolong
   Zhang, Anthony Lin
   Hua, Haiqing
   Huang, Jinchang
   Hui, Ka-Kit
   Liang, Fanrong
   Wang, Linpeng
   Xu, Bin
   Yang, Yufei
   Zhang, Weimin
   Zhao, Baixiao
   Zhu, Bing
   Guo, Xinfeng
   Xue, Charlie Changli
   Zhang, Haibo
   Xue, Charlie Changli
   Xue, Charlie Changli
   Zhang, Haibo
   Guo, Xinfeng
   Wu, Darong
   Yang, Kehu
   Chen, Yaolong
   Ge, Long
   He, Runsen
   Hua, Haiqing
   Huang, Jinchang
   Hui, Ka-Kit
   Liang, Fanrong
   Pan, Zuodi
   Wang, Linpeng
   Xu, Bin
   Xu, Nenggui
   Yang, Yufei
   Zhang, Anthony Lin
   Zhang, Weimin
   Zhao, Baixiao
   Zhu, Bing
   Wang, Qi
   He, Yihan
   Zhou, Qi
   Yang, Lihong
   Liu, Shaonan
   Li, Jieyun
   Hou, Liangying
   Zhang, Qian
   Lai, Honghao
   Chen, Xueling
   Deng, Xueyi
   Kang, Fuqin
TI Acupuncture for cancer pain: an evidence-based clinical practice
   guideline
SO CHINESE MEDICINE
LA English
DT Review
DE Acupuncture; Cancer pain; Practice guideline; Evidence-based practice
ID BREAST-CANCER; INTEGRATIVE ONCOLOGY; HEALTH-CARE; MANAGEMENT;
   ELECTROACUPUNCTURE; COMPLEMENTARY; TRIAL; WOMEN
AB Background: This study aims to develop an evidence-based clinical practice guideline of acupuncture in the treatment of patients with moderate and severe cancer pain.
   Methods: The development of this guideline was triggered by a systematic review published in JAMA Oncology in 2020. We searched databases and websites for evidence on patient preferences and values, and other resources of using acupuncture for treatment of cancer pain. Recommendations were developed through a Delphi consensus of an international multidisciplinary panel including 13 western medicine oncologists, Chinese medicine/acupuncture clinical practitioners, and two patient representatives. The certainty of evidence, patient preferences and values, resources, and other factors were fully considered in formulating the recommendations. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was employed to rate the certainty of evidence and the strength of recommendations.
   Results: The guideline proposed three recommendations: (1) a strong recommendation for the treatment of acupuncture rather than no treatment to relieve pain in patients with moderate to severe cancer pain; (2) a weak recommendation for the combination treatments with acupuncture/acupressure to reduce pain intensity, decrease the opioid dose, and alleviate opioid-related side effects in moderate to severe cancer pain patients who are using analgesics; and (3) a strong recommendation for acupuncture in breast cancer patients to relieve their aromatase inhibitor-induced arthralgia.
   Conclusion: This proposed guideline provides recommendations for the management of patients with cancer pain. The small sample sizes of evidence limit the strength of the recommendations and highlights the need for additional research.
C1 [Ge, Long; Wang, Qi] Lanzhou Univ, Sch Publ Hlth, Dept Social Med & Hlth Management, Lanzhou, Peoples R China.
   [Ge, Long; Wang, Qi; Yang, Kehu] Lanzhou Univ, Sch Publ Hlth, Evidence Based Social Sci Res Ctr, Lanzhou, Peoples R China.
   [Ge, Long; Yang, Kehu; Chen, Yaolong] WHO, Collaborating Ctr Guideline Implementat & Knowled, Lanzhou, Peoples R China.
   [Yang, Kehu] Lanzhou Univ, Chinese GRADE Ctr, Lanzhou, Peoples R China.
   [He, Yihan; Wu, Darong; Xue, Charlie Changli; Zhang, Haibo; Guo, Xinfeng] Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
   [He, Yihan; Wu, Darong; Guo, Xinfeng; Xue, Charlie Changli; Zhang, Haibo] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [He, Yihan; Wu, Darong; Guo, Xinfeng; Xue, Charlie Changli; Zhang, Haibo] Guangdong Prov Acad Chinese Med Sci, Guangzhou, Peoples R China.
   [Zhou, Qi; Chen, Yaolong] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China.
   [Xu, Nenggui] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.
   [Yang, Kehu; Chen, Yaolong] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China.
   [Zhang, Anthony Lin; Xue, Charlie Changli] RMIT Univ, Sch Hlth & Biomed Sci, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.
   [Hua, Haiqing] Nanjing Univ Chinese Med, Bayi Hosp, Dept Oncol, Nanjing, Peoples R China.
   [Huang, Jinchang] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing, Peoples R China.
   [Hui, Ka-Kit] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Ctr East West Med, Los Angeles, CA USA.
   [Liang, Fanrong] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Wang, Linpeng] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.
   [Xu, Bin] Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing, Peoples R China.
   [Yang, Yufei] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Oncol, Beijing, Peoples R China.
   [Zhang, Weimin] Southern Theater Command Gen Hosp PLA, Dept Oncol, Guangzhou, Peoples R China.
   [Zhao, Baixiao] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China.
   [Zhu, Bing] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing, Peoples R China.
C3 Lanzhou University; Lanzhou University; World Health Organization;
   Lanzhou University; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese
   Medicine; Lanzhou University; Guangzhou University of Chinese Medicine;
   Royal Melbourne Institute of Technology (RMIT); Nanjing University of
   Chinese Medicine; Beijing University of Chinese Medicine; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; Chengdu University of Traditional Chinese Medicine; Capital
   Medical University; Nanjing University of Chinese Medicine; Xiyuan
   Hospital, CACMS; China Academy of Chinese Medical Sciences; Beijing
   University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Institute of Acupuncture & Moxibustion, CACMS
RP Guo, XF; Xue, CC; Zhang, HB (corresponding author), Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.; Xue, CC (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.
EM guoxinfeng@gzucm.edu; charlie.xue@rmit.edu.au; haibozh@gzucm.edu.cn
RI Liang, Fan/HGA-0248-2022; Yang, yufei/KHW-2735-2024; Ge,
   Long/G-8876-2017; Liu, Shaonan/K-4946-2019; HUA, HAIQING/MBV-5587-2025;
   Zhang, weimin/AAT-2269-2020; Zhang, Haibo/HLP-9266-2023; Yang,
   Yufei/JXX-6325-2024; zhou, qi/JEF-7253-2023; Guo, Xinfeng/AAM-6850-2021;
   Xue, Charlie C/HSE-5095-2023; Zhou, Qi/CAI-0020-2022
OI Yang, Hehu/0000-0001-7864-3012; Guo, Xinfeng/0000-0003-2699-9740; Xue,
   Charlie C/0000-0001-6937-9088; Zhou, Qi/0000-0001-7884-7074
FU National Key R&D Program, China National Centre for Biotechnology
   Development [2019YFC1709805]
FX This guideline was funded by the National Key R&D Program, China
   National Centre for Biotechnology Development (No. 2019YFC1709805). The
   funding is mainly used to pay for travel expenses and expert
   consultation expenses in the process of preparing the guideline.
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NR 74
TC 46
Z9 57
U1 7
U2 76
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD JAN 5
PY 2022
VL 17
IS 1
AR 8
DI 10.1186/s13020-021-00558-4
PG 12
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA YB0AG
UT WOS:000738685000003
PM 34983587
OA Green Submitted, Green Published, gold
DA 2026-01-16
ER

PT J
AU Cai, DB
   Yuan, WQ
   Zheng, W
AF Cai, Dong-Bin
   Yuan, Wei-Qu
   Zheng, Wei
TI Association of Acupuncture and Acupressure With Improved Cancer Pain
SO JAMA ONCOLOGY
LA English
DT Letter
C1 [Cai, Dong-Bin; Yuan, Wei-Qu] Guangzhou Univ Chinese Med, Clin Med Coll 4, Shenzhen Tradit Chinese Med Hosp, Shenzhen, Peoples R China.
   [Zheng, Wei] Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, 36 Mingxin Rd, Guangzhou 510000, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Shenzhen Traditional Chinese
   Medicine Hospital; Guangzhou Medical University
RP Zheng, W (corresponding author), Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, 36 Mingxin Rd, Guangzhou 510000, Peoples R China.
EM zhengwei0702@163.com
RI Zheng, Wei/O-3351-2013
CR Cohen J, 1988, STAT POWER ANAL BEHA, DOI DOI 10.4324/9780203771587
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   Warren JB, 2017, BRIT J CLIN PHARMACO, V83, P221, DOI 10.1111/bcp.13166
NR 5
TC 1
Z9 1
U1 0
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD JUN
PY 2020
VL 6
IS 6
BP 939
EP 940
DI 10.1001/jamaoncol.2020.0622
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MA6QT
UT WOS:000542037700035
PM 32324193
DA 2026-01-16
ER

PT J
AU Xu, LL
   Wan, YX
   Huang, J
   Xu, FY
AF Xu, Lili
   Wan, Yongxian
   Huang, Juan
   Xu, Fangyuan
TI Clinical analysis of electroacupuncture and multiple acupoint
   stimulation in relieving cancer pain in patients with advanced
   hepatocellular carcinoma
SO JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
LA English
DT Article
DE Cancerous pain; electroacupuncture; hepatocellular carcinoma; multiple
   acupoint stimulation; pain relief
ID ACUPUNCTURE; MANAGEMENT
AB Objective: The objective of this study is to investigate the clinical efficacy and safety of electroacupuncture and multiple acupoint stimulation in relieving cancer pain in patients with advanced hepatocellular carcinoma.
   Methods: Sixty-five cases of advanced hepatocellular carcinoma with cancer pain were selected in our hospital and were divided into electroacupuncture multiple acupoint stimulation group (electroacupuncture group) (n = 32) and fentanyl transdermal patch analgesia group (control group) (n = 33) according to analgesic methods and intentions. In the electroacupuncture group, electric acupuncture treatment was administered at different acupoints, including Baihui, Quchi, Neiguan, Xuehai, Zusanli, and Sanyinjiao acupoint, once a day for 7 days. In the control group, a fentanyl transdermal patch was placed on the upper left arm every 3 days and replaced with a continuous external paste once for 7 days. Pain scores in the two groups before and during the treatment were evaluated with a visual analog scale (VAS), and adverse reactions during the treatment were recorded.
   Results: The VAS pain score of the electroacupuncture group was significantly decreased on day 3 (P < 0.05), but the pain scores were not significantly different (P > 0.05) between the two groups 4 days after treatment. For treatment-related side effects, there were 3 cases of subcutaneous hemorrhage in the electroacupuncture group; 1 case of skin rashes and 3 cases of nausea and vomiting in the control group. The incidences of adverse reactions in the two groups were 9.4% and 12.1%, respectively, without significant difference (P > 0.05).
   Conclusion: Cancer pain in patients with advanced hepatocellular carcinoma can be alleviated with electroacupuncture and multiple acupoint stimulation, but the onset pain relief was slow. To improve the analgesic effects of this technique, the combination of various analgesic methods should be necessary in early stage of the treatment.
C1 [Xu, Lili; Huang, Juan; Xu, Fangyuan] Southwest Med Univ, Affiliated Hosp, Dept Rehabil, Luzhou 646000, Peoples R China.
   [Wan, Yongxian] Southwest Med Univ, Affiliated Hosp, Dept Bone & Joint Surg, Luzhou, Peoples R China.
C3 Southwest Medical University; Southwest Medical University
RP Xu, LL (corresponding author), Southwest Med Univ, Affiliated Hosp, Dept Rehabil, Luzhou 646000, Peoples R China.
EM 171714336@qq.com
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PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0973-1482
EI 1998-4138
J9 J CANCER RES THER
JI J. Canc. Res. Ther.
PD JAN
PY 2018
VL 14
IS 1
BP 99
EP 102
DI 10.4103/jcrt.JCRT_736_17
PG 4
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FZ1WL
UT WOS:000427368100019
PM 29516968
OA gold
DA 2026-01-16
ER

PT J
AU Shah, S
   Godhardt, L
   Spofford, C
AF Shah, Shivani
   Godhardt, Lisa
   Spofford, Christina
TI Acupuncture and Postoperative Pain Reduction
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Perioperative pain; Perioperative analgesia; Perioperative acupuncture;
   Electroacupuncture; Transcutaneous electric acupoint stimulation;
   Moxibustion; Acupressure
ID GASTRIC-CANCER; ELECTROACUPUNCTURE; STIMULATION; ACUPRESSURE; ANALGESIA;
   SURGERY
AB Purpose of Review Acupuncture is an analgesic technique that has long been utilized in Eastern medicine. In recent times, various acupuncture techniques have been used in integrated pain management approaches in Western medicine. It has even been adopted as an analgesic method in surgical patients. Currently, no review exists regarding various acupuncture techniques used in perioperative pain management and data describing the utility of these techniques. This paper synthesizes the latest literature regarding the role of acupuncture in perioperative pain management. The authors sought to describe various acupuncture modalities used to help manage surgical pain and synthesize the current body of literature to help readers make informed judgements on the topic. Recent Findings Patients undergoing abdominal, spine/neuro, and gynecologic pelvic surgery generally benefit from acupuncture. Out of the various acupuncture techniques, electroacupuncture, transcutaneous electric acupoint stimulation, and traditional total body acupuncture seem to be most promising as adjuncts to multimodal perioperative analgesia. Benefits include improved analgesia and/or reduced narcotic requirements, decrease in PONV, and shorter time to return of bowel function. Acupuncture is a low-risk method that has the potential to enhance perioperative analgesia, decrease opioid requirement, and reduce unwanted side effects of anesthesia, surgery, and opioid administration such as nausea/vomiting. Given the variety of patient populations, various acupuncture techniques, and small patient populations for most current studies; it remains difficult to determine which acupuncture method would most benefit specific patients. Future studies with more robust sample sizes and prospective comparison on acupuncture technique would help better characterize acupuncture's role in perioperative pain management.
C1 [Shah, Shivani; Godhardt, Lisa; Spofford, Christina] Med Coll Wisconsin, Dept Anesthesiol, 9200 W Wisconsin Ave,P347, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Spofford, C (corresponding author), Med Coll Wisconsin, Dept Anesthesiol, 9200 W Wisconsin Ave,P347, Milwaukee, WI 53226 USA.
EM lgodhardt@mcw.edu; cspofford@mcw.edu
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NR 37
TC 44
Z9 52
U1 4
U2 40
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD JUN
PY 2022
VL 26
IS 6
BP 453
EP 458
DI 10.1007/s11916-022-01048-4
EA APR 2022
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1M1NV
UT WOS:000788410900001
PM 35482244
DA 2026-01-16
ER

PT J
AU He, YH
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   Zhang, HB
AF He, Yihan
   May, Brian H.
   Zhang, Haibo
TI Association of Acupuncture and Acupressure With Improved Cancer Pain
   Reply
SO JAMA ONCOLOGY
LA English
DT Letter
C1 [He, Yihan; Zhang, Haibo] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.
   [He, Yihan; May, Brian H.] RMIT Univ, Sch Hlth & Biomed Sci, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.
C3 Guangzhou University of Chinese Medicine; Royal Melbourne Institute of
   Technology (RMIT)
RP Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.
EM haibozh@gzucm.edu.cn
RI Zhang, Haibo/HLP-9266-2023
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NR 6
TC 0
Z9 0
U1 0
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD JUN
PY 2020
VL 6
IS 6
BP 940
EP 940
DI 10.1001/jamaoncol.2020.0640
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MA6QT
UT WOS:000542037700036
PM 32324196
DA 2026-01-16
ER

PT J
AU Xie, Y
   Li, YY
   Liu, D
   Zou, Y
   Wang, HY
   Pan, L
AF Xie, Yuan
   Li, Yuanyuan
   Liu, Di
   Zou, Yi
   Wang, Haiying
   Pan, Liang
TI Clinical rules of Acupoint selection for cancer pain opioid-induced
   constipation based on journal literature data mining: A systematic
   review
SO HELIYON
LA English
DT Article
DE Cancer pain opioid-related constipation; Data mining; Acupoint selection
   rule; Acupoint therapy
ID THERAPY
AB Objective: To analyse and summarise the regularity of acupoint selection in the treatment of opioid-induced constipation (OIC) in patients with cancer pain using a data mining technique and provide a reference for clinical practice and more valuable treatment options. Methods: The acupoint prescription database for the treatment of OIC-related cancer pain was established by searching the relevant literature on randomised controlled trials involving acupoint therapy for OIC-related cancer pain in seven major databases, including the China National Knowledge Infrastructure, Wanfang and VIP Chinese scientific journal databases, from database establishment to December 31, 2022. The main therapeutic measures of acupoint prescription, frequency of acupoint use and its subordinate meridians and subordinate sites were then analysed. Through systematic clustering and association rule analysis, the core acupoint prescriptions and most commonly used acupoint compatibility of acupoint therapy for OIC-related cancer pain were obtained. Results: A total of 649 articles were retrieved, with 72 articles included after screening. The treatment measures were found to be mainly acupoint applications involving 28 acupoints, with a total frequency of 234. The three most frequently used acupoints were Shenque, Tianshu and Zusanli. The number of points used in the Foot-Yangming stomach meridian was the highest. Commonly used acupoints were mainly distributed in the abdomen. The compatibility of two commonly used acupoints was obtained through systematic clustering. Through association rule analysis, it was found that in the compatibility of acupoints, the strongest correlation was between Tianshu and Zusanli, and their frequency of application was the highest. Conclusion: Tianshu and Zusanli are the core acupoints for acupoint therapy in the treatment of OIC-related cancer pain, and the Shangjuxu-Zhigou-Zusanli, Qihai-Guanyuan and Zhongwan-Tianshu acupoints exhibit the highest compatibility. This study provides a reference for the clinical acupoint selection programme of acupuncture and moxibustion in the treatment of OICrelated cancer pain.
C1 [Xie, Yuan; Wang, Haiying] Beijing Univ Chinese Med, Beijing 100029, Peoples R China.
   [Li, Yuanyuan; Liu, Di; Zou, Yi; Pan, Liang] Beijing Univ Chinese Med, Dept Acupuncture, Dongfang Hosp, Beijing 100078, Peoples R China.
   [Pan, Liang] Beijing Univ Chinese Med, Dept Acupuncture, Dongfang Hosp, 6 Fangxingyuan, Beijing 100078, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine
RP Pan, L (corresponding author), Beijing Univ Chinese Med, Dept Acupuncture, Dongfang Hosp, 6 Fangxingyuan, Beijing 100078, Peoples R China.
EM Pan01143@bucm.edu.cn
FU Professor Yang Jiasan's Research Office of "3 + 3 " project of Beijing
   Administration of Traditional Chinese Medicine [2023-JYB-JBZD-025];
   Fundamental Research Funds for the Central Universities;  [2007-SZ-A-12]
FX The research is sponsored by Professor Yang Jiasan's Research Office of
   "3 + 3 '' project of Beijing Administration of Traditional Chinese
   Medicine (2007-SZ-A-12) ,Fundamental Research Funds for the Central
   Universities (2023-JYB-JBZD-025) .
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NR 90
TC 0
Z9 0
U1 2
U2 13
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAR 15
PY 2024
VL 10
IS 5
AR e26170
DI 10.1016/j.heliyon.2024.e26170
EA FEB 2024
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NR2W6
UT WOS:001202125300001
PM 38439874
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tang, Y
   Yin, HY
   Lu, J
   Rubini, P
   Illes, P
AF Tang, Yong
   Yin, Hai-yan
   Lu, Juan
   Rubini, Patrizia
   Illes, Peter
TI P2X receptors and acupuncture analgesia
SO BRAIN RESEARCH BULLETIN
LA English
DT Review
DE Acupuncture analgesia; Purinergic signaling; ATP; P2X receptors
ID DORSAL-ROOT GANGLIA; NEUROPATHIC PAIN; SPINAL MICROGLIA; PURINERGIC
   RECEPTORS; INFLAMMATORY PAIN; SHAM ACUPUNCTURE; PORE FORMATION;
   UP-REGULATION; CANCER PAIN; ELECTROACUPUNCTURE
AB Purinergic signaling has recently been suggested to constitute the cellular mechanism underlying acupuncture-induced analgesia (AA). By extending the original hypothesis on endogenous opioids being released during AA, Geoffrey Bumstock and Maiken Nedergaard supplied evidence for the involvement of purinoceptors (P2 and P1/A1 receptors) in the beneficial effects of AA. In view of certain pain states (e.g. neuropathic pain) which respond only poorly to therapy with standard analgesics, as well as with respect to the numerous unwanted effects of opioids and non-steroidal anti-inflammatory drugs, it is of great significance to search for alternative therapeutic options. Because clinical studies on AA yielded sometimes heterogeneous results, it is of eminent importance to relay on experiments carried out on laboratory animals, by evaluating the data with stringent statistical methods including comparison with a sufficient number of control groups. In this review, we summarize the state of the art situation with respect to the participation of P2 receptors in AA and try to forecast how the field is likely to move forward in the future.
C1 [Tang, Yong] Chengdu Univ, Med & Nursing Sch, Chengdu 610106, Sichuan, Peoples R China.
   [Rubini, Patrizia; Illes, Peter] Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Haertelstr 16-18, D-04107 Leipzig, Germany.
   [Tang, Yong; Yin, Hai-yan; Lu, Juan; Illes, Peter] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China.
C3 Chengdu University; Leipzig University; Chengdu University of
   Traditional Chinese Medicine
RP Illes, P (corresponding author), Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Haertelstr 16-18, D-04107 Leipzig, Germany.; Tang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China.
EM tangyong@cdutcm.edu.cn; Peter.Illes@medizin.uni-leipzig.de
OI Yin, Haiyan/0000-0002-5442-5210
FU Deutsche Forschungsgemeinschaft [IL 20/21-1]; Sino-German Centre
   [GZ919]; Sichuan Provincial Administration of Foreign Affairs
   [SZD201846, SZD201731]; Science &Technology Department of Sichuan
   Province [2018HH0123]; National Natural Science Foundation of China
   [81373735, 81774437, 81704190, 81873240]; Innovative Research Team in
   University of Sichuan Province [16TD0015]
FX This work has been supported by grants from Deutsche
   Forschungsgemeinschaft (IL 20/21-1), Sino-German Centre (GZ919), Sichuan
   Provincial Administration of Foreign Affairs (SZD201846, SZD201731),
   Science &Technology Department of Sichuan Province (2018HH0123),
   National Natural Science Foundation of China (81373735, 81774437,
   81704190, 81873240) and Innovative Research Team in University of
   Sichuan Province (16TD0015).
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NR 100
TC 43
Z9 50
U1 1
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD SEP
PY 2019
VL 151
SI SI
BP 144
EP 152
DI 10.1016/j.brainresbull.2018.10.015
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IW3IG
UT WOS:000484873100016
PM 30458249
OA hybrid
DA 2026-01-16
ER

PT J
AU Smeester, BA
   Al-Gizawiy, M
   O'Brien, EE
   Ericson, ME
   Triemstra, JL
   Beitz, AJ
AF Smeester, Branden A.
   Al-Gizawiy, Mona
   O'Brien, Elaine E.
   Ericson, Marna E.
   Triemstra, Jennifer L.
   Beitz, Alvin J.
TI The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and
   Metastasis: Analysis of Different Treatment Regimens
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; PERIPHERAL-NERVE; FACTOR RECEPTOR; T-CELLS;
   ACUPUNCTURE; MODEL; PAIN; INHIBITION; EXPRESSION; REDUCTION
AB Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis. While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is little known about the effect of acupuncture treatment on tumor growth and metastasis. Here we evaluate the effects of six different electroacupuncture (EA) regimens on osteosarcoma tumor growth and metastasis in both male and female mice. The most significant positive effects were observed when EA was applied to the ST-36 acupoint twice weekly (EA-2X/3) beginning at postimplantation day 3 (PID 3). Twice weekly treatment produced robust reductions in tumor growth. Conversely, when EA was applied twice weekly (EA2X/7), starting at PID 7, there was a significant increase in tumor growth. We further demonstrate that EA-2X/3 treatment elicits significant reductions in tumor lymphatics, vasculature, and innervation. Lastly, EA-2X/3 treatment produced a marked reduction in pulmonary metastasis, thus providing evidence for EA's potential antimetastatic capabilities. Collectively, EA-2X/3 treatment was found to reduce both bone tumor growth and lung metastasis, which may be mediated in part through reductions in tumor-associated vasculature, lymphatics, and innervation.
C1 [Smeester, Branden A.] Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN 55455 USA.
   [Al-Gizawiy, Mona] Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA.
   [O'Brien, Elaine E.; Triemstra, Jennifer L.] Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, St Paul, MN 55108 USA.
   [Ericson, Marna E.] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA.
   [Ericson, Marna E.] Univ Minnesota, Ctr Drug Design, Minneapolis, MN 55455 USA.
   [Beitz, Alvin J.] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Medical College of Wisconsin; University of Minnesota System; University
   of Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities
RP Beitz, AJ (corresponding author), Univ Minnesota, Dept Vet & Biomed Sci, Room 205 Vet Med Bldg,1971 Commonwealth Ave, St Paul, MN 55108 USA.
EM beitz001@umn.edu
RI ; Smeester, Branden/E-7655-2013; ericson, marna/C-9591-2017
OI Beitz, Alvin/0000-0002-2640-2628; 
FU National Cancer Institute at NIH [5R01/CA084233]
FX This study was supported by a Grant (5R01/CA084233) from the National
   Cancer Institute at NIH. The authors would like to thank Heather
   Bainter, Josh Parker, and the histology staff for their technical
   assistance and S. Elliott for legendary hirsute guidance.
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NR 49
TC 15
Z9 19
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 387169
DI 10.1155/2013/387169
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 246OH
UT WOS:000326547800001
PM 24228059
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU He, YH
   Guo, XF
   May, BH
   Zhang, AL
   Liu, YH
   Lu, CJ
   Mao, JJ
   Xue, CC
   Zhang, HB
AF He, Yihan
   Guo, Xinfeng
   May, Brian H.
   Zhang, Anthony Lin
   Liu, Yihong
   Lu, Chuanjian
   Mao, Jun J.
   Xue, Charlie Changli
   Zhang, Haibo
TI Clinical Evidence for Association of Acupuncture and Acupressure With
   Improved Cancer Pain A Systematic Review and Meta-Analysis
SO JAMA ONCOLOGY
LA English
DT Review
ID INHIBITOR-INDUCED ARTHRALGIA; BREAST-CANCER; ALTERNATIVE MEDICINE;
   PALLIATIVE CARE; JOINT PAIN; MANAGEMENT; SYMPTOMS; THERAPY; TRIALS;
   RELIEF
AB Question Is the use of acupuncture and acupressure associated with improved cancer pain management compared with sham intervention and/or analgesic therapy alone? Findings In this systematic review of 17 randomized clinical trials and meta-analysis of 14 trials in the current English-language and Chinese-language literature, a significant association was found between real (compared with sham) acupuncture and reduced pain, and acupuncture combined with analgesic therapy was associated with decreased analgesic use. However, heterogeneity lowered the level of certainty of the evidence. Meaning This study found a moderate level of evidence that acupuncture and/or acupressure was significantly associated with lower pain intensity in patients with cancer compared with a sham control, which suggests a potential for a combination of acupuncture and acupressure to help reduce opioid doses in patients with cancer.
   This systematic review and meta-analysis provides an updated synthesis of the published randomized clinical trials into the use and advantages of acupuncture and/or acupressure among patients with cancer pain.
   Importance Research into acupuncture and acupressure and their application for cancer pain has been growing, but the findings have been inconsistent. Objective To evaluate the existing randomized clinical trials (RCTs) for evidence of the association of acupuncture and acupressure with reduction in cancer pain. Data Sources Three English-language databases (PubMed, Embase, and CINAHL) and 4 Chinese-language biomedical databases (Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang) were searched for RCTs published from database inception through March 31, 2019. Study Selection Randomized clinical trials that compared acupuncture and acupressure with a sham control, analgesic therapy, or usual care for managing cancer pain were included. Data Extraction and Synthesis Data were screened and extracted independently using predesigned forms. The quality of RCTs was appraised with the Cochrane Collaboration risk of bias tool. Random-effects modeling was used to calculate the effect sizes of included RCTs. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Main Outcomes and Measures The primary outcome was pain intensity measured by the Brief Pain Inventory, Numerical Rating Scale, Visual Analog Scale, or Verbal Rating Scale. Results A total of 17 RCTs (with 1111 patients) were included in the systematic review, and data from 14 RCTs (with 920 patients) were used in the meta-analysis. Seven sham-controlled RCTs (35%) were notable for their high quality, being judged to have a low risk of bias for all of their domains, and showed that real (compared with sham) acupuncture was associated with reduced pain intensity (mean difference [MD], -1.38 points; 95% CI, -2.13 to -0.64 points; I-2 = 81%). A favorable association was also seen when acupuncture and acupressure were combined with analgesic therapy in 6 RCTs for reducing pain intensity (MD, -1.44 points; 95% CI, -1.98 to -0.89; I-2 = 92%) and in 2 RCTs for reducing opioid dose (MD, -30.00 mg morphine equivalent daily dose; 95% CI, -37.5 mg to -22.5 mg). The evidence grade was moderate because of the substantial heterogeneity among studies. Conclusions and Relevance This systematic review and meta-analysis found that acupuncture and/or acupressure was significantly associated with reduced cancer pain and decreased use of analgesics, although the evidence level was moderate. This finding suggests that more rigorous trials are needed to identify the association of acupuncture and acupressure with specific types of cancer pain and to integrate such evidence into clinical care to reduce opioid use.
C1 [He, Yihan; Guo, Xinfeng; Liu, Yihong; Lu, Chuanjian; Xue, Charlie Changli; Zhang, Haibo] Guangdong Prov Acad Chinese Med Sci, Guangdong Prov Hosp Chinese Med, Guangzhou Univ Chinese Med, Affiliated Hosp 2, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.
   [He, Yihan; May, Brian H.; Zhang, Anthony Lin; Xue, Charlie Changli] RMIT Univ, China Australia Int Res Ctr Chinese Med, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
   [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Dept, 1275 York Ave, New York, NY 10021 USA.
C3 Guangzhou University of Chinese Medicine; Royal Melbourne Institute of
   Technology (RMIT); Memorial Sloan Kettering Cancer Center
RP Zhang, HB (corresponding author), Guangdong Prov Acad Chinese Med Sci, Guangdong Prov Hosp Chinese Med, Guangzhou Univ Chinese Med, Affiliated Hosp 2, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.; Xue, CC (corresponding author), RMIT Univ, China Australia Int Res Ctr Chinese Med, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
EM charlie.xue@rmit.edu.au; haibozh@gzucm.edu.cn
RI Xue, Charlie C/F-1244-2014; Zhang, Anthony Lin/AAR-6673-2021; Zhang,
   Haibo/HLP-9266-2023; Guo, Xinfeng/AAM-6850-2021
OI Xue, Charlie C/0000-0001-6937-9088; Zhang, Anthony
   Lin/0000-0002-0968-9380; Guo, Xinfeng/0000-0003-2699-9740
FU Specific Research Fund for TCM Science and Technology from the Guangdong
   Provincial Hospital of Chinese Medicine [YN2018QL04]; Traditional
   Chinese Medicine Bureau of Guangdong Province [20191126]; Guangdong
   Provincial Academy of Chinese Medical Sciences, RMIT University through
   the China-Australia International Research Centre for Chinese Medicine;
   National Cancer Institute [P30-CA008748]; National Cancer Institute
   [P30CA008748] Funding Source: NIH RePORTER
FX This study was supported in part by the Specific Research Fund for TCM
   Science and Technology no. YN2018QL04 from the Guangdong Provincial
   Hospital of Chinese Medicine, Research Project no. 20191126 from the
   Traditional Chinese Medicine Bureau of Guangdong Province and the
   Guangdong Provincial Academy of Chinese Medical Sciences, RMIT
   University through the China-Australia International Research Centre for
   Chinese Medicine, and grant P30-CA008748 from the National Cancer
   Institute (Dr Mao).
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NR 81
TC 293
Z9 340
U1 28
U2 335
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD FEB
PY 2020
VL 6
IS 2
BP 271
EP 278
DI 10.1001/jamaoncol.2019.5233
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KP0TR
UT WOS:000515957200017
PM 31855257
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Kuang, RQ
   Xiong, GJ
   Lv, W
   Zhao, Y
   Yu, M
   Jiang, JW
AF Kuang, Renqing
   Xiong, Guojiang
   Lv, Wei
   Zhao, Yun
   Yu, Min
   Jiang, Jiawang
TI Efficacy and safety of acupuncture combined with analgesics on lung
   cancer pain A protocol for systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE acupuncture; lung cancer; pain; protocol; systematic review
ID SYMPTOM PREVALENCE; ELECTROACUPUNCTURE; DISTRESS; TIME
AB Background: Lung cancer (LC) is the malignant tumor with the highest incidence in the world, and treatment methods include surgery, radiotherapy, chemotherapy, and immunotherapy. Cancer pain is a common symptom in patients with LC, and the clinical treatment is to relieve it with analgesics. Acupuncture can relieve cancer pain. This study aims to systematically study the efficacy and safety of acupuncture combined with analgesics on cancer pain in patients with LC.
   Methods: From the beginning to April 2021, search Medline, Embase, Cochrane Central Controlled Trials Register (Central), China National Knowledge Infrastructure (CNKI), Wanfang Database, China Biomedical Literature Database (CBM), and Chinese Science Journal Database (VIP database). Search the international clinical trial registration platform and the Chinese clinical trial registration platform to find ongoing or unpublished trials. The main outcome indicator is the total effective rate of analgesia, and the secondary outcome indicator is pain intensity score and adverse reactions. The RevMan 5.4 software will be used for statistical analysis.
   Results: This study will provide the latest evidence for acupuncture combined with analgesics to relieve LC pain.
   Conclusion: The conclusion of this study is to evaluate the effectiveness and safety of acupuncture combined with analgesics in alleviating LC pain.
C1 [Kuang, Renqing; Yu, Min; Jiang, Jiawang] Jiangxi Univ Chinese Med, Nanchang, Jiangxi, Peoples R China.
   [Xiong, Guojiang; Lv, Wei; Zhao, Yun] Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine
RP Xiong, GJ (corresponding author), Jiangxi Univ Chinese Med, Affiliated Hosp, Dept Thorac Surg, 445 Bayi Ave, Nanchang 330006, Jiangxi, Peoples R China.
EM 1160888698@qq.com
FU Traditional Chinese Medicine Research Project of Jiangxi Province
   [2019A140]
FX This study is supported by the Traditional Chinese Medicine Research
   Project of Jiangxi Province (Grant No.2019A140).
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U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN 11
PY 2021
VL 100
IS 23
AR e26225
DI 10.1097/MD.0000000000026225
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SS3FH
UT WOS:000661625000031
PM 34115008
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, QL
   Yuan, YT
   Zhang, ML
   Qiao, BH
   Cui, YY
   Wang, Y
   Feng, L
AF Zhang, Qinglin
   Yuan, Yuntong
   Zhang, Meiling
   Qiao, Baohua
   Cui, Yiyuan
   Wang, Ying
   Feng, Li
TI Efficacy and safety of acupuncture-point stimulation combined with
   opioids for the treatment of moderate to severe cancer pain: a network
   meta-analysis of randomized controlled trials
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE cancer pain; acupuncture-point stimulation; opioid; supplementary
   alternative therapy; network meta-analysis
AB Background Pain is one of the most common and troublesome symptoms of cancer. Although potential positive effects of acupuncture-point stimulation (APS) on cancer pain have been observed, knowledge regarding the selection of the optimal APS remains unclear because of a lack of evidence from head-to-head randomized controlled trials (RCTs).ObjectiveThis study aimed to carry out a network meta-analysis to compare the efficacy and safety of different APS combined with opioids in treating moderate to severe cancer pain and rank these methods for practical consideration.Methods A comprehensive search of eight electronic databases was conducted to obtain RCTs involving different APS combined with opioids for moderate to severe cancer pain. Data were screened and extracted independently using predesigned forms. The quality of RCTs was appraised with the Cochrane Collaboration risk-of-bias tool. The primary outcome was the total pain relief rate. Secondary outcomes were the total incidence of adverse reactions, the incidence of nausea and vomiting, and the incidence of constipation. We applied a frequentist, fixed-effect network meta-analysis model to pool effect sizes across trials using rate ratios (RR) with their 95% confidence intervals (CI). Network meta-analysis was performed using Stata/SE 16.0.Results We included 48 RCTs, which consisted of 4,026 patients, and investigated nine interventions. A network meta-analysis showed that a combination of APS and opioids was superior in relieving moderate to severe cancer pain and reducing the incidence of adverse reactions such as nausea, vomiting, and constipation compared to opioids alone. The ranking of total pain relief rates was as follows: fire needle (surface under the cumulative ranking curve (SUCRA) = 91.1%), body acupuncture (SUCRA = 85.0%), point embedding (SUCRA = 67.7%), auricular acupuncture (SUCRA = 53.8%), moxibustion (SUCRA = 41.9%), transcutaneous electrical acupoint stimulation (TEAS) (SUCRA = 39.0%), electroacupuncture (SUCRA = 37.4%), and wrist-ankle acupuncture (SUCRA = 34.1%). The ranking of total incidence of adverse reactions was as follows: auricular acupuncture (SUCRA = 23.3%), electroacupuncture (SUCRA = 25.1%), fire needle (SUCRA = 27.2%), point embedding (SUCRA = 42.6%), moxibustion (SUCRA = 48.2%), body acupuncture (SUCRA = 49.8%), wrist-ankle acupuncture (SUCRA = 57.8%), TEAS (SUCRA = 76.3%), and opioids alone (SUCRA = 99.7%).Conclusions APS seemed to be effective in relieving cancer pain and reducing opioid-related adverse reactions. Fire needle combined with opioids may be a promising intervention to reduce moderate to severe cancer pain as well as reduce opioid-related adverse reactions. However, the evidence was not conclusive. More high-quality trials investigating the stability of evidence levels of different interventions on cancer pain must be conducted.Systematic Review Registration, identifier CRD42022362054.
C1 [Zhang, Qinglin; Zhang, Meiling] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Oncol, Hangzhou, Peoples R China.
   [Zhang, Qinglin; Yuan, Yuntong; Qiao, Baohua; Wang, Ying] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China.
   [Zhang, Qinglin; Cui, Yiyuan; Wang, Ying; Feng, Li] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Beijing, Peoples R China.
C3 Zhejiang Chinese Medical University; Beijing University of Chinese
   Medicine; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College; Cancer Institute & Hospital -
   CAMS
RP Feng, L (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Beijing, Peoples R China.
EM fengli663@126.com
RI Zhang, Qinglin/AAA-2842-2020
FU Project of the Central Public Scientific Research Institute of Cancer
   Hospital, Chinese Academy of Medical Sciences [2019XK320072]; Special
   Research Project of the Capital Health Development [2020-2-4026]
FX Funding This research was supported by the Project of the Central Public
   Scientific Research Institute of Cancer Hospital, Chinese Academy of
   Medical Sciences (No. 2019XK320072) and the Special Research Project of
   the Capital Health Development (No. 2020-2-4026).
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NR 79
TC 4
Z9 4
U1 3
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUN 2
PY 2023
VL 13
AR 1166580
DI 10.3389/fonc.2023.1166580
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA J4FK3
UT WOS:001009184000001
PM 37333815
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, DX
   Zhao, XH
   Li, HP
   Chen, W
   Liu, CZ
AF Zhang, Dongxu
   Zhao, Xinhua
   Li, Hongping
   Chen, Wen
   Liu, Cunzhi
TI Effect of eight different acupuncture and moxibustion therapies on
   breast cancer-related lymphedema: a Bayesian network meta-analysis
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Breast cancer-related lymphedema; Acupuncture and moxibustion therapies;
   Arm circumference; Pain; Network meta-analysis
ID SURVIVORS
AB BackgroundBreast cancer is the most prevalent cancer worldwide, and nearly 30% of affected patients experience breast cancer-related lymphedema (BCRL). Some evidence suggests that acupuncture and moxibustion therapies are safe and effective in the treatment of BCRL. Nevertheless, there is controversy regarding the optimal acupuncture and moxibustion therapy for BCRL.ObjectiveThe aim of this study was to compare and rank the efficacy of different acupuncture and moxibustion therapies for BCRL, to identify the best acupuncture and moxibustion therapy for BCRL, and to provide a reference for clinicians to choose the treatment modality.MethodsWe searched PubMed, Embase, Cochrane Library, Web of Science, Google Scholar, China National Knowledge Infrastructure, CQVIP, Wanfang Data, and SINOMED Databases for randomized controlled trials (RCTs) of acupuncture and moxibustion therapy for BCRL from inception to March 30, 2023. The quality of the included literature was assessed using the Cochrane risk of bias assessment, and data were analyzed and plotted using R4.3.2 and Stata 15.1 software.ResultsWe included 27 RCTs including 8 acupuncture interventions with a sample size of 1976 cases. The results of the network meta-analysis showed that acupuncture + moxibustion, moxibustion, blood-letting puncture and cupping, and electroacupuncture combined with conventional rehabilitation were superior to conventional rehabilitation alone in reducing arm circumference. Moxibustion combined with conventional rehabilitation was superior to conventional rehabilitation alone in reducing the degree of edema. Electroacupuncture and acupoint massage combined with conventional rehabilitation were superior to conventional rehabilitation alone in reducing the visual analogue scale (VAS) scores. And in terms of improving the mobility of the shoulder joint, moxibustion and electroacupuncture combined with conventional rehabilitation were better than conventional rehabilitation alone.ConclusionThe combination of acupuncture and moxibustion therapy with conventional rehabilitation can improve the efficacy of BCRL. Acupuncture + moxibustion was the best treatment modality to reduce arm circumference, acupuncture was the best modality to reduce edema, and electroacupuncture was the most effective modality for relieving BCRL pain symptoms and was the best choice to improve abduction range of motion (ROM). Due to the limitations of this study, this conclusion remains to be validated by further high-quality clinical studies.
C1 [Zhang, Dongxu; Li, Hongping; Chen, Wen; Liu, Cunzhi] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Zhao, Xinhua] Beijing Anorectal Hosp, Tumor Ctr, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine
RP Liu, CZ (corresponding author), Beijing Univ Chinese Med, Beijing, Peoples R China.
EM lcz623780@126.com
RI li, hongping/JBR-8611-2023
FU National Key Research and Development Program
FX Thanks to all the authors for their collaboration in this study. We
   thank the valuable suggestions from other members of our research group.
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NR 74
TC 0
Z9 0
U1 7
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD SEP 13
PY 2025
VL 33
IS 10
AR 850
DI 10.1007/s00520-025-09861-4
PG 17
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 7GJ9V
UT WOS:001570397400003
PM 40944772
DA 2026-01-16
ER

PT J
AU Yang, M
   Chen, Y
   Wan, YX
   Shen, C
   Huang, JC
AF Yang, Ming
   Chen, Yue
   Wan, Yuxiang
   Shen, Chen
   Huang, Jinchang
TI Acupuncture and moxibustion in integrative oncology and new progress in
   China
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Review
DE Acupuncture; Moxibustion; Integrative oncology; Evidence-based medicine;
   Traditional Chinese Medicine
ID ELECTRICAL ACUPOINT STIMULATION; CANCER-RELATED FATIGUE; BREAST-CANCER;
   DOUBLE-BLIND; AURICULAR ACUPUNCTURE; ONS GUIDELINES(TM); GASTRIC-CANCER;
   HOT FLASHES; PAIN; XEROSTOMIA
AB Acupuncture and moxibustion are increasingly gaining recognition in the clinical and research fields of integrative oncology. This review synthesizes findings from clinical guidelines, systematic reviews, meta-analyses, and randomized controlled trials (RCTs) of acupuncture and moxibustion for cancer care. Clinical evidence highlights acupuncture's efficacy in managing symptoms such as hot flashes, pain, insomnia, fatigue, and constipation. Acupuncture also demonstrates potential effects in reducing chemotherapy and radiotherapy-induced side effects. Recent advancements in China shows integrated therapies combining acupuncture with chemotherapy to enhance therapeutic outcomes. Additionally, laboratory studies reveal the potential of acupuncture and moxibustion to modulate the tumor microenvironment, boost chemotherapy efficacy, and strengthen immunity. Despite these promising results, there is a pressing need for well-designed trials and real-world studies to evaluate the long-term effects of standardized acupuncture and moxibustion treatments in cancer care.
C1 [Yang, Ming; Chen, Yue; Wan, Yuxiang; Huang, Jinchang] Beijing Univ Chinese Med, Affiliated Hosp 3, An Wai Xiao Guan Jie 51, Beijing 100029, Peoples R China.
   [Shen, Chen] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Huang, JC (corresponding author), Beijing Univ Chinese Med, Affiliated Hosp 3, An Wai Xiao Guan Jie 51, Beijing 100029, Peoples R China.
EM zryhhuang@163.com
RI Wan, Yuxiang/AAU-9771-2020
OI Wan, Yuxiang/0000-0003-0778-551X
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NR 98
TC 1
Z9 1
U1 11
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD JUN
PY 2025
VL 14
IS 2
AR 101149
DI 10.1016/j.imr.2025.101149
EA MAY 2025
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2TY1A
UT WOS:001491235900001
PM 40475037
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lam, TY
   Lu, LM
   Ling, WM
   Lin, LZ
AF Lam, To-Yi
   Lu, Li-Ming
   Ling, Wai-Man
   Lin, Li-Zhu
TI A pilot randomized controlled trial of acupuncture at the Si Guan
   Xue for cancer pain
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Acupuncture; Si guan Xue; Cancer pain; Randomized controlled trial
AB Background: Pain is a common symptom in cancer patients. Acupuncture is a suggested treatment for a wide range of clinical conditions, usually for its beneficial effects on pain control. Si guan xue (the four points) have been widely used in clinical practice, and has shown that it is highly effective, effective in obtaining qi, shows strong acupuncture stimulation, and is simple to manipulate and safe to use. Therefore, the aim of this study is to test the protocol and safety of acupuncture at the si guan xue in the management of cancer pain.
   Methods: This is a single-blind, randomized controlled pilot trial. 42 patients with moderate to severe cancer pain were randomly assigned to three different arms with seven sessions of treatment; that is, treatment arm 1 (the si guan xue arm, n = 14), treatment arm 2 (the si guan xue plus commonly used acupoints arm, n = 14) and the control arm (the commonly used acupoints arm n = 14). Primary outcomes included acupuncture relieving cancer pain, and patients' subjective improvement as measured by the Patient Global Impression of Change (PGIC). Secondary outcomes included the scores of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and Karnofsky's Performance Status (KPS).
   Results: The analysis showed that the cancer pain reduction in treatment arm 2 was most prominent on day 5 when compared with the control arm (P<0.05). There was no difference in the scores of PGIC, EORTC QLQ-C30 or KPS among the three groups (P>0.05). Furthermore, no serious adverse events were observed.
   Conclusions: These results indicate that acupuncture at the si guan xue plus commonly used acupoints tends to be effective in reducing cancer pain. However, the sample size was small, and a future multi-centre study with a larger sample size is warranted.
C1 [Lam, To-Yi; Lin, Li-Zhu] Guangzhou Univ Chinese Med, Dept Oncol, Guangzhou 510405, Guangdong, Peoples R China.
   [Lu, Li-Ming] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China.
   [Ling, Wai-Man] Pamela Youde Nethersole Eastern Hosp, Dept Clin Oncol, 3 Lok Man Rd, Chaiwan, Hong Kong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Pamela Youde Nethersole Eastern Hospital
RP Lin, LZ (corresponding author), Guangzhou Univ Chinese Med, Dept Oncol, Guangzhou 510405, Guangdong, Peoples R China.
EM lizhulin903@139.com
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NR 42
TC 14
Z9 23
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUN 26
PY 2017
VL 17
AR 335
DI 10.1186/s12906-017-1838-5
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EY6RR
UT WOS:000404111400001
PM 28651642
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, ZD
   Wang, CS
   Gu, GY
   Li, HP
   Zhao, HF
   Wang, K
   Han, F
   Wang, GN
AF Zhang, Zhaodi
   Wang, Changsong
   Gu, Guangying
   Li, Huiping
   Zhao, Haifang
   Wang, Kun
   Han, Fei
   Wang, Guonian
TI The Effects of Electroacupuncture at the ST36 (Zusanli) Acupoint on
   Cancer Pain and Transient Receptor Potential Vanilloid Subfamily 1
   Expression in Walker 256 Tumor-Baearing Rats
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID LOW-FREQUENCY ELECTROACUPUNCTURE; INDUCED INFLAMMATORY PAIN;
   POSTOPERATIVE PAIN; NEUROPATHIC PAIN; ANALGESIC REQUIREMENT; MECHANICAL
   ALLODYNIA; MESSENGER-RNA; MODEL; HYPERALGESIA; TRPV1
AB BACKGROUND: Several studies have addressed the expression of transient receptor potential vanilloid subfamily 1(TRPV1) playing an important role in the generation of cancer pain. Electroacupuncture (EA) is an effective method of acupuncture shown to attenuate different kinds of pain such as inflammatory, neuropathic, and cancer. In this study, we investigated the effect of EA on cancer pain caused by intraplantar injection of Walker 256 carcinoma cells and cancer-driven TRPV1 expression in the dorsal root ganglions (DRGs).
   METHODS: Rats were randomly divided into 4 groups: the nontumor cell inoculation group (normal control, n = 8); Walker 256 carcinoma cell inoculation group (tumor control, n = 8); sham point electrical stimulation treatment with Walker 256 carcinoma cell inoculation group (SES, n = 8); EA treatment with Walker 256 carcinoma cell inoculation group (EA, n = 8). The time courses of thermal, mechanical sensitivity, and spontaneous nocifensive behavior were determined. In addition, TRPV1 expression in DRGs was observed by quantitative real-time polymerase chain reaction and Western blotting.
   RESULTS: Injection of cancer cells decreased the paw withdrawal threshold, increased spontaneous nocifensive behavior, and induced significant thermal hyperalgesia that was attenuated by EA at the ST36 acupoint (2 Hz, 0.3 ms, <= 1 mA). TRPV1 mRNA and protein in DRGs were upregulated in the cancer pain model, and EA at ST36 acupoint counteracted the cancer-driven upregulation of TRPV1 expression in the corresponding DRGs.
   CONCLUSIONS: EA at ST36 could attenuate cancer-induced pain, at least in part, through suppressing TRPV1 mRNA and protein upregulation in the DRGs. (Anesth Analg 2012;114:879-85)
C1 [Zhang, Zhaodi; Gu, Guangying; Zhao, Haifang; Wang, Kun; Han, Fei; Wang, Guonian] Harbin Med Univ, Affiliated Hosp 3, Dept Anesthesiol, Harbin 150081, Peoples R China.
   [Wang, Changsong] Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin 150081, Peoples R China.
   [Li, Huiping] Harbin Med Univ, Dept Anat, Harbin 150081, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Wang, GN (corresponding author), Harbin Med Univ, Affiliated Hosp 3, Dept Anesthesiol, 6 Baojian Rd, Harbin 150081, Peoples R China.
EM guonian_wang@yahoo.cn
RI ; Wang, Guonian/HPH-8253-2023
OI wang, changsong/0000-0002-0079-5259; 
FU Outstanding Youth Science Foundation [JC2007716]; Education Bureau of
   Heilongjiang Province of China [1152hz33]
FX This research was supported by funds from the Outstanding Youth Science
   Foundation (no. JC2007716), and the Important Research Project of
   Education Bureau of Heilongjiang Province of China (no. 1152hz33).
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NR 49
TC 43
Z9 51
U1 2
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-2999
J9 ANESTH ANALG
JI Anesth. Analg.
PD APR
PY 2012
VL 114
IS 4
BP 879
EP 885
DI 10.1213/ANE.0b013e318246536d
PG 7
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA 912UL
UT WOS:000301826800026
PM 22253272
DA 2026-01-16
ER

PT J
AU Jeong, JH
   Song, JY
   Jo, HG
   Kim, JM
   Yoon, SS
   Park, C
   Kim, S
   Roh, SS
   Lee, BH
   Yang, CH
   Kim, HY
AF Jeong, Jong-Ho
   Song, Joo-Young
   Jo, Hyo-Gwon
   Kim, Ji-Min
   Yoon, Samuel-S.
   Park, Chul
   Kim, Seunghyun
   Roh, Seong-Soo
   Lee, Bong Hyo
   Yang, Chae Ha
   Kim, Hee Young
TI Simple Acupoints Prescription Flow Chart Based on Meridian Theory: A
   Retrospective Study in 102 Dogs
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INTERVERTEBRAL-DISK DISEASE; ACUPUNCTURE PRETREATMENT;
   MYOCARDIAL-ISCHEMIA; MANUAL ACUPUNCTURE; ELECTROACUPUNCTURE; RATS;
   NAUSEA; ACUPRESSURE; CANCER; GV01
AB To help the clinicians prescribe acupoints easily and effectively, we developed one simple flow chart to select acupoints. This study aimed to evaluate the usefulness of flow chart to select acupoints in dogs. Total 102 dogs showing intervertebral disc disease (IVDD) (n = 12), vomiting (n = 11), diarrhea (n = 2), abdominal pain (n = 5), cough (n = 66), or epilepsy (n = 6) received acupuncture treatment according to the chart, and its outcomes were evaluated as regards clinical symptoms, duration, treatment numbers, and recovery time. Dogs (8/8) with IVDD from grades I to III recovered over periods of 5 days to 6 weeks after 1-12 treatments, while 1/4 dogs with grade IV recovered over 7 weeks after 15 treatments. Vomiting dogs with acute/subacute (n = 8) and chronic symptoms (n = 3) required about 1 and 7 treatments to recover fully, respectively. All dogs (n = 5) with abdominal pain showed fast relief within 24 hours after acupuncture. Two diarrhea cases recovered over 2-9 days after 1-2 treatments. Fifty-four of 66 coughing dogs were recovered by 1-2 treatments. And 5 of 6 epilepsy dogs under a regular acupuncture treatment had no epileptic episode during followup of 12 months. These results suggest that this flow chart can help the clinicians prescribe acupoints effectively.
C1 [Jeong, Jong-Ho] Boo Young Anim Hosp, Namyangju Si 472080, Gyeonggi Do, South Korea.
   [Song, Joo-Young] Sarang Anim Hosp, Seoul 152053, South Korea.
   [Jo, Hyo-Gwon] Jakjeon 24 Hour Anim Hosp, Incheonsi 407060, Gyeonggi Do, South Korea.
   [Kim, Ji-Min] Jun Anim Hosp, Anyangsi 431088, Gyeonggi Do, South Korea.
   [Yoon, Samuel-S.] Twin City Anim Hosp, Fitchburg, MA 01420 USA.
   [Park, Chul] Chonbuk Natl Univ, Dept Vet Internal Med, Coll Vet Med, Jeonju Si 561756, Jeollabuk Do, South Korea.
   [Kim, Seunghyun; Roh, Seong-Soo; Lee, Bong Hyo; Yang, Chae Ha] Daegu Haany Univ, Coll Korean Med, Taegu 706828, South Korea.
   [Kim, Hee Young] Daegu Haany Univ, Dept Physiol, Coll Korean Med, Taegu 706828, South Korea.
C3 Jeonbuk National University; Daegu Haany University; Daegu Haany
   University
RP Kim, HY (corresponding author), Daegu Haany Univ, Dept Physiol, Coll Korean Med, Taegu 706828, South Korea.
EM hykim@dhu.ac.kr
FU National Research Foundation of Korea (NRF); Korea Government (MEST)
   [20120009400]; International Veterinary Acupuncture Society (IVAS) via
   the Grady Young Memorial Scholarship program
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government (MEST) (no. 20120009400). The
   authors thank Phil Rogers MRCVS, Dublin, for editing the material in
   this paper. Hee Young Kim also appreciates and acknowledges the support
   for the basic course on veterinary acupuncture (2007-2008, San Antonio,
   USA) provided by the International Veterinary Acupuncture Society (IVAS)
   via the Grady Young Memorial Scholarship program.
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NR 82
TC 2
Z9 3
U1 1
U2 32
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 129315
DI 10.1155/2013/129315
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 157UD
UT WOS:000319923800001
PM 23762103
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Li, XX
   Wang, R
   Shi, XE
   Su, JL
   Pan, YQ
   Tian, JH
   Yang, KH
AF Li, Xiuxia
   Wang, Rong
   Shi, Xiue
   Su, Jinlong
   Pan, Yuanqing
   Tian, Jinhui
   Yang, Kehu
TI Reporting Characteristics and Quality of Systematic Reviews of
   Acupuncture Analgesia
SO PAIN PRACTICE
LA English
DT Review
DE acupuncture analgesia; systematic reviews; characteristics; quality
ID RANDOMIZED CONTROLLED-TRIALS; PAIN; METAANALYSIS; BIAS
AB Background: Evaluating the clinical efficacy of acupuncture analgesia with systematic reviews (SRs) has attracted wide interest.
   Objective: To collect a sample of published SRs on acupuncture analgesia in PubMed and examine them in terms of reporting characteristics and quality.
   Methods: A search in PubMed was performed in January 2016. All SRs on acupuncture analgesia were included. To assess the quality of the SRs, AMSTAR tool and PRISMA Statements were used.
   Results: One hundred and nine SRs were included in our analysis, the yearly number of publications ranging from 1 in 1997 to 15 in 2015. Only 17% of these publications were Cochrane Systematic Reviews, and 94% were published in Science Citation Index journals. The United Kingdom was the country with the higher number of publications. Low back pain, headache, cancer pain, and labor pain were the most reported diseases or phenotypes. Nearly 73% of these SRs conducted a meta-analysis, 58% revealed positive results, 53% used RevMan software to analyze data, and 44% used the Cochrane Risk of Bias Tool for quality assessment. Only a few SRs assessed the likelihood of publication bias, reported details about the protocol and the registration information, and performed additional analyses.
   Conclusions: The quantity and the quality of SRs regarding acupuncture analgesia have been promoted in recent years. More effort should be expended on the assessment of publication bias, the provision of detailed information about the protocol and the registration process, and the implementation of additional analyses to improve the validity of the SRs.
C1 [Li, Xiuxia; Pan, Yuanqing; Tian, Jinhui; Yang, Kehu] Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China.
   [Li, Xiuxia; Pan, Yuanqing; Tian, Jinhui; Yang, Kehu] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Gansu, Peoples R China.
   [Wang, Rong] Gansu Univ Chinese Med, Lanzhou, Gansu, Peoples R China.
   [Wang, Rong] PLA, Dept Orthoped, Gen Hosp, Lanzhou, Gansu, Peoples R China.
   [Shi, Xiue] Rehabil Ctr Hosp Gansu Prov, Lanzhou, Gansu, Peoples R China.
   [Su, Jinlong] Lanzhou Univ, Pharmaceut Ctr, Hosp 2, Lanzhou, Gansu, Peoples R China.
C3 Lanzhou University; Gansu University of Chinese Medicine; Lanzhou
   University
RP Yang, KH (corresponding author), Lanzhou Univ, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM kehuyangebm2006@126.com
OI Yang, Hehu/0000-0001-7864-3012
CR [Anonymous], 1997, NIH Consens Statement, V15, P1
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NR 30
TC 9
Z9 12
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1530-7085
EI 1533-2500
J9 PAIN PRACT
JI Pain Pract.
PD NOV
PY 2017
VL 17
IS 8
BP 1066
EP 1074
DI 10.1111/papr.12555
PG 9
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA FM1BB
UT WOS:000414704300010
PM 28083991
DA 2026-01-16
ER

PT J
AU Ali, U
   Apryani, E
   Ahsan, MZ
   Shoaib, RM
   Ahmad, KA
   Wang, YX
AF Ali, Usman
   Apryani, Evhy
   Ahsan, Muhammad Zaeem
   Shoaib, Rana Muhammad
   Ahmad, Khalil Ali
   Wang Yong-xiang
TI Acupuncture/Electroacupuncture as an Alternative in Current Opioid
   Crisis
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE analgesia; Chinese medicine; electroacupuncture; acupuncture; opioid
   crisis
ID NEUROPATHIC PAIN; POSTOPERATIVE PAIN; SPINAL MICROGLIA; M2 MACROPHAGES;
   CANCER PAIN; RAT MODEL; ELECTROACUPUNCTURE; ACUPUNCTURE; RECEPTOR;
   EPIDEMIC
AB Opioid drugs are the first line of defense in severe pain but the adverse effects associated with opioids are considered as a serious issue worldwide. Acupuncture/electroacupuncture is a type of Chinese medicine therapy which is an effective analgesic therapy, well documented in animals and human studies. Electroacupuncture stimulation could release endogenous opioid peptides causing analgesia in a variety of pain models. It can be used as an alternative therapy to control the opioid crisis.
C1 [Ali, Usman; Apryani, Evhy; Ahsan, Muhammad Zaeem; Shoaib, Rana Muhammad; Ahmad, Khalil Ali; Wang Yong-xiang] Shanghai Jiao Tong Univ, Sch Pharm, Kings Lab, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wang, YX (corresponding author), Shanghai Jiao Tong Univ, Sch Pharm, Kings Lab, Shanghai 200240, Peoples R China.
EM yxwang@sjtu.edu.cn
RI Shoaib, Rana Muhammad/HOC-4067-2023; Kasm, Khalil Ali
   Ahmad/HMV-3083-2023; Ali, Usman/GRX-4193-2022; Ahsan, Muhammad
   Zaeem/GRF-3151-2022
OI Kasm, Khalil Ali Ahmad/0000-0002-8133-2319; Ali,
   Usman/0000-0002-8943-3536; Ahsan, Muhammad Zaeem/0000-0002-7367-3818
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NR 65
TC 24
Z9 28
U1 2
U2 46
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD SEP
PY 2020
VL 26
IS 9
BP 643
EP 647
DI 10.1007/s11655-019-3175-7
EA OCT 2019
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA NF2SH
UT WOS:000491940100002
PM 31630362
DA 2026-01-16
ER

PT J
AU Chen, H
   Liu, TY
   Kuai, L
   Zhu, J
   Wu, CJ
   Liu, LM
AF Chen, Hao
   Liu, Tang-Yi
   Kuai, Le
   Zhu, Ji
   Wu, Cai-Jun
   Liu, Lu-Ming
TI Electroacupuncture treatment for pancreatic cancer pain: A randomized
   controlled trial
SO PANCREATOLOGY
LA English
DT Article
DE Pancreatic cancer; Pain; Electroacupuncture
ID CLINICAL-TRIALS; ACUPUNCTURE; CARE; EFFICACY; FUTURE; WORLD
AB Background: Pancreatic cancer is often accompanied by severe abdominal or back pain. It's the first study to evaluate the analgesic effect of electroacupuncture on pancreatic cancer pain. A randomized controlled trial compared electroacupuncture with control acupuncture using the placebo needle.
   Methods: Sixty patients with pancreatic cancer pain were randomly assigned to the electroacupuncture group (n = 30) and the placebo control group (n = 30). Patients were treated on Jiaji (Ex-B2) points T8-T12 bilaterally for 30 min once a day for 3 days. Pain intensity was assessed with numerical rated scales (NRS) before the treatment (Baseline), after 3 treatments, and 2 days follow-up.
   Results: Baseline characteristics were similar in the two groups. After 3 treatment, pain intensity on NRS decreased compared with Baseline (-1.67, 95% confidence interval [CI] -1.46 to -1.87) in the electroacupuncture group; there was little change (-0.13, 95% CI 0.08 to -0.35) in control group; the difference between two groups was statistically significant (P < 0.001). Follow-up also found a significant reduction in pain intensity in the electroacupuncture group compared with the control group (P < 0.001).
   Conclusions: Electroacupuncture was an effective treatment for relieving pancreatic cancer pain. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
C1 [Chen, Hao; Zhu, Ji; Wu, Cai-Jun; Liu, Lu-Ming] Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai 200433, Peoples R China.
   [Liu, Tang-Yi; Kuai, Le] Shanghai Univ Tradit Chinese Med, Coll Acupuncture & Tuina, Shanghai 200032, Peoples R China.
C3 Fudan University; Shanghai University of Traditional Chinese Medicine
RP Kuai, L (corresponding author), Shanghai Univ Tradit Chinese Med, Coll Acupuncture & Tuina, 1200 Cai Lun Rd, Shanghai 200032, Peoples R China.
EM happykuai2004@msn.com
RI Liu, Tangyi/LIC-6895-2024; Zhu, Ji/HDM-1538-2022
OI Zhu, Ji/0000-0001-7134-9419
FU National Natural Science Foundation of China (NSFC) [81202751]; Shanghai
   Science and Technology Committee [12401905600]
FX This study was supported jointly by the National Natural Science
   Foundation of China (NSFC) (81202751 to Le Kuai), and Shanghai Science
   and Technology Committee (12401905600 to Hao Chen).
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
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NR 28
TC 57
Z9 69
U1 1
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1424-3903
EI 1424-3911
J9 PANCREATOLOGY
JI Pancreatology
PD NOV-DEC
PY 2013
VL 13
IS 6
BP 594
EP 597
DI 10.1016/j.pan.2013.10.007
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 270JC
UT WOS:000328313700008
PM 24280575
DA 2026-01-16
ER

PT J
AU Sun, LY
   Ramalingam, MB
   Baser, R
   Teles, MS
   Seluzicki, C
   Li, QS
   Mao, JJ
AF Sun, Lingyun
   Ramalingam, Mothi Babu
   Baser, Raymond
   Santos Teles, Marco
   Seluzicki, Christina
   Li, Qing Susan
   Mao, Jun J.
TI Acupuncture Improves Functional Limitations for Cancer Patients with
   Chronic Pain: A Secondary Analysis of PEACE Randomized Clinical Trial
SO CURRENT ONCOLOGY
LA English
DT Article
DE cancer pain; acupuncture; rehabilitation; extremity function; randomized
   controlled trial
ID QUALITY-OF-LIFE; BREAST-CANCER; SURVIVAL; REHABILITATION; METAANALYSIS;
   MEDICINE; THERAPY; WOMEN
AB Chronic pain significantly impairs functional performance in patients with cancer. Although acupuncture is effective for cancer-related pain, its impact on pain-related functional interference remains unclear. This secondary analysis of the PEACE randomized clinical trial included patients with prior cancer diagnoses and musculoskeletal pain for >= 3 months. Participants were randomized to groups undergoing 10 weeks of electro-acupuncture, auricular acupuncture, or a waitlist control. Functional performance was assessed using the Quick-Disability Arm/Shoulder/Hand (Q-DASH) for upper limbs and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscale for lower limbs (higher scores = worse function). Linear mixed models compared changes over time between groups, with week 12 as the primary endpoint. Functional changes were also compared between pain responders and non-responders in the acupuncture arms. Among 360 patients (mean [SD] age, 62.1 [12.7] years; 69.7% women), mean baseline Q-DASH and WOMAC scores were 33.2 (19.8) and 33.3 (20.3). At week 12, both electro-acupuncture and auricular acupuncture significantly improved function versus waitlist: Q-DASH by -7.18 and -9.64 points, respectively, and WOMAC by -6.89 and -7.61 points (all p < 0.001). No differences were found between the two acupuncture groups. Treatment effects on Q-DASH diminished during follow-up, while improvements on WOMAC persisted. Within the acupuncture groups, pain responders achieved greater functional gains than non-responders (Q-DASH, -6.74; WOMAC, -6.16; both p < 0.001). Electro-acupuncture and auricular acupuncture improved upper and lower extremity function in cancer patients with chronic pain. These findings support acupuncture as a potential adjunct in functional rehabilitation for cancer survivors.
C1 [Sun, Lingyun] China Acad Chinese Med Sci, Xiyuan Hosp, Oncol Dept, Beijing 100091, Peoples R China.
   [Sun, Lingyun; Santos Teles, Marco; Seluzicki, Christina; Li, Qing Susan; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.
   [Ramalingam, Mothi Babu] Singapore Gen Hosp, Dept Rehabil Med, Singapore 169856, Singapore.
   [Baser, Raymond] Mem Sloan Kettering Canc Ctr, Epidemiol Biostat, New York, NY 60637 USA.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Memorial Sloan Kettering Cancer Center; Singapore General Hospital;
   Memorial Sloan Kettering Cancer Center
RP Sun, LY (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Oncol Dept, Beijing 100091, Peoples R China.; Sun, LY; Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.
EM slyslysun@126.com; maoj@mskcc.org
OI Mao, Jun/0000-0001-9229-0380
FU Department of Defense office of the Congressionally Directed Medical
   Research Programs [W81XWH-15-1-0245]; Scientific and Technological
   Innovation Project of the China Academy of Chinese Medical Science
   [C12021A01819]; National Cancer Institute Cancer Center Support Grant
   (CCSG) [P30 CA008748]
FX This research was supported by the Scientific and Technological
   Innovation Project of the China Academy of Chinese Medical Science
   (C12021A01819) and the Department of Defense office of the
   Congressionally Directed Medical Research Programs through the
   Peer-Reviewed Medical Research Program Clinical Trial Award
   (W81XWH-15-1-0245). This work was also supported in part by a National
   Cancer Institute Cancer Center Support Grant (CCSG) (P30 CA008748) to
   Memorial Sloan Kettering Cancer Center.
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1198-0052
EI 1718-7729
J9 CURR ONCOL
JI Curr. Oncol.
PD NOV 16
PY 2025
VL 32
IS 11
AR 640
DI 10.3390/curroncol32110640
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA H4223
UT WOS:001625529600001
PM 41294702
OA gold
DA 2026-01-16
ER

PT J
AU Xie, YH
   Ma, J
   Wang, D
   Chai, XQ
   Gao, C
AF Xie, Yanhu
   Ma, Jun
   Wang, Di
   Chai, Xiaoqing
   Gao, Chen
TI Electro-acupuncture stimulation prevents remifentanil-induced
   postoperative by peralgesia by suppressing spinal microglia in rats
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE electro-acupuncture; remifentanil; postoperative hyperalgesia;
   pro-inflammatory cytokines; microglia
ID OPIOID-INDUCED HYPERALGESIA; INFLAMMATORY PAIN; NEUROPATHIC PAIN; MODEL;
   ACUPUNCTURE; RECEPTORS; CONTRIBUTES; ACTIVATION; ANESTHESIA; FENTANYL
AB The aim of the present study was to assess the effect of electro-acupuncture (EA) stimulation on remifentanil-induced postoperative hyperalgesia (RIPH) and the possible involvement of spinal microglia suppression. A model of RIPH was established using adult male Sprague-Dawley rats by administration of remifentanil at 0.08 mg/kg intravenously for 60 min. The Huantiao and Yanglingquan acupoints were stimulated continuously by EA (2 Hz, similar to 1 mA) for 90 min from before paw incision to the end of remifentanil administration. Sham acupoints were stimulated by EA in the sham group. paw withdrawal threshold (PWT) and paw thermal withdrawal latency (PWL) were determined. Cluster of differentiation (CD)11b, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 levels in spinal cord samples were measured using immunohistochemistry and ELISA. PWT and PWL values were decreased following the administration of remifentanill; however, following EA, PWT and PWL, values increased compared with the sham group (P<0.05), indicating that EA alleviates remifentanil-induced RIPH. CD11b, TNF-alpha, IL-1 beta and IL-6 levels were increased following remifentanil administration and these effects were counteracted by EA (all P<0.05). In the sham group, no significant differences were observed in PWT and PWL values or CD11b, TNF-alpha, IL-beta and IL-6 levels compared with the control group, suggesting that EA was responsible for the reduction in CD11b and pro-inflammatory cytokine expression following remifentanil administration. The results of the present study demonstrated that EA at the Huantiao and Yanglingquan acupoints may reduce remifentanil-induced postoperative hyperalgesia, likely by inhibiting spinal microglia via reduction of CD11b and pro-inflammatory cytokine expression. However, these results are preliminary and require further validation.
C1 [Xie, Yanhu; Ma, Jun; Wang, Di; Chai, Xiaoqing; Gao, Chen] Anhui Med Univ, Anhui Prov Hosp, Dept Anesthesiol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China.
C3 Anhui Medical University
RP Chai, XQ (corresponding author), Anhui Med Univ, Anhui Prov Hosp, Dept Anesthesiol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China.
EM 2660747430@qq.com
FU Department of Health of Anhui Province [2012zy45]
FX The present study was supported by the Department of Health of Anhui
   Province (grant no. 2012zy45).
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NR 44
TC 7
Z9 10
U1 1
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2018
VL 16
IS 1
BP 353
EP 359
DI 10.3892/etm.2018.6161
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GL4IZ
UT WOS:000437115500050
PM 29896261
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Booher, A
   Mao, JJ
   Muniz, RC
   Romero, SAD
   Li, SQ
   Lopez, AM
   Liou, KT
AF Booher, Allison
   Mao, Jun J.
   Muniz, Rosario Costas
   Romero, Sally A. D.
   Li, Susan Q.
   Lopez, Ana Maria
   Liou, Kevin T.
TI Association between Hispanic Ethnicity and Greater Expectation of
   Benefit from Acupuncture or Massage for Pain in Cancer
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Cancer; Pain; Acupuncture; Massage; Integrative medicine; Health equity;
   Hispanic; Latino; Latina; Ethnic disparities
ID MANAGEMENT
AB Individuals living with cancer and survivors of cancer who self-identify as Hispanic experience higher pain burden and greater barriers to pain management compared with their non-Hispanic counterparts. The Society for Integrative Oncology-ASCO guideline recommends acupuncture and massage for cancer pain management. However, Hispanic individuals' expectations about these modalities remain under-studied and highlight a potential barrier to treatment utilization in this population. We conducted a subgroup analysis of baseline data from two randomized clinical trials to evaluate ethnic differences in treatment expectations about integrative pain treatment modalities among Hispanic and non-Hispanic cancer patients and survivors of cancer. The Mao Expectancy of Treatment Effects (METE) instrument was used to measure treatment expectancy for electro-acupuncture, auricular acupuncture, and massage therapy. Results of this study demonstrated that Hispanic participants reported greater expectation of benefit from electroacupuncture, auricular acupuncture, and massage (all P < 0.01). After controlling for age, gender, race, and education, Hispanic ethnicity remained significantly associated with greater expectation of benefit from integrative therapies for pain (coef.=1.47, 95% CI, 0.67-2.27). Non-white race (coef.=1.04, 95% CI, 0.42-1.65), no college education (coef.=1.16, 95% CI, 0.59-1.74), and female gender (coef.=0.94, 95% CI, 0.38-1.50) were also associated with a greater expectation of benefit from integrative therapies. Pain management should be informed by a shared decision-making approach that aligns treatment expectancy with treatment selections to optimize outcomes. Compared with non-Hispanic participants, Hispanic individuals reported higher expectation of benefit from acupuncture and massage, highlighting the potential role for integrative therapies in addressing ethnic pain disparities.
C1 [Booher, Allison] Geisel Sch Med Dartmouth, Hanover, NH USA.
   [Mao, Jun J.; Li, Susan Q.; Liou, Kevin T.] Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,4th Floor, New York, NY 10065 USA.
   [Muniz, Rosario Costas] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY USA.
   [Romero, Sally A. D.] Univ Calif San Diego, Dept Obstet Gynecol & Reprod Sci, San Diego, CA USA.
   [Lopez, Ana Maria] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA USA.
C3 Dartmouth College; Memorial Sloan Kettering Cancer Center; Memorial
   Sloan Kettering Cancer Center; University of California System;
   University of California San Diego; Thomas Jefferson University
RP Liou, KT (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,4th Floor, New York, NY 10065 USA.
EM allison.g.booher.med@dartmouth.edu; maoj@mskcc.org; costasmr@mskcc.org;
   saromero@health.ucsd.edu; liq2@mskcc.org; anamaria.lopez@jefferson.edu;
   liouk@mskcc.org
OI Lopez, Ana Maria/0000-0002-2759-5353; Romero, Sally/0000-0001-6028-4111;
   Liou, Kevin/0000-0002-2438-9749; , Allison Booher/0009-0001-5935-4773;
   Mao, Jun/0000-0001-9229-0380
FU NCI NIH HHS [P30 CA008748, 5R25CA020449, K08 CA266927, R25 CA020449]
   Funding Source: Medline; NIH HHS [P30-CA008748-53] Funding Source:
   Medline; Patient-Centered Outcomes Research Institute
   [SMPAI-2018C2-12883] Funding Source: Medline; U.S. Department of Defense
   [W81XWH-15-1-0245] Funding Source: Medline
CR Burleson MH, 2019, J SOC PERS RELAT, V36, P1000, DOI 10.1177/0265407517750005
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Keefe JR, 2017, J PSYCHIATR RES, V84, P90, DOI 10.1016/j.jpsychires.2016.09.029
   Lopez M. H., WHO IS HISPANIC
   Mao JJ, 2022, J CLIN ONCOL, V40, P3998, DOI 10.1200/JCO.22.01357
   Mao JJ, 2021, JAMA ONCOL, V7, P720, DOI 10.1001/jamaoncol.2021.0310
   Mao JJ, 2010, ALTERN THER HEALTH M, V16, P22
   Romero SAD, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-058281
   Samuel CA, 2020, QUAL LIFE RES, V29, P2615, DOI 10.1007/s11136-020-02527-0
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NR 10
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD OCT
PY 2024
VL 26
IS 5
BP 953
EP 957
DI 10.1007/s10903-024-01611-8
EA JUL 2024
PG 5
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA G3Z2D
UT WOS:001265407900001
PM 38977653
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Ouyang, BS
   Gao, J
   Che, JL
   Zhang, Y
   Li, J
   Yang, HZ
   Hu, TY
   Yang, M
   Wu, YJ
   Ji, LL
AF Ouyang Ba-si
   Gao Jie
   Che Jian-li
   Zhang Yin
   Li Jun
   Yang Hai-zhou
   Hu Tian-yan
   Yang Man
   Wu Yuan-jian
   Ji Ling-ling
TI Effect of electro-acupuncture on tumor necrosis factor-α and vascular
   endothelial growth factor in peripheral blood and joint synovia of
   patients with rheumatoid arthritis
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE electro-acupuncture; needling; rheumatoid arthritis; tumor necrosis
   factor; vascular endothelial growth factor
ID CYTOKINES
AB To observe the effect of electro-acupuncture (EA) on tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in peripheral blood and joint synovia in patients with rheumatoid arthritis (RA) to verify the clinical efficacy of EA.
   Adopting randomized controlled principle, the 63 RA patients enrolled were assigned to two groups, the 32 patients in the EA group were treated with EA, and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method, the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day, 10 times as a course, and each patient received a total of 3 courses of treatment.
   Blood and synovial levels of TNF-alpha and VEGF were reduced significantly after treatment in both groups. The lowering (absolute value and difference value) of TNF-alpha as well as the absolute value of VEGF, either in blood or in synovia, were similar in the two groups (P > 0.05); but the lowering of VEGF after treatment was more significant in the EA group than that in the SN group (P < 0.05).
   EA could effectively lower the contents of TNF-alpha and VEGF in peripheral blood and joint synovia to improve the internal environment for genesis and development of RA, so as to enhance the clinical therapeutic effectiveness.
C1 [Ouyang Ba-si; Gao Jie; Zhang Yin; Li Jun; Yang Hai-zhou] Suzhou Hosp Tradit Chinese Med, Suzhou 215003, Jiangsu Prov, Peoples R China.
   [Che Jian-li] Soochow Univ, Affiliated Hosp 1, Suzhou 215007, Jiangsu Prov, Peoples R China.
   [Hu Tian-yan] Soochow Univ, Childrens Hosp, Suzhou 215003, Jiangsu Prov, Peoples R China.
   [Yang Man; Wu Yuan-jian; Ji Ling-ling] Nanjing Univ Tradit Chinese Med, Nanjing 210009, Peoples R China.
C3 Soochow University - China; Soochow University - China; Nanjing
   University of Chinese Medicine
RP Ouyang, BS (corresponding author), Suzhou Hosp Tradit Chinese Med, Suzhou 215003, Jiangsu Prov, Peoples R China.
EM oybasi@163.com
FU Suzhou Municipal Developing Plan of Sciences and Technology (Social
   Development and Three-drug Keystone) [SS0528]
FX Supported by the Suzhou Municipal Developing Plan of Sciences and
   Technology (Social Development and Three-drug Keystone, No. SS0528)
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NR 13
TC 43
Z9 57
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1672-0415
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD JUL
PY 2011
VL 17
IS 7
BP 505
EP 509
DI 10.1007/s11655-011-0783-2
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 786KA
UT WOS:000292305400004
PM 21725875
DA 2026-01-16
ER

PT J
AU Hsiung, WT
   Chang, YC
   Yeh, ML
   Chang, YH
AF Hsiung, Wan-Ting
   Chang, Yi-Chuan
   Yeh, Mei-Ling
   Chang, Yung-Hsien
TI Acupressure improves the postoperative comfort of gastric cancer
   patients: A randomised controlled trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Acupressure; Postoperative comfort; Gastric cancer; Pain; Nausea;
   Vomiting; Flatus; Defecation
ID ACUPOINT ELECTRICAL-STIMULATION; GASTROINTESTINAL MOTILITY; CONTROLLED
   ANALGESIA; CAPSICUM PLASTER; PAIN; NAUSEA; ACUPUNCTURE; SURGERY;
   ACUSTIMULATION; DECOMPRESSION
AB Objective: This pilot study evaluated whether acupressure affected the postoperative comfort of gastric cancer patients following a subtotal gastrectomy.
   Methods: A randomised controlled trial was conducted. Sixty patients were recruited from 141-bed general surgery ward at a 3000-bed medical centre in Northern Taiwan. Participants were randomly assigned to either a control group receiving regular postoperative care or to the experimental group receiving additional acupressure at acupoints of Neiquan (P6) and Zusanli (ST36) for 3 consecutive days.
   Results: The similarities between two groups were in postoperative pain and the onset of postoperative nausea and vomiting (PONV) at the baseline. Following acupressure, significant differences were found in postoperative pain (P=.03) and time of first flatus (P=.04); but not PONV (P=.49), nor the time of first defecation (P=.34).
   Conclusions: Acupressure is a simple, noninvasive, safe, and economical procedure for improving the comfort of patients who undergo surgery for gastric cancer. Acupressure at the P6 and ST36 acupoints can improve postoperative comfort by alleviating pain and decreasing the time until first flatus. However, additional research is necessary to elucidate how acupressure can improve postoperative outcomes. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Hsiung, Wan-Ting] Taipei Vet Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Chang, Yi-Chuan] Fooyin Univ, Dept Nursing, Kaohsiung, Taiwan.
   [Chang, Yi-Chuan] Natl Taipei Univ Nursing & Hlth Sci, Taipei, Taiwan.
   [Yeh, Mei-Ling] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taipei, Taiwan.
   [Chang, Yung-Hsien] China Med Univ & Hosp, Taichung, Taiwan.
C3 Taipei Veterans General Hospital; Fooyin University; National Taipei
   University of Nursing & Health Science (NTUNHS); National Taipei
   University of Nursing & Health Science (NTUNHS); China Medical
   University Taiwan; China Medical University Hospital - Taiwan
RP Yeh, ML (corresponding author), Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, 365 Minte Rd, Taipei, Taiwan.
EM meiling@ntunhs.edu.tw
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NR 53
TC 37
Z9 42
U1 0
U2 37
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2015
VL 23
IS 3
BP 339
EP 346
DI 10.1016/j.ctim.2015.03.010
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CL5JZ
UT WOS:000356997500005
PM 26051568
DA 2026-01-16
ER

PT J
AU Zhang, JL
   Yang, MX
   So, TH
   Chang, TY
   Qin, ZS
   Chen, HY
   Lam, WL
   Yeung, WF
   Chung, KF
   Jiang, F
   Lao, LX
   Zhang, ZJ
AF Zhang, Jialing
   Yang, Mingxiao
   So, Tsz Him
   Chang, Tien Yee
   Qin, Zongshi
   Chen, Haiyong
   Lam, Wing Lok
   Yeung, Wing Fai
   Chung, Ka Fai
   Jiang, Fei
   Lao, Lixing
   Zhang, Zhang-Jin
TI Electroacupuncture Plus Auricular Acupressure on Chemotherapy-Related
   Insomnia in Patients With Breast Cancer (EACRI): Study Protocol for a
   Randomized, Sham-Controlled Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE insomnia; breast cancer; chemotherapy; electroacupuncture; auricular
   acupressure; sham control
ID COGNITIVE-BEHAVIORAL THERAPY; SLEEP QUALITY INDEX; HOSPITAL ANXIETY;
   CHINESE VERSION; CANTONESE-VERSION; SEVERITY INDEX; FACT-B; ACUPUNCTURE;
   VALIDATION; PAIN
AB Objective Insomnia is a highly prevalent and disturbing symptom in breast cancer patients under or post chemotherapy. If not appropriately treated, it can persist for years after the completion of cancer treatments. Acupuncture has been widely used for alleviating insomnia. The aim of this study is to examine the feasibility, efficacy and safety of acupuncture for chemotherapy-related insomnia among patients with breast cancer. Materials and Methods This is a trial protocol for a randomized, sham-controlled, subject- and assessor-blinded clinical trial. A total of 138 eligible participants will be assigned randomly to acupuncture or sham control group at a ratio of 1:1. Participants in acupuncture group will receive electroacupuncture (EA) plus auricular acupressure (AA) treatment, while subjects in sham acupuncture group will receive sham EA plus sham AA. Both acupuncture and sham treatments will be given twice weekly for 6 weeks, followed by maintenance treatments once every 4 weeks for 12 weeks (15 sessions totally). The primary outcome is the change of Insomnia Severity Index score between baseline and the end of 6-week treatment. Secondary outcome measurements include Actiwatch, sleep diary, Pittsburgh Sleep Quality Index, Functional Assessment of Cancer Therapy-Breast Cancer, Hospital Anxiety and Depression Scale, Brief Pain Inventory-Short Form, Brief Fatigue Inventory, Acupuncture Expectancy Scale, credibility, and adverse events. Participants will be followed up to 42 weeks. Conclusions This trial will expand our understanding of the feasibility, efficacy, and safety of acupuncture as a treatment for alleviating chemotherapy-related insomnia in patients with breast cancer. EA plus AA, if proven to be effective, can be implemented into routine settings to play a role in insomnia management for patients with breast cancer.
C1 [Zhang, Jialing; Zhang, Zhang-Jin] Univ Hong Kong, Shenzhen Hosp HKU SZH, Dept Chinese Med, Shenzhen, Guangdong, Peoples R China.
   [Zhang, Jialing; Yang, Mingxiao; Qin, Zongshi; Chen, Haiyong; Lam, Wing Lok; Lao, Lixing; Zhang, Zhang-Jin] Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
   [So, Tsz Him; Chang, Tien Yee] Univ Hong Kong, LKS Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Chang, Tien Yee] Hong Kong Sanat Hosp, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Yeung, Wing Fai] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Chung, Ka Fai] Univ Hong Kong, LKS Fac Med, Dept Psychiat, Hong Kong, Peoples R China.
   [Jiang, Fei] Univ Hong Kong, Dept Stat & Actuarial Sci, Hong Kong, Peoples R China.
   [Lao, Lixing] Virginia Univ Integrat Med, 9401 Mathy Dr, Fairfax, VA 22031 USA.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong; Hong Kong Polytechnic University; University of Hong Kong;
   University of Hong Kong
RP Lao, LX (corresponding author), Virginia Univ Integrat Med, 9401 Mathy Dr, Fairfax, VA 22031 USA.; Zhang, ZJ (corresponding author), Univ Hong Kong, Sch Chinese Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.
EM llao@vuim.edu; zhangzj@hku.hk
RI So, Tsz-him/U-1240-2019; CHEN, Haiyong/G-6787-2014; Yang,
   Mingxiao/ABF-6416-2021; Qin, Zongshi/ABE-2821-2021; ZHANG,
   Jialing/IAN-2737-2023; ZHANG, ZHANG-JIN/ORK-0709-2025; Jiang,
   Fei/AAH-4755-2019; Lao, Lixing/P-9107-2019; Yeung, Wing-Fai/E-7971-2013
OI CHEN, Haiyong/0000-0002-4889-2752; Yang, Mingxiao/0000-0002-6514-3366;
   Qin, Zongshi/0000-0001-5888-461X; ZHANG, Jialing/0000-0003-0900-4617; 
FU National Key R&D Program of China [2018YFC1705801]; Health and Medical
   Research Fund, Government of the Hong Kong Special Administrative Region
   of China Health and Medical Research Fund [16172761]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This trial
   is funded by National Key R&D Program of China (Ref no: 2018YFC1705801),
   and Health and Medical Research Fund, Government of the Hong Kong
   Special Administrative Region of China Health and Medical Research Fund
   (Ref no: 16172761). The funding bodies are not involved in the study
   design and conduct, data collection, management, analysis, and
   interpretation.
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NR 60
TC 6
Z9 6
U1 3
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD NOV
PY 2021
VL 20
AR 15347354211058695
DI 10.1177/15347354211058695
PG 11
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Integrative & Complementary Medicine
GA XB9CY
UT WOS:000721620000001
PM 34802291
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Deng, G
   Bao, T
   Mao, JJ
AF Deng, Gary
   Bao, Ting
   Mao, Jun J.
TI Understanding the Benefits of Acupuncture Treatment for Cancer Pain
   Management
SO ONCOLOGY-NEW YORK
LA English
DT Article
ID INDUCED PERIPHERAL NEUROPATHY; CLINICAL-PRACTICE GUIDELINES;
   BREAST-CANCER; AMERICAN SOCIETY; CHEMOTHERAPY; TRIAL;
   ELECTROACUPUNCTURE; METAANALYSIS; ARTHRALGIA; PREVENTION
AB This article summarizes the current evidence regarding the use of acupuncture for pain management in cancer patients. It includes a description of how acupuncture is thought to work and what the intervention entails, data on acupuncture for managing pain caused by cancer or by cancer treatment (radiation, chemotherapy, endocrine therapy), how acupuncture is practiced in the US medical system, discussion of safety issues, and practical tips on how to integrate acupuncture into cancer care.
C1 [Deng, Gary; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10017 USA.
   [Bao, Ting] Mem Sloan Kettering Canc Ctr, Integrat Breast Oncol, 1275 York Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
RP Deng, G (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10017 USA.
EM dengg@mskcc.org
OI Bao, Ting/0000-0003-4437-2597
FU National Institutes of Health/National Cancer Institute Cancer Center
   [P30 CA008748]; National Cancer Institute [P30CA008748] Funding Source:
   NIH RePORTER
FX The authors' work on acupuncture for cancer pain has been supported by
   funding from the National Institutes of Health/National Cancer Institute
   Cancer Center Support Grant P30 CA008748.
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NR 43
TC 22
Z9 24
U1 0
U2 23
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
J9 ONCOLOGY-NY
JI Oncology-NY
PD JUN
PY 2018
VL 32
IS 6
BP 310
EP 316
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GJ7RG
UT WOS:000435586000009
PM 29940063
DA 2026-01-16
ER

PT J
AU Li, CY
   Zhao, C
   Zhao, JJ
   Wang, M
   Luo, FR
   Zhou, JW
AF Li, Chunyu
   Zhao, Can
   Zhao, Jingjing
   Wang, Min
   Luo, Furong
   Zhou, Jianwei
TI Global research trends of acupuncture therapy on cancer pain: A
   bibliometric and visualized study
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE acupuncture; cancer pain; bibliometric analysis; VOSviewer; web of
   science
ID INDUCED PERIPHERAL NEUROPATHY; INHIBITOR-RELATED ARTHRALGIA; EARLY
   BREAST-CANCER; ELECTROACUPUNCTURE; CHEMOTHERAPY; TRIAL; WOMEN;
   MECHANISMS; SYMPTOMS; MANAGEMENT
AB Background The number of publications on acupuncture for cancer pain is increasing rapidly with an upward tendency. Considering that no bibliometric articles related to this topic have been published yet. It is necessary to evaluate the global scientific output of research in this field, and shed light on the direction of clinical cancer pain management in the future.Methods Research publications regarding acupuncture on cancer pain from inception to 2022 were downloaded from the Web of Science Core Collection. Bibliometric analyses were performed using CiteSpace software, the bibliometrix R package, and VOSviewer software. Network maps were generated to assess the collaborations between different countries, institutions, authors, and keywords. And clusters map was generated to evaluate reference.Results A total of 790 articles related to acupuncture therapy for cancer pain were identified. We observe that the number of publications is gradually increasing over time. China and the United States were the main contributors. Mem Sloan Kettering Canc Ctr (38 papers) and Beijing Univ Chinese Med (28 papers) contributed the most publications, becoming the leading contributors in this field. Although J Clin Oncol (28 articles) ranked ninth in terms of publication volume, it was the journal with the most citations and the highest number of IF (50.717) and H-index (494) at the same time. MAO J from Mem Sloan Kettering Canc Ctr was the most prolific author (23 articles). The main hot topics included matters related to acupuncture (239 times), pain (199 times), management (139 times), quality of life (107 times), electroacupuncture (100 times), and breast cancer (82 times).Conclusion Our bibliometric analysis provides a comprehensive overview of the development of acupuncture for cancer pain, enabling relevant authors and research teams to identify the current research status in this field. At the same time, acupuncture for breast cancer (BC) pain, aromatase inhibitor-induced arthralgia (AIA), and chemotherapy-induced peripheral neuropathy (CIPN) may soon become prospective focus.
C1 [Li, Chunyu] Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
   [Zhao, Can] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Sichuan, Peoples R China.
   [Zhao, Jingjing; Wang, Min] Sichuan Second Hosp Tradit Chinese Med, Dept Acupuncture, Chengdu, Sichuan, Peoples R China.
   [Luo, Furong] Northwest Univ, Xian Hosp 3, Dept Tradit Chinese Med, Affiliated Hosp, Xian, Shanxi, Peoples R China.
   [Zhou, Jianwei] Sichuan Acad Chinese Med Sci, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Northwest University Xi'an
RP Zhou, JW (corresponding author), Sichuan Acad Chinese Med Sci, Chengdu, Sichuan, Peoples R China.
EM Jianweizhou126@126.com
FU project of Sichuan Provincial Administration of traditional Chinese
   Medicine [2021ZD02]
FX This study was supported by the project of Sichuan Provincial
   Administration of traditional Chinese Medicine (NO.2021ZD02).
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NR 62
TC 4
Z9 5
U1 2
U2 49
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD MAR 6
PY 2023
VL 13
AR 1077961
DI 10.3389/fonc.2023.1077961
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA A6IU8
UT WOS:000956146400001
PM 36950556
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kutcher, AM
   LeBaron, VT
AF Kutcher, Anna M.
   LeBaron, Virginia T.
TI Evaluating Acupuncture for the Treatment of Chemotherapy-induced
   Peripheral Neuropathy: An Integrative Review
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Review
DE acupuncture; electro-acupuncture; chemotherapy-induced peripheral
   neuropathy; integrative oncology; cancer; integrative review
ID ELECTROACUPUNCTURE; CANCER; PREVENTION; MANAGEMENT; SURVIVORS; EFFICACY;
   ONCOLOGY; TRIAL; RISK
AB The purpose of this integrative review of the literature is to synthesize the current evidence and identify gaps in knowledge regarding the effectiveness of acupuncture to treat chemotherapy-induced peripheral neuropathy (CIPN). PubMed, CINAHL, Web of Science, and Cochrane Review databases were searched using inclusion criteria: keywords acupuncture, cancer, and peripheral neuropathy, published in English, between 2009 and 2019. Sixteen articles met the inclusion criteria. The literature indicates that acupuncture is generally well tolerated by patients with cancer, and a majority of patients with CIPN reported decreased pain and increased quality of life after receiving acupuncture treatment. A comprehensive understanding of the ability of acupuncture to treat CIPN is limited by variability of acupuncture techniques and inconsistency in measures of evaluation.
C1 [Kutcher, Anna M.; LeBaron, Virginia T.] Univ Virginia, Sch Nursing, 225 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
C3 University of Virginia
RP Kutcher, AM (corresponding author), Univ Virginia, Sch Nursing, 225 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
EM amn7r@virginia.edu
OI Kutcher, Anna/0000-0001-6982-628X
CR Bao T, 2018, EUR J CANCER, V101, P12, DOI 10.1016/j.ejca.2018.06.008
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NR 42
TC 10
Z9 11
U1 2
U2 28
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0193-9459
EI 1552-8456
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD FEB
PY 2022
VL 44
IS 2
BP 169
EP 179
AR 0193945921992538
DI 10.1177/0193945921992538
EA FEB 2021
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA YJ5CV
UT WOS:000626207200001
PM 33559535
DA 2026-01-16
ER

PT J
AU Ju, ZY
   Cui, HS
   Guo, XH
   Yang, HY
   He, JS
   Wang, K
AF Ju, Ziyong
   Cui, Huashun
   Guo, Xiaohui
   Yang, Huayuan
   He, Jinsen
   Wang, Ke
TI Molecular mechanisms underlying the effects of acupuncture on
   neuropathic pain
SO NEURAL REGENERATION RESEARCH
LA English
DT Article
DE neural regeneration; acupuncture; neuropathic pain; chronic constriction
   injury; electroacupuncture; spinal dorsal horn; ephrin-B/EphB signaling;
   nerve repair; grants-supported paper; neuroregeneration
ID SPINAL NERVE LIGATION; RANDOMIZED CONTROLLED-TRIAL; ACTIVATED
   PROTEIN-KINASE; DORSAL-ROOT GANGLION; BONE CANCER PAIN; MANUAL
   ACUPUNCTURE; CORD-INJURY; FREQUENCY ELECTROACUPUNCTURE;
   CLINICAL-APPLICATIONS; CELL-PROLIFERATION
AB Acupuncture has been used to treat neuropathic pain for a long time, but its mechanisms of action remain unknown. In this study, we observed the effects of electroacupuncture and manual acupuncture on neuropathic pain and on ephrin-B/EphB signaling in rats models of chronic constriction injury-induced neuropathic pain. The results showed that manual acupuncture and electroacupuncture significantly reduced mechanical hypersensitivity following chronic constriction injury, especially electroacupuncture treatment. Real-time PCR results revealed that ephrin-B1/B3 and EphB1/B2 mRNA expression levels were significantly increased in the spinal dorsal horns of chronic constriction injury rats. Electroacupuncture and manual acupuncture suppressed the high expression of ephrin-B1 mRNA, and elevated EphB3/B4 mRNA expression. Electroacupuncture significantly enhanced the mRNA expression of ephrin-B3 and EphB3/B6 in the dorsal horns of neuropathic pain rats. Western blot results revealed that electroacupuncture in particular, and manual acupuncture, significantly up-regulated ephrin-B3 protein levels in rat spinal dorsal horns. The results of this study suggest that acupuncture could activate ephrin-B/EphB signaling in neuropathic pain rats and improve neurological function.
C1 [Ju, Ziyong; Guo, Xiaohui; Yang, Huayuan; He, Jinsen] Shanghai Univ Tradit Chinese Med, Coll Acumox & Tuina, Shanghai 201203, Peoples R China.
   [Cui, Huashun] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Acupuncture, Shanghai 201203, Peoples R China.
   [Wang, Ke] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Cardiothorac Surg, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP He, JS (corresponding author), Shanghai Univ Tradit Chinese Med, Coll Acumox & Tuina, Shanghai 201203, Peoples R China.
EM hejinsen@citiz.net; wangke8430@163.com
RI ; Wang, Ke/JXN-9969-2024
OI Ju, Ziyong/0000-0001-5823-2232; 
FU China Postdoctoral Science Foundation [20100480643]; Program of Shanghai
   Municipal Education Commission [2011JW13]
FX This study was supported by the China Postdoctoral Science Foundation,
   No. 20100480643; and the Program of Shanghai Municipal Education
   Commission, No. 2011JW13.
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NR 74
TC 14
Z9 21
U1 0
U2 41
PU SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
PI SHENYANG
PA PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA
SN 1673-5374
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD SEP
PY 2013
VL 8
IS 25
BP 2350
EP 2359
DI 10.3969/j.issn.1673-5374.2013.25.006
PG 10
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA 229CL
UT WOS:000325239300006
PM 25206545
DA 2026-01-16
ER

PT J
AU Liao, HY
   Satyanarayanan, SK
   Lin, YW
   Su, KP
AF Liao, Hsien-Yin
   Satyanarayanan, Senthil Kumaran
   Lin, Yi-Wen
   Su, Kuan-Pin
TI Clinical efficacy and immune effects of acupuncture in patients with
   comorbid chronic pain and major depression disorder: A double-blinded,
   randomized controlled crossover study
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Acupuncture; Chronic pain; Major depression disorder; Comorbidity;
   Biomarkers; Inflammatory cytokines
ID LOW-BACK-PAIN; CONTROLLED-TRIAL; ADENOSINE PATHWAYS; INFLAMMATORY PAIN;
   ISCHEMIC-STROKE; ELECTROACUPUNCTURE; NEUROINFLAMMATION; METAANALYSIS;
   MULTICENTER; MODEL
AB Background: Depression and pain are highly comorbid and share biological mechanisms. Acupuncture is commonly used to manage both pain and depression, but the choice of acupoints for specific disorders differs. This study aimed to investigate whether specific acupuncture intervention on pain-and depression-acupoints would have specific efficacy and immune effects in patients with comorbid chronic pain and major depressive disorder (MDD). Methods: We performed a subject-and assessor-blinded, crossover, and randomized controlled clinical trial of depression-and pain-specific acupuncture intervention and measured clinical responses and proinflammatory cytokines in patients with comorbid chronic pain and MDD. Specific acupoints for pain and depression were used in random order with a washout interval. Forty-seven patients were enrolled and randomly assigned to two groups: (1) the depression-pain group (23 patients who were treated with depression-specific acupoints and then the pain-specific acupoints after the washout) and (2) pain-depression group (24 patients with the reverse order). Results: The pain-specific acupoints for pain did not reduce Brief Pain Inventory scores to a significantly greater degree (-0.97 +/- 1.69) than the depression-specific acupoints (-0.28 +/- 1.88); likewise, the depression-specific acupoints did not significantly ameliorate Hamilton Depression Rating Scale (-4.59 +/- 6.02) than the pain-specific acupoints (-6.69 +/- 6.61). The pain-specific acupoints improved Beck Depression Inventory-Second Edition (-6.74 +/- 9.76) even better than the depression-specific acupoints (-1.92 +/- 10.74). The depression-specific acupoints did not significantly decrease the depression-related interleukin (IL)-6 level (-1.24 +/- 6.67) than the pain-specific acupoints (-0.60 +/- 4.36). The changed levels of IL-1 beta, tumor necrosis factor (TNF)-alpha be-tween the depression-specific acupoints (-37.41 +/- 194.49;-12.53 +/- 54.68) and the pain-specific acupoints (-15.46 +/- 87.56;-7.28 +/- 27.86) could not reach significantly different, too. Conclusion: This study rejected our hypothesis that the pain-specific acupoints might produce superior analgesic effects than the depression-specific acupoints and vice versa. The cytokine results might imply that pain and depression share common biological mechanisms. (trial registration: https://www.clinicaltrials.gov: NCT03328819).
C1 [Liao, Hsien-Yin] China Med Univ, Coll Chinese Med, Sch Postbaccalaureate Chinese Med, Taichung 40402, Taiwan.
   [Liao, Hsien-Yin] China Med Univ Hosp, Dept Acupuncture, Taichung 40402, Taiwan.
   [Lin, Yi-Wen] China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 40402, Taiwan.
   [Lin, Yi-Wen] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
   [Satyanarayanan, Senthil Kumaran; Su, Kuan-Pin] China Med Univ Hosp, Mind Body Interface Res Ctr, MBI Lab, Taichung, Taiwan.
   [Su, Kuan-Pin] China Med Univ, Coll Med, Taichung, Taiwan.
   [Su, Kuan-Pin] China Med Univ, An Nan Hosp, Depress Ctr, Tainan, Taiwan.
   [Lin, Yi-Wen; Su, Kuan-Pin] China Med Univ, Coll Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Taiwan; China Medical University Taiwan
RP Lin, YW; Su, KP (corresponding author), China Med Univ, Coll Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM yiwenlin@mail.cmu.edu.tw; cobolsu@gmail.com
RI Satyanarayanan, Senthil Kumaran/AAE-8015-2019
OI Satyanarayanan, Senthil Kumaran/0000-0002-0513-4943
FU Ministry of Science and Technology, Taiwan [MOST 109-2314-B-039-042,
   109-2320-B-038-057-MY3, 110-2321-B-006-004, 111-2321-B-006-008,
   110-2811-B-039-507, 111-2320-B-039-043, 110-2320-B-039-048-MY2,
   110-2320-B-039-047-MY3, 110-2813-C-039-327-B, 110-2314-B-039-029-MY3,
   111-2314-B-039-041-MY3]; An-Nan Hospital, China Medical Univer-sity,
   Tainan, Taiwan [110-13, 110-26, 110-44, 110-45, 111-27, 111-28, 111-47,
   111-48, 111-52, CMRC-CMA-2, HHC-111-8]; Higher Education Sprout Project
   by the Ministry of Education (MOE) , Taiwan [CMU 110-AWARD-02]; Chinese
   Medicine Research Center, China Medical University [110-N-17,
   1110-SR-73, ANHRF 109-31]; China Medical University, Taichung, Taiwan
   [DMR-112-174];  [109-40];  [DMR 106-101];  [106-227];  [109-102]; 
   [109-244];  [HHC-109-11];  [HHC-109-12];  [HHC-110-10];  [110-124]; 
   [DMR-110-193];  [111-245]
FX The authors of this work were supported by the following grants: MOST
   109-2314-B-039-042, 109-2320-B-038-057-MY3, 110-2321-B-006-004,
   111-2321-B-006-008, 110-2811-B-039-507, 111-2320-B-039-043,
   110-2320-B-039-048-MY2, 110-2320-B-039-047-MY3, 110-2813-C-039-327-B,
   110-2314-B-039-029-MY3, and 111-2314-B-039-041-MY3 from the Ministry of
   Science and Technology, Taiwan; ANHRF 109-31, 109-40, 110-13, 110-26,
   110-44, 110-45, 111-27, 111-28, 111-47, 111-48, and 111-52 from An-Nan
   Hospital, China Medical University, Tainan, Taiwan; CMRC-CMA-2 from
   Higher Education Sprout Project by the Ministry of Education (MOE) ,
   Taiwan; Chinese Medicine Research Center, China Medical University (The
   Featured Areas Research Center Program within the framework of the
   Higher Education Sprout Project by the Ministry of Education in Taiwan)
   ; CMU 110-AWARD-02, 110-N-17, 1110-SR-73 from the China Medical
   University, Taichung, Taiwan; and DMR 106-101, 106-227, 109-102,
   109-244, HHC-109-11, HHC-109-12, HHC-110-10, 110-124, DMR-110-193,
   111-245, HHC-111-8, and DMR-112-174 from the China Medical University
   Hospital, Taichung, Taiwan.
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NR 42
TC 37
Z9 42
U1 5
U2 41
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2023
VL 110
BP 339
EP 347
DI 10.1016/j.bbi.2023.03.016
EA MAR 2023
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA D0LR2
UT WOS:000965732900001
PM 36948325
DA 2026-01-16
ER

PT J
AU Li, SS
   Tu, WZ
   Jia, CQ
   Jiang, X
   Qian, XR
   Yang, GH
   Hu, QM
   Chen, WC
   Lu, B
   Jiang, SH
AF Li, Si-Si
   Tu, Wen-Zhan
   Jia, Cheng-Qian
   Jiang, Xia
   Qian, Xin-Ru
   Yang, Guan-Hu
   Hu, Qi-Miao
   Chen, Wen-Ci
   Lu, Bin
   Jiang, Song-He
TI KCC2-GABAA pathway correlates with the analgesic effect of
   electro-acupuncture in CCI rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE electro-acupuncture; KCC2; GABAA receptor; chronic constriction injury;
   analgesic
ID CATION-CHLORIDE-COTRANSPORTERS; CENTRAL-NERVOUS-SYSTEM;
   TUMOR-NECROSIS-FACTOR; GABA-A-RECEPTOR; NEUROPATHIC PAIN;
   GENE-EXPRESSION; ANION GRADIENT; DORSAL-HORN; NEURONS; MECHANISMS
AB Potassium-chloride cotransporter 2 (KCC2) has been indicated to serve a crucial role during chronic neuropathic pain (NP). Following the emergence of NP, gamma-aminobutyric acid (GABA) A receptor-mediated signaling may be further impaired by the changes of KCC2 chloride anion gradient. In the present study, the authors investigate the effect of electro-acupuncture (EA) on the behavior and the expression of KCC2 and GABAA receptor gamma(2) subunit in the spinal cord of chronic constriction injury (CCI) model rats. A total of 60 adult male Sprague-Dawley rats were divided into four groups: Normal group, sham-CCI group, CCI group and CCI+EA group. The effect of EA was assessed via the values of mechanical withdrawal threshold and thermal withdrawal latency, which were significantly improved upon stimulation of the ST-36 and GB-34 acupoints. In addition, a marked reduction in both the mRNA and protein levels of KCC2 and GABAA receptor gamma(2) subunit was observed in the spinal cord following loose ligation of the sciatic nerve. The reductions in KCC2 and GABAA receptor gamma(2) subunit expression were reversed by EA treatment. These results support the notion that KCC2 and GABAA receptor gamma(2) subunit contribute to NP following peripheral nerve injury and extend the understanding of the analgesic effects of EA on NP.
C1 [Li, Si-Si; Tu, Wen-Zhan; Jia, Cheng-Qian; Jiang, Xia; Hu, Qi-Miao; Chen, Wen-Ci; Jiang, Song-He] Wenzhou Med Univ, Dept Phys Med & Rehabil, Affiliated Hosp 2, 268 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Li, Si-Si; Tu, Wen-Zhan; Jia, Cheng-Qian; Jiang, Xia; Hu, Qi-Miao; Chen, Wen-Ci; Jiang, Song-He] Wenzhou Med Univ, Yuying Childrens Hosp, 268 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Tu, Wen-Zhan; Qian, Xin-Ru; Yang, Guan-Hu; Jiang, Song-He] Wenzhou Med Univ, Integrat & Optimized Med Res Ctr, China US Inst Acupuncture & Rehabil, Wenzhou 325027, Zhejiang, Peoples R China.
   [Qian, Xin-Ru] NYU, Langone Med Ctr, Dept Rehabil, 550 1St Ave, New York, NY 10016 USA.
   [Yang, Guan-Hu] Ohio Univ, Dept Specialty Med, Athens, OH 45701 USA.
   [Lu, Bin] Wenzhou Med Univ, Sch Life Sci, Attardi Inst Mitochondrial Biomed, Prot Qual Control & Dis Lab, Wenzhou 325035, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; NYU Langone Medical Center; New York University; University
   System of Ohio; Ohio University; Wenzhou Medical University
RP Jiang, SH (corresponding author), Wenzhou Med Univ, Dept Phys Med & Rehabil, Affiliated Hosp 2, 268 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Jiang, SH (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, 268 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Lu, B (corresponding author), Wenzhou Med Univ, Sch Life Sci, Attardi Inst Mitochondrial Biomed, Prot Qual Control & Dis Lab, Wenzhou 325035, Zhejiang, Peoples R China.
EM lubmito@wmu.edu.cn; songhe.jiang@gmail.com
RI Hu, qimiao/NYT-1144-2025; Lu, Bin/GQQ-3590-2022; Yang,
   GuangHu/ABH-5800-2022
FU Natural Science Foundation of Zhejiang Province [LY16H270016];
   Foundation of Wenzhou Scientific and Technological Bureau Project
   [Y20140221]
FX The current study was supported by the Natural Science Foundation of
   Zhejiang Province (grant no. LY16H270016) and the Foundation of Wenzhou
   Scientific and Technological Bureau Project (grant no. Y20140221).
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NR 37
TC 19
Z9 22
U1 0
U2 10
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2018
VL 17
IS 5
BP 6961
EP 6968
DI 10.3892/mmr.2018.8766
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GD5OR
UT WOS:000430556800096
PM 29568893
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Jiang, X
   Tian, YH
   Xu, L
   Zhang, QL
   Wan, YX
   Qi, XW
   Li, B
   Guo, J
   Sun, WL
   Luo, AP
   Huang, JC
   Gu, XH
AF Jiang, Xin
   Tian, Yehong
   Xu, Lin
   Zhang, Qiaoli
   Wan, Yuxiang
   Qi, Xuewei
   Li, Bo
   Guo, Jing
   Sun, Weiliang
   Luo, Aiping
   Huang, Jinchang
   Gu, Xiaohong
TI Inhibition of Triple-Negative Breast Cancer Tumor Growth by
   Electroacupuncture with Encircled Needling and Its Mechanisms in a Mice
   Xenograft Model
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Triple-negative breast cancer; Electroacupuncture; Encircled needling;
   Tumor inhibition; Mechanisms
ID NECROSIS-FACTOR; ACUPUNCTURE; INFLAMMATION; PROSTATE; FATIGUE; DENSITY;
   BRAIN; ALPHA; CELLS; RISK
AB Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer without effective targeted drugs. While breast cancer patients often use acupuncture for the relief of cancer-induced pain or the side effects of chemo- or radiation therapy, little information is known regarding the direct effects of electroacupuncture on TNBC tumor and its potential mechanisms. Here, we created a mice model of TNBC and electroacupuncture with encircled needling around the tumors was given to the animals daily for 3 weeks at 15-20 Hz (3 min, each time). For sham electroacupuncture control, the skin was punctured to a depth of 5 mm and then the needle was quickly withdrawn without electrical stimulation or manual needle manipulation. We found that electroacupuncture significantly inhibited TNBC tumor growth and the inhibitory rate increased gradually overtime. Mechanistic analysis showed that electroacupuncture inhibited tumor angiogenesis by reducing the expression of vascular endothelial growth factor A (VEGF-A), its receptor VEGF-R and neuropilin 1 (NRP-1). Electroacupuncture also led to a significant decrease of matrix metalloproteinase-2 (MMP-2) expression and an increase of tissue inhibitor of MMP (TIMP-2) expression. Additionally, the expression of semaphorin 3A (Sema3A) and nerve growth factor receptor (NGFR) p75 in TNBC tissue was significantly upregulated in response to electroacupuncture. Furthermore, tumor necrosis factor (TNF)-alpha level in the serum was dramatically reduced after electroacupuncture. These results showed that electroacupuncture could directly inhibit TNBC tumor growth through the inhibition of proteins related to tumor angiogenesis and extracellular matrix, the suppression of TNBC-induced inflammation and the upregulation of nerve growth factor receptors.
C1 [Jiang, Xin; Tian, Yehong; Xu, Lin; Zhang, Qiaoli; Wan, Yuxiang; Qi, Xuewei; Huang, Jinchang] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing 100029, Peoples R China.
   [Jiang, Xin; Gu, Xiaohong] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Li, Bo] Capital Med Univ, Beijing Chest Hosp, Dept Tradit Chinese Med, Beijing 101149, Peoples R China.
   [Guo, Jing; Sun, Weiliang] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China.
   [Luo, Aiping] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, State Key Lab Mol Oncol,Natl Canc Ctr, Beijing 100021, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Capital Medical University; China-Japan Friendship Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Cancer Institute & Hospital - CAMS
RP Gu, XH (corresponding author), Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.; Huang, JC (corresponding author), Beijing Univ Chinese Med, Dept Acupuncture & Minimally Invas Oncol, Affiliated Hosp 3, Beijing 100029, Peoples R China.
EM C655@bucm.edu.cn; guxh1003@126.com
RI Li, Bo/AAA-8968-2020; Wan, Yuxiang/AAU-9771-2020; guo,
   jing/OKS-5559-2025; Gu, Xiaohong/AGY-1660-2022
OI Wan, Yuxiang/0000-0003-0778-551X; 
FU Beijing Municipal Natural Science Foundation [7172128]; National Natural
   Science Foundation for Young Scientists of China [81804177]
FX This study was supported by Beijing Municipal Natural Science Foundation
   (Grant no. 7172128) and the National Natural Science Foundation for
   Young Scientists of China (Grant no. 81804177).
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NR 46
TC 16
Z9 22
U1 7
U2 29
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2019
VL 16
IS 12
BP 1642
EP 1651
DI 10.7150/ijms.38521
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JO0TE
UT WOS:000497298800013
PM 31839752
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chan, KY
   Lui, L
   Yu, KL
   Lau, K
   Lai, MC
   Lau, W
   Ng, B
   Zhong, LLD
   Bian, ZX
AF Chan, Kaiyin
   Lui, Louisa
   Yu, Kaling
   Lau, Kwongwai
   Lai, Manchi
   Lau, Waiwai
   Ng, Bacon
   Zhong, Linda L. D.
   Bian, Zhao-Xiang
TI The efficacy and safety of electro-acupuncture for alleviating
   chemotherapy-induced peripheral neuropathy in patients with coloreactal
   cancer: study protocol for a single-blinded, randomized sham-controlled
   trial
SO TRIALS
LA English
DT Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Oxaliplatin;
   Colorectal cancer
ID QUALITY-OF-LIFE; ONCOLOGY; QUESTIONNAIRE; ACUPUNCTURE; PREVENTION;
   VALIDATION
AB Background Colorectal cancer is the most common cancer in Hong Kong. Oxaliplatin-based chemotherapy is a major first-line conventional therapy for advanced and metastatic colorectal cancer. However, oxaliplatin causes chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture has long been used to alleviate limb numbness in Chinese medicine. This study aims to examine the efficacy and safety of acupuncture for alleviating CIPN in patients with colorectal cancer in Hong Kong. Methods/design This is a single-blinded, randomized, sham-controlled efficacy trial. Eighty-four eligible patients, who are Hong Kong Chinese, aged >= 18 years, diagnosed with colorectal cancer and undergoing oxaliplatin-based chemotherapy, will be randomized in a ratio of 1:1 to the electro-acupuncture group or the sham-controlled group. During a 12-week treatment period, patients in the electro-acupuncture group will undergo electro-acupuncture once a week from the first cycle of chemotherapy, while patients in the control group will receive sham acupuncture, and the patients in both groups will be followed up for 12 weeks. The primary outcome measure is the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOC-Ntx) questionnaire. The secondary outcome measures include numerical rating scale (NRS) for numbness/pain, vibration and light touch sense test, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) and Constitution of Chinese Medicine Questionnaire (CCMQ). Discussion The study will compare electro-acupuncture with sham acupuncture to explore the feasibility for electro-acupuncture in improving symptoms caused by chemotherapy-induced peripheral neuropathy.
C1 [Chan, Kaiyin; Yu, Kaling; Lau, Kwongwai; Lai, Manchi; Lau, Waiwai] Hong Kong Baptist Univ, Yan Chai Hosp, Chinese Med Clin, Training & Res Ctr,Ha Kwai Chung, Hong Kong, Peoples R China.
   [Lui, Louisa] Princess Margaret Hosp, Oncol Dept, Kwai Chung, Hong Kong, Peoples R China.
   [Ng, Bacon] Hong Kong Hosp Author, Chinese Med Dept, Kowloon, Hong Kong, Peoples R China.
   [Zhong, Linda L. D.; Bian, Zhao-Xiang] Hong Kong Baptist Univ, Hong Kong Chinese Med Clin Study Ctr, Jockey Club Sch Chinese Bldg,7 Baptist Rd, Hong Kong, Peoples R China.
   [Zhong, Linda L. D.; Bian, Zhao-Xiang] Hong Kong Baptist Univ, Sch Chinese Med, Jockey Club Sch Chinese Bldg,7 Baptist Rd, Hong Kong, Peoples R China.
C3 Hong Kong Baptist University; Hong Kong Baptist University; Hong Kong
   Baptist University
RP Zhong, LLD; Bian, ZX (corresponding author), Hong Kong Baptist Univ, Hong Kong Chinese Med Clin Study Ctr, Jockey Club Sch Chinese Bldg,7 Baptist Rd, Hong Kong, Peoples R China.; Zhong, LLD; Bian, ZX (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Jockey Club Sch Chinese Bldg,7 Baptist Rd, Hong Kong, Peoples R China.
EM ldzhong@hkbu.edu.hk; bzxiang@hkbu.edu.hk
RI Ng, Bacon F L/I-5554-2013; Zhong, Linda/AAI-7376-2021
OI Ng, Bacon F L/0000-0003-1682-8382; Zhong, Linda/0000-0002-3877-1914
FU Hong Kong Hospital Authority Chinese Medicine Department Research
   Practical Training Program
FX This research was financially supported by Hong Kong Hospital Authority
   Chinese Medicine Department Research Practical Training Program. The
   Hospital Authority Chinese Medicine Department provide training in the
   research technique and monitor the progress of study.
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NR 24
TC 11
Z9 13
U1 2
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 9
PY 2020
VL 21
IS 1
AR 58
DI 10.1186/s13063-019-3972-5
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KN2DB
UT WOS:000514650400005
PM 31918748
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Enblom, A
AF Enblom, Anna
TI Patients' and physiotherapists' belief in and use of acupuncture for
   cancer-related symptoms
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID CHEMOTHERAPY-INDUCED NAUSEA; ACUSTIMULATION WRIST BANDS; BREAST-CANCER;
   CONTROLLED-TRIAL; HOT FLASHES; ACUPRESSURE; PAIN; PREVENTION;
   ELECTROACUPUNCTURE; MULTICENTER
AB Background It is important to investigate attitudes to acupuncture, because therapists' and patients' expectations may affect the treatment outcome. Aim To explore the use of and belief in acupuncture among oncological physiotherapists and to explore patients' interest in receiving acupuncture during cancer therapy and their belief in its effectiveness.
   Methods 522 patients (80% female, mean age 67 years) reported on their interest in receiving acupuncture for nausea during radiotherapy treatment; a subgroup (n=198) additionally disclosed their belief in the effectiveness of acupuncture. 117 Swedish oncological physiotherapists (96% female, mean age 48 years) answered a questionnaire regarding their use of and belief in acupuncture.
   Results Of the patients initiating cancer therapy, 359 (69%) were interested in receiving acupuncture. The patients believed acupuncture to be effective for pain (79%), nausea (79%) and vasomotor symptoms (48%). Of the 117 physiotherapists, 66 (56%) practised acupuncture. Physiotherapists generally believed in the effectiveness of acupuncture. For pain, 89% believed that acupuncture was effective and 42% of them practised it. Similar responses were noted for chemotherapy-induced nausea (86% and 38%, respectively) and vasomotor symptoms (80% and 28%, respectively). Younger physiotherapists and patients were more likely to believe in the effectiveness of acupuncture compared with older ones.
   Conclusions More than two thirds of patients with cancer were interested in receiving acupuncture during therapy. Patients and oncological physiotherapists believed that acupuncture was effective for cancer pain, nausea and vasomotor symptoms. Further studies of acupuncture for cancer-related symptoms and of the effect of patients' and clinicians' therapeutic relationships, including treatment expectations, would be welcome.
C1 [Enblom, Anna] Linkoping Univ, Div Physiotherapy, Dept Med & Hlth Sci, Linkoping, Sweden.
C3 Linkoping University
RP Enblom, A (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
EM anna.enblom@liu.se
FU Linkoping University; region of Ostergotland; Osher Center for
   Integrative Medicine, Karolinska Institute, Sweden
FX The study was funded by Linkoping University, the region of Ostergotland
   and the Osher Center for Integrative Medicine, Karolinska Institute,
   Sweden.
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NR 40
TC 19
Z9 20
U1 0
U2 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD AUG
PY 2017
VL 35
IS 4
BP 251
EP 258
DI 10.1136/acupmed-2015-011007
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FE0JF
UT WOS:000407905900002
PM 28442462
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Liou, KT
   Baser, RE
   Bao, T
   Panageas, KS
   Romero, SAD
   Li, QS
   Gallagher, RM
   Kantoff, PW
AF Mao, Jun J.
   Liou, Kevin T.
   Baser, Raymond E.
   Bao, Ting
   Panageas, Katherine S.
   Romero, Sally A. D.
   Li, Q. Susan
   Gallagher, Rollin M.
   Kantoff, Philip W.
TI Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual
   Care for Chronic Musculoskeletal Pain Among Cancer Survivors The PEACE
   Randomized Clinical Trial
SO JAMA ONCOLOGY
LA English
DT Article
ID UNITED-STATES; OUTCOMES; MECHANISMS; SCORES; IMPACT
AB IMPORTANCE The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain.
   OBJECTIVE To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors.
   DESIGN, SETTING, AND PARTICIPANTS The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial is a randomized clinical trial that was conducted from March 2017 to October 2019 (follow-up completed April 2020) across an urban academic cancer center and 5 suburban sites in New York and New Jersey. Study statisticians were blinded to treatment assignments. The 360 adults included in the study had a prior cancer diagnosis but no current evidence of disease, reported musculoskeletal pain for at least 3 months, and self-reported pain intensity on the Brief Pain Inventory (BPI) ranging from 0 (no pain) to 10 (worst pain imaginable).
   INTERVENTIONS Patients were randomized 2:2:1 to electroacupuncture (n = 145), auricular acupuncture (n = 143), or usual care (n = 72). Intervention groups received 10 weekly sessions of electroacupuncture or auricular acupuncture. Ten acupuncture sessions were offered to the usual care group from weeks 12 through 24.
   MAIN OUTCOMES AND MEASURES The primary outcomewas change in average pain severity score on the BPI from baseline to week 12. Using a gatekeeping multiple-comparison procedure, electroacupuncture and auricular acupuncture were compared with usual care using a linear mixed model. Noninferiority of auricular acupuncture to electroacupuncture was tested if both interventions were superior to usual care.
   RESULTS Among 360 cancer survivors (mean [SD] age, 62.1 [12.7] years; mean [SD] baseline BPI score, 5.2 [1.7] points; 251 [69.7%] women; and 88 [24.4%] non-White), 340 (94.4%) completed the primary end point. Compared with usual care, electroacupuncture reduced pain severity by 1.9 points (97.5% CI, 1.4-2.4 points; P <.001) and auricular acupuncture reduced by 1.6 points (97.5% CI, 1.0-2.1 points; P <.001) from baseline to week 12. Noninferiority of auricular acupuncture to electroacupuncture was not demonstrated. Adverse events were mild; 15 of 143 (10.5%) patients receiving auricular acupuncture and 1 of 145 (0.7%) patients receiving electroacupuncture discontinued treatments due to adverse events (P <.001).
   CONCLUSIONS AND RELEVANCE In this randomized clinical trial among cancer survivors with chronic musculoskeletal pain, electroacupuncture and auricular acupuncture produced greater pain reduction than usual care. However, auricular acupuncture did not demonstrate noninferiority to electroacupuncture, and patients receiving it had more adverse events.
C1 [Mao, Jun J.; Liou, Kevin T.; Bao, Ting; Li, Q. Susan] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
   [Baser, Raymond E.; Panageas, Katherine S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
   [Romero, Sally A. D.] Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Kantoff, Philip W.] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
   [Gallagher, Rollin M.] Michael J Crescenz VA Med Ctr, Ctr Hlth Equity Res & Promot, Philadelphia, PA USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; University of California System; University of California San
   Diego; Memorial Sloan Kettering Cancer Center; University of
   Pennsylvania
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
FU Department of Defense office of the Congressionally Directed Medical
   Research Programs through the Peer Reviewed Medical Research Program
   Clinical Trial Award [W81XWH-15-1-0245]; National Institutes of
   Health/National Cancer Institute Cancer Center grant [P30 CA008748]
FX This work was supported by the Department of Defense office of the
   Congressionally Directed Medical Research Programs through the Peer
   Reviewed Medical Research Program Clinical Trial Award
   (W81XWH-15-1-0245). This work was also supported in part by a National
   Institutes of Health/National Cancer Institute Cancer Center grant (P30
   CA008748).
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NR 29
TC 149
Z9 177
U1 13
U2 140
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2374-2437
EI 2374-2445
J9 JAMA ONCOL
JI JAMA Oncol.
PD MAY
PY 2021
VL 7
IS 5
BP 720
EP 727
DI 10.1001/jamaoncol.2021.0310
EA MAR 2021
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SF3PH
UT WOS:000630524200002
PM 33734288
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Cheon, S
   Lee, H
AF Cheon, Soyeon
   Lee, Hyangsook
TI Correspondence regarding Anshasi and Ahmad's "an assessment of
   methodological quality of systematic reviews of acupuncture and related
   therapies for cancer-related pain" in complement ther clin pract 2018
   August
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Letter
DE Pharmacopuncture; Acupoint injection; Acupuncture; Cancer
C1 [Cheon, Soyeon; Lee, Hyangsook] Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, Kyung Hee Dae Ro 26, Seoul 02447, South Korea.
   [Cheon, Soyeon] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70101, Taiwan.
C3 Kyung Hee University; National Cheng Kung University
RP Lee, H (corresponding author), Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, Kyung Hee Dae Ro 26, Seoul 02447, South Korea.
EM erc633@khu.ac.kr
RI LEE, HYANGSOOK/D-2070-2017
OI LEE, HYANGSOOK/0000-0002-1107-9389; Cheon, Soyeon/0000-0003-2838-3720
CR Anshasi HA, 2018, COMPLEMENT THER CLIN, V32, P163, DOI 10.1016/j.ctcp.2018.06.013
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NR 4
TC 1
Z9 1
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD NOV
PY 2018
VL 33
BP 138
EP 138
DI 10.1016/j.ctcp.2018.09.008
PG 1
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GZ2GW
UT WOS:000449198200019
PM 30396611
DA 2026-01-16
ER

PT J
AU Running, A
   Turnbeaugh, E
AF Running, Alice
   Turnbeaugh, Elizabeth
TI Oncology Pain and Complementary Therapy: A Review of the Literature
SO CLINICAL JOURNAL OF ONCOLOGY NURSING
LA English
DT Review
ID CANCER PAIN; MASSAGE THERAPY; NEUROPATHIC PAIN; BONE PAIN; MEDICINE;
   ANXIETY; ELECTROACUPUNCTURE; INTERVENTION; ACUPUNCTURE; RELAXATION
AB Half of all patients with cancer experience some level of pain, so pain management is an important topic for oncology nurses. Pharmacologic measures traditionally are the primary intervention for bone, visceral, neuropathic, and procedural pain; however, many patients are turning to an integrative approach of Western and complementary therapies for pain and symptom management. The authors explored the current evidence concerning the effectiveness of complementary therapies in relation to cancer pain and symptom control.
C1 [Running, Alice] Univ Nevada, Orvis Sch Nursing, Div Hlth Sci, Reno, NV 89557 USA.
   [Turnbeaugh, Elizabeth] St Marys Heil Rd Clin, Reno, NV USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Reno
RP Running, A (corresponding author), Univ Nevada, Orvis Sch Nursing, Div Hlth Sci, Reno, NV 89557 USA.
EM running@unr.edu
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NR 41
TC 12
Z9 16
U1 0
U2 23
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 1092-1095
EI 1538-067X
J9 CLIN J ONCOL NURS
JI Clin. J. Oncol. Nurs.
PD AUG
PY 2011
VL 15
IS 4
BP 374
EP 379
DI 10.1188/11.CJON.374-379
PG 6
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA 805KD
UT WOS:000293724400007
PM 21810570
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Xie, SR
   Farrar, JT
   Stricker, CT
   Bowman, M
   Bruner, D
   DeMichele, A
AF Mao, Jun J.
   Xie, Sharon
   Farrar, John T.
   Stricker, Carrie Tompkins
   Bowman, Marjorie
   Bruner, Deborah
   DeMichele, Angela
TI Electro-acupuncture for joint pain related to aromatase inhibitors among
   breast cancer survivors: A randomized placebo-controlled trial.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 31-JUN 04, 2013
CL Chicago, IL
SP Amer Soc Clin Oncol
C1 Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
   Wright State Univ, Sch Med, Dayton, OH USA.
   Emory Univ, Neil Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
C3 University of Pennsylvania; University of Pennsylvania; University
   System of Ohio; Wright State University Dayton; Emory University
RI bowman, marjorie/F-7235-2013; Xie, Sharon/JCO-7144-2023; Farrar,
   John/AAP-4788-2021
NR 0
TC 0
Z9 0
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2013
VL 31
IS 15
SU S
MA 9639
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA AG4VY
UT WOS:000335419603122
DA 2026-01-16
ER

PT J
AU Hou, YC
   Lu, JJ
   Xie, J
   Zhu, RJ
   Wu, MD
   Wang, K
   Zhou, J
   Li, J
AF Hou, Yuchao
   Lu, Jiajing
   Xie, Jing
   Zhu, Runjia
   Wu, Mengdie
   Wang, Ke
   Zhou, Jia
   Li, Jing
TI Effects of electroacupuncture on perioperative anxiety and stress
   response in patients undergoing surgery for gastric or colorectal
   cancer: Study protocol for a randomized controlled trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE perioperative anxiety; stress response; electroacupuncture; surgery;
   randomized controlled clinical trial (RCT)
ID PREOPERATIVE ANXIETY; ENHANCED RECOVERY; GASTROINTESTINAL SURGERY; STATE
   ANXIETY; YINTANG POINT; SHORT-FORM; ACUPUNCTURE; SCALE; ACUPRESSURE;
   ANALGESIA
AB Background Perioperative anxiety is one of the main psychological stresses experienced by patients who undergo cancer surgery. The surgery itself inevitably causes a stress response characterized by activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. Both the perioperative anxiety and surgical stress response lead to increased levels of catecholamines and prostaglandins, which may be related to perioperative suppression of antimetastatic immunity and tumor-promoting alterations in the microenvironment. Hence, we designed this clinical trial to investigate the effect of electroacupuncture in reducing perioperative anxiety and surgical stress response.Methods This is a randomized, single-center, parallel, and controlled clinical trial. Seventy-eight participants between the ages of 35 and 85 with gastric or colorectal cancer who plan to undergo tumorectomy will be randomly divided into an electroacupuncture group and a control group. The primary outcome will be the six-item short form of the State-Trait Anxiety Inventory score. The secondary outcomes will be the Amsterdam Preoperative Anxiety and Information Scale score; levels of plasma cortisol, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha; first exhaust time after surgery; postoperative quality of the recovery-15 score, numeric rating scale for pain score; and dosage of postoperative analgesics.Discussion Cumulative studies revealed the efficacy of various types of acupuncture therapy with regard to reducing the anxiety and stress response caused by surgery. We expect that the results of this trial will provide high-quality clinical evidence for the choice of perioperative acupuncture for patients undergoing cancer surgery.
C1 [Hou, Yuchao; Lu, Jiajing; Xie, Jing; Zhu, Runjia; Wu, Mengdie; Wang, Ke; Zhou, Jia; Li, Jing] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhou, J; Li, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Shanghai, Peoples R China.
EM pdzhoujia@163.com; lj0806@hotmail.com
RI Wang, Ke/JXN-9969-2024
FU BEBPC-TCM [2019XZZX-ZJ0011]; Accelerating the Development of Chinese
   Medicine Three-Year Action Plan of Shanghai
   [ZY(2018-2020)-CCCX-2004-04]; Clinical Key Specialty Construction
   Foundation of Shanghai [shslczdzk04701]; Shanghai Clinical Research
   Center for Acupuncture and Moxibustion [20MC1920500]; Three-year Action
   Plan of Shanghai Municipality to Further Accelerate the Inheritance,
   Innovation and Development of Traditional Chinese Medicine
   [ZY(2021-2023)-0302]
FX This work was supported by the BEBPC-TCM (No. 2019XZZX-ZJ0011),
   Accelerating the Development of Chinese Medicine Three-Year Action Plan
   of Shanghai [No. ZY(2018-2020)-CCCX-2004-04], Clinical Key Specialty
   Construction Foundation of Shanghai (No. shslczdzk04701), and Shanghai
   Clinical Research Center for Acupuncture and Moxibustion (No.
   20MC1920500). Three-year Action Plan of Shanghai Municipality to Further
   Accelerate the Inheritance, Innovation and Development of Traditional
   Chinese Medicine [ZY(2021-2023)-0302].
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NR 49
TC 9
Z9 11
U1 2
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 23
PY 2023
VL 14
AR 1095650
DI 10.3389/fpsyt.2023.1095650
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 9S2ZL
UT WOS:000946214500001
PM 36911113
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Henry, NL
   Kidwell, KM
   Kozar, S
   Snyder, S
   Zick, SM
AF Henry, N. Lynn
   Kidwell, Kelley M.
   Kozar, Stephanie
   Snyder, Sara
   Zick, Suzanna M.
TI Self-acupressure for patients with breast cancer experiencing aromatase
   inhibitor-associated musculoskeletal symptoms: Protocol for the AcuAIM
   randomized pilot trial
SO PLOS ONE
LA English
DT Article
ID ACUPUNCTURE; PAIN; OUTCOMES; THERAPY; FATIGUE; WOMEN; DISCONTINUATION;
   MULTICENTER; SURVIVORS
AB Background
   Aromatase inhibitors (AI) reduce hormone receptor-positive breast cancer recurrence risk by about 50%. However, half of AI-treated postmenopausal women report new or worsened musculoskeletal symptoms (AIMSS), and 20% discontinue therapy prematurely. Acupuncture is effective for reducing symptoms, but many women are not able to access acupuncture therapy. We hypothesize that self-administered acupressure will reduce AIMSS.
   Materials and methods
   Postmenopausal women who have been receiving treatment with an AI for more than 3 weeks but less than 2 years, and who report new or worsened joint pain or myalgias since starting AI therapy with worst pain of at least 4 out of 10 on a numerical rating scale, are eligible. Fifty participants will be enrolled and randomized 1:1 to treatment with true or sham acupressure for 12 weeks. Participants will self-apply pressure for 3 minutes to each of the 9 acupoints daily. All participants will complete a pain assessment weekly, and a battery of symptom questionnaires every 6 weeks. Optional stool samples will be collected after 0 and 12 weeks of acupressure to examine changes in the gut microbiome. The primary endpoint is change in worst pain on the Brief Pain Inventory-Short Form with 12 weeks of the acupressure intervention, evaluated with generalized estimating equations.
   Conclusion
   Determination that self-administered acupressure reduces AIMSS in this randomized phase 2 pilot trial will lead to a larger randomized phase 3 clinical trial to confirm the efficacy of self-acupressure. Reduction of AI-related arthralgias may improve persistence with breast cancer therapy, breast cancer outcomes, and quality of life for AI-treated patients.
C1 [Henry, N. Lynn; Kozar, Stephanie; Snyder, Sara; Zick, Suzanna M.] Univ Michigan, Med Sch, Ann Arbor, MI 48109 USA.
   [Henry, N. Lynn; Kidwell, Kelley M.; Zick, Suzanna M.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Henry, NL (corresponding author), Univ Michigan, Med Sch, Ann Arbor, MI 48109 USA.
EM norahh@med.umich.edu
OI Zick, Suzanna/0000-0003-0914-4927; Henry, N Lynn/0000-0002-4771-5930
FU Breast Cancer Research Foundation [23-206]
FX The trial is funded by the Breast Cancer Research Foundation (NLH, SMZ;
   grant number 23-206; bcrf.org). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 42
TC 1
Z9 1
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 22
PY 2025
VL 20
IS 1
AR e0311044
DI 10.1371/journal.pone.0311044
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2VJ3V
UT WOS:001492214200010
PM 39841658
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, SS
   Wang, B
   Wang, JQ
   Guo, Y
   Li, SS
   Zhao, SH
   Yang, YZ
   Feng, YT
   Xu, ZF
AF Lu, Shanshan
   Wang, Bin
   Wang, Jiaqi
   Guo, Yi
   Li, Shanshan
   Zhao, Suhong
   Yang, Yuanzhen
   Feng, Yiting
   Xu, Zhifang
TI Moxibustion for the Treatment of Cancer and its Complications:
   Efficacies and Mechanisms
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE moxibustion; cancer; complications of cancer; chemotherapy; side-effect
ID NATURAL-KILLER-CELLS; QUALITY-OF-LIFE; METASTATIC CANCER; LYMPHOCYTE
   RATIO; BREAST-CANCER; GROWTH-FACTOR; LUNG-CANCER; FATIGUE; CHEMOTHERAPY;
   HYPERTHERMIA
AB Cancer treatment remains a significant challenge for the medical community, and improved therapies are necessary to treat cancer and its associated complications. Current anticancer therapies often have significant side effects, underscoring the need for new treatment options. Moxibustion is a representative external therapy used in traditional Chinese medicine. This review examines clinical studies demonstrating moxibustion's ability to improve the efficacy of radiotherapy and chemotherapy and control tumor progression. Moxibustion can prevent and treat various complications of cancer, including cancer-related or therapy-induced gastrointestinal symptoms, myelosuppression, fatigue, pain, and postoperative lymphedema. has also been shown to enhance the quality of life for cancer patients. However, very few studies have investigated the underlying mechanisms for these effects, a topic that requires systematic elucidation. Evidence has shown that moxibustion alone or combined with chemotherapy can improve survival and inhibit tumor growth in cancer-bearing animal models. The anticancer effect of moxibustion is associated with alleviating the tumor immunosuppressive and vascular microenvironments. Additionally, the therapeutic effects of moxibustion may originate from the heat and radiation produced during the combustion process on acupoints or lesions. This evidence provides a scientific basis for the clinical application of moxibustion in anticancer treatment and reducing the side effects of cancer therapies and helps promote the precise application of moxibustion in cancer treatment.
C1 [Lu, Shanshan; Wang, Bin] Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjin, Peoples R China.
   [Lu, Shanshan; Wang, Jiaqi; Guo, Yi; Li, Shanshan; Zhao, Suhong; Yang, Yuanzhen; Feng, Yiting; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
   [Guo, Yi; Xu, Zhifang] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China.
   [Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
   [Wang, Jiaqi] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
C3 Tianjin Medical University; Tianjin University of Traditional Chinese
   Medicine; Tianjin University of Traditional Chinese Medicine; Tianjin
   University of Traditional Chinese Medicine
RP Xu, ZF (corresponding author), Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.; Wang, JQ (corresponding author), Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
EM wangjiaqi557@163.com; xuzhifangmsn@hotmail.com
RI Feng, YiTing/KIH-6419-2024; guo, yi/KHC-4669-2024
FU Tianjin Innovation and Entrepreneurship Training Plan for College
   Students [202210063035]; National Innovation and Entrepreneurship
   Training Plan for College Students [20210063010]; National Natural
   Science Foundation of China (NSFC) [82074534]; Research Project of
   Tianjin Municipal Health Commission on Traditional Chinese Medicine and
   Integrative Medicine [2019140]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by Tianjin Innovation and Entrepreneurship Training Plan
   for College Students (No. 202210063035). National Innovation and
   Entrepreneurship Training Plan for College Students (No. 20210063010),
   the National Natural Science Foundation of China (NSFC) (No. 82074534).
   Research Project of Tianjin Municipal Health Commission on Traditional
   Chinese Medicine and Integrative Medicine (No. 2019140).
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NR 110
TC 23
Z9 24
U1 9
U2 39
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231198089
DI 10.1177/15347354231198089
PG 18
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA S3SU5
UT WOS:001070409400001
PM 37746720
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, SQ
   Wu, TT
   Zhang, HH
   Yang, Y
   Jiang, HY
   Cao, SC
   Xie, F
   Xia, XT
   Lu, JQ
   Zhong, Y
AF Zhang Shiqiang
   Wu Tingting
   Zhang Haisheng
   Yang Yun
   Jiang Haiyan
   Cao Shengcheng
   Xie Fang
   Xia Xiaoting
   Lu Junqiang
   Zhong Yi
TI Effect of electroacupuncture on chemotherapy-induced peripheral
   neuropathy in patients with malignant tumor: a single-blinded,
   randomized controlled trial
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Electroacupuncture; Quality of life; Chemotherapy-induced peripheral
   neuropathy; Randomized controlled trial
ID ACUPUNCTURE; CANCER; PAIN
AB OBJECTIVE: To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy (CIPN), quality of life and immune status of patients with malignant tumors.
   METHODS: From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy. The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment. Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment. Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.
   RESULTS: The gender, age, cancer species as well as incidence (83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture (all P > 0.05). After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture (84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture (83.3% vs 72.2%). Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment (x(2) = 9.745, P = 0.002). The grades of peripheral neuropathy were significantly different in the two groups post-treatment (x(2) = 13.983, P = 0.007). The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively (Z = - 4.239, P < 0.001). The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture (Z = - 4.76, P < 0.001). Both electroacupuncture and acupuncture had no effects on immune function.
   CONCLUSION: Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. (C) 2017 JTCM. All rights reserved.
C1 [Zhang Shiqiang; Wu Tingting; Yang Yun; Jiang Haiyan; Xia Xiaoting; Lu Junqiang; Zhong Yi] Shanghai Univ Tradit Chinese Med, Shanghai Tradit Chinese Med Integrated Hosp, Oncol Dept, Shanghai 200082, Peoples R China.
   [Zhang Haisheng; Cao Shengcheng] Fangta Tradit Chinese Med Hosp of Songjiang Dist, Oncol Dept, Shanghai 201600, Peoples R China.
   [Xie Fang] Jingan Dist Ctr Hosp Shanghai, Oncol Dept, Shanghai 200040, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhong, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Tradit Chinese Med Integrated Hosp, Oncol Dept, Shanghai 200082, Peoples R China.
EM zhyimed@163.com
RI Zhong, Yi/JQI-5739-2023; Lu, Junqiang/LTZ-9866-2024
FU Comprehensive and Integrative Medicine Institute, Korea; Shanghai
   TCM-integrated Hospital; Effect of Bushen-Jianpi Decoction on
   Postoperative Recurrence and Vasculogenic Mimicry Formation after
   Recurrence in Liver Cancer Tissues of Nude Mice with Transplanted Liver
   Cancer [2012J003A]; Mechanism Study of Fuzheng Jianpi Decoction on Tumor
   Metastasis Inhibition by Protecting Intestinal Barrier and Regulating
   PI3K/AKT Signaling Pathway Expression in Colorectal Tumor
   Microenvironment [15ZR1438700]; Effect of Jianpi-Guchang Decoction on
   the Gut Barrier Function and Immune Function in Lung or Colorectal
   Cancer Patients Treated by Chemotherapy Based on the Thought of "Same
   Treatment for Different Diseases" [15401930300]; Effect of Jianpi-Guben
   Decoction on the Gut Barrier Function in Postoperative Colorectal Cancer
   Patients Treated by Chemotherapy to Balance the Gut Enviroment [Hongkou
   1502-01]
FX Supported by the Study of Electric Acupuncture in Preventing the
   Peripheral Neuritis Induced by Chemotherapy and Promoting the Immune
   Function in Cancer Patients from: Comprehensive and Integrative Medicine
   Institute, Korea; Mechanism Study of Electric Acupuncture in
   Oxaliplatin-chemotherapy-induced Peripheral Neuropathy by SP-NM-DAR
   Pathway from: Shanghai TCM-integrated Hospital; Effect of Bushen-Jianpi
   Decoction on Postoperative Recurrence and Vasculogenic Mimicry Formation
   after Recurrence in Liver Cancer Tissues of Nude Mice with Transplanted
   Liver Cancer (No. 2012J003A); Mechanism Study of Fuzheng Jianpi
   Decoction on Tumor Metastasis Inhibition by Protecting Intestinal
   Barrier and Regulating PI3K/AKT Signaling Pathway Expression in
   Colorectal Tumor Microenvironment (No. 15ZR1438700); Effect of
   Jianpi-Guchang Decoction on the Gut Barrier Function and Immune Function
   in Lung or Colorectal Cancer Patients Treated by Chemotherapy Based on
   the Thought of "Same Treatment for Different Diseases" (No.
   15401930300); Effect of Jianpi-Guben Decoction on the Gut Barrier
   Function in Postoperative Colorectal Cancer Patients Treated by
   Chemotherapy to Balance the Gut Enviroment (No. Hongkou 1502-01)
CR [Anonymous], CANCER
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NR 21
TC 19
Z9 19
U1 0
U2 32
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD APR
PY 2017
VL 37
IS 2
BP 179
EP 184
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EU7HS
UT WOS:000401206500005
PM 29960289
DA 2026-01-16
ER

PT J
AU Lin, TY
   Hsieh, CL
AF Lin, Ting-Yen
   Hsieh, Ching-Liang
TI Clinical Applications of Bee Venom Acupoint Injection
SO TOXINS
LA English
DT Review
DE bee venom; acupoint injections; clinical application; pharmacological
   mechanism
ID SPINAL-CORD-INJURY; ACUPUNCTURE POINT; NEUROPATHIC PAIN;
   RHEUMATOID-ARTHRITIS; MECHANICAL ALLODYNIA; REPETITIVE TREATMENT;
   FUNCTIONAL RECOVERY; PARKINSONS-DISEASE; FOS EXPRESSION; SHOULDER PAIN
AB Bee venom is a complex natural mixture with various pharmaceutical properties. Among these properties, its peptides and enzymes have potential medical therapy for pain relief and inflammation. In clinical settings, this therapy has been used widely to treat diseases by injecting into acupoints. In this article, we have conducted various research from PubMed, Cochrane Library, and Clinical Key from inception of July 2020. The results revealed that bee venom therapy has been reported effective in anti-inflammatory, antiapoptosis, and analgesic effects. Moreover, bee venom acupuncture has been commonly used for clinical disorders such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple sclerosis, skin disease and cancer.
C1 [Lin, Ting-Yen; Hsieh, Ching-Liang] China Med Univ Hosp, Dept Chinese Med, Taichung 40447, Taiwan.
   [Hsieh, Ching-Liang] China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 40402, Taiwan.
   [Hsieh, Ching-Liang] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University Taiwan
RP Hsieh, CL (corresponding author), China Med Univ Hosp, Dept Chinese Med, Taichung 40447, Taiwan.; Hsieh, CL (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung 40402, Taiwan.; Hsieh, CL (corresponding author), China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
EM u103030067@cmu.edu.tw; clhsieh@mail.cmuh.org.tw
FU Chinese Medicine Research Center of China Medical University; Featured
   Areas Research Center Program within the framework of the Taiwan
   Ministry of Education Higher Education Sprout Project [CMRC-CENTER-0]
FX This work was financially supported by the Chinese Medicine Research
   Center of China Medical University with the assistance of the Featured
   Areas Research Center Program within the framework of the Taiwan
   Ministry of Education Higher Education Sprout Project (CMRC-CENTER-0).
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NR 108
TC 35
Z9 39
U1 4
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD OCT
PY 2020
VL 12
IS 10
AR 618
DI 10.3390/toxins12100618
PG 25
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA OM8ZN
UT WOS:000586305400001
PM 32992601
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Han, G
   Lee, YS
   Jang, HJ
   Kim, SY
   Lee, YJ
   Ha, IH
AF Han, Gajin
   Lee, Ye-Seul
   Jang, Hee Jae
   Kim, Song-Yi
   Lee, Yoon Jae
   Ha, In-Hyuk
TI Symptom Management and Quality of Life of Breast Cancer Patients Using
   Acupuncture-Related Therapies and Herbal Medicine: A Scoping Review
SO CANCERS
LA English
DT Review
DE breast cancer; anticancer treatment; side effects; acupuncture; herbal
   medicine; scoping review
ID INDUCED PERIPHERAL NEUROPATHY; POSTMASTECTOMY PAIN SYNDROME;
   CONTROLLED-TRIAL; FOLLOW-UP; WOMEN; FATIGUE; ELECTROACUPUNCTURE;
   COMPLEMENTARY; ARTHRALGIA; LYMPHEDEMA
AB Simple Summary This is a scoping review of published literature on the usefulness of acupuncture-related therapies and herbal medicine in alleviating the side effects associated with breast cancer treatments. It is an important study given that the various treatment interventions for breast cancer, such as surgery, chemotherapy, radiotherapy, and hormone therapy, have unpleasant side effects that compromise the patient's quality of life. The study revealed positive impact of some acupuncture-related therapies and herbal medicines in improving the symptoms and quality of life of patients with breast cancer. These findings will inform further studies on the economic impact of acupuncture and herbal medicines in the management of adverse events in patients on breast cancer treatment. The side effects associated with breast cancer treatments often reduce the patients' quality of life. The effectiveness of acupuncture-related therapies and herbal medicine in managing the side effect is not fully understood. The study included clinical studies published in the 10 years since 2011 and analyzed the effectiveness of the therapies for managing side effects of anticancer treatment. The databases of MEDLINE via PubMed, CENTRAL, EMBASE, OASIS, and NSDL were searched. Thirty studies, including 13 (43.3%) randomized controlled trials (RCTs), 12 (40.0%) before-and-after studies, three (10.0%) case series, one (3.3%) case report, and one (3.3%) non-RCT, were included in this review. The main symptoms identified were aromatase inhibitors-induced arthralgia (AIA), lymphedema, and chemotherapy-induced peripheral neuropathy (CIPN). The types of acupuncture-related therapies applied included manual acupuncture, electro-acupuncture, moxibustion, and electro-moxibustion. In ten studies, eight herbal medications were administered. The Brief Pain Inventory-Short Form (BPI-SF) and Functional Assessment of Cancer Therapy-General (FACT-G) and -Breast (FACT-B) were frequently used to evaluate pain and QoL, respectively. Most studies suggested beneficial effects of acupuncture and herbal medicine on managing pain, daily function, and quality of life in patients going through AIA, CIPN, and/or lymphedema, with mild side effects. The scoping review implies the potential of CAM therapies as promising interventions for managing symptoms which otherwise lack alternative management options, and for improving the quality of life of breast cancer patients.
C1 [Han, Gajin] JINRESEARCH, Namyangju 12113, South Korea.
   [Han, Gajin] Kyung Hee Sweet & Sunny Korean Med Clin, Namyangju 12113, South Korea.
   [Lee, Ye-Seul; Lee, Yoon Jae; Ha, In-Hyuk] Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul 06110, South Korea.
   [Jang, Hee Jae] Kyung Hee Yakson Korean Med Clin, Suwon 16393, South Korea.
   [Kim, Song-Yi] Gachon Univ, Coll Korean Med, Dept Anat & Acupoint, Seongnam 13120, South Korea.
C3 Gachon University
RP Lee, YS (corresponding author), Jaseng Med Fdn, Jaseng Spine & Joint Res Inst, Seoul 06110, South Korea.
EM yeseul.j.lee@gmail.com
RI Lee, Ye-Seul/HOC-2462-2023; Lee, Yoon Jae/ABA-8808-2020
OI Lee, Ye-Seul/0000-0001-6127-5401; Lee, Yoon Jae/0000-0002-1532-0942;
   Han, Gajin/0000-0003-2106-652X; HA, IN-HYUK/0000-0002-5020-6723; Kim,
   Song-Yi/0000-0002-3512-2134
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HF20C0222]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea
   (grant number: HF20C0222, Recipient: Y.-S.L.).
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NR 62
TC 13
Z9 16
U1 2
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD OCT
PY 2022
VL 14
IS 19
AR 4683
DI 10.3390/cancers14194683
PG 29
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5G3PJ
UT WOS:000866914000001
PM 36230606
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, Y
   Zhang, HL
   Xia, LP
   Sun, ZL
   Xu, X
   Du, SZ
AF Wang Yang
   Zhang Huiling
   Xia Liping
   Sun Zhiling
   Xu Xiao
   Du Shizheng
TI Effectiveness and safety of moxibustion in treatment of lumbar disc
   herniation: a systematic review and Meta-analysis
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Review
DE Moxibustion; Intervertebral disc displacement; Review; Meta-analysis;
   Randomized controlled trial
ID CANCER-RELATED FATIGUE; PAIN; ACUPUNCTURE; OUTCOMES
AB OBJECTIVE: To evaluate the effectiveness and safety of moxibustion therapy in the treatment of lumbar disc herniation (LDH).
   METHODS: Four Chinese databases and three English databases were searched from their inception to April 2018.Randomized controlled trials (RCTs) were included if moxibustion was used as the sole treatment or as a part of combination therapy with other treatments in patients with LDH. Two reviewers independently extracted the data and assessed the methodological quality using the Cochrane cri-teria for the risk of bias. The Meta-analysis was performed using Review Manager 5.3 software.
   RESULTS: In total, 16 RCTs including 1186 patients with LDH were analyzed. The Meta-analysis showed favorable effects of moxibustion in combination with massage therapy on the visual analog scale score compared with massage therapy alone [mean difference (MD) = -1.32, 95% confidence interval (CI) (-2.12, -0.51), P = 0.001]. The subgroup Meta-analysis failed to show favorable effects of electro-acupuncture plus moxibustion on the efficacy rate compared with electro-acupuncture alone [relative risk (RR) = 1.06, 95% CI (0.98, 1.14), P = 0.15]. However, acupuncture or massage therapy plus moxibustion improved the efficacy rates compared with acupuncture or massage therapy alone [RR = 1.33, 95% CI (1.18, 1.49), P < 0.000 01] [chi(2) = 2.76, P = 0.25, I-2 = 27%], [RR = 1.15, 95% CI (1.06, 1.25), P = 0.001] [chi(2) = 0.00, P = 0.95, I-2 = 0%]. With respect to the Japanese Orthopaedic Association (JOA) scores, acupuncture or massage therapy in addition to moxibustion produced results different from those of acupuncture or massage therapy alone [MD = 5.58, 95% CI (4.15, 7.00), P < 0.000 01] [chi(2) = 0.58, P = 0.45, I-2 = 0%], [MD = 3.61, 95% CI (3.01, 4.21), P < 0.000 01]. There were no significant differences in the JOA score for subjective symptoms, objective symptoms, daily living ability, and other parameters. In six RCTs, no adverse reactions occurred during moxibustion.
   CONCLUSION: Whether moxibustion is an effective intervention for LDH is unclear because of the small sample size of qualified RCTs and the high risk of bias. More high-quality RCTs that overcome the methodological shortcomings of the existing evidence are needed. (C) 2019 JTCM. All rights reserved.
C1 [Wang Yang; Xia Liping] Jiangsu Vocat Coll Med, Nursing Coll, Yancheng 224006, Peoples R China.
   [Zhang Huiling] Anhui Univ Chinese Med, Nursing Coll, Hefei 230012, Anhui, Peoples R China.
   [Sun Zhiling; Du Shizheng] Nanjing Univ Chinese Med, Nursing Coll, Nanjing 210046, Jiangsu, Peoples R China.
   [Xu Xiao] Changzhou Univ, Nursing Coll, Changzhou 213164, Peoples R China.
C3 Jiangsu Vocational College of Medicine; Anhui University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Changzhou University
RP Xia, LP (corresponding author), Jiangsu Vocat Coll Med, Nursing Coll, Yancheng 224006, Peoples R China.
EM niggtgyx@163.com
RI Xu, Xiao/K-5069-2019; 孙, 志岭/HZI-1723-2023
OI Xu, Xiao/0000-0001-9272-6236; 
FU National Natural Science Foundation of China: Exploring the
   multi-targeted regulatory mechanisms of moxibustion on rheumatoid
   arthritis based on lipid signaling pathway networks [81774383];
   Outstanding Young Teachers' Overseas Training Program of Jiangsu Higher
   Education Institutions of China (2013); QingLan Project of Jiangsu
   Higher Education Institution of China (2014); Key Projects of Changzhou
   Municipal Health Committee:meridian flow theory based moxibustion
   intervention on ankylosing spondylitis [ZD201713]
FX Supported by the National Natural Science Foundation of China: Exploring
   the multi-targeted regulatory mechanisms of moxibustion on rheumatoid
   arthritis based on lipid signaling pathway networks (81774383),
   Outstanding Young Teachers' Overseas Training Program of Jiangsu Higher
   Education Institutions of China (2013), QingLan Project of Jiangsu
   Higher Education Institution of China (2014), and Key Projects of
   Changzhou Municipal Health Committee:meridian flow theory based
   moxibustion intervention on ankylosing spondylitis (ZD201713)
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NR 57
TC 13
Z9 16
U1 1
U2 17
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD OCT
PY 2019
VL 39
IS 5
BP 599
EP 608
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA JJ9WU
UT WOS:000494502900001
PM 32186109
DA 2026-01-16
ER

PT J
AU Zhu, ZX
   Chen, C
   Zheng, YF
   Gong, WL
   Chen, Z
   Fang, SL
   Shao, DH
   Sun, CX
AF Zhu, Zhi-xin
   Chen, Chen
   Zheng, Yong-feng
   Gong, Wei-li
   Chen, Zheng
   Fang, Shi-lei
   Shao, Dong-hua
   Sun, Cai-xia
TI Buccal Acupuncture Alleviates Postoperative Pain in Patients Undergoing
   Radical Resection of Gastrointestinal Cancers: A Randomized Controlled
   Pilot Study
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE buccal acupuncture; gastrointestinal cancers; acupuncture analgesia;
   postoperative pain; recovery quality; Chinese medicine
ID RECOVERY; SURGERY; TIME
AB ObjectiveTo preliminarily investigate the effect of buccal acupuncture therapy on ameliorating postoperative pain and enhancing recovery quality among patients undergoing radical resection of gastrointestinal cancers. MethodsFifty-two participants were randomized at a 1:1 ratio to either the buccal acupuncture or the control group. The acupuncture protocol entailed targeting 5 predetermined acupoints [CA-2 (Upper jiao), CA-3 (Middle jiao), CA-4 (Lower jiao), CA-6 (back), and CA-7 (waist) and two adjustable acupoints [CA-1 (head) and CA-8 (sacrum)] on each side of the face. The outcomes included the Numeric Rating Scale (NRS) scores for each day within 7 days postoperatively, 15-Item Quality of Recovery Scale (QoR-15) scores, analgesics consumption during and after surgery, incidences of postoperative nausea and vomiting, and perioperative levels of interleukin-6 and glucose. Adverse events related to acupuncture were recorded. ResultsOf the initial 52 participants, 46 completed the study and were included in the analysis. Findings indicated that the buccal acupuncture group experienced significantly reduced resting NRS scores in post-anesthesia care unit and throughout the postoperative phase (P=0.001 and P=0.003, respectively), along with enhanced QoR-15 scores on the 3rd postoperative day (P=0.008), compared to the control group. No notable differences were identified in the remaining indicators (P>0.05). ConclusionBuccal acupuncture therapy demonstrated significant effectiveness in reducing postoperative pain and improving recovery quality for patients undergoing radical resection of gastrointestinal cancers, presenting a viable intervention without associated adverse outcomes. (Trial registration No. ChiCTR2200060441)
C1 [Zhu, Zhi-xin; Chen, Chen; Zheng, Yong-feng; Chen, Zheng; Fang, Shi-lei; Shao, Dong-hua; Sun, Cai-xia] Jiangsu Univ, Affiliated Peoples Hosp, Dept Anesthesiol, Zhenjiang 212002, Jiangsu, Peoples R China.
   [Gong, Wei-li] Jiangsu Univ, Affiliated Peoples Hosp, Dept Acupuncture & Moxibust, Zhenjiang 212002, Jiangsu, Peoples R China.
C3 Jiangsu University; Jiangsu University
RP Sun, CX (corresponding author), Jiangsu Univ, Affiliated Peoples Hosp, Dept Anesthesiol, Zhenjiang 212002, Jiangsu, Peoples R China.
EM suncaixia_zj@126.com
RI zhu, zhixin/GXH-6167-2022
FU Chinese Medical Development Plan Projects of Jiangsu Province
   [MS2021083]; Science and Technology Planning Social Development Project
   of Zhenjiang City [SH2022071]
FX Supported by the Chinese Medical Development Plan Projects of Jiangsu
   Province (No. MS2021083), and the Science and Technology Planning Social
   Development Project of Zhenjiang City (No. SH2022071)
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NR 37
TC 1
Z9 1
U1 5
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD JUN
PY 2025
VL 31
IS 6
BP 558
EP 565
DI 10.1007/s11655-025-4128-y
EA MAR 2025
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2QM5K
UT WOS:001444344800001
PM 40080251
DA 2026-01-16
ER

PT J
AU Li, YM
   Wang, DQ
   Sun, J
   Hao, ZK
   Tang, LT
   Sun, WR
   Zhang, XH
   Wang, PY
   Ruiz-Alonso, S
   Pedraz, JL
   Kim, HW
   Ramalingam, M
   Xie, SY
   Wang, RR
AF Li, Yunmeng
   Wang, Deqiang
   Sun, Jian
   Hao, Zhaokun
   Tang, Letian
   Sun, Wanru
   Zhang, Xuehua
   Wang, Pingyu
   Ruiz-Alonso, Sandra
   Pedraz, Jose Luis
   Kim, Hae-Won
   Ramalingam, Murugan
   Xie, Shuyang
   Wang, Ranran
TI Calcium Carbonate/Polydopamine Composite Nanoplatform Based on TGF-β
   Blockade for Comfortable Cancer Immunotherapy
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE calcium carbonate/polydopamine; curcumin; ropivacaine; composite
   nanoplatform; TGF-beta blockade; comfortable cancer immunotherapy
ID COMBINATION THERAPY; ROPIVACAINE; PAIN; ELECTROACUPUNCTURE;
   NANOPARTICLES; CHEMOTHERAPY; ULTRASOUND; EXPRESSION; CELLS
AB Cancer pain seriously reduces the quality of life of cancer patients. However, most research about cancer focuses solely on inhibiting tumor growth, neglecting the issue of cancer pain. Therefore, the development of therapeutic agents with both tumor suppression and cancer pain relief is crucial to achieve human-centered treatment. Here, the work reports curcumin (CUR) and ropivacaine (Ropi) coincorporating CaCO3/PDA nanoparticles (CaPNMCUR+Ropi) that realized efficient tumor immunotherapy and cancer pain suppression. The therapeutic efficiency and mechanism are revealed in vitro and in vivo. The results indicate that CaPNMCUR+Ropi underwent tumor microenvironment-responsive degradation and realized rapid release of calcium ions, Ropi, and CUR. The excessive intracellular calcium triggered the apoptosis of tumor cells, and the transient pain caused by the tumor injection was relieved by Ropi. Simultaneously, CUR reduced the levels of immunosuppressive factor (TGF-beta) and inflammatory factor (IL-6, IL-1 beta, and TNF-alpha) in the tumor microenvironment, thereby continuously augmenting the immune response and alleviating inflammatory pain of cancer animals. Meanwhile, the decrease of TGF-beta leads to the reduction of transient receptor potential vanilloid 1 (TRPV1) expression, thereby alleviating hyperalgesia and achieving long-lasting analgesic effects. The design of the nanosystem provides a novel idea for human-centered tumor treatment in the future.
C1 [Li, Yunmeng; Sun, Jian; Hao, Zhaokun; Tang, Letian; Sun, Wanru; Wang, Ranran] Binzhou Med Univ, Inst Rehabil Med Special Educ & Rehabil, Yantai 264003, Peoples R China.
   [Li, Yunmeng; Xie, Shuyang; Wang, Ranran] Shandong Lab Adv Mat & Green Mfg, Yantai 264000, Peoples R China.
   [Li, Yunmeng; Wang, Pingyu; Xie, Shuyang] Binzhou Med Univ, Key Lab Tumor Mol Biol, Yantai 264003, Peoples R China.
   [Wang, Deqiang] Binzhou Med Univ Hosp, Binzhou 256603, Peoples R China.
   [Zhang, Xuehua] Liaocheng Peoples Hosp, Dept Precis Biomed Lab, Liaocheng 252000, Peoples R China.
   [Ruiz-Alonso, Sandra; Pedraz, Jose Luis; Ramalingam, Murugan] Univ Basque Country UPV EHU, Fac Pharm, Dept Pharm & Food Sci, Lab Pharm & Pharmaceut Technol,NanoBiocel Grp, Vitoria 01006, Spain.
   [Ruiz-Alonso, Sandra; Pedraz, Jose Luis; Ramalingam, Murugan] Bioaraba Hlth Res Inst, Vitoria 01009, Spain.
   [Ruiz-Alonso, Sandra; Pedraz, Jose Luis; Ramalingam, Murugan] Inst Hlth Carlos III, Biomed Res Networking Ctr Bioengn Biomat & Nanome, Madrid 28029, Spain.
   [Kim, Hae-Won] Dankook Univ, Inst Tissue Regenerat Engn, Dept Nanobiomed Sci, NBM Global Res Ctr Regenerat Med BK21, Cheonan 31116, South Korea.
   [Kim, Hae-Won] Dankook Univ, Mechanobiol Dent Med Res Ctr, Cheonan 31116, South Korea.
   [Ramalingam, Murugan] Ctr Invest Lascaray Ikergunea, Joint Res Lab JRL Bioprinting & Adv Pharm Dev, Ave Miguel de Unamuno, Vitoria 01006, Spain.
   [Ramalingam, Murugan] Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain.
   [Ramalingam, Murugan] Chengdu Univ, Sch Basic Med Sci, Chengdu 610106, Peoples R China.
   [Ramalingam, Murugan] Binzhou Med Univ, Sch Basic Med Sci, Yantai 264003, Peoples R China.
   [Ramalingam, Murugan] Atilim Univ, Dept Met & Mat Engn, TR-06830 Ankara, Turkiye.
C3 Binzhou Medical University; Shandong Laboratory of Advanced Materials &
   Green Manufacturing at Yantai; Binzhou Medical University; Binzhou
   Medical University; University of Basque Country; Bioaraba Health
   Research Institute; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERBBN; Dankook University; Dankook University; Basque Foundation for
   Science; Chengdu University; Binzhou Medical University; Atilim
   University
RP Wang, RR (corresponding author), Binzhou Med Univ, Inst Rehabil Med Special Educ & Rehabil, Yantai 264003, Peoples R China.; Xie, SY; Wang, RR (corresponding author), Shandong Lab Adv Mat & Green Mfg, Yantai 264000, Peoples R China.; Xie, SY (corresponding author), Binzhou Med Univ, Key Lab Tumor Mol Biol, Yantai 264003, Peoples R China.; Ramalingam, M (corresponding author), Univ Basque Country UPV EHU, Fac Pharm, Dept Pharm & Food Sci, Lab Pharm & Pharmaceut Technol,NanoBiocel Grp, Vitoria 01006, Spain.; Ramalingam, M (corresponding author), Bioaraba Hlth Res Inst, Vitoria 01009, Spain.; Ramalingam, M (corresponding author), Inst Hlth Carlos III, Biomed Res Networking Ctr Bioengn Biomat & Nanome, Madrid 28029, Spain.; Ramalingam, M (corresponding author), Ctr Invest Lascaray Ikergunea, Joint Res Lab JRL Bioprinting & Adv Pharm Dev, Ave Miguel de Unamuno, Vitoria 01006, Spain.; Ramalingam, M (corresponding author), Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain.; Ramalingam, M (corresponding author), Chengdu Univ, Sch Basic Med Sci, Chengdu 610106, Peoples R China.; Ramalingam, M (corresponding author), Binzhou Med Univ, Sch Basic Med Sci, Yantai 264003, Peoples R China.; Ramalingam, M (corresponding author), Atilim Univ, Dept Met & Mat Engn, TR-06830 Ankara, Turkiye.
EM rmurug2000@gmail.com; shuyangxie@aliyun.com; wangrr@bzmc.edu.cn
RI Pedraz, Jose/AAR-1338-2021; Zhang, Xuehua/GVS-4930-2022; Ramalingam,
   Murugan/AAV-1702-2020
OI Ramalingam, Murugan/0000-0001-6498-9792; Ruiz-Alonso,
   Sana/0000-0003-4839-5825
FU National Research Foundation of Korea [2022KJ091]; Education Department
   of Shandong Province [51903015, 81772281]; National Natural Science
   Foundation of China [AMGM2021F03, AMGM2023F16]; Science Fund of Shandong
   Laboratory of Advanced Materials and Green Manufacturing at Yantai
   [ZR2022LSW002, ZR2020KH015]; Shandong Science and Technology Committee
   [50012304274]; Scientific Research Foundation of Binzhou Medical
   University [ts201712067]; Shandong Province Taishan Scholar Project;
   Nanomedicine (CIBER-BBN) at the University of the Basque Country
   (UPV/EHU) [2018K1A4A3A01064257, 2021R1A5A2022318]; National Research
   Foundation of Korea; Dankook University Priority Institute Support
   Program in 2023
FX This work was supported by the Education Department of Shandong Province
   (no. 2022KJ091), National Natural Science Foundation of China (grant
   nos. 51903015 and 81772281), Science Fund of Shandong Laboratory of
   Advanced Materials and Green Manufacturing at Yantai (AMGM2021F03 and
   AMGM2023F16), Shandong Science and Technology Committee (nos.
   ZR2022LSW002 and ZR2020KH015), Scientific Research Foundation of Binzhou
   Medical University (no. 50012304274), Shandong Province Taishan Scholar
   Project (no. ts201712067), ICTS "NANBIOSIS", particularly by the Drug
   Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and
   Nanomedicine (CIBER-BBN) at the University of the Basque Country
   (UPV/EHU), National Research Foundation of Korea (2018K1A4A3A01064257
   and 2021R1A5A2022318), and Dankook University Priority Institute Support
   Program in 2023.
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NR 72
TC 3
Z9 5
U1 9
U2 60
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
EI 1944-8252
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD JAN 11
PY 2024
VL 16
IS 3
BP 3187
EP 3201
DI 10.1021/acsami.3c16571
PG 15
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA GD1D2
UT WOS:001150625900001
PM 38206677
DA 2026-01-16
ER

PT J
AU D'Alessandro, E
   de Brito, C
   Cecatto, R
   Saul, M
   Atta, JA
   Lin, CA
AF D'Alessandro, Eduardo
   de Brito, Christina
   Cecatto, Rebeca
   Saul, Maira
   Atta, Jose Antonio
   Lin, Chin An
TI Evaluation of acupuncture for cancer symptoms in a cancer institute in
   Brazil
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID ELECTROACUPUNCTURE; COMPLEMENTARY; XEROSTOMIA; EFFICACY; TRIALS; PAIN
AB Introduction Acupuncture has been progressively included in the practice of mainstream medicine in recent decades. The State of Sao Paulo Cancer Institute is a public hospital established in 2008 and its acupuncture service follows the experience and model of several oncology centres in the USA, aiming to optimise the treatment of symptoms such as postoperative pain, oncological pain, neuropathic pain, nausea, vomiting, xerostomia and fatigue induced by chemotherapy. This paper describes the population given acupuncture treatment and the effects of the intervention on symptom management.
   Methods One hundred and eighty-three patients from our service were enrolled in the study. Baseline and final symptom intensity was recorded using a visual analogue score (VAS) ranging from 0 to 10 cm, with a higher score meaning higher symptom intensity.
   Results Fifty-four (29.50%) were receiving active treatment with chemotherapy and/or radiotherapy, 29 (15.85%) were receiving hormone therapy and 100 (54.65%) were considered to be in remission. The main symptoms were: oncological pain in 44 (24.04%), chemotoxicity in 34(18.6%), lumbar pain in 53 (28.96%) and chronic postoperative pain in 54(28.4%). The mean (SD) initial symptom score was 7.04 (1.8), which was reduced to 2.56 (2.75) after treatment (p<0.001), an improvement of 63.6% in control of the symptoms. Further analysis of the data showed that the effect was similar in different indications for acupuncture treatment.
   Conclusions Use of acupuncture may have improved symptom control in patients enrolled in this study.
C1 [D'Alessandro, Eduardo] Sao Paulo State Inst Canc, Dept Internal Med, BR-05403000 Sao Paulo, Brazil.
   [de Brito, Christina; Cecatto, Rebeca; Saul, Maira; Atta, Jose Antonio] Sao Paulo State Inst Canc, Dept Rehabil Med, BR-05403000 Sao Paulo, Brazil.
   [Atta, Jose Antonio] Univ Sao Paulo, Fac Med, Clin Hosp, Dept Internal Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP D'Alessandro, E (corresponding author), Sao Paulo State Inst Canc, Av Dr Eneas de Carvalho Aguiar,255 Cerqueira Cesa, BR-05403000 Sao Paulo, Brazil.
EM e.g.dalessandro@gmail.com
RI Moran de Brito, Christina May/I-7269-2012; Cecatto, Rebeca/B-7338-2013
OI Moran de Brito, Christina May/0000-0003-3775-6533; Cecatto,
   Rebeca/0000-0001-5675-6665; D'Alessano, Eduardo/0000-0001-7146-8530
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
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NR 15
TC 7
Z9 8
U1 0
U2 21
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD MAR
PY 2013
VL 31
IS 1
BP 23
EP 26
DI 10.1136/acupmed-2012-010206
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 109MC
UT WOS:000316371700006
PM 23117345
DA 2026-01-16
ER

PT J
AU Lee, J
   Yoon, SW
AF Lee, Jinsoo
   Yoon, Seong Woo
TI Efficacy and Safety of Moxibustion for Relieving Pain in Patients With
   Metastatic Cancer: A Pilot, Randomized, Single-Blind, Sham-Controlled
   Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE moxibustion; cancer pain; true moxibustion; sham moxibustion; metastatic
   cancer
ID QUALITY-OF-LIFE; FUNCTIONAL ASSESSMENT; ACUPUNCTURE; VALIDATION;
   PREVALENCE; MANAGEMENT; SCALE; CARE
AB Background. Moxibustion has been traditionally used to manage pain related to chronic diseases, including cancer. This study aims to investigate the efficacy and safety of moxibustion for relieving cancer pain in patients with metastatic cancer. Methods. A total of 16 patients were randomly divided into a true moxibustion (TM) group or a sham moxibustion (SM) group. In both groups, moxibustion was applied for 10 minutes, once daily for 7 consecutive days. In the SM group, the moxa cone was removed earlier than in the TM group, so as not to deliver heat stimulation completely into the skin. The changes of pain severity using the Brief Pain Inventory (BPI) and quality of life measured by the Functional Assessment of Cancer Therapy-General (FACT-G) were observed. A blinding credibility test was done to validate the sham moxibustion procedure. Results. The total BPI score significantly decreased in the TM group compared with the SM group (TM vs SM: -0.97 +/- 1.05 vs 0.35 +/- 0.60, P = .025). The 2 subsets of BPI, pain intensity score and pain interference score, also significantly decreased in the TM group (TM vs SM: intensity, -0.82 +/- 0.93 vs 0.46 +/- 0.87, P = .020; interference, -1.12 +/- 1.31 vs 0.24 +/- 0.61, P = .047). Even after adjusting for the values of opioid consumption, these results remained significant. FACT-G did not significantly improve in the TM group. The blinding to sham moxibustion was credible and no serious adverse events occurred. Conclusion. We suggest that moxibustion could be a safe and potential modality for cancer-related pain in patients with metastatic cancer. With the limitation of small sample size, a larger and long-term follow-up study is necessary to determine more definitely the efficacy of moxibustion.
C1 [Lee, Jinsoo; Yoon, Seong Woo] Kyung Hee Univ, Korean Med Hosp Gangdong, Seoul 130090, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital
RP Yoon, SW (corresponding author), Kyung Hee Univ, Korean Med Hosp Gangdong, Dept Korean Internal Med, 149 Sangil Dong, Seoul 130090, South Korea.
EM stepano212@hanmail.net
RI Yoon, Seong/AAJ-8763-2020
FU Clinical Research Institute, Kyung Hee University Hospital at Gangdong
   [KHNMCCRI-2010-03]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by Clinical Research Institute, Kyung Hee University
   Hospital at Gangdong in 2010 (KHNMCCRI-2010-03).
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NR 31
TC 19
Z9 26
U1 0
U2 26
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAY
PY 2014
VL 13
IS 3
BP 211
EP 216
DI 10.1177/1534735413510025
PG 6
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA AH6UE
UT WOS:000336265900008
PM 24282101
OA gold
DA 2026-01-16
ER

PT J
AU Bao, T
   Ye, XB
   Skinner, J
   Cao, B
   Fisher, J
   Nesbit, S
   Grossman, SA
AF Bao, Ting
   Ye, Xiaobu
   Skinner, Janice
   Cao, Bing
   Fisher, Joy
   Nesbit, Suzanne
   Grossman, Stuart A.
TI The Analgesic Effect of Magnetic Acupressure in Cancer Patients
   Undergoing Bone Marrow Aspiration and Biopsy: A Randomized, Blinded,
   Controlled Trial
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Acupressure; pain; bone marrow aspiration and biopsy
ID ACUPUNCTURE; PAIN; OSTEOARTHRITIS; LABOR
AB Context. Bone marrow aspiration and biopsy (BMAB) is a frequently performed and painful procedure.
   Objectives. To evaluate the efficacy of magnetic acupressure in reducing pain in cancer patients undergoing BMAB.
   Methods. Cancer patients without previous acupuncture or acupressure experience were stratified by the number of prior BMAB and randomized to having magnetic acupressure delivered to either the large intestine 4 (LI4) acupoint or a sham site. The primary study endpoint was the patient's pain intensity rating during the procedure using a visual analogue scale (VAS).
   Results. Seventy-seven eligible patients received magnetic acupressure: 37 were randomized to treatment at the LI4 site arm and 40 at the designated sham site arm. There was no significant difference between the median pain scores of patients treated at the LI4 site and the sham site (P = 0.87). However, severe pain (VAS >= 7) was reported in only one patient (2.7%) treated at the LI4 site compared with eight patients (20%) at the sham site (P = 0.03). No patients experienced significant magnetic acupressure-related toxicities.
   Conclusion. Magnetic acupressure at the LI4 acupoint requires minimal training and expense and is well tolerated. Although its use did not significantly reduce median pain scores in patients undergoing BMAB, it does appear to reduce the proportion of patients with severe pain associated with this invasive procedure. J Pain Symptom Manage 2011; 41: 995-1002. (C) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
C1 [Bao, Ting] Univ Maryland, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21212 USA.
   [Bao, Ting] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21212 USA.
   [Ye, Xiaobu; Skinner, Janice; Cao, Bing; Fisher, Joy; Nesbit, Suzanne; Grossman, Stuart A.] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Medicine
RP Bao, T (corresponding author), Univ Maryland, Greenebaum Canc Ctr, 22 S Greene St,Room N9E24, Baltimore, MD 21212 USA.
EM tingbao@gmail.com
RI Nesbit, Suzanne/AAU-4032-2020
OI Bao, Ting/0000-0003-4437-2597
CR [Anonymous], JAMA
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NR 19
TC 25
Z9 26
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0885-3924
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JUN
PY 2011
VL 41
IS 6
BP 995
EP 1002
DI 10.1016/j.jpainsymman.2010.08.012
PG 8
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 779VG
UT WOS:000291809700006
PM 21306863
DA 2026-01-16
ER

PT J
AU Chen, YW
   Li, MZ
   Guo, KX
AF Chen, Yuwei
   Li, Mingzhu
   Guo, Kaixin
TI Exploring the mechanisms and current status of acupuncture in
   alleviating tumor metabolism and associated diseases: Insights from the
   central nervous system and immune microenvironment
SO SLAS TECHNOLOGY
LA English
DT Article
DE Acupuncture; Tumor-related diseases; Tumor metabolism; Central nervous
   system; Endocrine System; Immune microenvironment
ID QUALITY-OF-LIFE; CANCER-PATIENTS; GASTRIC-CANCER; BREAST-CANCER;
   MOLECULAR-MECHANISMS; LASER ACUPUNCTURE; PAIN MANAGEMENT; MOUSE MODEL;
   ELECTROACUPUNCTURE; STIMULATION
AB Acupuncture, as a traditional Chinese medical treatment, has garnered increasing attention in recent years in fields such as tumor metabolism, the central nervous system, and the immune microenvironment. This paper aims to explore the fundamental principles, mechanisms, and research status of acupuncture therapy for tumorrelated diseases. Firstly, we introduce the basic principles of acupuncture therapy, including the theories of meridians and its theoretical basis in tumor treatment. Secondly, we systematically review the mechanisms of acupuncture therapy for tumor-related diseases, discussing how acupuncture alleviates side effects such as pain, depression, fatigue, and gastrointestinal discomfort caused by conventional treatments through modulation of the immune microenvironment, central nervous system, and endocrine system. Subsequently, we discuss the current research status of acupuncture therapy for tumor-related diseases, as well as the application of current research methods and technologies in elucidating acupuncture mechanisms. Additionally, by combining clinical practice with different types of tumor-related diseases as experimental subjects, we demonstrate the application effectiveness and clinical practice experience of acupuncture in tumor treatment. Finally, a comprehensive assessment of acupuncture therapy for tumor-related diseases is provided, summarizing its limitations and prospecting future directions, including interdisciplinary collaboration and personalized treatment. In conclusion, acupuncture, as a feasible adjunctive therapy, is closely related to the central nervous system and the immune microenvironment, holding potential significant value in tumor treatment.
C1 [Chen, Yuwei; Li, Mingzhu] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250000, Peoples R China.
   [Guo, Kaixin] Shandong Univ Tradit Chinese Med, Dept Acupuncture, Jinan 250000, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Guo, KX (corresponding author), Shandong Univ Tradit Chinese Med, Dept Acupuncture, Jinan 250000, Peoples R China.
EM 2022111036@sdutcm.edu.cn; 2022111031@sdutcm.edu.cn; 17860505418@163.com
RI li, mingzhu/NQE-9241-2025
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NR 189
TC 6
Z9 6
U1 12
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2472-6303
EI 2472-6311
J9 SLAS TECHNOL
JI SLAS Technol.
PD DEC
PY 2024
VL 29
IS 6
AR 100208
DI 10.1016/j.slast.2024.100208
EA OCT 2024
PG 17
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA L3J0F
UT WOS:001349703600001
PM 39396727
OA gold
DA 2026-01-16
ER

PT J
AU Choi, TY
   Lee, MS
   Kim, TH
   Zaslawski, C
   Ernst, E
AF Choi, Tae-Young
   Lee, Myeong Soo
   Kim, Tae-Hun
   Zaslawski, Christopher
   Ernst, Edzard
TI Acupuncture for the treatment of cancer pain: a systematic review of
   randomised clinical trials
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Acupuncture; Cancer pain; Systematic review; Complementary and
   alternative medicine
ID ELECTROACUPUNCTURE; MANAGEMENT; EXPRESSION; ISSUES
AB Controlling cancer-related pain is an important component in the palliative care of cancer patients. The objective of this review was to assess the effectiveness of acupuncture for treating cancer pain.
   Fourteen databases were searched from their inception through April 2011. Randomised clinical trials (RCTs) were included if acupuncture was used as the sole treatment or as a part of a combination therapy for cancer pain. Studies were included if they were controlled with a placebo or controlled against a drug-therapy or no-treatment group. The Cochrane criteria were used to assess the risk of bias.
   A total of 15 RCTs met our inclusion criteria. All of the included RCTs were associated with a high risk of bias. The majority of acupuncture treatments or combination therapies with analgesics exhibited favourable effects compared with conventional treatments in individual studies. However, a meta-analysis suggested that acupuncture did not generate a better effect than drug therapy (n = 886; risk ratio (RR), 1.12; 95% CI 0.98 to 1.28; P = 0.09). The comparison between acupuncture plus drug therapy and drug therapy alone demonstrated a significant difference in favour of the combination therapy (n = 437; RR, 1.36; 95% CI 1.13 to 1.64; P = 0.003). The results of this systematic review provide no strong evidence for the effectiveness of acupuncture in the management of cancer pain.
   The total number of RCTs included in the analysis and their methodological quality were too low to draw firm conclusions. Future rigorous RCTs will be necessary to assess the clinical efficacy of acupuncture in this area.
C1 [Choi, Tae-Young; Lee, Myeong Soo; Kim, Tae-Hun] Korea Inst Oriental Med, Div Med Res, Taejon 305811, South Korea.
   [Ernst, Edzard] Univ Exeter, Peninsula Med Sch, Exeter, Devon, England.
   [Zaslawski, Christopher] Univ Technol Sydney, Coll Tradit Chinese Med, Sydney, NSW 2007, Australia.
C3 Korea Institute of Oriental Medicine (KIOM); University of Exeter;
   University of Technology Sydney
RP Lee, MS (corresponding author), Korea Inst Oriental Med, Div Med Res, Taejon 305811, South Korea.
EM drmslee@gmail.com
RI Lee, Myeong Soo/C-8147-2013; Kim, Tae-Hun/G-8728-2014; Choi,
   TaeYoung/PAU-6282-2025
OI Lee, Myeong Soo/0000-0001-6651-7641; Choi,
   Tae-Young/0000-0003-0638-2153; Kim, Tae-Hun/0000-0002-8448-3219; 
FU Korea Institute of Oriental Medicine [K11111, K11130]
FX Tae-Young Choi and Myeong Soo Lee were supported by Korea Institute of
   Oriental Medicine (K11111 and K11130).
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NR 55
TC 81
Z9 92
U1 0
U2 42
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUN
PY 2012
VL 20
IS 6
BP 1147
EP 1158
DI 10.1007/s00520-012-1432-9
PG 12
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 935PN
UT WOS:000303532000005
PM 22447366
DA 2026-01-16
ER

PT J
AU Wang, N
   Zhao, L
   Zhang, D
   Kong, FM
AF Wang, Na
   Zhao, Lu
   Zhang, Dou
   Kong, Fanming
TI Research progress on the immunomodulatory mechanism of acupuncture in
   tumor immune microenvironment
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE acupuncture; tumor immune microenvironment; traditional Chinese
   medicine; immunotherapy; cancer immunity
ID CANCER-PATIENTS; M2 MACROPHAGES; ELECTROACUPUNCTURE; CELLS; INNATE;
   PAIN; IMMUNOSUPPRESSION; ACTIVATION; ACUPOINT; EFFICACY
AB With the constantly deeper understanding of individualized precision therapy, immunotherapy is increasingly developed and personalized. The tumor immune microenvironment (TIME) mainly consists of infiltrating immune cells, neuroendocrine cells, extracellular matrix, lymphatic vessel network, etc. It is the internal environment basis for the survival and development of tumor cells. As a characteristic treatment of traditional Chinese medicine, acupuncture has shown potentially beneficial impacts on TIME. The currently available information demonstrated that acupuncture could regulate the state of immunosuppression through a range of pathways. An effective way to understand the mechanisms of action of acupuncture was to analyze the response following treatment of the immune system. This research reviewed the mechanisms of acupuncture regulating tumor immunological status based on innate and adaptive immunity.
C1 [Wang, Na; Zhao, Lu; Zhang, Dou; Kong, Fanming] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Oncol, Tianjin, Peoples R China.
   [Wang, Na; Zhao, Lu; Zhang, Dou; Kong, Fanming] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Kong, FM (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Oncol, Tianjin, Peoples R China.; Kong, FM (corresponding author), Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China.
EM kongfanming08@163.com
FU National Natural Science Foundation of China [81403220]; National Key
   Research and Development (RD) Plan [2018YFC1707400]; Tianjin Health and
   Family Planning-high Level Talent Selection and Training Project
FX Funding This work was supported by grants from the National Natural
   Science Foundation of China (No. 81403220), the National Key Research
   and Development (R&D) Plan (No.2018YFC1707400), and the Tianjin Health
   and Family Planning-high Level Talent Selection and Training Project.
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NR 90
TC 14
Z9 18
U1 10
U2 76
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 14
PY 2023
VL 14
AR 1092402
DI 10.3389/fimmu.2023.1092402
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 9I8BF
UT WOS:000939728000001
PM 36865562
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liou, KT
   Baser, R
   Romero, SAD
   Green, J
   Li, QS
   Orlow, I
   Panageas, KS
   Mao, JJ
AF Liou, Kevin T.
   Baser, Ray
   Romero, Sally A. D.
   Green, Jamie
   Li, Q. Susan
   Orlow, Irene
   Panageas, Katherine S.
   Mao, Jun J.
TI Personalized electro-acupuncture versus auricular-acupuncture
   comparative effectiveness (PEACE): A protocol of a randomized controlled
   trial for chronic musculoskeletal pain in cancer survivors
SO MEDICINE
LA English
DT Article
DE cancer; acupuncture; chronic pain; comparative effectiveness; pain
   management; personalized medicine
ID SLEEP QUALITY INDEX; BATTLEFIELD ACUPUNCTURE; HOSPITAL ANXIETY;
   INFORMATION; STIMULATION; RELIABILITY; ARTHRALGIA; VALIDATION;
   EXPECTANCY; STRATEGIES
AB Introduction: Chronic pain is a leading cause of disability and remains under-treated in nearly half of patients with cancer. The opioid crisis has highlighted an urgent public health need for effective nonpharmacological pain management. Electroacupuncture (EA) and Battlefield Acupuncture (BFA) represent nonpharmacological modalities used in clinical practice to manage pain; however, their effectiveness has not been rigorously evaluated in oncology settings. Methods: We describe the design of a 3-arm, parallel, single-center, multisite randomized controlled trial that investigates EA and BFA versus usual-care wait-list control (WLC) for chronic musculoskeletal pain among 360 patients with diverse cancer types across various stages. The primary aim is to compare effects of EA and BFA versus WLC on pain, physical function, and co-morbid symptoms. The secondary aim is to examine the interaction between patient outcome expectancy and acupuncture modality (EA vs BFA) on pain reduction. The tertiary aim is to evaluate the association between genetic polymorphisms and responses to acupuncture. Patients will be randomized in a 2:2:1 ratio to EA:BFA:WLC. Acupuncture groups will receive weekly treatments over 10 weeks. WLC will receive usual care over the same evaluation period as the acupuncture groups. The primary endpoint will be the change in average pain intensity score from baseline to week 12. We will collect validated patient-reported outcomes and blood/saliva samples at multiple timepoints over 24 weeks. Discussion: Our findings will advance nonpharmacological pain management in oncology and inform personalized treatment approaches that integrate individuals' expectations and genetic biomarkers to deliver "precision" acupuncture to cancer patients with chronic pain.
C1 [Liou, Kevin T.; Green, Jamie; Li, Q. Susan; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, Dept Med, New York, NY 10021 USA.
   [Baser, Ray; Orlow, Irene; Panageas, Katherine S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
   [Romero, Sally A. D.] UC San Diego Sch Med, Dept Family Med & Publ Hlth, San Diego, CA USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
OI Liou, Kevin/0000-0002-2438-9749
FU U.S. Department of Defense [W81XWH-15-1-0245]; National Institutes of
   Health/National Cancer Institute [P30 CA008748]; Translational and
   Integrative Medicine Research Fund at Memorial Sloan Kettering Cancer
   Center; National Cancer Institute [P30CA008748] Funding Source: NIH
   RePORTER
FX Research reported in this article was funded by a U.S. Department of
   Defense grant (W81XWH-15-1-0245), a grant from the National Institutes
   of Health/National Cancer Institute (P30 CA008748) and the Translational
   and Integrative Medicine Research Fund at Memorial Sloan Kettering
   Cancer Center. The statements presented in this article are solely the
   responsibility of the authors and do not necessarily represent the views
   of the funders. The funders did not have any role in study design;
   collection, management, analysis, and interpretation of data; writing of
   the report; and decision to submit for publication.
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NR 78
TC 16
Z9 20
U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 22
PY 2020
VL 99
IS 21
AR e20085
DI 10.1097/MD.0000000000020085
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA MO4OT
UT WOS:000551508200030
PM 32481275
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mao, HJ
   Mao, JJ
   Chen, JC
   Li, Q
   Chen, XF
   Shen, XB
   Zhao, L
   Wei, JZ
   Shen, XY
AF Mao, Huijuan
   Mao, Jun J.
   Chen, Junchao
   Li, Qing
   Chen, Xuefen
   Shen, Xubo
   Zhao, Ling
   Wei, Jianzi
   Shen, Xueyong
TI Effects of infrared laser moxibustion on cancer-related fatigue in
   breast cancer survivors Study protocol for a randomized controlled trial
SO MEDICINE
LA English
DT Article
DE acupuncture; breast cancer; cancer survivor; cancer-related fatigue;
   infrared laser; moxibustion
ID QUALITY-OF-LIFE; CHINESE VERSION; TELOMERE LENGTH; DEPRESSION SCALE;
   HOSPITAL ANXIETY; RISK-FACTORS; BRIEF PAIN; ACUPUNCTURE; VALIDATION;
   STRESS
AB Background: Cancer-related fatigue (CRF) is the most common and distressing symptom associated with cancer treatment that breast cancer survivors (BCS) experience. We previously found that laser moxibustion may be efficacious for CRF. The primary aim of this study is to determine the specific efficacy of 10.6mm infrared laser moxibustion on CRF. The secondary aim is to evaluate the effect of infrared laser moxibustion on co-existing symptoms that BCS experience. Methods: We will conduct a randomized, sham-controlled, three-arm trial of infrared laser moxibustion (ILM) against sham ILM (SILM) and waitlist control (WLC) among BCS with moderate to severe fatigue. The two intervention groups will receive either real or sham infrared laser moxibustion on four acupoints (i.e., ST36 [bilateral], CV4, and CV6) for 20 minutes each session for 6 weeks (twice per week). The primary endpoint is the change in fatigue score from Baseline to Week 6 as measured by the Chinese version of the Brief Fatigue Inventory (BFI-C). Our secondary aim is to compare the severity of co-morbidities (e. g., depression, insomnia, and pain) among the 3 groups. Discussion: The results of our trial will establish evidence for the efficacy of infrared laser moxibustion for CRF, a very common and challenging symptom.
C1 [Mao, Huijuan; Zhao, Ling; Wei, Jianzi; Shen, Xueyong] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Mao, Jun J.; Li, Qing] Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Chen, Junchao] Shanghai Univ Tradit Chinese Med, Inst Disciplinary Sci, Shanghai, Peoples R China.
   [Chen, Xuefen] Shanghai Univ Tradit Chinese Med, Sch Publ Hlth, Shanghai, Peoples R China.
   [Shen, Xubo] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai, Peoples R China.
   [Shen, Xueyong] Shanghai Res Ctr Acupuncture & Meridian, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Memorial Sloan
   Kettering Cancer Center; Shanghai University of Traditional Chinese
   Medicine; Shanghai University of Traditional Chinese Medicine; Shanghai
   University of Traditional Chinese Medicine
RP Shen, XY (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM snowysh@hotmail.com
FU National Natural Science Foundation of China [81603703]; Shanghai
   Municipal Commission of Health and Family Planning [201840171]; National
   Institutes of Health/National Cancer Institute Cancer Center grant [P30
   CA008748]; MSK Translational Research and Integrative Medicine Fund;
   National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER
FX This research is funded in part by grants from the National Natural
   Science Foundation of China (grant number 81603703), and the Shanghai
   Municipal Commission of Health and Family Planning (grant number
   201840171). JJM is supported in part by a National Institutes of
   Health/National Cancer Institute Cancer Center grant (grant number P30
   CA008748) and the MSK Translational Research and Integrative Medicine
   Fund.
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NR 56
TC 9
Z9 10
U1 0
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2019
VL 98
IS 34
AR e16882
DI 10.1097/MD.0000000000016882
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IY4SJ
UT WOS:000486383000028
PM 31441863
OA Green Published, gold
DA 2026-01-16
ER

PT J
AU Mai, QL
   Li, XJ
   Yang, D
   Zhang, XY
   Peng, K
   Hao, YF
AF Mai, Qiulu
   Li, Xuejing
   Yang, Dan
   Zhang, Xiaoyan
   Peng, Ke
   Hao, Yufang
TI Effects of acupressure on cancer-related pain management: A systematic
   review and meta-analysis of randomized controlled trials
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Cancer pain; Acupressure; Pain intensity; Pain remission rate;
   Systematic review; Meta-analysis
ID MEDICINE
AB Introduction: Acupressure is a non-invasive complementary treatment method that can positively affect the relief of cancer pain symptoms. The results from clinical trials have revealed that the effects of acupressure (including auricular acupressure) on cancer pain management are inconsistent. Our objective was to systematically evaluate the effect of acupressure on cancer pain.& nbsp;Methods: Seven databases (CNKI, VIP, Wanfang Database, SinoMed, Pubmed, Embase, and The Cochrane Library) were searched from their inception to November 2021 for randomized controlled trials (RCTs) of acupressure used for cancer pain. All analyses were conducted by RevMan5.3. The Cochrane RoB tool and GRADE were used to assess the risk bias and quality of evidence, respectively.& nbsp;Results: Twenty-eight RCTs involving 2630 patients were included. Combined results showed the acupressure group had better outcomes in pain remission rate [RR 1.20, 95%CI (1.10, 1.30), P < 0.0001, I-2= 61%], pain intensity [SMD-1.78, 95% CI, (-2.21,-1.35), P < 0.00001, I-2= 94%], quality of life [SMD 0.62, 95%CI (0.35, 0.89), P < 0.00001, I-2=61%], patient satisfaction with analgesia [RR 1.14, 95%CI (1.05, 1.23), P = 0.001, I-2=43%] compared with a control group. Two studies mentioned that acupressure as an adjunctive treatment could reduce the dose of analgesics. The bias of most studies was unclear because of irregular reporting according to the ROB tool, and meanwhile, most studies had high risk with no blinding. The GRADE evidence level was rated as moderate to very low. No studies measured adverse reactions.& nbsp;Conclusion: Acupressure (including auricular acupressure) group seemed to be more effective than the control group for cancer pain. However, the results were inconclusive due to weak evidence, and robust methodological RCTs with appropriate blinding are still needed to reconfirm the findings of our review.
C1 [Mai, Qiulu; Li, Xuejing; Yang, Dan; Zhang, Xiaoyan; Peng, Ke; Hao, Yufang] Beijing Univ Chinese Med, Sch Nursing, 11 Beisanhuandonglu, Beijing, Peoples R China.
   [Mai, Qiulu; Li, Xuejing; Yang, Dan; Zhang, Xiaoyan; Peng, Ke; Hao, Yufang] Beijing Univ Chinese Med, Collaborating Ctr, Joanna Briggs Inst, 11 Beisanhuandonglu, Beijing, Peoples R China.
   [Mai, Qiulu; Li, Xuejing; Yang, Dan; Zhang, Xiaoyan; Peng, Ke; Hao, Yufang] Beijing Univ Chinese Med, Best Practice Spotlight Org, 11 Beisanhuandonglu, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine
RP Hao, YF (corresponding author), Beijing Univ Chinese Med, Sch Nursing, 11 Beisanhuandonglu, Beijing, Peoples R China.; Hao, YF (corresponding author), Beijing Univ Chinese Med, Collaborating Ctr, Joanna Briggs Inst, 11 Beisanhuandonglu, Beijing, Peoples R China.; Hao, YF (corresponding author), Beijing Univ Chinese Med, Best Practice Spotlight Org, 11 Beisanhuandonglu, Beijing, Peoples R China.
EM bucmnursing@163.com
RI Hao, Yufang/R-6580-2018
FU Major special funding of Bei-jing University of Traditional Chinese
   Medicine [2020-JYB-ZDGG-075]
FX Financial support This systematic review was funded by Major special
   funding of Bei-jing University of Traditional Chinese Medicine
   (2020-JYB-ZDGG-075) . The funder had no role in study design, data
   collection and analysis, interpretation of data, preparation of the
   manuscript, or decision to publish.
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U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD APR
PY 2022
VL 51
AR 102120
DI 10.1016/j.eujim.2022.102120
EA APR 2022
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 1C0PA
UT WOS:000792829700002
DA 2026-01-16
ER

PT J
AU Ryu, HK
   Baek, YH
   Park, YC
   Seo, BK
AF Ryu, Hee Kyoung
   Baek, Yong-Hyeon
   Park, Yeon-Cheol
   Seo, Byung-Kwan
TI Current Studies of Acupuncture in Cancer-Induced Bone Pain Animal Models
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID RAT MODEL; MANAGEMENT; MECHANISMS; EXPRESSION; HYPERALGESIA
AB Acupuncture is generally accepted as a safe and harmless treatment option for alleviating pain. To explore the pain mechanism, numerous animal models have been developed to simulate specific human pain conditions, including cancer-induced bone pain (CIBP). In this study, we analyzed the current research methodology of acupuncture for the treatment of CIBP. We electronically searched the PubMed database for animal studies published from 2000 onward using these search terms: (bone cancer OR cancer) AND (pain OR analgesia) AND (acupuncture OR pharmacopuncture OR bee venom). We selected articles that described cancer pain in animal models. We analyzed the methods used to induce cancer pain and the outcome measures used to assess the effects of acupuncture on CIBP in animal models. We reviewed articles that met our inclusion criteria. Injection of mammary cancer cells into the cavity of the tibia was the most frequently used method for inducing CIBP in the animal models. Among the eight selected studies, five studies demonstrated the effects of electroacupuncture on CIBP. The effects of acupuncture were assessed by measuring pain-related behavior. Future researches will be needed to ascertain the effectiveness of acupuncture for treating CIBP and to explore the specific mechanism of CIBP in animal models.
C1 [Ryu, Hee Kyoung; Baek, Yong-Hyeon; Park, Yeon-Cheol; Seo, Byung-Kwan] Kyung Hee Univ Hosp Gangdong, Dept Acupuncture & Moxibust, Seoul 134727, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital
RP Seo, BK (corresponding author), Kyung Hee Univ Hosp Gangdong, Dept Acupuncture & Moxibust, 149 Sangil Dong, Seoul 134727, South Korea.
EM seohbk@hanmail.net
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HI13C0379]
FX This research was supported by a Grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea
   (Grant no.: HI13C0379).
CR [Anonymous], J PHYSIOL SCI
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NR 36
TC 7
Z9 11
U1 1
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 191347
DI 10.1155/2014/191347
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AS4SO
UT WOS:000344267200001
PM 25383081
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Smeester, BA
   Al-Gizawiy, M
   Beitz, AJ
AF Smeester, Branden A.
   Al-Gizawiy, Mona
   Beitz, Alvin J.
TI Effects of Different Electroacupuncture Scheduling Regimens on Murine
   Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of
   Inflammation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID CANCER PAIN; ACUPUNCTURE TREATMENT; ANIMAL-MODELS; EXPRESSION;
   MECHANISMS; COMPLEMENTARY; ONCOLOGY; EDEMA; RATS; ST36
AB Previous studies have shown that electroacupuncture (EA) is able to reduce hyperalgesia in rodent models of persistent pain, but very little is known about the analgesic effects and potential sex differences of different EA treatment regimens. In the present study, we examined the effects of five different EA treatments on tumor-induced hyperalgesia in male and female mice. EA applied to the ST-36 acupoint either twice weekly (EA-2X/3) beginning on postimplantation day (PID) 3 or prophylactically three times prior to implantation produced the most robust and longest lasting antinociceptive effects. EA treatment given once per week beginning at PID 7 only produced an antinociceptive effect in female animals. The analgesic effect of EA-2X/3 began earlier in males, but lasted longer in females indicating sex differences in EA. We further demonstrate that EA-2X/3 elicits a marked decrease in tumor-associated inflammation as evidenced by a significant reduction in tumor-associated neutrophils at PID 7. Moreover, EA-2X/3 produced a significant reduction in tumor-associated PGE(2) as measured in microperfusate samples. Collectively, these data provide evidence that EA-2X/3 treatment reduces tumor-induced hyperalgesia, which is associated with a decrease in tumor-associated inflammation and PGE(2) concentration at the tumor site suggesting possible mechanisms by which EA reduces tumor nociception.
C1 [Smeester, Branden A.; Beitz, Alvin J.] Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, St Paul, MN 55108 USA.
   [Al-Gizawiy, Mona] Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Medical College of Wisconsin
RP Beitz, AJ (corresponding author), Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, St Paul, MN 55108 USA.
EM beitz001@umn.edu
RI ; Smeester, Branden/E-7655-2013
OI Beitz, Alvin/0000-0002-2640-2628; 
FU National Cancer Institute at NIH [5R01/CA084233]
FX The authors would like to thank Elaine O'Brien and Heather Bainter for
   their technical assistance. This study was supported by a Grant
   (5R01/CA084233) from the National Cancer Institute at NIH.
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NR 69
TC 15
Z9 17
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 671386
DI 10.1155/2012/671386
PG 16
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 061QH
UT WOS:000312862500001
PM 23320035
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Ng, SSM
   Leung, WW
   Mak, TWC
   Hon, SSF
   Li, JCM
   Wong, CYN
   Tsoi, KKF
   Lee, JFY
AF Ng, Simon S. M.
   Leung, Wing Wa
   Mak, Tony W. C.
   Hon, Sophie S. F.
   Li, Jimmy C. M.
   Wong, Cherry Y. N.
   Tsoi, Kelvin K. F.
   Lee, Janet F. Y.
TI Electroacupuncture Reduces Duration of Postoperative Ileus After
   Laparoscopic Surgery for Colorectal Cancer
SO GASTROENTEROLOGY
LA English
DT Article
DE Colon Cancer; Therapy; Recovery Time; Gastrointestinal Motility
ID FUNCTIONAL GASTROINTESTINAL DISORDERS; RANDOMIZED CONTROLLED-TRIAL;
   COLONIC SURGERY; CONSCIOUS RATS; ACUPUNCTURE; PLACEBO; PAIN
AB BACKGROUND & AIMS: We investigated the efficacy of electroacupuncture in reducing the duration of postoperative ileus and hospital stay after laparoscopic surgery for colorectal cancer. METHODS: We performed a prospective study of 165 patients undergoing elective laparoscopic surgery for colonic and upper rectal cancer, enrolled from October 2008 to October 2010. Patients were assigned randomly to groups that received electroacupuncture (n = 55) or sham acupuncture (n = 55), once daily from postoperative days 1 - 4, or no acupuncture (n = 55). The acupoints Zusanli, Sanyinjiao, Hegu, and Zhigou were used. The primary outcome was time to defecation. Secondary outcomes included postoperative analgesic requirement, time to ambulation, and length of hospital stay. RESULTS: Patients who received electroacupuncture had a shorter time to defecation than patients who received no acupuncture (85.9 +/- 36.1 vs 122.1 +/- 53.5 h; P < .001) and length of hospital stay (6.5 +/- 2.2 vs 8.5 +/- 4.8 days; P = .007). Patients who received electroacupuncture also had a shorter time to defecation than patients who received sham acupuncture (85.9 +/- 36.1 vs 107.5 +/- 46.2 h; P = .007). Electroacupuncture was more effective than no or sham acupuncture in reducing postoperative analgesic requirement and time to ambulation. In multiple linear regression analysis, an absence of complications and electroacupuncture were associated with a shorter duration of postoperative ileus and hospital stay after the surgery. CONCLUSIONS: In a clinical trial, electroacupuncture reduced the duration of postoperative ileus, time to ambulation, and postoperative analgesic requirement, compared with no or sham acupuncture, after laparoscopic surgery for colorectal cancer. ClinicalTrials.gov number, NCT00464425.
C1 [Ng, Simon S. M.; Leung, Wing Wa; Mak, Tony W. C.; Hon, Sophie S. F.; Li, Jimmy C. M.; Wong, Cherry Y. N.; Tsoi, Kelvin K. F.; Lee, Janet F. Y.] Chinese Univ Hong Kong, Prince Wales Hosp, Div Colorectal Surg, Dept Surg, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital Hong Kong
RP Ng, SSM (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Div Colorectal Surg, Dept Surg, Room 64045,4-F Clin Sci Bldg, Shatin, Hong Kong, Peoples R China.
EM simonng@surgery.cuhk.edu.hk
RI Mak, Tony/M-1310-2018; Ng, Simon/M-1219-2018
FU Health and Health Services Research Fund, Food and Health Bureau, Hong
   Kong SAR Government [06070371]
FX Supported by the Health and Health Services Research Fund (reference
   number 06070371), Food and Health Bureau, Hong Kong SAR Government.
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NR 30
TC 135
Z9 169
U1 3
U2 83
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD FEB
PY 2013
VL 144
IS 2
BP 307
EP +
DI 10.1053/j.gastro.2012.10.050
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 086VL
UT WOS:000314716300024
PM 23142625
DA 2026-01-16
ER

PT J
AU Zhou, XC
   Zhang, JY
   Jiang, L
   Zhang, SK
   Gu, YH
   Tang, JY
   Pu, T
   Quan, XM
   Chi, H
   Huang, SK
AF Zhou, Xuancheng
   Zhang, Jieying
   Jiang, Lai
   Zhang, Shengke
   Gu, Yuheng
   Tang, Jingyi
   Pu, Tong
   Quan, Xiaomin
   Chi, Hao
   Huang, Shangke
TI Therapeutic efficacy of acupuncture point stimulation for stomach cancer
   pain: a systematic review and meta-analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE acupuncture point stimulation; stomach cancer pain; therapeutic
   efficacy; traditional Chinese medicine; meta-analysis
ID MOXIBUSTION
AB Purpose: In recent years, traditional Chinese medicine has received widespread attention in the field of cancer pain treatment. This meta-analysis is the first to evaluate the effectiveness and safety of acupuncture point stimulation in the treatment of stomach cancer pain. Methods: For this systematic review and meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Embase, WANFANG, China National Knowledge Infrastructure (CNKI), and Chinese Journal of Science and Technology (VIP) databases as well as forward and backward citations to studies published between database creation to July 27, 2023. All randomized controlled trials (RCTs) on acupuncture point stimulation for the treatment of patients with stomach cancer pain were included without language restrictions. We assessed all outcome indicators of the included trials. The evidence from the randomized controlled trials was synthesized as the standardized mean difference (SMD) of symptom change. The quality of the evidence was assessed using the Cochrane Risk of Bias tool. This study is registered on PROSPERO under the number CRD42023457341. Results: Eleven RCTs were included. The study included 768 patients, split into 2 groups: acupuncture point stimulation treatment group (n = 406), medication control group (n = 372). The results showed that treatment was more effective in the acupuncture point stimulation treatment group than in the medication control group (efficacy rate, RR = 1.63, 95% CI 1.37 to 1.94, p < 0.00001), decreasing in NRS score was greater in acupuncture point stimulation treatment group than in the medication control group (SMD = -1.30, 95% CI -1.96 to -0.63, p < 0.001). Systematic Review Registration: https://clinicaltrials.gov/, identifier CRD42023457341.
C1 [Zhou, Xuancheng; Jiang, Lai; Zhang, Shengke; Gu, Yuheng; Tang, Jingyi; Chi, Hao] Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China.
   [Zhang, Jieying] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.
   [Zhang, Jieying] Natl Clin Res Ctr, Chinese Med Acupuncture & Moxibust, Tianjin, Peoples R China.
   [Pu, Tong] Hunan Univ Chinese Med, Coll Acupuncture & Tuina & Rehabil, Changsha, Peoples R China.
   [Quan, Xiaomin] Beijing Chinese Med Second Affiliated Dong Fang Ho, Dept Oncol, Beijing, Peoples R China.
   [Huang, Shangke] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China.
C3 Southwest Medical University; Tianjin University of Traditional Chinese
   Medicine; Hunan University of Chinese Medicine; Southwest Medical
   University
RP Chi, H (corresponding author), Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China.; Huang, SK (corresponding author), Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China.
EM chihao7511@gmail.com; huangshangke001@swmu.edu.cn
RI Zhou, Xuancheng/KPB-5221-2024; huang, shangke/KIK-5715-2024; Pu,
   Tong/KLD-2136-2024; Zhang, Jieying/KJL-6447-2024; Zhang,
   Shengke/JGD-7874-2023; Chi, Hao/GOE-4749-2022; gu, yuheng/OAJ-0627-2025;
   Jiang, Lai/JGD-8172-2023
OI Zhou, Xuancheng/0009-0003-0700-9382; Pu, Tong/0009-0004-0060-0070; Chi,
   Hao/0000-0002-5210-0770; 
FU Doctoral Startup Fund of the Affiliated Hospital of Southwest Medical
   University [19025]; Innovation and Entrepreneurship Training Program of
   Southwest Medical University [2023393]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project is
   supported by the Doctoral Startup Fund of the Affiliated Hospital of
   Southwest Medical University (No. 19025) and Innovation and
   Entrepreneurship Training Program of Southwest Medical University (No.
   2023393).
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NR 48
TC 12
Z9 14
U1 6
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD APR 4
PY 2024
VL 15
AR 1334657
DI 10.3389/fneur.2024.1334657
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA OB2P1
UT WOS:001204737800001
PM 38638316
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Magee, DJ
   Schutzer-Weissmann, J
   Pereira, EAC
   Brown, MRD
AF Magee, David J.
   Schutzer-Weissmann, John
   Pereira, Erlick A. C.
   Brown, Matthew R. D.
TI Neuromodulation techniques for cancer pain management
SO CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
LA English
DT Review
DE cancer; intrathecal drug delivery; neuromodulation; pain
ID SPINAL-CORD STIMULATION; INTRATHECAL MORPHINE INFUSION; PERIPHERAL-NERVE
   STIMULATION; BREAST-CANCER; CONTROLLED-TRIAL; DELIVERY-SYSTEM; OPIOID
   THERAPY; ACUPUNCTURE; ELECTROACUPUNCTURE; MULTICENTER
AB Purpose of review Advanced pain management techniques may be indicated in 5-15% of cancer patients. Despite this, a recent review identified that, over the course of 1 year in England, only 458 patients received a procedure intended to provide analgesia and only 30 patients had intrathecal drug delivery (ITDD) devices implanted. This article describes the emerging evidence for ITDD in cancer pain and provides a narrative review of other neuromodulatory techniques (including spinal cord stimulation, peripheral nerve stimulation and acupuncture), approaches that might be employed to address this area of significant unmet clinical need. Recent findings Numerous studies have been published within the last year reporting positive outcomes associated with ITDD in cancer pain management. Neuromodulation represents an important strategy in the management of persistent pain. Whilst the nonmalignant pain evidence-base is rapidly growing, it remains sparse for cancer pain management. The growing cohort of cancer survivors may significantly benefit from neuromodulatory techniques. ITDD and other neuromodulatory techniques for cancer pain management appear underutilised in the UK and offer the prospect of better treatment for cancer patients with refractory pain or intolerable side-effects from systemic analgesics.
C1 [Magee, David J.] Inst Canc Res, Div Canc Biol, Signalling & Canc Metab Team, London, England.
   [Magee, David J.; Schutzer-Weissmann, John; Brown, Matthew R. D.] Royal Marsden Hosp, Pain Med Dept, London, England.
   [Pereira, Erlick A. C.] St Georges Univ London, Neurosci Res Ctr, Mol & Clin Sci Inst, London, England.
   [Pereira, Erlick A. C.] St Georges Univ Hosp, Dept Neurosurg, London, England.
   [Brown, Matthew R. D.] Inst Canc Res, Targeted Approaches Canc Pain Grp, London, England.
C3 Royal Marsden NHS Foundation Trust; University of London; Institute of
   Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of
   London; King's College London; City St Georges, University of London;
   City St Georges, University of London; University of London; Institute
   of Cancer Research - UK; Royal Marsden NHS Foundation Trust
RP Magee, DJ (corresponding author), Royal Marsden Hosp, Pain Management Dept, Fulham Rd, London SW3 6JJ, England.
EM davidmagee@nhs.net
RI Pereira, Erlick/AAB-5335-2020
OI Brown, Matthew/0000-0002-4520-6462
FU NHS; NIHR
FX NHS funding to the Royal Marsden/Institute of Cancer Research NIHR
   Biomedical Research Centre. Additionally, DM receives NIHR funding as an
   NIHR Academy Member at the Biomedical Research Centre at The Royal
   Marsden and the Institute of Cancer Research.
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NR 64
TC 10
Z9 10
U1 3
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1751-4258
EI 1751-4266
J9 CURR OPIN SUPPORT PA
JI Curr. Opin Support Palliat. Car.
PD JUN
PY 2021
VL 15
IS 2
BP 77
EP 83
DI 10.1097/SPC.0000000000000549
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA ST1XK
UT WOS:000662243900002
PM 33843762
DA 2026-01-16
ER

PT J
AU Li, Y
   Hong, E
   Ye, WG
   You, JY
AF Li, Yan
   Hong, Ensi
   Ye, Wenguo
   You, Jianyu
TI Moxibustion as an Adjuvant Therapy for Cancer Pain: A Systematic Review
   and Meta-Analysis
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE moxibustion; cancer pain; systematic review; meta-analysis
ID INFLAMMATORY VISCERAL PAIN; PHARMACOLOGICAL MANAGEMENT; SURVIVORS
AB Purpose: Pain is one of the most common and feared symptoms among cancer patients. Unrelieved pain denies patients comfort and greatly affects their overall quality of life. Moxibustion is commonly used to manage chronic pain. However, its efficacy on cancer pain remains inconclusive. This study aimed to evaluate the efficacy of moxibustion for cancer pain.Methods: We searched seven databases to obtain articles about moxibustion combined with pharmacotherapy for cancer pain published before November 2022. All data extraction was carried out independently by two investigators. RevMan 5.4 software was used for data analysis.Results: A total of ten trials involving 999 cases were included. The results of the meta-analysis revealed that moxibustion combined with pharmacotherapy was significantly better than drug therapy alone in improving pain relief rate (RR =1.16, 95% CI = [1.04, 1.30], P = 0.01), reducing pain scores (SMD = -1.43, 95% CI = [-2.09, -0.77], P < 0.0001), Shortening the onset of analgesia (MD = -12.07, 95% CI = [-12.91, -11.22], P < 0.00001), prolonging the duration of analgesia (MD = 3.69, 95% CI = [3.21, 4.18], P < 0.00001), and improving quality of life (SMD = 2.48, 95% CI = [0.67, 4.29], P = 0.007). In addition, moxibustion combined with pharmacotherapy can effectively reduce adverse reactions of drugs (RR =0.35, 95% CI = [0.21, 0.57], P < 0.0001).Conclusion: The evidence in this review supports moxibustion as an effective adjuvant therapy for cancer pain management. However, high-quality RCTs are needed to further confirm these findings. Registration Number: PROSPERO CRD42022370942.
C1 [Li, Yan; Hong, Ensi; You, Jianyu] Jiangxi Univ Chinese Med, Nanchang, Peoples R China.
   [Hong, Ensi; Ye, Wenguo] Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Peoples R China.
   [Ye, Wenguo] Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.
   [You, Jianyu] Jiangxi Univ Chinese Med, Nanchang, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; Jiangxi University of Traditional
   Chinese Medicine; Jiangxi University of Traditional Chinese Medicine
RP Ye, WG (corresponding author), Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.; You, JY (corresponding author), Jiangxi Univ Chinese Med, Nanchang, Jiangxi, Peoples R China.
EM 648957697@qq.com; youjytcm@163.com
OI You, Jianyu/0000-0002-4318-292X
FU National Administration of Traditional Chinese Medicine Cultivation
   Discipline Construction -Science of Acupuncture [1241800102]
FX This work was supported by the National Administration of Traditional
   Chinese Medicine Cultivation Discipline Construction -Science of
   Acupuncture and Moxibustion (1241800102) .
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NR 54
TC 11
Z9 12
U1 2
U2 23
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 515
EP 525
DI 10.2147/JPR.S396696
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9C1JC
UT WOS:000935181100001
PM 36824500
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yeh, CH
   Chien, LC
   Chiang, YC
   Ren, DX
   Suen, LKP
AF Yeh, Chao Hsing
   Chien, Lung-Chang
   Chiang, Yi Chien
   Ren, Dianxu
   Suen, Lorna Kwai-Ping
TI Auricular Point Acupressure as an Adjunct Analgesic Treatment for Cancer
   Patients: A Feasibility Study
SO PAIN MANAGEMENT NURSING
LA English
DT Article
ID QUALITY-OF-LIFE; COLON-CANCER; PAIN; ACUPUNCTURE; ONCOLOGY; TRIAL;
   PREVALENCE; IMPACT; SCALE; LUNG
AB This study aimed (1) to examine the feasibility of an auricular point acupressure (APA) research protocol in terms of recruitment and for the assessment and management of pain and (2) to examine the potential APA analgesic effects for cancer patients. This study was a repeated-measures one-group design. Participants were recruited from the cancer center follow-up clinic affiliated with a large university hospital in the northeastern United States. Participants included 50 patients aged 55-87 years with a diagnosis of cancer. Participants received 7 days of APA treatment for their pain. After appropriate acupoints were identified, vaccaria seeds were carefully taped onto each selected auricular point on each ear. The study recruitment and retention rates were 92% and 91%, respectively. Importantly, the study found preliminary evidence for the analgesic effects of APA for cancer pain management. For example, by the end of the 7-day study, APA reduced pain intensity more than 55% for "worst pain" and about 57% for "average pain" and "pain intensity." Moreover, the use of pain medication was reduced during the APA treatment (e.g., 78% of patients [n = 39] took less pain medication than before the treatment). APA appears to be highly acceptable to patients with cancer-related pain. However, without a placebo control, we cannot draw conclusive evidence for the analgesic effect of APA for cancer patients. A sham group must be added to future studies to differentiate the true effects of APA from the possible psychological effects of the APA treatment. (C) 2015 by the American Society for Pain Management Nursing
C1 [Yeh, Chao Hsing; Ren, Dianxu] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
   [Chien, Lung-Chang] Univ Texas Sch Publ Hlth San Antonio, Div Biostat, San Antonio, TX USA.
   [Chien, Lung-Chang] Univ Texas Hlth Sci Ctr San Antonio, Res Adv Community Hlth Ctr, San Antonio, TX 78229 USA.
   [Chiang, Yi Chien] Chang Gung Univ Sci & Technol, Dept Nursing, Kwei San 33302, Tao Yuen, Taiwan.
   [Suen, Lorna Kwai-Ping] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Texas System; University of Texas at San
   Antonio; Chang Gung University of Science & Technology; Hong Kong
   Polytechnic University
RP Chiang, YC (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, 261 Wen Hwa 1 Rd, Kwei San 33302, Tao Yuen, Taiwan.
EM ycchiang@gw.cgust.edu.tw
RI Chiang, Yi-Chien/HTQ-5271-2023; Suen, Lorna/F-5077-2014
OI Chiang, Yi-Chien/0000-0003-2835-898X; Suen, Lorna/0000-0002-0126-6674
FU American Cancer Society [124638-PEP-13-237-01-PCSM]; Center for Research
   and Evaluation (CRE) Pilot/Feasibility Study Program, University of
   Pittsburgh (Pitt), School of Nursing (SoN); Chang Gung Memorial Hospital
   in Taiwan [BMRPA63]
FX The authors would like to thank Dr. Jay for her thoughtful review and
   comments during the preparation for this manuscript and Dr. Huang for
   her suggestions in the development of the intervention protocol used in
   this study. This study was supported by Pilot and Exploratory Projects
   in Palliative Care of Cancer Patients and their Families (grant number:
   124638-PEP-13-237-01-PCSM) by the American Cancer Society and the Center
   for Research and Evaluation (CRE) Pilot/Feasibility Study Program,
   University of Pittsburgh (Pitt), School of Nursing (SoN), and a grant to
   Dr. Chiang from Chang Gung Memorial Hospital (Grant number: BMRPA63) in
   Taiwan. The authors also thank Brian Greene in the Pitt SoN CRE for his
   editorial support.
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NR 36
TC 20
Z9 28
U1 2
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD JUN
PY 2015
VL 16
IS 3
BP 285
EP 293
DI 10.1016/j.pmn.2014.08.005
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CJ1AD
UT WOS:000355212500016
PM 25439120
DA 2026-01-16
ER

PT J
AU Lux, S
   Lobos, N
   Lespay-Rebolledo, C
   Salas-Huenuleo, E
   Kogan, MJ
   Flores, C
   Pinto, M
   Hernandez, A
   Pelissier, T
   Constandil, L
AF Lux, Sebastian
   Lobos, Nicolas
   Lespay-Rebolledo, Carolyne
   Salas-Huenuleo, Edison
   Kogan, Marcelo J.
   Flores, Christian
   Pinto, Mauricio
   Hernandez, Alejandro
   Pelissier, Teresa
   Constandil, Luis
TI The antinociceptive effect of resveratrol in bone cancer pain is
   inhibited by the Silent Information Regulator 1 inhibitor selisistat
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE cancer pain; mice; resveratrol; selisistat; Silent Information Regulator
   1
ID SUPPRESSES NEUROINFLAMMATION; SKELETAL DESTRUCTION; NEUROPATHIC PAIN;
   MURINE MODEL; SPINAL-CORD; HYPERALGESIA; ACTIVATION; MANAGEMENT; TUMOR;
   REORGANIZATION
AB Objectives To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat. Methods The femoral intercondylar bone of BALB/c mice was injected with 1 000 000 BJ3Z cancer cells. Bone resorption and tumour mass growth (measured by in vivo X-ray and fluorescence imaging), as well as mechanical nociceptive thresholds (von Frey device) and dynamic functionality (rotarod machine), were evaluated during the following 4 weeks. Acute resveratrol (100 mg/kg i.p.) and/or selisistat (10 mg/kg s.c.) were administered on day 14. Chronic resveratrol (100 mg/kg i.p., daily) and/or selisistat (0.5 mu g/h s.c., Alzet pump) were administered between days 14 and 20. Key findings Tumour growth gradually incremented until day 31, while mechanical hyperalgesia started on day 3 after cancer cell injection. Acute resveratrol increased the mechanical threshold of pain (peaking at 1.5 h), while the dynamic functionality decreased. Chronic resveratrol produced a sustained antinociceptive effect on mechanical hyperalgesia and improved the loss of dynamic functionality induced by the bone cancer tumour. Selisistat prevented all the effects of resveratrol. Conclusions Acute and chronic resveratrol induces antinociceptive effect in the model of metastatic osseous oncological pain, an effect that would be mediated by SIRT1 molecular signalling.
C1 [Lux, Sebastian; Lobos, Nicolas; Flores, Christian; Hernandez, Alejandro; Pelissier, Teresa; Constandil, Luis] Univ Santiago Chile, Fac Chem & Biol, Dept Biol, Lab Neurobiol, Santiago 9170022, Chile.
   [Lespay-Rebolledo, Carolyne; Pelissier, Teresa] Univ Chile, Program Mol & Clin Pharmacol, Fac Med, Inst Biomed Sci, Santiago, Chile.
   [Salas-Huenuleo, Edison; Kogan, Marcelo J.] Univ Chile, Fac Chem & Pharmaceut Sci, Dept Pharmacol & Toxicol Chem, Santiago, Chile.
   [Salas-Huenuleo, Edison; Kogan, Marcelo J.] Univ Santiago Chile, Fac Chem & Biol, Adv Ctr Chron Dis ACCDiS, Santiago, Chile.
   [Pinto, Mauricio] Univ Santiago Chile, Fac Chem & Biol, Dept Biol, Lab Immunol Reprod, Santiago, Chile.
   [Constandil, Luis] Ctr Dev Nanosci & Nanotechnol CEDENNA, Santiago, Chile.
C3 Universidad de Santiago de Chile; Universidad de Chile; Universidad de
   Chile; Universidad de Santiago de Chile; Universidad de Santiago de
   Chile
RP Constandil, L (corresponding author), Univ Santiago Chile, Fac Chem & Biol, Dept Biol, Lab Neurobiol, Santiago 9170022, Chile.
EM luis.constandil@usach.cl
RI ; Pinto, Mauricio P/HCH-2145-2022; Constandil, Luis/ADD-3853-2022;
   Hernandez, Alejano/M-4796-2019; Kogan, Marcelo/I-2868-2013;
   Salas-Huenuleo, Edison/AAF-6987-2019
OI LESPAY-REBOLLEDO, CAROLYNE/0000-0002-1851-9359; Pinto, Mauricio
   P/0000-0003-2484-8033; Constandil, Luis/0000-0002-2504-0119; Hernandez,
   Alejano/0000-0001-9222-6522; Kogan, Marcelo/0000-0003-0608-5087;
   Salas-Huenuleo, Edison/0000-0003-4355-5252
FU Centers of Excellence with Basal/Conicyt financing, CEDENNA [FB0807];
   Fondecyt [1181622]; Fondap [15130011]; Conicyt [21140171]
FX This work was supported by the Centers of Excellence with Basal/Conicyt
   financing, CEDENNA (grant FB0807), Fondecyt Project (grant 1181622),
   Fondap Project (grant 15130011) and Conicyt Fellowship (grant 21140171).
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NR 54
TC 13
Z9 14
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD MAY
PY 2019
VL 71
IS 5
BP 816
EP 825
DI 10.1111/jphp.13064
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HU1EL
UT WOS:000465015000010
PM 30592048
OA Bronze
DA 2026-01-16
ER

PT J
AU Paley, CA
   Johnson, MI
   Tashani, OA
   Bagnall, AM
AF Paley, Carole A.
   Johnson, Mark I.
   Tashani, Osama A.
   Bagnall, Anne-Marie
TI Acupuncture for cancer pain in adults
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID BONE PAIN; MANAGEMENT; METAANALYSIS; ELECTROACUPUNCTURE; OSTEOARTHRITIS;
   TRIALS; NECK
AB Background
   Forty percent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief. It has been claimed that acupuncture has a role in management of cancer pain and guidelines exist for treatment of cancer pain with acupuncture.
   Objectives
   To evaluate efficacy of acupuncture for relief of cancer-related pain in adults.
   Search strategy
   CENTRAL, MEDLINE, EMBASE, PsycINFO, AMED, and SPORTDiscus were searched up to November 2010 including non-English language papers.
   Selection criteria
   Randomised controlled trials (RCTs) evaluating any type of invasive acupuncture for pain directly related to cancer in adults of 18 years or over.
   Data collection and analysis
   It was planned to pool data to provide an overall measure of effect and to calculate the number needed to treat to benefit, but this was not possible due to heterogeneity. Two review authors (CP, OT) independently extracted data adding it to data extraction sheets. Quality scores were given to studies. Data sheets were compared and discussed with a third review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT and MJ.
   Main results
   Three RCTs (204 participants) were included. One high quality study investigated the effect of auricular acupuncture compared with auricular acupuncture at 'placebo' points and with non-invasive vaccaria ear seeds attached at 'placebo' points. Participants in two acupuncture groups were blinded but blinding wasn't possible in the ear seeds group because seeds were attached using tape. This may have biased results in favour of acupuncture groups. Participants in the real acupuncture group had lower pain scores at two month follow-up than either the placebo or ear seeds group.
   There was high risk of bias in two studies because of low methodological quality. One study comparing acupuncture with medication concluded that both methods were effective in controlling pain, although acupuncture was the most effective. The second study compared acupuncture, point-injection and medication in participants with stomach cancer. Long-term pain relief was reported for both acupuncture and point-injection compared with medication during the last 10 days of treatment. Although both studies have positive results in favour of acupuncture they should be viewed with caution due to methodological limitations, small sample sizes, poor reporting and inadequate analysis.
   Authors' conclusions
   There is insufficient evidence to judge whether acupuncture is effective in treating cancer pain in adults.
C1 [Paley, Carole A.] Airedale NHS Trust, Res & Effectiveness Dept, Airedale Gen Hosp, Keighley BD20 6TD, W Yorkshire, England.
   [Johnson, Mark I.; Tashani, Osama A.; Bagnall, Anne-Marie] Leeds Metropolitan Univ, Fac Hlth, Leeds LS1 3HE, W Yorkshire, England.
C3 Leeds Beckett University
RP Paley, CA (corresponding author), Airedale NHS Trust, Res & Effectiveness Dept, Airedale Gen Hosp, Keighley BD20 6TD, W Yorkshire, England.
EM biodynamics.physiotherapy@tesco.net
RI ; Paley, Carole Anne/AAM-2469-2020
OI Bagnall, Anne-Marie/0000-0003-1512-0833; Paley, Carole
   Anne/0000-0002-6335-2666; Tashani, Osama/0000-0002-1998-4981
FU Leeds Metropolitan University, UK
FX Leeds Metropolitan University, UK. Academic support for the project.
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NR 69
TC 56
Z9 60
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2011
IS 1
AR CD007753
DI 10.1002/14651858.CD007753.pub2
PG 27
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 708VU
UT WOS:000286393200018
PM 21249694
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Bettini, E
   Idiokitas, R
   Mahmood, L
   Jacobs, S
   Steinhorn, D
AF Bettini, Elizabeth
   Idiokitas, Risi
   Mahmood, Laila
   Jacobs, Shana
   Steinhorn, David
TI Safety and Acceptance of Acupuncture and Acupressure in Children,
   Adolescents, and Young Adults Undergoing Hematopoietic Stem Cell
   Transplant
SO CANCER NURSING
LA English
DT Article
DE Acupressure; Acupuncture; Bone marrow transplant; Hematopoietic stem
   cell transplant; Pediatric Hematology Oncology
ID CHEMOTHERAPY-INDUCED NAUSEA; PEDIATRIC-PATIENTS; REDUCTION; MEDICINE;
   BURDEN; CARE
AB BackgroundHematopoietic stem cell transplant (HSCT) is associated with significant morbidity and high symptom burden including mucositis pain, nausea, and vomiting. There is little documentation in the literature regarding acupuncture or acupressure for children undergoing HSCT.ObjectiveThe purpose of this study was to determine the safety and acceptance of acupuncture and acupressure in children undergoing HSCT in a large tertiary care children's hospital.MethodsThis is a descriptive retrospective study that evaluated 80 admissions to the HSCT unit over a 24-month period. Every child admitted for HSCT was offered acupuncture or acupressure as part of their care.ResultsOf 80 patients, 46 were male patients (ages range, 0-32 years; mean, 8 years). Diagnoses include leukemia/lymphoma, sickle cell disease, aplastic anemia, neuroblastoma, and other metabolic, other solid tumor, or other hematologic disorders. Both allogenic and autologous were represented. Sixty-six patients (82.5%) agreed to treatment with acupuncture, acupressure, or both. There were no adverse effects or safety concerns noted. Symptoms addressed by acupuncture or acupressure included pain from mucositis, nausea, constipation, diarrhea, anxiety, insomnia, and general wellness or healing.ConclusionThis study demonstrates that acupuncture and acupressure are well accepted by children and their families admitted for HSCT and are safe even when performed in the first 4 weeks following transplant when the patient is likely to have thrombocytopenia.Implications for PracticeThese findings suggest that there may be more therapies for patients undergoing HSCT to help with symptom control.
C1 [Bettini, Elizabeth; Idiokitas, Risi; Mahmood, Laila; Jacobs, Shana] Childrens Natl Hosp, Palliat Care, 111 Michigan Ave NW, Washington, DC 20010 USA.
   [Steinhorn, David] Capital Caring Hosp, Falls Church, VA USA.
C3 Children's National Health System
RP Bettini, E (corresponding author), Childrens Natl Hosp, Palliat Care, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM ebettini@childrensnational.org; Ridiokitas@childrensnational.org;
   Lmahmood@childrensnational.org; ssjacobs@childrensnational.org;
   dsteinhorn@capitalcaring.org
RI Steinhorn, David/JHT-1209-2023
OI Steinhorn, David/0000-0002-1081-891X
CR Chokshi SK, 2017, PEDIATR BLOOD CANCER, V64, DOI 10.1002/pbc.26424
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NR 23
TC 3
Z9 4
U1 1
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD MAY-JUN
PY 2023
VL 46
IS 3
BP E204
EP E207
DI 10.1097/NCC.0000000000001135
PG 4
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA E5MQ6
UT WOS:000975985000013
PM 35679148
DA 2026-01-16
ER

PT J
AU You, XL
   Wang, YJ
   Wu, J
   Liu, QH
   Liu, YQ
   Qian, YY
   Chen, J
   Tang, D
   Wang, DR
AF You, Xiaolan
   Wang, Yuanjie
   Wu, Jian
   Liu, Qinghong
   Liu, Yanqing
   Qian, Yayun
   Chen, Jue
   Tang, Dong
   Wang, Daorong
TI Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic
   Postoperative Ileus following Radical Gastrectomy for Gastric Cancer: a
   Randomized Clinical Trial
SO JOURNAL OF CANCER
LA English
DT Article
DE gastric cancer; paralytic postoperative ileus; ST36 acupucture; ST36
   acupoint injection
ID GASTROINTESTINAL MOTILITY DISORDERS; CHEWING GUM; LAPAROSCOPIC SURGERY;
   ENHANCED RECOVERY; RISK-FACTORS; ACUPUNCTURE; CHEMOTHERAPY; SYMPTOMS;
   PATHWAYS; CARE
AB Background: The Zusanli (ST36) acupoint has been associated with treatment of various gastrointestinal conditions. There have been no studies of acupuncture therapy for paralytic postoperative ileus (PPOI).
   Materials and methods: Patients with PPOI following gastrectomy for gastric cancer were randomized to receive ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 1.0 mg neostigmine, ST36 acupuncture alone, or standard therapy. The main outcome was the effectiveness rate for recovery of peristalsis. Secondary outcomes were time to bowel sound recovery, time to first flatus, and time to first defecation. Tertiary outcomes were drug-related adverse events, including abdominal pain, diarrhea, nausea, vomiting, tearing, delirium, seizure, and anxiety.
   Results: ST36 acupoint injection with neostigmine and gluteal intramuscular injection of neostigmine gave a higher rate of peristalsis recovery, and the ST36 acupoint injection group showed significantly higher total effectiveness rate than that of the intramuscular injection group. These interventions gave significantly shorter times to bowel sound recovery, shorter times to first flatus and first defecation compared with ST36 acupuncture and standard post-operative therapy (P < 0.01). ST36 acupoint injection group gave shorter time to bowel sound recovery, shorter time to first flatus and first defecation than those of the intramuscular injection group (P < 0.01). Drug-related adverse events in the intramuscular injection group were more serious than in the ST36 acupoint injection group (P < 0.05).
   Conclusion: ST36 acupoint injection with neostigmine is safe and effective for treatment of PPOI.
C1 [You, Xiaolan; Liu, Yanqing; Qian, Yayun; Chen, Jue] Yangzhou Univ, Med Coll, Dept Integrated Tradit Chinese & Western Med, Yangzhou, Jiangsu, Peoples R China.
   [You, Xiaolan; Wang, Yuanjie; Wu, Jian; Liu, Qinghong] Taizhou Peoples Hosp, Dept Gastrointestinal Surg, Taizhou, Jiangsu, Peoples R China.
   [Tang, Dong; Wang, Daorong] Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Clin Med Coll, Dept Gastrointestinal Surg, Yangzhou 225000, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University
RP Wang, DR (corresponding author), Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Clin Med Coll, Dept Gastrointestinal Surg, Yangzhou 225000, Jiangsu, Peoples R China.
EM wdaorong666@sina.com
RI Tang, Dong/HKF-4903-2023
OI Tang, Dong/0000-0002-2057-2968
FU National Natural Science Foundation of China [81172279, 81572343]
FX This work was supported in part by the National Natural Science
   Foundation of China [grant numbers 81172279, 81572343].
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NR 36
TC 23
Z9 31
U1 2
U2 41
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2018
VL 9
IS 13
BP 2266
EP 2274
DI 10.7150/jca.24767
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GJ3BH
UT WOS:000435149400004
PM 30026821
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, X
   Liang, B
   Xue, DM
   Liang, J
   Zaslawski, C
   Chen, J
AF Yang, Xia
   Liang, Bing
   Xue, Demin
   Liang, Jing
   Zaslawski, Chris
   Chen, Ji
TI Global research trends in acupuncture for cancer pain: A bibliometric
   analysis
SO MEDICINE
LA English
DT Review
DE acupuncture; bibliometric analysis; cancer pain; CiteSpace;
   visualization; VOSviewer
ID INHIBITOR-INDUCED ARTHRALGIA; BREAST-CANCER; ELECTROACUPUNCTURE;
   CHEMOTHERAPY; EXPRESSION; TRIAL
AB Background: In recent years, acupuncture has gained popularity in the management of cancer-related pain (CRP). This study aims to use bibliometric analysis to investigate the historical development, recent hotspots and research trends in this field.Methods: The Web of Science Core Collection database was selected as the data source for this study to retrieve and obtain literature related to acupuncture and CRP. Data analyses were performed with CiteSpace and VOSviewer to conduct the bibliometric analysis.Results: This bibliometric analysis was conducted from 2000 to 2022. A total of 664 publications were included in this work. The number of publications has steadily increased over the last 2 decades. The United States has the largest number of published articles (244 papers), while the People's Republic of China has the highest centrality (0.48). The primary research institutions were Memorial Sloan-Kettering Cancer Center, Kyung Hee University and Beijing University of Chinese Medicine. Mao Jun J. was the most prolific author, while Heather Greenlee was the most cited one. The most productive journal was Integrative Cancer Therapies. The most frequent keywords excluding the search subject were "electroacupuncture," "management," "quality of life," "breast cancer," "Aromatase inhibitor," "neuropathic pain," "mechanisms," and "protocol."Conclusion: This study explored the application value of acupuncture in the management of CRP with bibliometric analysis, offering an intuitive understanding of this topic and revealing the hotspots and research trends.
C1 [Yang, Xia; Liang, Bing] Chengdu Univ Tradit Chinese Med, Basic Med Coll, Chengdu, Peoples R China.
   [Xue, Demin] Chengdu Univ Tradit Chinese Med, Sch Chinese Class, Chengdu, Peoples R China.
   [Liang, Jing; Chen, Ji] Chengdu Univ Tradit Chinese Med, Sch Foreign Languages, Chengdu, Peoples R China.
   [Zaslawski, Chris] Univ Technol Sydney, Fac Sci, Sydney, NSW, Australia.
   [Chen, Ji] Chengdu Univ Tradit Chinese Med, Sch Foreign Languages, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; University of Technology Sydney; Chengdu University of
   Traditional Chinese Medicine
RP Chen, J (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Foreign Languages, Chengdu 611137, Peoples R China.
EM tyr_yang@126.com; drliangjing@163.com; 2679214114@qq.com;
   drliangjing@163.com; Chris.Zaslawski@uts.edu.au; jeanelle_chin@126.com
OI Yang, Xia/0000-0002-1423-2270; liang, bing/0000-0003-4175-7870
FU National Social Science Fund of China [19XXW005]; Key R&D Programs of
   Sichuan Provincial Department of Science and Technology [2018SZ0072]
FX This study was supported by the National Social Science Fund of China
   (19XXW005) and Key R&D Programs of Sichuan Provincial Department of
   Science and Technology (2018SZ0072).
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NR 46
TC 1
Z9 1
U1 11
U2 76
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 13
PY 2023
VL 102
IS 41
AR e34739
DI 10.1097/MD.0000000000034739
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U7IO1
UT WOS:001086507200040
PM 37832094
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Escobar, Y
   Margarit, C
   Pérez-Hernández, C
   Quintanar, T
   Virizuela, JA
AF Escobar, Yolanda
   Margarit, Cesar
   Perez-Hernandez, Concepcion
   Quintanar, Teresa
   Virizuela, Juan A.
TI Good practice recommendations to better coordinate the management of
   oncological pain: a Delphi survey
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CANCER-RELATED PAIN; PALLIATIVE CARE; PREVALENCE; BARRIERS; CONTINUITY
AB Treatment of oncological pain is complex and requires a multidisciplinary management approach between oncology services and pain units. Although significant improvements have been achieved in the treatment and overall survival of cancer patients, the management of oncological pain has not followed the same directions. Many patients are not referred to pain units even though they could benefit from it. The purpose of this Delphi survey was to map the current situation in the management of cancer pain, identify barriers and propose recommendations to improve its management by emphasizing the importance of collaboration and coordination between oncology services and pain units. A survey among members with recognized experience in the management of oncology patients and oncological pain was held based on the Delphi method principles. The experts were asked to vote preselected statements on cancer pain management in two rounds and conclusions and recommendations were formulated based on the consensus reached for each statement. Barriers and areas for improvement were identified: need of multidisciplinary management approach, effective communication between oncology services and pain units, timely referral of cancer patients to pain units, training of health care professionals dealing with cancer aspects and identification of those patients that could benefit from a multidisciplinary management of their oncological disease. The experts issued recommendations targeting the identified barriers and areas for improvement by defining the service requirements of hospital and units treating cancer pain patients, establishing referral pathways necessities and adopted measures to improve the care of cancer patients.
C1 [Escobar, Yolanda] Univ Gen Hosp Gregorio Maranon, Med Oncol Serv, Spanish Med Oncol Soc, Madrid, Spain.
   [Margarit, Cesar] Univ Gen Hosp Alicante, Pain Unit, Spanish Pain Soc, Alicante, Spain.
   [Perez-Hernandez, Concepcion] Univ Hosp La Princesa, Pain Unit, Spanish Pain Soc, Madrid, Spain.
   [Quintanar, Teresa] Univ Gen Hosp Elche, Med Oncol Serv, Spanish Med Oncol Soc, Alicante, Spain.
   [Virizuela, Juan A.] Univ Hosp Virgen Macarena, Med Oncol Serv, Spanish Med Oncol Soc, Seville, Spain.
C3 General University Gregorio Maranon Hospital; General University
   Hospital of Alicante; Virgen del Rocio University Hospital; University
   of Sevilla; Hospital Universitario Virgen Macarena
RP Escobar, Y (corresponding author), Univ Gen Hosp Gregorio Maranon, Med Oncol Serv, Spanish Med Oncol Soc, Madrid, Spain.
EM yolandaesco@yahoo.es
OI Quintanar, Teresa/0000-0001-5259-9447
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NR 34
TC 5
Z9 5
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 28
PY 2022
VL 12
IS 1
AR 22459
DI 10.1038/s41598-022-26753-3
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7L1VX
UT WOS:000905762900013
PM 36577791
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU O'Regan, D
   Filshie, J
AF O'Regan, David
   Filshie, Jacqueine
TI Acupuncture and cancer
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Article
DE Acupuncture; Cancer
ID RADIATION-INDUCED XEROSTOMIA; AURICULAR ACUPUNCTURE; DIFFERENT
   FREQUENCIES; POINT STIMULATION; PAIN; ELECTROACUPUNCTURE; ACUPRESSURE;
   NAUSEA; CHEMOTHERAPY; BRAIN
AB Acupuncture has become a popular complementary treatment in oncology, particularly as patients seek non-pharmacological alternatives to provide symptom control. A considerable body of evidence suggests that acupuncture modulates neurological processes to bring about its effects. This basic research is supported by an increasing number of positive clinical studies of varying quality. Lower quality studies have hampered the widespread acceptability of acupuncture, with some deeming the inter-personal skills of the practitioner to be more powerful than the needle or its equivalent. More recent randomised control trials (RCTs) have sought to settle this controversy, with mixed results. The literature was searched to identify, where possible, RCTs involving acupuncture and various common cancer symptoms. A potential role for acupuncture was found in the following cancer symptoms: pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression and insomnia. Acupuncture is safe with minimal side-effects, and is clinically effective for the management of these symptoms. Continuing research using validated methodology is essential. In the interim, health professionals should be open to explore the use of acupuncture with their cancer patients. (C) 2010 Published by Elsevier B.V.
C1 [Filshie, Jacqueine] Royal Marsden Hosp, London SW3 6JJ, England.
   Royal Marsden Hosp, Surrey, England.
C3 Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust
RP Filshie, J (corresponding author), Royal Marsden Hosp, London SW3 6JJ, England.
EM jacqueline.filshie@btinternet.com
RI O'Regan, David/AAV-3178-2020
OI O'Regan, David/0000-0002-3809-022X
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NR 68
TC 55
Z9 65
U1 1
U2 57
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD OCT 28
PY 2010
VL 157
IS 1-2
SI SI
BP 96
EP 100
DI 10.1016/j.autneu.2010.05.001
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 679SX
UT WOS:000284182200017
PM 20605536
DA 2026-01-16
ER

PT J
AU Greenlee, H
   Crew, KD
   Capodice, J
   Awad, D
   Buono, D
   Shi, ZX
   Jeffres, A
   Wyse, S
   Whitman, W
   Trivedi, MS
   Kalinsky, K
   Hershman, DL
AF Greenlee, Heather
   Crew, Katherine D.
   Capodice, Jillian
   Awad, Danielle
   Buono, Donna
   Shi, Zaixing
   Jeffres, Anne
   Wyse, Sharon
   Whitman, Wendy
   Trivedi, Meghna S.
   Kalinsky, Kevin
   Hershman, Dawn L.
TI Randomized sham-controlled pilot trial of weekly electro-acupuncture for
   the prevention of taxane-induced peripheral neuropathy in women with
   early stage breast cancer
SO BREAST CANCER RESEARCH AND TREATMENT
LA English
DT Article
DE Acupuncture; Electro-acupuncture; Breast cancer; Chemotherapy-induced
   peripheral neuropathy; Taxane
ID QUALITY-OF-LIFE; WEEKLY PACLITAXEL; DOUBLE-BLIND; HIGH-RISK;
   CHEMOTHERAPY; ACUPUNCTURE; MANAGEMENT; PAIN; DOXORUBICIN; ONCOLOGY
AB To investigate the effect of electro-acupuncture (EA) as a non-pharmacological intervention to prevent or reduce chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients undergoing chemotherapy of taxane. Women with stage I-III breast cancer scheduled to receive taxane therapy were randomized to receive a standardized protocol of 12 true or sham EA (SEA) weekly treatments concurrent with taxane treatment. Subjects completed the Brief Pain Inventory-Short Form (BPI-SF), Functional Assessment of Cancer Therapy-Taxane neurotoxicity subscale (FACT-NTX), and other assessments at baseline and weeks 6, 12, and 16. A total of 180 subjects were screened, 63 enrolled and 48 completed week 16 assessments. Mean age was 50 with 25 % white, 25 % black, and 43 % Hispanic; 52 % had no prior chemotherapy. At week 12, both groups reported an increase in mean BPI-SF worst pain score, but no mean differences were found between groups (SEA 2.8 vs. EA 2.6, P = .86). By week 16, the SEA group returned to baseline, while the EA group continued to worsen (SEA 1.7 vs. EA 3.4, P = .03). The increase in BPI-SF worst pain score was 1.62 points higher in the EA group than in the SEA group at week 16 (P = .04). In a randomized, sham-controlled trial of EA for prevention of taxane-induced CIPN, there were no differences in pain or neuropathy between groups at week 12. Of concern, subjects on EA had a slower recovery than SEA subjects. Future studies should focus on EA for treatment as opposed to prevention of CIPN.
C1 [Greenlee, Heather; Crew, Katherine D.; Buono, Donna; Shi, Zaixing; Hershman, Dawn L.] Columbia Univ, Mailman Sch Publ Hlth, 722 W 168th St,Room 733, New York, NY 10032 USA.
   [Greenlee, Heather; Crew, Katherine D.; Awad, Danielle; Jeffres, Anne; Wyse, Sharon; Whitman, Wendy; Kalinsky, Kevin; Hershman, Dawn L.] Columbia Univ, Herbert Irving Comprehens Canc Ctr, 722 W 168th St,Room 733, New York, NY 10032 USA.
   [Crew, Katherine D.; Awad, Danielle; Trivedi, Meghna S.; Kalinsky, Kevin; Hershman, Dawn L.] Columbia Univ, Coll Phys & Surg, 722 W 168th St,Room 733, New York, NY 10032 USA.
   [Capodice, Jillian] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Greenlee, Heather] Columbia Univ, 722 W 168th St,Room 733, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University; Icahn
   School of Medicine at Mount Sinai; Columbia University
RP Greenlee, H (corresponding author), Columbia Univ, Mailman Sch Publ Hlth, 722 W 168th St,Room 733, New York, NY 10032 USA.; Greenlee, H (corresponding author), Columbia Univ, Herbert Irving Comprehens Canc Ctr, 722 W 168th St,Room 733, New York, NY 10032 USA.; Greenlee, H (corresponding author), Columbia Univ, 722 W 168th St,Room 733, New York, NY 10032 USA.
EM hg2120@columbia.edu
RI Hershman, Dawn/AAG-2114-2020; Shi, Zaixing/K-7269-2019; Trivedi,
   Meghna/HTS-3052-2023
FU Breast Cancer Research Foundation; National Cancer Institute NCI
   [K23CA141052]
FX Breast Cancer Research Foundation (to DLH), National Cancer Institute
   NCI K23CA141052 (to HG).
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NR 43
TC 95
Z9 110
U1 1
U2 42
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0167-6806
EI 1573-7217
J9 BREAST CANCER RES TR
JI Breast Cancer Res. Treat.
PD APR
PY 2016
VL 156
IS 3
BP 453
EP 464
DI 10.1007/s10549-016-3759-2
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DK1IU
UT WOS:000374666500006
PM 27013473
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Jiang, SH
   Tu, WZ
   Zou, EM
   Hu, J
   Wang, S
   Li, JR
   Wang, WS
   He, R
   Cheng, RD
   Liao, WJ
AF Jiang, Song-he
   Tu, Wen-zhan
   Zou, En-miao
   Hu, Jie
   Wang, Sai
   Li, Jiang-ru
   Wang, Wan-sheng
   He, Rong
   Cheng, Rui-dong
   Liao, Wei-jing
TI Neuroprotective Effects of Different Modalities of Acupuncture on
   Traumatic Spinal Cord Injury in Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FUNCTIONAL RECOVERY; ELECTROACUPUNCTURE; STIMULATION; INFLAMMATION;
   INHIBITION; PAIN
AB Spinal cord injury (SCI) can induce a series of histological, biochemical, and functional changes. Acupuncture is commonly used for SCI patients. Using male rats of spinal cord injury with the New York University (NYU)Impactor, we investigated the response of electroacupuncture ( EA), manual acupuncture ( MA), and transcutaneous acupoint electrical stimulation (TAES)at Shuigou (DU26)and Fengfu (DU16) acupoints to understand the effects and mechanisms of acupuncture in neuroprotection and neuronal function recovery after SCI. Histological study showed a restored neural morphology and an increase in the quantity of neurons after EA, MA, and TAES administrations. Acupuncture's antioxidation effects were demonstrated by alleviation of the post-SCI superoxide dismutase (SOD) activity increase and malondialdehyde (MDA) level decrease. The anti-inflammation effect of acupuncture was shown as the reduced expression of inflammatory cytokines including interleukin-1 beta (IL-1 beta), interleukin-6 ( IL-6), and tumor necrosis factor-alpha (TNF-alpha) when SCI was treated. And the antiapoptosis role was approved by TUNEL staining. Our data confirmed that the role of acupuncture in neuroprotection and dorsal neuronal function recovery after rat SCI, especially, EA stimulating at Shuigou (DU26) and Fengfu (DU16) can greatly promote neuronal function recovery, which may result from antioxidation, anti-inflammation, and antiapoptosis effects of acupuncture.
C1 [Jiang, Song-he; Liao, Wei-jing] Wuhan Univ, Zhongnan Hosp, Dept Phys Med & Rehabil, Wuhan 430072, Hubei, Peoples R China.
   [Tu, Wen-zhan; Zou, En-miao; Hu, Jie; Wang, Sai; Wang, Wan-sheng; He, Rong] Wenzhou Med Univ, Dept Phys Med & Rehabil, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China.
   [Li, Jiang-ru] Zhejiang Hosp, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China.
   [Cheng, Rui-dong] Zhejiang Prov Peoples Hosp, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China.
C3 Wuhan University; Wenzhou Medical University; Hangzhou Medical College;
   Zhejiang Provincial People's Hospital
RP Liao, WJ (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Phys Med & Rehabil, Donghu Rd, Wuhan 430072, Hubei, Peoples R China.
EM weijingliao@sina.com
RI Wang, Wansheng/JQI-4096-2023
FU Natural Science Foundation of Zhejiang province, China [Y12H270010];
   Science and Technical Foundation of Wenzhou City, China [Y20110069]
FX This work was supported by grants, no. Y12H270010, from Natural Science
   Foundation of Zhejiang province, China; and grants, no. Y20110069, from
   Science and Technical Foundation of Wenzhou City, China. Thanks are due
   to Ross W. Davis, Steve A. Barrett, and Melissa A. Walsh from the
   Pacific University, Oregon, USA, who offered the authors some help in
   revising the English expression of this paper. In addition, thanks are
   due to Dr. Wenjie Wei, Dr. Hao Chen, Dr. Liping Gao, and Dr. Dhanesh
   Boodhun for the excellent language improvement of the paper.
CR [Anonymous], Q REV BIOL
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NR 32
TC 42
Z9 52
U1 1
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 431580
DI 10.1155/2014/431580
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AE8DV
UT WOS:000334230400001
PM 24803946
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Paley, CA
   Bennett, MI
   Johnson, MI
AF Paley, Carole A.
   Bennett, Michael I.
   Johnson, Mark I.
TI Acupuncture for Cancer-Induced Bone Pain?
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DORSAL-HORN; AURICULAR ACUPUNCTURE; RAT MODEL; COMPLEMENTARY/ALTERNATIVE
   MEDICINE; BRAIN; ELECTROACUPUNCTURE; STIMULATION; ANALGESIA; MODULATION;
   MECHANISMS
AB Bone pain is the most common type of pain in cancer. Bony metastases are common in advanced cancers, particularly in multiple myeloma, breast, prostate or lung cancer. Current pain-relieving strategies include the use of opioid-based analgesia, bisphosphonates and radiotherapy. Although patients experience some pain relief, these interventions may produce unacceptable side-effects which inevitably affect the quality of life. Acupuncture may represent a potentially valuable adjunct to existing strategies for pain relief and it is known to be relatively free of harmful side-effects. Although acupuncture is used in palliative care settings for all types of cancer pain the evidence-base is sparse and inconclusive and there is very little evidence to show its effectiveness in relieving cancer-induced bone pain (CIBP). The aim of this critical review is to consider the known physiological effects of acupuncture and discuss these in the context of the pathophysiology of malignant bone pain. The aim of future research should be to produce an effective protocol for treating CIBP with acupuncture based on a sound, evidence-based rationale. The physiological mechanisms presented in this review suggest that this is a realistic objective.
C1 [Paley, Carole A.; Johnson, Mark I.] Leeds Metropolitan Univ, Fac Hlth, Leeds LS1 3HE, W Yorkshire, England.
   [Paley, Carole A.] Airedale Dist Gen Hosp, Keighley, W Yorkshire, England.
   [Paley, Carole A.; Bennett, Michael I.; Johnson, Mark I.] Leeds Pallium Res Grp, Leeds, W Yorkshire, England.
   [Bennett, Michael I.] Univ Lancaster, Int Observ End Life Care, Lancaster, England.
C3 Leeds Beckett University; University of Leeds; Lancaster University
RP Paley, CA (corresponding author), Leeds Metropolitan Univ, Fac Hlth, Leeds LS1 3HE, W Yorkshire, England.
EM biodynamics.physiotherapy@tesco.net
RI Paley, Carole Anne/AAM-2469-2020; Bennett, Michael/A-1620-2009
OI Paley, Carole Anne/0000-0002-6335-2666; Bennett,
   Michael/0000-0002-8369-8349
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NR 75
TC 22
Z9 27
U1 1
U2 32
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2011
VL 2011
BP 1
EP 8
DI 10.1093/ecam/neq020
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 802PO
UT WOS:000293523700001
PM 21799687
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Yang, YL
   Wen, J
   Hong, JY
AF Yang, Yulan
   Wen, Jian
   Hong, Jianyun
TI The Effects of Auricular Therapy for Cancer Pain: A Systematic Review
   and Meta-Analysis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID POINT ACUPRESSURE; MANAGEMENT; UNDERTREATMENT; DYSMENORRHEA;
   ACUPUNCTURE; PREVALENCE; RELIEF; ADULTS
AB Objective. This study aims to systematically assess the efficacy and safety of auricular therapy for cancer pain. Methods. A systematic search was conducted using PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Data, and CBM for randomized controlled trials (RCTs). Review Manager 5.3 was used for meta-analysis. Results. Of the 275 screened studies, nine RCTs involving 783 patients with cancer pain were systematically reviewed. Compared with drug therapy, auricular therapy plus drug therapy has significant advantages both in the effective rate for pain relief (RR = 1.40; 95% CI 1.22, 1.60; P<0.00001) and adverse effects rate (RR = 0.46; 95% CI 0.37, 0.58; P<0.00001). And the result revealed that auricular acupuncture had superior pain-relieving effects as compared with sham auricular acupuncture (SMD = -1.45; 95% CI -2.80, -0.09; P=0.04). However, the analysis indicated no difference on the effective rate for pain relief between auricular therapy and drug therapy (RR = 1.24; 95% CI 0.71, 2.16; P=0.46). Conclusion. Our meta-analysis indicated that auricular therapy is effective and safe for the treatment of cancer pain, and auricular therapy plus drug therapy is more effective than drug therapy alone, whether in terms of pain relief or adverse reactions. However, the included RCTs had some methodological limitations; future large, rigor, and high-quality RCTs are still needed to confirm the benefits of auricular therapy on cancer pain.
C1 [Yang, Yulan; Hong, Jianyun] Maoming Peoples Hosp, Dept Acupuncture, Maoming, Guangdong, Peoples R China.
   [Wen, Jian] Maoming Peoples Hosp, Dept Oncol, Maoming, Guangdong, Peoples R China.
RP Yang, YL (corresponding author), Maoming Peoples Hosp, Dept Acupuncture, Maoming, Guangdong, Peoples R China.
EM leleyangyulan@163.com; wenjian218@163.com; hongjianyunmm@sina.cn
RI Yang, Yulan/HJB-0012-2022
OI Yang, Yulan/0000-0001-8412-6425
FU High-Level Hospital Construction Research Project of Maoming People's
   Hospital
FX This research was supported by High-Level Hospital Construction Research
   Project of Maoming People's Hospital.
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NR 34
TC 33
Z9 41
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD MAY 25
PY 2020
VL 2020
AR 1618767
DI 10.1155/2020/1618767
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LY5AM
UT WOS:000540541100001
PM 32565846
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Arias, F
   Zarandona, U
   Ibáñez-Beróiz, B
   Ibáñez, R
   Campo, M
   Cacicedo, J
   García-Rueda, N
   Baztán, B
   Villanueva, R
   Fresán, M
   Redín, I
   Osés, AT
   Hurtado, V
   Villafranca, I
   Iancu, V
   Almeida, P
   Moreno, N
   Cadena, S
   Carruesco, I
   Allegue, M
   González, AB
AF Arias, Fernando
   Zarandona, Uxue
   Ibanez-Beroiz, Berta
   Ibanez, Reyes
   Campo, Maider
   Cacicedo, Jon
   Garcia-Rueda, Noelia
   Baztan, Beatriz
   Villanueva, Raquel
   Fresan, Marta
   Redin, Inaki
   Oses, Ana T.
   Hurtado, Victoria
   Villafranca, Ines
   Iancu, Vasti
   Almeida, Pilar
   Moreno, Nieves
   Cadena, Soraya
   Carruesco, Irene
   Allegue, Marian
   Gonzalez, Ana B.
CA PREDORT Collaborative Grp
TI Prevalence and characterization of pain in radiation oncology: the
   PREDORT multicenter cross-sectional study
SO CLINICAL & TRANSLATIONAL ONCOLOGY
LA English
DT Article
DE Pain and radiotherapy services; Oncologic pain; Pain prevalence
ID CANCER-TREATMENT; RADIOTHERAPY; INTERFERENCE; MODERATE; MILD
AB Background Pain in cancer patients has enormous impact on their quality-of-life. Radiation therapy (RT) is a cornerstone in cancer treatment. The objective of the PREDORT study is to estimate the prevalence of pain in patients attending at Radiation Oncology (RO) Services. Methods A prospective, multicenter study was designed for patients treated at the RO Services of reference hospitals. Patients were seen in their initial Nursing consultation, during which key data was collected, including demographic and comorbidities data, medical history, and oncological and pain characteristics. The study has received approval from the Ethics Committee of Navarra, and all patients signed the Informed Consent. Results Of the 860 participating patients, 306 reported some type of pain, which implies a prevalence of 35.6%. Of them, 213 identified a cause of oncological origin. The proportion of pain was similar among sexes, but the proportion of non-cancer pain was higher among women (p < 0.05). Regarding pain intensity, the magnitude of breakthrough pain in patients with oncological pain is nearly 1 point greater than in patients with non-oncological pain (7.53 vs 6.81; p = 0.064). Cancer pain is more likely to be limiting of normal life than non-cancer pain (59% versus 38%, p < 0.001). Regarding analgesic treatment, only 60/306 patients (19.6%) were receiving strong opioids. There were 68 patients with pain without any treatment (22.2%). Conclusions The prevalence of pain in cancer patients referred to RO services is 35.6%, with the prevalence of exclusively oncological pain being 24.8%. Understanding and addressing oncological pain is essential to provide comprehensive care to patients.
C1 [Arias, Fernando; Zarandona, Uxue; Garcia-Rueda, Noelia; Baztan, Beatriz; Villanueva, Raquel; Fresan, Marta; Redin, Inaki; Oses, Ana T.; Hurtado, Victoria; Villafranca, Ines; Iancu, Vasti; Almeida, Pilar; Moreno, Nieves] Univ Hosp Navarre, Radiat Oncol Dept, Irunlarrea 3, Pamplona, Spain.
   [Ibanez-Beroiz, Berta; Ibanez, Reyes] Univ Hosp Miguel Servet, Zaragoza, Spain.
   [Campo, Maider; Cadena, Soraya; Carruesco, Irene] Univ Hosp Alava, Vitoria, Spain.
   [Cacicedo, Jon; Allegue, Marian; Gonzalez, Ana B.] Univ Hosp Cruces, Bilbao, Spain.
C3 Servicio Navarro de Salud - Osasunbidea; Miguel Servet University
   Hospital; Hospital Universitario Cruces
RP Arias, F (corresponding author), Univ Hosp Navarre, Radiat Oncol Dept, Irunlarrea 3, Pamplona, Spain.
EM farias.delavega@outlook.es
RI García-Rueda, Noelia/L-2473-2017; Ibáñez, Berta/A-6924-2017; campo,
   Maider/PFR-8047-2026; arias, fernando/C-1602-2019; Salazar Almeida,
   Pilar Aide/LZH-7569-2025
OI García-Rueda, Noelia/0000-0003-4724-4232; Ibáñez,
   Berta/0000-0002-7797-4845; arias, fernando/0000-0003-1288-9356; 
FU Fundacin Grnenthal Espaa
FX No Statement Available
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1699-048X
EI 1699-3055
J9 CLIN TRANSL ONCOL
JI Clin. Transl. Oncol.
PD FEB
PY 2025
VL 27
IS 2
BP 778
EP 784
DI 10.1007/s12094-024-03603-4
EA JUL 2024
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA U2G5S
UT WOS:001283205100003
PM 39078470
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Mi, WL
   Mao-Ying, QL
   Wang, XW
   Li, X
   Yang, CJ
   Jiang, JW
   Yu, J
   Wang, J
   Liu, Q
   Wang, YQ
   Wu, GC
AF Mi, Wen-Li
   Mao-Ying, Qi-Liang
   Wang, Xiao-Wei
   Li, Xiu
   Yang, Chang-Jiang
   Jiang, Jian-Wei
   Yu, Jin
   Wang, Jun
   Liu, Qiong
   Wang, Yan-Qing
   Wu, Gen-Cheng
TI Involvement of Spinal Neurotrophin-3 in Electroacupuncture Analgesia and
   Inhibition of Spinal Glial Activation in Rat Model of Monoarthritis
SO JOURNAL OF PAIN
LA English
DT Article
DE Monoarthritis; electroacupuncture; neurotrophin-3; glia; proinflammatory
   cytokines
ID NEUROPATHIC PAIN; DOWN-REGULATION; GFR-ALPHA-1 EXPRESSION; THERMAL
   HYPERALGESIA; PATHOLOGICAL PAIN; CONTROLLED-TRIAL; NT-3 EXPRESSION;
   SENSORY NEURONS; ACUPUNCTURE; OSTEOARTHRITIS
AB Although electroacupuncture (EA) has been proven to effectively relieve pain associated with arthritis, the underlying mechanism of EA analgesia requires further investigation. Here, the involvement of spinal neurotrophin-3 (NT-3) in EA's analgesic effects on complete Freund's adjuvant (CFA)-induced inflammatory pain was examined. The present study demonstrated that: 1) repeated EA stimulation of ipsilateral GB30 and GB34 acupoints remarkably suppressed CFA-induced hyperalgesia; 2) EA treatment markedly enhanced the upregulation of spinal NT-3 mRNA and protein levels following CFA injection; 3) antisense oligodeoxynucleotides (ODN) specifically against NT-3 intrathecally administered during EA treatment for 7 days significantly attenuated the EA analgesia; and 4) the suppressed expression of spinal GFAP (astrocytic marker), OX-42 (microglial marker) as well as proinflammatory cytokines, interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by EA treatment was significantly attenuated following NT-3 antisense ODN delivery. These results suggested that endogenous NT-3 may be involved in the analgesic effect of EA on inflammatory pain in rats, mediated through the inhibition of spinal glial activity as well as proinflammatory cytokine production.
   Perspective: The present study may initiate a discussion on the possible roles of NT-3/glia/cytokines in the therapeutic effects of acupuncture and provide insight on the mechanism underlie the analgesic effects of acupuncture on pain associated with arthritis. (C) 2011 by the American Pain Society
C1 [Mi, Wen-Li; Mao-Ying, Qi-Liang; Wang, Xiao-Wei; Li, Xiu; Yang, Chang-Jiang; Jiang, Jian-Wei; Yu, Jin; Wang, Jun; Liu, Qiong; Wang, Yan-Qing; Wu, Gen-Cheng] Fudan Univ, Dept Integrat Med & Neurobiol, Inst Acupuncture Res, State Key Lab Med Neurobiol,Inst Brain Sci,Shangh, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Wang, YQ (corresponding author), Fudan Univ, Dept Integrat Med & Neurobiol, Inst Acupuncture Res, State Key Lab Med Neurobiol,Inst Brain Sci,Shangh, POB 291,138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China.
EM wangyanqing@shmu.edu.cn
RI ; Wang, Jun/G-5447-2010; Mi, Wenli/P-5541-2019
OI Liu, Qiong/0000-0002-3480-0327; 
FU National Natural Science Foundation [30970975, 30821002, 30800332,
   31000495]; National Key Basic Research Program of China [2006CB504509,
   2007CB512502]; Program for Changjiang Scholars and Innovative Research
   Team in University (PCSIRT) [IRT0522]; Research Fund for the Doctoral
   Program of Higher Education of China [20100071120046]; Fundamental
   Research Funds for the Central Universities; Young Scientist Foundation
   of Fudan University
FX Supported by the National Natural Science Foundation (30970975,
   30821002, 30800332, 31000495); the National Key Basic Research Program
   of China (2006CB504509, 2007CB512502); the Program for Changjiang
   Scholars and Innovative Research Team in University (PCSIRT) (IRT0522);
   Research Fund for the Doctoral Program of Higher Education of China
   (20100071120046); the Fundamental Research Funds for the Central
   Universities, and Young Scientist Foundation of Fudan University.
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NR 33
TC 37
Z9 39
U1 0
U2 24
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD SEP
PY 2011
VL 12
IS 9
BP 974
EP 984
DI 10.1016/j.jpain.2011.03.002
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 819ZZ
UT WOS:000294876600004
PM 21680256
DA 2026-01-16
ER

PT J
AU Jiang, B
   Zhong, XM
   Fang, JF
   Zhang, AJ
   Wang, W
   Liang, Y
   Fang, JQ
   Chen, F
   Du, JY
AF Jiang, Bin
   Zhong, Xuemei
   Fang, Junfan
   Zhang, Aijun
   Wang, Wen
   Liang, Yi
   Fang, Jianqiao
   Chen, Feng
   Du, Junying
TI Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone
   Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the
   Spinal Dorsal Horn
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE electroacupuncture; bone cancer pain; morphine tolerance; LY294002;
   IGF-1; PI3K; Akt; JNK1; 2
ID BETA-ARRESTIN 2; PROTEIN-KINASE B/AKT; ANALGESIC TOLERANCE; ACTIVATION;
   CONTRIBUTES; ACUPUNCTURE; INVOLVEMENT; MODEL; MECHANISM; TRPV1
AB Purpose:
   Morphine is often used for the treatment of moderate and severe cancer pain, but long-term use can lead to morphine tolerance. Methods for effectively inhibiting morphine tolerance and the related mechanism of action are of great significance for the treatment of cancer pain. Previous studies have shown that electroacupuncture (EA) can inhibit the occurrence of morphine tolerance, but the mechanism is not yet clear. The aim of the present study was to explore the signaling pathway by which EA attenuates the development of bone cancer pain (BCP)-morphine tolerance (MT).
   Materials and methods:
   Changes in the paw withdrawal threshold (PWT) of rats with bone cancer pain-morphine tolerance were observed in a study of EA combined with intrathecal injection of a PI3K inhibitor (LY294002) or agonist (insulin-like growth factor-1 [IGF-1]). We also tested the protein expression of phosphorylated phosphatidylinositol 3-kinase (p-PI3K), phosphorylated protein kinase B (p-Akt), phosphorylated c-Jun NH2-terminal kinase 1/2 (p-JNK1/2), and beta-arrestin2 in the L4-6 spinal dorsal horn of rats.
   Results:
   The protein expression of p-PI3K, p-Akt, p-JNK1/2, and beta-arrestin2 was upregulated in the L4-6 spinal dorsal horn of rats with bone cancer pain and bone cancer pain-morphine tolerance. EA delayed the occurrence of morphine tolerance in rats with bone cancer pain and downregulated the protein expression of p-PI3K, p-Akt, p-JNK1/2, and beta-arrestin2 in the L4-6 spinal dorsal horn of rats with bone cancer pain-morphine tolerance. Intrathecal injection of LY294002 attenuated the development of morphine tolerance and downregulated the protein expression of p-Akt, p-JNK1/2, and beta-arrestin2 in the spinal dorsal horn of rats with bone cancer pain-morphine tolerance. In addition, the inhibitory effect of EA on morphine tolerance was reversed by IGF-1.
   Conclusion:
   The mechanism underlying the ability of EA to attenuate morphine tolerance may be associated with inhibition of the PI3K/Akt/JNK1/2 signaling pathway.
C1 [Jiang, Bin; Zhang, Aijun; Chen, Feng] Jiaxing Univ, First Hosp Jiaxing, Affiliated Hosp, 1882 South Zhonghuan Rd, Jiaxing 314001, Zhejiang, Peoples R China.
   [Jiang, Bin; Zhong, Xuemei; Fang, Junfan; Wang, Wen; Liang, Yi; Fang, Jianqiao; Du, Junying] Zhejiang Chinese Med Univ, Dept Neurobiol & Acupuncture Res, Third Clin Med Coll, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
   [Zhong, Xuemei] Zhejiang Univ Tradit Chinese Med, Second Clin Coll, Hangzhou, Zhejiang, Peoples R China.
C3 Jiaxing University; Zhejiang Chinese Medical University; Zhejiang
   Chinese Medical University
RP Chen, F (corresponding author), Jiaxing Univ, First Hosp Jiaxing, Affiliated Hosp, 1882 South Zhonghuan Rd, Jiaxing 314001, Zhejiang, Peoples R China.; Du, JY (corresponding author), Zhejiang Chinese Med Univ, Dept Neurobiol & Acupuncture Res, Third Clin Med Coll, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
EM cfly149@126.com; dujunying0706@163.com
RI chen, feng/PDX-5000-2025; Du, Junying/AEV-3719-2022
OI Fang, Jianqiao/0000-0002-5155-8544
FU Zhejiang Provincial Natural Science Fund of China [LY16H270017]; Jiaxing
   Key Discipline of Chinese and Western Medicine-Acupuncture (Derived)
   [2019XK-B01]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Zhejiang Provincial Natural Science Fund of China
   (LY16H270017) and the Jiaxing Key Discipline of Chinese and Western
   Medicine-Acupuncture (Derived) (2019XK-B01).
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NR 47
TC 21
Z9 22
U1 2
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAR
PY 2021
VL 20
AR 1534735421995237
DI 10.1177/1534735421995237
PG 13
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA QT4PJ
UT WOS:000626570500001
PM 33660537
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Dyer, L
   Venton, K
   Forrester, M
AF Dyer, Lisa
   Venton, Kate
   Forrester, Max
TI Home electroacupuncture for persistent postsurgical pain: a patient's
   report
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE Oral & Maxillofacial Surgery; Pain Management; Acupuncture
ID CANCER-RELATED FATIGUE; ACUPUNCTURE
AB A 30-year-woman presented with iatrogenic myofascial facial pain of 12months' duration after surgical treatment for bilateral temporomandibular joint dysfunction. Limited response to manual acupuncture was followed by a trial of electroacupuncture. Response to electroacupuncture was limited in duration and one option was to teach her partner to perform electroacupuncture at home. The patient and partner, trained in beauty therapy, embraced this idea and it proved equally effective as therapist-provided acupuncture. We describe this case report from the perspective of the patient, caregiver or acupuncture partner and therapist. Home electroacupuncture seems to be safe, acceptable and practicable as a maintenance treatment for patients with persistent postsurgical pain of myofascial origin.
C1 [Forrester, Max] Taunton & Somerset NHS Fdn Trust, Dept Orthopaed, Musgrove Pk Hosp, Taunton TA1 5DA, Somerset, England.
C3 Musgrove Park Hospital
RP Forrester, M (corresponding author), Taunton & Somerset NHS Fdn Trust, Dept Orthopaed, Musgrove Pk Hosp, Taunton TA1 5DA, Somerset, England.
EM maxforrester@yahoo.co.uk
CR Adler Z., 2012, BMC Complement. Altern. Med., V12, pP125, DOI [10.1186/1472-6882-12-S1-P125, DOI 10.1186/1472-6882-12-S1-P125]
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NR 32
TC 5
Z9 5
U1 1
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD DEC
PY 2013
VL 31
IS 4
BP 425
EP 429
DI 10.1136/acupmed-2013-010421
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 266BI
UT WOS:000327996900013
PM 23969146
DA 2026-01-16
ER

PT J
AU Zhang, YJ
   Zhang, YR
   Liu, SZ
   Li, BC
   Song, Z
   Han, Q
   Wang, C
   Wang, YW
   Yu, YX
   Xia, HJ
   Wang, C
   Li, J
AF Zhang, Yanji
   Zhang, Yingrong
   Liu, Suzhen
   Li, Bocun
   Song, Zhe
   Han, Qi
   Wang, Chang
   Wang, Yiwei
   Yu, Yanxin
   Xia, Hongjie
   Wang, Chun
   Li, Jia
TI Acupuncture for cancer pain: a scoping review of systematic reviews and
   meta-analyses
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE acupuncture; cancer pain; scoping review; systematic reviews and
   meta-analyses; alternative medicine (AM)
ID THERAPIES; MANAGEMENT; QUALITY
AB Background: Due to the effectiveness and safety, acupuncture, one of the traditional therapies of Chinese medicine, has been widely used in clinical practice globally. A few systematic review or meta-analyses have proved its effectiveness and safety towards patients with cancer pain, while there are no syntheses among those evidence. The aim of this scoping review is to summarize the evidence from systematic reviews of acupuncture for the treatment of cancer pain and evaluate the breadth and methodological quality of these evidence as well. Methods: The scoping review process was guided by the methodology framework of Preferred Reporting Items for Systematic Reviews and MetaAnalyses extension for scoping reviews (PRISMA ScR) and "Arkseyand O'Malley six-stage framework". Electronic searches were carried out in several online databases from inception to Jan 2022. Systematic reviews and meta-analyses that involve any type of acupuncture for patients with cancer pain will be included. A pair of reviewers independently screened full texts. Moreover, review characteristics were extracted, and methodological quality was assessed using the AMSTAR 2 tool. Results: Twenty-five systematic reviews and meta-analyses were included. Manual acupuncture is the most frequently included types of test group intervention (48%), followed by acupuncture + medicine (28%), and auricular acupuncture (12%). All the reviews have declared that acupuncture is an effective method for cancer pain treatment. Eleven reviews (44%) aiming at evaluating the safety also have confirmed that acupuncture is safe for treating cancer pain. However, most included studies were conducted in China. With certain geographical limitations, the findings were not representative within the region. The results of our review may owe to the synthesis of all kinds of cancer pain, and only 2 reviews described the type of cancer pain in detail.Conclusions: This scoping review synthesizes and evaluates existing evidence of acupuncture for cancer pain. From this scoping review of systematic reviews and meta-analyses, there are clear recommendations for future studies: expanding the region of research in the world and trying to conduct the study of different types of cancer pain in details as much as possible. Evidences of acupuncture for cancer pain can inform clinical decision-making.
C1 [Zhang, Yanji; Zhang, Yingrong; Liu, Suzhen; Li, Bocun; Wang, Yiwei; Yu, Yanxin; Xia, Hongjie; Wang, Chun; Li, Jia] Hubei Univ Chinese Med, Coll Acupuncture & Orthoped, Wuhan, Hubei, Peoples R China.
   [Song, Zhe; Wang, Chang] Hubei Univ Sci & Technol, Sch Biomed Engn & Imaging, Xianning, Hubei, Peoples R China.
   [Han, Qi] Hubei Univ Sci & Technol, Affiliated Hosp 1, Xianning Cent Hosp, Xianning, Hubei, Peoples R China.
   Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada.
C3 Hubei University of Chinese Medicine; Hubei University of Science &
   Technology; Hubei University of Science & Technology; University of
   Alberta
RP Wang, C; Li, J (corresponding author), Hubei Univ Chinese Med, Coll Acupuncture & Orthoped, Wuhan, Hubei, Peoples R China.
EM hispen@126.com; ljlijia@163.com
RI Xia, Hongjie/M-9241-2019
OI zhang, yanji/0000-0001-7059-8974
FU National Administration of Traditional Chinese Medicine [75[2022]];
   Seventh Batch of National Old Chinese Medicine Experts Academic
   Experience Inheritance Project [272[2021]]; Hubei University of Science
   and Technology Fund Project [2022-23X05]; Hubei Province Natural Science
   Foundation [2018XYA003]; 2018 Xianning Central Hospital Scientific
   Research Project [[2019]47]; 2nd Hubei Province's Outstanding Medical
   Academic Leader Program [284 (2018)]; Qihuang Engineering Project of
   National Administration of Traditional Chinese Medicine;  [2022CFB367]
FX Supported by National Administration of Traditional Chinese Medicine:
   The construction project of the national famous Chinese medicine expert
   inheritance studio in 2022 (National Chinese Medicine Education Letter
   No.75[2022], Professor Wang Huang); The Seventh Batch of National Old
   Chinese Medicine Experts Academic Experience Inheritance Project
   (National Chinese Medicine Education Letter No.272[2021]); Hubei
   University of Science and Technology Fund Project (No. 2022-23X05 to Zhe
   Song); Hubei Province Natural Science Foundation (2022CFB367); 2018
   Xianning Central Hospital Scientific Research Project (2018XYA003); The
   2nd Hubei Province's Outstanding Medical Academic Leader Program (Health
   Commission of Hubei Province Notice No.[2019]47); Qihuang Engineering
   Project of National Administration of Traditional Chinese Medicine
   (Document No. 284 (2018)).
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NR 46
TC 11
Z9 12
U1 2
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD MAY 15
PY 2023
VL 13
AR 1169458
DI 10.3389/fonc.2023.1169458
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA H8IV5
UT WOS:000998342300001
PM 37256179
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, ZQ
   Wang, XF
   Feng, C
   Fei, YT
   Liu, JP
AF Li, Zhi-Qiang
   Wang, Xue-Feng
   Feng, Cao
   Fei, Yu-Tong
   Liu, Jian-Ping
TI Global trends of acupuncture clinical research on analgesia from 2010 to
   2023: a bibliometric and visualization analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE acupuncture; analgesia; bibliometric analysis; hotspots; visualization
   analysis
ID POSTDURAL PUNCTURE HEADACHE; CHRONIC PAIN; THERAPY
AB Objective: Acupuncture, acknowledged as a potent non-pharmacological therapy, is frequently employed to alleviate pain. Despite its widespread use, there has been a lack of overarching bibliometric analysis of clinical research on acupuncture analgesia. We aimed to summarize current patterns, hotspots, and development trends in this field through bibliometric analysis. Methods: This study evaluates academic publications retrieved from the Web of Science database (2010.01-2023.09) concerning acupuncture analgesia in clinical settings. All primary and secondary studies on humans were included. To track global developmental trends, we employed several software for analyzing annual publication volumes, countries/regions, institutions, authors, cited authors, journals, cited journals, references, and keywords and to draw collaborative networks and reference co-citation network maps. Results: The final search encompassed 7,190 relevant studies, including 1,263 randomized controlled trials (RCTs) and 1,293 systematic reviews and meta-analyses. The results indicated a gradual increase in the number of annual publications on acupuncture analgesia in clinical practice. Among countries and institutions, China (2,139) and Chengdu University of Traditional Chinese Medicine (258) ranked first. Liang FR (89 articles) was the most prolific author, while MacPherson H (604) was the most cited author. MEDICINE (455) was the most productive journal, and Pain (2,473/0.20) ranked first in both the frequency and centrality of cited journals. Notably, the most frequently cited reference was a systematic review of individual patient data on acupuncture carried out for chronic pain that was published by Vickers Andrew J in 2012 (156). Burst analysis identified frontier research areas for 2010-2020, encompassing network meta-analysis, case reports, dry needling, lumbar disc herniation, cancer, post-herpetic neuralgia, insomnia, and bibliometric analysis. Conclusion: This study outlines current trends and potential future research hotspots in clinical acupuncture analgesia over the past decade. Findings emphasize the necessity for enhanced international collaboration to improve research output and translation.
C1 [Li, Zhi-Qiang; Wang, Xue-Feng; Feng, Cao; Fei, Yu-Tong; Liu, Jian-Ping] Beijing Univ Chinese Med, Ctr Evidence based Chinese Med, Beijing, Peoples R China.
   [Liu, Jian-Ping] UiT Arctic Univ Norway, Fac Hlth Sci, Natl Res Ctr Complementary & Alternat Med NAFKAM, Dept Community Med, Tromso, Norway.
C3 Beijing University of Chinese Medicine; UiT The Arctic University of
   Tromso
RP Liu, JP (corresponding author), Beijing Univ Chinese Med, Ctr Evidence based Chinese Med, Beijing, Peoples R China.; Liu, JP (corresponding author), UiT Arctic Univ Norway, Fac Hlth Sci, Natl Res Ctr Complementary & Alternat Med NAFKAM, Dept Community Med, Tromso, Norway.
EM liujp@bucm.edu.cn
OI Li, Zhiqiang/0000-0003-1492-4995
FU Innovation Team and Talents Cultivation Program of National
   Administration of Traditional Chinese Medicine [ZYYCXTD-C-202006];
   High-level traditional Chinese medicine key subject construction project
   [ZYYZDXK-2023249]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. The study was
   supported by the Innovation Team and Talents Cultivation Program of
   National Administration of Traditional Chinese Medicine
   (ZYYCXTD-C-202006) and the High-level traditional Chinese medicine key
   subject construction project of National Administration of Traditional
   Chinese Medicine-Evidence-based Traditional Chinese Medicine
   (ZYYZDXK-2023249).
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NR 44
TC 5
Z9 9
U1 3
U2 44
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD APR 11
PY 2024
VL 15
AR 1368988
DI 10.3389/fneur.2024.1368988
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA OL8P2
UT WOS:001207522500001
PM 38665996
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, RX
   Lao, LX
   Ren, K
   Berman, BM
AF Zhang, Ruixin
   Lao, Lixing
   Ren, Ke
   Berman, Brian M.
TI Mechanisms of Acupuncture-Electroacupuncture on Persistent Pain
SO ANESTHESIOLOGY
LA English
DT Review
ID SPINAL DORSAL-HORN; ANTERIOR CINGULATE CORTEX; INDUCED INFLAMMATORY
   PAIN; TUMOR-NECROSIS-FACTOR; PERIPHERAL ELECTRICAL-STIMULATION;
   METABOTROPIC GLUTAMATE RECEPTORS; LOW-FREQUENCY ELECTROACUPUNCTURE;
   CORTICOTROPIN-RELEASING HORMONE; RANDOMIZED CONTROLLED-TRIAL;
   IRRITABLE-BOWEL-SYNDROME
AB In the last decade, preclinical investigations of electroacupuncture mechanisms on persistent tissue injury (inflammatory), nerve injury (neuropathic), cancer, and visceral pain have increased. These studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms. These include opioids, which desensitize peripheral nociceptors and reduce proinflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal N-methyl-d-aspartate receptor subunit GluN1 phosphorylation. Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management which can forestall the side effects of often-debilitating pharmaceuticals.
C1 [Zhang, Ruixin; Lao, Lixing; Berman, Brian M.] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA.
   [Ren, Ke] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Zhang, RX (corresponding author), Ctr Integrat Med, 685 W Baltimore St,MSTF Rm 8-22, Baltimore, MD 21201 USA.
EM rzhan001@umaryland.edu
RI Lao, Lixing/P-9107-2019; Zhang, Ruixin/LBI-2317-2024
OI Lao, Lixing/0000-0003-0198-9714; 
FU National Center for Complementary and Alternative Medicine at the
   National Institutes of Health, Bethesda, Maryland [P01AT002605,
   R21AT005474]
FX This work was made possible by grant numbers P01AT002605 and R21AT005474
   from the National Center for Complementary and Alternative Medicine at
   the National Institutes of Health, Bethesda, Maryland.
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NR 207
TC 636
Z9 770
U1 6
U2 376
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-3022
EI 1528-1175
J9 ANESTHESIOLOGY
JI Anesthesiology
PD FEB
PY 2014
VL 120
IS 2
BP 482
EP 503
DI 10.1097/ALN.0000000000000101
PG 22
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA AB1NU
UT WOS:000331559900027
PM 24322588
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Nia, HS
   Sharif, SP
   Yaghoobzadeh, A
   Yeoh, KK
   Goudarzian, AH
   Soleimani, MA
   Jamali, S
AF Nia, Hamid Sharif
   Sharif, Saeed Pahlevan
   Yaghoobzadeh, Ameneh
   Yeoh, Ken Kyid
   Goudarzian, Amir Hossein
   Soleimani, Mohammad Ali
   Jamali, Saman
TI Effect of acupressure on pain in Iranian leukemia patients: A randomized
   controlled trial study
SO INTERNATIONAL JOURNAL OF NURSING PRACTICE
LA English
DT Article
DE acupressure; cancer; Iran; leukemia; nursing; pain
ID SYMPTOM MANAGEMENT; POSTOPERATIVE PAIN; CANCER PAIN; ACUPUNCTURE;
   THERAPY; ANXIETY; NAUSEA
AB Nonpharmacological methods of pain relief such as acupressure are becoming increasingly popular worldwide. Practitioners often claim that such methods are highly effective and less invasive than analgesic drugs, but available empirical evidence is largely inconclusive. This study aimed to test the hypothesis that, postacupressure intervention, the amount of pain experienced by sampled leukemia patients, who received acupressure in addition to standard care, will reduce substantially compared to patients who received only routine treatment. This controlled trial was undertaken with hospitalized leukemia patients between February and June 2015. Our primary sample consisted of 100 participants who were randomly allocated to 2 groups. One (intervention) group underwent 12 acupressure sessions in addition to standard treatment while the control group received no intervention apart from being given the standard treatment for leukemia. The visual analogue scale was used to measure the levels of pain experienced. No significant differences were found between the 2 groups across 12 interventions. However, each group reported significantly different pain level changes before and after each intervention, suggested that the acupressure method was effective in reducing pain in the short term. Nurses are able to apply this complementary therapy alongside other procedures to manage these patients' pain. It is recommended that further studies be conducted to better understand the specific conditions under which acupressure can provide effective pain relief.
C1 [Nia, Hamid Sharif] Mazandaran Univ Med Sci, Sch Nursing & Midwifery Amol, Sari, Iran.
   [Sharif, Saeed Pahlevan] Taylors Business Sch, Subang Jaya, Malaysia.
   [Yaghoobzadeh, Ameneh] Univ Tehran Med Sci, Tehran, Iran.
   [Yeoh, Ken Kyid] Univ Nottingham, Sch Business, Semenyih Selangor Darul Ehsan, Univ Nottingham Malaysia Campus, Semenyih, Selangor Darul, Malaysia.
   [Goudarzian, Amir Hossein; Jamali, Saman] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran.
   [Soleimani, Mohammad Ali] Qazvin Univ Med Sci, Social Determinants Hlth Res Ctr, Qazvin, Iran.
C3 Mazandaran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Nottingham Malaysia; Mazandaran University of
   Medical Sciences; Qazvin University of Medical Sciences (QUMS)
RP Goudarzian, AH (corresponding author), Mazandaran Univ Med Sci, Student Res Comm, Nursing, Sari, Iran.
EM amir_sari@yahoo.com
RI Pahlevan Sharif, Saeed/AAX-4444-2020; Goudarzian, Amir/AAE-4805-2020;
   Sharif-Nia, Hamid/E-6915-2016; Yaghoobzadeh, Ameneh/L-3906-2017;
   Soleimani, Mohammad Ali/F-1200-2016
OI Pahlevan Sharif, Saeed/0000-0001-8082-4541; Sharif-Nia,
   Hamid/0000-0002-5570-3710; Yaghoobzadeh, Ameneh/0000-0002-2175-0260;
   Soleimani, Mohammad Ali/0000-0002-6931-6412
FU Mazandaran University of Medical Sciences [360]
FX Mazandaran University of Medical Sciences, Grant/Award Number: 360
CR Aghamiri Z, 2005, HAYAT, V11, P19
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   Anderson JG, 2015, EXPLORE-NY, V11, P208, DOI 10.1016/j.explore.2015.02.006
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NR 34
TC 18
Z9 22
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1322-7114
EI 1440-172X
J9 INT J NURS PRACT
JI Int. J. Nurs. Pract.
PD APR
PY 2017
VL 23
IS 2
AR e12513
DI 10.1111/ijn.12513
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ER1IT
UT WOS:000398544300003
PM 28058748
DA 2026-01-16
ER

PT J
AU Bossi, P
   Antonuzzo, A
   Armento, G
   Consoli, F
   Giuliani, J
   Giusti, R
   Lucchesi, M
   Mirabile, A
   Palermo, L
   Scagliarini, S
AF Bossi, Paolo
   Antonuzzo, Andrea
   Armento, Grazia
   Consoli, Francesca
   Giuliani, Jacopo
   Giusti, Raffaele
   Lucchesi, Maurizio
   Mirabile, Aurora
   Palermo, Loredana
   Scagliarini, Sarah
TI What to Do and What Not to Do in the Management of Cancer Pain: A
   Physician Survey and Expert Recommendations
SO CANCER MANAGEMENT AND RESEARCH
LA English
DT Article
DE cancer pain; pain management; precision medicine; digital medicine
ID BREAKTHROUGH-PAIN; PREVALENCE; BARRIERS
AB Background: Despite the prevalence of pain among patients with cancer and the availability of pertinent guidelines, the clinical management of oncological pain is decisively insufficient. To address this issue, we evaluated current trends in clinical practice and subsequently generated a list of ten corrective actions-five things to do and five things not to do-for the diagnosis, management, and monitoring of cancer pain.
   Methods: The survey included 18 questions about clinical practice surrounding background pain and breakthrough cancer pain (BTcP). Survey questions were developed by a scientific board of 10 physician experts and communicated via email to an expanded panel of physicians in Italy. Responses were tabulated descriptively for analysis.
   Results: Of 51 invited physicians, 32 (63%) provided complete survey responses. The responses revealed several incongruencies with current guideline recommendations: physicians did not always diagnose or monitor pain using diagnostically validated or disease-specific instruments; frequently based clinical decision-making on time availability or convenience; and pharmacological therapy was often inappropriate (eg, prescribing NSAIDs or corticosteroids for BTcP). The list of corrective actions generated by the scientific board favored a guideline-oriented approach that systematically characterizes oncological pain and implements treatment based on pain characteristics (eg, fast-acting transmucosal opioids for BTcP) and evidence-based recommendations.
   Conclusion: Oncologists require better education and training about the diagnosis, treatment, and monitoring of oncological pain. Physicians should be aware of current guideline recommendations as well as available pharmacological tools for BTcP.
C1 [Bossi, Paolo; Consoli, Francesca] ASST Spedali Civili, Dept Med Oncol, 1 Brescia, I-25123 Brescia, Italy.
   [Antonuzzo, Andrea] Azienda Osped Univ Pisana, Med Oncol Unit SSN 1, Oncol Ctr, Pisa, Italy.
   [Armento, Grazia] Dept Med Oncol, Campus Biomed Univ Hosp, Rome, Italy.
   [Giuliani, Jacopo] Mater Salutis Hosp, Unit Dept Med Oncol, Legnago, Italy.
   [Giusti, Raffaele] St Andrea Univ Hosp, Unit Dept Med Oncol, Rome, Italy.
   [Lucchesi, Maurizio] Azienda Osped Univ Pisana, Pneumol Unit, Thorac Oncol Serv, Pisa, Italy.
   [Mirabile, Aurora] San Raffaele Univ Hosp, Dept Oncol, Milan, Italy.
   [Palermo, Loredana] IRCCS Giovanni Paolo, Unit Dept Med Oncol, Bari, Italy.
   [Scagliarini, Sarah] AORN Cardarelli, Unit Dept Med Oncol, Naples, Italy.
C3 Hospital Spedali Civili Brescia; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Fondazione Policlinico Universitario Campus
   Bio-Medico; University Campus Bio-Medico - Rome Italy; ULSS 9 Scaligera;
   Ospedale Mater Salutis di Legnago; Sapienza University Rome; Azienda
   Ospedaliera Sant'Andrea; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele
RP Bossi, P (corresponding author), ASST Spedali Civili, Dept Med Oncol, 1 Brescia, I-25123 Brescia, Italy.
EM paolo.bossi@unibs.it
RI Bossi, Paolo/IAR-1470-2023; Giusti, Raffaele/AAC-9723-2020; Giuliani,
   Jacopo/AAW-5524-2020; palermo, loredana/AAJ-9005-2020; Scagliarini,
   Sarah/LZE-2861-2025
OI Bossi, Paolo/0000-0003-0135-0224; 
FU Molteni Farmaceutici S.p.A.
FX This work was supported by an unconditional grant from Molteni
   Farmaceutici S.p.A.
CR Aapro M, 2020, SUPPORT CARE CANCER, V28, P4589, DOI 10.1007/s00520-020-05539-1
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NR 31
TC 5
Z9 5
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1322
J9 CANCER MANAG RES
JI Cancer Manag. Res.
PY 2021
VL 13
BP 5203
EP 5210
DI 10.2147/CMAR.S310651
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA TB8WG
UT WOS:000668225900001
PM 34234563
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, JX
   Lan, XD
   Cai, QC
   Lu, ZH
   Wang, YJ
AF Yang, Jiaxiang
   Lan, Xiangdong
   Cai, Qingcheng
   Lu, Ziheng
   Wang, Yanjun
TI Exercise Plus Acupuncture on Consensus Acupoints Versus Acupoints
   Selected by the Theory of Equal Impact on Tendons, Bones, and Muscles
   for Knee Osteoarthritis
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID NF-KAPPA-B; MATRIX METALLOPROTEINASES; MEDICAL-MANAGEMENT;
   RECOMMENDATIONS; PREVALENCE; PAIN
AB Context center dot Knee osteoarthritis (KOA) is a degenerative disorder that significantly affects patients' quality of life. Acupuncture and exercise are the most popular treatments currently. The outcomes for acupuncture for KOA, however, are controversial, with some researchers finding that the addition of acupuncture to exercise therapy provided no additional improvement in pain scores.
   Objective center dot The study intended to evaluate the therapeutic effects for KOA of exercise in combination with acupuncture on acupoints selected using the Traditional Chinse Medicine (TCM) theory of Equal Impact on Tendons, Bones, and Muscles (EITBM) in comparison with that of acupoints selected using classical consensus for the treatment.
   Design center dot The research team performed a randomized controlled trial.
   Setting center dot The study took place in the Department of Acupuncture and Moxibustion at the First Affiliated Hospital of Hebei University of Chinese Medicine in Shijiazhuang, Hebei, China.
   Participants center dot Participants were 70 patients with KOA who visited the hospital between December 2020 and February 2021.
   Intervention center dot Participants in both group received acupuncture plus exercise therapy. The research team randomly assigned participants to one of two groups: (1) 35 to the intervention group, which received acupuncture using acupoints selected using EITBM, and (2) 35 to the control group, which received acupuncture using the classical consensus acupoints. Both groups performed a 25-min session of acupuncture three times weekly for 4 weeks, with the exercise therapy following the acupuncture each time.
   Outcome Measures center dot The research team assessed clinical efficacy at baseline and postintervention. The primary outcome measures included assessments: (1) of knee joint pain using a visual analog scale (VAS), (2) of knee joint pain, flexibility, and function using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale; and (3) joint range of motion (ROM). The secondary outcome measures included measurement of serum levels of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and matrix metalloproteinase-13 (MMP-13) using enzyme-linked immunosorbent assays (ELISA).
   Results center dot The VAS and WOMAC scores significantly decreased for both groups between baseline and postintervention, and the intervention group's decrease was significantly greater than that of the control group. The ROM of knee flexion was significantly higher in both groups postintervention than at baseline, and the intervention group's increase was significantly higher than that of the control group. The serum IL-1 beta, TNF-alpha, and MMP-13 also significantly decreased postintervention in both groups, and the intervention group's levels were significantly lower than those of the control group. The total effective rate was 94.1% in the intervention group, 32 out of 34 participants, and 75.8% in the control group, 25 out of 33 participants, which was significantly different.
   Conclusions center dot Acupuncture, in combination with exercise, can relieve symptoms, improve joint function, and reduce pro-inflammatory cytokines (IL-1 beta and TNF-alpha) as well as MMP-13 for patients with KOA. The outcomes for acupuncture using EITBM acupoints were significantly better than those of the acupoints selected using classical consensus.
C1 [Yang, Jiaxiang; Lan, Xiangdong; Cai, Qingcheng; Lu, Ziheng; Wang, Yanjun] Hebei Univ Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei University of Chinese Medicine
RP Wang, YJ (corresponding author), Hebei Univ Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
EM wangyj8055@sina.com
FU National Key Research and Development Plan Key Special Program of TCM
   Modernization Research [2018YFC1707803]; Key Project of Hebei Provincial
   Administration of Traditional Chinese Medicine [Z2022009]; General
   Project of Scientific Research Plan of Hebei Administration of
   Traditional Chinese Medicine [2022057]; National Health and Medical
   Research Council (NHMRC) [2022057] Funding Source: National Health and
   Medical Research Council (NHMRC)
FX The National Key Research and Development Plan Key Special Program of
   TCM Modernization Research (No. 2018YFC1707803), the Key Project of
   Hebei Provincial Administration of Traditional Chinese Medicine (No.
   Z2022009), and the General Project of Scientific Research Plan of Hebei
   Administration of Traditional Chinese Medicine (No. 2022057) funded the
   study. The authors declare there is no conflict of interest in this
   study.
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NR 35
TC 1
Z9 2
U1 1
U2 8
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JUL-AUG
PY 2023
VL 29
IS 5
BP 262
EP 267
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M2TQ1
UT WOS:001028759700039
PM 37052974
DA 2026-01-16
ER

PT J
AU Cohen, SA
   Veleber, S
   Siman, J
   Guthrie, KA
   McMillen, K
   Heit, M
   Wadhera, S
   Daniels, J
   Hansen, K
   Jacoby, M
   Taromina, K
   Chin, S
   Romeo, M
   Langley, BO
   Coveler, AL
   Hannan, LM
   King, G
   Purcell, T
   Safyan, RA
   Shankaran, V
   Zhen, DB
   Chiorean, EG
   Greenlee, H
AF Cohen, Stacey A.
   Veleber, Susan
   Siman, Jonathan
   Guthrie, Katherine A.
   McMillen, Kerry
   Heit, Madilyn
   Wadhera, Sonia
   Daniels, Jonathan
   Hansen, Kjell
   Jacoby, Madeline
   Taromina, Katherine
   Chin, Samantha
   Romeo, Melissa
   Langley, Blake O.
   Coveler, Andrew L.
   Hannan, Lindsay M.
   King, Gentry
   Purcell, Tom
   Safyan, Rachael A.
   Shankaran, Veena
   Zhen, David B.
   Chiorean, E. Gabriela
   Greenlee, Heather
TI Use of acupuncture with acupressure in addition to standard-of-care
   cryotherapy to decrease chemotherapy-associated neuropathy in patients
   with gastrointestinal malignancies receiving oxaliplatin-based
   chemotherapy: Study protocol for a randomized, controlled pilot and
   feasibility study
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Colorectal cancer; Pancreatic cancer; Oxaliplatin; Peripheral neuropathy
ID INDUCED PERIPHERAL NEUROPATHY; III COLON-CANCER; PREVENTION; SURVIVAL;
   TRIAL; ELECTROACUPUNCTURE; GEMCITABINE; FOLFIRINOX
AB Background: Oxaliplatin is a key chemotherapeutic agent in the treatment of local and metastatic gastrointestinal (GI) malignancies. Dose density and treatment adherence can be limited by chemotherapy-induced peripheral neuropathy (CIPN). Early research suggests CIPN incidence and severity may be mitigated by acupuncture, but rigorous data in GI oncology patients is limited. Here, we describe the protocol of a randomized, waitlistcontrolled pilot study testing the use of preemptive of acupuncture plus acupressure to decrease CIPN and chemotherapy-related toxicities.Methods: Patients with a GI malignancy (n = 56) with planned 5-fluorouracil (5-FU) and oxaliplatin IV (FOLFOX, FOLFIRINOX) every 2 weeks are being recruited. Additional concurrent anti-neoplastic agents may be used. Enrolled patients are randomized 1:1 to a 3-month intervention of Arm A: acupuncture with acupressure and standard-of-care treatment, or Arm B: standard-of-care alone. In Arm A, on days 1 and 3 of each chemotherapy cycle a standardized acupuncture protocol is administered and patients are taught self-acupressure to perform daily between chemotherapy treatments. Patients in both arms are given standard-of-care oral and peripheral (hands/feet) ice chip cryotherapy during oxaliplatin administration. CIPN and other symptoms are assessed at baseline, 6 weeks, and 3 months from registration. The primary endpoint is CIPN severity at 3 months (EORTCCIPN 20). Additional endpoints evaluate CIPN incidence (CTCAE, Neuropen, tuning fork); incidence of pain, fatigue, nausea, oral dysesthesia, and anxiety; and feasibility (recruitment, retention, adherence, acceptability). If warranted, trial results will inform the design of a multi-center trial to expand testing of the intervention to a larger patient cohort.
C1 [Cohen, Stacey A.; McMillen, Kerry; Heit, Madilyn; Wadhera, Sonia; Daniels, Jonathan; Hansen, Kjell; Jacoby, Madeline; Coveler, Andrew L.; King, Gentry; Purcell, Tom; Safyan, Rachael A.; Shankaran, Veena; Zhen, David B.; Chiorean, E. Gabriela; Greenlee, Heather] Fred Hutchinson Canc Ctr, Clin Res Div, 825 Eastlake Ave E, Seattle, WA 98109 USA.
   [Cohen, Stacey A.; Heit, Madilyn; Wadhera, Sonia; Daniels, Jonathan; Hansen, Kjell; Jacoby, Madeline; Coveler, Andrew L.; Hannan, Lindsay M.; King, Gentry; Purcell, Tom; Safyan, Rachael A.; Shankaran, Veena; Zhen, David B.; Chiorean, E. Gabriela; Greenlee, Heather] Univ Washington, Sch Med, Div Med Oncol, Seattle, WA USA.
   [Veleber, Susan; Siman, Jonathan; Taromina, Katherine; Chin, Samantha; Romeo, Melissa; Langley, Blake O.; Greenlee, Heather] Fred Hutchinson Canc Ctr, Integrat Med Program, Div Support Care, Seattle, WA USA.
   [Veleber, Susan; Siman, Jonathan; Guthrie, Katherine A.; Langley, Blake O.; Greenlee, Heather] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA.
   [Langley, Blake O.] Univ Washington, Dept Child Family & Populat Hlth Nursing, Seattle, WA 98195 USA.
   [Cohen, Stacey A.] 825 Eastlake Ave E,LG-465, Seattle, WA 98109 USA.
C3 Fred Hutchinson Cancer Center; University of Washington; University of
   Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson
   Cancer Center; University of Washington; University of Washington
   Seattle
RP Cohen, SA (corresponding author), 825 Eastlake Ave E,LG-465, Seattle, WA 98109 USA.
EM shiovitz@uw.edu
RI ; Veleber, Susan/AAP-4033-2020; Langley, Blake/GSN-2764-2022
OI Zhen, David/0000-0003-3375-5912; 
FU Safeway Albertsons Early Career Award in Cancer Research; National
   Center for Complementary and Integrative Health (NCCIH) [RT90AT00854];
   National Center for Complementary and Integrative Health [T90AT008544]
   Funding Source: NIH RePORTER
FX This work was supported by a Safeway Albertsons Early Career Award in
   Cancer Research (S.A.C.) . B.O.L. is supported by the National Center
   for Complementary and Integrative Health (NCCIH; RT90AT00854) .
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NR 42
TC 5
Z9 5
U1 3
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD AUG
PY 2023
VL 131
AR 107273
DI 10.1016/j.cct.2023.107273
EA JUN 2023
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA L9RC0
UT WOS:001026559400001
PM 37380021
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Huemer, M
   Jahn-Kuch, D
   Hofmann, G
   Pichler, M
AF Huemer, Matthias
   Jahn-Kuch, Daniela
   Hofmann, Guenter
   Pichler, Martin
TI A case report of immediate effects of acupuncture on neuropathic cancer
   breakthrough pain
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Palliative care; Pain management; Acupuncture; Complementary &amp;
   alternative medicine (CAM); Neuropathic pain; Cancer pain
AB Introduction: Acupuncture is a promising treatment for visceral cancer pain, but to date, evidence for immediate effects on neuropathic pain is limited. Case presentation: This report presents a case of immediate pain relief by single-needle acupuncture on opioidrefractory neuropathic breakthrough pain in a 78-year-old female breast cancer patient with cervical bone metastases. Acupuncture was applied at a single point neuroanatomically correlating to the pain affected spinal segment. Discussion: Immediately after acupuncture, the patient reported a complete pain relief lasting for one day. In the following days, neuropathic breakthrough pain was better manageable with reduced dosages of opioids. Acupuncture is possibly effective in providing immediate and safe pain relief in neuropathic cancer pain through neuromodulating effects on the spinal and central nervous level. Randomized controlled studies with individualized acupuncture point protocols are needed to establish efficacy and safety.
C1 [Huemer, Matthias; Jahn-Kuch, Daniela; Hofmann, Guenter] Med Univ Graz, Dept Internal Med, Div Oncol, Palliat Care Unit, Graz, Austria.
   [Pichler, Martin] Med Univ Graz, Dept Internal Med, Div Oncol, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz
RP Pichler, M (corresponding author), Med Univ Graz, Dept Internal Med, Div Oncol, Graz, Austria.
EM martin.pichler@medunigraz.at
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NR 11
TC 3
Z9 4
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD AUG
PY 2022
VL 48
AR 101599
DI 10.1016/j.ctcp.2022.101599
EA MAY 2022
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 1T8GW
UT WOS:000804965400007
PM 35584602
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zhang, QX
   Zhou, MM
   Huo, MZ
   Si, YX
   Zhang, YL
   Fang, YX
   Zhang, D
AF Zhang, Qingxiang
   Zhou, Mengmeng
   Huo, Mingzhu
   Si, Yuxin
   Zhang, Youlin
   Fang, Yuxin
   Zhang, Di
TI Mechanisms of acupuncture-electroacupuncture on inflammatory pain
SO MOLECULAR PAIN
LA English
DT Review
DE Acupuncture; analgesia; central nerve system; inflammatory pain;
   peripheral nerve system
ID RECEPTOR POTENTIAL V1; TOLL-LIKE RECEPTORS; BONE CANCER PAIN;
   SPINAL-CORD; NEUROPATHIC PAIN; PROTEIN-KINASE; MOUSE MODEL; SYNAPTIC
   PLASTICITY; PATHOLOGICAL PAIN; GLIAL ACTIVATION
AB Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And 16 of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.
C1 [Zhang, Qingxiang; Zhou, Mengmeng; Huo, Mingzhu; Si, Yuxin; Zhang, Youlin; Fang, Yuxin] Tianjin Univ Tradit Chinese Med, Coll Acumox & Tuina, Res Ctr Expt Acupuncture Sci, Tianjin, Peoples R China.
   [Zhang, Di] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin, Peoples R China.
   [Zhang, Di] Haihe Lab Modern Chinese Med, Tianjin, Peoples R China.
   [Fang, Yuxin] Tianjin Univ Tradit Chinese Med, Coll Acumox & Tuina, Res Ctr Expt Acupuncture Sci, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.
   [Zhang, Di] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.
   [Zhang, Di] Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine; Tianjin University of Traditional Chinese Medicine
RP Fang, YX (corresponding author), Tianjin Univ Tradit Chinese Med, Coll Acumox & Tuina, Res Ctr Expt Acupuncture Sci, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.; Zhang, D (corresponding author), Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.; Zhang, D (corresponding author), Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
EM meng99_2006@126.com; 43987073@qq.com
RI ; Zhang, Qingxiang/IAQ-9890-2023
OI 张, 庆祥/0000-0002-4610-4409; 
FU National Natural Science Foundation of China (NSFC); Natural Science
   Foundation of Tianjin [81973944, 20JCYBJC00200]; Youth Talent Promotion
   Project of the Tianjin Association for Science and Technology
   [22JCYBJC00990];  [TJSQNTJ-2020-15]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Natural Science Foundation of China (NSFC)
   No. 81973944, the Natural Science Foundation of Tianjin No.20JCYBJC00200
   and No.22JCYBJC00990, Youth Talent Promotion Project of the Tianjin
   Association for Science and Tech-nology No. TJSQNTJ-2020-15.
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NR 146
TC 37
Z9 40
U1 7
U2 44
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD SEP
PY 2023
VL 19
AR 17448069231202882
DI 10.1177/17448069231202882
PG 22
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA S2OH7
UT WOS:001069610400001
PM 37678839
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Klose, P
   Kuemmel, S
   Voiss, P
AF Klose, Petra
   Kummel, S.
   Voiss, P.
TI Traditional Chinese medicine in integrative oncology
SO ONKOLOGIE
LA German
DT Article
DE Acupuncture; Acupressure; Cancer; TCM; Integrative oncology
ID CHEMOTHERAPY-INDUCED NAUSEA; BREAST-CANCER SURVIVORS; HOT FLASHES;
   ACUPUNCTURE; TRIAL; ACUPRESSURE; EFFICACY; FATIGUE
AB Therapies from traditional Chinese medicine (TCM) are increasingly being integrated into western treatment concepts within the framework of integrative oncology. The focus is on reducing the side effects of oncological treatment, improving the quality of life, promoting a healthy lifestyle and strengthening and harmonizing the patient. There is good evidence for a number of TCM procedures, especially for acupuncture/acupressure to relieve pain (caused by chemotherapy, aromatase inhibitors or the cancer itself). Sleep, cognition and menopausal symptoms can also be improved by acupuncture/acupressure. Ginseng for fatigue and ginger for nausea can be tried as single drugs. Evidence-based medicine has also driven research in TCM, and methodologically high-quality study results are now available that are worthy of critical consideration.
C1 [Klose, Petra; Kummel, S.; Voiss, P.] KEM Evang Kliniken Essen Mitte, Klin Nat Heilkunde & Integrat Med, Deimelsberg 34a, D-45276 Essen, Germany.
   [Kummel, S.; Voiss, P.] KEM Evang Kliniken Essen Mitte, Klin Senol Interdisziplinares Brustkrebszentrum, Essen, Germany.
RP Klose, P (corresponding author), KEM Evang Kliniken Essen Mitte, Klin Nat Heilkunde & Integrat Med, Deimelsberg 34a, D-45276 Essen, Germany.
EM p.klose@kem-med.com
RI Kuemmel, Sherko/AFV-3420-2022
CR Arbeitsgemeinschaft Gynakologische Onkologie Kommission Mamma, 2021, EMPF GYN ONK KOMM MA
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NR 42
TC 0
Z9 0
U1 1
U2 14
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-7226
EI 2731-7234
J9 ONKOLOGIE-GER
JI Onkologie
PD NOV
PY 2022
VL 28
IS 11
SI SI
BP 1024
EP 1032
DI 10.1007/s00761-022-01234-4
EA SEP 2022
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5V2LC
UT WOS:000859626600001
DA 2026-01-16
ER

PT J
AU Tang, WR
   Chen, WJ
   Yu, CT
   Chang, YC
   Chen, CM
   Wang, CH
   Yang, SH
AF Tang, Woung-Ru
   Chen, Wan-Jung
   Yu, Chih-Teng
   Chang, Yue-Cune
   Chen, Chuan-Mei
   Wang, Chiu-Hua
   Yang, Sien-Hung
TI Effects of acupressure on fatigue of lung cancer patients undergoing
   chemotherapy: An experimental pilot study
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Fatigue; Acupressure; Experimental study; Lung cancer
ID QUALITY-OF-LIFE; SLEEP QUALITY; ACUPOINT STIMULATION; ALTERNATIVE
   MEDICINE; PALLIATIVE CARE; MANAGEMENT; ACUPUNCTURE; DEPRESSION;
   SYMPTOMS; PAIN
AB Background: This study explored the effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy.
   Patients and methods: For this experimental study, 57 subjects were randomly assigned to three groups: acupressure with essential oils (n=17), acupressure only (n=24), and sham acupressure (n=16). Acupoints were Hegu (LI4), Zusanli (ST36), and Sanyingjiao (SP6). All subjects received acupressure once every morning for 5 months, with each acupoint pressed for 1 min. Fatigue, functional status, anxiety, depression, and sleep quality were measured before initial chemotherapy (TO), on Day 1 of third chemotherapy (T1), and on Day 1 of sixth chemotherapy (T2). Outcome differences between groups were analyzed at T0, T1, and T2 by general estimating equations.
   Results: After controlling for baseline outcome values, age, and adherence to acupressure, subjects who received acupressure with essential oils and acupressure had significantly less fatigue in daily living activities and sleep better quality at T1 than subjects who received sham acupressure. Subjects who received acupressure with essential oils had significantly better sleep quality at T2 than the sham acupressure group. Subjects who received acupressure with or without essential oils had greater odds of better functional status at T1 than the sham group.
   Conclusion: It is plausible that acupressure with or without essential oils helps lung cancer patients undergoing chemotherapy reduce cancer-related fatigue and increase activity level. Further study is wanted to test this hypothesis. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Tang, Woung-Ru; Chen, Wan-Jung; Chen, Chuan-Mei; Wang, Chiu-Hua] Chang Gung Univ, Coll Med, Sch Nursing, Taoyuan, Taiwan.
   [Yu, Chih-Teng] Chang Gung Mem Hosp, Dept Thorac Med, Taoyuan, Taiwan.
   [Yu, Chih-Teng] Chang Gung Univ, Coll Med, Sch Med, Taoyuan, Taiwan.
   [Chang, Yue-Cune] Tamkang Univ, Dept Math, Taipei, Taiwan.
   [Yang, Sien-Hung] Chang Guns Mem Hosp, Dept Tradit Chinese Med, Taoyuan, Taiwan.
   [Yang, Sien-Hung] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Tamkang University; Chang Gung University
RP Tang, WR (corresponding author), Chang Gung Univ, Coll Med, Sch Nursing, 259 Wen Hwa 1st Rd, Taoyuan, Taiwan.
EM wtang@mail.cgu.edu.tw
FU National Science Council in Taiwan [NMRPD180821]
FX This work was supported by the National Science Council in Taiwan (grant
   no. NMRPD180821). Special thanks to all the lung cancer patients who
   participated in this research. The time spent with you will be a
   treasured experience in our lives.
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NR 63
TC 58
Z9 64
U1 2
U2 38
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2014
VL 22
IS 4
BP 581
EP 591
DI 10.1016/j.ctim.2014.05.006
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AO6MG
UT WOS:000341465600001
PM 25146059
DA 2026-01-16
ER

PT J
AU Jang, S
   Ko, Y
   Sasaki, Y
   Park, S
   Jo, J
   Kang, NH
   Yoo, ES
   Park, NC
   Cho, SH
   Jang, H
   Jang, BH
   Hwang, DS
   Ko, SG
AF Jang, Soobin
   Ko, Youme
   Sasaki, Yui
   Park, Sunju
   Jo, Junyoung
   Kang, Na-Hoon
   Yoo, Eun-Sil
   Park, Nam-Chun
   Cho, Seong Hee
   Jang, Heejea
   Jang, Bo-Hyoung
   Hwang, Deok-Sang
   Ko, Seong-Gyu
TI Acupuncture as an adjuvant therapy for management of treatment-related
   symptoms in breast cancer patients Systematic review and meta-analysis
   (PRISMA-compliant)
SO MEDICINE
LA English
DT Review
DE acupuncture; complementary and alternative medicine;
   electro-acupuncture; Korean medicine
ID CONTROLLED-TRIAL; ALTERNATIVE MEDICINE; VASOMOTOR SYMPTOMS;
   DOUBLE-BLIND; HOT FLASHES; DUAL-CENTER; WOMEN; COMPLEMENTARY;
   ELECTROACUPUNCTURE; CHEMOTHERAPY
AB Background: Although randomized controlled trials have revealed the considerable effectiveness of acupuncture in breast cancer patients, there have been no studies exploring current acupuncture research trends for treatment induced various symptoms in breast cancer patients. This review evaluated the effectiveness of acupuncture for treatment-induced symptoms in breast cancer patients. Methods: We performed a systematic review and meta-analysis of the literature regarding acupuncture to treat symptoms associated with breast cancer therapies. The following databases were searched for relevant RCTs published before June 2018: MEDLINE, EMBASE, the Cochrane Library, AMED, CINAHL, OASIS, CNKI, and CiNii. Results: Among the 19,483 records identified, 835 articles remained after screening titles and abstracts. A total of 19 RCTs were included in this qualitative synthesis. Among the studies, 8 explored climacteric symptoms, 4 explored pain, 2 explored lymphedemas, 2 explored nausea and vomiting and 3 investigated miscellaneous symptoms. explored miscellaneous symptoms due to cancer treatments. Most of the studies reported that acupuncture can alleviate various symptoms of breast cancer treatment. However, there is a lack of evidence as to whether accupuncture can alleviate chemotherapy associated side effects Conclusions: Acupuncture may alleviate the treatment-related symptoms of breast cancer; however, further studies are necessary to obtain conclusive evidence of the effectiveness of acupuncture in treating breast cancer. Registration number: CRD42018087813
C1 [Jang, Soobin] Korea Inst Oriental Med, Div Clin Res, 1672 Yuseong Daero, Daejeon, South Korea.
   [Ko, Youme; Sasaki, Yui; Jang, Bo-Hyoung; Ko, Seong-Gyu] Kyung Hee Univ, Dept Prevent Med, Coll Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Park, Sunju; Hwang, Deok-Sang] Daejeon Univ, Dept Prevent Med, Coll Korean Med, 62 Daehak Ro, Daejeon, South Korea.
   [Jo, Junyoung] Korean Med, Dept Korean Obstet & Gynecol, Conmaul Hosp, 110 Seochojungang Ro, Seoul, South Korea.
   [Kang, Na-Hoon; Yoo, Eun-Sil; Park, Nam-Chun] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, 26 Kyungheedae Ro, Seoul, South Korea.
   [Cho, Seong Hee] Dong Shin Univ, Dept Obstet & Gynecol, Coll Korean Med, 185 Geonjae Ro, Naju Si, Jeollanam Do, South Korea.
   [Jang, Heejea] Soram Korean Med Hosp, Women Canc Ctr, 154-11 Samsung Dong, Seoul 06154, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM); Kyung Hee University;
   Daejeon University; Kyung Hee University
RP Jang, BH (corresponding author), Kyung Hee Univ, Dept Prevent Med, Coll Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.; Hwang, DS (corresponding author), Daejeon Univ, Dept Prevent Med, Coll Korean Med, 62 Daehak Ro, Daejeon, South Korea.
EM bhjang@khu.ac.kr
RI ; Jang, Soobin/ODN-1434-2025
OI Sasaki, Yui/0000-0002-4057-9294; Jang, Soobin/0000-0003-0943-9290
FU Traditional Korean Medicine RAMP;D Program - Ministry of Health AMP;
   Welfare through the Korea Health Industry Development Institute (KHIDI)
   [HB16C0072]
FX This study was supported by the Traditional Korean Medicine R&D Program
   funded by the Ministry of Health & Welfare through the Korea Health
   Industry Development Institute (KHIDI) (HB16C0072). The funding source
   had no influence in the design of the study, analysis, interpretation of
   the data, and writing the manuscript.
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NR 45
TC 20
Z9 30
U1 2
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 11
PY 2020
VL 99
IS 50
AR e21820
DI 10.1097/MD.0000000000021820
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6GU
UT WOS:000612838800003
PM 33327222
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tas, D
   Uncu, D
   Sendur, MA
   Koca, N
   Zengin, N
AF Tas, Demet
   Uncu, Dogan
   Sendur, Mehmet Ali
   Koca, Nuran
   Zengin, Nurullah
TI Acupuncture as a Complementary Treatment for Cancer Patients Receiving
   Chemotherapy
SO ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE Acupuncture; cancer; chemotherapy; nausea; insomnia; anxiety; vomiting;
   pain; Turkey
ID INSOMNIA SEVERITY INDEX; BREAST-CANCER; ANXIETY; NAUSEA; PAIN;
   ELECTROACUPUNCTURE; STIMULATION; MOXIBUSTION; FATIGUE; WOMEN
AB Background: Medical treatment for eliminating the side effects of cancer therapy may not always be efficacious. Acupuncture is one of the most widely accepted alternative and complementary therapies in use today. In this study, we investigated the efficacy of acupuncture in patients experiencing cancer treatment side effects, including nausea, vomiting, pain, poor sleep quality and anxiety. Materials and Methods: A total of 45 inpatients who underwent chemotherapy between February and April 2013 in the Oncology Department of Numune Hospital were included in our study. Acupuncture was administered to the patients one day prior to chemotherapy, on the day of chemotherapy and one day after chemotherapy. The patients were evaluated on nausea, vomiting, pain, sleep quality and anxiety before the chemotherapy and on the 4th day of chemotherapy. Results: Of the 45 patients included in the study, 18 (40%) were female and 27 (60%) were male. A total of 25 (55.6%) had an elementary school education; 32 patients (71%) had stage 4 cancer and were treated with palliative chemotherapy (the patient characteristics are shown in Table 1). Statistically significant decreases (p<0.001) in pain, nausea, vomiting, insomnia and anxiety scores were observed after the acupuncture treatment compared to baseline. There were no differences in the age, gender, education level, stage or metastasis levels between the patient groups whose symptoms improved or were unchanged. Conclusions: Our study showed that acupuncture has positive effects in cancer treatment patients who experience nausea, vomiting, pain, poor sleep quality and anxiety as side effects of chemotherapy. Chemotherapy-related side effects in cancer patients could be decreased by the concurrent use of acupuncture.
C1 [Tas, Demet] Minist Hlth, Tradit Complementary & Alternat Med Dept, Ankara, Turkey.
   [Uncu, Dogan; Sendur, Mehmet Ali; Koca, Nuran; Zengin, Nurullah] Ankara Numune Training & Res Hosp, Med Oncol Clin, Ankara, Turkey.
C3 Ministry of Health - Turkey; Ankara Numune Training & Research Hospital
RP Tas, D (corresponding author), Minist Hlth, Tradit Complementary & Alternat Med Dept, Ankara, Turkey.
EM demettas19691@hotmail.com
RI Sendur, Mehmet/H-7555-2014; Tas, Demet/AAF-7171-2019; Zengin,
   Nurullah/KBQ-0049-2024
OI Sendur, Mehmet/0000-0001-7021-6139; 
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
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NR 35
TC 21
Z9 23
U1 0
U2 42
PU ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
PI GYEONGGI-DO
PA APJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO,
   ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO, 410-769, SOUTH KOREA
SN 1513-7368
J9 ASIAN PAC J CANCER P
JI Asian Pac. J. Cancer Prev.
PY 2014
VL 15
IS 7
BP 3139
EP 3144
DI 10.7314/APJCP.2014.15.7.3139
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AI4KQ
UT WOS:000336834500033
PM 24815460
OA gold
DA 2026-01-16
ER

PT J
AU Wang, HZ
   Qu, SY
   Zhou, TS
   Hu, QQ
   Zhao, XX
   Yang, QJ
   Chi, HY
   Luo, SL
   Li, XY
   Ke, HX
   He, XF
   Zhao, HL
   Zhao, HL
AF Wang, Hanzhi
   Qu, Siying
   Zhou, Tianshu
   Hu, Qunqi
   Zhao, Xiaoxuan
   Yang, Qujia
   Chi, Hengyu
   Luo, Shiling
   Li, Xinyue
   Ke, Huanxiao
   He, Xiaofen
   Zhao, Hongli
   Zhao, Hongli
TI Current Perspectives and Trend of Acupuncture in Breast Cancer-Related
   Symptoms: A Bibliometric Study
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE breast cancer-related symptoms; acupuncture; bibliometric study; cancer
   pain; CiteSpace; VOSviewer
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; JOINT PAIN;
   CHEMOTHERAPY; WOMEN; ELECTROACUPUNCTURE; THERAPY; RECOMMENDATIONS;
   PREVENTION; MANAGEMENT
AB Purpose: This bibliometric research aims to delineate global publication trends and emerging research interests in the use of acupuncture for breast cancer (BC)-related symptoms treatment over the past three decades. Furthermore, it identifies influential institutions, potential collaborative partners, and future research trends, thereby providing guidance for relevant, novel research directions. Methods: Scientific publications related to acupuncture for BC-related symptoms were gathered from the Web of Science Core Collection (WoSCC) from 1993 to 2023. Four software applications were principally used to analyze the resulting data: the "bibliometrix" package in the R environment (version 4.2.3), VOSviewer, CiteSpace6.1.R6, and the bibliometrics website. These applications were employed to evaluate different parameters. Results: A total of 621 papers on acupuncture in BC-related symptoms treatment were analyzed. The United States, China, and South Korea contributed the most, with Memorial Sloan Kettering Cancer Center, and Columbia University leading institutions. It is interesting to mention that Mao, Jun J. and Molassiotis, A. feature among the top 10 authors and co-cited authors. JAMA is the leading journal, with an ongoing focus on acupuncture's effectiveness. Keywords show that the initial research focus was mainly on "vasomotor symptoms", but in recent years there has been a gradual shift towards "pain", "chemotherapy-induced peripheral neuropathy (CIPN)", "electroacupuncture", and "non-specific effects". Conclusion: Acupuncture has demonstrated a unique value in the process of adjuvant treatment of BC-related symptoms, and has been shown to be effective in reducing pain, eliminating fatigue, and improving quality of life. The study of the mechanisms of acupuncture and the application of electroacupuncture are possible future research priorities in this field. This study offers a deep perspective on acupuncture for BC research, highlighting key points and future trends.
C1 [Wang, Hanzhi; Zhao, Xiaoxuan; Yang, Qujia; Luo, Shiling; Ke, Huanxiao; Zhao, Hongli; Zhao, Hongli] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Dept Tradit Chinese Med TCM Gynecol, 453 Tiyuchang Rd, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Hanzhi; Qu, Siying; Hu, Qunqi; Yang, Qujia; Chi, Hengyu; Ke, Huanxiao] Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China.
   [Zhou, Tianshu] Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China.
   [Li, Xinyue] Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [He, Xiaofen] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Wenzhou Medical University; Zhejiang University; Zhejiang
   Chinese Medical University
RP Zhao, HL (corresponding author), Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Dept Tradit Chinese Med TCM Gynecol, 453 Tiyuchang Rd, Hangzhou, Zhejiang, Peoples R China.; He, XF (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou, Zhejiang, Peoples R China.
EM zjhxf1986@163.com; z6hl@163.com
RI ; Qu, Siying/OTI-2971-2025; Zhao, Hongli/OJU-4239-2025; Hu,
   Qunqi/HRD-3345-2023
OI Wang, Hanzhi/0009-0003-7867-0864; 
FU National Natural Science Foundation of China [81804181]; Hangzhou
   Science and Technology Development Plan Project [202004A13]
FX Funding This research was supported by the National Natural Science
   Foundation of China (No. 81804181) and the Hangzhou Science and
   Technology Development Plan Project (No. 202004A13) .
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NR 64
TC 5
Z9 5
U1 2
U2 32
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 4165
EP 4180
DI 10.2147/JPR.S442151
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AL3L8
UT WOS:001118580500001
PM 38078016
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Azad, A
   John, T
AF Azad, Arun
   John, Thomas
TI Do Randomized Acupuncture Studies in Patients With Cancer Need a Sham
   Acupuncture Control Arm?
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Letter
ID RADIATION-INDUCED XEROSTOMIA; LOW-BACK-PAIN; CONTROLLED-TRIAL;
   BREAST-CANCER; AURICULAR ACUPUNCTURE; PLACEBO-ACUPUNCTURE; INDUCED
   NAUSEA; HOT FLASHES; CHEMOTHERAPY; ELECTROACUPUNCTURE
C1 [Azad, Arun] Austin Hlth, Joint Austin Ludwig Oncol Unit, Melbourne, Vic, Australia.
   Austin Hlth, Ludwig Inst Canc Res, Melbourne, Vic, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Florey Institute of Neuroscience & Mental Health;
   Howard Florey Institute Affiliates; Austin Research Institute; Ludwig
   Institute for Cancer Research
RP Azad, A (corresponding author), Austin Hlth, Joint Austin Ludwig Oncol Unit, Melbourne, Vic, Australia.
RI John, Thomas/HNJ-1606-2023
OI John, Thomas/0000-0003-3399-5342; Azad, Arun/0000-0001-7350-5622
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NR 29
TC 13
Z9 14
U1 1
U2 28
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD JUN 1
PY 2013
VL 31
IS 16
BP 2057
EP 2058
DI 10.1200/JCO.2012.47.8750
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 154FP
UT WOS:000319657600032
PM 23610109
DA 2026-01-16
ER

PT J
AU Krukowska, K
   Krzyskowska, S
   Kuchta, E
   Rudzinska, A
   Szklener, K
   Mandziuk, S
AF Krukowska, Kamila
   Krzyskowska, Sylwia
   Kuchta, Eliza
   Rudzinska, Anna
   Szklener, Katarzyna
   Mandziuk, Slawomir
TI The effectiveness of acupuncture in cancer pain treatment
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE acupuncture; pain management; cancer pain; quality of life;
   complementary medicine
ID QUALITY-OF-LIFE; GASTRIC-CANCER; POSTOPERATIVE ILEUS; LUNG-CANCER;
   SYMPTOMS; GASTRECTOMY; SURGERY
AB Introduction In recent years, pain has been recognized as a primary factor significantly diminishing the quality of life in cancer patients. Recent data have prompted the establishment and increased application of non-pharmacological interventions in pain management, such as acupuncture.Objectives This review assesses literature from 2018 to 2023 on the impact of acupuncture on pain management and quality of life in cancer patients, with a particular focus on reducing pain intensity. The effectiveness of acupuncture therapy was compared with the traditional treatment of pain symptoms, with a focus on the patients' quality of life.Conclusions Although no conclusive scientific evidence confirms the effectiveness of acupuncture in treating cancer pain symptoms, numerous studies have demonstrated its ability to reduce pain, better control pain, decrease analgesic intake, and significantly improve patients' quality of life. Further research is needed to unequivocally confirm the clinical benefits of acupuncture.
C1 [Krukowska, Kamila; Krzyskowska, Sylwia; Kuchta, Eliza; Rudzinska, Anna; Szklener, Katarzyna; Mandziuk, Slawomir] Med Univ Lublin, Dept Clin Oncol & Chemotherapy, Lublin, Poland.
C3 Medical University of Lublin
RP Krukowska, K (corresponding author), Med Univ Lublin, Dept Clin Oncol & Chemotherapy, Lublin, Poland.
EM kamila.krukowska@onet.pl
RI Szklener, Katarzyna/AAB-3234-2022
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NR 53
TC 2
Z9 2
U1 4
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD NOV 21
PY 2024
VL 14
AR 1450105
DI 10.3389/fonc.2024.1450105
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O3I6Z
UT WOS:001370112200001
PM 39640281
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huang, JH
   Zhao, LY
   Xie, YF
   Wang, C
   Yang, XJ
   Huang, HF
   Zhang, D
AF Huang, Jianhao
   Zhao, Liuyang
   Xie, Yufeng
   Wang, Chi
   Yang, Xinjing
   Huang, Haifu
   Zhang, Dian
TI Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain:
   Insights From Multimodal Bioelectrical Signal Analysis
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE cancer pain; acupuncture; multimodal bioelectrical signals; analgesic
   mechanism; deep learning
AB Purpose: Cancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis. Patients and Methods: Fifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neurophysiological changes were evaluated using Principal Component Analysis, Joint Time-Frequency Analysis, power spectrum analysis, spectral analysis, and dynamic functional network analysis. Results: There was a significant reduction in NRS scores from pre-treatment to the retention period, indicating pain relief. Principal component analysis showed significant differences in bioelectrical signals between these periods. Power spectrum analysis revealed decreased signal power during retention. Functional network analysis demonstrated a reduction in connectivity strength between electroencephalography and electromyography signals. Spectral analysis identified distinct real-time and staged characteristics of bioelectrical signals, with correlation analysis confirming a positive relationship between NRS score changes and bioelectrical signal alterations. Conclusion: Acupuncture alleviates cancer pain by reducing functional connectivity between injured tissues and the brain, with immediate effects. Prolonging needle retention may enhance therapeutic outcomes. These findings provide new insights into the neurophysiological basis of acupuncture's analgesic effects, supporting its role in cancer pain management.
C1 [Huang, Jianhao; Xie, Yufeng; Yang, Xinjing; Huang, Haifu] Guangzhou Univ Chinese Med, Shenzhen Hosp Fu Tian, Dept Acupuncture & Moxibust, Shenzhen, Peoples R China.
   [Zhao, Liuyang; Zhang, Dian] Shenzhen Univ, Sch Comp & Software, 3688,Nanhai Ave, Shenzhen, Peoples R China.
   [Xie, Yufeng] Macau Univ Sci & Technol, Fac Chinese Med, Taipa, Macao, Peoples R China.
   [Xie, Yufeng] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
   [Wang, Chi] Ganzhou Tradit Chinese Med Hosp, Ganzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Shenzhen University; Macau
   University of Science & Technology; Macau University of Science &
   Technology
RP Zhang, D (corresponding author), Shenzhen Univ, Sch Comp & Software, 3688,Nanhai Ave, Shenzhen, Peoples R China.; Huang, HF (corresponding author), Guangzhou Univ Chinese Med, Shenzhen Hosp Fu Tian, 6001 Beihuan Ave, Futian Dist, Shenzhen, Peoples R China.
EM huanghaifu2004@163.com; zhangd@szu.edu.cn
FU Shenzhen Science and Technology Program Fund [JCYJ20220531091407016];
   Futian Healthcare Research Project [FTWS069, FTWS055]
FX Funding This work was supported by the Shenzhen Science and Technology
   Program Fund (JCYJ20220531091407016) ; and Futian Healthcare Research
   Project (FTWS069; FTWS055) .
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NR 35
TC 1
Z9 1
U1 3
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2025
VL 18
BP 1435
EP 1450
DI 10.2147/JPR.S503975
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0LD6G
UT WOS:001449974500001
PM 40130202
OA gold
DA 2026-01-16
ER

PT J
AU Wang, Y
   Lei, JX
   Gupta, M
   Peng, F
   Lam, S
   Jha, R
   Raduenz, E
   Beitz, AJ
   Gupta, K
AF Wang, Ying
   Lei, Jianxun
   Gupta, Mihir
   Peng, Fei
   Lam, Sarah
   Jha, Ritu
   Raduenz, Ellis
   Beitz, Al J.
   Gupta, Kalpna
TI Electroacupuncture in conscious free-moving mice reduces pain by
   ameliorating peripheral and central nociceptive mechanisms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SICKLE-CELL-DISEASE; HIGH-FREQUENCY ELECTROACUPUNCTURE; OPIOID
   RECEPTORS; ESTROUS-CYCLE; SUBSTANCE-P; CANCER PAIN; SPINAL MICROGLIA;
   BETA-ENDORPHIN; FEMALE RATS; ACUPUNCTURE
AB Integrative approaches such as electroacupuncture, devoid of drug effects are gaining prominence for treating pain. Understanding the mechanisms of electroacupuncture induced analgesia would benefit chronic pain conditions such as sickle cell disease (SCD), for which patients may require opioid analgesics throughout life. Mouse models are instructive in developing a mechanistic understanding of pain, but the anesthesia/restraint required to administer electroacupuncture may alter the underlying mechanisms. To overcome these limitations, we developed a method to perform electroacupuncture in conscious, freely moving, unrestrained mice. Using this technique we demonstrate a significant analgesic effect in transgenic mouse models of SCD and cancer as well as complete Freund's adjuvant-induced pain. We demonstrate a comprehensive antinociceptive effect on mechanical, cold and deep tissue hyperalagesia in both genders. Interestingly, individual mice showed a variable response to electroacupuncture, categorized into high-, moderate-, and non-responders. Mechanistically, electroacupuncture significantly ameliorated inflammatory and nociceptive mediators both peripherally and centrally in sickle mice correlative to the antinociceptive response. Application of sub-optimal doses of morphine in electroacupuncture-treated moderate-responders produced equivalent antinociception as obtained in high-responders. Electroacupuncture in conscious freely moving mice offers an effective approach to develop a mechanism-based understanding of analgesia devoid of the influence of anesthetics or restraints.
C1 [Wang, Ying; Lei, Jianxun; Peng, Fei; Lam, Sarah; Jha, Ritu; Raduenz, Ellis; Gupta, Kalpna] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Vasc Biol Ctr, 14-100 PWB,516 Delaware ST SE, Minneapolis, MN 55455 USA.
   [Gupta, Mihir] Univ Calif San Diego, Dept Neurosurgery, 200 West Arbor Dr 8893, La Jolla, CA 92103 USA.
   [Beitz, Al J.] Univ Minnesota, Dept Vet & Biomed Sci, 295 Anim Sci Vet Med Bldg,1988 Fitch Ave, St Paul, MN 55108 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of California System; University of California San Diego;
   University of Minnesota System; University of Minnesota Twin Cities
RP Wang, Y (corresponding author), Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Vasc Biol Ctr, 14-100 PWB,516 Delaware ST SE, Minneapolis, MN 55455 USA.
EM wang5729@umn.edu; gupta014@umn.edu
OI Beitz, Alvin/0000-0002-2640-2628
FU NIH [RO1 103773, UO1 HL117664]; Institute for Engineering in Medicine
FX This study is supported by NIH RO1 103773 and UO1 HL117664 and Institute
   for Engineering in Medicine grants to K.G. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. The authors thank
   Michael Franklin and Barb Benson for assistance with manuscript editing;
   Michael Weston for technical assistance; Susie Thompson for breeding,
   genotyping, and phenotyping mice; Deniz Ercan-Fang for assistance with
   experiments.
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NR 98
TC 15
Z9 17
U1 1
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 30
PY 2016
VL 6
AR 34493
DI 10.1038/srep34493
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DX3RW
UT WOS:000384291600001
PM 27687125
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jiao, LB
   He, XX
   Zhang, JH
   Liu, YL
   Luo, YA
   Wei, H
AF Jiao, Liangbo
   He, Xiaoxia
   Zhang, Jihong
   Liu, Yali
   Luo, Yanan
   Wei, Hu
TI Effects of Acupuncture on Cancer Pain in Animal Intervention Studies: A
   Systematic Review and Quality Assessment
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; methodological and reporting quality; cancer pain; SYRCLE;
   ARRIVE
ID ELECTROACUPUNCTURE; EXPRESSION
AB Background: Preclinical studies often provide the evidence base for clinical studies. However, the design and reporting of preclinical trial results are inadequate, resulting in poor reproducibility and clinical translatability. We aimed to systematically evaluate the methodology and reporting quality of animal studies of acupuncture for cancer pain. Methods: About 7 databases were searched for animal research articles on acupuncture for cancer pain from the beginning of the database to January 31, 2022. ARRIVE guidelines, STRICTA, and SYRCLE risk of bias tools were used to assess the reporting quality and risk of bias of the selected studies. Results: A total of 18 studies were evaluated. Of the 22 items on the SYRCLE tool, only 6 items had a positive reporting rate of more than 50%. Of the 39 items in the ARRIVE guidelines, 14 were rated excellent, and the least frequently reported checklist items were 7. Out of the 17 STRICTA checklist items analyzed, 10 were considered appropriately reported in more than 80% of the studies, while 4 were correctly reported in less than 20%. Conclusions: Some crucial points in the design, implementation, and reporting of the experiments included in the study were not well developed, which could significantly affect the clarity, reproducibility, and translatability of the experiments. There is a need to fully implement scientific tool guidelines for future experimental studies in order to improve the quality of preclinical studies and facilitate effective translation of their results to the clinic.
C1 [Jiao, Liangbo; Zhang, Jihong] China Three Gorges Univ, Peoples Hosp 2, Yichang, Hubei, Peoples R China.
   [He, Xiaoxia; Liu, Yali; Luo, Yanan; Wei, Hu] China Three Gorges Univ, Third Grade Pharmacol Lab Chinese Med, Med Coll, State Adm Tradit Chinese Med, Yichang, Hubei, Peoples R China.
C3 China Three Gorges University; China Three Gorges University
RP Luo, YA; Wei, H (corresponding author), China Three Gorges Univ, Med Coll, Third Grade Pharmacol Lab Chinese Med, 8 Univ Rd, Yichang 443002, Hubei, Peoples R China.
EM luoyanan@ctgu.edu.cn; huwei@ctgu.edu.cn
RI ; jiao, liangbo/GYU-7280-2022
OI He, Xiaoxia/0000-0001-7926-9448; 
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NR 35
TC 0
Z9 0
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD OCT
PY 2022
VL 21
AR 15347354221123788
DI 10.1177/15347354221123788
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 6L4ME
UT WOS:000888157400001
PM 36314416
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, MX
   Baser, RE
   Liou, KT
   Li, SQ
   Piulson, L
   Panageas, KS
   Mao, JJ
AF Yang, Mingxiao
   Baser, Raymond E.
   Liou, Kevin T.
   Li, Susan Q.
   Piulson, Lauren
   Panageas, Katherine S.
   Mao, Jun J.
TI Effect of acupuncture versus usual care on sleep quality in cancer
   survivors with chronic pain: Secondary analysis of a randomized clinical
   trial
SO CANCER
LA English
DT Article
DE cancer survivor; chronic pain; clinical trial; integrative care; sleep
   disturbance
ID INSOMNIA; DISTURBANCE; ADULTS; MEDICATION; MANAGEMENT; EFFICACY;
   THERAPY; FATIGUE
AB BackgroundChronic pain negatively affects sleep; it is unclear whether pain relief from acupuncture contributes to sleep quality improvements in cancer survivors. This study aimed to evaluate the effect of acupuncture versus usual care on sleep quality among cancer survivors with comorbid sleep disturbance and chronic musculoskeletal pain. MethodsSleep outcome data from the Personalized Electroacupuncture Versus Auricular Acupuncture Comparative Effectiveness (PEACE) randomized clinical trial were analyzed. Electroacupuncture or auricular acupuncture was compared with usual care for sleep quality improvement over 10 weeks of treatment among cancer survivors with clinically significant sleep disturbance and chronic musculoskeletal pain at baseline. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) global score. ResultsAmong 268 participants (mean [standard deviation (SD)] age, 61.4 [12.6] years; 191 women [71.3%]; mean [SD] baseline PSQI global score, 10.3 [3.3] points), electroacupuncture and auricular acupuncture resulted in greater reductions in the PSQI global score from baseline to 10 weeks in comparison with usual care: 1.42 points (95% confidence interval [CI], 0.45-2.38; p = .004) and 1.59 points (95% CI, 0.62-2.55; p = .001), respectively. The improvement in sleep quality for the acupuncture groups was sustained for 24 weeks from randomization. Furthermore, a greater proportion of patients in the electroacupuncture and auricular acupuncture groups had clinically meaningful improvement in sleep quality compared to the usual care group (41.0% and 42.9% vs. 21.4%; p = .044). ConclusionsAmong cancer survivors with comorbid sleep disturbance and chronic pain, electroacupuncture and auricular acupuncture produced a clinically relevant and persistent improvement in sleep quality. These findings suggest that acupuncture may be an evidence-based nonpharmacologic intervention to improve sleep health for cancer survivors with pain. Plain Language Summary This study analyzed the sleep quality data from a published randomized clinical trial that evaluated the effect of electroacupuncture or auricular acupuncture versus usual care on pain relief among people who survived cancer.This analysis included a prespecified subgroup of 268 participants with co-occurring sleep disturbance and chronic musculoskeletal pain at baseline and found that patients who used acupuncture for pain relief demonstrated greater improvements in sleep quality compared with patients who received usual care.Sleep quality improvement by acupuncture was sustained after the treatment ended.
C1 [Yang, Mingxiao; Liou, Kevin T.; Li, Susan Q.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY USA.
   [Baser, Raymond E.; Piulson, Lauren; Panageas, Katherine S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St, New York, NY 10065 USA.
EM maoj@mskcc.org
RI ; Yang, Mingxiao/ABF-6416-2021
OI Mao, Jun/0000-0001-9229-0380; Yang, Mingxiao/0000-0002-6514-3366; Liou,
   Kevin/0000-0002-2438-9749
FU National Institutes of Health/National Cancer Institute [R01CA240417];
   US Department of Defense;  [P30 CA008748];  [W81XWH-15-1-0245]; National
   Cancer Institute [K08CA266927, R01CA240417, P30CA008748] Funding Source:
   NIH RePORTER
FX National Institutes of Health/National Cancer Institute, Grant/Award
   Numbers: P30CA008748, R01CA240417; US Department of Defense, Grant/Award
   Number: W81XWH-15-1-0245
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NR 50
TC 14
Z9 14
U1 2
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD JUL 1
PY 2023
VL 129
IS 13
BP 2084
EP 2094
DI 10.1002/cncr.34766
EA MAR 2023
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA I9YJ4
UT WOS:000966652400001
PM 36989257
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Wan, QY
   Chen, H
   Wang, XQ
   Xi, HQ
   Zheng, SY
   Luo, ST
   Wu, WZ
   Pan, R
AF Wan, Qingyun
   Chen, Hao
   Wang, Xiaoqiu
   Xi, Hanqing
   Zheng, Shiyu
   Luo, Shuting
   Wu, Wenzhong
   Pan, Rui
TI Effectiveness of different acupuncture therapies for chronic cancer pain
   A protocol for systematic review and Bayesian network meta-analysis
SO MEDICINE
LA English
DT Review
DE a systematic review; acupuncture; chronic cancer pain; network
   meta-analysis
ID INCONSISTENCY; QUALITY
AB Background: Pain is a common and distressing symptom experienced by cancer patients. Previous research found acupuncture was associated with significant reductions in pain intensity and opioid use. Acupuncture therapies are various, and the difference in efficacy and safety has never been assessed. This paper aims to assess and rank the effectiveness of the different acupuncture methods and provide an acupuncture treatment guideline for relieving chronic pain in cancer survivors. Methods: Four English databases (PubMed, Embase, Cochrane library, and Web of Science) and 4 Chinese databases (China National Knowledge Infrastructure, Wanfang Data, and Chinese Biomedical Literature Database) will be searched for randomized controlled trials (RCTs) published from the database inception to November 30, 2021. The primary outcomes will be patient-reported pain intensity measured by the Brief Pain Inventory, Visual Analog Scale, Verbal Rating Scale, Numerical Rating Scale, and other valid outcome measures. The Grading of Recommendations Assessment, and Development and Evaluation System will evaluate the quality of evidence. Bayesian network meta-analysis will be performed in WinBUGS V.1.4.3 to determine the comparative effectiveness of the acupuncture therapies. Results: This study will quantify the effectiveness of each acupuncture intervention for chronic cancer pain with pain scores and the use of analgesics. The adverse events of acupuncture treatment for cancer pain will also be reported. Conclusion: The conclusion of our study will help physicians and patients choose suitable acupuncture methods to manage cancer pain.
C1 [Wan, Qingyun; Wang, Xiaoqiu; Xi, Hanqing; Zheng, Shiyu; Luo, Shuting; Wu, Wenzhong] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Nanjing, Peoples R China.
   [Chen, Hao] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
   [Pan, Rui] Nanjing Med Univ, Jiangsu Canc Hosp, Affiliated Canc Hosp, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing Medical University
RP Wu, WZ (corresponding author), Nanjing Univ Chinese Med, Dept Acupuncture & Rehabil, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM maerta_zhongacu@163.com
RI Zheng, Shiyu/KBD-3842-2024
FU key research and development program of Jiangsu Province [BE2021751];
   Nursing Advantage Discipline Project of Nanjing University of Chinese
   Medicine [2019YSHL091]
FX This study was supported key research and development program of Jiangsu
   Province (BE2021751) and Nursing Advantage Discipline Project of Nanjing
   University of Chinese Medicine (NO. 2019YSHL091) (all awarded to
   Wenzhong Wu).
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NR 27
TC 0
Z9 1
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 28
PY 2022
VL 101
IS 4
AR e27965
DI 10.1097/MD.0000000000027965
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YP0YM
UT WOS:000748355900070
PM 35089187
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, YY
   Wang, ST
   Ma, XM
   Yuan, Y
   Cheng, H
   Lin, L
   Tian, L
AF Zhang, Yueyue
   Wang, Shaotong
   Ma, Xiaomin
   Yuan, Yang
   Cheng, Hui
   Lin, Lu
   Tian, Li
TI Massage therapy can effectively relieve cancer pain: A meta-analysis
SO MEDICINE
LA English
DT Review
DE cancer pain; cancer patients; massage therapy; meta-analysis
ID INDUCED PERIPHERAL NEUROPATHY; SYMPTOM CLUSTER; SUPPORTIVE CARE; BACK
   MASSAGE; PREVALENCE; MANAGEMENT; PATIENT; INTERVENTION; REFLEXOLOGY;
   FATIGUE
AB Background:To critically evaluate the effects of massage therapy on cancer pain. Methods:Nine Chinese and English databases (PubMed, Cochrane Library, Embase, SCOPUS, Web of Science core, China Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang, and VIP) were systematically searched from the inception of databases to November 2022 for randomized controlled trials. According to Cochrane Collaboration, 2 reviewers independently assessed the risk of bias and extracted data from the included studies. All analyses were performed with Review Manager 5.4. Results:Thirteen randomized controlled trials were included in the meta-analysis, containing 1000 patients (498 in the massage therapy group and 502 in the control group). Massage therapy could significantly relieve cancer pain in patients (standardized mean difference = -1.16, 95% confidence interval [-1.39, -0.93], P < .00001), especially those in the perioperative period and those with hematological malignancies. Foot reflexology and hand acupressure had a moderate effect on cancer pain relief, with hand acupressure being more effective. Massage duration of 10 to 30 minutes and a program length of & GE;1 week had a better effect and could significantly relieve pain. The occurrence of adverse events was reported in 4 of the 13 studies, all of which were no adverse events. Conclusions:Massage therapy can be used as a complementary alternative therapy to relieve cancer pain in patients with hematological malignancies, breast cancer, and cancers of the digestive system. It is suggested that chemotherapy patients use foot reflexology, and perioperative period patients use hand acupressure. A massage duration of 10 to 30 minutes and a program length of & GE;1 week is recommended to achieve better effects.
C1 [Zhang, Yueyue; Wang, Shaotong; Yuan, Yang; Cheng, Hui; Lin, Lu; Tian, Li] Soochow Univ, Sch Nursing, Suzhou Med Coll, Suzhou, Peoples R China.
   [Zhang, Yueyue; Lin, Lu; Tian, Li] Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China.
   [Ma, Xiaomin] First Peoples Hosp Kunshan, Suzhou, Peoples R China.
   [Tian, Li] Soochow Univ, Sch Nursing, Affiliated Hosp 1, Med Coll, 188 Shizi Rd, Suzhou 215006, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China
RP Tian, L (corresponding author), Soochow Univ, Sch Nursing, Affiliated Hosp 1, Med Coll, 188 Shizi Rd, Suzhou 215006, Peoples R China.
EM 20204231007@stu.suda.edu.cn; 20204231008@stu.suda.edu.cn;
   mxm18913241931@163.com; 20194231009@stu.suda.edu.cn;
   20205231004@stu.suda.edu.cn; linlu@suda.edu.cn; tianlisz@suda.edu.cn
RI Lin, Lu/AAZ-3475-2021
OI , Li/0000-0002-6243-6331
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NR 58
TC 20
Z9 26
U1 2
U2 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 7
PY 2023
VL 102
IS 27
DI 10.1097/MD.0000000000033939
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L8IQ1
UT WOS:001025647200006
PM 37417622
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lee, YC
   Lin, CH
   Hung, SY
   Chung, HY
   Luo, ST
   MacDonald, I
   Chu, YT
   Lin, PL
   Chen, YH
AF Lee, Yu-Chen
   Lin, Chia-Hsien
   Hung, Shih-Ya
   Chung, Hsin-Yi
   Luo, Sih-Ting
   MacDonald, Iona
   Chu, Yu-Ting
   Lin, Pei-Lin
   Chen, Yi-Hung
TI Manual acupuncture relieves bile acid-induced itch in mice: the role of
   microglia and TNF-α
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE acupuncture; pruritogen; microglial activation; spinal cord; cholestatic
   pruritus
ID H-1 RECEPTOR ANTAGONISTS; I HYPERSENSITIVITY ITCH; C-FOS EXPRESSION;
   SCRATCHING BEHAVIOR; NEUROPATHIC PAIN; PROLIFERATION; MINOCYCLINE;
   MODULATION; ACTIVATION; PRURITUS
AB Pruritus, or itch, is a frequent complaint amongst patients with cholestatic hepatobiliary disease and is difficult to manage, with many patients refractory to currently available antipruritic treatments. In this study, we examined whether manual acupuncture (MA) at particular acupoints represses deoxycholic acid (DCA)-induced scratching behavior and microglial activation and compared these effects with those induced by another pruritogen, 5'-guanidinonaltrindole (GNTI, a kappa opioid receptor antagonist). MA at Hegu (LI4) and Quchi (LI11) acupoints significantly attenuated DCA- and GNTI-induced scratching, whereas no such effects were observed at the bilateral Zusanli acupoints (ST36). Interestingly, GNTI-induced scratching was reduced similarly by both MA and electroacupuncture (EA) at the LI4 and LI11 acupoints. MA at non-acupoints did not affect scratching behavior. Intraperitoneal injection of minocycline (a microglial inhibitor) reduced GNTI- and DCA-induced scratching behavior. In Western blot analysis, subcutaneous DCA injection to the back of the neck increased spinal cord expression of ionized calcium-binding adapter molecule 1 (Iba1) and tumor necrosis factor-alpha (TNF-alpha) as compared with saline injection, while MA at LI4 and LI11 reduced these DCA-induced changes. Immunofluorescence confocal microcopy revealed that DCA-induced Iba1 -positive cells with thicker processes emanated from the enlarged cell bodies, while this effect was attenuated by pretreatment with MA. It is concluded that microglia and TNF-alpha play important roles in the itching sensation and MA reduces DCA-induced scratching behavior by alleviating spinal microglial activation. MA may be an effective treatment for cholestatic pruritus.
C1 [Lee, Yu-Chen] China Med Univ Hosp, Dept Acupuncture, Taichung 40402, Taiwan.
   [Lee, Yu-Chen; Chung, Hsin-Yi; Luo, Sih-Ting; MacDonald, Iona; Chu, Yu-Ting; Chen, Yi-Hung] China Med Univ, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan.
   [Lin, Chia-Hsien] Kainan Univ, Dept Hlth Ind Management, 1 Kainan Rd, Taoyuan 33857, Taiwan.
   [Hung, Shih-Ya] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung 40402, Taiwan.
   [Lin, Pei-Lin] Natl Taiwan Univ Hosp, Dept Anesthesiol, Taipei 10002, Taiwan.
   [Chen, Yi-Hung] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
   [Chen, Yi-Hung] Asia Univ, Dept Photon & Commun Engn, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; Kainan University; China
   Medical University Taiwan; National Taiwan University; National Taiwan
   University Hospital; China Medical University Taiwan; Asia University
   Taiwan
RP Chen, YH (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan.; Lin, PL (corresponding author), Natl Taiwan Univ Hosp, Dept Anesthesiol, Taipei 10002, Taiwan.; Chen, YH (corresponding author), China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.; Chen, YH (corresponding author), Asia Univ, Dept Photon & Commun Engn, Taichung, Taiwan.
EM pll5611@ntu.edu.tw; yihungchen@mail.cmu.edu.tw
RI Chen, Yi-Hung/L-8189-2013
FU Ministry of Science and Technology, Taipei, Taiwan
   [MOST104-2320-B-039-020-MY2, 106-2320-B-039-019-]; China Medical
   University Hospital, Taiwan [DMR-106-004]; "Chinese Medicine Research
   Center, China Medical University" from The Featured Areas Research
   Center Program within the framework of the Higher Education Sprout
   Project under the Ministry of Education (MOE) in Taiwan
FX This work was supported by grants MOST104-2320-B-039-020-MY2 and
   106-2320-B-039-019- from the Ministry of Science and Technology, Taipei,
   Taiwan and DMR-106-004 from China Medical University Hospital, Taiwan.
   This work was also financially supported by the "Chinese Medicine
   Research Center, China Medical University" from The Featured Areas
   Research Center Program within the framework of the Higher Education
   Sprout Project under the Ministry of Education (MOE) in Taiwan.
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NR 51
TC 18
Z9 19
U1 0
U2 14
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2018
VL 15
IS 9
BP 953
EP 960
DI 10.7150/ijms.24146
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GM6IH
UT WOS:000438268100012
PM 30008609
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shi, CX
   Liu, Y
   Zhang, W
   Lei, YS
   Lu, CE
   Sun, R
   Sun, YE
   Jiang, M
   Gu, XP
   Ma, ZL
AF Shi, Changxi
   Liu, Yue
   Zhang, Wei
   Lei, Yishan
   Lu, Cui'e
   Sun, Rao
   Sun, Yu'e
   Jiang, Ming
   Gu, Xiaoping
   Ma, Zhengliang
TI Intraoperative electroacupuncture relieves remifentanil-induced
   postoperative hyperalgesia via inhibiting spinal glial activation in
   rats
SO MOLECULAR PAIN
LA English
DT Article
DE Electroacupuncture; postoperative hyperalgesia; remifentanil-induced
   hyperalgesia; glial cells; proinflammatory cytokines; mitogen-activated
   protein kinases
ID OPIOID-INDUCED HYPERALGESIA; RECEPTOR 2B SUBUNIT; CANCER PAIN; TYROSINE
   PHOSPHORYLATION; INTRATHECAL INJECTION; NEUROPATHIC PAIN; MODEL; CORD;
   MECHANISMS; MICROGLIA
AB Background: Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance postoperative pain. Glial cells are thought to be implicated in remifentanil-induced hyperalgesia. Electroacupuncture is a complementary therapy to relieve various pain conditions with few side effects, and glial cells may be involved in its antinociceptive effect. In this study, we investigated whether intraoperative electroacupuncture could relieve remifentanil-induced postoperative hyperalgesia by inhibiting the activation of spinal glial cells, the production of spinal proinflammatory cytokines, and the activation of spinal mitogen-activated protein kinases.
   Methods: A rat model of remifentanil-induced postoperative hyperalgesia was used in this study. Electroacupuncture during surgery was conducted at bilateral Zusanli (ST36) acupoints. Behavior tests, including mechanical allodynia and thermal hyperalgesia, were performed at different time points. Astrocytic marker glial fibrillary acidic protein, microglial marker Iba1, proinflammatory cytokines, and phosphorylated mitogen-activated protein kinases in the spinal cord were detected by Western blot and/or immunofluorescence.
   Results: Mechanical allodynia and thermal hyperalgesia were induced by both surgical incision and remifentanil infusion, and remifentanil infusion significantly exaggerated and prolonged incision-induced pronociceptive effects. Glial fibrillary acidic protein, Iba1, proinflammatory cytokines (interleukin-1 beta and tumor necrosis factor-alpha), and phosphorylated mitogen-activated protein kinases (p-p38, p-JNK, and p-ERK1/2) were upregulated after surgical incision, remifentanil infusion, and especially after their combination. Intraoperative electroacupuncture significantly attenuated incision- and/or remifentanil-induced pronociceptive effects, spinal glial activation, proinflammatory cytokine upregulation, and phosphorylated mitogen-activated protein kinase upregulation.
   Conclusions: Our study suggests that remifentanil-induced postoperative hyperalgesia can be relieved by intraoperative electroacupuncture via inhibiting the activation of spinal glial cells, the upregulation of spinal proinflammatory cytokines, and the activation of spinal mitogen-activated protein kinases.
C1 [Shi, Changxi] Nanjing Univ Chinese Med, Nanjing Drum Tower Hosp, Clin Coll Tradit Chinese & Western Med, Nanjing, Jiangsu, Peoples R China.
   [Shi, Changxi] Nanjing Univ Chinese Med, Dept Anesthesiol, Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Jiangsu, Peoples R China.
   [Liu, Yue; Zhang, Wei; Lei, Yishan; Lu, Cui'e; Sun, Rao; Sun, Yu'e; Jiang, Ming; Gu, Xiaoping; Ma, Zhengliang] Nanjing Univ, Med Sch, Drum Tower Hosp, Dept Anesthesiol, Zhongshan Rd 321, Nanjing 210008, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University; Nanjing
   University of Chinese Medicine; Nanjing University
RP Ma, ZL (corresponding author), Nanjing Univ, Med Sch, Drum Tower Hosp, Dept Anesthesiol, Zhongshan Rd 321, Nanjing 210008, Jiangsu, Peoples R China.
EM mazhengliang1964@nju.edu.cn
RI Sun, Rao/JMC-2124-2023
OI Sun, Rao/0000-0002-0278-8087
FU National Natural Science Foundation of China [81471129, 81671087,
   81300950, 81300951, 81371207, 81171048, 81171047]; Department of Health
   of Jiangsu Province of China [XK201140, RC2011006]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Natural Science Foundation of China
   (81471129, 81671087, 81300950, 81300951, 81371207, 81171048, 81171047)
   and the Grant from the Department of Health of Jiangsu Province of China
   (XK201140, RC2011006).
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NR 53
TC 14
Z9 15
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD AUG 21
PY 2017
VL 13
AR 1744806917725636
DI 10.1177/1744806917725636
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FE4UG
UT WOS:000408208200001
PM 28825338
OA gold
DA 2026-01-16
ER

PT J
AU Li, YX
   Li, B
   Cui, Y
   Yang, XM
   Wang, SX
   Wang, XD
   Li, MY
   Tu, YF
   Jing, AN
   Zhou, YT
   Luo, M
AF Li, Yuxian
   Li, Bo
   Cui, Ying
   Yang, Xinming
   Wang, Sixuan
   Wang, Xiangdong
   Li, Mingyue
   Tu, Yufeng
   Jing, Anna
   Zhou, Yutong
   Luo, Mei
TI Acupuncture for chronic cancer pain: a systematic review and
   meta-analysis
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE Acupuncture; Chronic cancer pain; ICD-11; Meta-analysis; GRADE
   assessment
ID QUALITY-OF-LIFE; BREAST-CANCER; MANAGEMENT; WOMEN
AB Introduction Pain is highly prevalent among cancer patients. Cancer pain is classified as chronic cancer pain (MG30.10) and chronic post-cancer treatment pain (MG30.11) in the International Classification of Diseases, 11th Revision (ICD-11). This research aims to ascertain the efficacy and safety of acupuncture in treating chronic cancer pain (MG30.10). Methods Eight Chinese and English databases were systematically searched from their inception to December 31, 2024, to identify randomized controlled trials (RCTs) that examined the efficacy of acupuncture in combination with active treatments versus active treatment alone (identical to the treatment group), no treatment, or sham acupuncture for cancer pain management. The risk of bias was assessed using the version 2 of the Cochrane risk-of-bias tool (ROB 2.0), and data analysis was conducted utilizing RevMan 5.4 and Stata 17.0. Additionally, the quality of evidence was evaluated using the grading of recommendations assessment, development, and evaluation (GRADE) approach. Results A total of 21 RCTs were included in the meta-analysis, involving 1432 patients. The meta-analysis revealed that compared to the control group, the treatment group exhibited significantly reduced Numeric Rating Scales (NRS) scores (mean difference (MD) = -0.93, 95 % confidence interval (CI) [-1.21, -0.64], P<0.00001, low certainty), fewer burst pain events (MD = -2.13, 95 % CI [-2.86, -1.39], P < 0.00001, low certainty), reduced analgesic consumption (standard mean difference (SMD) =-0.60, 95 % CI [-0.84, -0.37], P<0.00001, moderate certainty), improved quality of life (MD =6.37, 95 % CI [3.21, 9.54], P<0.0001, low certainty), and diminished side effects of taking analgesics, with no serious adverse effects of acupuncture treatment. Conclusion The integration of acupuncture with analgesic drugs has demonstrated considerable potential to significantly mitigate pain and ameliorate adverse effects of analgesics in patients with chronic cancer pain (MG30.11). However, further high-quality RCTs are required to elucidate the efficacy of acupuncture in cancer pain management and optimize treatment protocols. Registration CRD42024550206
C1 [Li, Yuxian; Li, Bo; Cui, Ying; Yang, Xinming; Wang, Sixuan; Wang, Xiangdong; Li, Mingyue; Tu, Yufeng; Jing, Anna; Zhou, Yutong; Luo, Mei] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, 88 Changling Rd, Tianjin 300381, Peoples R China.
   [Li, Yuxian; Li, Bo; Cui, Ying; Yang, Xinming; Wang, Sixuan; Wang, Xiangdong; Li, Mingyue; Tu, Yufeng; Jing, Anna; Zhou, Yutong; Luo, Mei] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Acupuncture & Moxibust, 314 Anshan Xi Rd, Tianjin 300193, Peoples R China.
   [Li, Yuxian; Cui, Ying; Yang, Xinming; Wang, Sixuan; Wang, Xiangdong; Li, Mingyue; Tu, Yufeng; Jing, Anna; Zhou, Yutong; Luo, Mei] Tianjin Univ Tradit Chinese Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
   [Li, Bo] Qinghai Prov Hosp Tradit Chinese Med, 338 Qiyi Rd, Xining 810000, Qinghai, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Li, B (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Acupuncture & Moxibust, 314 Anshan Xi Rd, Tianjin 300072, Peoples R China.
EM ibou119@163.com
FU Open Project of National Clinical Research Center for Chinese Medicine
   Acupuncture [NCRCOP2023009]
FX We would like to express our sincere gratitude to the Open Project of
   National Clinical Research Center for Chinese Medicine Acupuncture and
   Moxibustion for their invaluable support (Grant No. NCRCOP2023009) .
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NR 55
TC 0
Z9 0
U1 7
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2025
VL 77
AR 102493
DI 10.1016/j.eujim.2025.102493
EA JUN 2025
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3RM8P
UT WOS:001507279200001
OA hybrid
DA 2026-01-16
ER

PT J
AU Yeh, ML
   Hsu, CC
   Lin, MT
   Lin, CJ
   Lin, JG
AF Yeh, Mei-Ling
   Hsu, Chin-Che
   Lin, Matthew
   Lin, Chuan-Ju
   Lin, Jaung-Geng
TI Effects of acupuncture-related intervention on chemotherapy-induced
   peripheral neuropathy and quality of life: An umbrella review
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Pain; Quality
   of life; Umbrella review
ID NONPHARMACOLOGICAL INTERVENTIONS
AB Background: Numerous studies have explored the role of acupuncture-related treatments in alleviating chemotherapy-induced peripheral neuropathy (CIPN) and improving the quality of life for patients with cancer, resulting in mixed findings. This umbrella review aimed to synthesize existing systematic reviews (SRs) to deliver an updated assessment of the certainty of evidence concerning the effects of acupuncture-related treatments on CIPN and quality of life among a diverse group of patients with cancer. Methods: This umbrella review considered eligible SRs published on one of nine electronic databases between inception and August 2024. It included adult patients with cancer of any stage who were undergoing chemotherapy. Interventions encompassed acupuncture, either alone or with electrical stimulation or moxibustion, and transcutaneous electrical acupoint/nerve stimulation (TEAS). The outcomes analyzed were changes in CIPN, nerve conduction velocity (NCV), and quality of life. Results: The outcomes were evaluated using data obtained from 14 SRs that demonstrated moderate to high methodological and reporting quality. The findings showed that acupuncture (either alone or combined with electrical stimulation) and TEAS effectively alleviated CIPN symptoms, reduced CIPN pain, improved NCV, and enhanced quality of life. Conclusion: The findings of this umbrella review indicate that these benefits were usually noticeable by the second week of treatment, persisted until the sixth week, and then gradually declined. Sensory nerve recovery occurred more rapidly than motor nerve recovery, often within 1.5 weeks. Although acupuncture combined with moxibustion or acupressure also enhanced patient outcomes, there was insufficient information available for further study analysis.
C1 [Yeh, Mei-Ling] Natl Taipei Univ Nursing & Hlth Sci, Taipei Med Univ Res Ctr Cochrane Taiwan, Sch Nursing, Minte Rd, Taipei 365, Taiwan.
   [Yeh, Mei-Ling] Taipei Med Univ Res Ctr Cochrane Taiwan, Taipei, Taiwan.
   [Hsu, Chin-Che] Kaohsiung Med Univ Hosp, 100 Tzyou 1st Rd, Kaohsiung, Taiwan.
   [Lin, Matthew] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, 365 Minte Rd, Taipei, Taiwan.
   [Lin, Chuan-Ju] Hsinchu Cathay Gen Hosp, 678,Sect 2,Zhonghua Rd, Hsinchu, Taiwan.
   [Lin, Chuan-Ju] Natl Taipei Univ Nursing & Hlth Sci, Taipei, Taiwan.
   [Lin, Jaung-Geng] China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung, Taiwan.
C3 National Taipei University of Nursing & Health Science (NTUNHS);
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   National Taipei University of Nursing & Health Science (NTUNHS); Cathay
   General Hospital; National Taipei University of Nursing & Health Science
   (NTUNHS); China Medical University Taiwan
RP Lin, CJ (corresponding author), Hsinchu Cathay Gen Hosp, 678,Sect 2,Zhonghua Rd, Hsinchu, Taiwan.; Lin, JG (corresponding author), China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung, Taiwan.
EM cgh306214@cgh.org.tw; jglin@mail.cmu.edu.tw
FU National Science of Technology Council [NSTC112-2314-B-227-007,
   NSTC113-2314-B-227-006]
FX The National Science of Technology Council funded this study under grant
   numbers NSTC112-2314-B-227-007 and NSTC113-2314-B-227-006.
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NR 53
TC 4
Z9 4
U1 3
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAY
PY 2025
VL 89
AR 103131
DI 10.1016/j.ctim.2025.103131
EA FEB 2025
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA X2O8B
UT WOS:001423815200001
PM 39900253
OA gold
DA 2026-01-16
ER

PT J
AU He, YH
   May, BH
   Zhang, AL
   Guo, XF
   Liu, YH
   Qu, YC
   Chang, XS
   Lu, CJ
   Xue, CC
   Zhang, HB
AF He, Yihan
   May, Brian H.
   Zhang, Anthony Lin
   Guo, Xinfeng
   Liu, Yihong
   Qu, Yanchun
   Chang, Xuesong
   Lu, Chuan-jian
   Xue, Charlie Changli
   Zhang, Haibo
TI Acupuncture for cancer pain: protocol for a pilot pragmatic randomised
   controlled trial
SO BMJ OPEN
LA English
DT Article
ID INHIBITOR-RELATED ARTHRALGIA; BREAST-CANCER; SAMPLE-SIZE; MANAGEMENT;
   REAL; VALIDATION; EXPECTANCY; ALLOCATION; SHAM; ELECTROACUPUNCTURE
AB Introduction Although acupuncture has been recommended for alleviating cancer pain by clinical guidelines, the level of the supporting evidence needs to be improved. A pragmatic randomised controlled trial (pRCT) in a hospital setting would provide real-world assessments of the overall clinical effects of acupuncture. This pilot trial aims to explore the feasibility and provide data for sample size calculations for a pRCT evaluating the effectiveness of acupuncture as an adjunctive therapy to routine medical care for cancer pain.
   Methods and analysis Thirty patients with cancer admitted to the oncology department with moderate or severe pain will be recruited. Participants will be randomised at a ratio of 1:1 to the adjunctive acupuncture group or a control group which receives routine pain management without acupuncture. The standardised section of the acupuncture protocol will be developed based on the results of reviews of the literature, recommendations in clinical guidelines and interviews with clinical experts. The acupuncturist will be allowed to tailor the protocol according to the individual situation of each participant. Primary outcomes relevant to the feasibility of conducting a fully powered trial include: numbers and proportions of participants recruited, screened, consented and randomised; numbers and reasons for withdrawals and dropouts; numbers and types of adverse events; feasibility of implementing the trial procedures; evaluation of the comprehensiveness and ease-of-use of the case report form. Secondary outcomes are clinical measurements of the effectiveness of the treatment that are intended for use in the full-scale trial. Analysis of feasibility will be descriptive and pain intensity measures will be analysed using mixed-effects regression.
   Ethics and dissemination Ethics approval was obtained from the Institutional Ethics Committee of Guangdong Provincial Hospital of Chinese Medicine (approval no: Z2017-184-01) and RMIT University Human Research Ethics Committee (reference no: 21361). Results will be disseminated in a peer-reviewed journal, and trial participants will be informed via email and/or phone calls.
C1 [He, Yihan; Guo, Xinfeng; Liu, Yihong; Qu, Yanchun; Lu, Chuan-jian; Xue, Charlie Changli; Zhang, Haibo] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [He, Yihan; May, Brian H.; Zhang, Anthony Lin; Guo, Xinfeng; Liu, Yihong; Qu, Yanchun; Lu, Chuan-jian; Xue, Charlie Changli; Zhang, Haibo] RMIT Univ, China Australia Int Res Ctr Chinese Med, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [He, Yihan; Guo, Xinfeng; Liu, Yihong; Qu, Yanchun; Chang, Xuesong; Lu, Chuan-jian; Xue, Charlie Changli; Zhang, Haibo] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Royal Melbourne Institute of
   Technology (RMIT); Guangzhou University of Chinese Medicine
RP Xue, CC; Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China.; Xue, CC; Zhang, HB (corresponding author), RMIT Univ, China Australia Int Res Ctr Chinese Med, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.; Xue, CC; Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China.
EM charlie.xue@rmit.edu.au; haibozh@aliyun.com
RI Zhang, Haibo/HLP-9266-2023; Xue, Charlie C/F-1244-2014; Zhang, Anthony
   Lin/AAR-6673-2021; Chang, Xuesong/HGB-8879-2022; Guo,
   Xinfeng/AAM-6850-2021
OI Xue, Charlie C/0000-0001-6937-9088; Zhang, Anthony
   Lin/0000-0002-0968-9380; Guo, Xinfeng/0000-0003-2699-9740
FU Guangdong Provincial Academy of Chinese Medical Sciences, China; RMIT
   University through the China-Australia International Research Centre for
   Chinese Medicine; School of Health and Biomedical Sciences, RMIT
   University; Specific Research Fund for TCM Science and Technology of
   Guangdong Provincial Hospital of Chinese Medicine (2018) [YN2018QL04];
   Research Project of Traditional Chinese Medicine Bureau of Guangdong
   Province (2019) [20191126]
FX This trial is supported by the Guangdong Provincial Academy of Chinese
   Medical Sciences, China, and RMIT University through the China-Australia
   International Research Centre for Chinese Medicine as well as PhD
   scholarship support to the first author provided by the School of Health
   and Biomedical Sciences, RMIT University, the 'Specific Research Fund
   for TCM Science and Technology of Guangdong Provincial Hospital of
   Chinese Medicine (2018)' (No: YN2018QL04), and the 'Research Project of
   Traditional Chinese Medicine Bureau of Guangdong Province (2019)' (No:
   20191126). HZ and CCX obtained funding for this study.
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NR 62
TC 7
Z9 9
U1 1
U2 19
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD AUG
PY 2019
VL 9
IS 7
AR e025564
DI 10.1136/bmjopen-2018-025564
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IW8US
UT WOS:000485269700318
PM 31289059
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Lian, WL
   Pan, MQ
   Zhou, DH
   Zhang, ZJ
AF Lian Wei-Ling
   Pan Min-qi
   Zhou Dai-han
   Zhang Zhang-jin
TI Effectiveness of Acupuncture for Palliative Care in Cancer Patients: A
   Systematic Review
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE acupuncture; palliative care; cancer; tumor
ID PROLONGED POSTOPERATIVE ILEUS
AB Objective: To critically evaluate the currently available randomized clinical trials regarding the effectiveness of acupuncture in palliative care for cancer patients, hence, to provide sufficient evidences for the widespread use of acupuncture in cancer treatment. Methods: Two independent reviewers extracted data from all of the randomized clinical trials (RCTs) that assessed the efficacy of acupuncture in palliative care for cancer patients. Seven databases were searched from their respective inception to December 2010. All eligible trials identified were evaluated by two independent reviewers using the Jadad scale, and data from the articles were validated and extracted. Results: In total, 33 RCTs met the inclusion criteria. The effects of acupuncture on different cancer-related aspects were shown, including chemotherapy or radiotherapy-induced side effects (13/33, 39.4%), cancer pain (6/33, 18.2%), post-operative urinary retention (4/33, 12.1%), quality of life (2/33, 6.1%), vasomotor syndrome (2/33, 6.1%), post-operative gastrointestinal dysfunction (2/33, 6.1%), prevention of prolonged postoperative ileus (2/33, 6.1%), joint symptoms (1/33, 3.0%), and immunomodulation (1/33, 3.0%). Conclusions: The result of our systematic review suggested that the effectiveness of acupuncture in palliative care for cancer patients is promising, especially in reducing chemotherapy or radiotherapy-induced side effects and cancer pain. Acupuncture may be an appropriate adjunctive treatment for palliative care.
C1 [Lian Wei-Ling; Pan Min-qi; Zhang Zhang-jin] Univ Hong Kong, Sch Chinese Med, LKS Fac Med, Hong Kong, Hong Kong, Peoples R China.
   [Lian Wei-Ling; Zhou Dai-han] Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510006, Guangdong, Peoples R China.
C3 University of Hong Kong; Guangzhou University of Chinese Medicine
RP Zhou, DH (corresponding author), Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510006, Guangdong, Peoples R China.
EM 13902206571@139.com
RI ZHANG, ZHANG-JIN/ORK-0709-2025
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NR 48
TC 39
Z9 47
U1 0
U2 36
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD FEB
PY 2014
VL 20
IS 2
BP 136
EP 147
DI 10.1007/s11655-013-1439-1
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AC9ND
UT WOS:000332860400009
PM 24338183
DA 2026-01-16
ER

PT J
AU Behzadmehr, R
   Dastyar, N
   Moghadam, MP
   Abavisani, M
   Moradi, M
AF Behzadmehr, Razieh
   Dastyar, Neda
   Moghadam, Mahdieh Poodineh
   Abavisani, Mahnaz
   Moradi, Mandana
TI Effect of complementary and alternative medicine interventions on cancer
   related pain among breast cancer patients: A systematic review
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Complementary and alternative medicine; Cancer related pain; Breast
   neoplasm; Systematic review
ID QUALITY-OF-LIFE; INHIBITOR-INDUCED ARTHRALGIA; LOW-BACK-PAIN;
   MINDFULNESS MEDITATION; MASSAGE THERAPY; MUSCULOSKELETAL SYMPTOMS;
   HYPNOSIS INTERVENTION; STRESS REDUCTION; CONTROLLED-TRIAL; ACUPUNCTURE
AB Objective: This systematic review aimed to evaluate the efficacy of CAM interventions for cancer-related pain in breast cancer patients.
   Methods: Databases (PubMed, Scopus, Web of Science, and EMBASE) were searched from January 1, 2000, up to April 31, 2019, using the keywords: Complementary and alternative medicine therapies and cancer related pain. Standard tools were used to evaluate the quality of the studies included.
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   Conclusions: Despite the positive effect of various CAM interventions in reducing cancer-related pain, necessary precautions should be adopted to use them alongside other treatments to control cancer pain in the clinical setting.
C1 [Behzadmehr, Razieh] Zabol Univ Med Sci, Sch Med, Dept Radiol, Zabol, Iran.
   [Dastyar, Neda] Jiroft Univ Med Sci, Dept Midwifery, Jiroft, Iran.
   [Moghadam, Mahdieh Poodineh] Zabol Univ Med Sci, Fac Nursing & Midwifery, Dept Nursing, Zabol, Iran.
   [Abavisani, Mahnaz] Neyshabur Univ Med Sci, Dept Nursing, Med Surg Nursing, Neyshabur, Iran.
   [Moradi, Mandana] Zabol Univ Med Sci, Sch Pharm, Clin Pharm Dept, Zabol, Iran.
RP Moradi, M (corresponding author), Zabol Univ Med Sci, Behdasht St, Zabol, Iran.
EM mmandana310@gmail.com
RI Poodineh moghadam, Mahdieh/G-1994-2017; Moradi, Mandana/AAD-2102-2021;
   behzadmehr, razieh/S-7029-2016; dastyar, neda/E-1401-2018
OI Poodineh moghadam, Mahdieh/0000-0002-6245-7749; behzadmehr,
   razieh/0000-0002-8465-2940; dastyar, neda/0000-0003-0590-7405
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NR 102
TC 34
Z9 46
U1 1
U2 68
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAR
PY 2020
VL 49
AR 102318
DI 10.1016/j.ctim.2020.102318
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA LG1NY
UT WOS:000527877700053
PM 32147038
DA 2026-01-16
ER

PT J
AU Han, CH
   Liu, YJ
   Fan, HF
   Li, DH
   Guo, N
AF Han, Changhui
   Liu, Yingjuan
   Fan, Huanfang
   Li, Dehui
   Guo, Na
TI Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer
   Therapy-A Meta-Analysis and Systematic Review
SO CLINICAL EPIDEMIOLOGY
LA English
DT Review
DE acupuncture; opioid-induced constipation; cancer; pain; meta-analysis
ID PATIENT ASSESSMENT; MANAGEMENT; PAIN; RELIABILITY; VALIDITY
AB Cancer pain is a common problem in clinical cancer therapy. Opioid analgesia is one of the most effective drugs for pain relief with satisfying performance besides the side effect of opioid-induced constipation (OIC). Acupuncture, as a Chinese traditional noninvasive intervention, has been applied to clinical cancer pain management and functional constipation therapy. However, only a few studies have adopted this treatment for OIC patients. Due to limited numbers of investigated subjects and variability of application methods, including treatment apparatus, acupoints, durations, and sessions, the interpretation of acupuncture's therapy effects from single-site randomized clinical trials (RCT) is limited. Therefore, we conducted a meta-analysis by collecting published data from Pubmed, Embase, Cochrane library, and Web of Science. Five RCTs focusing on the application of acupuncture with or without medication in OIC patients were included. An overall remission rate of 86.8% in the acupuncture-treated group was achieved, higher than the control group (78.9%; RR, 1.10, 95% CI [1.03, 1.18]). The symptom scores, reporting on defecation frequency, defecation straining, abdominal pain, defection time, and stool property, in acupuncture groups were lower than control groups with a standardized mean difference (SMD) of -2.21 [-4.15, -0.27]. The quality of life (QOL) for patients in the acupuncture treated group increased compared to the control group with reduced PAC-QOL scores (SMD, -1.02 [-1.78, -0.26]). Referring to the effects from pure acupuncture treatment (SMD, -0.43 [-0.83, -0.03]), the co-intervention of acupuncture and drugs (SMD, -1.77 [-2.51, -1.02]) improved the life quality of patients more remarkably (P < 0.05). Overall, our data confirmed the therapeutic effects of acupuncture in the treatment of OIC. The co-intervention of acupuncture with drugs improves the outcomes of OIC patients better than a single strategy. Combined therapy with both medicine and acupuncture has insightful potential for future clinical cancer patient management on constipation problems.
C1 [Han, Changhui; Fan, Huanfang; Li, Dehui; Guo, Na] Hebei Univ Tradit Chinese Med, Affiliated Hosp, Prov Hosp Tradit Chinese Med, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yingjuan] Univ Manchester, Inst Cardiovasc Sci, Manchester, Lancs, England.
C3 University of Manchester
RP Liu, YJ (corresponding author), Univ Manchester, 46 Grafton St, Manchester M13 9PT, Lancs, England.
EM liuyingjuan2008@gmail.com
RI Li, Dehui/IRZ-6284-2023
OI Liu, Yingjuan/0000-0003-3028-3526
FU Scientific Research Project of Hebei Administration of Traditional
   Chinese Medicine [2019030]
FX This work was supported by the Scientific Research Project of Hebei
   Administration of Traditional Chinese Medicine (Grants No. 2019030). The
   funding body played no role in the design of the study and collection,
   analysis, and interpretation of data and in writing the manuscript.
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NR 40
TC 12
Z9 14
U1 3
U2 28
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1349
J9 CLIN EPIDEMIOL
JI Clin. Epidemiol.
PY 2021
VL 13
BP 907
EP 919
DI 10.2147/CLEP.S324193
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA WE0ZY
UT WOS:000705359100002
PM 34629905
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, CT
   Hsieh, TM
   Shih, FY
   Lai, WH
   Hsieh, CH
   Wu, BY
   Chen, YH
AF Liu, Chun-Ting
   Hsieh, Ting-Min
   Shih, Fu-Yuan
   Lai, Wei-Hung
   Hsieh, Ching-Hua
   Wu, Bei-Yu
   Chen, Yung-Hsiang
TI The effects of electroacupuncture and laser acupuncture therapy for
   patients with major trauma A study protocol
SO MEDICINE
LA English
DT Article
DE acupuncture; cholinergic anti-inflammatory pathway; inflammation; laser
   acupuncture; major trauma
ID VAGUS NERVE-STIMULATION; SEVERITY; INJURIES
AB Background: Major trauma is the leading cause of death in the young population. The inflammatory and anti-inflammatory responses are associated with posttraumatic morbidity and mortality; however, it is not fully clear how to reestablish the homeostasis in patients with major trauma. Methods: This study will be a prospective, randomized, placebo-controlled, partially double-blinded, three-armed trial. One hundred eighty participants diagnosed with major trauma will be randomly assigned to an electroacupuncture (EA), a laser acupuncture (LA), or a sham laser acupuncture group in a 1:1:1 ratio. All participants will undergo EA, LA, or sham laser acupuncture intervention once a day on 5 acupoints (LI4, PC6, ST36, SP6, and EX-HN1) for 14 consecutive days after enrollment. The primary outcome measure will be the length of hospital stay. Secondary outcomes will be inflammatory mediators, including serum C-reactive protein, interleukin (IL)-6, tumor necrosis factor-alpha, IL-1 beta, and IL-10. Clinical outcomes will be numeric rating scale scores for pain, sequential organ failure assessment, ICU length of stay, 30-day mortality, and WHO Disability Assessment Schedule. Data will be analyzed by chi-square test or t test for pairwise comparisons, as well as one-way ANOVA followed by post hoc Tukey method between groups. Objectives: The aim of this protocol is to investigate the clinical effects of EA and LA on major trauma.
C1 [Liu, Chun-Ting; Wu, Bei-Yu] Kaohsiung Chang Gung Mem Hosp, Dept Chinese Med, Kaohsiung, Taiwan.
   [Liu, Chun-Ting; Hsieh, Ting-Min; Shih, Fu-Yuan; Lai, Wei-Hung; Hsieh, Ching-Hua; Wu, Bei-Yu] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Liu, Chun-Ting; Wu, Bei-Yu; Chen, Yung-Hsiang] China Med Univ, Grad Inst Integrated Med, Coll Chinese Med, Res Ctr Chinese Med & Acupuncture, Taichung, Taiwan.
   [Liu, Chun-Ting] Jen Ai Hosp, Dept Chinese Med, Dali Branch, Taichung, Taiwan.
   [Hsieh, Ting-Min; Lai, Wei-Hung] Kaohsiung Chang Gung Mem Hosp, Div Trauma Surg, Kaohsiung, Taiwan.
   [Shih, Fu-Yuan] Kaohsiung Chang Gung Mem Hosp, Dept Neurosurg, Kaohsiung, Taiwan.
   [Hsieh, Ching-Hua] Kaohsiung Chang Gung Mem Hosp, Dept Surg, Div Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Wu, Bei-Yu] Fooyin Univ Coll Nursing, Kaohsiung, Taiwan.
   [Chen, Yung-Hsiang] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; China Medical
   University Taiwan; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Asia University Taiwan
RP Chen, YH (corresponding author), China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung, Taiwan.
EM yhchen@mail.cmu.edu.tw
RI Liu, Chun-Ting/GWM-4693-2022; Chen, Yung-Hsiang/K-6766-2015
OI Chen, Yung-Hsiang/0000-0002-8756-5113
FU Ministry of Science and Technology, Taiwan [MOST
   110-2320-B-182A-008-MY3]
FX This work is financially supported by the Ministry of Science and
   Technology, Taiwan under grant number MOST 110-2320-B-182A-008-MY3. The
   funder will have no role in the trial design, manuscript writing, or
   decision making for publication. Ministry of Science and Technology:
   Tel: +886-2-2737-7992. Address: 106, Sec. 2, Heping E. Rd., Taipei
   10622, Taiwan, ROC.
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NR 25
TC 1
Z9 2
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 30
PY 2021
VL 100
IS 52
AR e28367
DI 10.1097/MD.0000000000028367
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XX2RO
UT WOS:000736149900044
PM 34967368
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU He, YH
   Zhang, HB
   Li, YF
   Long, SQ
   Xiao, SJ
   May, BH
   Zhang, AL
   Guo, XF
   Xue, CC
   Lu, CJ
AF He, Yihan
   Zhang, Haibo
   Li, Yifang
   Long, Shunqin
   Xiao, Shujing
   May, Brian H.
   Lin Zhang, Anthony
   Guo, Xinfeng
   Xue, Charlie Changli
   Lu, Chuanjian
TI Acupuncture combined with opioids for cancer pain: a pilot pragmatic
   randomized controlled trial
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE acupuncture; cancer pain; pharmacological analgesics; pragmatic trial
ID INDUCED NAUSEA; BREAST-CANCER
AB Objective: Given the existing evidence for the analgesic effect of acupuncture, the current study aimed to assess whether acupuncture could be feasible and manageable as an adjunctive therapy for cancer pain in a real-world hospital setting. Methods: Thirty patients in an Oncology department with moderate or severe pain were recruited and randomized to an adjunctive acupuncture group or control group, who received pharmacotherapy for pain management without acupuncture. The duration of the treatment course was 1 week with a 2-week follow-up. In total, four acupuncture sessions were administered, on days 1/2/4/6 of the trial. Pain intensity was measured using a numerical rating scale (NRS) and the daily opioid dose was recorded. Results: The overall trends favored acupuncture for both pain intensity and daily opioid consumption. The proportion of participants experiencing at least a 2-point reduction in the NRS at the end of the treatment was 93% (n = 14/15) for the acupuncture group and 57% (n = 8/14) for the control group (risk difference (RD) 36.1%, 95% confidence interval (CI) [7.4%-65.0%]; relative risk (RR) 1.63, 95% CI [1.02-2.62]; p = 0.04). There were no serious adverse events and no dropouts during the treatment. Conclusion: This pilot study showed that adding acupuncture to routine analgesia for patients with cancer pain was feasible and acceptable to patients. The clinical effects of adding acupuncture as an adjunctive therapy need to be further evaluated.
C1 [He, Yihan; Guo, Xinfeng; Xue, Charlie Changli; Lu, Chuanjian] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, China Australia Int Res Ctr Chinese Med,Guangdong, 111 Dade Rd, Guangzhou 510120, Peoples R China.
   [He, Yihan; May, Brian H.; Lin Zhang, Anthony; Xue, Charlie Changli; Lu, Chuanjian] RMIT Univ, Sch Hlth & Biomed Sci, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.
   [Zhang, Haibo; Long, Shunqin; Xiao, Shujing] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Dept Oncol,Guangdong Prov Hosp Chinese Med, Guangzhou, Peoples R China.
   [Li, Yifang] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med,Dept Tradit Thera, Guangzhou, Peoples R China.
   [Lu, Chuanjian] Tradit Chinese Med Syndrome, Guangdong Prov Key Lab Clin Res, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Royal Melbourne Institute of
   Technology (RMIT); Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine
RP Xue, CC; Lu, CJ (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, China Australia Int Res Ctr Chinese Med,Guangdong, 111 Dade Rd, Guangzhou 510120, Peoples R China.
EM charlie.xue@rmit.edu.au; luchuanjian888@vip.sina.com
RI Guo, Xinfeng/AAM-6850-2021; Xue, Charlie C/F-1244-2014; Zhang,
   Anthony/AAR-6673-2021; Li, Yifang/HTO-9769-2023; Zhang,
   Haibo/HLP-9266-2023
OI Guo, Xinfeng/0000-0003-2699-9740; He, Yihan/0000-0002-4833-0231; Xue,
   Charlie C/0000-0001-6937-9088; 
FU Specific Research Fund for TCM Science and Technology of Guangdong
   Provincial Hospital of Chinese Medicine (2018) [YN2018QL04]; Research
   Project of Traditional Chinese Medicine Bureau of Guangdong Province
   (2019) [20191126]; Guangdong Provincial Academy of Chinese Medical
   Sciences, China; RMIT University through the China-Australia
   International Research Center for Chinese Medicine
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: The authors are
   grateful for the support of the Specific Research Fund for TCM Science
   and Technology of Guangdong Provincial Hospital of Chinese Medicine
   (2018; YN2018QL04); the Research Project of Traditional Chinese Medicine
   Bureau of Guangdong Province (2019; 20191126); the Guangdong Provincial
   Academy of Chinese Medical Sciences, China; and RMIT University through
   the China-Australia International Research Center for Chinese Medicine.
CR Bao T, 2018, ACUPUNCT MED, V36, P80, DOI 10.1136/acupmed-2017-011435
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NR 28
TC 8
Z9 10
U1 7
U2 41
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2022
VL 40
IS 2
BP 133
EP 141
AR 09645284211056016
DI 10.1177/09645284211056016
EA NOV 2021
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ZJ1IF
UT WOS:000717645600001
PM 34755569
DA 2026-01-16
ER

PT J
AU Gatti, A
   Gentili, M
   Iorno, V
   Mammucari, M
   Tufaro, G
   Lazzari, M
   Sabato, AF
AF Gatti, Antonio
   Gentili, Marta
   Iorno, Vittorio
   Mammucari, Massimo
   Tufaro, Giuseppe
   Lazzari, Marzia
   Sabato, Alessandro Fabrizio
TI Beyond the Traditional Definition of Breakthrough Pain: An Observational
   Study
SO ADVANCES IN THERAPY
LA English
DT Article
DE Breakthrough pain; Chronic pain; Gender; Non-oncological pain;
   Observational study; Oncological pain; Pain severity
ID CANCER-PAIN; PREVALENCE
AB Breakthrough pain (BTP) is traditionally defined as a transitory pain flare in opioid-treated patients with chronic background pain. This definition has, however, been challenged in recent years. This study aimed to analyze BTP prevalence in different pain conditions.
   This was a prospective, noninterventional, observational study conducted from June to September 2011 in two Italian pain treatment reference centres. Consecutive patients aged > 18 years with oncological or non-oncological pain were eligible for this study; background pain was acute/ subacute (< 3 months) or chronic (> 3 months). The characteristics of pain were evaluated by means of a structured interview by physicians, and patients were asked to complete a dedicated clinical study form.
   The following outcomes were assessed: chronic pain duration (in patients with chronic pain), BTP prevalence, and number and severity of daily BTP episodes. All outcomes were assessed in four populations of patients with: (a) chronic oncological pain; (b) chronic non-oncological pain; (c) non-chronic oncological pain; (d) nonchronic non-oncological pain. The correlation between BTP and gender was also investigated.
   Of 1,270 patients with chronic pain, 1,086 had non-oncological pain (85.5%). Most patients (68.6%) with non-oncological pain were female (P = 0.001). Pain duration was significantly longer in non-oncological pain versus oncological pain groups (P = 0.002). BTP prevalence was lower in non-oncological patients (P < 0.001). No differences were reported in terms of number and severity of daily BTP episodes. BTP was more frequent in females with non-oncological pain (P = 0.04). Females had a significantly higher pain severity (P = 0.02) than males.
   BTP is frequently reported in patients who do not have BTP according to the traditional definition. BTP frequency and severity is similar in oncological and non-oncological pain.
C1 [Gatti, Antonio; Tufaro, Giuseppe; Lazzari, Marzia; Sabato, Alessandro Fabrizio] Univ Roma Tor Vergata, Tor Vergata Polyclin, Emergency Care Crit Care Med Pain Med & Anesthesi, Rome, Italy.
   [Gentili, Marta] Patient Assoc Vivere Senza Dolore, I-20154 Milan, Italy.
   [Iorno, Vittorio] Osped Maggiore Policlin Ca Granda, Fdn IRCCS, Milan, Italy.
   [Mammucari, Massimo] Primary Care ASL RM F, Rome, Italy.
C3 University of Rome Tor Vergata; IRCCS Ca Granda Ospedale Maggiore
   Policlinico
RP Gentili, M (corresponding author), Patient Assoc Vivere Senza Dolore, Piazza EL Morselli 1, I-20154 Milan, Italy.
EM presidenza@viveresenzadolore.it
RI mammucari, massimo/AAB-9899-2020
OI mammucari, massimo/0000-0002-9515-3549
CR [Anonymous], COCHRANE DATABASE SY
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NR 19
TC 9
Z9 14
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0741-238X
J9 ADV THER
JI Adv. Ther.
PD MAR
PY 2013
VL 30
IS 3
BP 298
EP 305
DI 10.1007/s12325-013-0013-8
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 109PM
UT WOS:000316380500007
PM 23444055
DA 2026-01-16
ER

PT J
AU Shi, GX
   Tu, JF
   Wang, TQ
   Yang, JW
   Wang, LQ
   Lin, LL
   Wang, Y
   Li, YT
   Liu, CZ
AF Shi, Guang-Xia
   Tu, Jian-Feng
   Wang, Tian-Qi
   Yang, Jing-Wen
   Wang, Li-Qiong
   Lin, Lu-Lu
   Wang, Yu
   Li, Yong-Ting
   Liu, Cun-Zhi
TI Effect of Electro-Acupuncture (EA) and Manual Acupuncture (MA) on
   Markers of Inflammation in Knee Osteoarthritis
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE knee osteoarthritis; electro-acupuncture; manual acupuncture;
   inflammation
ID PAIN; EXPRESSION; CARTILAGE; CHONDROCYTES; MODULATION; OUTCOMES
AB Background: Inflammation plays a significant role in the pathogenesis of knee osteoarthritis (KOA). Although both electro-acupuncture (EA) and manual acupuncture (MA) are known to influence systemic inflammation, little is known about the potential changes in inflammation as a working mechanism of EA and MA in KOA.
   Methods: Data from the Acupuncture for Knee Osteoarthritis Trial (ATKOA) were used. Serum concentrations of inflammatory factors (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6, IL-8, IL-18, IL-4, IL-10, IL-13, IL-15, IL-17, monocyte chemotactic protein-1 (MCP-1), CC-chemokine ligand 5 (CCL5), and cartilage degradation biomarkers (matrix metalloproteinase-1 MMP-1, MMP-3, MMP-13 and cartilage oligomeric matrix protein COMP)) were measured at baseline and after 8 weeks of treatment. Clinical outcomes were valid and reliable self-reported pain and function measures for osteoarthritis using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) at baseline and post-treatment.
   Results: Both 8-weeks EA and MA significantly reduced pro-inflammatory cytokines (TNF alpha, IL-1 beta), and cartilage degradation biomarkers (MMP-3, MMP-13) significantly increased the anti-inflammatory cytokine IL-13 compared with pre-treatment (p<0.05). Further, the reduction of TNF-alpha was more significant in EA when compared to MA (p=0.046). While there was no significant difference between groups in cytokines IL-1 beta (p=0.102), MMP-3 (p=0.113), MMP-13 (p=0.623) or IL-13 (p=0.935). Moreover, in both EA and MA, the effect of acupuncture on the VAS and WOMAC function scale after 8 weeks is clinically important, although no significant differences were found between groups.
   Conclusion: Eight weeks of both EA and MA seem to provide improvement in pain relief and function among individuals with mild to moderate knee OA. This benefit is partly mediated by changes of major inflammatory factors TNF-alpha, IL-1 beta and IL-13.
C1 [Shi, Guang-Xia; Wang, Yu; Li, Yong-Ting] Capital Med Univ, Dept Acupuncture & Moxibust, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.
   [Tu, Jian-Feng; Wang, Tian-Qi; Yang, Jing-Wen; Wang, Li-Qiong; Lin, Lu-Lu; Liu, Cun-Zhi] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
C3 Capital Medical University; Beijing University of Chinese Medicine
RP Liu, CZ (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
EM lcz_tg@126.com
RI Lin, Lulu/JSL-6136-2023; Li, Yongting/LKJ-7509-2024; Tu,
   Jian-Feng/J-7768-2017; Liu, Cunzhi/J-9190-2017; WANG,
   TIANQI/HOA-5441-2023
OI Tu, Jian-Feng/0000-0003-2887-3383; 
FU The 4th Project of China Association of Science and Technology Youth
   Talents Enrollment Project [2018QNRC001]
FX This study was supported by The 4th Project of China Association of
   Science and Technology Youth Talents Enrollment Project (2018QNRC001).
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NR 30
TC 58
Z9 72
U1 2
U2 36
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2020
VL 13
BP 2171
EP 2179
DI 10.2147/JPR.S256950
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA NF1DC
UT WOS:000563041200001
PM 32904642
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yin, Y
   Wang, LA
   Zhao, L
   Lin, L
   Shen, XY
AF Yin, Yue
   Wang, Lina
   Zhao, Ling
   Lin, Lin
   Shen, Xueyong
TI Effect of 10.6 μm laser moxibustion on inflammation in diabetic
   peripheral neuropathy rats
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes mellitus; diabetic peripheral neuropathy; laser moxibustion;
   inflammation; NF- kappa B
ID NF-KAPPA-B; ACUPUNCTURE
AB Diabetic peripheral neuropathy (DPN) is the main cause of disability in diabetes patients but the efficacy of available drugs is poor. Moxibustion is an adjunctive treatment for DPN that can reduce symptoms. The peak value of the far infrared wavelength of 10.6 & mu;m laser moxibustion is close to the infrared radiation spectrum of traditional moxibustion. Its effect is similar to that of moxibustion and does not cause pain, infection or produce irritating smoke. Twenty-four male SD rats were divided into control (Con), DPN, laser moxibustion (LM), and pyrrolidine dithiocarbamate (PDTC) groups (n=6/group). The DPN, LM and PDTC group rats were intraperitoneally injected with 1% streptozotocin (STZ) to induce a model of DPN. LM group rats were irradiated with a laser at bilateral ST36 acupoints for 15 min, once every other day, for 14 days. PDTC group rats were intraperitoneally injected with PDTC once a day. Body weight, blood glucose, and paw withdrawal mechanical threshold (PWMT) were measured and laser speckle imaging (LSI) performed before and after modeling and at 1 and 2 weeks after intervention. Two weeks after intervention, changes in serum interleukin 1 & beta; (IL1 & beta;), interleukin 6 (IL6), tumor necrosis factor & alpha; (TNF & alpha;) and nerve growth factor (NGF) were analyzed, and the abundance of NF-& kappa;B and I & kappa;B-& alpha; proteins and levels of NF-& kappa;B and I & kappa;B-& alpha; mRNAs in the sciatic nerve were observed. The results showed that 10.6 & mu;m laser moxibustion can relieve pain, improve microcirculation, and alleviate inflammation in DPN rats, possibly via the NF-& kappa;B inflammatory pathway.
C1 [Yin, Yue; Wang, Lina; Zhao, Ling; Shen, Xueyong] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai, Peoples R China.
   [Lin, Lin] Shanghai Univ Tradit Chinese Med, Sch Nursing, Shanghai, Peoples R China.
   [Shen, Xueyong] Shanghai Res Ctr Acupuncture & Meridian, Lab Syst Physiol Acupuncture & Meridian, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Shen, XY (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai, Peoples R China.; Lin, L (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Nursing, Shanghai, Peoples R China.; Shen, XY (corresponding author), Shanghai Res Ctr Acupuncture & Meridian, Lab Syst Physiol Acupuncture & Meridian, Shanghai, Peoples R China.
EM linlin5200@shutcm.edu.cn; sxy1@shutcm.edu.cn
RI ZHAO, LING/OIR-6110-2025
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NR 48
TC 5
Z9 6
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 1
PY 2023
VL 14
AR 1203677
DI 10.3389/fendo.2023.1203677
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA P1CI5
UT WOS:001048082300001
PM 37593350
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Brozovic, G
   Lesar, N
   Janev, D
   Bosnjak, T
   Muhaxhiri, B
AF Brozovic, Gordana
   Lesar, Nikola
   Janev, Dimitar
   Bosnjak, Tomislav
   Muhaxhiri, Burim
TI CANCER PAIN AND THERAPY
SO ACTA CLINICA CROATICA
LA English
DT Article; Proceedings Paper
CT 8th Croatian Congress on Regional Anaesthesia and Analgesia with
   International Participation
CY SEP 02-03, 2022
CL Catholic Univ Croatia, Sch Med, Zagreb, CROATIA
SP Croatian Med Assoc, Croatian Soc Reg Anaesthesia & Analgesia, European Soc Reg Anaesthesia & Pain Therapy, Croatian Acad Sci & Arts, Dept Med Sci
HO Catholic Univ Croatia, Sch Med
DE cancer pain; opioids; non-opioids; adjuvant drugs; regional nerve block;
   integrative medicine
ID MANAGEMENT; UPDATE
AB Cancer pain is not a homogenous and clearly understood pathological process. The best treatment is a combination of drug and non-drug measures. Pain is divided into visceral, bone or neuropathic pain and has characteristics of continuous or intermittent pain. Cancer bone pain therapy remains centered on strong opioid, radiotherapy and bisphosphonates. Invasive procedures are aimed to improve neurological function, ambulation and pain relief. Solid tumors often demand surgery. Treatment of acute postoperative pain is crucial for the prevention of chronic pain. Chemotherapy and radiation sometimes also cause pain. The management of cancer pain has improved because of rapid diagnosis and treatment, understanding of analgesics and the cooperation of patients and their family. The presence of special pain centers in hospitals also raise standard of cancer pain management. Drug therapy with non-opioid, opioid and adjuvant drugs is the base of such management. The side effects must be monitored and timely treated. Methods of regional nerve blockade in pain control are numerous. Placement of epidural, intrathecal and subcutaneous catheters, conductive nerve blocks with continuous delivery of mixed local anesthetics are very successful for selected patients. Conventional physical therapy involving lymphatic drainage is useful. Acupuncture, psychotherapy and similar methods are also applicable.
C1 [Brozovic, Gordana; Lesar, Nikola; Janev, Dimitar; Bosnjak, Tomislav; Muhaxhiri, Burim] Univ Hosp Tumors, Sestre Milosrdnice Univ Hosp Ctr, Div Anaesthesiol Reanimatol & Intens Care Med, Zagreb, Croatia.
   [Brozovic, Gordana] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek, Croatia.
C3 University of Zagreb; University of JJ Strossmayer Osijek
RP Brozovic, G (corresponding author), Sestre Milosrdnice Univ Hosp Ctr, Div Anaesthesiol Reanimatol & Intens Care Med, Ilica 197, Zagreb, Croatia.
EM brozovic.gordana@gmail.com
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NR 25
TC 18
Z9 25
U1 0
U2 14
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PY 2022
VL 61
SU 2
BP 103
EP 108
DI 10.20471/acc.2022.61.s2.13
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 7I6WQ
UT WOS:000904026200014
PM 36824638
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Dai, L
   Liu, Y
   Ji, G
   Xu, YX
AF Dai, Liang
   Liu, Yang
   Ji, Guang
   Xu, Yangxian
TI Acupuncture and Derived Therapies for Pain in Palliative Cancer
   Management: Systematic Review and Meta-Analysis Based on Single-Arm and
   Controlled Trials
SO JOURNAL OF PALLIATIVE MEDICINE
LA English
DT Review
DE acupuncture; cancer pain; systematic review
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; CLINICAL-TRIALS;
   SYMPTOMS; CARE; ELECTROSTIMULATION; PLACEBOS; OUTCOMES
AB Background: Acupuncture is a classical complementary therapy, but benefits in palliative cancer pain are still unclear due to lack of consistent evidence.
   Objectives: To comprehensively evaluate the effectiveness of acupuncture and derived therapies (such as electroacupuncture, laser acupuncture, and transcutaneous electrical nerve stimulation) for analgesia in palliative cancer care based on both single-arm and controlled trials.
   Design: Eight databases were searched from inception to August 31, 2020. Both single-arm trials and controlled trials were included. The primary outcome was the change in pain intensity, as evaluated by the numeric rating scale (NRS) and the visual analog scale.
   Subjects: Adults with cancer.
   Results: Forty-one controlled studies with 2685 participants and 18 single-arm studies with 1084 participants were included. For controlled trials, meta-analysis indicated that acupuncture and derived therapies in addition led to greater reductions in the NRS score than conventional analgesics alone (weighted mean difference [WMD]: 1.33 [0.85-1.82], p < 0.001). For single-arm trials, meta-analysis showed that both the immediate effect (WMD: 1.57 [1.43-1.71], p < 0.001) and long-term longitudinal effect (WMD: 1.81 [1.25-2.37], p < 0.001) of acupuncture on analgesia were positive, as evaluated by the NRS, respectively. The benefits of acupuncture and derived therapies were also seen in quality of life and the global improvement rate. LI4 (Hegu) was the most frequently used acupoint.
   Conclusions: This systematic review supported the application of acupuncture and derived therapies for managing pain during palliative cancer care from two dimensions. Further studies could explore the effect of acupuncture on other predominant symptoms in palliative cancer patients.
C1 [Dai, Liang; Ji, Guang] Shanghai Univ Tradit Chinese Med, Inst Digest Dis, Longhua Hosp, Shanghai, Peoples R China.
   [Liu, Yang; Xu, Yangxian] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Gastrointestinal Surg, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Xu, YX (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Gastrointestinal Surg, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM xuyangxian@163.com
FU Shanghai Three-year Action Plan for Accelerating the Development of
   Traditional Chinese Medicine [ZY(2018-2020)-CCCX-2002-01]
FX This work was supported by the Shanghai Three-year Action Plan for
   Accelerating the Development of Traditional Chinese Medicine
   (ZY(2018-2020)-CCCX-2002-01). The funding body had no role in the study
   design, data handling, publication decision, or article drafting.
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NR 90
TC 8
Z9 9
U1 1
U2 49
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-6218
EI 1557-7740
J9 J PALLIAT MED
JI J. Palliat. Med.
PD JUL 1
PY 2021
VL 24
IS 7
BP 1078
EP 1099
DI 10.1089/jpm.2020.0405
EA MAR 2021
PG 22
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA SS2QO
UT WOS:000628685000001
PM 33691493
DA 2026-01-16
ER

PT J
AU Xu, LP
   Yang, SL
   Su, SQ
   Huang, BX
   Lan, XM
   Yao, RJ
AF Xu, Li-Ping
   Yang, Shi-Lai
   Su, Shao-Qing
   Huang, Bi-Xia
   Lan, Xin-Mei
   Yao, Ru-Jie
TI Effect of wrist-ankle acupuncture therapy combined with auricular
   acupuncture on cancer pain: A four-parallel arm randomized controlled
   trial
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Wrist-ankle acupuncture therapy; Auricular acupuncture; Combine therapy;
   Cancer pain
AB Background: Cancer pain affects the quality of life of cancer patients; therefore, various methods exist for alleviating the adverse effects caused by cancer pain. Nonpharmacological intervention is regarded as an important means of auxiliary therapy for drug treatment, with acupuncture receiving the most attention; However, there are numerous types of acupuncture therapies, including acupuncture, wrist-ankle acupuncture (WAA) and auricular acupuncture (AA). Previous studies have demonstrated that all types of acupuncture therapy can alleviate cancer pain. However, the effects and pathways of different acupuncture treatments are not similar, and it is unknown whether single therapy or combination therapy has better analgesic effects. This study aimed to examine the effect of WAA therapy combined with AA on cancer pain.
   Design: A randomized controlled trial.
   Method: A total of 160 patients were selected and randomly divided into groups A, B, C and D, with 40 patients in each group. Group A received conventional analgesia alone, with opioids administered based on the World Health Organization (WHO) 3-tiered "cancer pain ladder". Group B received WAA, in addition to the treatment received by group A. Group C received AA, in addition to the treatment received by group A. Group D received WAA combined with AA, in addition to the treatment received by group A. Analgesic effects and analgesic drug use before and 3, 5 and 7 days after treatment were observed in each group.
   Result: A total of 159 patients were included in the analysis. The verbal rating scale (VRS) and numeric rating scale (NRS) scores for patients who received mono-acupuncture therapy and combination therapy for 1 week were significantly different from those of the control group. Combination therapy had a stronger effect on the VRS score and a faster onset time, based on the NRS score, and the patients who received combination therapy had reduced analgesic drug use.
   Conclusion: WAA combined with AA can more quickly reduce pain symptoms with more lasting analgesic effects and can effectively reduce analgesic drug use.
C1 [Xu, Li-Ping] Fujian Univ Tradit Chinese Med, Nursing Dept, Affiliated Peoples Hosp 3, Fuzhou, Peoples R China.
   [Yang, Shi-Lai] Quanzhou Med Coll, Sch Nursing, Quanzhou, Peoples R China.
   [Su, Shao-Qing] Fujian Univ Tradit Chinese Med, Peoples Hosp, Fuzhou, Peoples R China.
   [Huang, Bi-Xia; Lan, Xin-Mei; Yao, Ru-Jie] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp 3, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine
RP Xu, LP (corresponding author), Fujian Univ Tradit Chinese Med, Nursing Dept, Affiliated Peoples Hosp 3, Fuzhou, Peoples R China.; Yang, SL (corresponding author), Quanzhou Med Coll, Sch Nursing, Quanzhou, Peoples R China.
EM 785514523@qq.com; 247872083@qq.com
RI yang, shilai/ACO-9304-2022
OI yang, shilai/0009-0008-2365-8274
FU Fujian University of Traditional Chinese Medicine, China [XB2017032];
   Education Department of Fujian Province [JAT171164]
FX This study was funded by Fujian University of Traditional Chinese
   Medicine, China (XB2017032). This research also supported by The
   Education Department of Fujian Province(JAT171164).
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NR 29
TC 11
Z9 16
U1 0
U2 40
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD MAY
PY 2020
VL 39
AR 101170
DI 10.1016/j.ctcp.2020.101170
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LK5JF
UT WOS:000530901500042
PM 32379695
DA 2026-01-16
ER

PT J
AU Lu, LM
   Liao, MX
   Zeng, JC
   He, J
AF Lu, Liming
   Liao, Muxi
   Zeng, Jingchun
   He, Jun
TI Quality of reporting and its correlates among randomized controlled
   trials on acupuncture for cancer pain: application of the CONSORT 2010
   Statement and STRICTA
SO EXPERT REVIEW OF ANTICANCER THERAPY
LA English
DT Review
DE acupuncture; cancer pain; quality of reporting; randomized controlled
   trials; STRICTA; the CONSORT Statement
ID MANAGEMENT; RECOMMENDATIONS; IMPACT
AB This study aims to analyze the quality of reporting and its correlates in randomized controlled trials (RCTs) on acupuncture for cancer pain. Quality of reporting for included papers was assessed against a subset of criteria adapted from the CONSORT 2010 statement and STRICTA. An overall quality score (OQS) and a combined key methodologic index score (MIS) was calculated for each trial. Factors associated with OQS and MIS were then identified. A total of 32 RCTs were included in the full text. The median OQS based on the CONSORT Statement and STRICTA was 4.0 and 0, respectively. The significant predictors for CONSORT OQS were year of publication and nationality of authors, for STRICTA it was nationality of authors and for MIS it was publication language. The quality of reporting in RCTs on acupuncture for cancer pain was poor. This indicates that RCTs on acupuncture for cancer pain need substantial improvement.
C1 [Lu, Liming] Sun Yat Sen Univ, Sch Publ Hlth, Fac Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Liao, Muxi; He, Jun] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Acupuncture, Guangzhou 510405, Guangdong, Peoples R China.
   [Liao, Muxi] Guangzhou Univ Chinese Med, Guangzhou 510405, Guangdong, Peoples R China.
   [Zeng, Jingchun] People Hosp Pingyang, Dept Dermatol, Wenzhou 325400, Peoples R China.
C3 Sun Yat Sen University; Guangzhou University of Chinese Medicine;
   Guangzhou University of Chinese Medicine
RP Liao, MX (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Acupuncture, Guangzhou 510405, Guangdong, Peoples R China.
EM liaomuxi1@163.com
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NR 42
TC 23
Z9 25
U1 0
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7140
EI 1744-8328
J9 EXPERT REV ANTICANC
JI Expert Rev. Anticancer Ther
PD APR
PY 2013
VL 13
IS 4
BP 489
EP 498
DI 10.1586/ERA.13.27
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 133MD
UT WOS:000318141600017
PM 23560843
DA 2026-01-16
ER

PT J
AU Lee, JH
   Cho, TJ
   Park, MG
   Kim, JH
   Song, SK
   Park, SY
   Sunwoo, YY
   Lee, I
   Park, TY
AF Lee, Jin-Hyun
   Cho, Tae Jin
   Park, Min Geun
   Kim, Ji-Hoon
   Song, Sung Kyu
   Park, Shin-Young
   Sunwoo, Yun-Young
   Lee, Ilkyun
   Park, Tae-Yong
TI Clinical study on concurrent use of electro-acupuncture or Chuna manual
   therapy with pregabalin for chemotherapy-induced peripheral neuropathy:
   safety and effectiveness (open-labeled, parallel, randomized controlled
   trial, assessor-blinded) A study protocol
SO MEDICINE
LA English
DT Article
DE acupuncture; chemotherapy-induced peripheral neuropathy;
   electroacupuncture; manual medicine; pregabalin
ID QUALITY-OF-LIFE; AMERICAN SOCIETY; ONCOLOGY; QUESTIONNAIRE; ACUPUNCTURE;
   VALIDATION; MANAGEMENT; SURVIVORS; PATIENT
AB Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the major side effects of chemotherapy. Its main symptoms are pain, paresthesia, and numbness. However, the mechanisms underlying the development of CIPN remain unclear and standard treatments have not been established. Recently, there has been a growing interest in various approaches to overcome the limitations of the existing treatments. This study aims to evaluate the efficacy and safety of the concurrent use of two complementary and alternative therapies: electroacupuncture (EA) and Chuna manual therapy (CMT), with pregabalin, which is the conventional pharmacotherapy for neuropathic pain. Methods/design: This is an open-label, parallel, assessor-blinded randomized controlled trial, which includes 90 patients with colorectal and breast cancer, who developed CIPN. After a 2-week preparation period, the patients are divided into three groups (pregabalin administration group, pregabalin + EA treatment group, and pregabalin + CMT treatment group), treated for approximately 5 weeks and followed-up 4 weeks after treatment. The primary outcome is assessed using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity subscale score (version 4.0) and the secondary outcome is measured using the Quality of Life Questionnaire-CIPN 20-Item Scale (version 3.0) and the quality of life questionnaire (version 3.0) developed by the European Organisation for Research and Treatment of Cancer. Moreover, exploratory efficacy and safety evaluations will be conducted based on the chemotherapy-completion rate and nerve conduction studies.
C1 [Lee, Jin-Hyun; Park, Tae-Yong] Catholic Kwandong Univ Int, Inst Integrat Med, St Marys Hosp, Simgok Ro 100gil 25, Incheon 22711, South Korea.
   [Cho, Tae Jin; Lee, Ilkyun] Catholic Kwandong Univ Int, Dept Emergency Med, St Marys Hosp, Coll Med, Incheon, South Korea.
   [Park, Min Geun; Song, Sung Kyu; Park, Shin-Young] Catholic Kwandong Univ Int, Coll Med, Dept Surg, St Marys Hosp, Incheon, South Korea.
   [Kim, Ji-Hoon] Catholic Univ Korea, Incheon St Marys Hosp, Dept Surg, Incheon, South Korea.
   [Sunwoo, Yun-Young] Iksoodang Korean Med Clin, Incheon, South Korea.
C3 Catholic Kwandong University; Catholic Kwandong University; Catholic
   Kwandong University; Catholic University of Korea
RP Park, TY (corresponding author), Catholic Kwandong Univ Int, Inst Integrat Med, St Marys Hosp, Simgok Ro 100gil 25, Incheon 22711, South Korea.; Lee, I (corresponding author), Catholic Kwandong Univ Int, Dept Surg, St Marys Hosp, Simgok Ro 100gil 25, South Korea 22711, South Korea.
EM iklee68@gmail.com; parktae9822@gmail.com
RI Cho, Tae Jin/ADX-2223-2022
CR Argyriou AA, 2014, CANCER MANAG RES, V6, P135, DOI 10.2147/CMAR.S44261
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NR 26
TC 8
Z9 8
U1 3
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2020
VL 99
IS 3
AR e18830
DI 10.1097/MD.0000000000018830
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LB9LQ
UT WOS:000524950700068
PM 32011497
OA Green Published, gold
DA 2026-01-16
ER

PT J
AU Bao, T
   Zhi, WI
   Baser, RE
   Li, QS
   Weitzman, M
   Gillespie, EF
   Robson, M
   Mao, JJ
AF Bao, Ting
   Zhi, W. Iris
   Baser, Raymond E.
   Li, Q. Susan
   Weitzman, Matthew
   Gillespie, Erin F.
   Robson, Mark
   Mao, Jun J.
TI Electro-acupuncture versus battle field auricular acupuncture in breast
   cancer survivors with chronic musculoskeletal pain: subgroup analysis of
   a randomized clinical trial
SO BREAST CANCER RESEARCH AND TREATMENT
LA English
DT Article
DE Pain; Breast cancer; Acupuncture; Quality of life
ID AROMATASE INHIBITORS; WOMEN
AB Purpose Chronic musculoskeletal pain is common and debilitating among breast cancer survivors. The PEACE trial demonstrated that electro-acupuncture (EA) and battle field auricular acupuncture (BFAA) both reduced pain more than usual care (UC) in cancer survivors. However, the comparative effectiveness between EA and BFAA among breast cancer survivors is unknown.
   Methods EA and BFAA received ten weekly treatments. UC was offered ten EA treatments after week 12. The primary endpoint was change in mean Brief Pain Inventory (BPI) pain severity from baseline to week 12. We analyzed the subset of 165 (46%) trial participants with a breast cancer primary diagnosis. We conducted constrained linear mixed model analyses, which constrained all arms to a common pre-randomization baseline mean. Model-based mean estimates at weeks 12 and 24 were compared between arms using model contrasts.
   Results Among 165 breast cancer survivors, common pre-randomization mean pain severity was 5.35 [95% Confidence Interval (CI) 5.04, 5.66]. At week 12, BPI pain severity score was 2.69 (2.26. 3.13) in EA, 3.60 (3.17, 4.02) in BFAA, and 5.06 (4.47, 5.65) in UC. EA reduced pain severity significantly more than BFAA at weeks 12 [- 0.90 (- 1.45, - 0.36), p=0.001] and 24 [- 0.82, (- 1.38, - 0.27), p=0.004]. EA and BFAA significantly improved both Patient-Reported Outcomes Measurement Information System (PROMIS) - Global Health physical health and mental health component scores at week 12 compared to UC. Mild toxicities were reported.
   Conclusion EA was more effective than BFAA at reducing pain severity, but both similarly improved physical and mental health scores. Breast cancer survivors with chronic musculoskeletal pain may consider EA before BFAA.
C1 [Bao, Ting; Li, Q. Susan; Weitzman, Matthew; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.
   [Bao, Ting; Zhi, W. Iris; Robson, Mark] Mem Sloan Kettering Canc Ctr, Solid Tumor Div, Dept Med, Breast Med Serv, New York, NY 10065 USA.
   [Baser, Raymond E.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.
   [Gillespie, Erin F.] Univ Washington, Dept Radiat Oncol, Sch Med, Seattle, WA USA.
   [Bao, Ting] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 E 61st St,4th Floor, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; University of
   Washington; University of Washington Seattle; Memorial Sloan Kettering
   Cancer Center
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY 10065 USA.; Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Solid Tumor Div, Dept Med, Breast Med Serv, New York, NY 10065 USA.; Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 E 61st St,4th Floor, New York, NY 10065 USA.
EM tingbao@gmail.com
RI Gillespie, Erin/AAZ-8543-2021; Weitzman, Matthew/ITT-9808-2023
OI Bao, Ting/0000-0003-4437-2597
FU Department of Defense office of the Congressionally Directed Medical
   Research Programs through the Peer Reviewed Medical Research Program
   Clinical Trial Award [W81XWH-15-1-0245]; National Institutes of
   Health/National Cancer Institute (NIH/NCI) Cancer Center Support Grant
   [P30 CA008748]; NCI [R37 CA248563, 1 R01 CA240417, K08 CA252640];
   National Cancer Institute [K08CA252640, P30CA008748, R01CA240417,
   R37CA248563] Funding Source: NIH RePORTER
FX This work was supported by the Department of Defense office of the
   Congressionally Directed Medical Research Programs through the Peer
   Reviewed Medical Research Program Clinical Trial Award
   (W81XWH-15-1-0245). This work was also supported in part by a National
   Institutes of Health/National Cancer Institute (NIH/NCI) Cancer Center
   Support Grant P30 CA008748 to Memorial Sloan Kettering Cancer Center.
   Dr. Bao is supported in part by NCI R37 CA248563. Dr. Mao is supported
   in part by NCI 1 R01 CA240417. Dr. Gillespie is supported in part by NCI
   K08 CA252640.
CR American Cancer Society, 2022, Breast cancer
   Bao T, 2018, BREAST CANCER RES TR, V169, P133, DOI 10.1007/s10549-018-4670-9
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NR 23
TC 9
Z9 9
U1 1
U2 18
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0167-6806
EI 1573-7217
J9 BREAST CANCER RES TR
JI Breast Cancer Res. Treat.
PD NOV 23
PY 2023
VL 202
IS 2
BP 287
EP 295
DI 10.1007/s10549-023-07072-1
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA W6FP5
UT WOS:001092567600002
PM 37612534
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Santos, WBR
   Melo, MAO
   Alves, RS
   de Brito, RG
   Rabelo, TK
   Prado, LD
   Silva, VKD
   Bezerra, DP
   de Menezes, JER
   Souza, DS
   de Vasconcelos, CML
   Scotti, L
   Scotti, MT
   Junior, WD
   Quintans, LJ
   Guimaraes, AG
AF Santos, Wagner B. R.
   Melo, Marlange A. O.
   Alves, Rafael S.
   de Brito, Renan G.
   Rabelo, Thallita K.
   Prado, Lindaura da S.
   Silva, Virginia K. dos S.
   Bezerra, Daniel P.
   de Menezes-Filho, Jose E. R.
   Souza, Diego S.
   de Vasconcelos, Carla M. L.
   Scotti, Luciana
   Scotti, Marcus Tullius
   Junior, Waldecy de Lucca
   Quintans-Junior, Lucindo J.
   Guimaraes, Adriana G.
TI p-Cymene attenuates cancer pain via inhibitory pathways and
   modulation of calcium currents
SO PHYTOMEDICINE
LA English
DT Article
DE Natural products; Monoterpenes; Antinociceptive; Hyperalgesia; Cancer
   pain
ID INVOLVEMENT; CHANNELS; PHARMACOLOGY; CARVACROL; BONE
AB Background: Oncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-Cymene (PC) is a monoterpene found in more than 100 different plant species, endowed with various pharmacological properties-particularly antinociceptive.
   Hypothesis/Purpose: PC has antinociceptive effect in a model of oncologic pain due to the activation of the descending inhibitory pathway of pain.
   Study Design: A pre-clinical, longitudinal, blind and randomized study.
   Methods: Male Swiss mice were induced with S180 cells in the right hind paw, then treated daily with PC (12.5, 25 and 50 mg/kg, s.c.) and screened for mechanical hyperalgesia, spontaneous nociception, nociception induced by non-noxious palpation, tumor growth, changes in the neuromuscular function and existence of bone degradation in the tumor area. The effect of PC on Ca2+ currents (electrophysiological records), histological and neurochemical changes (immunofluorescence for Fos) were also evaluated.
   Results: PC reduced (p < 0.05) the mechanical hyperalgesia, the spontaneous (p < 0.001) and non-noxious palpation (p < 0.001) nociceptions, not changing the tumor development, neuromuscular function or histopathological aspects of the paw affected. PC reduced Fos expression in the spinal cord (p < 0.001) and increased this expression in the PAG (p < 0.05) and in the NRM (p < 0.01). PC decreased the density of calcium channel currents (p < 0.05).
   Conclusion: These results suggest the antinociceptive effect of PC on oncologic pain, probably acting in both ascending and descending pain pathways, and modulating the calcium channel currents in order to exert its effects.
C1 [Santos, Wagner B. R.; Melo, Marlange A. O.; Alves, Rafael S.; de Brito, Renan G.; Rabelo, Thallita K.; de Menezes-Filho, Jose E. R.; Souza, Diego S.; de Vasconcelos, Carla M. L.; Quintans-Junior, Lucindo J.] Univ Fed Sergipe, Dept Physiol, Sao Cristovao, Sergipe, Brazil.
   [Prado, Lindaura da S.] Univ Fed Sergipe, Postgrad Program Sci Appl Hlth, Lagarto, Sergipe, Brazil.
   [Silva, Virginia K. dos S.] Univ Fed Sergipe, Dept Odontol, Lagarto, Sergipe, Brazil.
   [Bezerra, Daniel P.] Fundacao Oswaldo Cruz, Lab Tissue Engn & Immunopharmacol, Salvador, BA, Brazil.
   [Scotti, Luciana; Scotti, Marcus Tullius] Univ Fed Paraiba, Joao Pessoa, Paraiba, Brazil.
   [Junior, Waldecy de Lucca] Univ Fed Sergipe, Dept Morphol, Sao Cristovao, Sergipe, Brazil.
   [Guimaraes, Adriana G.] Univ Fed Sergipe, Dept Hlth Educ, Padre Alvares Pitangueira St 248, BR-49400000 Lagarto, Sergipe, Brazil.
C3 Universidade Federal de Sergipe; Universidade Federal de Sergipe;
   Universidade Federal de Sergipe; Fundacao Oswaldo Cruz; Universidade
   Federal da Paraiba; Universidade Federal de Sergipe; Universidade
   Federal de Sergipe
RP Guimaraes, AG (corresponding author), Univ Fed Sergipe, Dept Hlth Educ, Padre Alvares Pitangueira St 248, BR-49400000 Lagarto, Sergipe, Brazil.
EM adrianagibara@pq.cnpq.br
RI Silva, Virginia/KGK-8565-2024; Brito, Renan/H-9584-2015; Guimarães,
   Aiana/G-6860-2014; Vasconcelos, Carla/F-3398-2019; Scotti, Marcus
   Tullius/G-2981-2012; Rabelo, Thallita Kelly/J-8810-2016; Menezes Filho,
   José Evaldo/AAW-7118-2021; SCOTTI, LUCIANA/C-7811-2013; Souza, Diego
   Santos/F-4024-2019; Quintans, Lucindo/A-2434-2012; SCOTTI,
   LUCIANA/G-2981-2012; Bezerra, Daniel/K-7889-2017
OI Guimarães, Aiana/0000-0003-1643-5642; Barbosa da Rocha Santos,
   Wagner/0000-0002-1922-4608; Scotti, Marcus Tullius/0000-0003-4863-8057;
   Rabelo, Thallita Kelly/0000-0002-9047-8133; Menezes Filho, José
   Evaldo/0000-0002-7547-8979; SCOTTI, LUCIANA/0000-0003-1866-4107; Souza,
   Diego Santos/0000-0002-3508-9776; Quintans, Lucindo/0000-0001-5155-938X;
   SCOTTI, LUCIANA/0000-0003-1866-4107; Bezerra, Daniel/0000-0002-6774-2063
FU Foundation for Research and Technological Innovation Support of the
   State of Sergipe (Fundacao de Apoio a Pesquisa e Inovacao Tecnologica do
   Estado de Sergipe/FAPITEC/SE); National Council of Technological and
   Scientific Development (Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico/CNPq/Brazil) [449667/2014-6]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES/Brazil)
FX We thank for the grants from the Foundation for Research and
   Technological Innovation Support of the State of Sergipe (Fundacao de
   Apoio a Pesquisa e Inovacao Tecnologica do Estado de
   Sergipe/FAPITEC/SE), the National Council of Technological and
   Scientific Development (Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico/CNPq/Brazil 449667/2014-6) and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES/Brazil).
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NR 39
TC 27
Z9 30
U1 1
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD AUG
PY 2019
VL 61
AR 152836
DI 10.1016/j.phymed.2019.152836
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA JH4HM
UT WOS:000492729600026
PM 31035053
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Kim, G
AF Kim, Gangmi
TI Electroacupuncture for postoperative pain and gastrointestinal motility
   after laparoscopic appendectomy (AcuLap): study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Electroacupuncture; Laparoscopic appendectomy; Postoperative pain;
   Postoperative gastrointestinal motility
ID CHEMOTHERAPY-INDUCED NAUSEA; COLORECTAL SURGERY; ENHANCED RECOVERY;
   PLACEBO-ACUPUNCTURE; CANCER; CARE; RADIOTHERAPY; METAANALYSIS;
   MANAGEMENT; PROGRAMS
AB Background: Acupuncture is a widely serviced complementary medicine. Although acupuncture is suggested for managing postoperative ileus and pain, supporting evidence is weak. The AcuLap trial is designed to provide high-level evidence regarding whether or not electroacupuncture is effective in promoting gastrointestinal motility and controlling pain after laparoscopic surgery.
   Methods/design: This study is a prospective randomized controlled trial with a three-arm, parallel-group structure evaluating the efficacy of electroacupuncture for gastrointestinal motility and postoperative pain after laparoscopic appendectomy. Patients with appendicitis undergoing laparoscopic surgery are included and randomized into three groups: 1) electroacupuncture group, 2) sham acupuncture group, and 3) control group. Patients receive 1) acupuncture with electrostimulation or 2) fake electroacupuncture with sham device twice a day or 3) no acupuncture after laparoscopic appendectomy. The primary outcome is time to first passing flatus after operation. Secondary outcomes include postoperative pain, analgesics, nausea/vomiting, bowel motility, time to tolerable diet, complications, hospital stay, readmission rates, time to recovery, quality of life, medical costs, and protocol failure rate. Patients and hospital staff (physicians and nurses) are blinded to which group the patient is assigned, electroacupuncture or sham acupuncture. Data analysis personnel are blinded to group assignment among all three groups. Estimated sample size to detect a minimum difference of time to first flatus with 80 % power, 5 % significance, and 10 % drop rate is 29 x 3 groups = 87 patients. Analysis will be performed according to the intention-to-treat principle.
   Discussion: The AcuLap trial will provide evidence on the merits and/or demerits of electroacupuncture for bowel motility recovery and pain relief after laparoscopic appendectomy.
C1 Dongguk Univ, Coll Med, Dept Surg, Gyeongju Si 780350, Gyeongsangbuk D, South Korea.
C3 Dongguk University
RP Kim, G (corresponding author), Dongguk Univ, Coll Med, Dept Surg, 87 Dongdae Ro, Gyeongju Si 780350, Gyeongsangbuk D, South Korea.
EM gangmikim@gmail.com
OI Kim, Gangmi/0000-0003-0688-1104
FU Daegu-Gyeongbuk Surgical Society research foundation, Korea
FX First, the author would like to thank Professor Gyeong-Ho Kim
   (Department of Acupuncture, Dongguk University Gyeongju Oriental
   Medicine Clinic) for his valuable contribution to the acupuncture
   practice. Also, I would like to thank Professor Kwan Lee (Department of
   Preventive Medicine, Dongguk University College of Medicine) for his
   support with statistics. I want to thank Professor Ki-Hun Jeong and
   Professor Ho-Geun Jeong (Department of Surgery, Dongguk University
   College of Medicine) for participating in the trial as attending
   surgeons. Finally, I want to thank all members of the Department of
   Surgery of Dongguk University Gyeongju Hospital for their cooperation.
   The AcuLap trial has been funded by a grant from the Daegu-Gyeongbuk
   Surgical Society research foundation, Korea, 2014.
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NR 41
TC 6
Z9 7
U1 1
U2 25
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD OCT 14
PY 2015
VL 16
AR 461
DI 10.1186/s13063-015-0981-x
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CT3MX
UT WOS:000362711900003
PM 26466590
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chang, XS
   Zhu, YJ
   Zhao, WJ
   Liu, YH
   He, YH
   Chen, YD
   Xu, DH
   Mao, JJ
   Zhang, HB
AF Chang, Xuesong
   Zhu, Yanjuan
   Zhao, Wenjie
   Liu, Yihong
   He, Yihan
   Chen, Yadong
   Xu, Danghan
   Mao, Jun J.
   Zhang, Hai-bo
TI Electro-acupuncture for health-related quality of life and symptoms in
   patients with gastric cancer undergoing adjuvant chemotherapy (EAGER): a
   protocol for a multicenter randomized controlled trial
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Acupuncture; Gastric cancer; Adjuvant chemotherapy; Health-related
   quality of life; Symptoms
ID UNDER-THE-CURVE; ENHANCE INTERPRETATION; CLINICAL-TRIAL; ACUPUNCTURE;
   GASTRECTOMY; THERAPY; FATIGUE; SYSTEM; SAFETY; PAIN
AB BackgroundPatients with local gastric cancer experience a decline of Health-related quality of life (HRQOL) during adjuvant chemotherapy following gastrectomy. Our previous pilot study has indicated the potential of acupuncture to improve HRQOL and control cancer-related symptoms burden. This full-scale trial will focus on confirming the effect of acupuncture for patients with gastric cancer.MethodsA multicenter, open-label, three-arm randomized controlled trial with 249 patients will be conducted in China. Patients will be randomly assigned, in a ratio of 1:1:1, to receive high-dose acupuncture (HA, 7 times each chemo-cycle for 3 cycles), low-dose acupuncture (LA, 3 times each chemo-cycle for 3 cycles), or no acupuncture. The acupoints prescription consisted of bilateral ST36, PC6, SP4, DU20, EX-HN3, and selected Back-shu points. Patients-reported Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) and modified Edmonton Symptom Assessment Scale (mESAS) during the therapy will be recorded. Area under curve (AUC, 21 days/cycle x 3 cycles) and average trajectory of FACT-Ga and mESAS will be calculated. The primary outcome will be the differences in AUC of the FACT-Ga Trial Outcome Index (TOI) between HA and LA versus control groups. Secondary outcomes include AUCs and average trajectory of other FACT-Ga subscales and mESAS scores.DiscussionThis study aims to assess the effect of acupuncture and to compare the difference between LA and HA groups on HRQOL and symptom burden controlling in gastric cancer patients by an adequately powered trial.
C1 [Chang, Xuesong; Zhu, Yanjuan; Liu, Yihong; He, Yihan; Chen, Yadong; Zhang, Hai-bo] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Dept Oncol, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Zhu, Yanjuan; Zhang, Hai-bo] Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.
   [Zhu, Yanjuan; Zhang, Hai-bo] Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China.
   [Zhao, Wenjie] Guangzhou Univ Chinese Med, Clin Med Sch 2, Guangzhou, Peoples R China.
   [Xu, Danghan] Guangzhou Univ Chinese Med, Rehabil Ctr, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, New York, NY 10065 USA.
   [Zhang, Hai-bo] Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Memorial Sloan Kettering Cancer Center;
   Guangzhou University of Chinese Medicine
RP Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Dept Oncol, Affiliated Hosp 2, Guangzhou, Peoples R China.; Zhang, HB (corresponding author), Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.; Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China.; Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, New York, NY 10065 USA.; Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
EM maoj@mskcc.org; haibozh@gzucm.edu.cn
RI Xu, Danghan/P-1067-2018; Chang, Xuesong/HGB-8879-2022
FU National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER;
   NCI NIH HHS [P30 CA008748] Funding Source: Medline
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NR 54
TC 3
Z9 4
U1 7
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JUL 11
PY 2023
VL 21
IS 1
AR 70
DI 10.1186/s12955-023-02135-9
PG 9
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA L9MY3
UT WOS:001026447200001
PM 37434165
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tang, J
   Sun, ZL
   Wang, Y
   Liu, J
   Wang, S
   Wang, XL
AF Tang, Jie
   Sun, Zhilu
   Wang, Yan
   Liu, Jing
   Wang, Shuai
   Wang, Xilian
TI Effect and Mechanism of Endothelin Receptor A Inhibitor BQ-123 Combined
   with Electroacupuncture on Tibia Cancer Pain in Rats
SO DISEASE MARKERS
LA English
DT Article
ID BONE; MODEL; PI3K/AKT; ETA
AB Objective. To research the impact and mechanism of endothelin receptor A inhibitor BQ-123 combined with electroacupuncture on tibia cancer pain in rats. Methods. Sprague-Dawley (SD) rats were randomly divided into sham group (SHAM group) and bone cancer pain model group (BCP group). The behavior of SD rats was measured. The histology of the right tibia was observed by hematoxylin-eosin (HE) staining. The remaining rats were randomly divided into model, BQ-123, electroacupuncture, and BQ123+ electroacupuncture group. Behavioral tests were performed, and mechanical pain threshold (MWT) and thermal pain threshold (TWL) were measured. The expressions of alpha-smooth muscle actin (alpha SMA), ETAR (endothelin A receptor), ETB (End of Transmission Block), P-Phosphatidylinositol 3-kinase (PI3K), and P-Protein kinase B (Akt) were detected by real-time fluorescence quantitative PCR and western blot. Results. In the BCP group, bone structure was severely damaged, local tissue swelling was obvious, bone trabecula was missing, and bone cortex was discontinuous. The optical density of Glial fibrillary acidic protein (GFAP) and CD11b immunoreactive signal in BCP group was significantly increased, and most of the ETAR of endothelin receptor was comapped with NeuN, and a small part of GFAP was comapped with CD11b, but no comapped with CD11b. The AS score of BQ-123+ electroacupuncture group was significantly lower than that of BQ-123 group and electroacupuncture group (P < 0.05), whereas the MWT and TWL values were significantly higher than that of the BQ-123 group and electroacupuncture group (P < 0.05). The mRNA expression of alpha-SMA and ETAR in BQ-123+ electroacupuncture group was lower than that in BQ-123 and electroacupuncture group, and the protein expression of P-PI3K and P-Akt in BQ123+ electroacupuncture group was lower as well. Conclusion. BQ-123 may inhibit the activation of PI3K/Akt signal path combined with electroacupuncture to alleviate the effects of tibia cancer pain in rats.
C1 [Tang, Jie; Wang, Xilian] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pain, Hengyang 421001, Peoples R China.
   [Sun, Zhilu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Emergency, Hengyang 421001, Peoples R China.
   [Wang, Yan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Peoples R China.
   [Liu, Jing] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil, Hengyang 421001, Peoples R China.
   [Wang, Shuai] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hand Foot Surg, Hengyang 421001, Peoples R China.
C3 University of South China; University of South China; University of
   South China; University of South China; University of South China
RP Wang, XL (corresponding author), Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pain, Hengyang 421001, Peoples R China.
EM 84093678@qq.com; 18673413301m0@sina.cn; 1009427308@qq.com;
   liujing724@163.com; 469969060@qq.com; 2018011762@usc.edu.cn
FU Natural Science Youth Foundation of Hunan [2021JJ40500]; Project of
   Hunan Provincial Health Commission [20200410]; Project of Education
   Department of Hunan Province [20C1613]
FX AcknowledgmentsThe paper is funded by the Natural Science Youth
   Foundation of Hunan (grant No. 2021JJ40500), Project of Hunan Provincial
   Health Commission (grant No. 20200410), and Project of Education
   Department of Hunan Province (grant No. 20C1613).
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NR 27
TC 2
Z9 4
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PD MAY 17
PY 2022
VL 2022
AR 8563202
DI 10.1155/2022/8563202
PG 9
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 3G2QD
UT WOS:000831199500002
PM 35620269
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Bao, T
   Zhi, WI
   Baser, R
   Li, Q
   Mao, J
AF Bao, Ting
   Zhi, W. Iris
   Baser, Raymond
   Li, Qing
   Mao, Jun
TI Effectiveness of Electroacupuncture Versus Auricular Acupuncture in
   Reducing Pain and Improving Quality of Life in Breast Cancer Survivors
   with Chronic Musculoskeletal Pain
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT San Antonio Breast Cancer Symposium
CY DEC 06-10, 2022
CL San Antonio, TX
NR 0
TC 1
Z9 1
U1 1
U2 13
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD MAR 1
PY 2023
VL 83
IS 5
SU S
MA PD8-05
DI 10.1158/1538-7445.SABCS22-PD8-05
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA I6XO5
UT WOS:001004196804068
DA 2026-01-16
ER

PT J
AU Dong, B
   Lin, L
   Chen, QY
   Qi, YS
   Wang, F
   Qian, KY
   Tian, L
AF Dong, Bei
   Lin, Lu
   Chen, Qiuyun
   Qi, Yishu
   Wang, Fen
   Qian, Keyan
   Tian, Li
TI Wrist-ankle acupuncture has a positive effect on cancer pain: a
   meta-analysis
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Wrist-ankle acupuncture; Pain; Cancer; Meta-analysis; Randomized
   controlled trial
AB Background: Wrist-ankle acupuncture (WAA) as a kind of micro acupuncture therapy has been used to management cancer pain, however, the effects of WAA on cancer pain were controversial in the current studies. Therefore, the purpose of this meta-analysis was to critically evaluate the effect of wrist-ankle acupuncture (WAA) on cancer pain.
   Methods: Seven digital databases were searched from the inception of databases to July 2020, including CNKI, Wanfang, VIP, CBM, Cochrane Library, PubMed and Embase. Randomized controlled trials conforming to the inclusion and exclusion criteria were screened and extracted; the risk of bias was evaluated using the Cochrane Collaboration criteria. The primary outcome indicators included pain relief rate and pain score, and the secondary outcome was adverse reaction incidence. All analyses were performed with Review Manager 5.3.
   Results: A total of 13 studies with 1005 cancer patients (intervention group: 568, control group: 437) were included in this meta-analysis. The results demonstrated that the pain relief rate of experimental group (WAA / WAA + drug intervention) was better than that of control group (analgesic drug intervention), and the difference was statistically significant [RR = 1.31, 95%CI: 1.15 similar to 1.49, P < 0.01].
   Conclusions: WAA has certain effect on cancer pain, and the effect of WAA combined with pharmacological intervention is better than that of drug therapy alone.
C1 [Dong, Bei; Chen, Qiuyun; Wang, Fen; Tian, Li] Soochow Univ, Affiliated Hosp 1, Oncol Dept, 188 Shizi Rd, Suzhou 215006, Peoples R China.
   [Lin, Lu; Qi, Yishu; Tian, Li] Soochow Univ, Sch Nursing, Med Coll, 188 Shizi Rd, Suzhou 215006, Peoples R China.
   [Qian, Keyan] Soochow Univ, Affiliated Hosp 1, Radiotherapy Dept, Suzhou, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China
RP Tian, L (corresponding author), Soochow Univ, Affiliated Hosp 1, Oncol Dept, 188 Shizi Rd, Suzhou 215006, Peoples R China.; Tian, L (corresponding author), Soochow Univ, Sch Nursing, Med Coll, 188 Shizi Rd, Suzhou 215006, Peoples R China.
EM tianlisz@suda.edu.cn
RI ; Lin, Lu/AAZ-3475-2021; QI, Yishu/LFT-4272-2024
OI , Li/0000-0002-6243-6331; Lin, Lu/0000-0002-2049-4605; 
FU National Natural Science Foundation of China [81801098]; Humanity and
   Social Science Youth Foundation of Ministry of Education of China
   [18YJCZH164]
FX This study was supported by National Natural Science Foundation of China
   (Grant No. 81801098) and the Humanity and Social Science Youth
   Foundation of Ministry of Education of China (Project No. 18YJCZH164).
   The funders had no role in the design of the study, or collection,
   analysis, and interpretation of data or in writing the manuscript.
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NR 32
TC 18
Z9 23
U1 1
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD JAN 7
PY 2021
VL 21
IS 1
AR 24
DI 10.1186/s12906-020-03193-y
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA PW1AU
UT WOS:000610409300005
PM 33413347
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Xie, SX
   Farrar, JT
   Stricker, CT
   Bowman, MA
   Bruner, D
   DeMichele, A
AF Mao, Jun J.
   Xie, Sharon X.
   Farrar, John T.
   Stricker, Carrie T.
   Bowman, Marjorie A.
   Bruner, Deborah
   DeMichele, Angela
TI A randomised trial of electro-acupuncture for arthralgia related to
   aromatase inhibitor use
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Article
DE Acupuncture; Breast neoplasm; Clinical trial; Aromatase inhibitors;
   Adverse effects; Musculoskeletal; Joint pain
ID ACUPUNCTURE; SYMPTOMS; DISCONTINUATION; MANAGEMENT
AB Background: Arthralgia is a common and debilitating side-effect experienced by breast cancer patients receiving aromatase inhibitors (AIs) and often results in premature drug discontinuation.
   Methods: We conducted a randomised controlled trial of electro-acupuncture (EA) as compared to waitlist control (WLC) and sham acupuncture (SA) in postmenopausal women with breast cancer who self-reported arthralgia attributable to AIs. Acupuncturists performed 10 EA/SA treatments over 8 weeks using a manualised protocol with 2 Hz electro-stimulation delivered by a TENS unit. Acupuncturists administered SA using Streitberger (non-penetrating) needles at non-traditional acupuncture points without electro-stimulation. The primary end-point was pain severity by Brief Pain Inventory (BPI) between EA and WLC at Week 8; durability of response at Week 12 and comparison of EA to SA were secondary aims.
   Findings: Of the 67 randomly assigned patients, mean reduction in pain severity was greater in the EA group than in the WLC group at Week 8 (-2.2 versus -0.2, p = 0.0004) and at Week 12 (-2.4 versus -0.2, p < 0.0001). Pain-related interference measured by BPI also improved in the EA group compared to the WLC group at both Week 8 (-2.0 versus 0.2, p = 0.0006) and Week 12 (-2.1 versus -0.1, p = 0.0034). SA produced a magnitude of change in pain severity and pain-related interference at Week 8 (-2.3, -1.5 respectively) and Week 12 (-1.7, -1.3 respectively) similar to that of EA. Participants in both EA and SA groups reported few minor adverse events.
   Interpretations: Compared to usual care, EA produced clinically important and durable improvement in arthralgia related to AIs in breast cancer patients, and SA had a similar effect. Both EA and SA were safe. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Mao, Jun J.] Univ Penn, Dept Family Med & Community Hlth, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Xie, Sharon X.; Farrar, John T.; DeMichele, Angela] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Xie, Sharon X.; Farrar, John T.; DeMichele, Angela] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Farrar, John T.; Stricker, Carrie T.; DeMichele, Angela] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Bowman, Marjorie A.] Wright State Univ, Sch Med, Dayton, OH 45435 USA.
   [Bruner, Deborah] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania; University System of Ohio;
   Wright State University Dayton; Emory University
RP Mao, JJ (corresponding author), Univ Penn, Dept Family Med & Community Hlth, 3400 Spruce St 2 Gates, Philadelphia, PA 19104 USA.
EM jun.mao@uphs.upenn.edu
RI Farrar, John/AAP-4788-2021; Mao, Jun/F-5009-2012; Xie,
   Sharon/JCO-7144-2023; bowman, marjorie/F-7235-2013
OI Stricker, Carrie/0000-0002-6468-8540; bowman,
   marjorie/0000-0002-1945-9212; Bruner, Deborah/0000-0002-5770-9948
FU National Institutes of Health/National Center for Complementary and
   Alternative Medicine (NCCAM) [R21 AT004695]; NCCAM [K23 AT004112]
FX This study is supported by grants from the National Institutes of
   Health/National Center for Complementary and Alternative Medicine
   (NCCAM) R21 AT004695. Dr. Mao is a recipient of the NCCAM K23 AT004112
   award. The funding agencies had no role in the design or conduct of the
   study. Dr. Mao had full access to all the data in the study and had
   final responsibility for the decision to submit for publication.
CR [Anonymous], J SOC INTEGR ONCOL
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NR 31
TC 107
Z9 125
U1 0
U2 46
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-8049
EI 1879-0852
J9 EUR J CANCER
JI Eur. J. Cancer
PD JAN
PY 2014
VL 50
IS 2
BP 267
EP 276
DI 10.1016/j.ejca.2013.09.022
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 293PV
UT WOS:000329986500003
PM 24210070
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Lin, LL
   Wang, YH
   Lai, CY
   Chau, CL
   Su, GC
   Yang, CY
   Lou, SY
   Chen, SK
   Hsu, KH
   Lai, YL
   Wu, WM
   Huang, JL
   Liao, CH
   Juan, HF
AF Lin, Li-Ling
   Wang, Ya-Hui
   Lai, Chi-Yu
   Chau, Chan-Lao
   Su, Guan-Chin
   Yang, Chun-Yi
   Lou, Shu-Ying
   Chen, Szu-Kai
   Hsu, Kuan-Hao
   Lai, Yen-Ling
   Wu, Wei-Ming
   Huang, Jian-Long
   Liao, Chih-Hsin
   Juan, Hsueh-Fen
TI Systems Biology of Meridians, Acupoints, and Chinese Herbs in Disease
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID PROSTATE-CANCER CELLS; GENE-EXPRESSION; PROTEOMIC ANALYSIS; AMERICAN
   GINSENG; MEDICINAL HERB; UNCARIA-RHYNCHOPHYLLA; ACUPUNCTURE TREATMENT;
   MICROARRAY ANALYSIS; PARKINSONS-DISEASE; NEUROPATHIC PAIN
AB Meridians, acupoints, and Chinese herbs are important components of traditional Chinese medicine (TCM). They have been used for disease treatment and prevention and as alternative and complementary therapies. Systems biology integrates omics data, such as transcriptional, proteomic, and metabolomics data, in order to obtain a more global and complete picture of biological activity. To further understand the existence and functions of the three components above, we reviewed relevant research in the systems biology literature and found many recent studies that indicate the value of acupuncture and Chinese herbs. Acupuncture is useful in pain moderation and relieves various symptoms arising from acute spinal cord injury and acute ischemic stroke. Moreover, Chinese herbal extracts have been linked to wound repair, the alleviation of postmenopausal osteoporosis severity, and anti-tumor effects, among others. Different acupoints, variations in treatment duration, and herbal extracts can be used to alleviate various symptoms and conditions and to regulate biological pathways by altering gene and protein expression. Our paper demonstrates how systems biology has helped to establish a platform for investigating the efficacy of TCM in treating different diseases and improving treatment strategies.
C1 [Lin, Li-Ling; Lou, Shu-Ying; Lai, Yen-Ling; Liao, Chih-Hsin; Juan, Hsueh-Fen] Natl Taiwan Univ, Dept Life Sci, Taipei 106, Taiwan.
   [Wang, Ya-Hui; Lai, Chi-Yu] Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei 100, Taiwan.
   [Chau, Chan-Lao] Natl Taiwan Univ, Dept Bioenvironm Syst Engn, Taipei 106, Taiwan.
   [Su, Guan-Chin; Yang, Chun-Yi] Natl Taiwan Univ, Inst Biochem Sci, Taipei 106, Taiwan.
   [Chen, Szu-Kai; Hsu, Kuan-Hao; Juan, Hsueh-Fen] Natl Taiwan Univ, Inst Mol & Cellular Biol, Taipei 106, Taiwan.
   [Wu, Wei-Ming] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei 106, Taiwan.
   [Huang, Jian-Long; Juan, Hsueh-Fen] Natl Taiwan Univ, Grad Inst Biomed Elect & Bioinformat, Taipei 106, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University; National Taiwan University;
   National Taiwan University; National Taiwan University
RP Juan, HF (corresponding author), Natl Taiwan Univ, Dept Life Sci, 1,Sect 4,Roosevelt Rd, Taipei 106, Taiwan.
EM yukijuan@ntu.edu.tw
RI Wu, Wei-Ming/MGA-0819-2025; Yang, Chunyi/HSB-0167-2023; Wang,
   Yahui/JCO-6233-2023
OI Wu, Wei-Ming/0000-0001-5998-0478; JUAN, HSUEH-FEN/0000-0003-4876-3309;
   Smith, Lillian/0000-0001-9891-5900; CHAU, CHAN LAO/0000-0001-6487-1858; 
FU National Taiwan University Cutting-Edge Steering Research Project
   [101R7602C3]; National Science Council of Taiwan
   [NSC99-2621-B-010-001-MY3, NSC99-2621-B-002-005-MY3]
FX This work was supported by the National Taiwan University Cutting-Edge
   Steering Research Project (101R7602C3) and the National Science Council
   of Taiwan (NSC99-2621-B-010-001-MY3, and NSC99-2621-B-002-005-MY3).
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NR 116
TC 18
Z9 22
U1 0
U2 42
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 372670
DI 10.1155/2012/372670
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 026NS
UT WOS:000310287200001
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Lu, WD
   Rosenthal, DS
AF Lu, Weidong
   Rosenthal, David S.
TI Oncology Acupuncture for Chronic Pain in Cancer Survivors: A Reflection
   on the American Society of Clinical Oncology Chronic Pain Guideline
SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Oncology acupuncture; ASCO practice guideline; Chronic pain; Cancer
   survivors
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER; INTEGRATIVE ONCOLOGY;
   COMPLEMENTARY THERAPIES; ARTHRALGIA; MANAGEMENT; WOMEN;
   ELECTROACUPUNCTURE; STIMULATION; SYMPTOMS
AB Chronic pain syndromes associated with cancer treatment are common but difficult to manage. The American Society of Clinical Oncology recently published a practice guideline to address the unmet needs of cancer survivors, Management of Chronic Pain in Survivors of Adult Cancers, which stresses the importance of implementing integrative therapies, including acupuncture. This article focuses on randomized clinical trials of acupuncture for chronic pain in cancer survivors, including its use in chemotherapy-induced peripheral neuropathy, aromatase inhibitor associated arthralgia, and post neck dissection pain, and provides future directions of oncology acupuncture research in cancer survivorship. The features of oncology acupuncture are also discussed.
C1 [Lu, Weidong; Rosenthal, David S.] Harvard Med Sch, Leonard P Zakim Ctr Integrat Therapies & Hlth Liv, Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute
RP Lu, WD (corresponding author), Harvard Med Sch, Leonard P Zakim Ctr Integrat Therapies & Hlth Liv, Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA.
EM weidong_lu@dfci.harvard.edu
FU Asia-Pacific Cancer Research Fund
FX This work is partially supported by Asia-Pacific Cancer Research Fund.
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NR 43
TC 25
Z9 26
U1 0
U2 36
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8588
EI 1558-1977
J9 HEMATOL ONCOL CLIN N
JI Hematol. Oncol. Clin. North Am.
PD JUN
PY 2018
VL 32
IS 3
BP 519
EP +
DI 10.1016/j.hoc.2018.01.009
PG 16
WC Oncology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology
GA GI8DW
UT WOS:000434753000015
PM 29729786
DA 2026-01-16
ER

PT J
AU Lin, MN
   Li, XH
   Liang, WN
   Liu, JH
   Guo, JH
   Zheng, JX
   Liu, XX
AF Lin, Munan
   Li, Xihai
   Liang, Wenna
   Liu, Jianhua
   Guo, Jianhong
   Zheng, Jingxiong
   Liu, Xianxiang
TI Needle-knife therapy improves the clinical symptoms of knee
   osteoarthritis by inhibiting the expression of inflammatory cytokines
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE needle-knife therapy; acupuncture; knee joint; osteoarthritis
ID COLLAGEN GENE-EXPRESSION; CARTILAGE DEGRADATION; CHONDROCYTES; DISEASE;
   ACUPUNCTURE; SUPPRESSION; CHINESE; ALPHA; FLUID; RISK
AB Knee osteoarthritis (KOA) is a degenerative joint disease that occurs mainly in the elderly population. However, there are currently no effective treatments for treating this condition. In this study, the efficacy of needle-knife therapy, a technique of traditional Chinese medicine that has been widely used to treat KOA was investigated. Patients (n=170) with KOA were randomly divided for needle-knife therapy (treatment group) and acupuncture therapy (control group). Outcome evaluation included stiffness, pain, physiological function, overall changes, total symptom score, clinical curative effects and the concentrations of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the synovial fluid. The trial was completed in 151 patients (233 knees) from a total of 170 patients (264 knees); the treatment group comprised 76 patients (117 knees) who completed the trial and 9 patients (14 knees) who were removed from the study, and the control group comprised 75 patients (116 knees) who completed the trial and 10 patients (17 knees) who were removed from the study. The symptom scores of KOA in stages I-IV were reduced significantly in the treatment group and those of stages I-III were decreased significantly in the control group. The effective rate of the KOA therapy in the patients of stages III and IV in the treatment group was significantly higher than that in the control group. After treatment, the decrements of IL-1 beta, IL-6 and TNF-alpha in the treatment group were greater than those in the control group. These results showed that the use of needle-knife therapy to treat KOA effectively improved the clinical symptoms by inhibiting the expression of inflammatory cytokines.
C1 [Lin, Munan; Liu, Jianhua; Guo, Jianhong; Zheng, Jingxiong] Nanjing Mil Command, Dept Tradit Chinese Med, Fuzhou Gen Hosp, Fuzhou 350025, Fujian, Peoples R China.
   [Li, Xihai; Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China.
   [Liang, Wenna] Fujian Univ Tradit Chinese Med, Res Base Tradit Chinese Med Syndrome, Fuzhou 350122, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Liu, JH (corresponding author), Nanjing Mil Command, Dept Tradit Chinese Med, Fuzhou Gen Hosp, Outpatient Bldg,156 Xierhuanbei Rd, Fuzhou 350025, Fujian, Peoples R China.
EM lmnan_fzzyy@126.com
RI Li, Xihai/NUQ-4105-2025
FU National Natural Science Foundation of China [81102609]; Natural Science
   Foundation of Fujian Province [2011J05074]
FX This study was supported by the National Natural Science Foundation of
   China (grant no. 81102609) and the Natural Science Foundation of Fujian
   Province (grant no. 2011J05074).
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NR 36
TC 28
Z9 37
U1 4
U2 46
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD APR
PY 2014
VL 7
IS 4
BP 835
EP 842
DI 10.3892/etm.2014.1516
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AE9BP
UT WOS:000334299200013
PM 24669238
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, MC
AF Wang, Mei-Chen
TI ACUPUNCTURE FOR CANCER PAIN MANAGEMENT
SO ONCOLOGY NURSING FORUM
LA English
DT Meeting Abstract
C1 [Wang, Mei-Chen] NYU, New York, NY USA.
C3 New York University
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD MAR
PY 2021
VL 48
IS 2
BP 89
EP 89
PG 1
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA QK4IE
UT WOS:000620349200321
DA 2026-01-16
ER

PT J
AU Zhi, WI
   Mao, JJ
   Baser, RE
   Li, SQ
   Blinder, VS
   Norton, L
   Seidman, AD
   Robson, ME
   Bao, T
AF Zhi, Wanqing Iris
   Mao, Jun J.
   Baser, Raymond E.
   Li, Susan Q.
   Blinder, Vicotria S.
   Norton, Larry
   Seidman, Andrew D.
   Robson, Mark E.
   Bao, Ting
TI Effectiveness of electroacupuncture versus auricular acupuncture in
   breast cancer survivors with chronic musculoskeletal pain: The PEACE
   randomized clinical trial
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT San Antonio Breast Cancer Symposium
CY DEC 07-10, 2021
CL San Antonio, TX
SP Amer Assoc Cancer Res, Mays Cancer Ctr, UT Hlth San Antonio MD Anderson Cancer Ctr, Mays Cancer Ctr
NR 0
TC 0
Z9 0
U1 5
U2 14
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD FEB 15
PY 2022
VL 82
IS 4
SU S
MA P4-08-01
DI 10.1158/1538-7445.SABCS21-P4-08-01
PG 3
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA ZY5SY
UT WOS:000772647602144
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Liou, K
   Panageas, K
   Baser, RE
   Romero, SAD
   Li, QS
   Xiao, H
   Bao, T
   Kantoff, PW
AF Mao, Jun J.
   Liou, Kevin
   Panageas, Katherine
   Baser, Raymond E.
   Romero, Sally A. D.
   Li, Qing Susan
   Xiao, Han
   Bao, Ting
   Kantoff, Philip W.
TI Effects of electroacupuncture and auricular acupuncture for chronic pain
   in cancer survivors: The PEACE randomized controlled trial.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
CY MAY 29-31, 2020
CL ELECTR NETWORK
SP Amer Soc Clin Oncol
C1 Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA USA.
   Mem Sloan Kettering Canc Ctr, Basking Ridge, NJ USA.
   Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; University of Pennsylvania;
   Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
FU Department of Defense U.S. National Institutes of Health
FX Department of Defense U.S. National Institutes of Health
NR 0
TC 2
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2020
VL 38
IS 15
SU S
MA 12004
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology
GA NB2UL
UT WOS:000560368300429
DA 2026-01-16
ER

PT J
AU Chien, TJ
   Chang, YI
   Liao, LL
   Hsu, YN
   Huang, CW
AF Chien, Tsai-Ju
   Chang, Yuan-I.
   Liao, Li-Lan
   Hsu, Yu-Ni
   Huang, Chien-Wen
TI Comparative Efficacy of Low-Level Laser Acupuncture and
   Electroacupuncture in Women With Dysmenorrhea and Autonomic Imbalance: A
   Pilot Randomized-Controlled Trial
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Article
DE autonomic dysfunction; dysmenorrhea; electroacupuncture; heart rate
   variation; low-level laser acupuncture
ID HEART-RATE-VARIABILITY; QUALITY-OF-LIFE; KUAN-SIN-YIN; THERAPY;
   ACUPRESSURE; SYMPTOMS; CANCER; PAIN
AB Background Electroacupuncture (EA) has been widely applied in treating dysmenorrhea and autonomic dysfunction. Low-level laser acupuncture (LLLA), a noninvasive acupuncture, has been used clinically, but efficacy is uncertain. This study aimed to explore the efficacy of LLLA, EA, and sham-controlled LLLA on pain, heart rate variability (HRV) activity, and symptom improvement in dysmenorrhea with autonomic imbalance. Method In a randomized, controlled design, a total of 114 women with dysmenorrhea and autonomic imbalance were randomly allocated to three groups: sham LLLA, LLLA, and EA. The primary outcomes are pain (VAS), and HRV parameters, and the secondary outcomes are symptom assessment (verbal multidimensional scoring system), prostaglandin E, progesterone levels, and the SF-12 quality-of-life assessment. Results Contrast to the sham acupuncture, LLLA and EA effectively reconciled the pain and sympathetic/parasympathetic tone significantly, no matter the vagus or sympathetic deviated status (low or high LF/HF group). LLLA was superior to EA in terms of SDNN, RMMSD, and PNN50 (p < 0.001) in the low LF/HF group in intergroup analysis. For all participants' analysis, the effects of LLLA and EA were similar for pain assessment (VAS) and quality of life (SF-12) (p < 0.05). In proinflammatory cytokine measurement, EA showed a significant decrease in prostaglandin E2 (PGE2) levels (p = 0.022). Conclusion This pilot study showed both LLLA and EA effectively relieve dysmenorrhea without a placebo effect, LLLA is noninferior to EA in autonomic dysfunction, and the effect is even more prominent in low LF/HF status (a relatively lower energy status). Given its noninvasiveness, LLLA could be an alternative treatment and warrants further large-scale study.
C1 [Chien, Tsai-Ju; Hsu, Yu-Ni] Taipei City Hosp, Dept Internal Med, Div Hematooncol, Branch Zhong Xing, Taipei, Taiwan.
   [Chien, Tsai-Ju; Liao, Li-Lan] Natl Yang Ming Chiao Tung Univ, Inst Tradit Med, Taipei, Taiwan.
   [Chang, Yuan-I.] Natl Yang Ming Chiao Tung Univ, Dept & Inst Physiol, Coll Med, Taipei, Taiwan.
   [Liao, Li-Lan] Taipei City Hosp, Dept Tradit Med, Branch Kunming, Taipei, Taiwan.
   [Huang, Chien-Wen] Sunhawk Vis Biotech Inc, Taipei, Taiwan.
C3 Taipei City Hospital; National Yang Ming Chiao Tung University; National
   Yang Ming Chiao Tung University; Taipei City Hospital
RP Chien, TJ (corresponding author), Taipei City Hosp, Dept Internal Med, Div Hematooncol, Branch Zhong Xing, Taipei, Taiwan.; Chien, TJ (corresponding author), Natl Yang Ming Chiao Tung Univ, Inst Tradit Med, Taipei, Taiwan.
EM silence021@gmail.com
OI Chien, Tsai Ju/0000-0001-9646-5272; Chang, Yuan-I/0000-0002-2035-2818
FU Ministry of Science and Technology of the People's Republic of China
FX We thank all authors and participants in this study and the authors we
   have contacted who provided us with the information of their trials.
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NR 52
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PY 2025
VL 2025
IS 1
AR 3494216
DI 10.1155/prm/3494216
PG 14
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8YC9P
UT WOS:001600103300001
PM 41179650
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Saw, CLL
   Chew, L
   Goh, C
AF Saw, Constance L. L.
   Chew, Lita
   Goh, Cynthia
TI Recent Non-Interventional Advances in Cancer Pain and Singaporean
   Patients
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Review
DE Cancer outpatients; Complementary therapies; Non-pharmacological pain
   treatments; Pain prevalence
ID CELIAC PLEXUS BLOCK; ALTERNATIVE MEDICINE; DATA METAANALYSIS;
   ACUPUNCTURE; MANAGEMENT; MASSAGE; COMPLEMENTARY; THERAPIES; ONCOLOGY;
   ELECTROACUPUNCTURE
AB Introduction: Pain is a common symptom in cancer patients, but very little information about the prevalence, severity, and treatment of pain in cancer patients in Singapore is available. Therefore, our prospective survey in the National Cancer Centre (NCC) outpatients is incorporated in this report. In addition, a review concerning the recent advances on non-interventional pain management in cancer treatment, which is relevant in the context, is discussed. Materials and Methods: For the prospective survey, a questionnaire was distributed for self-administration by patients while waiting for consultation at the NCC outpatient departments. Literature searches on advances in pain management were conducted, reviewed and discussed. Results: In the last decade, there have been advances in pain pharmacology ranging from wider therapeutic options and management approaches to novel delivery techniques. Acupuncture and massage therapy became increasingly popular among cancer patients. Some clinical trials of acupuncture show benefits in palliation of cancer pain. From the prospective survey, 41.2% of the responders reported pain in the past week, and only 70.8% talked to their doctors about their pain. One third of the patients received analgesics. Of these, 86.5% said that they were taking the prescribed medications, however, 37.4% admitted to having difficulties taking them. Non-drug methods were used by 25.4% of the patients. Medicated oil, cream or gel was used by 49.3%; only 2.6% reported use of Chinese herbs. Conclusion: Pain is a significant symptom in outpatients attending a cancer centre, affecting 41.2% of the patients. Although majority of patients who suffered from pain reported this to doctors, much more medical effort is needed to help patients to relieve their pain and proper complementary therapy could be considered.
C1 [Saw, Constance L. L.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA.
   [Saw, Constance L. L.; Chew, Lita] Natl Canc Ctr, Dept Pharm, Singapore, Singapore.
   [Goh, Cynthia] Natl Canc Ctr, Dept Palliat Med, Singapore, Singapore.
C3 Rutgers University System; Rutgers University New Brunswick; National
   Cancer Centre Singapore (NCCS); National Cancer Centre Singapore (NCCS)
RP Saw, CLL (corresponding author), Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM constancesaw@gmail.com
RI Saw, Constance/B-3959-2018
OI Saw, Constance/0000-0002-7631-8395
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NR 57
TC 1
Z9 2
U1 0
U2 13
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD SEP
PY 2012
VL 41
IS 9
BP 407
EP 416
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 024HI
UT WOS:000310099900006
PM 23052435
DA 2026-01-16
ER

PT J
AU Zeng, JC
   Zhang, RL
   Wei, XJ
   Lin, GH
AF Zeng, Jing-chun
   Zhang, Rui-lin
   Wei, Xiao-jing
   Lin, Guo-hua
TI Acupuncture for improving a case of widespread herpes zoster after
   non-Hodgkin's lymphoma chemotherapy
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Herpes zoster; Varicella Zoster Virus; Acupuncture; Alternative therapy;
   Chemotherapy; Non-Hodgkin's lymphoma
AB Background: Herpes zoster presents as clustered blisters on one side of the body, accompanied by nerve pain. This is caused by reactivation of the varicella zoster virus, and it occurs primarily in people with weakened immunity. Tumor and chemotherapy drugs can impair the patient's immune function, induce herpes zoster and prolong the course of disease.In these patients, skin changes can last for months and blisters can recur and cause serious complications such as postherpetic neuralgia.Acupuncture is a common alternative therapy for herpes zoster in East Asia.
   Case presentation: We report a case of an elderly male patient with widespread herpes zoster in the trunk after non-Hodgkin's lymphoma chemotherapy. The patient had received conventional treatment with valaciclovir and mecobalamin within 24 hours of symptom onset. Because neither the clustered blisters nor the nerve pain were improved a week later, acupuncture and related techniques were applied. These included electro-acupuncture, surrounding acupuncture, fire acupuncture, and cupping. The patient recovered 20 days after the herpes zoster attack, and there were no adverse reactions during the treatment process.
   Conclusions: This case suggests that acupuncture and related techniques are effective interventions for this condition.This case report is innovative because it shows that acupuncture as an adjuvant treatment can improve the skin lesions in patients with HZ after tumour chemotherapy, relieve pain, and shorten the course of HZ. (C) 2021 The Authors. Published by Elsevier Inc.
C1 [Zeng, Jing-chun; Zhang, Rui-lin; Lin, Guo-hua] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Wei, Xiao-jing] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zeng, JC; Lin, GH (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
EM tcm_zjc@126.com; tcmlin-801@163.com
RI Wei, Xiaojing/AFM-6584-2022; zhang, ruilin/J-5074-2013
FU National Natural Science Foundation of China [81574061]; Guangdong
   Science and TechnologyCommission Foundation [2017A020213019]; Scientific
   Research Foundation of the First Affiliated Hospital of Guangzhou
   Uniersity of Chinese Medicine [2019QN23]
FX The National Natural Science Foundation of China (No. 81574061), the
   Guangdong Science and TechnologyCommission Foundation (No.
   2017A020213019) and Scientific Research Foundation of the First
   Affiliated Hospital of Guangzhou Uniersity of Chinese Medicine
   (2019QN23) provided funding.
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NR 9
TC 3
Z9 4
U1 2
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD SEP-OCT
PY 2022
VL 18
IS 5
BP 608
EP 611
DI 10.1016/j.explore.2021.08.003
EA AUG 2022
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 4Q4FF
UT WOS:000856038100021
PM 34417113
OA hybrid
DA 2026-01-16
ER

PT J
AU Li, Y
   Wu, F
   Wei, JZ
   Lao, LX
   Shen, XY
AF Li, Yuan
   Wu, Fan
   Wei, Jianzi
   Lao, Lixing
   Shen, Xueyong
TI Laser Moxibustion Alleviates Knee Osteoarthritis Pain by Inhibiting
   Spinal Microglial Activation-Mediated Neuroinflammation in Rats
SO PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
LA English
DT Article
DE laser moxibustion; knee osteoarthritis pain; neuroinflammation; glial
   activation
ID MONOSODIUM IODOACETATE MODEL; CENTRAL SENSITIZATION; ACUPUNCTURE
AB Background: Central sensitization driven by glial activation-mediated neuroinflammation is recognized as a key mechanism in pain processing. Laser moxibustion using low-intensity laser irradiation of corresponding acupoints significantly relieves knee osteoarthritis (KOA) pain. However, the underlying mechanism of its effects on KOA pain is still not completely understood. Objective: In this study, we aimed to investigate whether laser moxibustion could alleviate KOA pain by inhibiting spinal glial activation and proinflammatory cytokines upregulation in monosodium iodoacetate (MIA)-induced KOA pain in rats. Materials and methods: Sprague-Dawley rats were divided randomly into three groups: Saline + Sham Laser, MIA + Laser, and MIA + Sham Laser. A 10.6 mu m laser was used to irradiate ST35 (Dubi) for 10 min once every 2 days for a total of seven applications. The paw withdrawal mechanical threshold and weight-bearing distribution were performed to evaluate the nociceptive behaviors. Spinal expressions of microglial marker, ionized calcium binding adaptor molecule-1 (Iba-1); astrocyte marker, glial fibrillary acidic protein (GFAP); pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) were measured 14 days after MIA injection. Results: The results showed that laser moxibustion significantly reversed the MIA-induced mechanical hyperalgesia and weight-bearing difference up to 14 days compared with MIA + Sham Laser group (p < 0.05 or p < 0.01). Moreover, both the protein level and immunofluorescence intensity of Iba-1 in the ipsilateral spinal cord dorsal horn were markedly decreased in the MIA + Laser group than those in the MIA + Sham Laser group (p < 0.01). However, there was no significant difference in the expression of GFAP between groups (p > 0.05). In addition, laser moxibustion decreased the upregulation of TNF-alpha, IL-1 beta, and IL-6 compared with the MIA + Sham Laser group (p < 0.01). Conclusions: This study demonstrated that laser moxibustion at ST35 significantly alleviated MIA-induced KOA pain through inhibition of the microglial activation-mediated neuroinflammation, at least partially, by suppressing the production of proinflammatory cytokines, which may provide a potential analgesic target for KOA pain relief.
C1 [Li, Yuan; Wu, Fan; Wei, Jianzi; Lao, Lixing; Shen, Xueyong] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Room 9415,1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Lao, Lixing] Univ Hong Kong, Sch Chinese Med, Hong Kong, Peoples R China.
   [Shen, Xueyong] Shanghai Res Ctr Acupuncture & Meridian, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; University of Hong
   Kong
RP Shen, XY (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Room 9415,1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM snowysh@hotmail.com
RI Lao, Lixing/P-9107-2019
FU National Natural Science Foundation of China [2015CB554505]; Shanghai
   Key Laboratory of Acupuncture Mechanism and Acupoint function
   [14DZ2260500]; Shanghai University of Traditional Chinese Medicine
   Budget Research Project [18LK010]; Li Yuan's Postgraduate Innovation
   Ability Project [A1-N192050102040105]
FX This research was financially supported by the National Natural Science
   Foundation of China (No. 2015CB554505), Shanghai Key Laboratory of
   Acupuncture Mechanism and Acupoint function (No. 14DZ2260500), Shanghai
   University of Traditional Chinese Medicine Budget Research Project (No.
   18LK010), and Li Yuan's Postgraduate Innovation Ability Project (No.
   A1-N192050102040105).
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NR 36
TC 9
Z9 12
U1 0
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
EI 2578-5478
J9 PHOTOBIOMOD PHOTOMED
JI Photobiomodulation Photomed. Laser Surg.
PD APR 1
PY 2020
VL 38
IS 4
BP 237
EP 243
DI 10.1089/photob.2019.4744
EA JAN 2020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LE4IX
UT WOS:000509226300001
PM 31976816
DA 2026-01-16
ER

PT J
AU Gondim, DV
   Costa, JL
   Rocha, SS
   Brito, GAD
   Ribeiro, RD
   Vale, ML
AF Gondim, Delane Viana
   Costa, Jessyca Lima
   Rocha, Suellen Sousa
   de Castro Brito, Gerly Anne
   Ribeiro, Ronaldo de Albuquerque
   Vale, Mariana Lima
TI Antinociceptive and anti-inflammatory effects of electroacupuncture on
   experimental arthritis of the rat temporomandibular joint
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE acupuncture; electroacupuncture; temporomandibular joint; arthritis;
   zymosan; nociception; inflammation
ID NEUROPEPTIDE-LIKE IMMUNOREACTIVITY; RANDOMIZED CONTROLLED-TRIAL;
   ZYMOSAN-INDUCED ARTHRITIS; NITRIC-OXIDE; EXPERIMENTAL INDUCTION;
   COMPLEMENT ACTIVATION; RHEUMATOID-ARTHRITIS; TRIGEMINAL NUCLEUS;
   MYOFASCIAL PAIN; FOS EXPRESSION
AB This study investigated the antinociceptive and anti-inflammatory effects of electroacupuncture (EA) on zymosan-induced acute arthritis of the rat temporomandibular joint (TMJ). Male Wistar rats were injected with saline or zymosan (control group; 2 mg) into the left TMJ. Low frequency EA (10 Hz, 30 min) was performed at acupoints (LI4, LI11, ST36, ST44) or sham points 2 h after or 1 h before zymosan administration. Mechanical hypernociception was accessed by the electronic Von Frey method after zymosan administration. Rats were sacrificed 6 h after zymosan administration and the joint was removed for histopathological analysis, myeloperoxidase activity assessment, vascular permeability observations, and immunohistochemical verification of inflammatory mediators. The results showed that EA inhibited zymosan-induced hypernociception, compared with the control group and with the sham group (p < 0.05). The results showed that EA inhibited inflammatory parameters such as neutrophil migration, vascular permeability, and tumour necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) expression in the TMJ compared with the sham group (p < 0.05). Histopathological analysis showed that EA significantly inhibited edema and periarticular infiltration (p < 0.05) compared with the control and sham groups. EA at acupoints produced antinociceptive and anti-inflammatory effects on zymosan-induced arthritis in the rat TMJ.
C1 [Gondim, Delane Viana; Costa, Jessyca Lima; Rocha, Suellen Sousa; Ribeiro, Ronaldo de Albuquerque; Vale, Mariana Lima] Fed Univ Ceara UFC, Fac Med, Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, Brazil.
   [de Castro Brito, Gerly Anne] Fed Univ Ceara UFC, Fac Med, Dept Morphol, BR-60430170 Fortaleza, Ceara, Brazil.
C3 Universidade Federal do Ceara; Universidade Federal do Ceara
RP Gondim, DV (corresponding author), Fed Univ Ceara UFC, Fac Med, Dept Physiol & Pharmacol, Rua Colonel Nunes de Melo 1127, BR-60430270 Fortaleza, Ceara, Brazil.
EM delanegondim@yahoo.com.br
RI Gondim, Delane/N-9555-2017; Vale, Mariana/AAH-9843-2020; de Castro
   Brito, Gerly Anne/C-8597-2013
OI Gondim, Delane/0000-0002-7240-3314; Vale, Mariana/0000-0003-2120-411X;
   de Castro Brito, Gerly Anne/0000-0002-8214-4379
FU Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico
   (FUNCAP); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES)
FX The authors gratefully acknowledge the technical assistance of Maria
   Silvandira Franca Pinheiro and Maria do Socorro Fran a Monte. This work
   was supported by grants from Fundacao Cearense de Apoio ao
   Desenvolvimento Cientifico e Tecnologico (FUNCAP) and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES).
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NR 71
TC 21
Z9 23
U1 0
U2 16
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD APR
PY 2012
VL 90
IS 4
BP 395
EP 405
DI 10.1139/Y2012-003
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 918HY
UT WOS:000302241200004
PM 22443108
DA 2026-01-16
ER

PT J
AU Chen, J
   Fu, TX
   Liu, L
   Xie, YR
   Li, YD
AF Chen, Jiu
   Fu, Tianxiao
   Liu, Li
   Xie, Yirui
   Li, Youdi
TI Effect of acupuncture inclusion in the enhanced recovery after surgery
   protocol on tumor patient gastrointestinal function: a systematic review
   and meta-analysis of randomized controlled studies
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE acupuncture; tumor; enhanced recovery after surgery; meta-analysis;
   gastrointestinal function
ID POSTOPERATIVE NAUSEA; ORGAN DYSFUNCTION; MECHANISMS; EFFICACY; SAFETY
AB Introduction Acupuncture has been shown to be effective in restoring gastrointestinal function in tumor patients receiving the enhanced recovery after surgery (ERAS) protocol. The present systematic review and meta-analysis aimed to evaluate the rationality and efficacy of integrating acupuncture in the ERAS strategy to recuperate gastrointestinal function.Methods We searched eleven databases for relevant randomized clinical trials (RCTs) of acupuncture for the treatment of gastrointestinal dysfunction in tumor patients treated with the ERAS protocol. The quality of each article was assessed using the Cochrane Collaboration risk of bias criteria and the modified Jadad Scale. As individual symptoms, the primary outcomes were time to postoperative oral food intake, time to first flatus, time to first distension and peristaltic sound recovery time (PSRT). Pain control, adverse events, and acupoint names reported in the included studies were also investigated.Results Of the 211 reviewed abstracts, 9 studies (702 patients) met eligibility criteria and were included in the present systematic review and meta-analysis. Compared to control groups, acupuncture groups showed a significant reduction in time to postoperative oral food intake [standardized mean difference (SMD) = -0.77, 95% confidence interval (CI) -1.18 to -0.35], time to first flatus (SMD=-0.81, 95% CI -1.13 to -0.48), time to first defecation (SMD=-0.91, 95% CI -1.41 to -0.41, PSRT (SMD=-0.92, 95% CI -1.93 to 0.08), and pain intensity (SMD=-0.60, 95% CI -0.83 to -0.37).The Zusanli (ST36) and Shangjuxu (ST37) acupoints were used in eight of the nine included studies. Adverse events related to acupuncture were observed in two studies, and only one case of bruising was reported.Discussion The present systematic review and meta-analysis suggested that acupuncture significantly improves recovery of gastrointestinal function and pain control in tumor patients receiving the ERAS protocol compared to the control group. Moreover, ST36 and ST37 were the most frequently used acupoints. Although the safety of acupuncture was poorly described in the included studies, the available data suggested that acupuncture is a safe treatment with only mild side effects. These findings provide evidence-based recommendations for the inclusion of acupuncture in the ERAS protocol for tumor patients.
C1 [Chen, Jiu; Fu, Tianxiao; Li, Youdi] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Tradit Chinese Med, Hangzhou, Peoples R China.
   [Liu, Li] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Lib, Hangzhou, Peoples R China.
   [Xie, Yirui] Natl Clin Res Ctr Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Dis, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Peoples R China.
   [Xie, Yirui] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Infect Dis, Hangzhou, Peoples R China.
C3 Zhejiang University; Zhejiang University; Collaborative Innovation
   Center for Diagnosis & Treatment of Infectious Diseases; Zhejiang
   University
RP Chen, J (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Tradit Chinese Med, Hangzhou, Peoples R China.
EM chenjiu1982@163.com
FU This study was supported by the Natural Science Foundation of Zhejiang
   Province (award no:LBY22H270001).; Natural Science Foundation of
   Zhejiang Province;  [LBY22H270001]
FX The authors thank Charlesworth Author Services for editing the article.r
   This study was supported by the Natural Science Foundation of Zhejiang
   Province (award no:LBY22H270001).
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NR 66
TC 6
Z9 7
U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD AUG 15
PY 2023
VL 13
AR 1232754
DI 10.3389/fonc.2023.1232754
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA Q4NW4
UT WOS:001057313800001
PM 37655096
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Dai, N
   Liu, XH
   Wan, HJ
AF Dai, Nan
   Liu, Xiaohui
   Wan, Hejia
TI Practical Applications and Safety of Battlefield Acupuncture for Pain
   Management: A Systematic Literature Review
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Review
DE pain management; acupuncture therapy; analgesics
ID EAR ACUPUNCTURE; THERAPY; CANCER
AB Background: Pain is complex and subjective, causing physical and psychological damage. Western medical treatments are prone to dependence, gastrointestinal problems, and organ damage. Battlefield acupuncture (BFA) integrates traditional Chinese medicine with contemporary military medicine, achieving a rapid analgesic effect. In the domain of pain management, it is effective. Despite controversy, it is recommended as an analgesic for pain populations. Purpose: The present study evaluated the clinical efficacy and safety of BFA, with a view to informing pain management strategies and validating its credibility. Methods: Databases including PubMed, Cochrane Library, Web of Science, and Embase were searched from 2015-2025. Randomized controlled studies(RCTs) on BFA for pain were included. Outcome measurements were pain scores and adverse event rates. Two authors independently assessed studies using the Cochrane risk of bias tool for randomized trials(RoB-1). Heterogeneity was addressed via narrative synthesis. Results: Of 800 articles screened, 11 RCTs (n=1,232; BFA: 530 patients) matched criteria. BFA was compared with opioids, non-opioids, exercise or physical therapies for various types of pain. Four studies reported lower BFA pain scores, and four found no difference. No severe adverse event rates were noted, but mild reactions were recorded. RoB grades: two A, eight B, Conclusion: Evidence supports the efficacy and safety of BFA for acute pain. The utilisation of BFA in the context of alleviating mild to moderate pain is recommended, particularly in conjunction with electroacupuncture therapies.However, limitations include small sample sizes, blinding issues, and inconsistent protocols. Research into specific pain types and long-term efficacy should be focused on.
C1 [Dai, Nan; Liu, Xiaohui; Wan, Hejia] Henan Univ Chinese Med, Sch Nursing, Smart Healthcare Ind, Nursing Sch, Zhengzhou, Peoples R China.
   [Liu, Xiaohui] Henan Univ Tradit Chinese Med, Henan Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Zhengzhou, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine
RP Liu, XH (corresponding author), Henan Univ Chinese Med, Sch Nursing, Smart Healthcare Ind, Nursing Sch, Zhengzhou, Peoples R China.; Liu, XH (corresponding author), Henan Univ Tradit Chinese Med, Henan Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Zhengzhou, Peoples R China.
EM 1173652033@qq.com
RI Wan, Hejia/IWD-9214-2023
OI Wan, Hejia/0009-0003-3900-1967
FU The 2023 Chinese Medicine Culture and Management Research Program of
   Henan Provincial Health Commission [TCM2023009]; The 2023 Professional
   Degree Graduate Student Fine Teaching Case Project of Education
   Department of Henan Province [YJS2023AL053]; The 2022 Chinese Medicine
   Clinical Research Base Special Projects of Henan Provincial Health
   Commission [2021JDZX2032]; The 2020 Chinese Medicine Scientific Research
   Special Projects of Henan Provincial Health Commission [20-21ZY2113]
FX This study was supported by the 2023 Chinese Medicine Culture and
   Management Research Program of Henan Provincial Health Commission (Grant
   No. TCM2023009) , the 2023 Professional Degree Graduate Student Fine
   Teaching Case Project of Education Department of Henan Province (Grant
   No. YJS2023AL053) , the 2022 Chinese Medicine Clinical Research Base
   Special Projects of Henan Provincial Health Commission (Grant No.
   2021JDZX2032) , the 2020 Chinese Medicine Scientific Research Special
   Projects of Henan Provincial Health Commission (Grant No. 20-21ZY2113) .
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NR 43
TC 2
Z9 2
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2025
VL 18
BP 2749
EP 2769
DI 10.2147/JMDH.S517946
PG 21
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 2VS5N
UT WOS:001492456300001
PM 40401079
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU He, Y
   Xiang, ST
   Zhang, DJ
   Chen, MZ
AF He, Yi
   Xiang, Shate
   Zhang, Danjun
   Chen, Muzhi
TI Acupuncture treatment for liver cancer pain: A meta-analysis
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Review
DE acupuncture; liver cancer; meta-analysis; pain; systematic review
ID QUALITY-OF-LIFE; HEPATOCELLULAR-CARCINOMA; MANAGEMENT; MECHANISMS
AB Acupuncture treatment is a common intervention for the clinical relief of primary liver cancer (PLC) pain, but there is variability in its efficacy. This review systematically assessed the efficacy and safety of acupuncture treatment for PLC pain by meta-analysis. A total of 17 randomized controlled trial studies involving 1162 patients met the inclusion criteria. This study identified the acupuncture method, treatment duration, and patient age were the main factors affecting the efficacy of acupuncture treatment.
C1 [He, Yi; Xiang, Shate] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou, Peoples R China.
   [Zhang, Danjun; Chen, Muzhi] Zhejiang Chinese Med Univ, Dept Rheumatol, Affiliated Hosp 2, Hangzhou 310005, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Chen, MZ (corresponding author), Zhejiang Chinese Med Univ, Dept Rheumatol, Affiliated Hosp 2, Hangzhou 310005, Peoples R China.
EM cmzxhyy@zcmu.edu.cn
OI He, Yi/0009-0009-3043-5404
FU Zhejiang Traditional Chinese Medicine Administration;  [GZY-ZJ-KJ-23016]
FX This study was supported by the grants of Zhejiang Traditional Chinese
   Medicine Administration (No. GZY-ZJ-KJ-23016).
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NR 60
TC 2
Z9 2
U1 7
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD JUL
PY 2024
VL 130
IS 1
BP 83
EP 92
DI 10.1002/jso.27691
EA MAY 2024
PG 10
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA ZD2T1
UT WOS:001226851800001
PM 38764249
OA Bronze
DA 2026-01-16
ER

PT J
AU Soylu, D
   Kartin, PT
AF Soylu, Dilek
   Kartin, Pinar Tekinsoy
TI The effect on gastrointestinal system functions, pain and anxiety of
   acupressure applied following laparoscopic cholecystectomy operation: A
   randomised, placebo-controlled study
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Laporascopic cholecystectomy; Acupressure; Gastrointestinal system
   functions; Anxiety; Pain; Nursing
ID POSTOPERATIVE ILEUS; GASTRIC-CANCER; ACUPUNCTURE; STIMULATION;
   GASTRECTOMY; DEPRESSION; SURGERY; NAUSEA
AB The aim of this randomised, placebo-controlled, 3-way blinded study was to determine the effect on GIS symptoms, pain and anxiety of acupressure applied for a total of 12 min, as 3 min at each of the ST25, CV12, TH6, and HT7 acupuncture points, at 0, 4 and 8 h after laparoscopic cholecystectomy operation. The research data were collected using a patient data collection form, the Numeric Pain Intensity Scale and the State-Trait Anxiety Inventory. The patients were evaluated in respect of the time to first flatus and defecation, pain and the State-Trait Anxiety points at 0, 4, and 8 h postoperatively. The application of acupressure was determined to have signficantly reduced acute postoperative pain and shortened the time to defecation (p < 0.05). The application of acupressure can be recommended in the nursing interventions following laparoscopic cholecystectomy to reduce acute pain and shorten the time to defecation.
C1 [Soylu, Dilek] Erciyes Univ, Inst Hlth Sci, Surg Nursing, Kayseri, Turkey.
   [Kartin, Pinar Tekinsoy] Erciyes Univ, Fac Hlth Sci, Nursing Dept, Kayseri, Turkey.
C3 Erciyes University; Erciyes University
RP Soylu, D (corresponding author), Kahramanmaras Sutcu Imam Univ, Hlth Practice & Res Hosp, Kahramanmaras, Turkey.
EM dsoylu@ksu.edu.tr; ptekinsoy@erciyes.edu.tr
RI soylu, dilek/KIH-8902-2024
OI soylu, dilek/0000-0002-9580-3804
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NR 47
TC 19
Z9 21
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD MAY
PY 2021
VL 43
AR 101304
DI 10.1016/j.ctcp.2021.101304
EA FEB 2021
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RY1WM
UT WOS:000647709400001
PM 33540298
DA 2026-01-16
ER

PT J
AU Li, ZL
   Xiong, QW
   Li, SW
   Chen, WX
   Xu, NG
   Qiu, FH
AF Li, Zeli
   Xiong, Qianwen
   Li, Shuwen
   Chen, Wenxiang
   Xu, Nenggui
   Qiu, Fanghua
TI RETRACTED: Quantitative analysis and visualization of literature on
   acupuncture and related TCM therapies for the treatment of colorectal
   cancer based on CiteSpace (Retracted article. See vol. 15, 2025)
SO FRONTIERS IN ONCOLOGY
LA English
DT Article; Retracted Publication
DE acupuncture; colorectal cancer; Citespace; literature measurement;
   visualization analysis
ID SURGERY
AB Objective We analyzed the literature describing the results of treatment of colorectal cancer (CRC) using acupuncture in the past three decades from the Web of Science (WoS) and Chinese databases (including CNKI, WANGFANG and VIP), and summarized the current development of CRC treatment as well as future research directions through the presentation of maps and visualization analysis. Methods We searched the WoS and Chinese databases. Relevant articles were exported, and the data were organized using Excel software and was visualized and analyzed using CiteSpace software. Results A total of 355 articles from the WoS and 95 articles from Chinese databases were selected for inclusion in the analysis. The articles in WoS were sourced from 174 journals, 1274 institutions, and 66 countries, and covered 299 keywords. The articles in the Chinese databases were sourced from 43 journals, 111 institutions, and 3 countries, and included 126 keywords. The article with the most citations in the WoS was cited 128 times and in the Chinese databases, the article with the most citations was cited 120 times. Acupuncture, CRC, rectal cancer, apoptosis, warm acupuncture, traditional Chinese medicine (TCM) and gastrointestinal function were mentioned most frequently in the WoS. CRC, electroacupuncture, gastrointestinal function, rectal cancer, acupuncture and moxibustion, acupuncture, and colon cancer were mentioned most frequently in the Chinese databases. Conclusion Both the WoS and Chinese databases showed a gradual increase in the number of articles related to acupuncture treatment for CRC, indicating a growing interest in this area. Acupuncture treatments are diverse, including warm acupuncture, auricular acupuncture, acupuncture injection, and electroacupuncture. They are often used in combination with drugs to treat symptoms such as depression, nausea and vomiting, pain, diarrhea, and urinary and fecal incontinence, which are commonly associated with CRC.
C1 [Li, Zeli; Xu, Nenggui] Guangzhou Univ Chinese Med, Clin Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.
   [Xiong, Qianwen; Li, Shuwen] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
   [Chen, Wenxiang] Guangzhou Med Univ, Affiliated TCM Hosp, Guangzhou, Peoples R China.
   [Qiu, Fanghua] Guangzhou Hosp Tradit Chinese Med, Dept Infect Control, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou Medical University; Guangzhou University of
   Chinese Medicine
RP Xu, NG (corresponding author), Guangzhou Univ Chinese Med, Clin Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.; Qiu, FH (corresponding author), Guangzhou Hosp Tradit Chinese Med, Dept Infect Control, Guangzhou, Peoples R China.
EM ngxu8018@gzucm.edu.cn; qiufanghua1976@163.com
RI li, zeli/KCL-1589-2024
FU Guangdong Provincial Department of Science and
   Technology10.13039/501100007162
FX No Statement Available
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NR 35
TC 5
Z9 7
U1 4
U2 82
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JAN 5
PY 2024
VL 13
AR 1290588
DI 10.3389/fonc.2023.1290588
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FI9X2
UT WOS:001145260400001
PM 38250554
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, LJ
   Xu, T
   Sun, MS
   Wan, SP
   Ying, J
   Luo, L
   Fan, Y
   Yang, Y
   You, FM
   Hu, BY
   Li, QY
   Yan, WL
   Wang, YH
   Yu, X
   Yuan, Y
   Gao, XY
   Zhao, L
AF Wang, Linjia
   Xu, Tao
   Sun, Mingsheng
   Wan, Shaoping
   Ying, Jian
   Luo, Lun
   Fan, Yi
   Yang, Yong
   You, Fengming
   Hu, Binyu
   Li, Qiuyue
   Yan, Wanlin
   Wang, Yuhan
   Yu, Xin
   Yuan, Yu
   Gao, Xiaoyu
   Zhao, Ling
TI Electro-acupuncture for gastrointestinal dysfunction after colorectal
   cancer surgery: A protocol for three-arm randomized controlled trial
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Colorectal cancer; Electro-acupuncture; Postoperative gastrointestinal
   dysfunction; Protocol; Randomized controlled trial
ID QUALITY-OF-LIFE; POSTOPERATIVE MORBIDITY SURVEY; LAPAROSCOPIC SURGERY;
   ENHANCED RECOVERY; COLONIC SURGERY; ILEUS; ACUPUNCTURE; ANALGESIA;
   OUTCOMES
AB Introduction: Postoperative gastrointestinal dysfunction (POGD) is one of the most common complications after colorectal cancer (CRC) surgery and seriously affects the prognosis of patients. Furthermore, current clinical treatment measures have controversial efficacy or strong side effects. Electro-acupuncture (EA) is a safe therapeutic modality for POGD; however, high-quality evidence is scarce at present. This study will aim to evaluate the efficacy and safety of EA for POGD in patients with CRC.Methods: A total of 270 patients with POGD after CRC surgery will be recruited from five hospitals in China and assigned to EA, sham electro-acupuncture (SA), and routine treatment (RT) groups in a 1:1:1 ratio. Patients in the RT group will receive treatment based on enhanced recovery after surgery (ERAS), health education, and routine care. Patients in the EA and SA groups will be treated with EA or SA on the basis of RT, respectively, from postoperative days one to three, once per day. Follow-up will be performed at seven and fourteen days after surgery. The primary outcome is the time to the first postoperative passing flatus. Secondary outcomes include the following: time of first postoperative bowel movement, postoperative bowel sound recovery time, gastro-intestinal symptom rating scale, I-FEED (intake, feeling nauseated, emesis, physical exam, duration of symptoms) scale, postoperative surgical site pain degree, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30 (V3.0)), EORTC Quality of Life Questionnaire -Colorectal Cancer 29 (EORTC QLQ-CR29), postoperative complications, adverse acupuncture events, etc.Discussion: This study design is rigorous, and a scientific placebo acupuncture method is used. The advantages are (1) multi-center, prospective, large sample randomized control with strict quality control; (2) the placebo control method can minimize the true acupuncture effect on the basis of blinding patients as much as possible; (3) the gastrointestinal function and quality of life of POGD patients after passing flatus and defecation will be analyzed. Conclusion: The findings of the 3-arm clinical trial will demonstrate whether EA is effective and safe for patients with POGD after CRC surgery.Trial registration: ChiCTR2200062275 (registered on 31-07-2022).
C1 [Wang, Linjia; Xu, Tao; Sun, Mingsheng; Hu, Binyu; Li, Qiuyue; Yan, Wanlin; Wang, Yuhan; Yuan, Yu; Gao, Xiaoyu; Zhao, Ling] Chengdu Univ Tradit Chinese Med, Sch Acu Mox & Tuina, 37 Shi Er Qiao Rd, Chengdu 610075, Peoples R China.
   [Wan, Shaoping] Sichuan Canc Hosp & Inst, 55,Sect 4,South Renmin Rd, Chengdu 610041, Peoples R China.
   [Ying, Jian; Fan, Yi] Chongqing Hosp Tradit Chinese Med, 6 Panxiqizhi Rd, Chongqing 400021, Peoples R China.
   [Luo, Lun; Yu, Xin] Chengdu Second Peoples Hosp, 10 South Qingyun St, Chengdu 610021, Peoples R China.
   [Yang, Yong] Deyang Peoples Hosp, 173 North Taishan Rd, Deyang 618099, Peoples R China.
   [You, Fengming] Hosp Chengdu Univ Tradit Chinese Med, 39 Shi Er Qiao Rd, Chengdu 610075, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Zhao, L (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Acu Mox & Tuina, 37 Shi Er Qiao Rd, Chengdu 610075, Peoples R China.; Ying, J (corresponding author), Chongqing Hosp Tradit Chinese Med, 6 Panxiqizhi Rd, Chongqing 400021, Peoples R China.
EM 329924692@qq.com; zhaoling@cdutcm.edu.cn
RI YAN, WANLIN/IAQ-2773-2023
OI Wang, Linjia/0000-0002-3333-2189
FU Sichuan Province Science and Technology Support Program [2021ZYD0103,
   BSH2023018]; Chengdu University of Traditional Chinese Medicine "Xinglin
   Scholars" Discipline Talent Research Promotion Plan-Postdoctoral
   Program;  [2020YFS0304]
FX This work was financially supported by the Sichuan Province Science and
   Technology Support Program (No. 2020YFS0304; No. 2021ZYD0103) and
   Chengdu University of Traditional Chinese Medicine "Xinglin Scholars"
   Discipline Talent Research Promotion Plan-Postdoctoral Program (No.
   BSH2023018) . The sponsors have no roles in the design of the study;
   collection, analysis and interpretation of data; and writing of the
   manuscript.
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   Ye Z, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271580
   Zerillo JA, 2017, JAMA ONCOL, V3, P686, DOI 10.1001/jamaoncol.2017.0417
   Zhang ZD, 2014, ACUPUNCT MED, V32, P223, DOI 10.1136/acupmed-2013-010490
   Zhong F., 2013, PhD dissertation
NR 54
TC 1
Z9 1
U1 3
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD SEP
PY 2023
VL 62
AR 102277
DI 10.1016/j.eujim.2023.102277
EA AUG 2023
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA Q7MR5
UT WOS:001059333800001
OA hybrid
DA 2026-01-16
ER

PT J
AU Bao, YJ
   Kong, XY
   Yang, LP
   Liu, R
   Shi, Z
   Li, WD
   Hua, BJ
   Hou, W
AF Bao, Yanju
   Kong, Xiangying
   Yang, Liping
   Liu, Rui
   Shi, Zhan
   Li, Weidong
   Hua, Baojin
   Hou, Wei
TI Complementary and Alternative Medicine for Cancer Pain: An Overview of
   Systematic Reviews
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID QUALITY-OF-LIFE; BREAST-CANCER; METHODOLOGICAL QUALITY; MEASUREMENT
   TOOL; PROSTATE-CANCER; MASSAGE; REFLEXOLOGY; ACUPUNCTURE; THERAPIES;
   EFFICACY
AB Background and Objective. Now with more and more published systematic reviews of Complementary and Alternative Medicine (CAM) on adult cancer pain, it is necessary to use the methods of overview of systematic review to summarize available evidence, appraise the evidence level, and give suggestions to future research and practice. Methods. A comprehensive search (the Cochrane Library, PubMed, Embase, and ISIWeb of Knowledge) was conducted to identify all systematic reviews or meta-analyses of CAM on adult cancer pain. And the evidence levels were evaluated using GRADE approach. Results. 27 systematic reviews were included. Based on available evidence, we could find that psychoeducational interventions, music interventions, acupuncture plus drug therapy, Chinese herbal medicine plus cancer therapy, compound kushen injection, reflexology, lycopene, TENS, qigong, cupping, cannabis, Reiki, homeopathy (Traumeel), and creative arts therapies might have beneficial effects on adult cancer pain. No benefits were found for acupuncture (versus drug therapy or shame acupuncture), and the results were inconsistent for massage therapy, transcutaneous electric nerve stimulation (TENS), and Viscum album L plus cancer treatment. However, the evidence levels for these interventions were low or moderate due to high risk of bias and/or small sample size of primary studies. Conclusion. CAM may be beneficial for alleviating cancer pain, but the evidence levels were found to be low or moderate. Future large and rigor randomized controlled studies are needed to confirm the benefits of CAM on adult cancer pain.
C1 [Bao, Yanju; Liu, Rui; Shi, Zhan; Li, Weidong; Hua, Baojin; Hou, Wei] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beijing 100053, Peoples R China.
   [Kong, Xiangying] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
   [Yang, Liping] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Nephrol, Beijing 100053, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS; Guang'anmen Hospital, CACMS; China Academy of Chinese
   Medical Sciences
RP Hua, BJ (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beixiange 5, Beijing 100053, Peoples R China.
EM huabaojin1@163.com; houweipu@163.com
FU National Natural Science Foundation of China [81273718, 81302961]
FX This work was partially supported by the National Natural Science
   Foundation of China (no. 81273718 and no. 81302961). Yanju Bao and
   Liping Yang are the cofirst authors.
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NR 71
TC 67
Z9 92
U1 0
U2 108
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 170396
DI 10.1155/2014/170396
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AG1EX
UT WOS:000335159000001
PM 24817897
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Balneaves, LG
   Lee, RT
   Guns, EST
   Zick, SM
   Bauer-Wu, S
   Greenlee, H
AF Balneaves, Lynda G.
   Lee, Richard T.
   Guns, Emma S. Tomlinson
   Zick, Suzanna M.
   Bauer-Wu, Susan
   Greenlee, Heather
TI Tenth International Conference of the Society for Integrative Oncology
   Translational Science in Integrative Oncology: From Bedside to Bench to
   Best Practices
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
AB 107: The Effect of Two Types of Self-Administered Acupressure Compared to Standard of Care on Depression and Anxiety in Fatigued Breast Cancer SurvivorsBackground: There are nearly 3 million breast cancer survivors (BCS) in the United States. Mood disorders in BCS are common, with 38% of women having moderate to high anxiety, and 22% having moderate to high depression. Depression may interfere with survivors' quality of life, decreased adherence to adjuvant therapy and be associated with lower rates of survival. Current treatments for mood disorders can be difficult to implement and/or have unacceptable side effects; thus, there is a need for new treatments in this area. Methods: We compared the effect of 6 weeks of 2 types of self-administered acupressure (stimulating [SA] and relaxing [RA]) versus standard of care (SC) in 32 women for depression, and in 57 women with anxiety who reported 8 at baseline on the Hospital Anxiety Depression Scale (HADS) depression or anxiety subscales, as appropriate, and who were from an ongoing randomized clinical trial on acupressure for persistent cancer-related fatigue in BCS. Analyses of variance (ANOVA) were performed on mean differences of changes (baseline to week 6) in anxiety and depression subscales by group. Results: There was a significant decrease in depression (P = .02 vs SA; P = .06 vs SC) but not in anxiety (P = .36 vs SA; P = .46 vs SC) in the RA group compared with either SA or SC. This represents a -47% mean decrease from baseline in depression in the RA group versus -16% in the SA group and 22% in the SC group, and on average a movement from being borderline abnormal on the HADS depression subscale at baseline (9.2 0.98, 0-21 point scale) to normal (4.9 2.7) at 6 weeks. Conclusion: In this preliminary analysis, self-administered RA engenders a greater antidepressive response as compared with either SA or SC in fatigued BCS. These findings should be interpreted with caution given our small sample size. More rigorous studies are recommended.
   Abstract 67: Electro-Acupuncture for Aromatase Inhibitor-Related Arthralgia and Comorbid Symptoms in Breast Cancer Survivors: A Randomized Placebo-Controlled TrialBackground: Arthralgia and comorbid symptoms (e.g., fatigue, insomnia) are common among breast cancer patients receiving aromatase inhibitors (AIs). Methods: We conducted a randomized, placebo-controlled trial of electro-acupuncture compared with wait-list control (WLC) and sham acupuncture in postmenopausal women with breast cancer who self-attributed their arthralgia to taking AIs. Acupuncturists delivered 10 treatments of tailored acupuncture with 2-Hz electrostimulation via a TENS (transcutaneous electrical nerve stimulation) unit. Sham acupuncture was conducted using nonpenetrating Streitberger needles at nontraditional acupuncture points and lacked electrostimulation. The primary endpoint was pain severity measured by Brief Pain Inventory (BPI) between electro-acupuncture and WLC at week 8; durability of response at week 12; and comparison of electro-acupuncture to sham acupuncture were secondary aims. Results: Sixty-seven patients were randomized to the 3 arms. At week 8, the electro-acupuncture group had clinically important and significant reduction in joint pain severity (-2.2 vs -0.2, P = .0004) and pain-related interference (-2.0 vs 0.2, P = .0006) compared with the WLC. The electro-acupuncture group also had significant improvement in fatigue as measured by the Brief Fatigue Inventory (-2.1 vs 0.4, P = .0016) and sleep as measured by the Pittsburg Sleep Quality Index (-2.2 vs 0.3, P = .021) compared with the WLC. The improvement in pain, fatigue, and sleep appeared to be maintained at 4 weeks following the last acupuncture treatment. The magnitude of effects on these symptoms was similar in the electro-acupuncture and sham acupuncture groups. Discussion: Electro-acupuncture significantly improved AI-related arthralgia and comorbid fatigue and sleep problems over usual care with clinically important and durable changes. Our preliminary findings suggest that electro-acupuncture may have the potential to address a cluster of symptoms in breast cancer survivors receiving AIs. The similar treatment effects between the electro and sham groups suggest that a large component of acupuncture effect is mediated through the process of acupuncture delivery rather than the specificity of needling techniques.
   Abstract 53: Association of Physical Activity and Telomere Length in Breast Cancer SurvivorsBackground: Cellular telomere length (TL) is a biomarker of accumulated cellular damage and human aging. Evidence suggests that TL may be affected by a host of psychosocial and lifestyle factors, including physical activity (PA). This is the first study to evaluate the relationship between PA and TL in breast cancer survivors. Methods: A cross-sectional sample of 392 postmenopausal women with stage 0-III breast cancer at an outpatient breast oncology clinic of a large university hospital completed questionnaires and provided a blood sample. TL was determined using mean terminal restriction fragment length and isolated from peripheral blood mononuclear cells. PA was dichotomized into 2 groups (none vs moderate to vigorous) using the International Physical Activity Questionnaire. Multivariate logistic and linear regression analyses were performed to identify factors associated with TL and PA. Results: Among participants, 66 (17%) did not participate in any PA. In the adjusted model, older women (>65 years) has significantly shorter TL (coefficient = -0.27; P = .02), while women who participated in moderate to vigorous PA has significantly longer TL (coefficient = 0.22; P = .03). Obese women (body mass index 30 kg/m(2)) were 64% less likely to engage in PA (adjusted odds ratio [AOR] = 0.44; P = .05), and women experiencing higher levels of fatigue were 15% less likely (AOR = 0.85; P = .05). Women with a college (AOR = 2.37; P = .03) or graduate education (AOR = 2.37; P = .001) were both significantly more likely to engage in PA. Conclusion: Lack of PA is associated with shortened TL, warranting prospective investigation of the potential role of PA on cellular aging in breast cancer survivors. Future research is needed to address the barriers to PA in women with breast cancer, especially for those who are obese and with lower education.
   Abstract 20: Tumor Resistance, Immuno-Enhancement and Life Span Increase Mediated by an Extract of North American GinsengBackground: Cells belonging to the innate immune system, that is, natural killer (NK) cells, act as the first line of defense against developing neoplasms. We previously showed both tumor reduction and immune-enhancement in leukemia cell-injected DBA/2 mice given a proprietary extract of North American ginseng (CVT-E002) daily, via the diet. The extract is in the marketplace as Cold FX. Methods: Elderly, female C3H/HeN mice were used because they are prone to the development of assorted cancers, predominant among which are breast cancers. A homogenized mixture of powdered standard mouse chow containing CVT-E002 (80 mg/6 g chow/day/mouse), was fed for 11 months, from age 22 months, after which half the mice were euthanized (age 33 months). The chow of parallel control mice contained no CVT-E002. The spleens (SPL) and bone marrow (BM) were removed and assayed for their content of NK cells and lymphocytes. The remaining half of the CVT-E002-fed mice were placed on the control diet at 11 months and left to assess life span. Results: In mice consuming CVT-E002 from 22 to 33 months, the absolute numbers of NK cells in their SPL and BM were elevated over control (P < .0004 and P < .0001, respectively) as were the absolute numbers of lymphocytes (non-NK) in both organs (P < .0001 and P < .0001, respectively). No CVT-E002-consuming mouse had any tumors at whole-body autopsy when euthanized (age 33 months) versus 100% bearing tumors (47% breast cancers) in control-diet mice. The remaining half (above) of the CVT-E002-consuming mice lived on until they were intentionally euthanized just over 4 years of ageall still tumor free. Conclusion: The results indicate (1) a profound effect of CVT-E002 in tumor resistance, (2) a significant increase in the numbers of immune cells, and (3) a strikingly long life (>4 years) in these inbred mice, equivalent to 126 human years.
   Abstract 30: Pomegranate Extracts Impact Androgen Biosynthesis Pathways In Vitro and In VivoBackground: Residual tissue androgens are consistently detected within prostate tumors from chemically castrated patients and are thought to facilitate androgen receptor (AR)-mediated disease progression to castration-resistant prostate cancer (CRPC). The source of these steroids has been attributed to the conversion of adrenally sourced precursor substrates. Testosterone and dihydrotestosterone (DHT) can be produced through 3 biosynthesis pathways: (4), (5), and backdoor pathways. Pomegranate extracts have been demonstrated to have anticancer activity, particularly in CRPC. This study examines the effects of pomegranate extracts (POMELLA) on steroid biosynthesis using PCa cell lines (22RV1 and LNCaP) in vitro as well as the conditional PTEN knockout prostate cancer model in vivo. Methods: Steroids produced by 22RV1 and LNCaP cells (treated by POMELLA) for 48 hours at 2, 4, 5, 8, 12 mu g/mL, respectively, as well as mouse serum taken after treatment with PFEs in drinking water (0.17 g/L of POMELLA in 1% sucrose solution for 20 weeks) or control (1% sucrose water) were analyzed via UPLC/MS/MS. Results: In vitro experiments showed that POMELLA extracts significantly reduced testosterone, DHT, dehydroepiandrosterone (DHEA), androstenedione, androsterone, and pregnenolone production. Testosterone and DHT were significantly lower in cells treated with pomegranate extracts compared with controls, at 5 to 12 mu g/mL concentrations (n = 6, P < .05). Our in vivo study also confirmed that testosterone and DHEA in the serum of the POMELLA-treated mice were significantly lower than control mice (n = 7, P < .05). Conclusion: Pomegranate extracts attenuate testosterone and DHT in vitro and lower serum androgen levels in vivo, in a conditional PTEN knockout prostate cancer model.
   Abstract 109: Drug-Micronutrient Interactions in Cancer: The Case of Vitamin DBackground: The chemopreventive and therapeutic effects of vitamin D3 are exerted through 1,25-(OH)(2)D3, the dihydroxy metabolite of vitamin D3. Inactivation of 1,25-(OH)(2)D3 by cytochrome P450 3A (CYP3A) enzymes can be an important determinant of its serum and tissue levels. The purpose of the present study was to assess the potential of various medications, which are commonly used in the treatment regimens of patients with cancer (eg, abiraterone, ketoconazole, tamoxifen, taxanes) and as premedications (eg, dexamethasone, prednisone) to chemotherapy, on biotransformation of 1,25-(OH)(2)D3 in human and mouse liver microsomes. Methods: Adult CD-1 mice were treated with vehicle (50% ethanol), dexamethasone (80 mg/kg/day) or prednisone (80 mg/kg/d) for 3 consecutive days by intraperitoneal injection. Mouse livers were used to prepare microsomes by differential ultracentrifugation. In vitro reaction mixtures contained potassium phosphate buffer, mouse or human hepatic microsomal protein (XenoTech LLC) or human recombinant CYP3A4 supersomes, NADPH, and a fixed concentration of 20 mu M 1,25-(OH)(2)D3. Reactions were initiated with NADPH after initial preincubation of microsomes with 1,25-(OH)(2)D3 and various concentrations of abiraterone (0.2-100 mu M), ketoconazole (0.05-10 mu M), tamoxifen (1-100 mu M), and docetaxel (0.1-1.24 mu M) at 37 degrees C. Formation of hydroxylated metabolites of 1,25-(OH)(2)D3 were analyzed by liquid chromatography-mass spectrometry method. Results: The formation of hydroxy metabolites was significantly stimulated in hepatic microsomes from mice treated with dexamethasone compared with vehicle- and prednisone-treated group. Co-incubation of 1,25-(OH)(2)D3 with various drugs led to up to similar to 85% to 99% inhibition of formation of hydroxylated metabolites of 1,25-(OH)(2)D3 and therefore reduced inactivation of active vitamin D3. The IC50 values (GraphPad PrismTM v4.0 software) for individual metabolites of 1,25-(OH)(2)D3 ranged from 0.012 to 2.20 mu M in human liver microsomes. Conclusions: In summary, our results suggest that premedications and co-medications administered in cancer patients can either exacerbate or inhibit the CYP3A-mediated inactivation of active vitamin D3 leading to altered vitamin D homeostasis.
   Abstract 71: Disturbed Sleep in Cancer Survivors: Is There a Place for Mindfulness-Based Interventions?Background: After completing treatment, cancer survivors often suffer from a multitude of physical and mental health impairments, resulting in compromised quality of life. This exploratory study investigated whether 2 mind-body interventions, Mind-Body Bridging (MBB) and Mindfulness Meditation (MM), could improve posttreatment cancer survivors' self-reported sleep disturbance and comorbid symptoms, as compared to Sleep Hygiene Education (SHE) as an active control. Methods: This randomized controlled trial examined 57 cancer survivors with clinically significant self-reported sleep disturbance, randomly assigned to receive MBB, MM, or SHE. All interventions were conducted in three sessions, once per week. Patient-reported outcomes were assessed via the Medical Outcomes Study Sleep Scale and other indicators of psychosocial functioning relevant to quality of life, stress, depression, mindfulness, self-compassion, and well-being. Results: Mixed effects model analysis revealed that mean sleep disturbance symptoms in the MBB and MM groups were lower than in the SHE group, indicating that both mind-body interventions improved sleep. Also, compared with the SHE group, the MBB group showed reductions in self-reported depression symptoms and improvements in overall levels of mindfulness, self- compassion, and well-being at postintervention. Conclusions: This study provides preliminary evidence that brief sleep-focused MBB and MM are promising interventions for sleep disturbance in cancer survivors. Integrating MBB or MM into posttreatment supportive plans should enhance care of cancer survivors with sleep disturbance. Because MBB produced additional secondary benefits, MBB may serve as a promising multipurpose intervention for posttreatment cancer survivors suffering from sleep disturbance and other comorbid symptoms. Management of sleep problems in survivors is a high priority issue that demands more attention in cancer survivorship.
   Abstract 133: EEG Imaging and Neuromodulation of Acute Pain in Head and Neck Cancer Patients Undergoing RadiotherapyBackground: We investigated the effectiveness of a brain-computer interface (LORETA neurofeedback) to manage acute onset pain and examine the neurophysiological mechanisms and localization of pain as a result of head and neck radiation. Methods: Patients undergoing head and neck radiation (n = 4 of 10 to date; male; right-handed; mean age = 53.5 years) completed baseline questionnaires and underwent a baseline electroencephalography (EEG). A second EEG was done on the first written prescription for pain medications, but before the medications were started, and a final EEG was performed at the conclusion of radiotherapy. Patients had a total of 6 LORETA neurofeedback sessions after their pain became at least a 4 on a 0 to 10 scale for 3 consecutive days. Patients were asked to rate their pain on a scale of 0 to 10 before and after each neurofeedback session. The Brief Pain Inventory (BPI), the Multidimensional Pain Inventory (MPI), and the MD Anderson Symptom Inventory for Head and Neck Cancer (MDASI-HN) were completed at baseline and end of radiotherapy. Results: LORETA results demonstrated that (1) regions of the pain network increase in beta (13-21 Hz) activity relative to baseline (primary somatosensory cortex, dorsolateral prefrontal cortex), and other regions not associated with the pain network also increased in activity (precuneus). During LORETA neurofeedback sessions, patients could reduce activity in the pain network relative to their painful EEG map activity. Pain ratings also decreased from pre- to post-session (mean decrease = 2.14). Self-report data and the association between self-report and brain activity will be presented with the complete data set (n = 10). Conclusions: We were able to capture brain activity during acute pain onset and show that patients can change that brain activity to a less painful state with LORETA neurofeedback. Identification of these regions and successful EEG neurofeedback training will allow a targeted approach to acute pain management that is independent of medications.
   Abstract 136: Baseline Depression Levels Moderate the Effectiveness of Expressive Writing for Patients With Renal Cell CarcinomaBackground: Expressive writing (EW) has been demonstrated to be an effective approach to improve quality of life in cancer patients. We previously reported that EW reduced intrusive thoughts and improved cancer-related symptoms (MD Anderson Symptom Inventory [MDASI]) in renal cell carcinoma (RCC) patients. Here we examined if depressive symptoms at study entry moderated the effectiveness of the EW program. Methods: Patients (n = 277) with RCC scheduled to receive surgical or systemic treatment were randomly assigned to write about either their deepest thoughts and feelings about their cancer (EW) or neutral topics (NW) on 4 separate occasions over 10 days. Patients completed measures of depressive symptoms (Center for Epidemiologic Studies-Depression [CES-D]), MDASI, fatigue (Brief Fatigue Inventory [BFI]), and sleep disturbances (Pittsburgh Sleep Quality Index [PSQI]) at baseline, and 1, 4, and 10 months after the writing sessions. Results: The mean age of participants was 58 years, and 41% were female. Participants had been diagnosed with stage I (38%), stage II (14%), stage III (18%), or stage IV (28%). After controlling for baseline levels of the outcome variables, multilevel modeling analyses revealed that participants in the EW group who had elevated depressive symptoms at baseline had worse outcomes than those in the NW group with elevated depressive symptoms at baseline. Specifically, at 1 month postintervention, participants in the EW group reported more cancer-related symptoms (MADSI; P < .01), sleep disturbances (PSQI; P < .01), and fatigue (BFI; P < .01) compared with those in the NW group. There were no group differences for those low in baseline depressive scores. Conclusions: These findings suggest that patient baseline characteristics may moderate the effectiveness of an EW program. Those with elevated depressive symptoms at study entry do not appear to benefit from an EW program and, in fact, EW may result in worse outcomes. Clinician-facilitated treatments providing more intense supportive care may be need to improve quality of life outcomes in patients with depressive symptoms.
   Abstract 127: Acupuncture for Dysphagia After Chemoradiation Therapy in Head And Neck Cancer: A Pilot Randomized Sham-Controlled TrialBackground: Dysphagia is a common side effect following chemoradiation therapy (CRT) in patients with head and neck cancer (HNC). The purpose of this pilot trial was to assess the feasibility of recruiting HNC patients and to collect preliminary data on the efficacy and safety of acupuncture on dysphagia-related quality-of-life (QOL). Methods: Patients were eligible if diagnosed with stage III-IV HNC, without evidence of distance metastasis, receiving curative-intent CRT. Patients were randomized to 12 sessions of either active or sham acupuncture, once every 2 weeks, over 24 weeks from during CRT to 20-week post-CRT. All study personnel and the patients were blinded; the treating acupuncturists were not. MD Anderson Dysphagia Inventory (MDADI) and other questionnaires were measured at baseline (end of CRT), end of acupuncture, and at 6 months follow-up (12-month post-CRT). Data were analyzed by repeated-measures analysis of variance (ANOVA) adjusting for baseline. Results: Accrual was completed in December 2011. Among 42 patients enrolled, 35 (83%) received at least 8 sessions of acupuncture, and 28 (67%) received all 12. Six patients withdrew because of time constraints. No serious side effects were observed. The mean MDADI total scores improved from baseline in both treatment arms (64.5 [SE +/- 2.4] vs 71.4 [SE +/- 3.1], P = .048; 64.5 [SE +/- 2.4] vs 77.8 [SE +/- 3.0], P < .001); the difference in improvement was not significant (P = .12). The median feeding tube duration did not differ between active and sham treatments (n = 39, median 125 days vs 147 days, P = .93). Conclusions: Acupuncture is a safe and feasible treatment for HNC patients. In the pilot trial, improvements in QOL parameters from end of CRT to the time points examined were observed but they did not differ between the 2 arms. Efficacy of acupuncture to improve swallowing-related QOL in HNC patients may require more frequent or longer duration of treatment.
C1 [Balneaves, Lynda G.] Univ British Columbia, Sch Nursing, Vancouver, BC V6T 2B5, Canada.
   [Lee, Richard T.] Univ Texas MD Anderson Canc Ctr, Dept Gen Med, Houston, TX 77030 USA.
   [Guns, Emma S. Tomlinson] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6T 2B5, Canada.
   [Zick, Suzanna M.] Univ Michigan, Dept Family Med, Ann Arbor, MI 48109 USA.
   [Zick, Suzanna M.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Bauer-Wu, Susan] Univ Virginia, Sch Nursing, Charlottesville, VA 22903 USA.
   [Greenlee, Heather] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
   [Greenlee, Heather] Herbert Irving Comprehens Canc Ctr, New York, NY USA.
C3 University of British Columbia; University of Texas System; UTMD
   Anderson Cancer Center; University of British Columbia; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Virginia; Columbia University
RP Balneaves, LG (corresponding author), Univ British Columbia, Sch Nursing, T201-2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.
EM lynda.balneaves@nursing.ubc.ca
RI Balneaves, Lynda/AAG-9383-2021; Lee, Richard/AAS-1416-2021
OI Balneaves, Lynda/0000-0002-6535-2096; Lee, Richard/0000-0001-9916-6155
FU National Institutes of Health's National Cancer Institute; National
   Institutes of Health's National Center for Complementary and Alternative
   Medicine [R13CA183288]; Canadian Institutes for Health Research; Lotte
   and John Hecht Memorial Foundation; Weil Foundation
FX The conference received support from the National Institutes of Health's
   National Cancer Institute and National Center for Complementary and
   Alternative Medicine (R13CA183288), the Canadian Institutes for Health
   Research, the Lotte and John Hecht Memorial Foundation, and the Weil
   Foundation.
CR Deng GE, 2013, CHEST, V143, pE420, DOI 10.1378/chest.12-2364
NR 1
TC 3
Z9 4
U1 7
U2 327
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JAN
PY 2014
VL 13
IS 1
BP 5
EP 11
DI 10.1177/1534735413517743
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA AA0GQ
UT WOS:000330774000001
PM 24420529
OA gold
DA 2026-01-16
ER

PT J
AU Piedalue, KAL
   Reed, EN
   Oberoi, D
   Carlson, LE
   Landmann, J
AF Piedalue, Katherine-Ann L.
   Reed, Erica N.
   Oberoi, Devesh
   Carlson, Linda E.
   Landmann, Jessa
TI GROUP VERSUS INDIVIDUAL ACUPUNCTURE FOR THE TREATMENT OF CANCER PAIN
SO PSYCHOSOMATIC MEDICINE
LA English
DT Meeting Abstract
CT 77th Annual Scientific Meeting of the American-Psychosomatic-Society on
   Body to Mind
CY MAR 06-09, 2019
CL Vancouver, CANADA
SP Amer Psychosomat Soc
C1 [Piedalue, Katherine-Ann L.] Univ Calgary, Psychosocial Oncol, Calgary, AB, Canada.
   [Reed, Erica N.] Univ Calgary, Cummings Sch Med, Calgary, AB, Canada.
   [Oberoi, Devesh; Carlson, Linda E.; Landmann, Jessa] Univ Calgary, Cummings Sch Med, Psychosocial Oncol, Naturopath Med, Calgary, AB, Canada.
C3 University of Calgary; University of Calgary; University of Calgary
RI Carlson, Linda/AEN-5702-2022
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY
PY 2019
VL 81
IS 4
MA 1350
BP A37
EP A37
PG 1
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Psychiatry; Psychology
GA HX7CG
UT WOS:000467560700105
DA 2026-01-16
ER

PT J
AU Martini, RS
   Brown, T
   Singh, V
   Woodbury, A
AF Martini, Reema Sabeeha
   Brown, Terrell
   Singh, Vinita
   Woodbury, Anna
TI Integrative Approaches for Cancer Pain Management
SO CURRENT ONCOLOGY REPORTS
LA English
DT Review
DE Integrative; Complementary; Alternative; Acupuncture; Yoga; Cancer pain
ID QUALITY-OF-LIFE; INDUCED PERIPHERAL NEUROPATHY; BREAST-CANCER;
   MINDFULNESS MEDITATION; COLORECTAL-CANCER; METASTATIC-CANCER;
   RANDOMIZED-TRIAL; BONE METASTASES; DOUBLE-BLIND; VITAMIN-C
AB Purpose of ReviewThe goal of this review is to summarize updates to the broad array of complementary therapies available for cancer pain. This paper will serve as a reference for clinicians managing pain in cancer patients.Recent FindingsPatients are embracing integrative therapies in growing numbers; clinicians must be prepared to incorporate these therapies into patients' existing treatment regimens. This requires knowledge regarding risks, benefits, and potential interactions with existing cancer therapies.SummaryIntegrative cancer pain management strategies have shown promise, with several proven effective for the management of cancer pain. Energy therapies, including acupuncture, and biologicals and nutraceuticals including overall diet and vitamin D, have the highest level of evidence for efficacy. The remaining therapies discussed in this chapter may be beneficial for patients on a case-by-case basis; risks and benefits of each individual therapy as described in the text must be further assessed in future rigorous trials to further clarify the role of these complementary therapies in cancer pain management.
C1 [Martini, Reema Sabeeha; Singh, Vinita; Woodbury, Anna] Emory Univ, Dept Anesthesiol, Sch Med, Atlanta, GA 30322 USA.
   [Martini, Reema Sabeeha] Emory Univ, Laney Grad Sch, Atlanta, GA 30322 USA.
   [Brown, Terrell] Morehouse Sch Med, Atlanta, GA USA.
   [Woodbury, Anna] Atlanta Vet Affairs Healthcare Syst, Atlanta, GA USA.
C3 Emory University; Emory University; Morehouse School of Medicine
RP Martini, RS (corresponding author), Emory Univ, Dept Anesthesiol, Sch Med, Atlanta, GA 30322 USA.; Martini, RS (corresponding author), Emory Univ, Laney Grad Sch, Atlanta, GA 30322 USA.
EM reema.martini@emory.edu
RI Woodbury, Anna/HJZ-3635-2023; Singh, Vinita/AAF-4262-2019
OI Woodbury, Anna/0000-0003-0644-6049; Martini, Reema/0009-0009-1898-1496
FU Georgia Clinical and Translational Science Alliance
FX No Statement Available
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NR 153
TC 4
Z9 5
U1 2
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3790
EI 1534-6269
J9 CURR ONCOL REP
JI Curr. Oncol. Rep.
PD JUN
PY 2024
VL 26
IS 6
BP 691
EP 705
DI 10.1007/s11912-024-01536-3
EA APR 2024
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA TY4P2
UT WOS:001209521600001
PM 38683254
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Wu, HWV
   Li, XT
   Li, QS
   Baser, RE
   Panageas, KS
   Chimonas, S
   Tap, WD
   Bender, JG
   Moskowitz, CS
   Mao, JJ
AF Wu, Han-Wei V.
   Li, Xiaotong
   Li, Qing S.
   Baser, Raymond E.
   Panageas, Katherine S.
   Chimonas, Susan
   Tap, William D.
   Glade Bender, Julia
   Moskowitz, Chaya S.
   Mao, Jun J.
TI Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult
   Patients with Advanced Cancer: Subgroup Analysis of a Randomized
   Clinical Trial
SO JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
LA English
DT Article; Early Access
DE pain management; health-related quality of life; supportive care;
   quality of life
ID INTEGRATIVE MEDICINE; ONCOLOGY SOCIETY; ELECTROACUPUNCTURE; MANAGEMENT;
   THERAPY; MECHANISMS; SYMPTOMS; SARCOMA; TOUCH
AB Purpose: Pain management remains challenging for adolescent and young adult (AYA) cancer patients. Acupuncture and massage have been recommended for cancer-related pain management, but no prospective trials have been conducted in AYA patients. We explored the effects of acupuncture and massage on pain in AYAs. Methods: This subgroup analysis focused on AYA patients (aged 18-39 years) enrolled in a randomized controlled trial comparing acupuncture and massage for pain management in advanced cancer. Interventions were delivered weekly for 10 weeks, followed by monthly booster treatments through week 26. The primary outcome was the worst pain score from the Brief Pain Inventory, analyzed using a linear mixed-effects model. Results: Thirty participants met eligibility criteria (13 acupuncture; 17 massage), with a mean age of 31.1 years (standard deviation, 5.8); 57% were female; 67% were White; and 53% had solid tumors. Both groups experienced reduced pain over time. Relative to baseline, patients receiving acupuncture had a mean change of -1.26 points (95% confidence interval [CI], -2.54 to 0.01) at 10 weeks and a mean change of -1.46 points (95% CI, -2.78 to -0.14) at 26 weeks. Patients receiving massage experienced a mean change of -2.81 points (95% CI, -3.92 to -1.70) at week 10 and a mean change of -3.79 points (95% CI, -4.85 to -2.73) at week 26. Conclusion: AYA patients with advanced cancer who received either acupuncture or massage experienced clinically meaningful and sustained reductions in pain. These findings provide a promising foundation for future trials aimed at evaluating integrative pain management strategies in AYAs.
C1 [Wu, Han-Wei V.; Glade Bender, Julia] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY USA.
   [Li, Xiaotong; Li, Qing S.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,Room 456, New York, NY 10065 USA.
   [Baser, Raymond E.; Panageas, Katherine S.; Chimonas, Susan; Moskowitz, Chaya S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.
   [Tap, William D.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering
   Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,Room 456, New York, NY 10065 USA.
EM maoj@mskcc.org
RI Li, Xiaotong/HTN-2157-2023
OI Wu, Han-Wei/0009-0002-2834-8407
FU NIH/National Cancer Institute (NCI) Cancer Center [P30 CA008748]; NCI
   [T32 CA275764]; PCORI award [SMPAI-2018C2-12883]; Memorial Sloan
   Kettering Cancer Center
FX This work was supported, in part, by the NIH/National Cancer Institute
   (NCI) Cancer Center grant to Memorial Sloan Kettering Cancer Center (P30
   CA008748), NCI T32 CA275764 (H.V.W.), and PCORI award
   (SMPAI-2018C2-12883 to J.J.M. through Memorial Sloan Kettering Cancer
   Center)
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NR 59
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2156-5333
EI 2156-535X
J9 J ADOLESC YOUNG ADUL
JI J. Adolesc. Young Adult Oncol.
PD 2025 AUG 13
PY 2025
DI 10.1177/21565333251368891
EA AUG 2025
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 6DR2H
UT WOS:001550878700001
PM 40803676
DA 2026-01-16
ER

PT J
AU Jin, H
   Liang, J
   Zhang, SQ
   Ma, S
   Qin, HY
   Zhang, DX
   Pang, XY
   Zhang, M
AF Jin, Hong
   Liang, Ji
   Zhang, Siqi
   Ma, Shuai
   Qin, Hongyu
   Zhang, Dongxu
   Pang, Xueying
   Zhang, Miao
TI External treatment of traditional Chinese medicine for cancer pain: A
   systematic review and network meta-analysis
SO MEDICINE
LA English
DT Article
DE analgesic; cancer pain; efficacy; External treatment of traditional
   Chinese medicine; network meta-analysis
ID INTERVENTIONS; ANALGESICS; MECHANISMS; GUIDELINES
AB Background:Cancer pain is one of the most intolerable and frightening symptoms of cancer patients. However, the clinical effect of the three-step analgesic ladder method (TSAL) is not satisfactory. The combination of external treatment of traditional Chinese medicine (TCM) can improve the clinical effect.Objective:This study used network meta-analysis to compare the effects of different external treatment methods of TCM combined with TSAL on cancer pain.Methods:Databases searched by our team included Google Scholar, Web of Science, Scopus, Embase, PubMed, and Cochrane Library. Randomized controlled trials related to the external treatment of TCM combined with TSAL for cancer pain were screened from the establishment of the database till now. The above literature extracted clinical efficacy, NRS score, KPS score, analgesic onset time, and duration as the main results after the screening. The 95% confidence interval (95% CI) of OR value and SMD value was used as the effect index to compare the difference in efficacy of different interventions, and the ranking was conducted. STATA 17.0 software was used for the statistical analysis of the above data.Results:A total of 78 studies were included, including 8 interventions and 5742 participants. Based on ranking probability, the clinical effective rate of manual acupuncture combined with TSAL was the best when the intervention time was set at 4 weeks [OR = 5.42, 95% CI (1.99,14.81)], and the improvement effect on KPS score was also the best [SMD = 0.97, 95% CI (0.61, 1.33)]. Acupoint external application was the best intervention in reducing NRS score [SMD = -1.14, 95% CI (-1.90, -0.93)]. Acupoint moxibustion combined with TSAL was considered to be the most effective intervention to prolong the duration of analgesia [SMD = 1.69, 95% CI (0.84, 2.54)] and shortening the onset time of analgesia [SMD = -3.00, 95% CI (-4.54, -1.47)].Conclusions:TSAL combined with manual acupuncture is the best in terms of clinical efficacy and improvement of patients' functional activity status. With the extension of treatment time, the intervention of this kind of treatment on the clinical effect is more pronounced. Acupoint external application also has a unique advantage in reducing the pain level of patients. From the point of view of analgesic duration and duration of analgesia, combined acupoint moxibustion has the best effect.
C1 [Jin, Hong; Liang, Ji; Zhang, Siqi; Ma, Shuai; Qin, Hongyu; Zhang, Dongxu] Heilongjiang Univ Chinese Med, Harbin, Peoples R China.
   [Pang, Xueying] Heilongjiang Univ Chinese Med, Oncol Dept, Affiliated Hosp 1, Harbin, Peoples R China.
   [Zhang, Miao] Heilongjiang Univ Chinese Med, Affiliated Hosp 2, Acupuncture & Moxibust Consulting Room 10, 411 Gogol St, Harbin 150001, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; Heilongjiang University of Chinese Medicine
RP Zhang, M (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 2, Acupuncture & Moxibust Consulting Room 10, 411 Gogol St, Harbin 150001, Peoples R China.
EM jinhong517kh@163.com; hljucm_lj@126.com; 13845088833@139.com;
   m18245119455@163.com; qinhongyu0503@163.com; 13845088833@139.com;
   pangxueying11@163.com; 13845088833@139.com
FU High-level Key Disciplines of Traditional Chinese Medicine [14061230010]
FX The research of our article was funded by High-level Key Disciplines of
   Traditional Chinese Medicine (no. 14061230010).
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   Zhang HB., 2011, Guangzhou Univ Tradit Chin Med
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   Zhao WS., 2017, P 3 ANN C WORLD ZHON, P325
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NR 101
TC 2
Z9 3
U1 4
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 23
PY 2024
VL 103
IS 8
AR e37024
DI 10.1097/MD.0000000000037024
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JQ5G0
UT WOS:001174637500046
PM 38394488
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, J
   Wahner-Roedler, DL
   Zhou, X
   Johnson, LA
   Do, A
   Pachman, DR
   Chon, TY
   Salinas, M
   Millstine, D
   Bauer, BA
AF Yang, Juan
   Wahner-Roedler, Dietlind L.
   Zhou, Xuan
   Johnson, Lesley A.
   Do, Alex
   Pachman, Deirdre R.
   Chon, Tony Y.
   Salinas, Manisha
   Millstine, Denise
   Bauer, Brent A.
TI Acupuncture for palliative cancer pain management: systematic review
SO BMJ SUPPORTIVE & PALLIATIVE CARE
LA English
DT Review
DE cancer; pain; supportive care
ID SYMPTOM MANAGEMENT; OF-LIFE; CARE; STATISTICS; PATIENT; WOMEN
AB Background Pain is one of the most common and problematic symptoms encountered by patients with cancer. Due to the multifactorial aetiology, pain management of these patients frequently requires multidisciplinary interventions including conventional support and specialty palliative care. Acupuncture has been identified as a possible adjunctive therapy for symptom management in cancer pain, and there is currently no systematic review focused solely on the evidence of acupuncture on cancer pain in palliative care. Objective To critically analyse currently available publications regarding the use of acupuncture for pain management among patients with cancer in palliative care settings. Methods Multiple academic databases were searched from inception to 29 October 2020. Randomised controlled trials involving acupuncture in palliative care for treatment of cancer-related pain were synthesised. Data were extracted by two independent reviewers, and methodological quality of each included study was assessed using the Oxford Centre for Evidence-Based Medicine (OCEBM) 2011 Levels of Evidence. Results Five studies (n=189) were included in this systematic review. Results indicated a favourable effect of acupuncture on pain relief in palliative care for patients with cancer. According to OCEBM 2011 Levels of Evidence, they were level 2 in one case (20%), level 3 in two cases (40%) and level 4 in the remaining (40%). Low-level evidence adversely affects the reliability of findings. Conclusions Acupuncture may be an effective and safe treatment associated with pain reduction in the palliative care of patients with cancer. Further high-quality, adequately powered studies are needed in the future.
C1 [Yang, Juan; Wahner-Roedler, Dietlind L.; Do, Alex; Chon, Tony Y.; Bauer, Brent A.] Mayo Clin, Div Gen Internal Med, Rochester, MN 55905 USA.
   [Zhou, Xuan] Jinan Univ, Sch Tradit Chinese Med, Formula Pattern Res Ctr, Guangzhou, Peoples R China.
   [Johnson, Lesley A.; Millstine, Denise] Mayo Clin, Dept Womens Hlth Internal Med, Scottsdale, AZ USA.
   [Pachman, Deirdre R.] Mayo Clin, Ctr Palliat Med, Rochester, MN USA.
   [Salinas, Manisha] Mayo Clin, Div Family Med, Jacksonville, FL 32224 USA.
C3 Mayo Clinic; Jinan University; Mayo Clinic; Mayo Clinic Phoenix; Mayo
   Clinic; Mayo Clinic
RP Bauer, BA (corresponding author), Mayo Clin, Div Gen Internal Med, Rochester, MN 55905 USA.
EM Bauer.Brent@mayo.edu
RI ZHOU, xuan/O-2861-2016
FU HEAD Foundation, Singapore
FX This study was funded by The HEAD Foundation, Singapore.
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NR 47
TC 56
Z9 70
U1 0
U2 20
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2045-435X
EI 2045-4368
J9 BMJ SUPPORT PALLIAT
JI BMJ Support. Palliat. Care
PD SEP
PY 2021
VL 11
IS 3
BP 264
EP 270
DI 10.1136/bmjspcare-2020-002638
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA UO4GR
UT WOS:000694654100004
PM 33441387
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zhao, JC
   Li, JH
   Zhou, JF
   Li, M
AF Zhao, Junchao
   Li, Jiahui
   Zhou, Jinfeng
   Li, Ming
TI Comment on: "Acupuncture Treatment for Liver Cancer Pain: A
   Meta-Analysis"
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Letter
C1 [Zhao, Junchao; Li, Jiahui; Zhou, Jinfeng] Haiyan Hosp Tradit Chinese Med, Jiaxing, Peoples R China.
   [Li, Ming] Cent Hosp Haining, Jiaxing, Peoples R China.
RP Li, M (corresponding author), Cent Hosp Haining, Jiaxing, Peoples R China.
EM liminghaining@126.com
FU This work was funded by Administration of Traditional Chinese Medicine
   of Zhejiang Province (2024ZL173). [2024ZL173]; Administration of
   Traditional Chinese Medicine of Zhejiang Province
FX The authors have nothing to report. This work was funded by
   Administration of Traditional Chinese Medicine of Zhejiang Province
   (2024ZL173).
CR Llovet Josep M, 2021, Nat Rev Dis Primers, V7, P6, DOI [10.1038/s41572-021-00245-6, 10.1038/s41572-021-00245-6, 10.1038/s41572-020-00240-3]
   He Y, 2024, J SURG ONCOL, V130, P83, DOI 10.1002/jso.27691
NR 2
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD APR
PY 2025
VL 131
IS 5
BP 765
EP 766
DI 10.1002/jso.28035
EA DEC 2024
PG 2
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 3FU6J
UT WOS:001368905600001
PM 39623460
OA Bronze
DA 2026-01-16
ER

PT J
AU Chen, ML
   Zhao, H
   He, L
AF Chen, Menglin
   Zhao, Hua
   He, Ling
TI Comment On: "Acupuncture Treatment for Liver Cancer Pain: A
   Meta-Analysis"
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Letter
C1 [Chen, Menglin; He, Ling] Jiangxi Univ Chinese Med, Sch Clin Med, Nanchang, Peoples R China.
   [Chen, Menglin; He, Ling] Jiangxi Univ Chinese Med, Affiliated Hosp, Gastroenterol Div, Nanchang, Peoples R China.
   [Zhao, Hua] Zhejiang Chinese Med Univ, Sch Basic Med, Hangzhou, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; Zhejiang Chinese Medical University
RP He, L (corresponding author), Jiangxi Univ Chinese Med, Sch Clin Med, Nanchang, Peoples R China.; He, L (corresponding author), Jiangxi Univ Chinese Med, Affiliated Hosp, Gastroenterol Div, Nanchang, Peoples R China.
EM heling118@126.com
OI Zhao, Hua/0009-0001-5770-5277
CR Cai W., 2017, J CLIN ACUPUNCTURE M, V33, P76
   He Y, 2024, J SURG ONCOL, V130, P83, DOI 10.1002/jso.27691
   Yang X., 2024, LIAONING J TRADITION, V51, P156
NR 3
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD FEB
PY 2025
VL 131
IS 2
BP 106
EP 107
DI 10.1002/jso.27918
EA SEP 2024
PG 2
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 1ZZ2P
UT WOS:001316690500001
PM 39300895
DA 2026-01-16
ER

PT J
AU Wang, PM
   Hsu, CW
   Liu, CT
   Lai, TY
   Tzeng, FL
   Huang, CF
AF Wang, Pei-Ming
   Hsu, Ching-Wen
   Liu, Chun-Ting
   Lai, Ting-Yu
   Tzeng, Fe-Ling
   Huang, Chih-Fang
TI Effect of acupressure on constipation in patients with advanced cancer
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Advanced cancer; Constipation; Acupressure; Complementary medicine
ID OPIOID-INDUCED CONSTIPATION; SYMPTOM MANAGEMENT; SELF-ACUPRESSURE;
   ACUPUNCTURE; EFFICACY; PAIN; THERAPIES; TRIALS
AB PurposeConstipation is a common and distressing symptom for patients with advanced cancer. Few reports have focused on the symptoms of constipation in patients with advanced cancer. The aim of this study was to investigate the effect of a short-term acupressure intervention on patients with advanced cancer.MethodsThis study used a non-randomized, pre-post study design to assess the effect of acupressure intervention. A total of 30 patients with advanced cancer were recruited from the hospice unit of a medical center in southern Taiwan. In addition to routine care, patients in the intervention group received an 8-min acupressure treatment daily for 3 consecutive days. Three acupoints were used in this study: Zhongwan (CV12), Guanyuan (CV4), and Tianshu (ST25). Analysis of covariance was used to compare the differences in symptoms of constipation between the two groups, adjusted for baseline values. Effect sizes were calculated using partial eta squared (eta(2)).ResultsSignificant improvements in symptoms of constipation (partial eta(2)=0.40, p<0.001 for straining during defecation; partial eta(2)=0.30, p=0.002 for hard stools; partial eta(2)=0.42, p<0.001 for sensation of incomplete evacuation; and partial eta(2)=0.29, p=0.002 for sensation of anorectal obstruction), Bristol stool form scale scores (partial eta(2)=0.40, p<0.001), comfort levels during defecation (partial eta(2)=0.82, p<0.001), and colonic motility (partial eta(2)=0.85, p<0.001) were observed in patients receiving acupressure intervention compared with the controls.ConclusionsFindings from this study indicated that short-term acupressure was effective in alleviating symptoms of constipation among patients with advanced cancer. Further, randomized controlled trials are warranted to confirm the results.
C1 [Wang, Pei-Ming; Huang, Chih-Fang] Kaohsiung Chang Gung Mem Hosp, Dept Family Med, 123 Dapi Rd, Kaohsiung 83301, Taiwan.
   [Hsu, Ching-Wen; Lai, Ting-Yu; Tzeng, Fe-Ling] Kaohsiung Chang Gung Mem Hosp, Dept Nursing, Kaohsiung, Taiwan.
   [Liu, Chun-Ting] Kaohsiung Chang Gung Mem Hosp, Dept Chinese Med, Kaohsiung, Taiwan.
   [Huang, Chih-Fang] Chung Hwa Univ Med Technol, Dept Long Term Care, Tainan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chung Hua University
RP Huang, CF (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Family Med, 123 Dapi Rd, Kaohsiung 83301, Taiwan.; Huang, CF (corresponding author), Chung Hwa Univ Med Technol, Dept Long Term Care, Tainan, Taiwan.
EM pauline.chifang@gmail.com
RI Lai, Ting-Yu/AAU-9223-2020; Liu, Chun-Ting/GWM-4693-2022
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NR 36
TC 18
Z9 22
U1 1
U2 34
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD SEP
PY 2019
VL 27
IS 9
BP 3473
EP 3478
DI 10.1007/s00520-019-4655-1
PG 6
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA IL9QJ
UT WOS:000477618900032
PM 30675666
DA 2026-01-16
ER

PT J
AU González-Escalada, JR
   Camba, A
   Casas, A
   Gascón, P
   Herruzo, I
   Núñez-Olarte, JM
   Ramos-Aguerri, A
   Trelis, J
   Torres, LM
AF Ramon Gonzalez-Escalada, Jose
   Camba, Alberto
   Casas, Ana
   Gascon, Pere
   Herruzo, Ismael
   Manuel Nunez-Olarte, Juan
   Ramos-Aguerri, Alfredo
   Trelis, Jordi
   Miguel Torres, Luis
TI Good clinical practice guide for control of oncological pain
SO MEDICINA PALIATIVA
LA Spanish
DT Article
DE Oncological pain; Breakthrough pain; Cancer; Opioids; Fentanyl
ID QUALITY-OF-CARE; CANCER PAIN; BREAKTHROUGH PAIN; INTRATHECAL ZICONOTIDE;
   ANALGESIC LADDER; RANDOMIZED-TRIAL; MANAGEMENT; MORPHINE; THERAPY;
   OPIOIDS
AB Patients with cancer often do not mention their pain as they are afraid that the doctor will be distracted towards this symptom instead of focusing on the treatment of their primary disease. However, should know that the treatment of their pain not only does it not interfere with their remedial therapy, but also contributes to it. It is usual, among patients, to be afraid that the advance of the disease may lead to situations of unsustainable suffering which may exceed all the medical possibilities, but it is our duty to help them to be aware that medicine offers a wide range of treatments to relieve their pain and prevent them suffering. This knowledge is essential to increase their confidence in the treatment and to improve the doctor-patient relationship.
   Faced with this challenge, the Spanish Society of Palliative Care, the Spanish Pain Society, the Spanish Medical Oncology Society, and the Spanish Society of Radiotherapeutic Oncology, have joined forces and created ALIADO (Alliance Against Oncological Pain), a multidisciplinary working group which was founded with the purpose of raising the awareness and involving all medical groups in the need to improve the quality of life of the patient with oncological pain.
   The first initiative of ALIADO in this direction, is the preparation of a good practice code for the treatment of oncological pain, which attempts to contribute to the advance of knowledge and treatment of these patients. (C) 2011 Sociedad Espanola de Cuidados Paliativos. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Miguel Torres, Luis] Hosp Univ Puerto del Mar, Serv Anestesia Reanimac & Tratamiento Dolor, Cadiz, Spain.
   [Trelis, Jordi] Hosp Badalona Germans Trias & Pujol, Inst Catalan Oncol, Serv Soporte Integral & Cuidados Paliat, Badalona, Spain.
   [Ramos-Aguerri, Alfredo] Hosp Ramon & Cajal, Serv Oncol Radioterap, E-28034 Madrid, Spain.
   [Manuel Nunez-Olarte, Juan] Hosp Gen Univ Gregorio Maranon, Unidad Cuidados Paliat, Madrid, Spain.
   [Gascon, Pere] Hosp Clin Barcelona, Med Oncol Serv, Barcelona, Spain.
   [Casas, Ana] Hosp Virgen del Rocio, Serv Oncol, Seville, Spain.
   [Camba, Alberto] CHA Marcide, Serv Anestesiol Reanimac & Tratamiento Dolor, La Coruna, Spain.
   [Camba, Alberto] SED, La Coruna, Spain.
   [Ramon Gonzalez-Escalada, Jose] Hosp Ramon & Cajal, Unidad Dolor, E-28034 Madrid, Spain.
   [Herruzo, Ismael] Hosp Carlos Haya, Serv Oncol Radioterap, Malaga, Spain.
   [Herruzo, Ismael] SEOR, Malaga, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Hospital
   Germans Trias i Pujol; Institut Catala d'Oncologia; Hospital
   Universitario Ramon y Cajal; General University Gregorio Maranon
   Hospital; University of Barcelona; Hospital Clinic de Barcelona; Virgen
   del Rocio University Hospital; Hospital Universitario Ramon y Cajal;
   Hospital Regional Universitario de Malaga
RP Torres, LM (corresponding author), Hosp Univ Puerto del Mar, Serv Anestesia Reanimac & Tratamiento Dolor, Cadiz, Spain.
EM lmtorres@arrakis.es
RI Gascon, Pere/F-7905-2015
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   [No title captured]
NR 114
TC 1
Z9 1
U1 0
U2 1
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1134-248X
J9 MED PALIATIVA
JI Med. Paliativa.
PD APR-JUN
PY 2011
VL 18
IS 2
BP 63
EP 79
PG 17
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 871BM
UT WOS:000298712600005
DA 2026-01-16
ER

PT J
AU Vinjamury, SP
   Li, JT
   Hsiao, E
   Huang, C
   Hawk, C
   Miller, J
   Huang, YH
AF Vinjamury, Sivarama Prasad
   Li, Ju-Tzu
   Hsiao, Eric
   Huang, Calen
   Hawk, Cheryl
   Miller, Judith
   Huang, Yuhong
TI Effects of acupuncture for cancer pain and quality of life - a case
   series
SO CHINESE MEDICINE
LA English
DT Article
ID ALTERNATIVE MEDICINE; COMPLEMENTARY; MALIGNANCIES; RELIABILITY;
   SURVIVORS; EFFICACY; VALIDITY; QLQ-C30; OPIOIDS
AB Background: Many cancer patients seek complementary and alternative medicine (CAM) including acupuncture to manage their cancer-related symptoms or side effects of treatments. Acupuncture is used to manage cancer pain and improve quality of life (QoL). This study aimed to conduct a preliminary study on a case series to evaluate the feasibility of acupuncture for treating cancer pain and to collect preliminary data on the effectiveness of acupuncture in treating cancer pain and improving QoL.
   Methods: A semi-standardized acupuncture treatment comprising one to three treatment sessions (20-30 minutes per session) per week for 8 weeks was provided by four licensed acupuncturists, who had more than 5 years of clinical experience, at the University Health Center. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C3) and a visual analogue scale (VAS) for pain rating were used as the outcome measures to assess pain and QoL. Data were collected at baseline, immediately after 2, 4, 6, and 8 weeks of treatment and at 4 weeks after treatment completion (week 12).
   Results: Two males and five females with a median age of 66 years (range: 44-71 years) completed the study. For the VAS, the percentage of improvement ranged between 18% and 95%. The baseline mean raw score was reduced from 51 mm to 36 mm at the end of week 8 and to 23 mm at the end of week 12. The percentage of overall QoL improvement ranged between 20% and 100%. The mean raw score for QoL improved with time. The baseline score was increased from 55 to 69 at the end of treatment (week 8) and to 73 after the follow-up (week 12).
   Conclusions: This pilot study on a case series showed that acupuncture might be beneficial for reducing pain and improving QoL in cancer patients.
C1 [Vinjamury, Sivarama Prasad; Li, Ju-Tzu; Hsiao, Eric; Miller, Judith] So Calif Univ Hlth Sci, Dept Fundamental Principles, Los Angeles, CA USA.
   [Huang, Calen] China Med Univ, Sch Med, Taichung, Taiwan.
   [Hawk, Cheryl] Logan Coll Chiropract Univ, Dept Res, Chesterfield, MO USA.
   [Huang, Yuhong] United Hlth Grp, Santa Ana, CA USA.
C3 China Medical University Taiwan; UnitedHealth Group Incorporated
RP Vinjamury, SP (corresponding author), So Calif Univ Hlth Sci, Dept Fundamental Principles, Los Angeles, CA USA.
EM sivaramavinjamury@scuhs.edu
RI Vinjamury, Sivarama/AFC-7989-2022
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NR 32
TC 7
Z9 11
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD JUL 30
PY 2013
VL 8
AR 15
DI 10.1186/1749-8546-8-15
PG 6
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 195TE
UT WOS:000322725700001
PM 23895044
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yu, JN
   Guo, CQ
   Hu, B
   Liu, NG
   Sun, HM
   Xu, H
   Wu, HX
   Guo, Y
   Liang, CX
   Chen, ZX
   Li, XH
AF Yu, Jia Ni
   Guo, Chang Qing
   Hu, Bo
   Liu, Nai Gang
   Sun, Hong Mei
   Xu, Hong
   Wu, Hai Xia
   Guo, Yan
   Liang, Chu Xi
   Chen, Zhan Xia
   Li, Xiao Hong
TI Effects of Acupuncture Knife on Inflammatory Factors and Pain in Third
   Lumbar Vertebrae Transverse Process Syndrome Model Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID GROWTH-FACTOR-BETA; SUBSTANCE-P; NEUROINFLAMMATION
AB The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L-3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L-3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1 beta (IL-1 beta), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta (TGF-beta) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-alpha, and TGF-beta, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.
C1 [Yu, Jia Ni; Guo, Chang Qing; Guo, Yan; Liang, Chu Xi; Chen, Zhan Xia; Li, Xiao Hong] Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, Beijing 100029, Peoples R China.
   [Hu, Bo] Beijing Shuili Hosp, Acupuncture & Moxibust & Physiotherapy Dept, Beijing 100036, Peoples R China.
   [Liu, Nai Gang] China Japan Friendship Hosp, Acupuncture & Moxibust Dept, Beijing 100029, Peoples R China.
   [Sun, Hong Mei; Xu, Hong; Wu, Hai Xia] Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; China-Japan Friendship Hospital;
   Beijing University of Chinese Medicine
RP Guo, CQ (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, 11 North 3rd Ring East Rd, Beijing 100029, Peoples R China.
EM guochangqing818@163.com
RI Sun, Hongmei/CAH-6708-2022
OI Guo, Changqing/0000-0003-0393-2674
CR Bardin L, 2011, BEHAV PHARMACOL, V22, P390, DOI 10.1097/FBP.0b013e328349aae4
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NR 22
TC 14
Z9 17
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 892406
DI 10.1155/2014/892406
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AW5CS
UT WOS:000346294100001
PM 25544854
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Chen, LS
   Li, YY
   Chen, H
   Liu, BW
   Wang, DW
   Zhao, YH
AF Chen, Li-Shu
   Li, Yue-Ying
   Chen, Hao
   Liu, Bo-Wen
   Wang, Da-Wei
   Zhao, Yong-Hua
TI Polyglycolic acid sutures embedded in abdominal acupoints for treatment
   of simple obesity in adults: a randomized control trial
SO CHINESE MEDICINE
LA English
DT Article
DE Polyglycolic acid sutures embedding therapy; Simple obesity; Therapeutic
   effects; Regulation of inflammatory response
ID PHYSICAL-ACTIVITY; WEIGHT-LOSS; INFLAMMATION; LIFE; INTERLEUKIN-18;
   ACUPUNCTURE; QUALITY; RISK; DIET
AB Background: Acupoint catgut embedding therapy characterized by acupoint, needle and catgut are superior to traditional acupuncture, due to exerting more comprehensive therapeutic efficacy. However, it is still deficient in clinical evidence for polyglycolic acid sutures, a novel biodegradable material instead of catgut, embedded for the treatment of simple obesity. In our study, we investigate the efficacy and related mechanism of polyglycolic acid sutures embedded in abdominal acupoints on simple obese persons by a randomized control trial.
   Methods: A total of 51 eligible participators were randomly allocated to a polyglycolic acid sutures embedding therapy (PASET) group (n = 28) or control group (n = 23). Participators in PASET group received polyglycolic acid sutures alternatively embedded in abdominal I group and II group acupoints in odd and even number therapeutic courses, and participators in control group were required to perform lifestyle modification. The duration of the study was 10 weeks.
   Results: It suggested that PASET significantly reduced weight, body mass index, hip circumference, waist circumference, waist/hip ratio, waist-to-height ratio and thickness of abdominal subcutaneous fat tissue compared with those before treatment (p < 0.01), but lifestyle modification only illustrated downward trend of weight (p < 0.05). Moreover, PASET group also improved the evaluated scores in aspects of physical function, self-esteem, public distress and sexual life, as well as decreased blood pressure, glycemia, low density lipoprotein, uric acid and the levels of tumor necrosis factor-alpha, interleukin-1 beta, and increased high density lipoprotein in comparison with those before treatment (p < 0.05), whose efficacies are superior to control group. Additionally, our results also indicate PASET is relative safe and its pain and discomfort can be tolerable.
   Conclusions: PASET distinctly ameliorates anthropometric data and quality of life in obese population, which associates with improvements of metabolic profile and inflammatory response. Based on the advantageous actions, we think PASET is an effective therapeutic approach to simple obesity treatment.
C1 [Chen, Li-Shu] Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China.
   [Li, Yue-Ying] Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr, Key Lab Canc Prevent & Therapy,Tianjins Clin Res, Tianjin 300060, Peoples R China.
   [Chen, Hao] Nanjing Univ Chinese Med, Nanjing 210046, Jiangsu, Peoples R China.
   [Liu, Bo-Wen] Nanjing Univ Chinese Med, Dept Neurol, Nanjing Drum Tower Hosp, Clin Coll Tradit Chinese & Western Med, Nanjing 210008, Peoples R China.
   [Wang, Da-Wei] Guangzhou Univ Chinese Med, Shunde Hosp, Shunde 528333, Peoples R China.
   [Zhao, Yong-Hua] Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa 999078, Macao, Peoples R China.
C3 Tianjin Medical University; Nanjing University of Chinese Medicine;
   Nanjing University; Nanjing University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Southern Medical University - China;
   University of Macau
RP Zhao, YH (corresponding author), Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa 999078, Macao, Peoples R China.
EM yonghuazhao@um.edu.mo
RI Wang, Dawei/GYA-0034-2022; Liu, Bowen/OPM-8507-2025; Zhao,
   Yonghua/AAC-4728-2019
OI Zhao, Yonghua/0000-0001-8714-0476
FU Science and Technology Development Fund, Macau SAR [106/2014/A3]
FX This work was funded by The Science and Technology Development Fund,
   Macau SAR (File No. 106/2014/A3).
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NR 37
TC 16
Z9 17
U1 3
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD SEP 18
PY 2019
VL 14
IS 1
AR 32
DI 10.1186/s13020-019-0258-5
PG 9
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA JD5KV
UT WOS:000490022800001
PM 31548850
OA Green Submitted, gold
DA 2026-01-16
ER

PT S
AU Zhuang, Y
   Xing, JJ
   Li, J
   Zeng, BY
   Liang, FR
AF Zhuang, Yi
   Xing, Jing-jing
   Li, Juan
   Zeng, Bai-Yun
   Liang, Fan-rong
BE Zeng, BY
   Zhao, K
   Liang, FR
TI History of Acupuncture Research
SO NEUROBIOLOGY OF ACUPUNCTURE
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID INDUCED POLYCYSTIC OVARIES; CONTROLLED-TRIAL; ELECTROACUPUNCTURE
   STIMULATION; MIGRAINE PROPHYLAXIS; OPIOID RECEPTORS; NEUROPATHIC PAIN;
   RANDOMIZED-TRIAL; BREAST-CANCER; DOUBLE-BLIND; OPIATE
AB The acupuncture has been practiced in China for more than 3000 years and was spread to Europe and American from the sixteenth to the nineteenth century. The history of acupuncture research was initiated in the eighteenth century and developed rapidly since then. In the past, physicians tried hard to apply acupuncture into clinical practice, while scientists were focused on the possible characteristics of acupoints and meridians. In the modern time, scientists have strived hard to evaluate the real effectiveness of acupuncture and the underlying physiological and biological mechanisms of acupuncture. Reviewing research history from past to present, we are delighted to witness this wonderful development. Accumulated evidences that acupuncture is beneficial in various conditions significantly enhanced our understanding the mechanisms of acupuncture treatment. However, there is still no conclusive evidence in acupuncture clinical studies. The clinical research still needs great improving, while the basic research results need to be appropriately transformed into clinical outcomes. Based on current achievements, we believe that although the challenges and difficulties exist, a more collaborative, innovative, and integrated approach will help us to achieve further progress in future acupuncture research.
C1 [Zhuang, Yi; Xing, Jing-jing; Li, Juan; Liang, Fan-rong] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
   [Zeng, Bai-Yun] Kings Coll London, Sch Biomed Sci, Inst Pharmaceut Sci, Neurodegenerat Dis Res Grp, London WC2R 2LS, England.
C3 Chengdu University of Traditional Chinese Medicine; University of
   London; King's College London
RP Liang, FR (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
EM acuresearch@126.com
OI Liang, Fanrong/0000-0003-2210-2027
CR [Anonymous], HYBRIDISING E W
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   [Anonymous], SCI CHINESE
   [Anonymous], INT C SERIES
   [Anonymous], ZHEN CI YAN JIU
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NR 117
TC 168
Z9 197
U1 4
U2 77
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
EI 2162-5514
BN 978-0-12-411545-3
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 111
BP 1
EP 23
DI 10.1016/B978-0-12-411545-3.00001-8
PG 23
WC Integrative & Complementary Medicine; Clinical Neurology; Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA BJP95
UT WOS:000329548500002
PM 24215915
DA 2026-01-16
ER

PT J
AU Carlson, LE
   Reed, EN
   Landmann, J
   Oberoi, D
   Piedalue, KAL
   Faris, PD
AF Carlson, Linda E.
   Reed, Erica N.
   Landmann, Jessa
   Oberoi, Devesh
   Piedalue, Katherine-Ann L.
   Faris, Peter D.
TI GROUP VERSUS INDIVIDUAL ACUPUNCTURE (AP) FOR CANCER PAIN: A RANDOMIZED
   NON-INFERIORITY TRIAL
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Carlson, Linda E.; Reed, Erica N.; Oberoi, Devesh] Univ Calgary, Calgary, AB, Canada.
   [Landmann, Jessa] Vive Integrat Hlth Grp, Calgary, AB, Canada.
   [Piedalue, Katherine-Ann L.] Cumming Sch Med, Calgary, AB, Canada.
   [Faris, Peter D.] Alberta Hlth Serv, Calgary, AB, Canada.
C3 University of Calgary; Alberta Health Services (AHS); University of
   Calgary
EM lcarlso@ucalgary.ca
RI Carlson, Linda/AEN-5702-2022; Faris, Peter/AAJ-3436-2020
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAY
PY 2020
VL 54
SU 1
MA 39
BP S496
EP S496
PG 1
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA MG8ED
UT WOS:000546262401215
DA 2026-01-16
ER

PT J
AU Xie, YF
   Xiao, L
   Zhang, JM
   Tang, H
   Zhou, H
   He, QD
   Zhou, ZM
   Chen, Y
   Guo, ZY
   Wang, Q
   Lin, QC
   Wu, QB
   Chen, M
AF Xie, Yufeng
   Xiao, Lu
   Zhang, Jianmei
   Tang, Hong
   Zhou, Hong
   He, Qida
   Zhou, Zunming
   Chen, Yun
   Guo, Ziyi
   Wang, Qiao
   Lin, Qingchan
   Wu, Qibiao
   Chen, Min
TI MOXIBUSTION AND FIER NEEDLE ACUPUNCTURE FOR GOUTY ARTHRITIS: A
   SYSTEMATIC REVIEW AND META-ANALYSIS
SO JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Gouty arthritis; moxibustion; fire needle acupuncture; systematic
   review; meta-analysis
ID CANCER
AB Background: To assess the effectiveness of moxibustion and fire needle acupuncture for the treatment of gouty arthritis (GA) by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: Seven electronic databases were searched from inception to August 2022 for all RCTs of moxibustion or fire needle acupuncture for GA treatment. Two investigators evaluated the quality of the included studies and extracted data independently. All statistical analyses were performed by RevMan 5.3. Results: Ten RCTs with 653 patients were included after the final screening. The meta-analysis showed that compared with Western medicine, both moxibustion and fire needle acupuncture significantly improved the total effective rate (RR=1.16, 95% CI 1.10-1.23, P<0.00001) and the Comprehensive Joint Swelling and Pain (CSJSP) (RR=3.62, 95% CI 2.99-4.25, P<0.00001) and significantly decreased the uric acid level (RR=19.34, 95% CI 2.07-36.62, P=0.03). Subgroup analyses based on the intervention type showed that either moxibustion or fire needle acupuncture significantly improved the total effective rate and the CSJSP and reduced uric acid levels; however, moxibustion (MD=27.70, 95% CI 19.85-35.54, P<0.00001) was significantly better than fire-acupuncture (MD=-1.05, 95% CI -14.39-12.29, P=0.88) in lowering uric acid levels. Conclusion: This study showed that both moxibustion and fire needle acupuncture are effective for GA patients. Considering the limitations of the included studies such as language bias and small sample size, rigorously designed and high-quality RCTs should be conducted to further evaluate the effectiveness and safety of moxibustion and fire needle acupuncture in treating GA.
C1 [Xie, Yufeng; He, Qida; Guo, Ziyi; Wu, Qibiao; Chen, Min] Macau Univ Sci & Technol, Fac Chinese Med, Macau 999078, Peoples R China.
   [Xie, Yufeng; He, Qida; Guo, Ziyi; Wu, Qibiao; Chen, Min] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China.
   [Xie, Yufeng; Zhang, Jianmei; Tang, Hong; Zhou, Hong; Zhou, Zunming; Chen, Yun; Wang, Qiao; Lin, Qingchan] Guangzhou Univ Chinese Med Futian, Shenzhen Hosp, Shenzhen 518000, Peoples R China.
   [Xiao, Lu] Zhuhai Campus Zunyi Med Univ, Zhuhai 519000, Peoples R China.
C3 Macau University of Science & Technology; Macau University of Science &
   Technology
RP Wu, QB; Chen, M (corresponding author), Macau Univ Sci & Technol, Fac Chinese Med, Macau 999078, Peoples R China.; Wu, QB; Chen, M (corresponding author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China.
EM yufengxie1983@163.com; hbxl1527@163.com; jmzhangdf@163.com;
   982109252@qq.com; 1072715911@qq.com; hokida@163.com; 1194901793@qq.com;
   chenyun15813833533@163.com; guoziyi0904@163.com; mandyqq90@163.com;
   695913794@qq.com; qbwu@must.edu.mo; mchen@must.edu.mo
RI ; guo, ziyi/JFS-6146-2023; Wu, Qibiao/AAA-7621-2019
OI he, qida/0000-0001-6429-4819; Wu, Qibiao/0000-0002-1670-1050
FU Scientific Research Project of Guangdong Provincial Bureau of
   Traditional Chinese Medicine [20232148, 20201324]; Science and
   Technology Development Fund, Macau SAR [0114/2022/A, 0098/2021/A2,
   0048/2023/AFJ]; Chinese Medicine Guangdong Laboratory [HQCML-C-2024006]
FX This study was funded by the Scientific Research Project of Guangdong
   Provincial Bureau of Traditional Chinese Medicine (Nos. 20232148 and
   20201324),the Science and Technology Development Fund, Macau SAR (File
   Nos.: 0114/2022/A, 0098/2021/A2, 0098/2021/A2, and 0048/2023/AFJ), and
   the Chinese Medicine Guangdong Laboratory (HQCML-C-2024006). Yufeng Xie,
   Lu Xiao and JianmeiZhang have contributed equally to this work and
   shared the first authorship.
CR [Anonymous], 2012, Liaoning J Tradit Chin Med
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Caterina MJ, 1997, NATURE, V389, P816, DOI 10.1038/39807
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NR 42
TC 0
Z9 0
U1 6
U2 15
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0219-5194
EI 1793-6810
J9 J MECH MED BIOL
JI J. Mech. Med. Biol.
PD OCT
PY 2024
VL 24
IS 08
DI 10.1142/S0219519424400554
EA AUG 2024
PG 16
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA L9F4F
UT WOS:001296769000001
OA hybrid
DA 2026-01-16
ER

PT J
AU Bermúdez, LIH
   Palacios, LD
   Rosero, ID
   Guil, R
   Ordoñez-Mora, LT
AF Henao Bermudez, Laura Isabel
   Dominguez Palacios, Lawrence
   Rosero, Ilem D.
   Guil, Rocio
   Ordonez-Mora, Leidy Tatiana
TI Effect of educational interventions in pain intensity and related
   outcomes in adults with oncological pain: a systematic review and
   meta-analysis
SO BMJ SUPPORTIVE & PALLIATIVE CARE
LA English
DT Article; Early Access
DE Palliative Care; Pain; Education and training; Supportive care
ID RANDOMIZED CONTROLLED-TRIAL; PATIENT-RELATED BARRIERS; CANCER PAIN;
   SELF-MANAGEMENT; CLINICAL-TRIAL; HOME-CARE; PROGRAM; IMPACT;
   OUTPATIENTS; QUALITY
AB Background Pain is the second most prevalent symptom in patients with cancer after fatigue and is highly debilitating. There is an increasing emphasis on the prescription of non-pharmacological interventions, among which pain education is a prominent option. This study aimed to determine the effects of educational interventions on pain intensity and related outcomes in patients with oncological pain.Methods A systematic review was conducted following Cochrane and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with registration in PROSPERO CRD42022343205 from searches in the main databases such as PubMed, Science Direct, Taylor and Francis, Cochrane (CENTRAL) and Scopus without language restriction, including randomised clinical trials and observational studies using the following keywords: "Pain Education" AND "Cancer". The PEDro (Physiotherapy Evidence Database scale) scale and MINORS (methodological index for non-randomised studies) criteria were used to analyse the risk of bias.Results 35 articles involving the use of educational interventions for patients with cancer pain were analysed in this study. Most protocols involved sessions implementing audiovisual aids, which the patient could easily access. The protocols showed significant results in terms of improvement in pain intensity, stress, quality of life and catastrophising in the intervened groups. Due to the heterogeneity of the interventions in the quantitative analysis, it was only possible to include six articles, which yielded significant results in improving pain (-0.65 (-1.18 to -0.12)).Conclusions It is concluded that educational interventions can be effective in the treatment of cancer pain and should be considered as a complement to palliative care treatment.PROSPERO registration number CRD42022343205.
C1 [Henao Bermudez, Laura Isabel; Dominguez Palacios, Lawrence] Univ Santiago de Cali, Med Program Palmira, Cali, Colombia.
   [Rosero, Ilem D.; Ordonez-Mora, Leidy Tatiana] Univ Santiago de Cali, Dept Hlth, Physiotherapy Program, Cali, Colombia.
   [Guil, Rocio] Univ Cadiz, Dept Psychol, Cadiz, Spain.
C3 Universidad de Cadiz
RP Ordoñez-Mora, LT (corresponding author), Univ Santiago de Cali, Dept Hlth, Physiotherapy Program, Cali, Colombia.
EM laurahenao_99@hotmail.com; law0ren3ce12@gmail.com; ilemdayana@gmail.com;
   rocio.guil@uca.es; tatiana.ormora@gmail.com
RI Guil, Rocio/A-7946-2013; Ordoñez-Mora, Leidy Tatiana/AAL-6397-2021;
   Rosero, Ilem/AHB-1606-2022
OI Guil, Rocio/0000-0003-4425-2800; Ordoñez-Mora, Leidy
   Tatiana/0000-0001-8365-8155; Rosero, Ilem/0000-0001-6843-7047
FU General Directorate of Investigations of Universidad Santiago de Cali
   [DGI 01- 2025]
FX This research has been funded by the General Directorate of
   Investigations of Universidad Santiago de Cali under call No. DGI 01-
   2025.
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NR 76
TC 0
Z9 0
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2045-435X
EI 2045-4368
J9 BMJ SUPPORT PALLIAT
JI BMJ Support. Palliat. Care
PD 2025 JUN 17
PY 2025
DI 10.1136/spcare-2024-005219
EA JUN 2025
PG 10
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 3XP3Y
UT WOS:001511426500001
PM 40527587
DA 2026-01-16
ER

PT J
AU Zhang, D
   Ji, Y
   Lv, L
   Zhou, QY
   Liu, ZJ
   Zhang, CL
   Chen, SS
AF Zhang, Di
   Ji, Yue
   Lv, Liu
   Zhou, Qiongyang
   Liu, Zhijiang
   Zhang, Chenlin
   Chen, Shanshan
TI An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies
   of Acupuncture for Cancer Pain
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE pain; cancer; acupuncture; overview; evidence
ID MANAGEMENT; QUALITY; RISK
AB Background:Systematic reviews (SRs) and meta-analyses (MAs) for the use of acupuncture for cancer pain have been increasing, but the evidence has not been systematically and comprehensively assessed. We aimed to perform an overview of the evidence quality of SRs/MAs of acupuncture for improving cancer pain.Methods:8 databases were systematically searched to identify SRs/MAs of acupuncture for improving cancer pain. The A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2), Risk of Bias in Systematic Reviews (ROBIS), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Grades of Recommendations, Assessment, Development, and Evaluation (GRADE), respectively, were applied by 2 independent reviewers to evaluate the methodological quality, risk of bias, reporting quality, and evidence quality.Results:A total of 14 SRs/MAs were included in the present study. By AMSTAR-2, two reviews were rated as having high methodological quality, while 12 were given a critically low rating. All SRs/MAs in Phase 1, Domain 1, and Domain 4, according to ROBIS, were at low risk. Furthermore, 4 reviews in Domain 2, twelve reviews in Domain 3, and ten SRs/MAs in Phase 3, were rated as having low risk of bias. With reporting quality, some reporting flaws were identified in the topic of protocol and registration, additional analyses, and search strategy. According to GRADE, the level of evidence quality was "critically low" to "moderate," and risk of bias was the most common downgraded factor.Conclusion:Acupuncture may be beneficial in improving cancer pain. However, due to the identified limitations and inconsistent findings, we recommend further rigorous, and more standardized SRs/MAs to provide strong evidence for definitive conclusions.
C1 [Zhang, Di] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan, Peoples R China.
   [Ji, Yue; Zhang, Chenlin] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
   [Lv, Liu] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China.
   [Zhou, Qiongyang] First Peoples Hosp Wenling, Wenling, Peoples R China.
   [Liu, Zhijiang] Gushi Cty Hosp TCM, Gushi, Peoples R China.
   [Chen, Shanshan] Gansu Prov Hosp TCM, Lanzhou, Peoples R China.
   [Chen, Shanshan] Gansu Prov Hosp TCM, 418 Guazhou Rd, Lanzhou City 730050, Gansu Province, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Beijing University of Chinese Medicine
RP Chen, SS (corresponding author), Gansu Prov Hosp TCM, 418 Guazhou Rd, Lanzhou City 730050, Gansu Province, Peoples R China.
EM csstcm@163.com
OI LV, Liu/0000-0002-1349-1959
FU Not Applicable.
FX Not Applicable.
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NR 50
TC 4
Z9 4
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231210288
DI 10.1177/15347354231210288
PG 11
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA X5YH9
UT WOS:001099201600001
PM 37942632
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Paley, C
AF Paley, Carole
TI Acupuncture for the treatment of cancer pain: a systematic review.
   Response to authors
SO SUPPORTIVE CARE IN CANCER
LA English
DT Letter
C1 Airedale NHS Fdn Trust, Keighley, W Yorkshire, England.
RP Paley, C (corresponding author), Airedale NHS Fdn Trust, Keighley, W Yorkshire, England.
EM carolepaley2@btinternet.com
RI Paley, Carole Anne/AAM-2469-2020
OI Paley, Carole Anne/0000-0002-6335-2666
CR Choi TY, 2012, SUPPORT CARE CANCER, V20, P1147, DOI 10.1007/s00520-012-1432-9
NR 1
TC 0
Z9 0
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD MAY
PY 2013
VL 21
IS 5
BP 1217
EP 1217
DI 10.1007/s00520-012-1704-4
PG 1
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 117OK
UT WOS:000316962600002
PM 23306936
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhang, CP
   Xia, C
   Zhang, XW
   Li, WM
   Miao, XR
   Zhou, QH
AF Zhang, Chunpeng
   Xia, Chen
   Zhang, Xiaowen
   Li, Weimin
   Miao, Xuerong
   Zhou, Qinghui
TI Wrist-ankle acupuncture attenuates cancer-induced bone pain by
   regulating descending pain-modulating system in a rat model
SO CHINESE MEDICINE
LA English
DT Article
DE Wrist-ankle acupuncture; Electroacupuncture; Cancer pain; Descending
   modulation
ID VENTROMEDIAL MEDULLA; MURINE MODEL; RECEPTOR; ELECTROACUPUNCTURE;
   EXPRESSION; MU; HYPERALGESIA; MECHANISMS; ANALGESIA; ENDOMORPHIN-1
AB Background Cancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and its pathogenesis is closely related to endogenous descending system of pain control. However, the action mechanism underlying the effects of wrist-ankle acupuncture (WAA) versus electroacupuncture (EA) on CIBP remains unknown. Methods Thirty-two Wistar rats were divided into sham, CIBP, EA-treated and WAA-treated groups. CIBP was induced in rats of the latter three groups. Time courses of weight and mechanical hyperalgesia threshold (MHT) were evaluated. After 6 days of EA or WAA treatment, the expressions of 5-hydroxytryotamine type 3A receptor (5-HT3AR) and mu-opioid receptor (MOR) in rostral ventromedial medulla (RVM) and/or spinal cord, as well as the levels of 5-HT, beta-endorphin, endomorphin-1 and endomorphin-2 in RVM and spinal cord, were detected. Results Injection of cancer cells caused decreased MHT, which was attenuated by EA or WAA (P < 0.05). WAA had a quicker analgesic effect than EA (P < 0.05). No significant difference of MOR in RVM was found among the four groups. EA or WAA counteracted the cancer-driven upregulation of 5-HT3AR and downregulation of MOR in spinal cord (P < 0.05), and upregulation of 5-HT and downregulation of endomorphin-1 in both RVM and spinal cord (P < 0.05). beta-endorphin and endomorphin-2 in RVM and spinal cord decreased in CIBP group compared with sham group (P < 0.05), but EA or WAA showed no significant effect on them, although a tendency of increasing effect was observed. Conclusion WAA, similar to EA, alleviated mechanical hyperalgesia in CIBP rats by suppressing the expressions of 5-HT and 5-HT3AR, and increasing the expressions of MOR and endomorphin-1 in RVM-spinal cord pathway of the descending pain-modulating system. However, WAA produced a quicker analgesic effect than EA, the mechanisms of which need further investigation.
C1 [Zhang, Chunpeng; Xia, Chen; Zhang, Xiaowen; Zhou, Qinghui] Naval Med Univ, Sch Tradit Chinese Med, Changhai Hosp, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Li, Weimin] Fudan Univ, Shanghai Med Coll, Lab Neuronal Network & Syst Biol, Shanghai 200032, Peoples R China.
   [Miao, Xuerong] Naval Med Univ, Dept Anesthesiol, Eastern Hepatobiliary Surg Hosp, 225 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Fudan University; Naval Medical University
RP Zhou, QH (corresponding author), Naval Med Univ, Sch Tradit Chinese Med, Changhai Hosp, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Miao, XR (corresponding author), Naval Med Univ, Dept Anesthesiol, Eastern Hepatobiliary Surg Hosp, 225 Changhai Rd, Shanghai 200433, Peoples R China.
EM miaoxr@smmu.edu.cn; qinghui2016@163.com
FU National Natural Science Foundation of China [81373756]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81373756).
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NR 60
TC 21
Z9 30
U1 5
U2 27
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD FEB 4
PY 2020
VL 15
IS 1
AR 13
DI 10.1186/s13020-020-0289-y
PG 13
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA KL8BY
UT WOS:000513643700001
PM 32042305
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lau, CHY
   Wu, XY
   Chung, VCH
   Liu, X
   Hui, EP
   Cramer, H
   Lauche, R
   Wong, SYS
   Lau, AYL
   Sit, RST
   Ziea, ETC
   Ng, BFL
   Wu, JCY
AF Lau, Charlotte H. Y.
   Wu, Xinyin
   Chung, Vincent C. H.
   Liu, Xin
   Hui, Edwin P.
   Cramer, Holger
   Lauche, Romy
   Wong, Samuel Y. S.
   Lau, Alexander Y. L.
   Sit, Regina S. T.
   Ziea, Eric T. C.
   Ng, Bacon F. L.
   Wu, Justin C. Y.
TI Acupuncture and Related Therapies for Symptom Management in Palliative
   Cancer Care Systematic Review and Meta-Analysis
SO MEDICINE
LA English
DT Review
ID OPTIMAL SEARCH STRATEGIES; ADVERSE EVENTS; FATIGUE; PAIN; HYPOGONADISM;
   CHEMOTHERAPY; SURVIVAL; QUALITY; BURDEN
AB Available systematic reviews showed uncertainty on the effectiveness of using acupuncture and related therapies for palliative cancer care.
   The aim of this systematic review and meta-analysis was to summarize current best evidence on acupuncture and related therapies for palliative cancer care.
   Five international and 3 Chinese databases were searched. Randomized controlled trials (RCTs) comparing acupuncture and related therapies with conventional or sham treatments were considered. Primary outcomes included fatigue, paresthesia and dysesthesias, chronic pain, anorexia, insomnia, limb edema, constipation, and health-related quality of life, of which effective conventional interventions are limited.
   Thirteen RCTs were included. Compared with conventional interventions, meta-analysis demonstrated that acupuncture and related therapies significantly reduced pain (2 studies, n = 175, pooled weighted mean difference: -0.76, 95% confidence interval: -0.14 to -0.39) among patients with liver or gastric cancer. Combined use of acupuncture and related therapies and Chinese herbal medicine improved quality of life in patients with gastrointestinal cancer (2 studies, n = 111, pooled standard mean difference: 0.75, 95% confidence interval: 0.36-1.13). Acupressure showed significant efficacy in reducing fatigue in lung cancer patients when compared with sham acupressure. Adverse events for acupuncture and related therapies were infrequent and mild.
   Acupuncture and related therapies are effective in reducing pain, fatigue, and in improving quality of life when compared with conventional intervention alone among cancer patients. Limitations on current evidence body imply that they should be used as a complement, rather than an alternative, to conventional care. Effectiveness of acupuncture and related therapies for managing anorexia, reducing constipation, paresthesia and dysesthesia, insomnia, and limb edema in cancer patients is uncertain, warranting future RCTs in these areas.
C1 [Lau, Charlotte H. Y.] Chinese Univ Hong Kong, Fac Med, Hong Kong, Hong Kong, Peoples R China.
   [Wu, Xinyin; Chung, Vincent C. H.; Hui, Edwin P.; Wong, Samuel Y. S.; Lau, Alexander Y. L.; Sit, Regina S. T.; Wu, Justin C. Y.] Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Hong Kong, Hong Kong, Peoples R China.
   [Wu, Xinyin; Chung, Vincent C. H.; Liu, Xin; Wong, Samuel Y. S.; Sit, Regina S. T.] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.
   [Hui, Edwin P.] Chinese Univ Hong Kong, Comprehens Canc Trials Unit, Hong Kong, Hong Kong, Peoples R China.
   [Cramer, Holger] MitteUniv Duisburg Essen, Kliniken Essen, Fac Med, Dept Internal & Integrat Med, Essen, Germany.
   [Cramer, Holger] Univ Technol Sydney, Fac Hlth, ARCCIM, Sydney, NSW 2007, Australia.
   [Lau, Alexander Y. L.; Wu, Justin C. Y.] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
   [Ziea, Eric T. C.; Ng, Bacon F. L.] Hong Kong Hosp Author, Chinese Med Dept, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Chinese University of Hong Kong;
   University of Technology Sydney; Chinese University of Hong Kong
RP Chung, VCH (corresponding author), Prince Wales Hosp, 4-F Sch Publ Hlth Bldg, Shatin, Hong Kong, Peoples R China.
EM vchung@cuhk.edu.hk
RI Lau, Alexander/N-2485-2015; Wong, Samuel Yeung Shan/D-7311-2013; Ng,
   Bacon F L/I-5554-2013; Lauche, Romy/AAQ-7175-2021; Cramer,
   Holger/AAH-1794-2019; Hui, Edwin/ABC-1818-2021; Wu, Justin/N-6916-2015;
   Sit, Regina/V-9982-2017; Chung, Vincent Chi Ho/K-2447-2013
OI Lau, Alexander/0000-0002-5933-9290; Wong, Samuel Yeung
   Shan/0000-0003-0934-6385; Ng, Bacon F L/0000-0003-1682-8382; Lauche,
   Romy/0000-0002-4171-7935; Chung, Vincent Chi Ho/0000-0002-5947-4492
FU Hospital Authority of Hong Kong [8110016609]
FX This systematic review was funded by Hospital Authority of Hong Kong
   (Reference number: 8110016609).
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NR 47
TC 98
Z9 118
U1 4
U2 72
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR
PY 2016
VL 95
IS 9
AR e2901
DI 10.1097/MD.0000000000002901
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DK8WI
UT WOS:000375208900010
PM 26945382
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chien, TJ
   Liu, CY
   Fang, CJ
   Kuo, CY
AF Chien, Tsai-Ju
   Liu, Chia-Yu
   Fang, Ching-Ju
   Kuo, Chun-Yu
TI The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral
   Neuropathy: Systematic Review and Meta-Analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; cancer; chemotherapy; neuropathy; systematic review
ID MULTIPLE-MYELOMA; CANCER PAIN; NEUROTOXICITY; ELECTROACUPUNCTURE;
   VINCRISTINE; PREVENTION; GLUTAMINE; QUALITY
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) has no cure, but acupuncture may provide relief through its known neuromodulation or neuroendocrine adjustment. This review aimed to assess the efficacy of acupuncture in treating CIPN. Method: A literature review following the PRISMA Statement was performed, searching 7 databases from inception through August 2019. All studies were clinical trials of the effect of acupuncture on CIPN. The methodological quality of these trials was assessed using Cochrane criteria; meta-analysis software (RevMan 5.2) was used to analyze the data. Data Sources: The databases searched were the following: MEDLINE (Ovid), Embase, Cochrane CENTRAL, Scopus, World Health Organization International Clinical Trials Registry Platform, CNKI (China National Knowledge Infrastructure), and Wanfang Med Online. Results: We examined 386 cancer patients from 6 randomized control trials, which had high quality, based on the modified Jadad scale. Meta-analysis showed that acupuncture led to significant improvements in pain scores (-1.21, 95% confidence interval [CI] = -1.61 to -0.82, P < .00001) and nervous system symptoms based on Functional Assessment of Cancer Therapy/Neurotoxicity questionnaire scores (-2.02, 95% CI = -2.21 to -1.84, P < .00001). No significant change was noted in nerve conduction velocity (1.58, 95% CI = -2.67 to 5.83, P = .47). Conclusion: Acupuncture can effectively relieve CIPN pain and functional limitation. The limited number of subjects warrants a larger scale study.
C1 [Chien, Tsai-Ju] Taipei City Hosp, Taipei, Taiwan.
   [Chien, Tsai-Ju; Liu, Chia-Yu; Kuo, Chun-Yu] Natl Yang Ming Univ, Taipei, Taiwan.
   [Liu, Chia-Yu] Chang Gung Univ, Taoyuan, Taiwan.
   [Liu, Chia-Yu] China Med Univ, Taichung, Taiwan.
   [Liu, Chia-Yu] Flourish Tradit Chinese Med Clin, Taipei, Taiwan.
   [Fang, Ching-Ju] Natl Cheng Kung Univ, Tainan, Taiwan.
   [Fang, Ching-Ju] Natl Cheng Kung Univ Hosp, Tainan, Taiwan.
C3 Taipei City Hospital; National Yang Ming Chiao Tung University; Chang
   Gung University; China Medical University Taiwan; National Cheng Kung
   University; National Cheng Kung University; National Cheng Kung
   University Hospital
RP Chien, TJ (corresponding author), Taipei City Hosp, Dept Internal Med, Div Hematooncol, Branch Zhong Zhou & Jen Ai, 87 Tong De Rd, Taipei 11556, Taiwan.
EM silence021@gmail.com
RI ; Fang, Ching-Ju/B-4221-2009
OI Chien, Tsai Ju/0000-0001-9646-5272; Fang, Ching-Ju/0000-0002-7892-8840
FU Ministry of Science and Technology [108-2320-B-532-001-MY3]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by grants from Ministry of Science and
   Technology, 108-2320-B-532-001-MY3.
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NR 65
TC 43
Z9 51
U1 4
U2 27
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD DEC
PY 2019
VL 18
AR 1534735419886662
DI 10.1177/1534735419886662
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA JW0KL
UT WOS:000502748200001
PM 31833790
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Villegas, F
   Martínez-Borba, V
   Suso-Ribera, C
   Castilla, D
   Zaragoza, I
   García-Palacios, A
   Ferrer, C
AF Villegas, Francisco
   Martinez-Borba, Veronica
   Suso-Ribera, Carlos
   Castilla, Diana
   Zaragoza, Irene
   Garcia-Palacios, Azucena
   Ferrer, Carlos
TI Characterizing Breakthrough Cancer Pain Using Ecological Momentary
   Assessment with a Smartphone App: Feasibility and Clinical Findings
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE breakthrough cancer pain; ecological momentary assessment; smartphone
   application; pain management; pain characterization
ID LOW-BACK-PAIN; AMERICAN SOCIETY; MANAGEMENT; PREVALENCE; FATIGUE;
   SYMPTOMS; FENTANYL; EFFICACY; BELIEFS; SYSTEM
AB Background: mobile applications (apps) facilitate cancer pain ecological momentary assessment (EMA) and provide more reliable data than retrospective monitoring. The aims of this study are (a) to describe the status of persons with cancer pain when assessed ecologically, (b) to analyze the utility of clinical alarms integrated into the app, and (c) to test the feasibility of implementing an app for daily oncological pain monitoring. Methods: in this feasibility study, 21 patients (mean age = 56.95 years, SD = 10.53, 81.0% men) responded to an app-based evaluation of physical status (baseline and breakthrough cancer pain (BTcP)) and mental health variables (fatigue, mood, and coping) daily during 30 days. Results: cancer pain characterization with the app was similar to data from the literature using retrospective assessments in terms of BTcP duration and perceived medication effectiveness. However, BTcP was less frequent when evaluated ecologically. Pain, fatigue, and mood were comparable in the morning and evening. Passive coping strategies were the most employed daily. Clinical alarms appear to be useful to detect and address adverse events. App implementation was feasible and acceptable. Conclusion: apps reduce recall bias and facilitate a rapid response to adverse events in oncological care. Future efforts should be addressed to integrate EMA and ecological momentary interventions to facilitate pain self-management via apps.
C1 [Villegas, Francisco; Ferrer, Carlos] Consorcio Hosp Prov Castellon, Pain & Radiotherapy Units, Castellon de La Plana 12002, Spain.
   [Martinez-Borba, Veronica; Suso-Ribera, Carlos; Garcia-Palacios, Azucena] Univ Jaume 1, Dept Basic & Clin Psychol & Psychobiol, Castellon de La Plana 12071, Spain.
   [Martinez-Borba, Veronica] Inst Invest Sanitaria Aragon, Zaragoza 50009, Spain.
   [Castilla, Diana] Univ Valencia, Dept Personal Assessment & Psychol Treatments, Valencia 46010, Spain.
   [Castilla, Diana; Zaragoza, Irene; Garcia-Palacios, Azucena] CIBER Physiopathol Obes & Nutr CIBERON, Madrid 28029, Spain.
C3 Universitat Jaume I; University of Valencia
RP Suso-Ribera, C (corresponding author), Univ Jaume 1, Dept Basic & Clin Psychol & Psychobiol, Castellon de La Plana 12071, Spain.
EM franvilles@hotmail.com; borba@uji.es; susor@uji.es;
   diana.castilla@uv.es; irenezaragoza@gmail.com; azucena@uji.es;
   carlos.ferrer@hospitalprovincial.es
RI Castilla, Diana/S-3733-2019; Suso-Ribera, Carlos/D-3770-2018; Zaragozá,
   Irene/AAH-8893-2021; García-Palacios, Azucena/C-9854-2011;
   Martínez-Borba, Verónica/AAN-1046-2020
OI Castilla, Diana/0000-0002-1631-1220; Suso-Ribera,
   Carlos/0000-0002-2655-1017; Zaragozá, Irene/0000-0001-6659-6183;
   García-Palacios, Azucena/0000-0001-9250-8714; Martínez-Borba,
   Verónica/0000-0003-2082-8115
FU CASTELLON PROVINCIAL HOSPITAL FOUNDATION [CAF-16-033, CAF-21-014]
FX This research was funded by CASTELLON PROVINCIAL HOSPITAL FOUNDATION,
   grant number CAF-16-033 and CAF-21-014.
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NR 68
TC 13
Z9 15
U1 1
U2 19
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN
PY 2021
VL 18
IS 11
AR 5991
DI 10.3390/ijerph18115991
PG 21
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA SP9DR
UT WOS:000659963200001
PM 34204871
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chiaramonte, R
   Bonfiglio, M
   Caramma, S
   Condorelli, R
AF Chiaramonte, Rita
   Bonfiglio, Marco
   Caramma, Salvatore
   Condorelli, Rosaria
TI The Role of Rehabilitation in the Treatment of Constipation in
   Oncological Patients
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE neoplasms; constipation; rehabilitation; osteopathy
ID OPIOID-INDUCED CONSTIPATION; QUALITY-OF-LIFE; CANCER-PATIENTS;
   CHEMOTHERAPY; PREVALENCE; IMPACT; ELECTROACUPUNCTURE; ACUPRESSURE;
   THERAPY
AB Background: Chemotherapy, as well as opioid and antiemetic drugs, can contribute to constipation in oncological patients. This systematic review aims to analyse the potential of specific rehabilitation strategies and alternative strategies for improving constipation symptoms, with the goal of incorporating these strategies into a dedicated protocol for managing cancer-related constipation. This could potentially reduce the dosages of or eliminate the need for constipation medications. Methods: A systematic search was conducted on PubMed, Scopus and Web of Science. The review included studies analysing constipation complaints in cancer patients treated with rehabilitation, acupuncture and osteopathy. Results: The review included 16 studies in line with PRISMA and PICOS criteria. Most studies showed that physical exercise, abdominal massage, TENS, acupuncture and education on the correct defecation position positively impacted the management of constipation and quality of life in oncological patients. A physiotherapy program involving massages as well as aerobic and resistance training improved constipation in oncological women, regardless of age, sex and frailty. A combination of abdominal massage, abdominal muscle stretching and education on proper defecation position alleviated the severity of constipation and related depression. However, the outcomes regarding TENS were yet inconsistent. Another technique, becoming increasingly common for constipation, and demonstrating positive results, involved stimulating trigger points through acupressure and acupuncture. Conversely, osteopathic and superficial manipulations more frequently required constipation medications than did the other alternative approaches. However, no existing studies have proposed a specific protocol to manage cancer-related constipation. Conclusions: The results of the studies confirm the positive influences of rehabilitation, osteopathy and acupuncture on constipation and pain in oncological patients. Nevertheless, further studies are required to establish the best type, timing and duration of treatment, as well as how the stage and location of the cancer and the cause of constipation (drug-induced or functional) impact the results.
C1 [Chiaramonte, Rita] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.
   [Bonfiglio, Marco] Prov Hlth Dept Siracusa, I-96014 Sicily, Italy.
   [Caramma, Salvatore] Policlin San Marco Hosp, Dept Pain Management, I-95123 Catania, Italy.
   [Condorelli, Rosaria] Ist Oncol Svizzera Italiana, Dept Med Oncol, EOC, CH-6500 Bellinzona, Switzerland.
C3 University of Catania; Institute of Oncology Research (IOR)
RP Chiaramonte, R (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.; Bonfiglio, M (corresponding author), Prov Hlth Dept Siracusa, I-96014 Sicily, Italy.
EM ritachiaramd@gmail.com; mrc.bnf@hotmail.it; salvacaramma@tiscali.it;
   rosaria.condorelli@eoc.ch
OI Chiaramonte, Rita/0000-0003-1256-7605
CR Azmanova M, 2022, CHEMBIOCHEM, V23, DOI 10.1002/cbic.202100641
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NR 47
TC 9
Z9 9
U1 0
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2023
VL 12
IS 15
AR 5083
DI 10.3390/jcm12155083
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O7IZ9
UT WOS:001045516400001
PM 37568485
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yao, ZQ
   Xu, ZB
   Xu, TL
   Liu, XW
   Xu, S
   Wan, CJ
   Zhou, X
AF Yao, Ziqian
   Xu, Zhongbo
   Xu, Tielong
   Liu, Xiaowu
   Xu, Sheng
   Wan, Chanjun
   Zhou, Xu
TI Moxibustion for alleviating chemotherapy-induced gastrointestinal
   adverse effects: A systematic review of randomized controlled trials
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Review
DE Moxibustion; Gastrointestinal adverse effects; Chemotherapy; Malignant
   tumours; Systematic review
ID ULCERATIVE-COLITIS; ACUPUNCTURE; NAUSEA
AB Objective: This systematic review aims to assess whether moxibustion is effective and safe for gastrointestinal adverse effects, a common and thorny issue arising from chemotherapy.
   Methods: Seven electronic databases were searched up to August 28, 2021, to identify randomized controlled trials (RCTs) comparing moxibustion versus non-moxibustion treatments for various gastrointestinal adverse effects after chemotherapy. The Karnofsky performance status (KPS) and quality of life scores and the incidence of moxibustion-related adverse events were also investigated. Effects in meta-analyses were measured by risk ratios (RRs) or mean differences (MDs).
   Results: Thirty-two RCTs (n = 2990) were included. Compared to the controls, moxibustion significantly reduced the incidences of nausea/vomiting (RR 0.70, 95% CI 0.61-0.79), severe nausea/vomiting (RR 0.39, 95% CI 0.29-0.51), diarrhoea (RR 0.56, 95% CI 0.38-0.82), constipation (RR 0.59, 95% CI 0.44-0.78), and abdominal distension (RR 0.60, 95% CI 0.46-0.78). The KPS (MD 7.53, 95% CI 3.42-11.64) and quality of life (MD 8.88, 95% CI 0.96-16.80) scores were also significantly improved after moxibustion. The results did not support a benefit of moxibustion on inappetence (RR 0.69, 95% CI 0.40-1.22) or abdominal pain (RR 0.60, 95% CI 0.28-1.30). All adverse events related to moxibustion were mild.
   Conclusions: Moderate-to very-low-quality evidence suggests that moxibustion may be safely used as an adjuvant treatment after chemotherapy to reduce the incidences of nausea and vomiting, diarrhoea, constipation, and abdominal distension and improve the performance status and quality of life in patients with malignant tumours. Its effects on abdominal pain and inappetence are uncertain.
C1 [Yao, Ziqian; Xu, Tielong; Liu, Xiaowu; Xu, Sheng; Zhou, Xu] Jiangxi Univ Chinese Med, Evidence based Med Res Ctr, Nanchang, Peoples R China.
   [Xu, Zhongbo] Jiangxi Univ Chinese Med, Dept Emergency, Affiliated Hosp, Nanchang, Peoples R China.
   [Wan, Chanjun] Jiangxi Univ Chinese Med, Dept Cardiol, Affiliated Hosp, Nanchang, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; Jiangxi University of Traditional
   Chinese Medicine
RP Zhou, X (corresponding author), Jiangxi Univ Chinese Med, Evidence based Med Res Ctr, Nanchang, Peoples R China.; Wan, CJ (corresponding author), Jiangxi Univ Chinese Med, Dept Cardiol, Affiliated Hosp, Nanchang, Peoples R China.
EM yaoziqian@hotmail.com; 103977986@qq.com; jxciq_xtl@126.com;
   lxw970309@163.com; 29576964@qq.com; vanjun86@163.com;
   zhouxu_ebm@hotmail.com
RI xu, sheng/KMX-9932-2024; Tie-Long, Xu/GZA-9502-2022
OI Tie-Long, Xu/0000-0001-9432-9584
FU National Natural Science Foundation China [81904057]; Degree and
   Postgraduate Education Reform Project of Jiangxi University of Chinese
   Medicine [JZYJG-19-05]; Education Science 13th Five-year Plan Project of
   Jiangxi Province [20YB148]; Teaching Reform Project of Colleges and
   Universities Jiangxi province [JXJG-19-12-14]; Jiangxi University of
   Chi-nese Medicine [5142001011]
FX & nbsp;This work is supported by National Natural Science Foundation
   China [No. 81904057] , Degree and Postgraduate Education Reform Project
   of Jiangxi University of Chinese Medicine [No. JZYJG-19-05] , Education
   Science 13th Five-year Plan Project of Jiangxi Province [No. 20YB148] ,
   Teaching Reform Project of Colleges and Universities Jiangxi province
   [No. JXJG-19-12-14] , and Jiangxi University of Chi-nese Medicine 1050
   Youth Talent Project [No. 5142001011] . All funders had no role during
   the entire process of this study.
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NR 79
TC 13
Z9 14
U1 1
U2 62
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD FEB
PY 2022
VL 46
AR 101527
DI 10.1016/j.ctcp.2021.101527
EA JAN 2022
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0X3RQ
UT WOS:000789628400014
PM 34999499
DA 2026-01-16
ER

PT J
AU Djaali, W
AF Djaali, W.
TI Integrating acupuncture in palliative care for elderly patients with
   cancer pain due to spinal metastasis
SO ANNALS OF ONCOLOGY
LA English
DT Meeting Abstract
C1 [Djaali, W.] Univ Indonesia, Univ Indonesia Hosp, Fac Med, Med Acupuncture Study Program, Depok, Indonesia.
C3 University of Indonesia
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD OCT
PY 2025
VL 36
SU 3
MA P51-4
BP S1738
EP S1738
DI 10.1016/j.annonc.2025.08.354
PG 1
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O1031
UT WOS:001632241300105
DA 2026-01-16
ER

PT J
AU Ruela, LD
   Iunes, DH
   Nogueira, DA
   Stefanello, J
   Gradim, CVC
AF Ruela, Ludmila de Oliveira
   Iunes, Denise Hollanda
   Nogueira, Denismar Alves
   Stefanello, Juliana
   Cortes Gradim, Clicia Valim
TI Effectiveness of auricular acupuncture in the treatment of cancer pain:
   randomized clinical trial
SO REVISTA DA ESCOLA DE ENFERMAGEM DA USP
LA Portuguese
DT Article
DE Acupuncture; Ear; Complementary Therapies; Pain; Neoplasms; Oncology
   Nursing
ID MANAGEMENT
AB Objective: To evaluate the effectiveness of auricular acupuncture in the pain of cancer patients receiving chemotherapy and to verify if there were alterations in the use of analgesics after the application of this intervention. Method: Randomized controlled trial with cancer patients with complaints of pain greater than or equal to four in the Numerical Pain Scale. Two parallel groups were created, an Experimental group, which received auricular acupuncture at energy balance points and at points indicated for the treatment of pain, and a Placebo group, in which fixed placebo points were used. Both groups received the application of semipermanent needles in eight sessions. Results: 31 cancer patients participated in the study. After the eight auricular acupuncture sessions, there was a significant difference between the groups regarding the reduction of pain intensity (p < 0.001) and of the use of medications (p < 0.05). Conclusion: Auricular acupuncture was effective in reducing the pain of patients receiving chemotherapy.
C1 [Ruela, Ludmila de Oliveira; Cortes Gradim, Clicia Valim] Univ Fed Alfenas, Escola Enfermagem, Alfenas, MG, Brazil.
   [Iunes, Denise Hollanda] Univ Fed Alfenas, Inst Ciencias Motricidade Alfenas, Alfenas, MG, Brazil.
   [Nogueira, Denismar Alves] Univ Fed Alfenas, Inst Ciencias Exatas, Dept Estat, Alfenas, MG, Brazil.
   [Stefanello, Juliana] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, Dept Maternoinfantil & Saude Publ, Ribeirao Preto, SP, Brazil.
C3 Universidade Federal de Alfenas; Universidade Federal de Alfenas;
   Universidade Federal de Alfenas; Universidade de Sao Paulo
RP Ruela, LD (corresponding author), Rua Joao Pinheiro 203, BR-37140000 Areado, MG, Brazil.
EM ludmilaoliveira.r@hotmail.com
RI Gradim, Clicia/V-6065-2019; Iunes, Denise/AAF-6014-2019; Stefanello,
   Juliana/I-7033-2013; A Nogueira, Denismar/A-6605-2017; Oliveira Ruela,
   Ludmila/AAB-7029-2019
OI Iunes, Denise/0000-0003-1396-9980; A Nogueira,
   Denismar/0000-0003-2285-8764; Oliveira Ruela,
   Ludmila/0000-0001-9071-539X
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NR 31
TC 31
Z9 41
U1 1
U2 34
PU UNIV SAO PAOLO
PI CERQUERA CESAR
PA AV  DR ENEAS DE CARVALHO AGUIAR, 419, CERQUERA CESAR, SP 05403-000,
   BRAZIL
SN 0080-6234
EI 1980-220X
J9 REV ESC ENFERM USP
JI Rev. Esc. Enferm. USP
PY 2018
VL 52
AR e03402
DI 10.1590/S1980-220X2017040503402
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HF0OT
UT WOS:000453862200002
PM 30570087
OA Green Submitted, Green Published, gold
DA 2026-01-16
ER

PT J
AU Li, YY
   Xu, RY
   Chen, MY
   Zheng, KG
   Nie, HM
   Yin, CY
   Liu, BY
   Tai, Y
   Du, JY
   Wang, J
   Fang, JQ
   Liu, BY
AF Li, Yuanyuan
   Xu, Ruoyao
   Chen, Muyan
   Zheng, Kaige
   Nie, Huimin
   Yin, Chengyu
   Liu, Boyu
   Tai, Yan
   Du, Junying
   Wang, Jie
   Fang, Jianqiao
   Liu, Boyi
TI Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy
   by reducing CCL2-mediated macrophage infiltration in sensory ganglia and
   sciatic nerve
SO CHINESE MEDICINE
LA English
DT Article
DE Paclitaxel; Chemotherapy; Neuropathy; Macrophages; Acupuncture; Pain
ID MOUSE MODEL; CHEMOTHERAPY; PAIN; ACUPUNCTURE; CONTRIBUTES; NEURONS;
   MEDIATE; CELLS; RATS
AB BackgroundPaclitaxel-induced peripheral neuropathy (PIPN) is prevalent among patients receiving paclitaxel chemotherapy, which results in sensory abnormality as well as neuropathic pain. Conventional medications lack effectiveness on PIPN. Clinical trials identified beneficial effects of acupuncture on PIPN among patients receiving chemotherapy. Here we explored the mechanisms underlying how acupuncture might alleviate PIPN.MethodsA mouse model of PIPN was established by repeated paclitaxel application. Electroacupuncture (EA) was applied at ST36 and BL60 acupoints of model mice. Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration.ResultsEA ameliorated mechanical and cold pain hypersensitivities, reduced sensory neuron damage and improved loss in intra-epidermal nerve fibers (IENFs) in model mice. Macrophages infiltration were detected in DRG and sciatic nerve of model mice, which was reduced by EA. EA affected M1-like pro-inflammatory macrophage infiltration in DRG, whereas it did not affect M2-like macrophages. DRG neurons released chemoattractant CCL2 that recruited macrophages via CCR2 to DRG. EA reduced CCL2 overproduction by DRG neurons and reduced macrophage infiltration. Blocking CCR2 mimicked EA's anti-allodynic effect, whereas exogenously applying recombinant CCL2 reversed the ameliorative effect of EA on macrophage infiltration and abolished EA's anti-allodynia on model mice. EA ameliorated other signs of PIPN, including sensory neuron damage, sciatic nerve morphology impairment and IENFs loss. In mice inoculated with breast cancer cells, EA didn't affect paclitaxel-induced antitumor effect.ConclusionsThese findings suggest EA alleviates PIPN by reducing CCL2/CCR2 mediated-pro-inflammatory macrophage infiltration into sensory ganglia as well as the sciatic nerve. Our study supports EA could be used as a potential non-pharmacological therapy for PIPN.
C1 [Li, Yuanyuan; Xu, Ruoyao; Chen, Muyan; Zheng, Kaige; Nie, Huimin; Yin, Chengyu; Liu, Boyu; Du, Junying; Fang, Jianqiao; Liu, Boyi] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.
   [Tai, Yan] Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Hangzhou, Peoples R China.
   [Wang, Jie] Zhejiang Univ, Affiliated Hosp 2, Dept Rehabil Tradit Chinese Med, Sch Med, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang University
RP Fang, JQ; Liu, BY (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China.; Wang, J (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Dept Rehabil Tradit Chinese Med, Sch Med, Hangzhou, Peoples R China.
EM wangjiee@zju.edu.cn; fangjianqiao7532@163.com; boyi.liu@foxmail.com
RI Du, Junying/AEV-3719-2022; Yin, Chengyu/NLN-8501-2025
FU Key Technologies Research and Development Program; Academy of Chinese
   Medical Sciences, Zhejiang Chinese Medical University
FX We thank the Academy of Chinese Medical Sciences, Zhejiang Chinese
   Medical University for the technical assistance.
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NR 55
TC 4
Z9 6
U1 11
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD JAN 13
PY 2025
VL 20
IS 1
AR 9
DI 10.1186/s13020-024-01023-8
PG 18
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA S2S2N
UT WOS:001396778800001
PM 39806462
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, XT
   Baser, RE
   Bryl, K
   Amann, L
   Chimonas, S
   Mao, JJ
AF Li, Xiaotong
   Baser, Raymond E.
   Bryl, Karolina
   Amann, Lindsay
   Chimonas, Susan
   Mao, Jun J.
TI How does pretreatment expectancy influence pain outcomes with
   electroacupuncture and battlefield acupuncture in cancer survivors?
   Pretreatment expectancy and pain reduction by acupuncture
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Article
DE Expectancy; Nonspecific effect; Pain; Electroacupuncture; Battlefield
   acupuncture
ID VALIDATION; PREVALENCE; MANAGEMENT; VERSION; FMRI
AB Background: Outcome expectancy is an important component of non-specific effect that may play an important role in pain research and clinical care. We sought to evaluate whether pretreatment expectancy predicts pain reduction in cancer survivors receiving electroacupuncture (EA) or battlefield acupuncture (BFA). Methods: We analyzed data from a randomized clinical trial that compared EA and BFA versus wait list control (WLC) for chronic musculoskeletal pain in cancer survivors. Expectancy was measured by the Acupuncture Expectancy Scale (AES) at baseline. Pain severity was assessed using the Brief Pain Inventory (BPI) at baseline and week 12. For each treatment arm, multivariable regression models were used to evaluate the association between pretreatment expectancy and week 12 pain severity, controlling for baseline pain severity, age, sex, race, and education. Results: Among 360 participants enrolled, the mean age was 62.1 years (SD 12.7), with 251 (69.7 %) women and 88 (24.4 %) non-white survivors. Pretreatment expectancy was similar for all groups at baseline (EA: 13.9 +/- 3.6; BFA: 13.2 +/- 3.7, WLC:12.8 +/- 3.3, p = 0.14). Greater pretreatment expectancy was not significantly associated with greater pain reduction in any group, after adjusting for co-variates (EA: Coef. = -0.05, 95 % CI = -0.14 - 0.04, p = 0.28; BFA: Coef. = -0.07, 95 % CI = -0.16 - 0.02, p = 0.15; WLC: Coef. = -0.09, 95 % CI = -0.25 - 0.06, p = 0.23). Conclusions: Pretreatment expectancy did not predict pain reduction for either EA or BFA in cancer survivors. Our study contributes to the interpretation of analgesic effects of EA or BFA, beyond the notion of a mere 'placebo effect'.
C1 [Li, Xiaotong; Bryl, Karolina; Amann, Lindsay; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st Str,4th Floor, New York, NY 10065 USA.
   [Baser, Raymond E.; Chimonas, Susan] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.
   [Chimonas, Susan] Mem Sloan Kettering Canc Ctr, Ctr Hlth Policy & Outcomes, New York, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st Str,4th Floor, New York, NY 10065 USA.
EM maoj@mskcc.org
RI Amann, Lindsay/NAX-6943-2025; Bryl, Karolina L/HKW-3833-2023; Li,
   Xiaotong/HTN-2157-2023
OI Bryl, Karolina L/0000-0002-1804-367X; Li, Xiaotong/0000-0003-1006-5871;
   Mao, Jun/0000-0001-9229-0380
FU Department of Defense office of the Congressionally Directed Medical
   Research Programs through the Peer Reviewed Medical Research Program
   Clinical Trial Award [W81XWH-15-1-0245]; National Institutes of
   Health/National Cancer Institute Cancer Center [P30 CA008748]
FX This work was supported by the Department of Defense office of the
   Congressionally Directed Medical Research Programs through the Peer
   Reviewed Medical Research Program Clinical Trial Award
   (W81XWH-15-1-0245) . This work was also supported in part by a National
   Institutes of Health/National Cancer Institute Cancer Center grant (P30
   CA008748) .
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NR 41
TC 2
Z9 2
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD JUN
PY 2024
VL 13
IS 2
AR 101040
DI 10.1016/j.imr.2024.101040
EA APR 2024
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SU9F7
UT WOS:001237071200001
PM 38721341
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yeh, CH
   Lukkahatai, N
   Huang, XR
   Wu, HL
   Wang, HY
   Zhang, JY
   Sun, XY
   Smith, TJ
AF Yeh, Chao Hsing
   Lukkahatai, Nada
   Huang, Xinran
   Wu, Hulin
   Wang, Hongyu
   Zhang, Jingyu
   Sun, Xinyi
   Smith, Thomas J.
TI Biological Correlates of the Effects of Auricular Point Acupressure on
   Pain
SO PAIN MANAGEMENT NURSING
LA English
DT Article
DE Auricular point acupressure; Inflammatory biomarkers; Cytokines;
   Chemokines; Self-management
ID LOW-BACK-PAIN; CANCER SURVIVORS; ACUPUNCTURE; MANAGEMENT; IL-6;
   INHIBITOR; CYTOKINES; SOCIETY
AB Background: To identify candidate inflammatory biomarkers for the underlying mechanism of auricular point acupressure (APA) on pain relief and examine the correlations among pain intensity, interference, and inflammatory biomarkers.Design: This is a secondary data analysis.Methods: Data on inflammatory biomarkers collected via blood samples and patient self-reported pain intensity and interference from three pilot studies (chronic low back pain, n = 61; arthralgia related to aromatase inhibitors, n = 20; and chemotherapy-induced neuropathy, n = 15) were integrated and analyzed. This paper reports the results based on within-subject treatment effects (change in scores from pre-to post-APA intervention) for each study group (chronic low back pain, cancer pain), between-group differences (changes in scores from pre-to post-intervention between targeted-point APA [T-APA] and non-targeted-point APA [NT-APA]), and correlations among pain intensity, interference, and biomarkers. Results: Within-group analysis (the change score from pre-to post-APA) revealed statistically significant changes in three biomarkers: TNF-alpha (cancer pain in the APA group, p = .03), beta-endorphin (back pain in the APA group, p = .04), and IL-2 (back pain in the NT-APA group, p = .002). Based on between-group analysis in patients with chronic low back pain (T-APA vs NT-APA), IL-4 had the largest effect size (0.35), followed by TNF-alpha (0.29). A strong positive monotonic relationship between IL-1 beta and IL-2 was detected.Conclusions: The current findings further support the potential role of inflammatory biomarkers in the analgesic effects of APA. More work is needed to gain a comprehensive understanding of the underlying mechanisms of APA on chronic pain. Because it is simple, inexpensive, and has no negative side effects, APA can be widely disseminated as an alternative to opioids.(c) 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Pain Management Nursing.This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Yeh, Chao Hsing; Wang, Hongyu] Univ Texas Hlth Sci Ctr Houston, Cizik Sch Nursing, Houston, TX USA.
   [Lukkahatai, Nada] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   [Huang, Xinran; Wu, Hulin] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
   [Wang, Hongyu] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Houston, TX USA.
   [Zhang, Jingyu; Sun, Xinyi] Johns Hopkins Univ, Krieger Sch Arts & Sci, Baltimore, MD USA.
   [Smith, Thomas J.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Yeh, Chao Hsing] 6901 Bertner Ave, Houston, TX 77030 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Johns Hopkins University; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; University of Texas System; University of Texas
   Health Science Center Houston; Johns Hopkins University; Johns Hopkins
   University
RP Yeh, CH (corresponding author), 6901 Bertner Ave, Houston, TX 77030 USA.
EM chao.hsing.yeh@uth.tmc.edu
RI Lukkahatai, Nada/GQA-9711-2022; Huang, Xinran/KFB-7757-2024
OI Lukkahatai, Nada/0000-0003-3820-1812; Smith, Thomas/0000-0003-3040-6434;
   Huang, Xinran/0000-0002-8126-9735; Yeh, Chao Hsing/0000-0001-5326-6660
FU National Institute on Aging of the National Institutes of Health
   [R01AG056587]; Under Armour Women's Health & Breast Cancer Innovation
   Grant, Johns Hopkins Medicine; National Institute on Aging [R01AG056587]
   Funding Source: NIH RePORTER
FX Research reported in this publication was supported by grants to Dr.
   Chao Hsing Yeh from Under Armour Women's Health & Breast Cancer
   Innovation Grant, Johns Hopkins Medicine, and the National Institute on
   Aging of the National Institutes of Health (R01AG056587).
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NR 65
TC 15
Z9 18
U1 5
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD FEB
PY 2023
VL 24
IS 1
BP 19
EP 26
DI 10.1016/j.pmn.2022.11.004
EA FEB 2023
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 9P5HV
UT WOS:000944317000001
PM 36543665
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Correia, JS
   Silva, M
   Castro, C
   Miranda, L
   Agrelo, A
AF Correia, Joana Sousa
   Silva, Manuel
   Castro, Clara
   Miranda, Lina
   Agrelo, Ana
TI The efficacy of the ganglion impar block in perineal and pelvic cancer
   pain
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Ganglion impar block; Walters' block; Pelvic cancer pain; Perineal
   cancer pain
ID MANAGEMENT; ANATOMY
AB Background Visceral pain conducted by sympathetic fibers with pelvic and perineal origin can be treated using ganglion impar (GIB) or Walters' block in a simple and effective manner. This article aims to evaluate the effectiveness, security, and performance difficulty of GIB in patients with pelvic and perineal oncological pain. Methods A retrospective study between January 2016 and August 2017. Patients with poorly controlled pelvic oncological pain and patients experimenting opioid side effects in which GIB was performed ambulatory were included. Prognostic GIB was performed, under echographic and fluoroscopic control, with local anesthetic and corticoid. The neurolytic block was performed under fluoroscopic guidance. The technique was performed by the same anesthetist with pain management competence. For statistical analysis, Microsoft Excel 2013 (R) and IBM SPSS Statistics version 22.0 were used. Results Fifteen patients were included. One patient was excluded. A statistical significant basal pain score reduction was observed ((median of the verbal numerical scale (VNS) 7 (p25 = 7; p75 = 8)) compared with 72 h median VNS 4 ((p25 = 3; p75 = 5.3) p = 0.001, and 3 months (median VNS 4 (p25 = 3, p75 = 7)) p = 0.003 after the procedure. Regarding morphine consumption, a statistically significant reduction was observed 3 months after GIB performance (p = 0.012). Discussion/conclusion GIB is a safe and easy-to-perform technique achieving satisfactory and statistically significant results, regarding pain control improvement and opioid consumption reduction in patients which meet selection criteria. Prospective, randomized studies with more patients are needed for further conclusions.
C1 [Correia, Joana Sousa; Silva, Manuel; Miranda, Lina; Agrelo, Ana] Inst Portugues Oncol Porto Francisco Gentil, Dept Anesthesiol, Porto, Portugal.
   [Castro, Clara] Inst Portugues Oncol Porto Francisco Gentil, Dept Clin Epidemiol, Porto, Portugal.
   [Agrelo, Ana] Inst Portugues Oncol Porto Francisco Gentil, Pain Study & Treatment Dept, Porto, Portugal.
RP Correia, JS (corresponding author), Inst Portugues Oncol Porto Francisco Gentil, Dept Anesthesiol, Porto, Portugal.
EM joanassousacorreia@gmail.com
RI Agrelo, Ana/H-6410-2015; Castro, Clara/M-4779-2013
OI Castro, Clara/0000-0001-9653-4581
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NR 21
TC 17
Z9 19
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD NOV
PY 2019
VL 27
IS 11
BP 4327
EP 4330
DI 10.1007/s00520-019-04738-9
PG 4
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA JF6CZ
UT WOS:000491476800035
PM 30880371
DA 2026-01-16
ER

PT J
AU Latchman, J
   Le, LQ
   McGuire, A
AF Latchman, Jessica
   Le, Liem Q.
   McGuire, Anthony
TI Incorporating Music Therapy With Acupuncture in Managing Cancer Pain at
   an Acupuncture Practice
SO CLINICAL JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
ID MANAGEMENT; SCORES
AB BACKGROUND: Complementary and alternative medicine encompasses various nonpharmacologic interventions for managing pain, such as acupuncture and music therapy. Few studies have combined these two interventions in the management of cancer -related pain. OBJECTIVES: The purpose of this evidence -based project was to compare acupuncture -only therapy versus dual therapy (acupuncture and music therapy) on pain intensity scores in patients with cancer. METHODS: This evidence -based project included 102 participants at a private acupuncture practice. One group had acupuncture only for six weeks, and another had six weeks of acupuncture and music therapy. The Numeric Pain Rating Scale was used to assess pain before and after the interventions. FINDINGS: Findings showed that both groups had clinically and statistically significant improvements in pain intensity scores. Although a significant difference was not noted between the two groups, acupuncture and music therapy were each found to be effective for managing cancer -related pain.
C1 [Latchman, Jessica; Le, Liem Q.] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
   [Le, Liem Q.] Univ Western States, Human Nutr & Funct Med Dept, Portland, OR USA.
   [McGuire, Anthony] Univ S Florida, Coll Nursing, Tampa, FL USA.
C3 H Lee Moffitt Cancer Center & Research Institute; State University
   System of Florida; University of South Florida
RP Latchman, J (corresponding author), H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
EM atjessica.latchman@moffitt.org
RI McGuire, Anthony/HQY-4372-2023
FX The authors gratefully acknowledge ErnestAmankwah, PhD, and
   CindyTofthagen, PhD, APRN, AOCNP (R) , FAANP, FAAN, for their invaluable
   time, insight, and advice on this project.
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NR 24
TC 1
Z9 1
U1 1
U2 11
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 1092-1095
EI 1538-067X
J9 CLIN J ONCOL NURS
JI Clin. J. Oncol. Nurs.
PD JUN
PY 2024
VL 28
IS 3
BP 305
EP 312
DI 10.1188/24.CJON.305-312
PG 8
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA XH5Y3
UT WOS:001260816600012
PM 38830247
DA 2026-01-16
ER

PT J
AU Zhang, JL
   Qin, ZS
   So, TH
   Chang, TY
   Yang, SC
   Chen, HY
   Yeung, WF
   Chung, KF
   Chan, PY
   Huang, Y
   Xu, SF
   Chiang, CY
   Lao, LX
   Zhang, ZJ
AF Zhang, Jialing
   Qin, Zongshi
   So, Tsz Him
   Chang, Tien Yee
   Yang, Sichang
   Chen, Haiyong
   Yeung, Wing Fai
   Chung, Ka Fai
   Chan, Pui Yan
   Huang, Yong
   Xu, Shifen
   Chiang, Chun Yuan
   Lao, Lixing
   Zhang, Zhang-Jin
TI Acupuncture for chemotherapy-associated insomnia in breast cancer
   patients: an assessor-participant blinded, randomized, sham-controlled
   trial
SO BREAST CANCER RESEARCH
LA English
DT Article
DE Chemotherapy-associated insomnia; Breast cancer; Acupuncture; Cessation
   rate of sleeping medications
ID COGNITIVE-BEHAVIORAL THERAPY; SLEEP QUALITY INDEX; CHINESE VERSION;
   INTEGRATIVE MEDICINE; BENZODIAZEPINE USE; HOSPITAL ANXIETY; SEVERITY
   INDEX; FACT-B; VALIDATION; DEPRESSION
AB Background Insomnia is a highly prevalent symptom occurred during and post-chemotherapy. Acupuncture may have beneficial effects in the management of chemotherapy-associated insomnia. This study was conducted to determine the efficacy and safety of acupuncture in improving chemotherapy-associated insomnia in breast cancer patients.Methods This assessor-participant blinded, randomized, sham-controlled trial was conducted from November 2019 to January 2022 (follow-up completed July 2022). Participants were referred by oncologists from two Hong Kong hospitals. Assessments and interventions were conducted at the outpatient clinic of School of Chinese Medicine, the University of Hong Kong. The 138 breast cancer patients with chemotherapy-associated insomnia were randomly assigned to receive either 15 sessions of active acupuncture regimen by combining needling into body acupoints and acupressure on auricular acupoints or sham acupuncture control (69 each) for 18 weeks, followed by 24 weeks of follow-up. The primary outcome was measured using Insomnia Severity Index (ISI). Secondary outcomes included the Pittsburgh Sleep Quality Index, Actiwatch and sleep diary for sleep parameters, depression and anxiety, fatigue and pain, and quality of life.Results There were 87.7% (121/138) participants who completed the primary endpoint (week-6). The active acupuncture regimen was not superior to the sham control in reducing ISI score from baseline to 6 weeks (mean difference: - 0.4, 95% CI - 1.8-1.1; P = 0.609), but produced short-term treatment and long-term follow-up better outcomes in improving sleep onset latency, total sleep time, sleep efficiency, anxiety, depression, and quality of life. Participants of the active acupuncture group had a pronouncedly higher cessation rate of sleeping medications than the sham control (56.5% vs. 14.3%, P = 0.011). All treatment-related adverse events were mild. No participants discontinued treatments due to adverse events.Conclusion The active acupuncture regimen could be considered as an effective option for the management of chemotherapy-associated insomnia. It also could serve as a tapering approach to reduce and even replace the use of sleeping medications in breast cancer patients.
C1 [Zhang, Jialing; Qin, Zongshi; Yang, Sichang; Chen, Haiyong; Chan, Pui Yan; Lao, Lixing; Zhang, Zhang-Jin] Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.
   [Zhang, Jialing] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China.
   [So, Tsz Him] Univ Hong Kong, LKS Fac Med, Dept Clin Oncol, Pokfulam, Hong Kong, Peoples R China.
   [Chang, Tien Yee] Hong Kong Sanat & Hosp, Comprehens Oncol Ctr, Hong Kong, Peoples R China.
   [Yeung, Wing Fai] Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Hong Kong, Peoples R China.
   [Chung, Ka Fai] Univ Hong Kong, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China.
   [Huang, Yong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Xu, Shifen] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China.
   [Chiang, Chun Yuan] Hong Kong Inst Cell & Mol Med, Hong Kong, Peoples R China.
   [Chiang, Chun Yuan] Digital Ctr, State Key Lab Qual Appraisal TCM, Hong Kong, Peoples R China.
   [Lao, Lixing] Virginia Univ Integrat Med, Fairfax, VA 22031 USA.
   [Zhang, Zhang-Jin] Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp HKU SZH, Shenzhen 518053, Guangdong, Peoples R China.
C3 University of Hong Kong; Hong Kong Baptist University; University of
   Hong Kong; Hong Kong Polytechnic University; University of Hong Kong;
   Southern Medical University - China; Shanghai University of Traditional
   Chinese Medicine; University of Hong Kong
RP Lao, LX; Zhang, ZJ (corresponding author), Univ Hong Kong, LKS Fac Med, Sch Chinese Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.; Lao, LX (corresponding author), Virginia Univ Integrat Med, Fairfax, VA 22031 USA.; Zhang, ZJ (corresponding author), Univ Hong Kong, Dept Chinese Med, Shenzhen Hosp HKU SZH, Shenzhen 518053, Guangdong, Peoples R China.
EM llao@vuim.edu; zhangzj@hku.hk
RI CHEN, Haiyong/G-6787-2014; Qin, Zongshi/ABE-2821-2021; ZHANG,
   Jialing/IAN-2737-2023; Yeung, Wing-Fai/E-7971-2013; Lao,
   Lixing/P-9107-2019; So, Tsz-him/U-1240-2019; ZHANG,
   ZHANG-JIN/ORK-0709-2025
OI CHEN, Haiyong/0000-0002-4889-2752; Qin, Zongshi/0000-0001-5888-461X;
   ZHANG, Jialing/0000-0003-0900-4617; 
FU Health and Medical Research Fund, Government of the Hong Kong Special
   Administrative Region of China [16172761]
FX This trial was funded by Health and Medical Research Fund, Government of
   the Hong Kong Special Administrative Region of China (Ref no:16172761).
   The funding body was not involved in study design and conduct, data
   collection, management, analysis and interpretation.
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NR 75
TC 48
Z9 56
U1 11
U2 62
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1465-5411
EI 1465-542X
J9 BREAST CANCER RES
JI Breast Cancer Res.
PD APR 26
PY 2023
VL 25
IS 1
AR 49
DI 10.1186/s13058-023-01645-0
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA I4TP5
UT WOS:001002724400002
PM 37101228
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, XY
   Chung, VCH
   Hui, EP
   Ziea, ETC
   Ng, BFL
   Ho , RST
   Tsoi, KKF
   Wong, SYS
   Wu, JCY
AF Wu, Xinyin
   Chung, Vincent C. H.
   Hui, Edwin P.
   Ziea, Eric T. C.
   Ng, Bacon F. L.
   Ho, Robin S. T.
   Tsoi, Kelvin K. F.
   Wong, Samuel Y. S.
   Wu, Justin C. Y.
TI Effectiveness of acupuncture and related therapies for palliative care
   of cancer: overview of systematic reviews
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SEARCH STRATEGIES; HOT FLASHES; METAANALYSES; MANAGEMENT; SAFETY; PAIN;
   INTERVENTIONS; MOXIBUSTION; FATIGUE; QUALITY
AB Acupuncture and related therapies such as moxibustion and transcutaneous electrical nerve stimulation are often used to manage cancer-related symptoms, but their effectiveness and safety are controversial. We conducted this overview to summarise the evidence on acupuncture for palliative care of cancer. Our systematic review synthesised the results from clinical trials of patients with any type of cancer. The methodological quality of the 23 systematic reviews in this overview, assessed using the Methodological Quality of Systematic Reviews Instrument, was found to be satisfactory. There is evidence for the therapeutic effects of acupuncture for the management of cancer-related fatigue, chemotherapy-induced nausea and vomiting and leucopenia in patients with cancer. There is conflicting evidence regarding the treatment of cancer-related pain, hot flashes and hiccups, and improving patients' quality of life. The available evidence is currently insufficient to support or refute the potential of acupuncture and related therapies in the management of xerostomia, dyspnea and lymphedema and in the improvement of psychological well-being. No serious adverse effects were reported in any study. Because acupuncture appears to be relatively safe, it could be considered as a complementary form of palliative care for cancer, especially for clinical problems for which conventional care options are limited.
C1 [Wu, Xinyin; Chung, Vincent C. H.; Hui, Edwin P.; Wong, Samuel Y. S.; Wu, Justin C. Y.] Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Hong Kong, Hong Kong, Peoples R China.
   [Wu, Xinyin; Chung, Vincent C. H.; Ho, Robin S. T.; Tsoi, Kelvin K. F.; Wong, Samuel Y. S.] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.
   [Hui, Edwin P.] Chinese Univ Hong Kong, Comprehens Canc Trials Unit, Hong Kong, Hong Kong, Peoples R China.
   [Ziea, Eric T. C.; Ng, Bacon F. L.] Hong Kong Hosp Author, Chinese Med Dept, Hong Kong, Hong Kong, Peoples R China.
   [Tsoi, Kelvin K. F.] Chinese Univ Hong Kong, Big Data Decis Analyt Res Ctr, Hong Kong, Hong Kong, Peoples R China.
   [Wu, Justin C. Y.] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Chung, VCH (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Hong Kong, Hong Kong, Peoples R China.
EM vchung@cuhk.edu.hk
RI Ng, Bacon/I-5554-2013; Wu, Justin/N-6916-2015; Hui, Edwin/ABC-1818-2021;
   Chung, Vincent/K-2447-2013; WONG, Samuel/D-7311-2013
FU Hospital Authority of Hong Kong [8110016609]
FX This study was funded by Hospital Authority of Hong Kong (Reference
   number: 8110016609).
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NR 55
TC 59
Z9 60
U1 0
U2 60
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 26
PY 2015
VL 5
AR 16776
DI 10.1038/srep16776
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CX0JJ
UT WOS:000365382400001
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Katta, MR
   Valisekka, SS
   Agarwal, P
   Hameed, M
   Shivam, S
   Kaur, J
   Prasad, S
   Bethineedi, LD
   Lavu, DV
   Katamreddy, Y
AF Katta, Maanya Rajasree
   Valisekka, Sai Sudha
   Agarwal, Pahel
   Hameed, Maha
   Shivam, Swadha
   Kaur, Jasneet
   Prasad, Sakshi
   Bethineedi, Lakshmi Deepak
   Lavu, Diti Vinuthna
   Katamreddy, Yamini
TI Non-pharmacological integrative therapies for chronic cancer pain
SO JOURNAL OF ONCOLOGY PHARMACY PRACTICE
LA English
DT Review
DE Chronic cancer pain; non-pharmacological; patient education; physical
   therapy; psychosocial therapy
ID QUALITY-OF-LIFE; PALLIATIVE CARE; PATIENT EDUCATION; STRESS REDUCTION;
   PHYSICAL-THERAPY; MANAGEMENT; INTERVENTIONS; ACUPUNCTURE; MINDFULNESS;
   COMPLEMENTARY
AB Objective Chronic pain is one of the most detrimental symptoms exhibited by cancer patients, being an indication for opioid therapy in up to half of the patients' receiving chemotherapy and in 90% of advanced cases. Various successful non-pharmacological integrative therapy options have been explored and implemented to improve the quality of life in these patients. This review aims to highlight the mechanisms implicated; assessment tools used for cancer pain and summarize current evidence on non-pharmacological approaches in the treatment of chronic cancer pain. Data sources A review of the literature was conducted using a combination of MeSH keywords including "Chronic cancer pain," "Assessment," "Non-pharmacological management," and "Integrative therapy." Data summary Data on the approach and assessment of chronic cancer pain as well as non-pharmacological integrative options have been displayed with the help of figures and tables. Of note, non-pharmacological integrative management was divided into three subcategories; physical therapy (involving exercise, acupuncture, massage, and transcutaneous electric nerve stimulation), psychosocial therapy (e.g. mindful practices, supportive therapy), and herbal supplementation. Conclusions The use of non-pharmacological integrative therapy in the management of chronic cancer pain has been grossly underestimated and must be considered before or as an adjuvant of other treatment regimens to ensure appropriate care.
C1 [Katta, Maanya Rajasree] Gandhi Med Coll, Hyderabad, Telangana, India.
   [Valisekka, Sai Sudha] Sri Venkateshwara Med Coll, Tirupati, Andhra Pradesh, India.
   [Agarwal, Pahel; Shivam, Swadha] Bhaskar Med Coll, Hyderabad, Telangana, India.
   [Hameed, Maha] AlFaisal Univ, Coll Med, Takhassusi St,Al Zahrawi St, Riyadh 11533, Saudi Arabia.
   [Kaur, Jasneet] Govt Med Coll, Amritsar, Punjab, India.
   [Prasad, Sakshi] Natl Pirogov Mem Med Univ, Fac Med, Vinnytsya, Ukraine.
   [Bethineedi, Lakshmi Deepak] Andhra Med Coll, Visakhapatnam, Andhra Pradesh, India.
   [Lavu, Diti Vinuthna] Siddhartha Med Coll, Vijayawada, AP, India.
   [Katamreddy, Yamini] West Anaheim Med Ctr, Anaheim, CA USA.
C3 Gandhi Medical College & Hospital, Hyderabad; National Pirogov Memorial
   Medical University Vinnytsya; Andhra Medical College
RP Hameed, M (corresponding author), AlFaisal Univ, Coll Med, Takhassusi St,Al Zahrawi St, Riyadh 11533, Saudi Arabia.
EM mwhameed2016@gmail.com
RI ; Prasad, Sakshi/AGD-8006-2022; Hameed, Maha/CAF-2061-2022
OI Katta, Maanya Rajasree/0000-0002-8476-3667; Bethineedi, Lakshmi
   Deepak/0000-0003-3637-3768; Hameed, Maha/0000-0001-8066-4584; Kaur,
   Jasneet/0000-0003-0999-1800; Valisekka, Sai Sudha/0000-0001-8744-3899
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NR 75
TC 10
Z9 14
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1078-1552
EI 1477-092X
J9 J ONCOL PHARM PRACT
JI J. Oncol. Pharm. Pract.
PD DEC
PY 2022
VL 28
IS 8
BP 1859
EP 1868
AR 10781552221098437
DI 10.1177/10781552221098437
EA MAY 2022
PG 10
WC Oncology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pharmacology & Pharmacy
GA 5U4HK
UT WOS:000797677600001
PM 35532081
DA 2026-01-16
ER

PT J
AU Huang, L
   Zhao, YQ
   Xiang, MH
AF Huang, Li
   Zhao, Yanqing
   Xiang, Minhong
TI Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric
   Analysis (2000-2019)
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE knowledge mapping; acupuncture; cancer pain; CiteSpace; scientometric
   analysis
ID INDUCED PERIPHERAL NEUROPATHY; CHEMOTHERAPY-INDUCED NAUSEA; STRESS
   REDUCTION PROGRAM; QUALITY-OF-LIFE; BREAST-CANCER; ALTERNATIVE MEDICINE;
   CONTROLLED-TRIAL; JOINT SYMPTOMS; CLINICAL-TRIAL; MANAGEMENT
AB Objective: This study aimed to demonstrate the state of the present situation and trends concerning the global use of acupuncture for cancer pain in the past 20 years.
   Methods: Searched the Web of Science database from 2000 to 2019 related to acupuncture for cancer pain, and then used CiteSpace to conduct scientometric analysis to acquire the knowledge mapping.
   Results: Yearly output has increased year by year, and the growth rate has become faster after 2012. According to the cluster analysis of institutions, authors, cited references, and keywords, 4, 4, 15, and 14 categories were obtained, respectively. The most productive countries, institutions, and authors are the USA, Mem Sloan Kettering Cancer Center, and Mao JJ, whose frequencies are 196, 24, and 17, respectively. However, the most important of them are Australia, Univ. Maryland, and Bao T, owing to their highest centrality, they are 0.90, 0.21, and 0.09 separately. Moreover, cited references that contributed to the most cocitations are Crew KD (2010), however, the most key cited reference is Roscoe JA (2003). Keywords such as acupuncture, pain, breast cancer, palliative care, and quality of life are the most frequently used. But auricular acupuncture is the crucial keyword. In the cluster analysis of institutions, authors, cited references, and keywords, the more convincing research categories are multiple myeloma, placebo effect, neck malignancies, and early breast cancer, with S values of 0.990, 0.991, 0.990, and 0.923, respectively. Therefore, they can be regarded as research hotspots in this field.
   Conclusion: Based on the scientometric analysis in the past 20 years, the knowledge mapping of the country, institution, author, cited reference, and the keyword is gained, which has an important guiding significance for quickly and accurately positioning the trend in this field.
C1 [Huang, Li; Zhao, Yanqing; Xiang, Minhong] Shanghai Univ Tradit Chinese Med, Putuo Hosp, 164 Lanxi Rd, Shanghai 200062, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Xiang, MH (corresponding author), Shanghai Univ Tradit Chinese Med, Putuo Hosp, 164 Lanxi Rd, Shanghai 200062, Peoples R China.
EM xiangminhong1977@126.com
OI zhao, yanqing/0000-0003-4003-0063
FU National Natural Science Foundation of China [82,074,495]; Shanghai
   University of Chinese Medicine [2019WK118]; Scientific Research Project
   of Putuo Hospital, Shanghai University of Traditional Chinese Medicine
   [2020304A]
FX This study was supported by grants from the National Natural Science
   Foundation of China (no. 82,074,495), Budget Project of Shanghai
   University of Chinese Medicine (no. 2019WK118), and Scientific Research
   Project of Putuo Hospital, Shanghai University of Traditional Chinese
   Medicine (No.2020304A).
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NR 82
TC 9
Z9 11
U1 1
U2 32
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2021
VL 14
BP 343
EP 358
DI 10.2147/JPR.S292657
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA QI1PN
UT WOS:000618745500001
PM 33574698
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhao, Q
   Zheng, SY
   Delaney, GP
   Moylan, E
   Agar, MR
   Koh, ES
   Lai, HZ
   Birling, Y
   Zhang, GS
   Wang, K
   Ma, Y
   Zhu, XS
AF Zhao, Qi
   Zheng, Suyang
   Delaney, Geoff P.
   Moylan, Eugene
   Agar, Meera R.
   Koh, Eng-Siew
   Lai, Hezheng
   Birling, Yoann
   Zhang, George Shengxi
   Wang, Kang
   Ma, Yong
   Zhu, Xiaoshu
TI Acupuncture for Cancer Related Pain: Protocol for a Pragmatic Randomised
   Wait-List Controlled Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; cancer related pain; pragmatic; clinical trial;
   complementary and alternative medicine
AB Background:
   Acupuncture has been proved effective for cancer related pain (CRP) in China, America and some other countries. However, there is relative lack of evidence to support the use of acupuncture for CRP in Australia.
   Objectives:
   To assess the effectiveness and safety of acupuncture for management of CRP in a real-world setting and to understand cancer patients' experience of undergoing acupuncture for CRP.
   Methods:
   A pragmatic randomised controlled trial will be conducted in South Western Sydney Local Health District (SWSLHD) in NSW, Australia. Adults with cancer related pain (n = 106) will be randomised in a 1:1 ratio to receive the acupuncture intervention up front versus after a wait list period of 4 weeks. Pain level (by Numerical Rating Scale), analgesic use, auricular acupressure frequency and adverse events will be assessed at baseline, mid-treatment and post-treatment. Expectancy on trial outcome (by Credibility and Expectancy questionnaire) will be assessed at baseline. The perspective of the participants (by an interview) will be recorded after the last intervention.
   Expected outcomes:
   We hypothesise that acupuncture will relieve cancer related pain at mid-treatment and post-treatment. We also hypothesise that few adverse events will be provoked by acupuncture.
C1 [Zhao, Qi; Wang, Kang] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China.
   [Zhao, Qi; Zheng, Suyang; Lai, Hezheng; Birling, Yoann; Zhang, George Shengxi; Wang, Kang; Zhu, Xiaoshu] Western Sydney Univ, Chinese Med Ctr, Locked Bag 1797, Penrith, NSW 2751, Australia.
   [Zheng, Suyang; Ma, Yong] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
   [Delaney, Geoff P.; Agar, Meera R.] Univ NSW, Sydney, NSW, Australia.
   [Moylan, Eugene; Agar, Meera R.; Koh, Eng-Siew] South Western Sydney Local Hlth Dist, Sydney, NSW, Australia.
   [Agar, Meera R.] Univ Technol Sydney, Sydney, NSW, Australia.
   [Ma, Yong] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China.
C3 Beijing University of Chinese Medicine; Western Sydney University;
   Nanjing University of Chinese Medicine; University of New South Wales
   Sydney; South Western Sydney Local Health District; University of
   Technology Sydney; Nanjing University of Chinese Medicine
RP Zhu, XS (corresponding author), Western Sydney Univ, Chinese Med Ctr, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM X.Zhu@westernsydney.edu.au
RI Agar, Meera/AAI-4002-2021; Zhu, Xiaoshu/NRX-7991-2025; Zheng,
   Suyang/HNR-6545-2023; Birling, Yoann/AAA-8437-2022; Zhao,
   Qi/AAS-8810-2021
OI Agar, Meera/0000-0002-6756-6119; Zhu, Xiaoshu/0000-0002-2909-5926;
   Zheng, Suyang/0000-0001-8517-6002; Delaney, Geoff/0000-0002-1829-396X; 
FU China Scholarship Council; Postgraduate Research & Practice Innovation
   Program of Jiangsu Province [KYCX19_1200]
FX The authors would like to thank Ling Fu, Pengli Wang, Feifei Zhang for
   their literature review work, Jie Hao for her amendment for protocol,
   Jessica Grundy and Andrea Lee for their comments on the protocol. Suyang
   Zheng is supported by China Scholarship Council and Postgraduate
   Research & Practice Innovation Program of Jiangsu Province
   (KYCX19_1200).
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NR 59
TC 3
Z9 3
U1 1
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD DEC
PY 2020
VL 19
AR 1534735420976579
DI 10.1177/1534735420976579
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA PE9LE
UT WOS:000598681100001
PM 33300382
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Induru, RR
   Lagman, RL
AF Induru, Raghava R.
   Lagman, Ruth L.
TI Managing cancer pain: Frequently asked questions
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Article
ID ALTERNATIVE MEDICINE USE; OPIOID THERAPY; COMPLEMENTARY/ALTERNATIVE
   MEDICINE; ADJUVANT ANALGESICS; CONTROLLED-TRIAL; PRIMARY-CARE;
   MANAGEMENT; ACUPUNCTURE; RELIABILITY; VALIDITY
AB For a variety of reasons, cancer pain is often undertreated, adversely affecting the quality of life for patients and caregivers. To manage cancer pain effectively, physicians need to understand its pathogenesis, how to assess it, how to treat it, and, in particular, how to optimize opioid treatment. We discuss common questions faced by physicians in everyday practice.
C1 [Induru, Raghava R.; Lagman, Ruth L.] Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Lagman, RL (corresponding author), Cleveland Clin, Taussig Canc Ctr, R35,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM lagmanr@ccf.org
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NR 63
TC 15
Z9 17
U1 1
U2 5
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD JUL
PY 2011
VL 78
IS 7
BP 449
EP +
DI 10.3949/ccjm.78a.10054
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 793XV
UT WOS:000292858100004
PM 21724928
OA Bronze
DA 2026-01-16
ER

PT J
AU Utli, H
   Dinç, M
   Utli, A
AF Utli, Hediye
   Dinc, Mahmut
   Utli, Adil
TI The effect of acupressure or reiki interventions on the levels of pain
   and fatigue of cancer patients receiving palliative care: A randomized
   controlled study
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Acupressure; Analgesic use; Cancer pain; Fatigue; Palliative care; Reiki
ID QUALITY-OF-LIFE; THERAPY; MANAGEMENT; ONCOLOGY; CHEMOTHERAPY; TRIAL;
   WOMEN
AB Objective: Taking pain under control is important to calm the individual and reduce complications. This research was conducted with the aim of determining the effect of Acupressure or Reiki interventions on the levels of pain and fatigue of stage III and IV cancer patients receiving palliative care. Method: The research was a single-blind, repeated measures, randomized controlled study. Research data were collected between February and November 2022. The research sample consisted of Acupressure and Reiki intervention groups and a control group with 52 patients in each group for a total of 156 patients. Acupressure or Reiki was applied to their intervention groups for a total of eight sessions of 20 min each over four weeks, once a day on two days a week. Data were collected by means of a patient description form, an analgesic follow-up form, the Numeric Pain Rating Scale, and the Brief Fatigue Inventory. Results: In comparison with the control group, a significant reduction was seen over time in the levels of pain (p < 0.001), analgesic use (p < 0.001), and fatigue (p < 0.001) in the Acupressure or Reiki intervention groups. Conclusion: Acupressure or Reiki interventions were found to effective in reducing levels of pain, analgesic use, and fatigue. It was seen that in addition to their use in routine nursing care, both treatments can be accepted as effective nursing interventions that reduce pain and fatigue in stage III and IV cancer patients receiving palliative care.
C1 [Utli, Hediye] Mardin Artuklu Univ, Vocat Sch Hlth Serv, Dept Elderly Care, Mardin, Turkiye.
   [Dinc, Mahmut] Batman Univ, Fac Hlth Sci, Dept Nursing, Batman, Turkiye.
   [Utli, Adil] Eskisehir Osmangazi Fac Med, Dept Emergency Med, Eskisehir, Turkiye.
C3 Mardin Artuklu University; Batman University
RP Utli, H (corresponding author), Artuklu Campus,Box 47110, Mardin, Turkiye.
EM hediyeutli@artuklu.edu.tr
RI ; Utli Özbay, Hediye/HKN-6303-2023
OI Utli Özbay, Hediye/0000-0002-4732-9503; 
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NR 41
TC 13
Z9 17
U1 3
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD JAN-FEB
PY 2023
VL 19
IS 1
BP 91
EP 99
DI 10.1016/j.explore.2022.11.007
EA JAN 2023
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 9Z7DH
UT WOS:000951296900001
PM 36476354
DA 2026-01-16
ER

PT J
AU Butkovic, D
   Tot, OK
AF Butkovic, D.
   Tot, O. K.
TI Laser acupuncture treatment of neuropathic pain in a boy with brain
   tumour
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Laser acupuncture; Neuropathic pain; Paediatric; Brain tumour; Linezolid
ID INDUCED PERIPHERAL NEUROPATHY; THERAPY
AB Neuropathic pain occurrence is associated with some cytostatic and antibiotics use. Pharmacological therapy for the treatment of neuropathic pain is sometimes unsuccessful, and complementary methods like acupuncture are included. In this case report, a 14-year-old boy with cerebral tumour and neuropathic pain in his feet after chemotherapy and linezolid use is presented. A complete cessation of neuropathic pain symptoms like hyperalgesia and allodynia was accomplished after laser acupuncture application.
C1 [Butkovic, D.; Tot, O. K.] Univ Osijek, Sch Med, Osijek, Croatia.
   [Butkovic, D.] Childrens Hosp Zagreb, Paediat Pain Clin, Zagreb, Croatia.
   [Tot, O. K.] Clin Hosp Ctr Osijek, Dept Pain Therapy, Osijek, Croatia.
C3 University of JJ Strossmayer Osijek; University of Zagreb; University of
   Zagreb Hospital
RP Butkovic, D (corresponding author), Childrens Hosp Zagreb, Dept Anaesthesiol Reanimat & Intens Care, Klaiceva 16, Zagreb 10000, Croatia.
EM diana.butkovic1@gmail.com
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NR 17
TC 3
Z9 4
U1 0
U2 14
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD DEC
PY 2017
VL 35
BP 53
EP 56
DI 10.1016/j.ctim.2017.09.006
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FQ2XR
UT WOS:000418221800010
PM 29154067
DA 2026-01-16
ER

PT J
AU Zhang, RY
   Zhu, BF
   Wang, LK
   Song, Y
   Zhao, JG
   Guo, Y
   Zhao, L
   Chen, S
AF Zhang, Rong yi
   Zhu, Ben Fan
   Wang, Li kui
   Song, Yang
   Zhao, Jia Gui
   Guo, Yan
   Zhao, Long
   Chen, Shi
TI Electroacupuncture alleviates inflammatory pain via adenosine
   suppression and its mediated substance P expression
SO ARQUIVOS DE NEURO-PSIQUIATRIA
LA English
DT Article
DE Electroacu puncture; Chronic Pain; Adenosine; Substance P
ID ADENOSINE-A1-RECEPTORS MEDIATE; HYPERALGESIA; RECEPTORS; OPIOIDS; ALPHA;
   MICE
AB Background: Acupuncture has been widely used for alleviating pain. However, its mechanisms remain largely enigmatic. Objective: In the present study, we focused on whether the analgesic effect of electroacupuncture is related to its regulation on adenosine and substance P expression. Methods: We established chronic inflammatory pain model in rats through a single injection of Complete Freund's Adjuvant, and then we treated animals using dailyelectroacupuncture.We applied seven bilateralsessions of electroacu puncture (ST36 and BL60, 0.5 to 1.5 mA, initialstrength of 0.5 mA, increased by 0.5 mA every 10 minutes, for 30 minutes per session, one section per day) to Complete Freund's Adjuvant rats for seven days. The analgesic effect of electroacupuncture was evaluated by measuring paw withdrawal threshold in rats that received mechanical and thermal stimulation. Results: Daily electroacupuncture stimulation effectively increased paw withdrawal threshold in Complete Freund's Adjuvant rats. Electroacupuncture increased the adenosine level in zusanli.Afurtherstudyshowed that electroacu puncture could decrease substance P, neurokinin-1 receptor,tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and CD68 levels in dorsal root ganglion. Interestingly, direct injection of adenosine A1 or substance P receptor antagonists, or dorsal nerve root transection could significantly impair electroacupuncture induced analgesic actions in Complete Freund's Adjuvant rats could and reduce the levels of substance P neurokinin-1 receptor, tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and CD68. Finally, we confirmed that direct injection of adenosine A1 receptor agonist replicated the analgesic effect of electroacupuncture. Conclusion: Our results indicate regulation of adenosine-mediated substance Psecretion.Substance P-mediated pathway may be involved in the analgesia process by electroacupuncture in rats.
C1 [Zhang, Rong yi; Zhu, Ben Fan; Wang, Li kui; Song, Yang; Zhao, Jia Gui; Guo, Yan; Zhao, Long; Chen, Shi] Anhui Med Univ, Affiliated Hosp 1, Dept Pain Management, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University
RP Zhang, RY (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Pain Management, Hefei, Anhui, Peoples R China.
EM rongyizha@163.com
RI ; yang, song/GVU-7963-2022
OI , 赵龙/0000-0002-2209-2810; 
FU National Natural Science Foundation of Anhui province [1808085MH310];
   Grants of the Scientific Research of BoshiKeYan (BSKY) from the First
   Affiliated Hospital of Anhui Medical University [3101005001249]
FX This work was supported by the National Natural Science Foundation of
   Anhui province (No. 1808085MH310) and by Grants of the Scientific
   Research of BoshiKeYan (BSKY) (No. 3101005001249) from the First
   Affiliated Hospital of Anhui Medical University.
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NR 26
TC 27
Z9 30
U1 2
U2 12
PU ASSOC ARQUIVOS NEURO- PSIQUIATRIA
PI SAO PAULO SP
PA PR AMADEU AMARAL 47/33, 01327-010 SAO PAULO SP, BRAZIL
SN 0004-282X
EI 1678-4227
J9 ARQ NEURO-PSIQUIAT
JI Arq. Neuro-Psiquiatr.
PD OCT
PY 2020
VL 78
IS 10
BP 617
EP 623
DI 10.1590/0004-282X20200078
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA OR2AN
UT WOS:000589277400004
PM 33146290
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Glickman-Simon, R
   Lindsay, T
AF Glickman-Simon, Richard
   Lindsay, Tammy
TI CANNABINOIDS FOR CHRONIC PAIN, MEDITERRANEAN DIET AND COGNITIVE
   FUNCTION; VITAMIN E AND SELENIUM FOR CATARACT PREVENTION; ACUPUNCTURE
   AND MOXIBUSTION FOR PRIMARY DYSMENORRHEA; MASSAGE THERAPY AND IN VITRO
   FERTILIZATION
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Editorial Material
ID AGE-RELATED CATARACT; RANDOMIZED CLINICAL-TRIAL; SENILE CATARACT;
   METAANALYSIS; SUPPLEMENTATION; DISEASE; CANCER; WOMEN; LENS; MEN
C1 [Glickman-Simon, Richard] Tufts Univ, Sch Med, Publ Hlth & family Med, Boston, MA 02111 USA.
   [Lindsay, Tammy] Missouri Highlands Hlth Care, Ellington, CO 63638 USA.
C3 Tufts University
RP Glickman-Simon, R (corresponding author), Tufts Univ, Sch Med, Publ Hlth & family Med, Boston, MA 02111 USA.
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NR 43
TC 4
Z9 7
U1 0
U2 38
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD NOV-DEC
PY 2015
VL 11
IS 6
BP 489
EP 493
DI 10.1016/j.explore.2015.08.013
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CY1DI
UT WOS:000366146500015
PM 26525669
DA 2026-01-16
ER

PT J
AU Yeh, CH
   Lin, WC
   Suen, LKP
   Park, NJ
   Wood, LJ
   van Londen, GJ
   Bovbjerg, DH
AF Yeh, Chao Hsing
   Lin, Wei-Chun
   Suen, Lorna Kwai-Ping
   Park, Na-Jin
   Wood, Lisa J.
   van Londen, G. J.
   Bovbjerg, Dana Howard
TI Auricular Point Acupressure to Manage Aromatase Inhibitor-Induced
   Arthralgia in Postmenopausal Breast Cancer Survivors: A Pilot Study
SO ONCOLOGY NURSING FORUM
LA English
DT Article
DE acupressure; aromatase inhibitor-induced arthralgia; breast cancer
   survivors
ID SELF-EFFICACY QUESTIONNAIRE; ADJUVANT HORMONAL-THERAPY;
   CLINICAL-PRACTICE; PAIN; OSTEOARTHRITIS; ACUPUNCTURE; SYMPTOMS;
   OUTCOMES; WOMEN; TRIAL
AB Purpose/Objectives: To assess the feasibility of auricular point acupressure to manage aromatase inhibitor-induced arthralgia.
   Design: Wait list control design.
   Setting: Outpatient clinics and oncology center.
   Sample: 20 women with aromatase inhibitor-induced arthralgia.
   Methods: After baseline data were collected, participants waited one month before they received acupressure once per week for four weeks at a convenient time. The baseline data served as the control comparison. Self-reported measures and blood samples were obtained at baseline, at preintervention, weekly during the intervention, and at post intervention.
   Main Research Variables: The primary outcomes included pain intensity, pain interference, stiffness, and physical function. Inflammatory cytokines and chemokines were tested.
   Findings: After the four-week intervention, participants reported decreases in worst pain and pain interference, and improvements in physical function, cancer-related symptom severity, and interference. The proinflammatory cytokines and chemokines displayed a trend of a mean percentage reduction. The anti-inflammatory cytokine interieukin-13 increased from pre- to postintervention.
   Conclusions: Auricular point acupressure is feasible and may be effective in managing arthralgia in breast cancer survivors.
   Implications for Nursing: Nurses can administer acupressure in clinical settings, which could enhance the management of aromatase inhibitor-induced arthraigia and contribute to a shift from traditional disease-based biomedical models to a broader, integrative, medical paradigm for managing aromatase inhibitor-induced arthraigia.
C1 [Yeh, Chao Hsing] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
   [Lin, Wei-Chun; Park, Na-Jin] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15260 USA.
   [Suen, Lorna Kwai-Ping] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Hong Kong, Peoples R China.
   [Wood, Lisa J.] MGH Inst Hlth Profess, Nursing Res, Charlestown, MA USA.
   [van Londen, G. J.] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA.
   [van Londen, G. J.] Univ Pittsburgh, Inst Canc, Biobehav Oncol Program, Pittsburgh, PA 15260 USA.
   [Bovbjerg, Dana Howard] Hillman Canc Ctr, Pittsburgh, PA USA.
C3 Johns Hopkins University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Hong Kong Polytechnic
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Yeh, CH (corresponding author), Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
EM cyeh13@jhu.edu
RI ; Suen, Lorna/F-5077-2014
OI van Londen, GJ/0000-0001-6047-6172; Wood Magee,
   Lisa/0000-0003-1145-3649; Lin, Wei-Chun/0000-0002-2226-4619
FU American Cancer Society [124638-PEP-13-237-01-PCSM]
FX This research was funded by a grant to Yeh from the American Cancer
   Society (124638-PEP-13-237-01-PCSM). Mention of specific products and
   opinions related to those products do not indicate or imply endorsement
   by the Oncology Nursing Society.
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NR 70
TC 22
Z9 25
U1 2
U2 17
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD JUL
PY 2017
VL 44
IS 4
BP 476
EP 487
DI 10.1188/17.ONF.476-487
PG 12
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA FX9GK
UT WOS:000426406400010
PM 28632237
DA 2026-01-16
ER

PT J
AU Li, DH
   Su, YF
   Fan, HF
   Guo, N
   Sun, CX
AF Li, De-hui
   Su, Yi-fan
   Fan, Huan-fang
   Guo, Na
   Sun, Chun-xia
TI Acupuncture Combined with Three-Step Analgesic Drug Therapy for
   Treatment of Cancer Pain: A Systematic Review and Meta-Analysis of
   Randomised Clinical Trials
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID MECHANISM
AB Objective. The purpose of this study was to systematically evaluate the efficacy and safety of acupuncture combined with the WHO three-step analgesic drug ladder for cancer pain. Methods. The Cochrane Library, PubMed, and CNKI Database of Systematic Reviews were searched. Using the Cochrane Register for Randomized Controlled Trials, the quality of the included literature was evaluated, and the meta-analysis was carried out with RevMan 5.3 software. Results. Compared with three-step analgesia alone, acupuncture combined with three-step analgesia for cancer pain increased pain relief response rates (RR = 1.12, 95% CI: 1.08 similar to 1.17, P<0.00001), reduced NRS score (SMD = -1.10, 95% CI: -1.86 similar to-0.35, P=0.004), reduced the rate of side effects (RR = 0.45, 95% CI: 0.38 similar to 0.53, P<0.00001), including nausea (P<0.00001), vomiting (P=0.008), constipation (P<0.00001), and dizziness (P=0.010), reduced the burst pain rate (SMD = -1.38; 95% CI: -2.44 similar to-0.32, P=0.01), shortened analgesia effect onset time (P=0.004), and extended the duration of response (P<0.0001). Conclusion. For the treatment of cancer pain, acupuncture combined with three-step analgesic drugs is better than using only three-step analgesic drugs.
C1 [Li, De-hui; Su, Yi-fan; Fan, Huan-fang; Guo, Na; Sun, Chun-xia] Hebei Univ Chinese Med, Affiliated Hosp 1, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China.
   [Su, Yi-fan] Hebei Univ Chinese Med, Grad Sch, Shijiazhuang 050091, Hebei, Peoples R China.
C3 Hebei University of Chinese Medicine; Hebei University of Chinese
   Medicine
RP Li, DH (corresponding author), Hebei Univ Chinese Med, Affiliated Hosp 1, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China.
EM 258289951@qq.com; 2088302387@qq.com; fhf701024@163.com;
   guona731@163.com; schx1975@163.com
RI Li, Dehui/IRZ-6284-2023
FU National Natural Science Foundation of China [81603412]; Key R&D
   Projects of Hebei Province [18277731D]; Scientific Research Project of
   Hebei Administration of Traditional Chinese Medicine [2017163, 2019008,
   2020014]; General Projects for Improving Scientific Research Capacity of
   Hebei College of Traditional Chinese Medicine [KTY2019009]; Hebei Key
   Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular
   Disease; Key Laboratory of Integrated Traditional Chinese and Western
   Medicine Hepatonephrosis in Hebei Province [A201902]; Hebei Province
   "Three Three Three Talent Project" [A202002008]
FX This research was supported by the National Natural Science Foundation
   of China (Grant no. 81603412); Key R&D Projects of Hebei Province (Grant
   no. 18277731D); Scientific Research Project of Hebei Administration of
   Traditional Chinese Medicine (Grants nos. 2017163, 2019008, and
   2020014); General Projects for Improving Scientific Research Capacity of
   Hebei College of Traditional Chinese Medicine (Grant no. KTY2019009);
   Hebei Key Laboratory of Chinese Medicine Research on
   Cardio-Cerebrovascular Disease; Key Laboratory of Integrated Traditional
   Chinese and Western Medicine Hepatonephrosis in Hebei Province (Grant
   no. A201902); and Hebei Province "Three Three Three Talent Project"
   funded project (Grant no. A202002008).
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NR 37
TC 22
Z9 24
U1 1
U2 35
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUL 26
PY 2021
VL 2021
AR 5558590
DI 10.1155/2021/5558590
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TZ2YW
UT WOS:000684343100007
PM 34349826
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Molassiotis, A
   Russell, W
   Hughes, J
   Breckons, M
   Lloyd-Williams, M
   Richardson, J
   Hulme, C
   Brearley, SG
   Campbell, M
   Garrow, A
   Ryder, WD
AF Molassiotis, Alexander
   Russell, Wanda
   Hughes, John
   Breckons, Matthew
   Lloyd-Williams, Mari
   Richardson, Janet
   Hulme, Claire
   Brearley, Sarah G.
   Campbell, Malcolm
   Garrow, Adam
   Ryder, W. David
TI The Effectiveness of Acupressure for the Control and Management of
   Chemotherapy-Related Acute and Delayed Nausea: A Randomized Controlled
   Trial
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Acupressure; nausea; vomiting; chemotherapy
ID ACUSTIMULATION WRIST BANDS; POSTCHEMOTHERAPY NAUSEA;
   CANCER-CHEMOTHERAPY; INDUCED EMESIS; ACUPUNCTURE; ONCOLOGY; P6;
   STIMULATION; ANTIEMETICS; PROPHYLAXIS
AB Context. Both positive and negative results have been reported in the literature from the use of acupressure at the P6 point, providing evidence of highly suggestive but not conclusive results.
   Objectives. To clarify whether acupressure is effective in the management of chemotherapy-related nausea and vomiting.
   Methods. A randomized, three-group, sham-controlled trial was designed. Patients with cancer receiving chemotherapy were randomized to receive standardized antiemetics and acupressure wristbands, sham acupressure wristbands, or antiemetics alone. Primary outcome assessment (nausea) was carried out daily for seven days per chemotherapy cycle over four cycles. Secondary outcomes included vomiting, psychological distress, and quality of life.
   Results. Five hundred patients were randomized. Primary outcome analysis (nausea in Cycle 1) revealed no statistically significant differences between the three groups, although nausea levels in the proportion of patients using wristbands (both real and sham) were somewhat lower than those in the proportion of patients using antiemetics-only group. Adjusting for gender, age, and emetic risk of chemotherapy, the odds ratio of lower nausea experience was 1.18 and 1.42 for the acupressure and sham acupressure groups, respectively. A gender interaction effect was evident (P = 0.002). No significant differences were detected in relation to vomiting, anxiety, and quality-of-life measures.
   Conclusion. No clear recommendations can be made about the use of acupressure wristbands in the management of chemotherapy-related nausea and vomiting as results did not reach statistical significance. However, the study provided evidence of encouraging signals in relation to improved nausea experience and warrants further consideration in both practice and further clinical trials. (C) 2014 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
C1 [Molassiotis, Alexander; Russell, Wanda; Campbell, Malcolm] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Hughes, John; Lloyd-Williams, Mari] Univ Liverpool, Div Primary Care, Acad Palliat & Support Care Studies Grp, Liverpool L69 3BX, Merseyside, England.
   [Breckons, Matthew; Richardson, Janet] Univ Plymouth, Fac Hlth, Plymouth PL4 8AA, Devon, England.
   [Hulme, Claire] Univ Leeds, Leeds Inst Hlth Sci, Acad Unit Hlth Econ, Leeds, W Yorkshire, England.
   [Brearley, Sarah G.] Univ Lancaster, Fac Hlth & Med, Lancaster, England.
   [Garrow, Adam] Univ Salford, Sch Hlth Sci, Manchester, Lancs, England.
   [Ryder, W. David] Christie NHS Fdn Trust, Clin Trials Unit, Manchester, Lancs, England.
C3 University of Manchester; University of Liverpool; University of
   Plymouth; University of Leeds; Lancaster University; University of
   Salford; Christie NHS Foundation Trust
RP Molassiotis, A (corresponding author), Univ Manchester, Sch Nursing Midwifery & Social Work, Univ Pl, Manchester M13 9PL, Lancs, England.
EM alex.molassiotis@manchester.ac.uk
RI Campbell, Malcolm/D-3925-2011; Hulme, Charles/B-4115-2013; Molassiotis,
   Alex/MDS-6695-2025; Russell, Wanda/O-9051-2014; Brearley, Sarah
   Grace/A-3257-2011
OI Molassiotis, Alex/0000-0001-6351-9991; Lloyd-Willia,
   Mari/0000-0002-9590-5288; Russell, Wanda/0000-0003-2671-1938; Hulme,
   Claire/0000-0003-2077-0419; Brearley, Sarah Grace/0000-0003-4764-3276;
   Hughes, John/0000-0002-4513-2395
FU National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) program [07/31/02]
FX This project was funded by the National Institute for Health Research
   (NIHR) Health Technology Assessment (HTA) program (project number
   07/31/02) and will be published in full in Health Technology Assessment
   2013, vol. 13. See the HTA program Web site for further project
   information (http://www.hta.ac.uk/research/HTAjournal. shtml). The
   authors declare no conflicts of interest. This report presents
   independent research commissioned by the NIHR. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the National Health Service, NIHR, NIHR Evaluation,
   Trials and Studies Coordinating Centre, HTA program, or Department of
   Health. The authors acknowledge the contribution of the National Cancer
   Research Network research nurses across the 14 trial sites who recruited
   patients to the trial, the steering group members, and the data and
   ethics committee members of the trial.
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NR 46
TC 33
Z9 39
U1 0
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JAN
PY 2014
VL 47
IS 1
BP 12
EP 25
DI 10.1016/j.jpainsymman.2013.03.007
PG 14
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 285YF
UT WOS:000329430300007
PM 23602325
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Elliott, T
   Gomez, MM
   Morris, D
   Wilson, C
   Pilitsis, JG
AF Elliott, Trish
   Gomez, Maria Merlano
   Morris, Deborah
   Wilson, Candy
   Pilitsis, Julie G.
TI A scoping review of mechanisms of auricular acupuncture for treatment of
   pain
SO POSTGRADUATE MEDICINE
LA English
DT Review
DE Auricular acupuncture; battlefield acupuncture (BFA); mechanism;
   naloxone; endorphins; pain management
ID LOW-BACK-PAIN; BATTLEFIELD ACUPUNCTURE; EAR-ACUPUNCTURE;
   ELECTRICAL-STIMULATION; POSTOPERATIVE PAIN; POINT ACUPRESSURE; CANCER
   SURVIVORS; MANAGEMENT; AURICULOTHERAPY; HEALTH
AB ObjectivesAuricular acupuncture (AA) is becoming increasingly common in primary care clinics, emergency departments and peri-operatively for pain relief. Over the last decade, since the last comprehensive reviews were published, the literature has expanded. In this scoping review, we seek to document the efficacy of AA in treating both acute and chronic pain, describe the mechanism of action of AA in treating pain, and discuss how AA has been integrated into Western medicine to date.MethodsThe authors performed a MEDLINE search inclusive of articles from 1966 to June 2023 including articles written in English identifying literature. We included human studies when more than 3 patients were included. Three hundred and fourteen unique articles were identified and 152 were selected by title screen. After abstract review, 117 were chosen for full-text review. Following full-text review, 33 articles were excluded and 21 added from references, totaling 105 articles included in our scoping review.ResultsAA reduces pain severity in patients with both acute and chronic pain. The best studies in the acute settings have occurred in the peri-operative setting where sham AA is employed, multiple sessions of AA are given, and medication dosing is carefully monitored. In these cases, AA reduced pain and post-operative medications. In patients with chronic pain, multiple sessions of AA resulted not only in pain relief but also in improvements in function and disability. Literature suggests that AA works through multiple mechanisms with the most compelling data coupled to the autonomic nervous system and neuroendocrine system. Curriculums designed to teach AA and aid in implementation have been published.ConclusionAA is an accessible, effective means of pain relief. AA is relatively straightforward to learn, and protocols and curriculums exist to teach healthcare professionals this valuable skill. Overcoming implementation barriers, including patient education, are essential next steps.
   This review was written to analyze the current research on an increasingly popular pain relief treatment, auricular acupuncture. Auricular acupuncture has been an effective method of pain relief for patients with short-term pain. People who experienced pain after surgery and received auricular acupuncture experienced a decrease in pain and pain medications. Patients with chronic pain who underwent auricular acupuncture experienced pain relief and an increase in their functional abilities. Auricular acupuncture is thought to affect the body's autonomic nervous system and neuroendocrine system as it creates its source of pain relief for the body. Auricular acupuncture is increasingly popular in the education of healthcare workers and clinical practice. Research shows auricular acupuncture is an effective, easy, and less expensive method of pain relief, whose growth in pain management use may benefit from further education, especially for patients.
C1 [Elliott, Trish; Gomez, Maria Merlano] Florida Atlantic Univ, Charles E Schmidt Coll Med, Boca Raton, FL USA.
   [Morris, Deborah; Pilitsis, Julie G.] Univ Arizona, Dept Neurosurg, Coll Med, Tucson, AZ 85724 USA.
   [Wilson, Candy] Florida Atlantic Univ, Christine E Lynn Coll Nursing, Boca Raton, FL USA.
   [Pilitsis, Julie G.] Univ Arizona, Coll Med, Arizona Hlth Sci Ctr, Dept Neurosurg, Bldg 201 Suite 4303 POB 245070, Tucson, AZ 85724 USA.
C3 State University System of Florida; Florida Atlantic University;
   University of Arizona; State University System of Florida; Florida
   Atlantic University; University of Arizona; University of Arizona Health
   Sciences
RP Pilitsis, JG (corresponding author), Univ Arizona, Coll Med, Arizona Hlth Sci Ctr, Dept Neurosurg, Bldg 201 Suite 4303 POB 245070, Tucson, AZ 85724 USA.
EM jpilitsis@arizona.edu
RI Wilson, Candy/HLH-2484-2023
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NR 105
TC 11
Z9 11
U1 7
U2 32
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD APR 2
PY 2024
VL 136
IS 3
BP 255
EP 265
DI 10.1080/00325481.2024.2333232
EA APR 2024
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SF0M6
UT WOS:001195700200001
PM 38501597
DA 2026-01-16
ER

PT J
AU Qi, QL
   Han, X
   Tang, C
AF Qi, Qing-ling
   Han, Xue
   Tang, Cheng
TI Effects of Acupuncture on Breast Cancer Patients Taking Aromatase
   Inhibitors
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID INDUCED ARTHRALGIA; CONTROLLED-TRIAL; JOINT SYMPTOMS; DOUBLE-BLIND;
   DUAL-CENTER; WOMEN; ELECTROACUPUNCTURE; MANAGEMENT; FATIGUE
AB Although acupuncture has been used in clinical practice for thousands of years, it remains a controversial treatment option to help alleviate pain in cancer patients. In this study, we analyzed published material on randomized trials of acupuncture from MEDLINE published up until July 31, 2018, to assess its effects on pain experienced by cancer patients. Revman 5.0 software was used to conduct meta-analysis with pain score as the index. The results of nine randomized controlled trials involving 592 patients were analyzed and showed that acupuncture can relieve the pain caused by aromatase inhibitors. Weighted mean difference of worst pain and pain severity was-3.03, 95% CI (-3.90,-2.16) and-2.69, 95% CI (-4.08,-1.30), respectively (P < 0:01). This led us to conclude that acupuncture has pain relieving effects against pain caused by aromatase inhibitors.
C1 [Qi, Qing-ling; Han, Xue] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin 300381, Peoples R China.
   [Tang, Cheng] Tianjin Med Univ, Sch Pharm, Tianjin 300070, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin Medical
   University
RP Qi, QL (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin 300381, Peoples R China.
EM qiqinglingdr@163.com; hhhhhxue163@163.com; tangcheng@tmu.edu.cn
FU Natural Science Foundation of First Teaching Hospital of Tianjin
   University of Traditional Chinese Medicine;  [201920]
FX AcknowledgmentsThis work was supported by the Natural Science Foundation
   of First Teaching Hospital of Tianjin University of Traditional Chinese
   Medicine (no. 201920).
CR Bae K, 2015, INTEGR CANCER THER, V14, P496, DOI 10.1177/1534735415596573
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NR 20
TC 4
Z9 5
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD SEP 12
PY 2022
VL 2022
AR 1164355
DI 10.1155/2022/1164355
PG 4
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 5C8BX
UT WOS:000864480200007
PM 36132087
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Witt, CM
AF Mao, Jun J. J.
   Witt, Claudia M. M.
TI Acupuncture as an Evidence-Based Treatment for Cancer Pain Management:
   The Joint Society for Integrative Oncology-American Society for Clinical
   Oncology Guideline
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID ALTERNATIVE MEDICINE USE; AROMATASE INHIBITORS; BREAST-CANCER;
   UNITED-STATES; COMPLEMENTARY; SURVIVORS
C1 [Mao, Jun J. J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, New York, NY USA.
   [Witt, Claudia M. M.] Univ Hosp Zurich, Inst Complementary & Integrat Med, Zurich, Switzerland.
   [Witt, Claudia M. M.] Univ Zurich, Zurich, Switzerland.
   [Mao, Jun J. J.] Mem Sloan Kettering Canc Ctr, 321 East 61st St,Room 456, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; University of Zurich; University
   Zurich Hospital; University of Zurich; Memorial Sloan Kettering Cancer
   Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, 321 East 61st St,Room 456, New York, NY 10065 USA.
EM maoj@mskcc.org
RI Witt med, Claudia M/AAX-2370-2021
OI Witt med, Claudia M/0000-0002-5440-7805
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NR 20
TC 5
Z9 5
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD APR 1
PY 2023
VL 29
IS 4
BP 209
EP 211
DI 10.1089/jicm.2023.0018
EA FEB 2023
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA D7WA4
UT WOS:000939704300001
PM 36847338
DA 2026-01-16
ER

PT J
AU Yu, QT
   Wang, XR
   Wu, JQ
   Zhang, QY
   Ying, XQ
   Ou, LM
   Hu, HT
   He, KL
   Wu, L
   Jin, ZD
   Shentu, J
   Dai, HF
   Ma, RJ
   Hu, QM
   Han, DX
AF Yu, Qintao
   Wang, Xinru
   Wu, Jiaqi
   Zhang, Qiyuan
   Ying, Xiaoqi
   Ou, Liming
   Hu, Hantong
   He, Kelin
   Wu, Lei
   Jin, Zongda
   Shentu, Jiajun
   Dai, Huifeng
   Ma, Ruijie
   Hu, Qimiao
   Han, Dexiong
TI Efficacy and Safety of Electroacupuncture for Postherpetic Neuralgia and
   Biomarker Evaluation: A Study Protocol for a Multicenter, Randomized
   Trial
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE electroacupuncture; postherpetic neuralgia; biomarker; sham acupuncture;
   randomized controlled trial; study protocol
ID HERPES-ZOSTER
AB Introduction: Postherpetic neuralgia (PHN) is a persistent neuropathic pain condition that endures for at least 3 months following the onset of herpes zoster, significantly impairing life quality of patients. Current PHN treatments demonstrate limited efficacy, and the lack of reliable severity biomarkers hinders effective clinical management. Electroacupuncture represents a promising therapeutic approach for PHN, though comprehensive evidence supporting its efficacy and safety is still needed. Furthermore, as objective indicators, the role of serum biomarkers in assessments still requires further investigation. Methods: This multicenter, sham-controlled, randomized study will recruit 180 patients with PHN. Participants will be allocated in a 1:1:1 ratio to electroacupuncture, sham acupuncture, or waiting-list groups via multicenter stratified block randomization. Participants will receive 1-month of treatment and 3-month follow-ups. The electroacupuncture group and the sham acupuncture group will each receive 12 treatments. All participants will maintain their pre-enrollment medication. Primary outcome is Numerical Rating Scale; secondary outcomes include pain episode frequency, Hamilton Anxiety Scale, Hamilton Depression Scale, The Short-Form 36 Health Survey, and changes of biomarkers (Neuropeptide Y, Substance P, Tumor Necrosis Factor-alpha, Interleukin-10). A linear mixed-effects model will be used to analyze data at different time points to explore the efficacy of electroacupuncture and the correlation between serum biomarkers and pain intensity. The predictive value of biomarkers for refractory postherpetic neuralgia (NRS reduction <30% from baseline post-treatment) will be assessed using ROC curves. Conclusion: The expected outcomes will clarify the efficacy and safety of electroacupuncture for PHN. The study will also analyze the correlation between serum biomarkers and pain symptoms and determine whether serum biomarkers can serve as prognostic indicators for refractory postherpetic neuralgia.
C1 [Yu, Qintao; Wang, Xinru; Wu, Jiaqi; Zhang, Qiyuan; Ying, Xiaoqi; Ou, Liming] Zhejiang Chinese Med Univ, Sch Clin Med 3, Sch Rehabil Med, Hangzhou, Peoples R China.
   [Hu, Hantong; He, Kelin; Wu, Lei; Ma, Ruijie; Hu, Qimiao; Han, Dexiong] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Acupuncture & Moxibust, 219 Moganshan Rd, Hangzhou, Peoples R China.
   [Jin, Zongda] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Med Affairs, Hangzhou, Peoples R China.
   [Shentu, Jiajun] Hangzhou Third Peoples Hosp, Dept Acupuncture & Moxibust, Hangzhou, Zhejiang, Peoples R China.
   [Dai, Huifeng] Changxing Cty Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, Huzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University
RP Hu, QM; Han, DX (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Acupuncture & Moxibust, 219 Moganshan Rd, Hangzhou, Peoples R China.
EM huqimiao315@126.com; han_0213@163.com
RI ; Hu, Hantong/GYJ-2069-2022; Wang, Xinru/AAR-1510-2021; Hu,
   qimiao/NYT-1144-2025
OI Wu, Lei/0000-0001-7055-7865; Hu, Hantong/0000-0001-8759-5083; 
FU Science and Technology Co-construction Project of the National
   Comprehensive Reform Demonstration Zone for Traditional Chinese Medicine
   [GZY-KJS-ZJ-2025-024]; Zhejiang Province Health High-level Talent
   Project [[2021] 40 (cxrc202102)]; Zhejiang Province High-Level Health
   Talent Project (Zhejiang Health Office [2021]) [40]
FX The trial is financially funded by the Science and Technology
   Co-construction Project of the National Comprehensive Reform
   Demonstration Zone for Traditional Chinese Medicine
   (GZY-KJS-ZJ-2025-024) and the Zhejiang Province Health High-level Talent
   Project [2021] 40 (cxrc202102), the Zhejiang Province High-Level Health
   Talent Project (Zhejiang Health Office [2021] No. 40) .
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NR 55
TC 1
Z9 1
U1 3
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2025
VL 18
BP 5753
EP 5768
DI 10.2147/JPR.S559309
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9KQ8T
UT WOS:001608634800001
PM 41199896
OA gold
DA 2026-01-16
ER

PT J
AU Saramago, P
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   Weatherly, H.
   Manca, A.
   Sculpher, M. J.
   MacPherson, H.
TI COMPARATIVE EFFECTIVENESS OF ACTIVE VERSUS SHAM ACUPUNCTURE VERSUS USUAL
   CARE IN THE MANAGEMENT OF CHRONIC, NON-CANCER PAIN IN PRIMARY CARE
SO VALUE IN HEALTH
LA English
DT Meeting Abstract
C1 [Saramago, P.; Weatherly, H.; Sculpher, M. J.; MacPherson, H.] Univ York, York YO10 5DD, N Yorkshire, England.
   [Manca, A.] Univ York, Heslington, England.
C3 University of York - UK; University of York - UK
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1098-3015
EI 1524-4733
J9 VALUE HEALTH
JI Value Health
PD NOV
PY 2013
VL 16
IS 7
BP A556
EP A557
DI 10.1016/j.jval.2013.08.1456
PG 2
WC Economics; Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Health Care Sciences & Services
GA 242MY
UT WOS:000326247602060
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Farrar, JT
   Bruner, D
   Zee, J
   Bowman, M
   Seluzicki, C
   DeMichele, A
   Xie, SX
AF Mao, Jun J.
   Farrar, John T.
   Bruner, Deborah
   Zee, Jarcy
   Bowman, Marjorie
   Seluzicki, Christina
   DeMichele, Angela
   Xie, Sharon X.
TI Electroacupuncture for Fatigue, Sleep, and Psychological Distress in
   Breast Cancer Patients With Aromatase Inhibitor-Related Arthralgia: A
   Randomized Trial
SO CANCER
LA English
DT Article
DE acupuncture; breast neoplasm; aromatase inhibitors; fatigue; sleep;
   psychological distress
ID SYMPTOM CLUSTER; HOSPITAL ANXIETY; ACUPUNCTURE; DEPRESSION; PAIN;
   DISCONTINUATION; MANAGEMENT; SEVERITY; PATTERNS; SYSTEM
AB BACKGROUNDAlthough fatigue, sleep disturbance, depression, and anxiety are associated with pain in breast cancer patients, it is unknown whether acupuncture can decrease these comorbid symptoms in cancer patients with pain. The objective of this study was to evaluate the effect of electroacupuncture (EA) on fatigue, sleep, and psychological distress in breast cancer survivors who experience joint pain related to aromatase inhibitors (AIs).
   METHODSThe authors performed a randomized controlled trial of an 8-week course of EA compared with a waitlist control (WLC) group and a sham acupuncture (SA) group in postmenopausal women with breast cancer who self-reported joint pain attributable to AIs. Fatigue, sleep disturbance, anxiety, and depression were measured using the Brief Fatigue Inventory (BFI), the Pittsburgh Sleep Quality Index (PSQI), and the Hospital Anxiety and Depression Scale (HADS). The effects of EA and SA versus WLC on these outcomes were evaluated using mixed-effects models.
   RESULTSOf the 67 randomly assigned patients, baseline pain interference was associated with fatigue (Pearson correlation coefficient [r]=0.75; P < .001), sleep disturbance (r=0.38; P=.0026), and depression (r=0.58; P < .001). Compared with the WLC condition, EA produced significant improvements in fatigue (P=.0095), anxiety (P=.044), and depression (P=.015) and a nonsignificant improvement in sleep disturbance (P=.058) during the 12-week intervention and follow-up period. In contrast, SA did not produce significant reductions in fatigue or anxiety symptoms but did produce a significant improvement in depression compared with the WLC condition (P=.0088).
   CONCLUSIONSCompared with usual care, EA produced significant improvements in fatigue, anxiety, and depression; whereas SA improved only depression in women experiencing AI-related arthralgia. Cancer 2014;120:3744-3751. (c) 2014 American Cancer Society.
   In this randomized controlled trial among breast cancer patients who experience arthralgia related to aromatase, electroacupuncture produces significant improvements in fatigue, anxiety, and depression, whereas sham acupuncture improves only depression compared with usual care.
C1 [Mao, Jun J.; Farrar, John T.; DeMichele, Angela] Hosp Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Farrar, John T.; Zee, Jarcy; Seluzicki, Christina; DeMichele, Angela; Xie, Sharon X.] Univ Penn, Ctr Clin Epidemiol & Biostat, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
   [Mao, Jun J.; Seluzicki, Christina] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Bruner, Deborah] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
   [Bowman, Marjorie] Wright State Univ, Sch Med, Dayton, OH USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; Emory University; University System of Ohio; Wright State
   University Dayton
RP Mao, JJ (corresponding author), Univ Penn, Dept Family Med & Community Hlth, 227 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA.
EM jun.mao@uphs.upenn.edu
RI ; Mao, Jun/F-5009-2012; Farrar, John/AAP-4788-2021; Xie,
   Sharon/JCO-7144-2023; bowman, marjorie/F-7235-2013
OI Bruner, Deborah/0000-0002-5770-9948; Zee, Jarcy/0000-0003-0586-1160;
   bowman, marjorie/0000-0002-1945-9212
FU National Institutes of Health (National Center for Complementary and
   Alternative Medicine [NCCAM]) [R21 AT004695]; NCCAM [K23 AT004112]
FX This study was supported by the National Institutes of Health (National
   Center for Complementary and Alternative Medicine [NCCAM] R21 AT004695).
   Dr. Mao is a recipient of the NCCAM K23 AT004112 award.
CR Bao T, 2013, BREAST CANCER RES TR, V138, P167, DOI 10.1007/s10549-013-2427-z
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NR 28
TC 124
Z9 142
U1 2
U2 67
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD DEC 1
PY 2014
VL 120
IS 23
BP 3744
EP 3751
DI 10.1002/cncr.28917
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AU0QU
UT WOS:000345329600024
PM 25077452
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Li, XT
   Lampson, K
   Rosa, WE
   Li, QS
   Ramalingam, MB
   Epstein, AS
   Mao, JJ
AF Li, Xiaotong
   Lampson, Kaitlin
   Rosa, William E.
   Li, Q. Susan
   Ramalingam, Mothi Babu
   Epstein, Andrew S.
   Mao, Jun J.
TI Effect of acupuncture on fatigue in cancer survivors with chronic pain:
   a secondary analysis
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Acupuncture; Fatigue; Cancer survivors; Chronic pain; Clinical trial
ID QUALITY-OF-LIFE; BREAST-CANCER; PSYCHOLOGICAL DISTRESS; MECHANISMS;
   SLEEP
AB PurposeFatigue is one of the most common and troublesome symptoms in cancer survivors and is strongly correlated with pain. We evaluated the effect of acupuncture versus usual care for fatigue among cancer survivors with chronic pain.MethodsWe analyzed data from a randomized clinical trial comparing the effect of electro-acupuncture (EA) or battlefield acupuncture (BFA) versus waitlist control (WLC) for chronic musculoskeletal pain in cancer survivors. Analysis included participants who reported moderate or severe fatigue at baseline. Interventions were delivered over 10 weeks. Fatigue severity was measured using the Brief Fatigue Inventory (BFI).ResultsAmong 274 participants (mean age 61.0 years [standard deviation (SD)] 12.8; 73.0% women), the baseline BFI worst fatigue score was 7.1 (SD 1.7). EA and BFA were associated with reductions in worst fatigue score of 2.4 points (95% confidence interval [CI]: - 2.9 to - 1.9) and 2.0 points (95% CI: - 2.5 to - 1.5) from baseline to week 12. There was no significant between-group difference. A higher proportion of patients in both EA and BFA experienced clinically meaningful fatigue improvement compared to WLC (61.2% and 51.6% vs. 37.3%, p = 0.019). Fatigue reductions persisted at week 24 (EA: -2.1 points [95% CI: -2.6 to -1.7]; BFA: -2.2 points [95% CI: -2.8 to -1.7]).ConclusionCancer survivors with chronic pain experienced clinically meaningful and durable fatigue reductions when receiving either EA or BFA.Implications for cancer survivorsThese findings support the clinical utility of acupuncture as an evidence-based option for managing fatigue in cancer survivors with pain.Trial registrationClinicalTrials.gov Identifier: NCT02979574; November 30, 2016.
C1 [Li, Xiaotong; Lampson, Kaitlin; Li, Q. Susan; Epstein, Andrew S.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
   [Rosa, William E.] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY USA.
   [Ramalingam, Mothi Babu] Singapore Gen Hosp, Dept Rehabil Med, Singapore, Singapore.
   [Epstein, Andrew S.] Cornell Univ, Weill Cornell Med Coll, New York, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Singapore General Hospital; Cornell University; Weill Cornell
   Medicine
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
EM maoj@mskcc.org
OI Rosa, William/0000-0002-0680-8911
FU National Cancer Institute [P30 CA008748]
FX This work was supported by the Department of Defense office of the
   Congressionally Directed Medical Research Programs through the Peer
   Reviewed Medical Research Program Clinical Trial Award
   (W81XWH-15-1-0245). This work was also funded in part through the
   NIH/NCI Cancer Center Support Grant P30 CA008748.
CR Balk Judith, 2009, J Soc Integr Oncol, V7, P4
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD DEC 13
PY 2025
VL 34
IS 1
AR 31
DI 10.1007/s00520-025-10219-z
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA U6739
UT WOS:001638835500003
PM 41389238
DA 2026-01-16
ER

PT J
AU Wang, YH
   Zhou, MF
   Shen, JM
   Wang, DS
   Xu, N
   Song, YF
   Sun, MZ
   Chen, L
   Pei, LX
   Sun, JH
AF Wang, Yuhang
   Zhou, Mingfei
   Shen, Jianmei
   Wang, Dongsheng
   Xu, Na
   Song, Yafang
   Sun, Mengzhu
   Chen, Lu
   Pei, Lixia
   Sun, Jianhua
TI Effect of electroacupuncture on chemotherapy-induced diarrhea: study
   protocol for a randomized controlled trial
SO TRANSLATIONAL CANCER RESEARCH
LA English
DT Article
DE Chemotherapy-induced diarrhea (CID); cancer; acupuncture; randomized
   controlled trial
ID ACUPUNCTURE; MANAGEMENT; PAIN; PREVENTION; THERAPIES; CARE
AB Background: Chemotherapy-induced diarrhea (CID) is one of the side effects of chemotherapy. Diarrhea not only affects the overall treatment effectiveness but also reduces patients' quality of life. Severe diarrhea can lead to electrolyte imbalance and even be life-threatening. Although acupuncture has been widely used in clinical practice and its effectiveness for managing functional diarrhea has been recognized, there is no sound evidence of its efficacy in managing CID. Therefore, the aim of the proposed randomized controlled trial is to examine the effectiveness and potential risks of using acupuncture for the management of CID and to describe its protocol herein.
   Methods: This trial will be conducted in a double-blinded manner and comprise two arms that will be investigated across multiple centers in parallel. The study cohort will comprise 168 outpatients who have CID from six Chinese hospitals. The patients will be randomly and equally divided between an intervention group (electroacupuncture) and a control group (micro-electroacupuncture). In the former, acupuncture will be performed with the conventional method to induce the de qi sensation, and in the latter group, acupuncture will be performed with a sham procedure that does not involve the insertion of needles. The acupoints ST25, SP14, SP6, and ST37 will be applied in the two methods. These procedures will be performed three times a week for four consecutive weeks. The number of days on which CID occurred, the incidence of CID, and fecal characteristics are considered as the primary outcomes, and the Functional Assessment of Chronic Illness Therapy for Patients with Diarrhea subscale score and the World Health Organization Quality of Life assessment are considered as secondary outcomes. The patients will be closely observed for complications and fluctuations in vital signs.
   Discussion: If the findings from the trial demonstrate the effectiveness and safety of using acupuncture to treat CID, they could serve as evidence for the clinical application of acupuncture as a complementary treatment for cancer patients during chemotherapy.
C1 [Wang, Yuhang; Sun, Mengzhu] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Acupuncture & Rehabil, Nanjing, Peoples R China.
   [Wang, Yuhang; Xu, Na; Song, Yafang; Sun, Mengzhu] Nanjing Univ Chinese Med, Acupuncture & Tuina Acad, Nanjing, Peoples R China.
   [Zhou, Mingfei] Nanjing Xiaohang Hosp, Dept Oncol, Nanjing, Peoples R China.
   [Shen, Jianmei; Wang, Dongsheng] Nanjing Red Cross Hosp, Dept Oncol, Nanjing, Peoples R China.
   [Chen, Lu; Pei, Lixia; Sun, Jianhua] Nanjing Univ Tradit Chinese Med, Affiliated Hosp, Dept Acupuncture & Rehabil, Prov Hosp Tradit Chinese Med, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Sun, JH (corresponding author), Nanjing Univ Tradit Chinese Med, Affiliated Hosp, Dept Acupuncture & Rehabil, Prov Hosp Tradit Chinese Med, Nanjing, Peoples R China.
EM 377201634@qq.com
FU Leading Talents Project of Jiangsu Provincial Administration of TCM
   [SLJ0206]; Nanjing University of Chinese Medicine's Jiangsu University
   Nursing Discipline Construction Funding Project [2019YSHL062]
FX This work was supported by grants from the Leading Talents Project of
   Jiangsu Provincial Administration of TCM (grant no. SLJ0206) and the
   Nanjing University of Chinese Medicine's Jiangsu University Nursing
   Discipline Construction Funding Project (grant no. 2019YSHL062).
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U2 16
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
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SN 2218-676X
EI 2219-6803
J9 TRANSL CANCER RES
JI Transl. Cancer Res.
PD MAY
PY 2021
VL 10
IS 5
BP 2516
EP 2524
DI 10.21037/tcr-20-3400
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SL1RG
UT WOS:000656696500050
PM 35116567
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mahasti, S
   Caroline, B
   Bernard, A
   LI, Y
   NIE, JY
   LIU, DQ
   CHEN, DD
   CHEN, CX
   Estevez, L
   LI, WH
   Armand, JP
   ZHU, MS
   JU, LY
AF Mahasti, Saghachian
   Caroline, Barry
   Bernard, Asselain
   LI Yunfen
   NIE Jianyun
   LIU Dequan
   CHEN Dedian
   CHEN Chunxin
   Estevez, Laura
   LI Wenhui
   Armand, Jean-Pierre
   ZHU Miansheng
   JU Liya
TI An international multicentric phase III randomized controlled trial of
   time-acupoints-space acupuncture for the prevention of
   chemotherapy-induced fatigue in patients with early stage breast cancer:
   a study protocol
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE breast neoplasms; chemotherapy; adjuvant; fatigue; immunity; clinical
   protocols; time-acupoints-space acupuncture
ID MULTIDIMENSIONAL FATIGUE; VALIDATION; STATISTICS; INVENTORY; WOMEN;
   CHINA
AB OBJECTIVE: To determine the difference in prevention of chemotherapy-induced fatigue between time-acupoints-space acupuncture (ATAS) administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide (EC) followed by paclitaxel, as measured by the multi-dimensional fatigue inventory (MFI) over the previous week and Visual Analogue Scale measuring fatigue (VAS-F), and to evaluate the effects of ATAS on self-reported neuropathy pain, sleep, anxiety and depression. METHODS: In this multicenter clinical trial, we have randomized patients into 3 groups: ATAS, Sham and non-acupuncture with an unequal randomization of 2:1:1. A cloud related electronical clinical report form and smartphone platform was established for data entry. Patients with a history of stage I -III breast cancer scheduled to receive adjuvant chemotherapy. Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation. In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture, an evaluation of immune profiling was incorporate in this study. RESULTS: The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment. Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly. Unfortunately, we do not have effective pharmacological interventions yet. And clinical trials of acupuncture in preventing chemotherapy-induced fatigue in patients with early breast cancer have not been reported. CONCLUSION: The findings of the trial will allow us to determine the effects of acupuncture treatment approach. We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments. (c) 2022 JTCM. All rights reserved.
C1 [Mahasti, Saghachian; Armand, Jean-Pierre] Inst Gustave Roussy, Paris, France.
   [Caroline, Barry] Res Ctr Epidemiol & Publ Hlth, Paris, France.
   [Bernard, Asselain] Inst Curie Paris, Paris, France.
   [LI Yunfen; NIE Jianyun; LIU Dequan; CHEN Dedian; LI Wenhui] Kunming Med Univ, Affiliated Hosp 3, Yunnan Canc Hosp, Kunming, Yunnan, Peoples R China.
   [JU Liya] Preci Med Platform Europe, Paris, France.
   [CHEN Chunxin; Estevez, Laura] MD Anderson Canc Hosp, Madrid, Spain.
   [ZHU Miansheng] ARIATAS, Assoc Rech & Informat Acupuncture Time Acupoin Sp, Paris, France.
   [ZHU Miansheng] Yunnan Zhus Expert workstat, Natl Famous Tradit Chinese Med Expert Mian Sheng, Kunming, Yunnan, Peoples R China.
C3 UNICANCER; Gustave Roussy; UNICANCER; Universite PSL; Institut Curie;
   Kunming Medical University
RP JU, LY (corresponding author), Preci Med Platform Europe, Paris, France.; LI, WH (corresponding author), Yunnan Prov Canc Hosp, Kunming, Yunnan, Peoples R China.
EM wenhuili2014@163.com; juliya_eiffel@126.com
RI ; LI, Wenhui/JCD-9947-2023
OI barry, caroline/0000-0001-6668-524X; 
FU France Ruban Rose; Yunnan Provincial Science and Technology Department
   Funding [2018IA059]; PreciMed Platform Europe
FX Supported by PreciMed Platform Europe; a Financial Support from France
   Ruban Rose; the Pilot Clinical Study at Kunming Site was Granted By
   Yunnan Provincial Science and Technology Department Funding (No.
   2018IA059)
CR Bower JE, 2000, J CLIN ONCOL, V18, P743, DOI 10.1200/JCO.2000.18.4.743
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NR 19
TC 2
Z9 3
U1 2
U2 14
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD APR
PY 2022
VL 42
IS 2
BP 289
EP 295
DI 10.19852/j.cnki.jtcm.2022.02.008
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 1B3ZH
UT WOS:000792376500001
PM 35473351
DA 2026-01-16
ER

PT J
AU Li, QY
   Yang, WX
   Yao, LQ
   Chen, H
   Li, ZR
   Gong, YB
   Shi, J
AF Li, Quan-yao
   Yang, Wen-xiao
   Yao, Li-qiu
   Chen, Hong
   Li, Zhen-rui
   Gong, Ya-bin
   Shi, Jun
TI Exploring the Rules of Related Parameters in Transcutaneous Electrical
   Nerve Stimulation for Cancer Pain Based on Data Mining
SO PAIN AND THERAPY
LA English
DT Article
DE Transcutaneous electrical nerve stimulation; Cancer; Cancer pain; Data
   mining; Parameters
ID TENS; FREQUENCY; INTENSITY; TRIAL; SITE
AB IntroductionThis study aims to investigate the regularity of related parameters in the treatment of cancer pain using transcutaneous electrical nerve stimulation (TENS).MethodsA comprehensive literature search was conducted in databases such as PubMed, Cochrane Library, Embase, Web of Science, OVID, CNKI, CBM, VIP, and WANNGFANG from inception up to December 2022. A database was established, and data mining techniques were applied to analyze the relevant TENS parameters.ResultsA total of 27 articles were included, encompassing nine current frequencies, four retention times, four treatment frequencies, and two wave types. On the basis of the analysis of parameter association rules, the most closely related parameter combination for clinical TENS in the treatment of cancer pain was a current frequency of 2/100 Hz, a treatment frequency of once a day, a retention time of 30 min, and the dilatational wave. Moreover, the study involved 22 acupuncture points distributed along 13 meridians. According to the analysis of acupuncture point association rules, Hegu (LI04), Zusanli (ST36), and Sanyinjiao (SP06) were the most closely related acupuncture points and could be used in combination for clinical TENS in cancer pain treatment. Furthermore, cluster analysis was conducted on acupuncture points with a frequency & GE; 5, resulting in three categories: the first category included Sanyinjiao (SP06), Zusanli (ST36), Hegu (LI04), Jiaji point, and Neiguan (PC06); the second category included Ashi point; and the third category included Back shu point.ConclusionIn the treatment of cancer pain using TENS, it is recommended to use a current frequency of 2/100 Hz, a treatment frequency of once a day, a retention time of 30 min, and the dilatational wave. The electrode positions were primarily selected from Ashi point, Back shu point, Sanyinjiao (SP06), Zusanli (ST36), Hegu (LI04), Jiaji point, and Neiguan (PC06) to achieve the best analgesic effect.
C1 [Li, Quan-yao; Yang, Wen-xiao; Chen, Hong; Li, Zhen-rui; Gong, Ya-bin; Shi, Jun] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Shanghai 200437, Peoples R China.
   [Yao, Li-qiu] Jingan Dist Hosp Tradit Chinese Med, Shanghai 200072, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Gong, YB; Shi, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Shanghai 200437, Peoples R China.
EM gongyabin@hotmail.com; shijundoctor@163.com
RI ; Gong, Yabin/MTG-1222-2025; Li, Quanyao/PFZ-4523-2026
OI Shi, Jun/0000-0002-2551-4337; Li, Quanyao/0000-0002-1496-9221
FU National Natural Science Foundation of China [82205213]
FX AcknowledgementsWe thank the participants of the study.FundingThis work
   was supported by National Natural Science Foundation of China (No.
   82205213). The journal's Rapid Service Fee was funded by the
   authors.Author ContributionsWen-xiao Yang obtained funding for the
   study. All authors (Quan-yao Li, Wen-xiao Yang, Li-qiu Yao, Hong Chen,
   Zhen-rui Li, Ya-bin Gong and Jun Shi) conceptualized and designed the
   study. Quan-yao Li, Wen-xiao Yang, Li-qiu Yao, Hong Chen, and Zhen-rui
   Li did the literature retrieval work together. Quan-yao Li and Wen-xiao
   Yang were responsible for literature screening and extracted, assembled,
   analyzed, and interpreted all the data, and drafted the manuscript.
   Ya-bin Gong and Jun Shi conducted a critical review of the manuscript.
   All authors (Quan-yao Li, Wen-xiao Yang, Li-qiu Yao, Hong Chen, Zhen-rui
   Li, Ya-bin Gong and Jun Shi) approved the final version of the
   manuscript.Conflict of InterestAll authors (Quan-yao Li, Wen-xiao Yang,
   Li-qiu Yao, Hong Chen, Zhen-rui Li, Ya-bin Gong and Jun Shi) confirm
   that they have no conflicts of interest to disclose.Compliance with
   Ethics GuidelinesThis article is based on previously conducted studies
   and does not contain any new studies with human participants or animals
   performed by any of the authors.Data AvailabilityThe datasets generated
   during and/or analyzed during the current study are available from the
   corresponding author on reasonable request.
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NR 74
TC 6
Z9 6
U1 2
U2 11
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-8237
EI 2193-651X
J9 PAIN THER
JI PAIN THER.
PD DEC
PY 2023
VL 12
IS 6
BP 1355
EP 1374
DI 10.1007/s40122-023-00549-3
EA AUG 2023
PG 20
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA W4QA8
UT WOS:001048066600001
PM 37578681
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gouveia, DN
   Guimaraes, AG
   Santos, WBD
   Quintans, LJ
AF Gouveia, Daniele Nascimento
   Guimaraes, Adriana Gibara
   da Rocha Santos, Wagner Barbosa
   Quintans-Junior, Lucindo Jose
TI Natural products as a perspective for cancer pain management: A
   systematic review
SO PHYTOMEDICINE
LA English
DT Review
DE Natural products; Cancer pain; Pain
ID TETRACYCLIC TRITERPENE EUPHOL; TANSHINONE-IIA; NEUROPATHIC PAIN;
   ALPHA-TERPINEOL; ESSENTIAL OIL; P-CYMENE; OXIDATIVE STRESS; IN-VITRO;
   BETA-CYCLODEXTRIN; ANTITUMOR-ACTIVITY
AB Background: Cancer is the leading cause of death in the world and one of the main symptoms affecting these individuals is chronic pain, which must be evaluated and treated in its various components. Several drugs are currently used, but beyond the high cost, they have harmful side effects to patients or are transitorily effective. Ergo, there is a need to look for new options for cancer pain relief. Natural products (NPs) present themselves as strong candidates for the development of new drugs for the treatment of chronic pain, such as cancer pain.
   Purpose: This systematic review aimed to summarize current knowledge about the analgesic profile of NPs in cancer pain.
   Methods: The search included PubMed, Scopus and Web of Science (from inception to June 2018) sought to summarize the articles studying new proposals with NPs for the management of oncological pain. Two independent reviewers extracted data on study characteristics, methods and outcomes.
   Results: After an extensive survey, 21 articles were selected, which described the analgesic potential of 15 natural compounds to relieve cancer pain. After analyzing the data, it can be suggested that these NPs, which have targets in central and peripheral mechanisms, are interesting candidates for the treatment of cancer pain for addressing different pharmacological mechanisms (even innovative), but ensuring the safety of these compounds is still a challenge. Likewise, the cannabinoids compounds leave the front as the most promising compounds for direct applicability due to the clinical studies that have already been developed and the background already established about these effects on chronic pain.
   Conclusion: Regarding these findings, it can be concluded that the variability of possible biological sites of action is strategic for new perspectives in the development of therapeutic proposals different from those available in the current market.
C1 [Gouveia, Daniele Nascimento; da Rocha Santos, Wagner Barbosa; Quintans-Junior, Lucindo Jose] Univ Fed Sergipe, Lab Neurociencias & Ensaios Farmacol LANEF, Dept Fisiol, Sao Cristovao, Sergipe, Brazil.
   [Guimaraes, Adriana Gibara] Univ Fed Sergipe, Dept Educ Saude, Av Governador Marcelo Deda 13, Lagarto, Sergipe, Brazil.
C3 Universidade Federal de Sergipe; Universidade Federal de Sergipe
RP Guimaraes, AG (corresponding author), Univ Fed Sergipe, Dept Educ Saude, Av Governador Marcelo Deda 13, Lagarto, Sergipe, Brazil.
EM adrianagibara@pq.cnpq.br
RI ; Guimarães, Aiana/G-6860-2014; Quintans, Lucindo/A-2434-2012
OI Barbosa da Rocha Santos, Wagner/0000-0002-1922-4608; Guimarães,
   Aiana/0000-0003-1643-5642; Quintans, Lucindo/0000-0001-5155-938X
FU Foundation for Research and Technological Innovation Support of the
   State of Sergipe (Fundacao de Apoio a Pesquisa e Inovacao Tecnologica do
   Estado de Sergipe - FAPITEC/SE); National Council of Technological and
   Scientific Development (Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico - CNPq/Brazil); Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior (CAPES/Brazil)
FX We thank grants from the Foundation for Research and Technological
   Innovation Support of the State of Sergipe (Fundacao de Apoio a Pesquisa
   e Inovacao Tecnologica do Estado de Sergipe - FAPITEC/SE) and the
   National Council of Technological and Scientific Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq/Brazil) and
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES/Brazil). DNG is carrying out the PhD degree in the Graduate
   Program in Health Sciences (PPGCS/UFS). We also thank teacher Abilio
   Borghi for the grammar review of the manuscript and Smart Servier
   Medical Art (https://smart.servier.com/) for the images used to create
   the graphical abstract.
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NR 160
TC 28
Z9 33
U1 0
U2 41
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2019
VL 58
AR 152766
DI 10.1016/j.phymed.2018.11.026
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA IF4JH
UT WOS:000473047100009
PM 31005719
DA 2026-01-16
ER

PT J
AU Chiu, HY
   Hsieh, YJ
   Tsai, PS
AF Chiu, H. Y.
   Hsieh, Y. J.
   Tsai, P. S.
TI Systematic review and meta-analysis of acupuncture to reduce
   cancer-related pain
SO EUROPEAN JOURNAL OF CANCER CARE
LA English
DT Review
DE acupuncture; cancer-related pain; meta-analysis
ID QUALITY-OF-LIFE; NEUROPATHIC PAIN; CONTROLLED-TRIAL; ELECTROACUPUNCTURE;
   MANAGEMENT; SYMPTOMS; BIAS; CARE
AB We conducted a systematic review and meta-analysis to evaluate the effects of acupuncture on malignancy-related, chemotherapy (CT)-or radiation therapy (RT)-induced, surgery-induced, and hormone therapy (HT)induced pain. Randomised controlled trials (RCTs) examining the effects of acupuncture on cancer-related pain were reached from the EMBASE, PubMed, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, Airiti library, Taiwan Electrical Periodical Service, Wanfang Data (a Chinese database) and China Knowledge Resource Integrated Database from inception through June 2014. Heterogeneity, moderator analysis, publication bias and risk of bias associated with the included studies were examined. A total of 29 RCTs yielding 36 effect sizes were included. The overall effect of acupuncture on cancer-related pain was -0.45 [95% confidence interval (CI) = -0.63 to -0.26]. The subanalysis indicated that acupuncture relieved malignancy-related and surgery-induced pain [effect size (g) = -0.71, and -0.40; 95% CI = -0.94 to -0.48, and -0.69 to -0.10] but not CT-or RT-induced and HT-induced pain (g = -0.05, and -0.64, 95% CI = -0.33 to 0.24, and -1.55 to 0.27). Acupuncture is effective in relieving cancer-related pain, particularly malignancy-related and surgery-induced pain. Our findings suggest that acupuncture can be adopted as part of a multimodal approach for reducing cancer-related pain.
C1 [Chiu, H. Y.; Hsieh, Y. J.; Tsai, P. S.] Taipei Med Univ, Coll Nursing, Sch Nursing, 250 Wu Hsing St, Taipei 110, Taiwan.
C3 Taipei Medical University
RP Tsai, PS (corresponding author), Taipei Med Univ, Coll Nursing, Sch Nursing, 250 Wu Hsing St, Taipei 110, Taiwan.
EM ptsai@tmu.edu.tw
RI Tsai, Pei-Shan/AFS-2869-2022
OI Chiu, Hsiao-Yean/0000-0002-6419-9309
FU Ministry of Science and Technology, Taiwan [NSC 102-2628-B-038-004-MY3,
   MOST103-2314-B-038-068-MY2]
FX This meta-analysis was supported by a grant awarded to P.S. Tsai grant
   no. NSC 102-2628-B-038-004-MY3 and to H.Y. Chiu (grant no.
   MOST103-2314-B-038-068-MY2) by the Ministry of Science and Technology,
   Taiwan.
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NR 64
TC 101
Z9 109
U1 0
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0961-5423
EI 1365-2354
J9 EUR J CANCER CARE
JI Eur. J. Cancer Care
PD MAR
PY 2017
VL 26
IS 2
AR e12457
DI 10.1111/ecc.12457
PG 17
WC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
GA EO1KP
UT WOS:000396457700019
PM 26853524
DA 2026-01-16
ER

PT J
AU Liao, CX
   Tao, SY
   Xiong, Y
   Dai, JY
   Bai, Y
   Wang, X
   Li, Y
   Wu, P
AF Liao, Chenxi
   Tao, Siyu
   Xiong, Yan
   Dai, Jingyang
   Bai, Yu
   Wang, Xue
   Li, Yuan
   Wu, Ping
TI The Effects and Potential Mechanisms of Moxibustion for Rheumatoid
   Arthritis-Related Pain: A Randomized, Controlled Trial
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE moxibustion; rheumatoid arthritis; pain; inflammatory factor
ID QUALITY-OF-LIFE; AMERICAN-COLLEGE; ACUPUNCTURE; DEFINITION; VALIDATION;
   ACTIVATION; EXPRESSION; MANAGEMENT; CYTOKINES; SCORES
AB Purpose: To investigate the effects of moxibustion in relieving pain, and other clinical symptoms for patients with rheumatoid arthritis (RA), and explore the potential mechanism of moxibustion treatment for RA.Patients and Methods: Seventy qualified RA patients were randomly assigned in a 1:1 ratio to the moxibustion group or the routine group. The routine group only took oral methotrexate tablets and folic acid tablets. The moxibustion group was treated with moxibustion based on oral pharmaceutical. Moxibustion was performed two times weekly for 8 weeks, a total of 16 sessions. Patients scored their pain on a visual analog scale (VAS). The American College of Rheumatology improvement criteria of 20%, 50% and 70% (ACR20, ACR50 and ACR70) after treatment were investigated. Clinical symptoms, a disease activity score using 28 joint counts (DAS28), simplified disease activity index (SDAI), clinical disease activity index (CDAI), health assessment questionnaire (HAQ), interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) of RA patients were analyzed before and after treatment.Results: After treatment, the VAS scores, tender and swollen joint counts, morning stiffness scores, disease activity scores (DAS28, SDAI, CDAI), HAQ scores in the two groups were both improved, and the effects of moxibustion group were more obvious (P < 0.05). The ACR20 and ACR50 of the moxibustion group were greater than that of the routine group (P < 0.05), no significant difference of the ACR70 existed between the two groups (P > 0.05). In addition, the decreases of IL-1 beta, TNF-alpha, VEGF of the moxibustion group were better than that of the routine group (P < 0.05).Conclusion: Moxibustion could effectively relieve pain, ameliorate the clinical symptoms, and decrease the disease activity of RA. The potential mechanism may be the decrease in the level of serum inflammatory factors.
C1 [Liao, Chenxi; Tao, Siyu; Wang, Xue; Wu, Ping] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
   [Xiong, Yan] Sichuan Univ, Huaxi Hosp 4, Dept Osteoporosis, Chengdu, Peoples R China.
   [Dai, Jingyang] Chengdu Fifth Peoples Hosp, Dept Tradit Chinese Med, Chengdu, Peoples R China.
   [Bai, Yu] Chengdu Second Peoples Hosp, Dept Tradit Chinese Med, Chengdu, Peoples R China.
   [Li, Yuan] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Dept Rheumatol, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Sichuan University;
   Chengdu University of Traditional Chinese Medicine
RP Wu, P (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
EM wuping_33@163.com
OI Liao, Chenxi/0000-0002-0572-5567
FU National Natural Science Foundation of China [81373738]; Education
   Department of Sichuan Province [2017JY0016, 2022YFS0386]
FX Funding This study was supported by The National Natural Science
   Foundation of China (81373738) and the Education Department of Sichuan
   Province (2017JY0016 and 2022YFS0386) .
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NR 57
TC 4
Z9 7
U1 3
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 1739
EP 1749
DI 10.2147/JPR.S408814
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA I3YO8
UT WOS:001002171300001
PM 37261035
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Gao, Y
   Ma, TT
   Han, M
   Yu, MW
   Wang, XH
   Lv, YR
   Wang, XM
AF Gao, Yu
   Ma, Tingting
   Han, Mei
   Yu, Mingwei
   Wang, Xiuhui
   Lv, Yiren
   Wang, Xiaomin
TI Effects of Acupuncture and Moxibustion on Breast Cancer-Related
   Lymphedema: A Systematic Review and Meta-Analysis of Randomized
   Controlled Trials
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; moxibustion; breast cancer-related lymphedema
AB Objective: The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to evaluate the effects of acupuncture and moxibustion (AM) in women with breast cancer-related lymphedema (BCRL). Methods: We retrieved RCTs published before January 24, 2021, from the MEDLINE, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (VIP), and Wanfang databases. RCTs that compared acupuncture and/or moxibustion intervention with other treatments were included. A random effects or fixed effects model was used based on the heterogeneity findings. Study quality was evaluated using the Cochrane risk of bias tool. Results: We included 14 RCTs in the analyses, of which 4 RCTs adopted acupuncture, 4 RCTs used moxibustion, and the rest used both. AM significantly reduced arm circumference at the elbow crease compared to routine care (Mean deviation (MD) = -7.26, 95% confidence interval (CI) = -8.30 to -6.21, P < .00001). There was a significant difference between AM and diosmin tablets in the effective index for upper limb lymphedema (MD = 24.68, 95% CI = 24.82-30.53, P < .00001), the range of motion of the shoulder during protraction (MD = 6.77, 95% CI = 2.81-10.73, P = .0008), and adduction (MD = 4.17, 95% CI = 1.02-7.32, P = .01). There was a significant difference between moxibustion and pneumatic circulation (MD = -0.51, 95% CI = -0.85 to -0.17, P = .003) in the visual analog score (VAS) for swelling. Finally, compared to the blank control, acupuncture reduced the VAS for pain (MD = -1.33, 95% CI = -1.52 to -1.15, P < .00001; heterogeneity (I-2) = 0%, P = .57). Conclusion: Our results suggest that AM is effective in the treatment of BCRL. AM may reduce arm circumference at the elbow crease (compared to routine care), increase effective index for upper limb lymphedema (compared to oral diosmin tablets), improve the range of motion of the shoulder during protraction and adduction (compared to oral diosmin tablets), and decrease the VAS for both swelling (compared to pneumatic circulation) and pain (compared to blank control).
C1 [Gao, Yu; Ma, Tingting; Yu, Mingwei; Wang, Xiuhui; Lv, Yiren; Wang, Xiaomin] Capital Med Univ, Beijing Hosp Tradit Chinese Med, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
   [Han, Mei] Beijing Univ Chinese Med, Beijing, Peoples R China.
C3 Capital Medical University; Beijing University of Chinese Medicine
RP Wang, XM (corresponding author), Capital Med Univ, Beijing Hosp Tradit Chinese Med, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
EM wangxiaomin_bhtcm@126.com
OI Wang, Xiao-min/0000-0003-1274-224X
FU Beijing Science and Technology Plan Project [Z191100008319006]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by a grant (No. Z191100008319006) from Beijing Science and
   Technology Plan Project.
CR [Anonymous], 2012, Chin J Clin Res
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NR 36
TC 10
Z9 11
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2021
VL 20
AR 15347354211044107
DI 10.1177/15347354211044107
PG 13
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA UU3EJ
UT WOS:000698682300001
PM 34521235
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Xu, DH
   Yu, ZB
   Cai, XM
   Lin, JT
   Lin, TJ
   Sun, J
   Liu, ZX
   Cao, Y
   He, YH
AF Xu, Danghan
   Yu, Zhanbo
   Cai, Ximin
   Lin, Jietao
   Lin, Tengjiao
   Sun, Jian
   Liu, Zhaoxi
   Cao, Yang
   He, Yihan
TI Effect of Fu's subcutaneous needling for cancer pain management:
   protocol for a pragmatic randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE Cancer pain; COMPLEMENTARY MEDICINE; PAIN MANAGEMENT
ID ACUPUNCTURE; SHAM
AB Introduction Pain is a common symptom in patients with cancer, and pain management is crucial for these patients. Fu's subcutaneous needling (FSN) is a modern acupuncture therapy based on basic medicine commonly used in patients with pain. However, evidence of its effectiveness in treating cancer pain has not been systematically proven. Therefore, this pragmatic randomised controlled trial aims to evaluate the effectiveness and safety of FSN for cancer pain management.
   Methods and analysis Overall, 120 eligible patients will be recruited and randomly assigned into two groups using block randomisation. Both groups will be administered analgesic drugs according to the National Comprehensive Cancer Network guidelines. The treatment group will receive FSN therapy one time a day for 6 days. Additionally, we will assess analgesic consumption as the primary outcome and the Numerical Rating Scale, outbreak pain, symptom assessment and adverse events as secondary outcomes to evaluate the effect and safety of FSN in treating cancer pain. The incidence of adverse events will be monitored to assess the safety of FSN.
   Ethics and dissemination Ethics approval was obtained from the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine (approval No: K(2021)096). The results will be published in a peer-reviewed journal, and trial participants will be informed via email and/or phone calls.
C1 [Xu, Danghan] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Rehabil Ctr, Guangzhou, Guangdong, Peoples R China.
   [Yu, Zhanbo; Cai, Ximin; Liu, Zhaoxi] Guangzhou Univ Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [Lin, Jietao; Cao, Yang] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Ctr Oncol, Guangzhou, Guangdong, Peoples R China.
   [Lin, Tengjiao] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Radiotherapy, Guangzhou, Guangdong, Peoples R China.
   [Sun, Jian] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Acad Chinese Med Sci, Acupuncture Dept, Guangzhou, Guangdong, Peoples R China.
   [He, Yihan] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Acad Chinese Med Sci, Oncol Dept, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine
RP He, YH (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Acad Chinese Med Sci, Oncol Dept, Guangzhou, Guangdong, Peoples R China.
EM yihanhe@gzucm.edu.cn
RI Lin, Jietao/GXF-2015-2022; Xu, Danghan/P-1067-2018; yu,
   ivan/KBP-8004-2024
OI He, Yihan/0000-0002-4833-0231
FU Guangdong Provincial Key Laboratory of Traditional Chinese Medicine and
   Acupuncture [06]; National Natural Science Foundation of China
   [82004447]; Guangdong Basic and Applied Basic Research Foundation
   [2021A1515011597]; Guangdong Provincial Hospital of Chinese Medicine
   [YN2018QL04]
FX This work is supported by the Guangdong Provincial Key Laboratory of
   Traditional Chinese Medicine and Acupuncture (06), National Natural
   Science Foundation of China (no. 82004447), Guangdong Basic and Applied
   Basic Research Foundation (no. 2021A1515011597) and the Specific
   Research Fund for TCM Science and Technology (no. YN2018QL04) from the
   Guangdong Provincial Hospital of Chinese Medicine.
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NR 32
TC 2
Z9 2
U1 2
U2 15
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2023
VL 13
IS 4
AR e068232
DI 10.1136/bmjopen-2022-068232
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q5MG1
UT WOS:001057956000068
PM 37105691
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tian, SX
   Xu, T
   Shi, RY
   Cai, YQ
   Wu, MH
   Zhen, SJ
   Wang, W
   Zhou, Y
   Du, JY
   Fang, JF
   Shao, XM
   Liu, BY
   Jiang, YL
   He, XF
   Fang, JQ
   Liang, Y
AF Tian, Shu-Xin
   Xu, Ting
   Shi, Ren-Yi
   Cai, Yang-Qian
   Wu, Ming-Hui
   Zhen, Si-Jia
   Wang, Wen
   Zhou, You
   Du, Jun-Ying
   Fang, Jun-Fan
   Shao, Xiao-Mei
   Liu, Bo-Yi
   Jiang, Yong-Liang
   He, Xiao-Fen
   Fang, Jian-Qiao
   Liang, Yi
TI Analgesic effect of electroacupuncture on bone cancer pain in rat model:
   the role of peripheral P2X3 receptor
SO PURINERGIC SIGNALLING
LA English
DT Article
DE Electroacupuncture; Bone cancer-induced pain; P2X3 receptor; DRG
ID DORSAL-ROOT GANGLION; P2X(3) RECEPTOR; ACUPUNCTURE; TRAFFICKING;
   HYPERSENSITIVITY; SENSITIZATION; CONTRIBUTES; ACTIVATION; EXPRESSION;
   BLOCKADE
AB Upregulation of P2X3 receptor (P2X3R) has been strongly implicated in nociceptive signaling including bone cancer pain (BCP). The present study, using rat bone cancer model, aimed to explore the role of P2X3R in regulating rat pain behavior under the intervention of electroacupuncture (EA). The BCP model was successfully established by injection with MRMT-1 breast cancer cell into the medullary cavity of left tibia for 3 x 10(4) cells/3 mu L PBS in rats as revealed by obvious bone destruction, decreased paw withdrawal thresholds (PWTs), and reduced paw withdrawal latencies (PWLs). Western blot analyses showed that P2X3R expression was significantly upregulated in ipsilateral lumbar 4-6 (L4-6) dorsal root ganglia (DRG), but the difference not seen in spinal cord dorsal horn (SCDH). With the in-depth study of P2X3R activation, we observed that intrathecal injection of P2X3R agonist alpha,beta-meATP aggravated MRMT-1 induced BCP, while injection of P2X3R inhibitor A-317491 alleviated pain. Subsequently, we demonstrated that BCP induced mechanical allodynia and thermal hyperalgesia were attenuated after EA treatment. Under EA treatment, total P2X3R protein expression in ipsilateral DRGs was decreased, and it is worth mentioning that decreased expression of P2X3R membrane protein, which indicated that both the expression and membrane trafficking of P2X3R were inhibited by EA. The immunofluorescence assay showed that EA stimulation exerted functions by reducing the expression of P2X3R-positive cells in ipsilateral DRGs of BCP rats. Ca2+ imaging analysis revealed that the EA stimulation decreased the percentage of alpha,beta-meATP responsive neurons in DRGs and inhibited calcium influx. Notably, the inhibitory effect of EA on mechanical allodynia and nociceptive flinches was abolished by intrathecal injection of alpha,beta-meATP. These findings demonstrated EA stimulation ameliorated mechanical allodynia and thermal hyperalgesia in rat model of MRMT-1-induced BCP. EA exerts analgesic effect on BCP by reducing the overexpression and functional activity of P2X3R in ipsilateral DRGs of BCP rats. Our work first demonstrates the critical and overall role of P2X3R in EA's analgesia against peripheral sensitization of MRMT-1-induced BCP and further supports EA as a potential therapeutic option for cancer pain in clinic.
C1 [Tian, Shu-Xin; Xu, Ting; Cai, Yang-Qian; Wu, Ming-Hui; Zhen, Si-Jia; Wang, Wen; Zhou, You; Du, Jun-Ying; Fang, Jun-Fan; Shao, Xiao-Mei; Liu, Bo-Yi; Jiang, Yong-Liang; He, Xiao-Fen; Fang, Jian-Qiao; Liang, Yi] Zhejiang Chinese Med Univ, Sch Clin Med 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
   [Shi, Ren-Yi] Sanya Tradit Chinese Med Hosp, Dept Acupuncture & Moxibust, Sanya 572000, Peoples R China.
   [Fang, Jian-Qiao; Liang, Yi] Chinese Med Univ, Affiliated Hosp Zhejiang 3, Dept Acupuncture & Moxibust, Hangzhou 310005, Peoples R China.
C3 Zhejiang Chinese Medical University; China Medical University
RP Liang, Y (corresponding author), Zhejiang Chinese Med Univ, Sch Clin Med 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.; Liang, Y (corresponding author), Chinese Med Univ, Affiliated Hosp Zhejiang 3, Dept Acupuncture & Moxibust, Hangzhou 310005, Peoples R China.
EM liangyiwww@126.com
RI Du, Junying/AEV-3719-2022; Zhou, You/IAP-9837-2023
OI Fang, Jianqiao/0000-0002-5155-8544
FU National Natural Science Foundation of China [82174510, 81674061];
   Zhejiang Provincial Natural Science Funds [LGF21H270006]; Key Foundation
   of the Zhejiang Health Committee [2021ZZ017]
FX This research was funded by National Natural Science Foundation of China
   (82174510 and 81674061), by Zhejiang Provincial Natural Science Funds
   (LGF21H270006), and by the Key Foundation of the Zhejiang Health
   Committee (2021ZZ017).
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NR 52
TC 15
Z9 20
U1 2
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1573-9538
EI 1573-9546
J9 PURINERG SIGNAL
JI Purinergic Signal.
PD MAR
PY 2023
VL 19
IS 1
SI SI
BP 13
EP 27
DI 10.1007/s11302-022-09861-7
EA APR 2022
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 9O3UP
UT WOS:000794879900002
PM 35478452
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Liou, KT
   Trevino, KM
   Meghani, SH
   Li, QS
   Deng, G
   Korenstein, D
   Mao, JJ
AF Liou, Kevin T.
   Trevino, Kelly M.
   Meghani, Salimah H.
   Li, Q. Susan
   Deng, Gary
   Korenstein, Deborah
   Mao, Jun J.
TI Fear of analgesic side effects predicts preference for acupuncture: a
   cross-sectional study of cancer patients with pain in the USA
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Cancer; Pain management; Barriers; Preference; Acupuncture; Analgesics;
   Opioids
ID ALTERNATIVE MEDICINE USE; EDUCATIONAL INTERVENTIONS; AFRICAN-AMERICANS;
   OPIOID ANALGESICS; BARRIERS; MANAGEMENT; SURVIVORS; COMPLEMENTARY;
   OUTPATIENTS; PREVALENCE
AB Purpose Approximately one in two cancer patients globally are under-treated for pain. Opioids and other analgesics represent the mainstay of cancer pain management; however, barriers to their use are well-documented. We evaluated whether acupuncture would be a preferable treatment option among cancer patients with attitudinal barriers to pharmacological pain management. Methods We conducted a cross-sectional survey of cancer patients at a tertiary urban cancer center and eleven suburban/rural hospitals in the Northeastern United States. We assessed attitudinal barriers to pharmacological pain management with the Barriers Questionnaire (BQ-13). The BQ-13 consists of two subscales: pain management beliefs and analgesic side effects. We also asked patients whether they prefer acupuncture, analgesics, or have no preference between these two modalities for pain management. Covariates included sociodemographics, clinical characteristics, and attitudes/beliefs about acupuncture. We used logistic regression to examine the association between attitudinal barriers and acupuncture preference. Results Among 628 patients, 197 (31.4%) preferred acupuncture for pain management, 146 (23.3%) preferred analgesics, and 285 (45.4%) had no preference. The highest reported attitudinal barriers were fear of addiction and fear of analgesic-associated constipation and nausea. Adjusting for covariates, we found that attitudinal barriers related to fear of analgesic side effects were significantly associated with acupuncture preference (adjusted odds ratio [AOR] 1.45, 95% confidence interval [CI] 1.17-1.81), but barriers related to pain management beliefs were not (AOR 1.17, 95% CI 0.91-1.51). Attitudes/beliefs about acupuncture (i.e., greater expected benefits, fewer perceived barriers, and more positive social norms) and female gender also predicted acupuncture preference, whereas race and educational status did not. Conclusion Acupuncture may be a preferable treatment option among cancer patients at risk of inadequately controlled pain due to fear of analgesic side effects. Evidence-based integration of acupuncture and analgesics, guided by patient treatment preferences, represents an essential aspect of patient-centered care and has potential to address unmet cancer pain management needs.
C1 [Liou, Kevin T.; Li, Q. Susan; Deng, Gary; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
   [Liou, Kevin T.; Deng, Gary; Mao, Jun J.] Weill Cornell Med, Dept Med, New York, NY 10065 USA.
   [Trevino, Kelly M.] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10021 USA.
   [Meghani, Salimah H.] Univ Penn, Sch Nursing, Dept Biobehav Hlth Sci, Philadelphia, PA 19104 USA.
   [Korenstein, Deborah] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
   [Korenstein, Deborah] Mem Sloan Kettering Canc Ctr, Ctr Hlth Policy & Outcomes, 1275 York Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Cornell University; Weill
   Cornell Medicine; Memorial Sloan Kettering Cancer Center; University of
   Pennsylvania; Memorial Sloan Kettering Cancer Center; Memorial Sloan
   Kettering Cancer Center
RP Liou, KT (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.; Liou, KT (corresponding author), Weill Cornell Med, Dept Med, New York, NY 10065 USA.
EM liouk@mskcc.org
OI Liou, Kevin/0000-0002-2438-9749; Meghani, Salimah/0000-0002-5866-8279
FU National Cancer Institute [2P30CA01652040, 3P30CA00874850]; Byrne Fund;
   Translational and Integrative Medicine Research Fund at Memorial Sloan
   Kettering Cancer Center; National Cancer Institute [P30CA008748,
   P30CA016520] Funding Source: NIH RePORTER
FX Research related to the development of this paper was supported in part
   by the National Cancer Institute grants to the University of
   Pennsylvania Abramson Cancer Center (2P30CA01652040) and the Memorial
   Sloan Kettering Cancer Center (3P30CA00874850), the Byrne Fund, and the
   Translational and Integrative Medicine Research Fund at Memorial Sloan
   Kettering Cancer Center.
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NR 54
TC 24
Z9 29
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JAN
PY 2021
VL 29
IS 1
BP 427
EP 435
DI 10.1007/s00520-020-05504-y
EA MAY 2020
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA RI9WR
UT WOS:000530959400001
PM 32383073
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Guo, ZN
   Wang, LY
   Wang, YT
   Liu, WH
   Zhao, Y
   Tang, XR
   Lin, R
   Wu, ZN
   Cui, SY
   Xu, NG
AF Guo, Zining
   Wang, Liying
   Wang, Yuting
   Liu, Wenhao
   Zhao, Yi
   Tang, Xiaorong
   Lin, Run
   Wu, Zhennan
   Cui, Shaoyang
   Xu, Nenggui
TI Acupuncture for cancer-related insomnia: An evidence mapping
SO INTEGRATIVE MEDICINE RESEARCH
LA English
DT Review
DE Acupoint; Acupuncture; Cancer; Evidence mapping; Insomnia
ID SLEEP DISTURBANCES; SEVERITY INDEX; CHEMOTHERAPY; ACUPRESSURE;
   DEPRESSION; VALIDATION; MANAGEMENT; FATIGUE; PAIN
AB Background: Acupuncture shows promise in treating cancer-related insomnia (CRI); however, the evidence level for its effectiveness remains low. This study systematically examined research quality and used evidence mapping (EM) to map and present evidence information to identify gaps and inform future research. Methods: Two reviewers searched eight databases from inception to May 2024, screened eligible randomized controlled trials (RCTs), and extracted key characteristics from included studies. The quality of studies was assessed using the Cochrane Risk of Bias 2.0 (RoB 2.0) tool, and key characteristics visualized EM. Finally, Acupoint data were systematically summarized. Results: 37 RCTs were included in this study. RoB 2.0 results showed only three studies at "low risk," while most had notable quality issues. EM indicated that common comparisons involved manual acupuncture (MA), alone or combined, versus sleep medications. Measures involved six assessment tools, with Pittsburgh Sleep Quality Index (PSQI) most frequently used. Meanwhile, EM revealed considerable uncertainty regarding acupuncture for CRI efficacy. Acupoint analysis identified Yintang (GV24 +), Shenting (GV24), Baihui (GV20), Sanyinjiao (SP6), Neiguan (PC6), and Shenmen (HT7) as core acupoints. Analysis identified five key gaps: study reliability, participant selection, placebo effect, outcome measurement, and acupoint selection. Conclusions: Research on acupuncture for CRI has various gaps, and more high-quality evidence is still needed. This study comprehensively mapped the current evidence on acupuncture for CRI and identified five key gaps, providing directions and references for future research. Protocol registration: INPLASY, INPLASY202460052.
C1 [Guo, Zining; Wang, Liying; Lin, Run; Cui, Shaoyang] Guangzhou Univ Chinese Med, Shenzhen Hosp Fu Tian, Shenzhen, Peoples R China.
   [Wang, Yuting; Liu, Wenhao; Zhao, Yi; Tang, Xiaorong; Wu, Zhennan; Xu, Nenggui] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou 510000, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Xu, NG (corresponding author), Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou 510000, Peoples R China.; Cui, SY (corresponding author), Guangzhou Univ Chinese Med, Shenzhen Hosp, Shenzhen 518000, Guangdong, Peoples R China.
EM herb107@126.com; ngxu8018@163.com
RI ; Wu, Zhennan/NTQ-6878-2025; Guo, Zining/OGN-4300-2025
OI Wang, Liying/0000-0002-4631-1766; cui, shaoyang/0000-0001-6723-7465; 
FU Sanming Project of Medicine in Shenzhen [SZZYSM202311011]; Guangzhou
   University of Traditional Chinese Medicine Joint Science and Technology
   Innovation Fund [GZYFT2024Y09]; Basic and Applied Basic Research Program
   of Guangzhou Municipal Health Commission Foundation [SL2022A03J00189]
FX This work was supported by the Sanming Project of Medicine in Shenzhen
   (No. SZZYSM202311011), Guangzhou University of Traditional Chinese
   Medicine Joint Science and Technology Innovation Fund (GZYFT2024Y09) and
   the Basic and Applied Basic Research Program of Guangzhou Municipal
   Health Commission Foundation (No. SL2022A03J00189).
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NR 94
TC 0
Z9 0
U1 12
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4220
EI 2213-4239
J9 INTEGR MED RES
JI Integr. Med. Res.
PD DEC
PY 2025
VL 14
IS 4
AR 101225
DI 10.1016/j.imr.2025.101225
EA AUG 2025
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6SB5S
UT WOS:001560670800001
PM 40896346
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lee, JW
   Lee, WB
   Kim, W
   Min, BI
   Lee, H
   Cho, SH
AF Lee, Jung-Woo
   Lee, Won Bock
   Kim, Woojin
   Min, Byung-Il
   Lee, HyangSook
   Cho, Seung-Hun
TI Traditional herbal medicine for cancer pain: A systematic review and
   meta-analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Traditional herbal medicine; Cancer pain; Systematic review;
   Meta-analysis
ID RANDOMIZED CONTROLLED-TRIALS; QUALITY-OF-LIFE; ACUPUNCTURE TREATMENT
AB Background: The effectiveness of traditional herbal medicine (THM) as an adjunctive therapy for cancer pain is unclear.
   Objective: To assess the effectiveness of THM as an adjunctive therapy for cancer pain using randomized controlled trials (RCTs).
   Methods: Five electronic databases, including those from the UK and China, were systematically searched for the period before September 2013. All RCTs involving the use of THM in combination with conventional cancer therapy for cancer pain were included.
   Results: Twenty-four RCTs involving 4889 patients with cancer pain were systematically reviewed. Among them, nine studies of 952 patients reported a significant decrease in the number of patients with cancer pain in the treatment group. Four studies of 1696 patients reported a significant decrease in the degree of pain in the treatment group.
   Conclusion: The results of these studies suggest that THM combined with conventional therapy is efficacious as an adjunctive therapy for patients with cancer pain. However, more research, including well-designed, rigorous, and larger clinical trials, are necessary to address these issues. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Lee, Jung-Woo; Lee, Won Bock; Kim, Woojin; Min, Byung-Il] Kyung Hee Univ, Grad Sch, Dept East West Med, Seoul 130701, South Korea.
   [Min, Byung-Il] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea.
   [Lee, HyangSook] Kyung Hee Univ, Coll Korean Med, Acupuncture & Meridian Sci Res Ctr, Seoul 130701, South Korea.
   [Cho, Seung-Hun] Kyung Hee Univ, Med Ctr, Hosp Korean Med, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University; Kyung Hee University Hospital
RP Cho, SH (corresponding author), Kyung Hee Univ, Med Ctr, Hosp Korean Med, 1 Heogi Dong, Seoul 130701, South Korea.
EM chosh@khmc.or.kr
RI Cho, Seung-Hun/F-1294-2010; LEE, HYANGSOOK/D-2070-2017; MIN, B.
   I./U-3364-2017; Kim, Woojin/AAK-2464-2020
OI Cho, Seung-Hun/0000-0002-0627-768X; LEE, HYANGSOOK/0000-0002-1107-9389; 
FU National Research Foundation of Korea (NRF) - Korea government [MEST]
   [2012-0005755]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government [MEST] (No. 2012-0005755).
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NR 37
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Z9 32
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD APR
PY 2015
VL 23
IS 2
BP 265
EP 274
DI 10.1016/j.ctim.2015.02.003
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CH0TE
UT WOS:000353734500016
PM 25847565
DA 2026-01-16
ER

PT J
AU Hu, CQ
   Zhang, HB
   Wu, WY
   Yu, WQ
   Li, Y
   Bai, JP
   Luo, BH
   Li, SP
AF Hu, Caiqiong
   Zhang, Haibo
   Wu, Wanyin
   Yu, Weiqing
   Li, Yong
   Bai, Jianping
   Luo, Baohua
   Li, Shuping
TI Acupuncture for Pain Management in Cancer: A Systematic Review and
   Meta-Analysis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID ELECTROACUPUNCTURE; EXPRESSION
AB Objective. To evaluate the effectiveness and safety of acupuncture for cancer-related pain. Methods. Asystematic review of literatures published from database inception to February 2015 was conducted in eight databases. RCTs involving acupuncture for treatment of cancer-related pain were identified. Two researchers independently performed article selection, data extraction, and quality assessment of data. Results. 1,639 participants in twenty RCTs were analyzed. All selected RCTs were associated with high risk of bias. Meta-analysis indicated that acupuncture alone did not have superior pain-relieving effects as compared with conventional drug therapy. However, as compared with the drug therapy alone, acupuncture plus drug therapy resulted in increased pain remission rate, shorter onset time of pain relief, longer pain-free duration, and better quality of life without serious adverse effects. However, GRADE analysis revealed that the quality of all outcomes about acupuncture plus drug therapy was very low. Conclusions. Acupuncture plus drug therapy is more effective than conventional drug therapy alone for cancer-related pain. However, multicenter high-quality RCTs with larger sample sizes are needed to provide stronger evidence for the effectiveness of acupuncture in cancer-related pain due to the low data quality of the studies included in the current meta-analysis.
C1 [Hu, Caiqiong; Yu, Weiqing; Luo, Baohua; Li, Shuping] Guangzhou Univ Chinese Med, Sch Clin Med 2, Guangzhou 510405, Guangdong, Peoples R China.
   [Zhang, Haibo; Wu, Wanyin; Li, Yong; Bai, Jianping] Guangdong Prov Hosp Chinese Med, Dept Oncol, Guangzhou 510120, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zhang, HB (corresponding author), Guangdong Prov Hosp Chinese Med, Dept Oncol, Guangzhou 510120, Guangdong, Peoples R China.
EM haibozh@aliyun.com
RI Zhang, Haibo/HLP-9266-2023
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NR 47
TC 64
Z9 71
U1 1
U2 25
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 1720239
DI 10.1155/2016/1720239
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DE5WM
UT WOS:000370703900001
PM 26977172
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Bae, K
   Yoo, HS
   Lamoury, G
   Boyle, F
   Rosenthal, DS
   Oh, B
AF Bae, Kyeore
   Yoo, Hwa-Seung
   Lamoury, Gillian
   Boyle, Frances
   Rosenthal, David S.
   Oh, Byeongsang
TI Acupuncture for Aromatase Inhibitor-Induced Arthralgia: A Systematic
   Review
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; breast cancer; aromatase inhibitors; arthralgia; joint
   pain; pain management
ID EARLY BREAST-CANCER; ADJUVANT ENDOCRINE THERAPY; JOINT SYMPTOMS;
   RISK-FACTORS; MUSCULOSKELETAL SYMPTOMS; RANDOMIZED-TRIALS; AMERICAN
   SOCIETY; PAIN; WOMEN; MANAGEMENT
AB Background. Aromatase inhibitors (AIs) are commonly used as adjunctive hormone treatment for early breast cancer patients. The major side effect of AIs is arthralgia, which affects adherence. Previous reviews suggested that acupuncture is effective in the management of cancer-related pain. The aim of this review is to evaluate the effects of acupuncture on arthralgia caused by AIs. Methods. This article examined randomized controlled trials (RCTs) measuring the effects of acupuncture on joint symptoms caused by AIs within 8 medical databases till May 2014. The quality of the articles was evaluated according to the Cochrane risk of bias (ROB) tool. Results. Four RCTs were identified in medical journals. Two studies were conducted with manual acupuncture and 2 studies were electroacupuncture. The range of sample size was between 32 and 67. One RCT showed significant improvement in the acupuncture group compared with the sham control group and another RCT showed a statistical difference between the electroacupuncture and waitlist group. The other 2 studies showed no statistical differences between control and acupuncture groups. Two studies conducted blood analysis to elucidate the mechanism of efficacy of acupuncture for arthralgia. The 2 positive studies had a lower ROB and 2 studies had a high ROB. Conclusions. The systematic review suggests that acupuncture has potential benefits to improve arthralgia caused by AIs. However, further trials of adequate sample size, appropriate control group, and longer follow-up are necessary to investigate the efficacy of acupuncture in AI-induced arthralgia.
C1 [Bae, Kyeore; Lamoury, Gillian; Oh, Byeongsang] Royal N Shore Hosp, Sydney Med Sch, Sydney, NSW, Australia.
   [Bae, Kyeore; Yoo, Hwa-Seung] Daejeon Univ, Dunsan Korean Med Hosp, East West Canc Ctr, Taejon, South Korea.
   [Lamoury, Gillian; Boyle, Frances] Mater Hosp, Sydney Med Sch, Sydney, NSW, Australia.
   [Rosenthal, David S.; Oh, Byeongsang] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA.
C3 Royal North Shore Hospital; University of Sydney; Daejeon University;
   University of Sydney; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Dana-Farber Cancer Institute
RP Bae, K (corresponding author), Daejeon Univ, Dunsan Korean Med Hosp, East West Canc Ctr, Taejon, South Korea.
EM kyeorebae@gmail.com
RI Oh, Byeongsang/ABH-1460-2020
OI Bae, Kyeore/0000-0002-8596-8293; Lamoury, Gillian/0000-0001-9290-0193
CR [Anonymous], 37 ANN SAN ANT BREAS
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NR 51
TC 33
Z9 34
U1 0
U2 27
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD NOV
PY 2015
VL 14
IS 6
BP 496
EP 502
DI 10.1177/1534735415596573
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA CT8JW
UT WOS:000363063200001
PM 26220605
OA gold
DA 2026-01-16
ER

PT J
AU Yao, CJ
   Zeng, XY
   Zhang, SP
   Xiao, B
   Sun, PP
   Kong, LJ
   Tao, JM
   Fang, M
AF Yao, Chongjie
   Zeng, Xinyu
   Zhang, Shuaipan
   Xiao, Bin
   Sun, Pingping
   Kong, Lingjun
   Tao, Jiming
   Fang, Min
TI Acupoint massage: a comprehensive descriptive review of its forms,
   applications, and underlying mechanisms
SO CHINESE MEDICINE
LA English
DT Review
DE Acupoint; Massage; Acupressure; Tuina; Mechanism
ID FOOT REFLEXOLOGY MASSAGE; QUALITY-OF-LIFE; AURICULAR ACUPRESSURE; SLEEP
   QUALITY; PLEASANT TOUCH; RAT MODEL; ACUPUNCTURE; PAIN;
   ELECTROACUPUNCTURE; ANXIETY
AB Acupoint massage is a non-invasive traditional therapy that has demonstrated reliable clinical outcomes in pain management, mental health relief, sleep disorder regulation, gastrointestinal treatment, and as an adjunct therapy for cancer. Its convenience and cost-effectiveness further enhance its appeal. However, the existing English literature lacks a systematic review that encompasses the various forms of acupoint massage. The acupoint massage forms adaptability is particularly notable when considering the diverse conditions, it addresses, as well as its applicability across different age groups and gender differences. Providing a comprehensive understanding, it is crucial to outline common practices and explore specific applications in key areas. The comprehensive understanding can create opportunities for effective collaboration between preclinical and clinical studies. Defining and categorizing different forms of acupoint massage is essential, alongside investigating the neural circuits involved in touch sensation. Future efforts should enhance collaboration with modern biology, facilitating the transition from empirical to evidence-based practice. This review summarizes forms, applications, and mechanisms of mainstream acupoint massage and provides insights for future research and applications, promoting deeper integration into healthcare.
C1 [Yao, Chongjie; Zhang, Shuaipan; Xiao, Bin; Kong, Lingjun; Tao, Jiming; Fang, Min] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China.
   [Yao, Chongjie; Zeng, Xinyu; Xiao, Bin] Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Shanghai 201203, Peoples R China.
   [Sun, Pingping] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
   [Fang, Min] Shanghai Acad Tradit Chinese Med, Res Inst Tuina, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP Tao, JM; Fang, M (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China.; Fang, M (corresponding author), Shanghai Acad Tradit Chinese Med, Res Inst Tuina, Shanghai 200437, Peoples R China.
EM taoyecheng@163.com; fm-tn0510@shutcm.edu.cn
RI Xiao, Bin/GQA-7382-2022; YAO, CHONGJIE/AAN-2979-2020
OI Xiao, Bin/0000-0001-9824-5695; 
FU National Natural Science Foundation of China [82305423, 82305424,
   82030121]; China Postdoctoral Science Foundation [2023M732338]; Shanghai
   Post-doctoral Excellence Program [2022515]; Yangfan Special Project of
   Shanghai Science and Technology Innovation Action Plan [23YF1447600];
   Shanghai health system key supported discipline [2023ZDFC0301]; Shanghai
   University of TCM Science and Technology Development Project [23
   KFL009]; Shanghai Innovative Medical Device Application Demonstration
   Project [23SHS05400]; Pudong New Area Health Commission's
   Medical-Enterprise Integration Project [2024-PWYC-03]
FX This work was supported by the National Natural Science Foundation of
   China (82305423, 82305424, 82030121), China Postdoctoral Science
   Foundation (2023M732338), Shanghai Post-doctoral Excellence Program
   (2022515), Yangfan Special Project of Shanghai Science and Technology
   Innovation Action Plan (23YF1447600), Shanghai health system key
   supported discipline (2023ZDFC0301), Shanghai University of TCM Science
   and Technology Development Project (23 KFL009), Shanghai Innovative
   Medical Device Application Demonstration Project (23SHS05400), Pudong
   New Area Health Commission's Medical-Enterprise Integration Project
   (2024-PWYC-03).
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NR 211
TC 7
Z9 7
U1 11
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD APR 23
PY 2025
VL 20
IS 1
AR 54
DI 10.1186/s13020-025-01105-1
PG 21
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 1TC3S
UT WOS:001473011900001
PM 40270014
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Baeumler, PI
   Conzen, P
   Irnich, D
AF Baeumler, Petra Iris
   Conzen, Peter
   Irnich, Dominik
TI High Temporal Summation of Pain Predicts Immediate Analgesic Effect of
   Acupuncture in Chronic Pain Patients-A Prospective Cohort Study
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE quantitative sensory testing; wind-up ratio; vibration detection
   threshold; responder; sensitization
ID GERMAN RESEARCH NETWORK; NEUROPATHIC PAIN; PRESSURE PAIN; WIND-UP;
   DIFFERENTIATE SUBGROUPS; DOUBLE-BLIND; CANCER PAIN; BACK-PAIN;
   ELECTROACUPUNCTURE; MODULATION
AB Objectives: This prospective cohort study explored whether two distinguished sensory parameters predicted acupuncture effects in chronic pain patients; namely high temporal summation of pain (TS) indicating spinal synaptic facilitation as well as a low vibration detection threshold (VDT) indicating a loss of A beta-fiber function.
   Methods: Pinprick induced TS and VDT were assessed by standardized, validated methods at the most painful body site and a pain free control site in 100 chronic pain patients receiving six acupuncture sessions as part of an interdisciplinary multimodal pain treatment (IMPT). Immediate change in pain intensity after the first acupuncture session (first treatment on the first day of IMPT) was assessed by the verbal rating scale (VRS, 0-100). After 4 weeks of treatment, patients indicated in a questionnaire whether acupuncture had relieved pain immediately and whether it had contributed to overall pain reduction and well-being after IMPT.
   Results: Logistic regression analysis revealed an association between high TS at the control site and a reduction in pain intensity of at least 30% (VRS) after the first acupuncture (OR [95%-CI] 4.3 [1.6-11.8]). Questionnaire ratings of immediate pain relief after acupuncture were associated with high TS at the control site (OR [95%-CI] 3.8 [1.4-10.2] any pain relief, OR [95%-CI] 5.5 [1.7-17.1] over 50% pain reduction) and at the pain site (OR [95%-CI] 3.2 [1.2-8.9] any pain relief). Appraisals of the contribution of acupuncture to overall pain reduction and well-being after IMPT were not associated with TS. The VDT was not associated with any outcome.
   Conclusion: This explorative study provides first-time evidence that high TS, especially at a pain free control site, but not VDT, might predict immediate analgesic response to acupuncture in chronic pain patients. Thus, highly centrally sensitized chronic pain patients might respond particularly well to acupuncture.
C1 [Baeumler, Petra Iris; Irnich, Dominik] Univ Hosp Ludwig Maximilians Univ, Multidisciplinary Pain Ctr, Dept Anaesthesiol, Munich, Germany.
   [Conzen, Peter] Univ Hosp Ludwig Maximilians Univ, Dept Anaesthesiol, Munich, Germany.
C3 University of Munich; University of Munich
RP Baeumler, PI (corresponding author), Univ Hosp Ludwig Maximilians Univ, Multidisciplinary Pain Ctr, Dept Anaesthesiol, Munich, Germany.
EM petra.baeumier@med.uni-muenchen.de
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NR 80
TC 12
Z9 17
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUL 11
PY 2019
VL 13
AR 498
DI 10.3389/fnins.2019.00498
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA II8CZ
UT WOS:000475420300001
PM 31354400
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Enblom, A
   Johnsson, A
AF Enblom, Anna
   Johnsson, Anna
TI Type and frequency of side effects during PC6 acupuncture: observations
   from therapists and patients participating in clinical efficacy trials
   of acupuncture
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE Complementary Medicine; Physiotherapy; Adverse Events; Clinical Trials;
   Acupuncture
ID CHEMOTHERAPY-INDUCED NAUSEA; POSTOPERATIVE NAUSEA; PLACEBO-ACUPUNCTURE;
   MANUAL ACUPUNCTURE; SINGLE-BLIND; CANCER; ELECTROACUPUNCTURE;
   PROPHYLAXIS; ACUPRESSURE; PREVENTION
AB Background Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general. Knowledge of side effects is central to shared decision-making.
   Aim To describe the type and frequency of side effects and the level of needle-induced pain during PC6 acupuncture.
   Methods We included 1298 PC6 acupuncture treatments, delivered to 221 participants (77% women, mean age 52.5, range 18-91 years). The subjects had received genuine PC6 acupuncture, in one of two previous randomised controlled trials, aimed at inducing antiemetic (n=100, with 100 providing data on side effects and 94 on needle-induced pain, respectively) or relaxing (n=121, with 120 providing data) effects. Side effects during and after the acupuncture treatments were registered in structured treatment protocols and study diaries.
   Results No serious complications occurred. Side effects during the acupuncture sessions included minor bleeding in 5.0%, tiredness in 4.9%, numbness in 4.5% and dizziness in 1.4% of the 1298 treatments. After treatment, the mean proportions of participants reporting side effects each week were: tiredness 25.8%; feeling cold 17.8%; dizziness 9.7%; sweating 9.3%; haematoma 8.8%; and soreness at the needling sites 4.3%. Participants perceived the needling to be not painful (47.4% of participants), or mildly (39.1%), moderately (11.6%) or very painful (1.4%).
   Conclusions Few side effects occurred and those that did were mild. Nearly 90% found PC6 acupuncture to be not painful or only mildly painful. Healthcare professionals may consider the observed levels of side effects when informing patients about side effects of PC6 acupuncture.
C1 [Enblom, Anna] Linkoping Univ, Reg Ostergotland, Linkoping, Sweden.
   [Enblom, Anna] Linkoping Univ, Dept Med & Hlth Sci, Div Physiotherapy, S-58183 Linkoping, Sweden.
   [Johnsson, Anna] Skane Univ Hosp, Dept Oncol, Lund, Sweden.
   [Johnsson, Anna] Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
C3 Linkoping University; Linkoping University; Lund University; Skane
   University Hospital; Lund University
RP Enblom, A (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, Div Physiotherapy, S-58183 Linkoping, Sweden.
EM anna.enblom@liu.se
OI Johnsson, Anna/0000-0001-9347-5336
FU Swedish Cancer Society [04 0483]; Vardal Institute; Region of
   Ostergotland [LIO-345691, LIO-613331, LIO-426011]; University of
   Linkoping [LIO-345691, LIO-613331, LIO-426011]; Cancer Rehabilitation
   Foundation [C 40111]; Osher Centrum for Integrative Medicine, Karolinska
   Institute
FX This work was supported by [The Swedish Cancer Society] grant number [04
   0483], [the Vardal Institute] grant number [N/A], [the Region of
   Ostergotland] grant number [LIO-345691, LIO-613331, LIO-426011], [The
   University of Linkoping] grant number [LIO-345691, LIO-613331,
   LIO-426011], [the Cancer Rehabilitation Foundation] grant number [C
   40111], and [the Osher Centrum for Integrative Medicine, Karolinska
   Institute] grant number [N/A].
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NR 48
TC 7
Z9 11
U1 0
U2 23
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD DEC
PY 2017
VL 35
IS 6
BP 421
EP 429
DI 10.1136/acupmed-2016-011270
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FR4QA
UT WOS:000419049100004
PM 29222203
DA 2026-01-16
ER

PT J
AU Sorensen, RW
   Andersen, NI
   Dieperink, KB
AF Sorensen, Regina Wittchen
   Andersen, Nina Ingerslev
   Dieperink, Karin Brochstedt
TI NADA Acupuncture in Specialized Palliative Care: Patients' and Family
   Caregivers' Experiences
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE NADA acupuncture; ear acupuncture; palliative care; relief of suffering;
   coping; family nursing
ID COMMUNICATION; PROTOCOL; HOSPICE; HEALTH
AB Context. Over the last 30 years, non -pharmacological treatment with ear acupuncture, including National Acupuncture Detoxi fi cation Association (NADA) acupuncture, has become popular in Western society to relieve cancer -related symptoms. Objectives. This study aim is to explore whether NADA acupuncture plays a role in relieving suffering experienced by patients hospitalized in a specialized palliative care ward and their family caregivers and whether it contributes to their coping skills. Methods. A qualitative study with a hermeneutic approach utilizing inductive thematic content analysis. Purposeful sampling took place in a specialized palliative care ward in Denmark and all data were collected through semi -structured interviews with patients and family caregivers as either individual or family interviews. Results. A total of 10 patients and 15 family caregivers participated in interviews. Four themes emerged: (1) communication about treatment with NADA acupuncture, (2) relief of suffering generates extra energy and inner strength, (3) sharing the experience with the family is bene fi cial, and (4) physical and psychological effects after receiving NADA acupuncture. Conclusion. Patients in palliative care and their family caregivers experienced relief of suffering after receiving NADA acupuncture, as well as improved well-being, and extra energy and inner strength to cope with their life situation. The ability to share NADA acupuncture gave family caregivers the feeling of being cared for and contributed to feelings of fellowship and togetherness within the family, strengthening their ability to communicate and cope. J Pain Symptom Manage 2024;68:1 - 9. (c) 2024 The Authors. Published by Elsevier Inc. on behalf of American Academy of Hospice and Palliative Medicine. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
C1 [Sorensen, Regina Wittchen; Andersen, Nina Ingerslev; Dieperink, Karin Brochstedt] Odense Univ Hosp, Dept Oncol, Sdr Blvd 29, DK-5000 Odense C, Denmark.
C3 University of Southern Denmark; Odense University Hospital
RP Sorensen, RW (corresponding author), Odense Univ Hosp, Dept Oncol, Sdr Blvd 29, DK-5000 Odense C, Denmark.
EM Regina.soerensen@rsyd.dk
OI Wittchen Sørensen, Regina/0009-0002-7847-871X; Andersen, Nina
   Ingerslev/0000-0002-8119-7970; Dieperink, Karin B/0000-0003-4766-3242
CR Beng TS, 2021, PROG PALLIAT CARE, V29, P209, DOI 10.1080/09699260.2021.1872135
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NR 31
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JUL
PY 2024
VL 68
IS 1
BP 1
EP 9
DI 10.1016/j.jpainsymman.2024.03.017
EA JUN 2024
PG 9
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA WB8S1
UT WOS:001252505300001
PM 38522805
OA Green Published, hybrid
DA 2026-01-16
ER

PT J
AU Oh, B
   Kimble, B
   Costa, DSJ
   Davis, E
   McLean, A
   Orme, K
   Beith, J
AF Oh, B.
   Kimble, B.
   Costa, D. S. J.
   Davis, E.
   McLean, A.
   Orme, K.
   Beith, J.
TI Acupuncture for treatment of arthralgia secondary to aromatase inhibitor
   therapy in women with early breast cancer: pilot study
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE COMPLEMENTARY MEDICINE; PAIN MANAGEMENT; PAIN RESEARCH; THERAPEUTICS
ID LOW-BACK-PAIN; ALTERNATIVE MEDICINE; PLACEBO ACUPUNCTURE;
   AMERICAN-SOCIETY; CONTROLLED-TRIAL; COMPLEMENTARY; ELECTROACUPUNCTURE;
   CHEMOTHERAPY; MULTICENTER; MANAGEMENT
AB Background
   Aromatase inhibitors (AIs) are recommended as adjuvant hormone treatment for postmenopausal women with early breast cancer. A substantial proportion of women taking AIs experience joint pain and stiffness. Studies have suggested that acupuncture may be effective in treating joint pain.
   Objective
   A pilot study was conducted to evaluate the feasibility, safety and efficacy of using acupuncture to treat AI-induced arthralgia.
   Methods
   A total of 32 patients were randomised to receive either sham or real electroacupuncture (EA) twice weekly for 6weeks. Outcomes of joint pain, stiffness and physical function were measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), overall pain severity and interference with the BPI-SF and quality of life (QOL) with the Functional Assessment of Cancer Therapy-General (FACT-G) instrument. Hand strength was assessed by a grip test, and a serum marker of inflammation (C reactive protein (CRP)) was also measured. All assessments were performed at baseline, 6weeks and 12weeks, except for blood samples at baseline and 6weeks only.
   Results
   No serious adverse events were reported during or after acupuncture treatments. There were no significant differences in outcome measures. However, positive trends were observed in stiffness and physical function at week 12 in favour of real EA.
   Conclusions
   Findings suggest that acupuncture is feasible and safe in patients with breast cancer with joint pain caused by AI. A larger study with adequately powered to confirm these results and detect clinically relevant effects is needed.
C1 [Oh, B.; McLean, A.; Beith, J.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Oh, B.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Kimble, B.; Orme, K.; Beith, J.] Royal Prince Alfred Hosp, Sydney Canc Ctr, Sydney, NSW, Australia.
   [Costa, D. S. J.; Davis, E.] Univ Sydney, Psychooncol Cooperat Res Grp PoCoG, Sydney, NSW 2006, Australia.
C3 University of Sydney; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute; Harvard Medical School;
   University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney
RP Davis, E (corresponding author), Univ Sydney, Psychooncol Cooperat Res Grp PoCoG, Sydney, NSW 2006, Australia.
EM esther.davis@sydney.edu.au
RI Oh, Byeongsang/ABH-1460-2020
OI Beith, Jane/0000-0002-4946-2789; Davis, Esther/0000-0002-9653-962X
FU Cancer Institute NSW Innovative Grant; Sydney South West Area Health
   Service, NSW Department of Health
FX This study was awarded the Cancer Institute NSW Innovative Grant in 2008
   and supported by the Sydney South West Area Health Service, NSW
   Department of Health.
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NR 41
TC 57
Z9 66
U1 0
U2 43
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD SEP
PY 2013
VL 31
IS 3
BP 264
EP 271
DI 10.1136/acupmed-2012-010309
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 208YU
UT WOS:000323719800002
PM 23722951
DA 2026-01-16
ER

PT J
AU Huang, CC
   Ho, TJ
   Ho, HY
   Chen, PY
   Tu, CH
   Huang, YC
   Lee, YC
   Sun, MF
   Chen, YH
AF Huang, Chien-Chen
   Ho, Tsung-Jung
   Ho, Hsin-Yueh
   Chen, Pei-Yu
   Tu, Cheng-Hao
   Huang, Yu-Chuen
   Lee, Yu-Chen
   Sun, Mao-Feng
   Chen, Yi-Hung
TI Acupuncture Relieved Chemotherapy-Induced Peripheral Neuropathy in
   Patients with Breast Cancer: A Pilot Randomized Sham-Controlled Trial
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE acupuncture; chemotherapy; peripheral neuropathy; breast cancer;
   Semmes-Weinstein monofilament; neuropathic pain
ID BRIEF PAIN INVENTORY; FUNCTIONAL-ASSESSMENT; ONCOLOGY; NEUROTOXICITY;
   VALIDATION; SAFETY; ELECTROACUPUNCTURE; STIMULATION; DULOXETINE;
   REDUCTION
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect caused by neurotoxic chemotherapy. This randomized controlled trial aimed to evaluate the effect of manual acupuncture on CIPN. Twenty eligible breast cancer patients receiving taxane chemotherapy treatment were recruited and randomly divided into verum acupuncture and sham acupuncture groups. Each group received 15 treatments over 9 weeks. Quantitative tactile detection thresholds were measured using Semmes-Weinstein monofilament testing (SWM). The World Health Organization Quality of Life scale (WHOQOL-BREF), the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the Brief Pain Inventory-Short Form (BPI-SF) were measured before and after treatment. The between-group comparison of SWM revealed that the verum acupuncture group had more improvement of touch perception thresholds compared to the sham acupuncture group. The average pain severity in the BPI-SF of the verum acupuncture group was significantly lower than that of the sham acupuncture group. There were no significant differences in the FACT/GOG-Ntx trial outcome index and WHOQOL-BREF scores between the acupuncture and sham groups. The results suggest that acupuncture can alleviate the neuropathic pain of CIPN and improve touch perception thresholds.
C1 [Huang, Chien-Chen; Lee, Yu-Chen] China Med Univ, Coll Chinese Med, Sch Chinese Med, Grad Inst Chinese Med, Taichung 40402, Taiwan.
   [Huang, Chien-Chen] China Med Univ, An Nan Hosp, Dept Tradit Chinese Med, Tainan 709, Taiwan.
   [Ho, Tsung-Jung] Hualien Tzu Chi Hosp, Dept Chinese Med, Hualien 970, Taiwan.
   [Ho, Tsung-Jung] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 970374, Taiwan.
   [Ho, Tsung-Jung] Hualien Tzu Chi Hosp, Integrat Ctr Tradit Chinese & Modern Med, Hualien 970, Taiwan.
   [Ho, Hsin-Yueh] China Med Univ, An Nan Hosp, Dept Surg, Tainan 709, Taiwan.
   [Chen, Pei-Yu] China Med Univ, An Nan Hosp, Canc Ctr, Tainan 709, Taiwan.
   [Tu, Cheng-Hao; Sun, Mao-Feng; Chen, Yi-Hung] China Med Univ, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan.
   [Huang, Yu-Chuen] China Med Univ, China Med Univ Hosp, Sch Chinese Med, Dept Med Res, Taichung 40402, Taiwan.
   [Lee, Yu-Chen; Sun, Mao-Feng] China Med Univ Hosp, Dept Acupuncture, Taichung 404332, Taiwan.
   [Chen, Yi-Hung] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.
   [Chen, Yi-Hung] Asia Univ, Dept Photon & Commun Engn, Taichung 41354, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan;
   Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital;
   China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan; China Medical University
   Taiwan; Asia University Taiwan
RP Chen, YH (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Taichung 40402, Taiwan.; Chen, YH (corresponding author), China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan.; Chen, YH (corresponding author), Asia Univ, Dept Photon & Commun Engn, Taichung 41354, Taiwan.
EM chenchinh2013@gmail.com; jeron888@gmail.com; n71721@mail.tmanh.org.tw;
   n73362@mail.tmanh.org.tw; lordowentu@gmail.com; yuchuen@mail.cmu.edu.tw;
   d5167@mail.cmuh.org.tw; maofeng@mail.cmuh.org.tw;
   yihungchen@mail.cmu.edu.tw
RI ; Tu, Cheng-Hao/GOE-4336-2022; Chen, Yi-Hung/L-8189-2013
OI Huang, Chien-Chen/0000-0003-0250-2170; Tu,
   Cheng-Hao/0000-0002-7695-5570; Chen, Yi-Hung/0000-0002-8946-7939
FU An Nan Hospital, China Medical University in Tainan, Taiwan
   [ANHRF106-02]; China Medical University Hospital, Taichung, Taiwan
   [DMR-109-160, DMR-108-BC-8]; Chinese Medicine Research Center of China
   Medical University under the Featured Areas Research Center Program
FX This study was supported by grants from An Nan Hospital, China Medical
   University in Tainan, Taiwan (ANHRF106-02) and from China Medical
   University Hospital, Taichung, Taiwan (DMR-109-160 and DMR-108-BC-8).
   This work was also partially supported by the Chinese Medicine Research
   Center of China Medical University, under the Featured Areas Research
   Center Program within the framework of the Higher Education Sprout
   Project of the Ministry of Education, Taiwan. The funding sources had no
   involvement in the study design, collection, analysis, and
   interpretation of data, the writing of the report, or the decision to
   submit the article for publication.
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NR 50
TC 24
Z9 28
U1 5
U2 29
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2021
VL 10
IS 16
AR 3694
DI 10.3390/jcm10163694
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UG6GU
UT WOS:000689349100001
PM 34441990
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhong, XL
   Zhang, ZD
   Li, JY
   Liu, DD
   Ma, C
   Wang, GN
AF Zhong, Xuelai
   Zhang, Zhaodi
   Li, Jiaying
   Liu, Dandan
   Ma, Chao
   Wang, Guonian
TI Effects of Electroacupuncture on Gastrointestinal Motility Function,
   Pain, and Inflammation via Transient Receptor Potential Vanilloid
   1 in a Rat Model after Colonic Anastomoses
SO DISEASE MARKERS
LA English
DT Article
ID NF-KAPPA-B; MECHANISM; TRPV1; ACUPUNCTURE; EXPRESSION; ACUPOINT; TARGET
AB Background. Complications after colon surgery are a major obstacle to postoperative recovery. The purpose of this study was to investigate the effect of electroacupuncture (EA) at Zusanli (ST36) on gastrointestinal motility in rats after colonic anastomosis and the mechanism of transient receptor potential vanillin 1 (TRPV1) channel in regulating gastrointestinal motility, pain, and inflammation. Methods. The rats were randomly divided into six groups, including the control, model, EA, sham-EA, capsaicin, and capsaicin+EA groups, with preoperative capsaicin pretreatment and EA treatment at ST36 acupoint after surgery. Rats were treated using EA at ST36 or sham acupoints after surgery for 5 days. Capsaicin was intraperitoneally injected into rats 3 hours before surgery. Gastrointestinal motility was assessed by measuring the gastric residue, small intestinal propulsion in vivo, contractile tension, and frequency of isolated muscle strips in vitro. The mechanical withdrawal threshold (MWT) of abdominal incision skin and spontaneous nociceptive scores were observed and recorded in rats after colon anastomosis. The expressions of TRPV1, substance P (SP), neurokinin 1 (NK1) receptor, nuclear factor kappa-B (NF-kappa B), interleukin- (IL-) 6, L-1 beta, and tumor necrosis factor- (TNF-) alpha were determined. Results. Compared with the model group, electroacupuncture at ST36 point could significantly reduce the residual rate of stomach in rats after operation and increase the propulsive force of the small intestine and the contraction tension of the isolated smooth muscle. Electroacupuncture also increased postoperative day 3 MWT values and decreased postoperative spontaneous nociception scores. In addition, electroacupuncture treatment downregulated the expressions of IL-6, IL-1 beta, TNF-alpha, TRPV1, NF-kappa B, SP, and NK1 receptors in the colon tissue of rats after colonic anastomosis. Conclusions. Our study showed that electroacupuncture at ST36 acupoint could improve gastrointestinal motility in rats after colonic anastomosis and relieve intestinal inflammation and pain. The mechanism may be to inhibit the activation of NF-kappa B and SP/NK1 receptor signaling pathways by inhibiting TRPV1.
C1 [Zhong, Xuelai; Zhang, Zhaodi; Li, Jiaying; Liu, Dandan] Harbin Med Univ, Dept Anesthesiol, Canc Hosp, Harbin 150081, Peoples R China.
   [Ma, Chao] Fourth Hosp Harbin Med Univ, Dept Anesthesiol, Harbin 150081, Peoples R China.
   [Wang, Guonian] Fourth Hosp Harbin Med Univ, Dept Anesthesiol, 150 Haping Rd, Harbin 150081, Peoples R China.
   [Wang, Guonian] Heilongjiang Acad Med Sci, Pain Res Inst, 150 Haping Rd, Harbin 150081, Peoples R China.
C3 Harbin Medical University
RP Wang, GN (corresponding author), Fourth Hosp Harbin Med Univ, Dept Anesthesiol, 150 Haping Rd, Harbin 150081, Peoples R China.; Wang, GN (corresponding author), Heilongjiang Acad Med Sci, Pain Res Inst, 150 Haping Rd, Harbin 150081, Peoples R China.
EM shelley9135@163.com; jody1982@163.com; 1375266310@qq.com;
   714633347@qq.com; machao2019@yeah.net; 600638@hrbmu.edu.cn
RI li, jiaying/LTD-7331-2024; Liu, Dandan/PBW-7538-2025; Wang,
   Guonian/HPH-8253-2023
FU National Natural Science Foundation of China [8177051154, 8170150971]
FX AcknowledgmentsThis study was supported by the National Natural Science
   Foundation of China (grant number 8177051154 and 8170150971).
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NR 42
TC 6
Z9 9
U1 1
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PD JUL 5
PY 2022
VL 2022
AR 5113473
DI 10.1155/2022/5113473
PG 14
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 3F6LB
UT WOS:000830777300001
PM 35845135
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Pérez, C
   Martin-Delgado, J
   Vinuesa, M
   Ibor, PJ
   Guilabert, M
   Gomez, J
   Beato, C
   Sánchez-Jiménez, J
   Velázquez, I
   Calvo-Espinos, C
   Cánovas, ML
   Yáñez, JA
   Rodríguez, M
   Baquero, JL
   Gallach, E
   Folch, E
   Tuca, A
   Santiña, M
   Mira, JJ
AF Perez, Concepcion
   Martin-Delgado, Jimmy
   Vinuesa, Mercedes
   Ibor, Pedro J.
   Guilabert, Mercedes
   Gomez, Jose
   Beato, Carmen
   Sanchez-Jimenez, Juana
   Velazquez, Ignacio
   Calvo-Espinos, Claudio
   Canovas, Maria L.
   Yanez, Jose A.
   Rodriguez, Mireia
   Baquero, Jose L.
   Gallach, Elisa
   Folch, Emma
   Tuca, Albert
   Santina, Manel
   Mira, Jose J.
TI Pain Standards for Accredited Healthcare Organizations (ACDON Project):
   A Mixed Methods Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE pain; cancer; quality of care; accreditation; patient-centered care;
   patient-safety
ID CANCER PAIN; MANAGEMENT; PREVALENCE; PATIENT
AB Up to 50% of cancer patients and up to 90% of those in terminal stages experience pain associated with disease progression, poor quality of life, and social impact on caregivers. This study aimed to establish standards for the accreditation of oncological pain management in healthcare organizations. A mixed methods approach was used. First, a pragmatic literature review was conducted. Second, consensus between professionals and patients was reached using the Nominal Group and Delphi technique in a step that involved anesthesiologists, oncologists, family physicians, nurses, psychologists, patient representatives, and caregivers. Third, eight hospitals participated in a pilot assessment of the level of fulfillment of each standard. A total of 37 standards were extracted. The Nominal Group produced additional standards, of which 60 were included in Questionnaire 0 that was used in the Delphi Technique. Two Delphi voting rounds were performed to reach a high level of consensus, and involved 64 and 62 participants with response rates of 90% and 87%, respectively. Finally, 39 standards for the management of cancer pain were agreed upon. In the self-evaluation, the average range of compliance was between 56.4% and 100%. The consensus standards of the ACDON Project might improve the monitoring of cancer pain management. These standards satisfied the demands of professionals and patients and could be used for the accreditation of approaches in cancer pain management.
C1 [Perez, Concepcion; Vinuesa, Mercedes] La Princesa Univ Hosp, Qual Dept, Pain Unit, Madrid 28006, Spain.
   [Martin-Delgado, Jimmy; Mira, Jose J.] Fdn Promot Hlth & Biomed Res, Atenea Res Grp, Sant Joan dAlacant 03550, Spain.
   [Ibor, Pedro J.] Spanish Soc Primary Care Phys, Pain Res Grp, Valencia 28009, Spain.
   [Guilabert, Mercedes; Mira, Jose J.] Miguel Hernandez Univ, Hlth Psychol Dept, Elche 03202, Spain.
   [Gomez, Jose] Le Fe Hosp, Oncol Dept, Valencia 46026, Spain.
   [Beato, Carmen] Virgen Rocio Univ Hosp, Oncol Dept, Seville 41013, Spain.
   [Sanchez-Jimenez, Juana] Daroca Hlth Ctr, Family Med Dept, Madrid 28017, Spain.
   [Velazquez, Ignacio] Guadix High Resolut Hosp, Pain Unit, Guadix 18500, Spain.
   [Calvo-Espinos, Claudio] Rioja Salud Fdn, Palliat Care Dept, La Rioja 26006, Spain.
   [Canovas, Maria L.; Rodriguez, Mireia] Ourense Hosp Complex, Anesthesiol Dept, Orense 32005, Spain.
   [Yanez, Jose A.] Carlos Haya Hosp, Nursery Dept, Malaga 29010, Spain.
   [Rodriguez, Mireia] Terrassa Hlth Consortium, Nursery Dept, Terrassa 08227, Spain.
   [Baquero, Jose L.] Spanish Forum Patients, Sci Coordinat, Madrid 28018, Spain.
   [Gallach, Elisa] La Fe Hosp, Psychol Dept, Valencia 46026, Spain.
   [Folch, Emma] Francoli Sociosanitary Hosp, Nursery Dept, Tarragona 43005, Spain.
   [Tuca, Albert] Barcelona Clin Hosp, Oncol Dept, Barcelona 08036, Spain.
   [Santina, Manel] Spanish Soc Qual Care, Oviedo 33003, Spain.
   [Mira, Jose J.] Alicante St Joan Hlth Dist, Alicante 03013, Spain.
C3 Universidad Miguel Hernandez de Elche; Virgen del Rocio University
   Hospital; Complexo Hospitalario Universitario de Ourense, Verin e O
   Barco de Valdeorras; Hospital Regional Universitario de Malaga
RP Guilabert, M (corresponding author), Miguel Hernandez Univ, Hlth Psychol Dept, Elche 03202, Spain.
EM concha.phte@gmail.com; jimmy.martind@umh.es; mvinuesa@salud.madrid.org;
   iborvidal@gmail.com; mguilabert@umh.es; jgcodina@outlook.es;
   cbeato@hotmail.com; jsanjin@semg.es; ignavel50@hotmail.com;
   clacales75@yahoo.es; maria.de.la.luz.canovas.martinez@sergas.es;
   jays56@yahoo.es; manel45545@gmail.com; jlbaquero@forodepacientes.org;
   gallach.eli@gmail.com; efolch.gipss@gencat.cat; atuca@clinic.cat;
   msantina@clinic.cat; jose.mira@umh.es
RI ; Mira, José Joaquín/C-8729-2017; TUCA, ALBERT/K-6497-2019; Martin
   Delgado, Jimmy/AAT-1568-2020; Guilabert, Mercedes/U-6135-2019; Santiñà,
   Manel/AAN-8107-2021; Puy, Emma/AAX-5558-2020; Calvo Espinos,
   Claudio/LCD-9654-2024
OI Vinuesa, Mercedes/0000-0003-1786-270X; Mira, José
   Joaquín/0000-0001-6497-083X; TUCA, ALBERT/0000-0002-4633-5856; Martin
   Delgado, Jimmy/0000-0003-4384-9197; Guilabert,
   Mercedes/0000-0002-0706-9911; Calvo Espinos,
   Claudio/0000-0002-5626-2718; Pérez hernández,
   Concepción/0000-0001-5220-8936; , IIS Galicia Sur/0000-0003-3812-7413
FU Ferrer International
FX This work was supported by nonrestrictive funding from Ferrer
   International. No Ferrer International staff participated in the design,
   execution, data capture, interpretation of results, and elaboration of
   the conclusions of this study. The responsibility for the study rested
   entirely with the authors.
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NR 27
TC 3
Z9 3
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2021
VL 11
IS 2
AR 102
DI 10.3390/jpm11020102
PG 11
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA QN8OG
UT WOS:000622710900001
PM 33562456
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, MX
   Baser, RE
   Khanin, R
   Autuori, I
   Li, QS
   Panageas, KS
   Orlow, I
   Mao, JJ
AF Yang, Mingxiao
   Baser, Raymond E.
   Khanin, Raya
   Autuori, Isidora
   Li, Qing S.
   Panageas, Katherine S.
   Orlow, Irene
   Mao, Jun J.
TI COMT Val158Met Affects the Analgesic Response to Acupuncture
   Among Cancer Survivors With Chronic Pain
SO JOURNAL OF PAIN
LA English
DT Article
DE COMT Val158Met; chronic pain; acupuncture; cancer survivors; treatment
   response
ID CATECHOL-O-METHYLTRANSFERASE; MORPHINE; POLYMORPHISM; BIOMARKERS;
   SYMPTOMS; GENETICS; REWARD
AB Catechol-O-methyltransferase (COMT) is the major enzyme involved in the catabolism of dopamine, a neurotransmitter in the brain's reward system. The common COMT polymorphism Val158Met (rs4680 G > A) modulates pain response to opioids through a reward-motivated me-chanism; however, its role in nonpharmacological pain medicine has not been clinically characterized. We genotyped 325 participants from a randomized controlled trial of cancer survivors with chronic musculoskeletal pain. We found that carrying methionine at position 158 (158Met) of COMT, encoded by the A allele, significantly increased the analgesic response to electroacupuncture (74% vs 50%; odds ratio [OR]: 2.79; 95% confidence interval [CI]: 1.31, 6.05; P < .01), but not to auricular acupuncture (68% vs 60%; OR: 1.43; 95% CI: .65, 3.12; P = .37) or usual care (24% vs 18%; OR: 1.46; 95% CI: .38, 7.24; P = .61) compared to Val/Val. These findings raise the possibility that COMT Val158Met might be an important predictor of analgesic response to electroacupuncture, providing novel in-sights into precision nonpharmacologic pain management tailored to individual genetic back-grounds.
C1 [Yang, Mingxiao; Li, Qing S.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,Room 456, New York, NY 10065 USA.
   [Baser, Raymond E.; Autuori, Isidora; Panageas, Katherine S.; Orlow, Irene] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA.
   [Khanin, Raya] Mem Sloan Kettering Canc Ctr, Bioinformat Core Computat Biol Program, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,Room 456, New York, NY 10065 USA.
EM maoj@mskcc.org
RI Yang, Mingxiao/ABF-6416-2021
OI Yang, Mingxiao/0000-0002-6514-3366
FU Department of Defense Office of the Congressionally Directed Medical
   Research Programs through the Peer Reviewed Medical Research Program
   Clinical Trial Award [W81XWH-15-1-0245]; National Institutes of
   Health/National Cancer Institute (NIH/NCI) Cancer Center Support Grant
   [P30 CA008748]; NCI [R01 CA240417]; National Cancer Institute
   [R01CA240417, P30CA008748] Funding Source: NIH RePORTER
FX This work was supported by the Department of Defense Office of the
   Congressionally Directed Medical Research Programs through the Peer
   Reviewed Medical Research Program Clinical Trial Award
   [W81XWH-15-1-0245] and by the National Institutes of Health/National
   Cancer Institute (NIH/NCI) Cancer Center Support Grant P30 CA008748. Dr.
   Mao is supported in part from NCI R01 CA240417.
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NR 61
TC 8
Z9 9
U1 1
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
EI 1528-8447
J9 J PAIN
JI J. Pain
PD SEP
PY 2023
VL 24
IS 9
BP 1721
EP 1730
DI 10.1016/j.jpain.2023.05.005
EA SEP 2023
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA T6LN1
UT WOS:001079082300001
PM 37187218
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Deng, G
AF Deng, Gary
TI Integrative Medicine Therapies for Pain Management in Cancer Patients
SO CANCER JOURNAL
LA English
DT Review
DE Acupuncture; cancer pain; hypnosis; integrative medicine; massage
   therapy; mind-body therapies; mindfulness; music therapy; pain; pain
   management
ID CLINICAL-PRACTICE GUIDELINES; CHRONIC NONCANCER PAIN; BREAST-CANCER;
   MASSAGE THERAPY; REDUCE PAIN; ACUPUNCTURE; METAANALYSIS; SYMPTOMS;
   MUSIC; INTERVENTIONS
AB Pain management for cancer patients should include pharmacologic and nonpharmacologic interventions. Integrative medicine therapies, such as mind-body practice, acupuncture, massage therapy, and music therapy, have been studied for their roles in pain management. Data from randomized controlled trials support the effect of hypnosis, acupuncture, and music therapy in reduction of pain. Mindfulness meditation, yoga, qigong, and massage therapy, although may not reduce pain per se, can relieve anxiety and mood changes, which are commonly associated with pain. In clinical practice, one should also consider burdens and risks to patients, patient preference, and the presence or absence of better alternatives when making decisions on whether an integrative medicine therapy is of clinical value.
C1 [Deng, Gary] Mem Sloan Kettering Canc Ctr, 1429 First Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center
RP Deng, G (corresponding author), Mem Sloan Kettering Canc Ctr, 1429 First Ave, New York, NY 10021 USA.
EM dengg@mskcc.org
FU NIH/NCI Cancer Center Support Grant [P30 CA008748]; National Cancer
   Institute [P30CA008748] Funding Source: NIH RePORTER
FX This research was funded in part through the NIH/NCI Cancer Center
   Support Grant P30 CA008748.
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NR 70
TC 104
Z9 130
U1 1
U2 62
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1528-9117
EI 1540-336X
J9 CANCER J
JI Cancer J.
PD SEP-OCT
PY 2019
VL 25
IS 5
BP 343
EP 348
DI 10.1097/PPO.0000000000000399
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA KB3LR
UT WOS:000506401800008
PM 31567462
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Qi, PF
   Zhou, MY
   Han, WQ
   Li, HX
   Min, L
   Li, JX
   Sun, ZR
   Yin, HN
AF Qi, Pengfei
   Zhou, Mingyuan
   Han, Wenqing
   Li, Hongxiang
   Min, Lu
   Li, Jiaxin
   Sun, Zhongren
   Yin, Hongna
TI Mechanism of the analgesic effect of electroacupuncture on bone cancer
   pain through the neuro-immune system: progress based on animal
   experiments
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE electroacupuncture; bone cancer pain; morphine tolerance; mechanism;
   neuroscience; immunity; animal model
ID OPIOID RECEPTOR DESENSITIZATION; GENE-RELATED PEPTIDE; RAT MODEL;
   ASTROCYTE ACTIVATION; MORPHINE-TOLERANCE; PROSTATE-CANCER; P2X3
   RECEPTORS; SPINAL-CORD; ENDOTHELIN; INHIBITION
AB This article summarizes the mechanism of the analgesic effect of electroacupuncture (EA) on BCP by analyzing the progress of animal experimental research on the treatment of bone cancer pain (BCP). As a kind of chronic specific pain that both overlaps and incompletely coincides with inflammatory pain and neuropathic pain, BCP is mostly clinically treated with opioids such as morphine as the first-line analgesic for BCP, but the long-term application is prone to a series of unavoidable side-effects, such as tolerance, dependence, as well as cognitive impairment, nausea, constipation, and nephrotoxicity. Therefore, there is an urgent need to seek safer and more effective treatment measures. As a safe, reliable and consistently efficacious analgesic, EA produces analgesic effects in inflammatory pain, neuropathic pain and BCP. EA not only attenuates the nociceptive sensitization of BCP by modulating the release of nociception-related neurotransmitters and receptors in the nervous system, but also exerts analgesic effects on BCP by modulating the expression of inflammatory factors in the immune system, inhibiting glial cell activation, and T cell proliferation. At present, EA research on the analgesic mechanism of BCP has made some progress, but there are still problems that need to be solved, such as the lack of standardization of acupoints and parameters, weak clinical validation, a single research model, and limitations in the perspective of analgesic mechanism research. It is suggested that future studies should be based on databases such as AcuEBase v1.0 to develop standardized EA acupoint combinations and frequency parameters to provide a scientific basis for EA standardization. At the same time, the sample size should be expanded and the experimental design should be improved in order to promote the transformation of animal experiments into clinical applications. In addition, it should be expanded to more types of cancer bone metastasis pain models to verify the consistency of the analgesic effect of EA in different BCP models. Future studies could also explore the multi-target synergistic analgesic effects of EA from a microbial-immune axis perspective with the help of tools such as MicrobeTCM. And optimize the treatment plan of BCP through EA combined with drug therapy. It is believed that with the progress of science and technology as well as the continuous exploration of human beings, the complex mechanism of BCP will be overcome by human beings eventually.
C1 [Qi, Pengfei; Zhou, Mingyuan; Han, Wenqing; Li, Hongxiang; Min, Lu; Li, Jiaxin; Sun, Zhongren; Yin, Hongna] Heilongjiang Univ Chinese Med, Haerbin, Peoples R China.
   [Yin, Hongna] Heilongjiang Univ Tradit Chinese Med, Hosp 2, Harbin, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine
RP Yin, HN (corresponding author), Heilongjiang Univ Chinese Med, Haerbin, Peoples R China.; Yin, HN (corresponding author), Heilongjiang Univ Tradit Chinese Med, Hosp 2, Harbin, Peoples R China.
EM hljzyydxfsey@163.com
RI HAN, Wenqing/LMO-4945-2024; qi, pengfei/LBI-4376-2024; Yin,
   Hongna/PEX-7570-2025
FU Heilongjiang Provincial Natural Science Foundation of China [LH2024H231]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   Heilongjiang Provincial Natural Science Foundation of China LH2024H231.
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NR 104
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD DEC 10
PY 2025
VL 16
AR 1693978
DI 10.3389/fneur.2025.1693978
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AD0ZQ
UT WOS:001645272200001
PM 41451423
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huang, XM
   Cai, HX
   Zeng, W
   Zeng, XQ
   Xiao, XH
   Liu, Y
   Xu, YH
   Liu, XM
   Zhong, QH
AF Huang, Xiaomei
   Cai, Hanxue
   Zeng, Wen
   Zeng, Xueqin
   Xiao, Xinhong
   Liu, Yi
   Xu, Yanhong
   Liu, Xiaomei
   Zhong, Qinghua
TI Effect of auricular point acupressure combined with three-step analgesic
   therapy on cancer pain
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE cancer pain; pain relief; auricular point pressing; three-step analgesic
   therapy
AB Introduction/Objective The objective was to evaluate the effect of auricular point pressing with beans combined with three-step analgesic therapy on cancer pain. Methods Sixty patients with cancer admitted to the Ganzhou Cancer Hospital from January to December 2021 were selected and randomly divided into experimental and control groups. The control group received three-step pain relief and routine care, while the experimental group was treated with auricular point acupressure combined with three-step analgesic therapy. The pain intensity was assessed by a numerical rating scale (NRS) at 0, 24, 48, and 72 h after treatment, and the incidence of adverse reactions was recorded. Results The NRS score of the experimental group was lower than that of the control group (Ftreatment = 105.521, p = 0.001). The difference in NRS scores before and 24, 48, and 72 h after treatment was statistically significant (Ftime = 335.521, p = 0.001). The number of eruption pain cases in the experimental group and the control group was found to be statistically significant (chi 2= 10.767, p = 0.001), and the occurrence of eruption pain in the control group was more severe than that in the experimental group (Z = -4.472, p = 0.001). The incidence of adverse reactions in the experimental and control groups was 3.33% and 30%, respectively, and the difference was statistically significant (chi 2= 12.738, p = 0.001). Conclusion The combination of auricular point pressing and three-step ladder analgesic therapy can significantly improve the pain of cancer patients.
C1 [Huang, Xiaomei; Cai, Hanxue; Zeng, Xueqin; Xiao, Xinhong; Liu, Yi; Xu, Yanhong] Ganzhou Canc Hosp, Dept Nursing, Ganzhou, Peoples R China.
   [Zeng, Wen; Liu, Xiaomei; Zhong, Qinghua] Ganzhou Canc Hosp, Dept Head & Neck Surg, 19 Huayuan Qian Rd, Ganzhou 341000, Peoples R China.
RP Zhong, QH (corresponding author), Ganzhou Canc Hosp, Dept Head & Neck Surg, 19 Huayuan Qian Rd, Ganzhou 341000, Peoples R China.
EM ping2023liu@163.com
FU Jiangxi Provincial Administration of Traditional Chinese Medicine
   [2020A0249]
FX This work was supported by the Jiangxi Provincial Administration of
   Traditional Chinese Medicine (2020A0249) .
CR [Anonymous], 2018, WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents
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NR 30
TC 0
Z9 0
U1 3
U2 3
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD MAR-APR
PY 2025
VL 153
IS 3-4
BP 187
EP 192
DI 10.2298/SARH240919022H
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4SJ4F
UT WOS:001525533500005
OA gold
DA 2026-01-16
ER

PT J
AU Lee, B
   Kwon, CY
   Lee, HW
   Nielsen, A
   Wieland, LS
   Kim, TH
   Birch, S
   Alraek, T
   Lee, MS
AF Lee, Boram
   Kwon, Chan-Young
   Lee, Hye Won
   Nielsen, Arya
   Wieland, L. Susan
   Kim, Tae-Hun
   Birch, Stephen
   Alraek, Terje
   Lee, Myeong Soo
TI Different Outcomes According to Needling Point Location Used in Sham
   Acupuncture for Cancer-Related Pain: A Systematic Review and Network
   Meta-Analysis
SO CANCERS
LA English
DT Review
DE acupuncture therapy; cancer pain; cancer-related pain; placebo; sham
   acupuncture
ID AURICULAR ACUPUNCTURE; CONTROLLED-TRIAL; BREAST-CANCER; INTERVENTIONS;
   MANAGEMENT; SYMPTOMS; SOCIETY; WOMEN; REAL; CARE
AB Simple Summary When sham acupuncture was set as a control in previous acupuncture clinical trials, the sham procedure was conducted either at the same points that were used for the verum acupuncture group or at nonindicated points. The network meta-analysis according to needling point location used in sham acupuncture for cancer-related pain revealed no significant difference in pain severity between verum acupuncture and sham acupuncture using the same points as verum acupuncture. However, verum acupuncture significantly improved the pain severity compared to sham acupuncture at sham points. Sham acupuncture needling at the same points as verum acupuncture is not a true placebo due to the lack of consideration for acupuncture point specificity.Abstract Numerous acupuncture studies have been conducted on cancer-related pain; however, its efficacy compared to sham acupuncture remains controversial. We confirmed whether the outcome of acupuncture differs according to the needling points of sham acupuncture for cancer-related pain. We searched 10 databases on 23 May 2023 to screen acupuncture trials using sham acupuncture or waiting list as controls for cancer-related pain. Sham acupuncture was classified into two types, depending on whether the needling was applied at the same locations as verum acupuncture (SATV) or not (SATS). A network meta-analysis (NMA) was performed on the basis of a frequentist approach to assess pain severity. Eight studies (n = 574 participants) were included in the review, seven of which (n = 527 participants) were included in the NMA. The pain severity was not significantly different between SATV and verum acupuncture, but verum acupuncture significantly improved pain severity compared to SATS. The risk of bias affecting the comparisons between the verum and sham acupuncture was generally low. Previous acupuncture trials for cancer-related pain showed differing outcomes of sham and verum acupuncture, depending on the needling points of sham acupuncture. The application of SATV cannot be considered a true placebo, which leads to an underestimation of the efficacy of verum acupuncture.
C1 [Lee, Boram; Lee, Myeong Soo] Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
   [Kwon, Chan-Young] Dong Eui Univ, Coll Korean Med, Dept Oriental Neuropsychiat, Pusan 47227, South Korea.
   [Lee, Hye Won] Korea Inst Oriental Med, KM Convergence Res Div, Daejeon 305811, South Korea.
   [Nielsen, Arya] Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA.
   [Wieland, L. Susan] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA.
   [Kim, Tae-Hun] Kyung Hee Univ, Korean Med Hosp, Korean Med Clin Trial Ctr, Seoul 02447, South Korea.
   [Birch, Stephen; Alraek, Terje] Kristiania Univ Coll, Sch Hlth Sci, N-0317 Oslo, Norway.
   [Alraek, Terje] Natl Res Ctr Complementary & Alternat Med NAFKAM, Inst Hlth Sci, Fac Hlth Sci, Dept Community Med, N-9037 Tromso, Norway.
C3 Korea Institute of Oriental Medicine (KIOM); Dong-Eui University; Korea
   Institute of Oriental Medicine (KIOM); Icahn School of Medicine at Mount
   Sinai; University System of Maryland; University of Maryland Baltimore;
   Kyung Hee University; Kristiania University College
RP Lee, MS (corresponding author), Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
EM qhfka9357@kiom.re.kr; beanalogue@naver.com; hwlee@kiom.re.kr;
   arya@guasha.com; lswieland@gmail.com; rockandmineral@gmail.com;
   sjbirch@gmail.com; terje.alrak@uit.no; drmslee@gmail.com
RI ; Nielsen, Arya/GXI-0466-2022; Kim, Tae-Hun/G-8728-2014; Kwon,
   Chan-Young/ABI-2048-2022; Lee, Hye/D-9081-2016; Wieland, Lisa
   Susan/AFL-4071-2022; Alræk, Terje/AAG-7001-2021; Lee, Myeong
   Soo/C-8147-2013
OI Lee, Boram/0000-0003-1679-0644; Birch, Stephen/0000-0001-7986-6568;
   Nielsen, Arya/0000-0003-3370-9123; Kim, Tae-Hun/0000-0002-8448-3219;
   Kwon, Chan-Young/0000-0003-0068-9904; Lee, Myeong
   Soo/0000-0001-6651-7641
FU Korea Institute of Oriental Medicine
FX No Statement Available
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NR 54
TC 10
Z9 12
U1 9
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD DEC
PY 2023
VL 15
IS 24
AR 5875
DI 10.3390/cancers15245875
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DH8R1
UT WOS:001131236100001
PM 38136419
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Walters, SJ
AF Walters, Stephen John
TI MASSAGE AND CANCER: PRACTICE GUIDELINES
SO JOURNAL OF THE AUSTRALIAN TRADITIONAL-MEDICINE SOCIETY
LA English
DT Article
DE Massage; Cancer; Guidelines; Evidence-based medicine; Complementary
   medicine
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER; COMPLEMENTARY THERAPIES;
   LUNG-CANCER; CHEMOTHERAPY; ACUPRESSURE; ANXIETY; NAUSEA; WOMEN; PAIN
AB Massage is a commonly sought therapy by patients with cancer. Recent research indicates that massage is a valid application for cancer pain, anxiety, nausea and vomitting, lymphedema, and carer support. However, complications such as coagulation disorders, metastatsis to bone, open wounds, and dermatitis require medical management. The evidence supports that massage therapists can offer treatment for patients with cancer with confidence.
RP Walters, SJ (corresponding author), 678 Port Rd, Beverley, SA 5009, Australia.
EM camroc@iinet.net.au
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NR 31
TC 6
Z9 7
U1 2
U2 13
PU AUSTRALIAN TRADITIONAL-MEDICINE SOC LTD
PI MEADOWBANK
PA UNIT 12, 27 BANK ST, PO BOX 1027, MEADOWBANK, NSW 2114, AUSTRALIA
SN 1326-3390
J9 J AUST TRADIT-MED SO
JI J. Aust. Tradit.-Med. Soc.
PD SEP
PY 2010
VL 16
IS 3
BP 141
EP 143
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 673XH
UT WOS:000283697000002
DA 2026-01-16
ER

PT J
AU Hochberg, U
   Berger, A
   Atias, M
   Tellem, R
   Strauss, I
AF Hochberg, Uri
   Berger, Asaf
   Atias, Miri
   Tellem, Rotem
   Strauss, Ido
TI Tailoring of neurosurgical ablative procedures in the management of
   refractory cancer pain
SO REGIONAL ANESTHESIA AND PAIN MEDICINE
LA English
DT Article
ID CORDOTOMY; CINGULOTOMY
AB Introduction Neurosurgical ablative procedures can offer immediate and effective pain relief for patients suffering from refractory cancer pain. However, choosing the appropriate procedure for each patient may not be straightforward and warrants an interdisciplinary approach. The purpose of the current study was to evaluate the outcome of patients with cancer who were carefully selected for neurosurgical intervention by a dedicated interdisciplinary team composed of a palliative physician and nurse practitioner, a pain specialist and a neurosurgeon.
   Methods A retrospective review was carried out on all patients who underwent neurosurgical ablative procedures in our institute between March 2015 and September 2019. All patients had advanced metastatic cancer with unfavorable prognosis and suffered from intractable oncological pain. Each treatment plan was devised to address the patients' specific pain syndromes.
   Results A total of 204 patients were examined by our service during the study period. Sixty-four patients with localized pain and nineteen patients with diffuse pain syndromes were selected for neurosurgical interventions, either targeted disconnection of the spinothalamic tract or stereotactic cingulotomy. Substantial pain relief was reported by both groups immediately (cordotomy: Numerical Rating Scale (NRS) 9 >= 1, p=0.001, cingulotomy: NRS 9 >= 2, p=0.001) and maintained along the next 3-month follow-up visits.
   Conclusions An interdisciplinary collaboration designated to provide neurosurgical ablative procedures among carefully selected patients could culminate in substantial relief of intractable cancer pain.
C1 [Hochberg, Uri] Tel Aviv Sourasky Med Ctr, Inst Pain Med, Div Anesthesiol, Tel Aviv, Israel.
   [Hochberg, Uri; Berger, Asaf; Tellem, Rotem; Strauss, Ido] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Berger, Asaf; Atias, Miri] Tel Aviv Sourasky Med Ctr, Dept Neurosurg, Tel Aviv, Israel.
   [Tellem, Rotem] Tel Aviv Sourasky Med Ctr, Palliat Care Serv, Tel Aviv, Israel.
   [Strauss, Ido] Tel Aviv Sourasky Med Ctr, Dept Neurosurg, Neuromodulat Unit, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center
RP Hochberg, U (corresponding author), Tel Aviv Sourasky Med Ctr, Inst Pain Med, Div Anesthesiol, Tel Aviv, Israel.
EM urihochberg@hotmail.com
OI Strauss, Ido/0000-0002-1988-9685; Berger, Assaf/0000-0003-1198-2807
CR Afsharimani B, 2015, SUPPORT CARE CANCER, V23, P1473, DOI 10.1007/s00520-015-2678-9
   [Anonymous], 1986, CANC PAIN REL
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NR 19
TC 6
Z9 7
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1098-7339
EI 1532-8651
J9 REGION ANESTH PAIN M
JI Region. Anesth. Pain Med.
PD SEP
PY 2020
VL 45
IS 9
BP 696
EP 701
DI 10.1136/rapm-2020-101566
PG 6
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA NK9DO
UT WOS:000567029500007
PM 32699105
DA 2026-01-16
ER

PT J
AU Zhang, X
   Yang, WJ
   Shang, JL
   Dan, WC
   Shi, L
   Tong, L
   Yang, GW
AF Zhang, Xu
   Yang, Wenjing
   Shang, Junliang
   Dan, Wenchao
   Shi, Lin
   Tong, Li
   Yang, Guowang
TI The lower He-sea points playing a significant role in postoperative
   ileus in colorectal cancer treated with acupuncture: based on
   machine-learning
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE acupuncture; postoperative ileus; colorectal cancer; machine-learning;
   association rules
ID ZUSANLI ST 36; LAPAROSCOPIC SURGERY; ELECTROACUPUNCTURE; STIMULATION;
   RECOVERY; MOTILITY; ACUPOINT
AB BackgroundPostoperative ileus (POI) is a common complication following abdominal surgery, which can lead to significant negative impacts on patients' well-being and healthcare costs. However, the efficacy of current treatments is not satisfactory. The purpose of this study was to evaluate the therapeutic effects of acupuncture intervention and explore the regulation of acupoint selection for treating POI in colorectal cancer (CRC) patients. MethodsWe searched eight electronic databases to identify randomized controlled trials (RCTs) on acupuncture for POI in CRC and conducted a meta-analysis. Subsequently, we utilized the Apriori algorithm and the Frequent pattern growth algorithm, in conjunction with complex network and cluster analysis, to identify association rules of acupoints. ResultsThe meta-analysis showed that acupuncture led to significant reductions in time to first defecation (MD=-20.93, 95%CI: -25.35, -16.51; I-2 = 93.0%; p < 0.01; n=2805), first flatus (MD=-15.08, 95%CI: -18.39, -11.76; I-2 = 96%; p < 0.01; n=3284), and bowel sounds recovery (MD=-10.96, 95%CI: -14.20, -7.72; I-2 = 94%; p < 0.01; n=2043). A subgroup analysis revealed that acupuncture not only reduced the duration of POI when administered alongside conventional care but also further expedited the recovery of gut function after colorectal surgery when integrated into the enhanced recovery after surgery (ERAS) pathway. The studies included in the analysis reported no instances of serious adverse events associated with acupuncture. We identified Zusanli (ST36), Shangjuxu (ST37), Neiguan (PC6), Sanyinjiao (SP6), Xiajuxu (ST39), Hegu (LI4), Tianshu (ST25), and Zhongwan (RN12) as primary acupoints for treating POI. Association rule mining suggested potential acupoint combinations including {ST37, ST39}& GE;{ST36}, {PC6, ST37}& GE;{ST36}, {SP6, ST37}& GE;{ST36}, and {ST25, ST37}& GE;{ST36}. ConclusionMeta-analysis indicates acupuncture's safety and superior effectiveness over postoperative care alone in facilitating gastrointestinal recovery. Machine-learning approaches highlight the importance of the lower He-sea points, including Zusanli (ST36) and Shangjuxu (ST37), in treating POI in CRC patients. Incorporating additional acupoints such as Neiguan (PC6) (for pain and vomiting) and Sanyinjiao (SP6) (for abdominal distension and poor appetite) can optimize treatment outcomes. These findings offer valuable insights for refining treatment protocols in both clinical and experimental settings, ultimately enhancing patient care.
C1 [Zhang, Xu; Tong, Li] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Nutr, Beijing, Peoples R China.
   [Yang, Wenjing; Shi, Lin; Yang, Guowang] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing, Peoples R China.
   [Shang, Junliang] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Surg, Beijing, Peoples R China.
   [Dan, Wenchao] Capital Med Univ, Sch Grad, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University
RP Yang, GW (corresponding author), Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, Beijing, Peoples R China.
EM guowang_yang@163.com
RI Dan, WenChao/HPC-0733-2023
OI Dan, WenChao/0000-0002-0188-8262
FU National Natural Science Foundation of China [82174453]; Hospital-level
   Project and Cooperation Project of Beijing Hospital of Traditional
   Chinese Medicine, Capital Medical University [LYYB202217]; Innovative
   Work Studio Project for Employees of Beijing Hospital of Traditional
   Chinese Medicine, Capital Medical University [ZT202108]
FX This study was supported by National Natural Science Foundation of China
   (No.82174453); Hospital-level Project and Cooperation Project of Beijing
   Hospital of Traditional Chinese Medicine, Capital Medical University
   (No.LYYB202217); Innovative Work Studio Project for Employees of Beijing
   Hospital of Traditional Chinese Medicine, Capital Medical University
   (No.ZT202108).
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NR 78
TC 11
Z9 13
U1 4
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUL 24
PY 2023
VL 13
AR 1206196
DI 10.3389/fonc.2023.1206196
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O4GW2
UT WOS:001043425600001
PM 37564931
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Sima, L
   Fan, BF
   Yan, LT
   Shui, Y
AF Sima, Lei
   Fan, Bifa
   Yan, Longtao
   Shui, Yuan
TI Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with
   Morphine Tolerance
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID GENE-RELATED PEPTIDE; NEUROPATHIC PAIN
AB Objective. To explore the efficacy of electroacupuncture treatment in cancer induced bone pain (CIBP) rat model with morphine tolerance and explore changes of calcitonin-gene related peptide (CGRP) expression in dorsal root ganglion (DRG). Methods. Forty SD rats were divided into five groups: sham, CIBP (B), CIBP + morphine (BM), CIBP + electroacupuncture (BE), and CIBP + morphine + electroacupuncture (BME). B, BM, BE, and BME groups were prepared CIBP model. The latter three groups then accepted morphine, electroacupuncture, and morphine combined electroacupuncture, separately, nine days consecutively (M1 to M9). Mechanical withdraw threshold(MWT) was evaluated. Results. BE group only had differences in M1, M2, and M3 compared to B group (P < 0.01). From M5, BM group showed significantly decreased MWT. Electroacupuncture could obtain analgesic effects only at early stage (M1 to M5). From M5 to M9, BME had the differences with BM group (P < 0.01). IOD value of CGRP in BM and BME was substantially less than in B group. CGRP in BME was significantly lower than that in BM group (P < 0.01). Conclusion. When used in combination with electroacupuncture, morphine could result in improving analgesic effects and reducing tolerance. CGRP may be associated with pain behaviors.
C1 [Sima, Lei; Fan, Bifa; Yan, Longtao; Shui, Yuan] China Japan Friendship Hosp, Natl Pain Management & Res Ctr, Beijing, Peoples R China.
C3 China-Japan Friendship Hospital
RP Sima, L (corresponding author), China Japan Friendship Hosp, Natl Pain Management & Res Ctr, Beijing, Peoples R China.
EM simalei75@126.com
FU National Natural Science Foundation of China [81403253]
FX This survey was supported by National Natural Science Foundation of
   China (no. 81403253).
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NR 17
TC 6
Z9 7
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 8028474
DI 10.1155/2016/8028474
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DW2LS
UT WOS:000383474500001
PM 27672401
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Spiegel, MA
   Chen, GH
   Solla, AC
   Hingula, LP
   Legler, A
   Gulati, A
AF Spiegel, Matthew A.
   Chen, Grant H.
   Solla, Antonio C.
   Hingula, Lee P.
   Legler, Aron
   Gulati, Amitabh
TI Evaluation of an Intrathecal Drug Delivery Protocol Leads to Rapid
   Reduction of Systemic Opioids in the Oncological Population
SO JOURNAL OF PALLIATIVE MEDICINE
LA English
DT Article
DE bupivacaine; intrathecal drug delivery systems; morphine equivalents;
   oncological pain
ID CANCER PAIN; NONMALIGNANT PAIN; DOUBLE-BLIND; ANALGESIA;
   RECOMMENDATIONS; BUPIVACAINE; MANAGEMENT; EFFICACY; INFUSION; SAFETY
AB Objective:The article that follows is purposed at demonstrating how IT opioid plus bupivacaine achieves sustained acceptable pain relief while simultaneously rapidly reducing oral morphine equivalents (OME). Background:Cancer patients represent a population with significant morbidity, pain, and limited life expectancy. It is, therefore, vital to achieve satisfactory analgesia quickly and safely. To date, there is limited data in the literature that discusses efficacy of combined intrathecal (IT) medication therapy in reducing systemic opioids in the oncological population. Methods:This was a retrospective analysis that reviewed cancer pain patients from day of IT pump implantation through the six-month postoperative time point. A cohort of 50 oncological patients who had intrathecal drug delivery systems (IDDSs) implanted at Memorial Sloan Kettering Cancer Center between 2017 and 2019 were studied. Median OMEs were the primary modality of analysis for this review. Mean visual analogue scale scores were secondarily reviewed. Results:Median OMEs decreased from 503 preoperative to 105 at six months postoperative time point. Median time to discharge was 6.5 days. Unfortunately, due to malignant mortality, 27 patients did not make it to the 6-month postoperative time point. Discussion:IDDSs with opioid plus bupivacaine represent a safe and efficient route toward expeditious pain relief and decreased OMEs in the cancer pain population.
C1 [Spiegel, Matthew A.; Solla, Antonio C.] NewYork Presbyterian Weill Cornell Med, Dept Anesthesiol, New York, NY USA.
   [Chen, Grant H.; Hingula, Lee P.; Legler, Aron; Gulati, Amitabh] Mem Sloan Kettering Canc Ctr, Dept Anesthesiol & Crit Care Med, New York, NY 10021 USA.
C3 Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering
   Cancer Center
RP Chen, GH (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Anesthesiol & Crit Care, 1275 York Ave, New York, NY 10065 USA.
EM cheng@mskcc.org
OI Chen, Grant H/0000-0003-2819-4751
FU Memorial Sloan Kettering Cancer Center Support Grant (P30 core grant);
   Department of Anesthesiology and Critical Care; National Cancer
   Institute [P30CA008748] Funding Source: NIH RePORTER
FX This study was supported by Memorial Sloan Kettering Cancer Center
   Support Grant (P30 core grant) and the Department of Anesthesiology and
   Critical Care.
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NR 28
TC 9
Z9 9
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-6218
EI 1557-7740
J9 J PALLIAT MED
JI J. Palliat. Med.
PD MAR 1
PY 2021
VL 24
IS 3
BP 418
EP 422
DI 10.1089/jpm.2020.0206
EA JUL 2020
PG 5
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA QP9GS
UT WOS:000547877100001
PM 32640912
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Mao, JJ
   Ismaila, N
   Bao, T
   Barton, D
   Ben-Arye, E
   Garland, EL
   Greenlee, H
   Leblanc, T
   Lee, RT
   Lopez, AM
   Loprinzi, C
   Lyman, GH
   MacLeod, J
   Master, VA
   Ramchandran, K
   Wagner, LI
   Walker, EM
   Bruner, DW
   Witt, CM
   Bruera, E
AF Mao, Jun J.
   Ismaila, Nofisat
   Bao, Ting
   Barton, Debra
   Ben-Arye, Eran
   Garland, Eric L.
   Greenlee, Heather
   Leblanc, Thomas
   Lee, Richard T.
   Lopez, Ana Maria
   Loprinzi, Charles
   Lyman, Gary H.
   MacLeod, Jodi
   Master, Viraj A.
   Ramchandran, Kavitha
   Wagner, Lynne I.
   Walker, Eleanor M.
   Bruner, Deborah Watkins
   Witt, Claudia M.
   Bruera, Eduardo
TI Integrative Medicine for Pain Management in Oncology: Society for
   Integrative Oncology-ASCO Guideline
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID INDUCED ORAL MUCOSITIS; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL
   NEUROPATHY; RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER PATIENTS;
   QUALITY-OF-LIFE; INHIBITOR-INDUCED ARTHRALGIA; BRIEF HYPNOSIS
   INTERVENTION; STEM-CELL TRANSPLANTATION; CONTROLLED CLINICAL-TRIAL
AB PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer.METHODS The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included pain intensity, symptom relief, and adverse events. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations.RESULTS The literature search identified 227 relevant studies to inform the evidence base for this guideline.RECOMMENDATIONS Among adult patients, acupuncture should be recommended for aromatase inhibitor-related joint pain. Acupuncture or reflexology or acupressure may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may be recommended to patients who experience procedural pain. Massage may be recommended to patients experiencing pain during palliative or hospice care. These recommendations are based on an intermediate level of evidence, benefit outweighing risk, and with moderate strength of recommendation. The quality of evidence for other mind-body interventions or natural products for pain is either low or inconclusive. There is insufficient or inconclusive evidence to make recommendations for pediatric patients. More research is needed to better characterize the role of integrative medicine interventions in the care of patients with cancer.
C1 [Mao, Jun J.; Bao, Ting] Mem Sloan Kettering Canc Ctr, New York, NY USA.
   [Ismaila, Nofisat] Amer Soc Clin Oncol, Alexandria, VA USA.
   [Barton, Debra] Univ Michigan, Sch Nursing, Ann Arbor, MI USA.
   [Ben-Arye, Eran] Clalit Hlth Serv, Lin Med Ctr, Haifa, Israel.
   [Ben-Arye, Eran] Clalit Hlth Serv, Carmel Med Ctr, Haifa, Israel.
   [Ben-Arye, Eran] Technion Fac Med, Haifa, Israel.
   [Garland, Eric L.] Univ Utah, Coll Social Work, Salt Lake City, UT USA.
   [Greenlee, Heather; Lyman, Gary H.] Fred Hutchinson Canc Res Ctr, Seattle, WA USA.
   [Leblanc, Thomas] Duke Univ, Sch Med, Durham, NC USA.
   [Lee, Richard T.] City Hope Comprehens Canc Ctr, Duarte, CA USA.
   [Lopez, Ana Maria] Thomas Jefferson Sidney Kimmel Canc Ctr, Philadelphia, PA USA.
   [Loprinzi, Charles] Mayo Clin, Rochester, MN USA.
   [MacLeod, Jodi] Mem Sloan Kettering Integrat Med Serv, New York, NY USA.
   [Master, Viraj A.; Bruner, Deborah Watkins] Emory Univ, Winship Canc Inst, Atlanta, GA USA.
   [Ramchandran, Kavitha] Stanford Univ, Palo Alto, CA USA.
   [Wagner, Lynne I.] Wake Forest Sch Med, Winston Salem, NC USA.
   [Walker, Eleanor M.] Henry Ford Hosp, Detroit, MI USA.
   [Witt, Claudia M.] Univ Hosp Zurich, Zurich, Switzerland.
   [Bruera, Eduardo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 Memorial Sloan Kettering Cancer Center; American Society of Clinical
   Oncology; University of Michigan System; University of Michigan; Clalit
   Health Services; Clalit Health Services; Carmel Medical Center; Technion
   Israel Institute of Technology; Rappaport Faculty of Medicine; Utah
   System of Higher Education; University of Utah; Fred Hutchinson Cancer
   Center; Duke University; City of Hope; Mayo Clinic; Emory University;
   Stanford University; Wake Forest University; Henry Ford Health System;
   Henry Ford Hospital; University of Zurich; University Zurich Hospital;
   University of Texas System; UTMD Anderson Cancer Center
RP Mao, JJ (corresponding author), Soc Integrat Oncol, 4301 50th St NW,Suite 300 PMB 1032, Washington, DC 20016 USA.
EM guidelines@integrativeonc.org
RI Ismaila, Nofisat/HGC-3899-2022; Lyman, Gary/K-5227-2019; LeBlanc,
   Thomas/AAT-3650-2020; Lopez, Ana Maria/KII-1580-2024; Witt med, Claudia
   M/AAX-2370-2021; Lee, Richard/AAS-1416-2021
OI Bao, Ting/0000-0003-4437-2597; Mao, Jun/0000-0001-9229-0380; LeBlanc,
   Thomas/0000-0002-0546-7895; Ramchanan, Kavitha/0000-0002-9033-819X;
   Lopez, Ana Maria/0000-0002-2759-5353; Witt med, Claudia
   M/0000-0002-5440-7805; Lee, Richard/0000-0001-9916-6155
FU Samueli Foundation
FX Supported by a generous grant from the Samueli Foundation to the Society
   for Integrative Oncology to develop clinical practice guidelines
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NR 276
TC 194
Z9 226
U1 13
U2 113
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD DEC 1
PY 2022
VL 40
IS 34
BP 3998
EP +
DI 10.1200/JCO.22.01357
PG 30
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 6R3KD
UT WOS:000892205500012
PM 36122322
OA Bronze
DA 2026-01-16
ER

PT J
AU Berger, A
   Hochberg, U
   Zegerman, A
   Tellem, R
   Strauss, I
AF Berger, Assaf
   Hochberg, Uri
   Zegerman, Alexander
   Tellem, Rotem
   Strauss, Ido
TI Neurosurgical ablative procedures for intractable cancer pain
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE ablative procedures; cordotomy; cingulotomy; mesencephalotomy;
   intractable; refractory cancer pain; oncology
ID PUNCTATE MIDLINE MYELOTOMY; STEREOTACTIC MESENCEPHALOTOMY; PERCUTANEOUS
   CORDOTOMY; MANAGEMENT; RELIEF; CINGULOTOMY; PREVALENCE; PLEA
AB OBJECTIVE Cancer patients suffering from severe refractory pain may benefit from targeted ablative neurosurgical procedures aimed to disconnect pain pathways in the spinal cord or the brain. These patients often present with a plethora of medical problems requiring careful consideration before surgical interventions. The authors present their experience at an interdisciplinary clinic aimed to facilitate appropriate patient selection for neurosurgical procedures, and the outcome of these interventions.
   METHODS This study was a retrospective review of all patients who underwent neurosurgical interventions for cancer pain in the authors' hospital between March 2015 and April 2018. All patients had advanced metastatic cancer with limited life expectancy and suffered from intractable oncological pain.
   RESULTS Sixty patients underwent surgery during the study period. Forty-three patients with localized pain underwent disconnection of the spinal pain pathways: 34 percutaneous-cervical and 5 open-thoracic cordotomies, 2 stereotactic mesencephalotomies, and 2 midline myelotomies. Thirty-nine of 42 patients (93%) who completed these procedures had excellent immediate postoperative pain relief. At 1 month the improvement was maintained in 30/36 patients (83%) available for follow-up. There was 1 case of hemiparesis. Twenty patients with diffuse pain underwent stereotactic cingulotomy. Nineteen of these patients reported substantial pain relief immediately after the operation. At 1 month good pain relief was maintained in 13/17 patients (76%) available for follow-up, and good pain relief was also found at 3 months in 7/11 patients (64%). There was no major morbidity or mortality.
   CONCLUSIONS With careful patient selection and tailoring of the appropriate procedure to the patient's pain syndrome, the authors' experience indicates that neurosurgical procedures are safe and effective in alleviating suffering in patients with intractable cancer pain.
C1 [Berger, Assaf; Strauss, Ido] Tel Aviv Med Ctr & Sch Med, Dept Neurosurg, Tel Aviv, Israel.
   [Strauss, Ido] Tel Aviv Med Ctr & Sch Med, Neuromodulat Unit, Tel Aviv, Israel.
   [Tellem, Rotem] Tel Aviv Med Ctr & Sch Med, Palliat Care Serv, Tel Aviv, Israel.
   [Hochberg, Uri] Tel Aviv Med Ctr & Sch Med, Inst Pain Med, Tel Aviv, Israel.
   [Zegerman, Alexander] Tel Aviv Med Ctr & Sch Med, Div Anesthesiol, Tel Aviv, Israel.
   [Berger, Assaf; Hochberg, Uri; Zegerman, Alexander; Tellem, Rotem; Strauss, Ido] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv University; Sackler
   Faculty of Medicine
RP Strauss, I (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
EM idos@tlvmc.gov.il
OI Strauss, Ido/0000-0002-1988-9685; Berger, Assaf/0000-0003-1198-2807
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NR 41
TC 17
Z9 17
U1 0
U2 2
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 0022-3085
EI 1933-0693
J9 J NEUROSURG
JI J. Neurosurg.
PD JUL
PY 2020
VL 133
IS 1
BP 144
EP 151
DI 10.3171/2019.2.JNS183159
PG 8
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA OK0VT
UT WOS:000584371500029
PM 31075782
DA 2026-01-16
ER

PT J
AU Maindet, C
   Burnod, A
   Minello, C
   George, B
   Allano, G
   Lemaire, A
AF Maindet, Caroline
   Burnod, Alexis
   Minello, Christian
   George, Brigitte
   Allano, Gilles
   Lemaire, Antoine
TI Strategies of complementary and integrative therapies in cancer-related
   painattaining exhaustive cancer pain management
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Pain management; Personalized management; Multimorphic pain; Cancer
   pain; Mind-body therapy; Complementary therapies
ID QUALITY-OF-LIFE; COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED
   CONTROLLED-TRIAL; BREAST-CANCER; PHYSICAL-ACTIVITY; LONG-TERM;
   ALTERNATIVE MEDICINE; STRESS REDUCTION; VIRTUAL-REALITY; MINDFULNESS
   MEDITATION
AB PurposeComplementary integrative therapies (CITs) correspond to growing demand in patients with cancer-related pain. This demand needs to be considered alongside pharmaceutical and/or interventional therapies. CITs can be used to cover certain specific pain-related characteristics. The objective of this review is to present the options for CITs that could be used within dynamic, multidisciplinary, and personalized management, leading to an integrative oncology approach.MethodsCritical reflection based on literature analysis and clinical practice.ResultsMost CITs only showed trends in efficacy as cancer pain was mainly a secondary endpoint, or populations were restricted. Physical therapy has demonstrated efficacy in motion and pain, in some specific cancers (head and neck or breast cancers) or in treatments sequelae (lymphedema). In cancer survivors, higher levels of physical activity decrease pain intensity. Due to the multimorphism of cancer pain, certain mind-body therapies acting on anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, healing touch, hypnosis, and music therapy) are efficient on cancer pain. Other mind-body therapies have shown trends in reducing the severity of cancer pain and improving other parameters, and they include education (with coping skills training), yoga, tai chi/qigong, guided imagery, virtual reality, and cognitive-behavioral therapy alone or combined. The outcome sustainability of most CITs is still questioned.ConclusionsHigh-quality clinical trials should be conducted with CITs, as their efficacy on pain is mainly based on efficacy trends in pain severity, professional judgment, and patient preferences. Finally, the implementation of CITs requires an interdisciplinary team approach to offer optimal, personalized, cancer pain management.
C1 [Maindet, Caroline] Grenoble Alpes Univ Hosp, Pain Management Ctr, Grenoble, France.
   [Burnod, Alexis] PSL Res Univ, Inst Curie, Dept Support Care, Paris, France.
   [Minello, Christian] Canc Ctr Georges Francois Leclerc, Anaesthesia Intens Care Dept, Dijon, France.
   [George, Brigitte] St Louis Hosp, Pain Management Unit, Paris, France.
   [Allano, Gilles] Mutualist Clin Porte de Orient, Pain Management Unit, Lorient, France.
   [Lemaire, Antoine] Valenciennes Gen Hosp, Oncol & Med Specialties Dept, Valenciennes, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; UNICANCER; Universite PSL; Institut Curie;
   UNICANCER; Universite Bourgogne Europe; Centre Georges-Francois Leclerc;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Saint-Louis - APHP; CH de Valenciennes
RP Lemaire, A (corresponding author), Valenciennes Gen Hosp, Oncol & Med Specialties Dept, Valenciennes, France.
EM lemaire-a@ch-valenciennes.fr
RI lemaire, antoine/AID-4462-2022
OI lemaire, antoine/0000-0002-3612-5388
FU Kyowa Kirin
FX This article was funded by Kyowa Kirin.
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NR 158
TC 56
Z9 67
U1 1
U2 93
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD AUG
PY 2019
VL 27
IS 8
BP 3119
EP 3132
DI 10.1007/s00520-019-04829-7
PG 14
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA IF6QA
UT WOS:000473204000041
PM 31076901
DA 2026-01-16
ER

PT J
AU Kim, K
   Lee, S
AF Kim, Kyungsuk
   Lee, Sanghun
TI Intradermal Acupuncture Along with Analgesics for Pain Control in
   Advanced Cancer Cases: A Pilot, Randomized, Patient-Assessor-Blinded,
   Controlled Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; intradermal; advanced cancer; analgesics; pain management
ID QUALITY-OF-LIFE; CELL LUNG-CANCER; AURICULAR ACUPUNCTURE;
   CLINICAL-TRIALS; SAMPLE-SIZE; MANAGEMENT; COMPLEMENTARY; PREVALENCE;
   MEDICINE; QLQ-C30
AB Purpose: Ninety percent of patients with advanced cancer have moderate to severe pain, and up to 70% of patients with cancer pain do not receive adequate pain relief. This randomized controlled clinical trial was designed to determine the feasibility and evaluate the effects and safety of intradermal acupuncture (IA) in patients who were being administered analgesics for cancer pain. Methods: Advanced cancer patients experiencing pain were randomly assigned to IA or sham IA treatment for 3 weeks (15 patients for each group), wherein the CV12, bilateral ST25, LI4, LR3, PC06, and Ashi points were selected and stimulated. Follow-up evaluations were conducted 3 weeks after the end of treatments. The grade and dosage of analgesics for cancer pain, pain intensity, quality of life, and safety were assessed. Results: Twenty-seven patients (90%) completed 6-week trial, and no serious adverse events were associated with either IA or sham IA procedures except the transient side effect such as fatigue. Nine patients in the IA group (64.3%) and 5 in the sham IA group (38.5%) responded to the 3-week intervention. These patients were mostly in the nonopioid and the weak opioid levels of the World Health Organization analgesic ladder. Self-reported pain declined by -1.54 +/- 1.45 and -1.15 +/- 1.57 in the IA and sham IA groups, respectively, with improved quality of life reported. Conclusions: IA treatment appears feasible and safe for advanced cancer patients. It might reduce analgesic usage in the early World Health Organization analgesic ladder stage cancer patient, though it could not show significant outcome differences due to design limitation of sham IA.
C1 [Kim, Kyungsuk; Lee, Sanghun] Dankook Univ, Grad Sch, Dept Med Consilience, 152 Jukjeon Ro, Yongin 16890, Gyeonggi Do, South Korea.
C3 Dankook University
RP Lee, S (corresponding author), Dankook Univ, Grad Sch, Dept Med Consilience, 152 Jukjeon Ro, Yongin 16890, Gyeonggi Do, South Korea.
EM integrative@korea.com
OI Lee, Sanghun/0000-0002-0573-9555
FU Ministry of Science, ICT and Future Planning through the National
   Research Foundation [NRF-2017M3A9C4065964]; Comprehensive and
   Integrative Medicine Institute (CIMI), Daegu, Republic of Korea
   [CIMI-15-01-07]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the Bio-Synergy Research Project (NRF-2017M3A9C4065964)
   of the Ministry of Science, ICT and Future Planning through the National
   Research Foundation; and the Comprehensive and Integrative Medicine
   Institute (CIMI), Daegu, Republic of Korea (Grant #CIMI-15-01-07).
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NR 33
TC 30
Z9 37
U1 1
U2 35
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD DEC
PY 2018
VL 17
IS 4
BP 1137
EP 1143
DI 10.1177/1534735418786797
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA HA5OG
UT WOS:000450322400016
PM 30009652
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, XJ
   Gong, J
   Jin, LM
   Liu, L
   Sun, JB
   Qin, W
AF Yang, Xuejuan
   Gong, Jie
   Jin, Lingmin
   Liu, Lin
   Sun, Jinbo
   Qin, Wei
TI Effect of catechol-O-methyltransferase Val158Met polymorphism on
   resting-state brain default mode network after acupuncture stimulation
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article
DE Acupuncture; COMT Val158Met polymorphism; Default mode network;
   Connectivity; Resting-state
ID FUNCTIONAL CONNECTIVITY; ELECTROACUPUNCTURE ANALGESIA; VAL(158)MET
   GENOTYPE; COMT VAL(158)MET; CLINICAL-EFFICACY; CANCER PAIN; MODULATION;
   RESPONSES; GENE; MORPHINE
AB The effects of acupuncture can be characterized by clear individual differences. Several revealing studies suggest an underlying role of inherited genetic factor in interindividual variability in response to acupuncture treatment. It remains unclear, however, if the modulation of acupuncture on resting brain function is influenced by genetic factors. Catechol-o-methyltransferase (COMT) Val158Met polymorphism has been shown to regulate the resting brain network, especially in the default mode network (DMN), which is a target area that responds to acupuncture stimulation. Therefore, the present study investigated the effect of COMT Val158Met polymorphism on the modulation of acupuncture in DMN connectivity in healthy Chinese young adults. Using mixed-design ANOVA analysis, we found a significant interactive effect between acupuncture and the COMT gene. For subjects carrying the Val/Met genotype, acupuncture induced decreased DMN connectivity with the left middle frontal gyrus during the post-acupuncture stage compared with the pre-acupuncture stage, which was not observed in Val/Val homozygous subjects. These results demonstrated that during sustained periods after acupuncture stimulation, the brain network is likely under genetic control, and COMT might be a candidate gene that regulates the resting DMN response to acupuncture stimulation.
C1 [Yang, Xuejuan; Gong, Jie; Jin, Lingmin; Liu, Lin; Sun, Jinbo; Qin, Wei] Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China.
C3 Xidian University
RP Qin, W (corresponding author), Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China.
EM wqin@xidian.edu.cn
RI JinBo, Sun/GLT-2082-2022; Wei, QIN/I-5673-2014
FU National Basic Research Program of China [2014CB543203, 2015CB856403];
   National Natural Science Foundation of China [81471811, 61401346,
   81271644]
FX This study was financially supported by National Basic Research Program
   of China under Grant Nos. 2014CB543203 and 2015CB856403, and the
   National Natural Science Foundation of China under Grant Nos., 81471811,
   61401346 and 81271644.
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NR 58
TC 5
Z9 6
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1931-7557
EI 1931-7565
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD JUN
PY 2018
VL 12
IS 3
BP 798
EP 805
DI 10.1007/s11682-017-9735-6
PG 8
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GI6PB
UT WOS:000434491400016
PM 28608189
DA 2026-01-16
ER

PT J
AU Fu, JY
   Xie, XX
   Yao, HM
   Xiao, HJ
   Li, ZQ
   Wang, ZZ
   Ju, R
   Zhao, Y
   Liu, ZJ
   Zhang, NA
AF Fu, Jingya
   Xie, Xiaoxia
   Yao, Huimin
   Xiao, Haijuan
   Li, Zhuoqun
   Wang, Zhenzhi
   Ju, Ran
   Zhao, Yan
   Liu, Zhijun
   Zhang, Nana
TI The Effectiveness of Traditional Chinese Medicine in Treating
   Malignancies via Regulatory Cell Death Pathways and the Tumor Immune
   Microenvironment: A Review of Recent Advances
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Traditional Chinese Medicine; Cell Death Modality; Tumor Immune
   Microenvironment; Clinical Application; Immunotherapy
ID BONE CANCER PAIN; NEURONAL INJURY; AUTOPHAGY; TFEB; ACUPUNCTURE;
   MECHANISMS; MANAGEMENT
AB Traditional Chinese Medicine (TCM) has achieved high clinical efficacy in treating malignancies in recent years and is thus gradually becoming an important therapy for patients with advanced tumor for its benefits in reducing side effects and improving patients' immune status. However, it has not been internationally recognized for cancer treatment because TCM's anti-tumor mechanism is not fully elucidated, limiting its clinical application and international promotion. This review traced the mechanism of the TCM-mediated tumor cell death pathway and its effect on remodeling the tumor immune microenvironment, its direct impact on the microenvironment, its anti-tumor effect in combination with immunotherapy, and the current status of clinical application of TCM on tumor treatment. TCM can induce tumor cell death in many regulatory cell death (RCD) pathways, including apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. In addition, TCM-induced cell death could increase the immune cells' infiltration with an anti-tumor effect in the tumor tissue and elevate the proportion of these cells in the spleen or peripheral blood, enhancing the anti-tumor capacity of the tumor-bearing host. Moreover, TCM can directly affect immune function by increasing the population or activating the sub-type immune cells with an anti-tumor role. It was concluded that TCM could induce a pan-tumor death modality, remodeling the local TIME differently. It can also improve the systemic immune status of tumor-bearing hosts. This review aims to establish a theoretical basis for the clinical application of TCM in tumor treatment and to provide a reference for TCM's potential in combination with immunotherapy in cancer treatment.
C1 [Fu, Jingya; Xie, Xiaoxia; Yao, Huimin; Wang, Zhenzhi; Ju, Ran; Zhao, Yan; Liu, Zhijun; Zhang, Nana] Xi An Jiao Tong Univ, Affiliated Hosp 1, Inst Regenerat & Reconstruct Med, Med X Inst, Xian 710049, Peoples R China.
   [Fu, Jingya; Xie, Xiaoxia; Xiao, Haijuan; Wang, Zhenzhi] Shaanxi Univ Chinese Med, Xianyang 712046, Peoples R China.
   [Yao, Huimin; Li, Zhuoqun; Ju, Ran; Zhao, Yan; Liu, Zhijun; Zhang, Nana] Xi An Jiao Tong Univ, Affiliated Hosp 1, Natl Local Joint Engn Res Ctr Precis Surg & Regene, Xian 710049, Peoples R China.
   [Yao, Huimin; Li, Zhuoqun; Ju, Ran; Zhao, Yan; Liu, Zhijun; Zhang, Nana] Xi An Jiao Tong Univ, Affiliated Hosp 1, Shaanxi Prov Ctr Regenerat Med & Surg Engn, Xian 710061, Peoples R China.
   [Fu, Jingya] Nanyang Med Coll, Affiliated Hosp 1, Nanyang 473000, Peoples R China.
   [Liu, Zhijun; Zhang, Nana] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst,Inst Regenerat & Reconstruct Med, Natl Local Joint Engn Res Ctr Precis Surg & Regene, 227 West Yanta Rd, Xian 710049, Peoples R China.
C3 Xi'an Jiaotong University; Shaanxi University of Chinese Medicine; Xi'an
   Jiaotong University; Xi'an Jiaotong University; Nanyang Medical College;
   Xi'an Jiaotong University
RP Liu, ZJ; Zhang, NA (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst,Inst Regenerat & Reconstruct Med, Natl Local Joint Engn Res Ctr Precis Surg & Regene, 227 West Yanta Rd, Xian 710049, Peoples R China.
RI Li, Zhuoqun/KHE-1469-2024
OI 赵, 妍/0009-0000-1333-6193; Fu, Jingya/0009-0002-3195-1960; Liu,
   Zhijun/0000-0003-1006-7893; Ju, Ran/0009-0002-0379-4734
FU Institutional Foundation of The First Affiliated Hospital of Xi'an
   Jiaotong University [2021QN-23]; Project of Shaanxi Province Natural
   Science Basic Research [2022JQ-914]
FX We want to thank the website of https://app.biorender.com/ for providing
   cell morpho-logical elements used to complete our Fig.1. And Fig.1was
   created with Bio Render.com. This study was supported by the
   Institutional Foundation of The First Affiliated Hospital of Xi'an
   Jiaotong University (NO. 2021QN-23) and the Project of Shaanxi Province
   Natural Science Basic Research (NO. 2022JQ-914).
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NR 85
TC 12
Z9 13
U1 11
U2 31
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 01
BP 231
EP 252
DI 10.1142/S0192415X2450006X
EA FEB 2024
PG 22
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA KR9I7
UT WOS:001163194700003
PM 38328830
DA 2026-01-16
ER

PT J
AU Li, S
   Dai, AH
   Zhou, YH
   Chen, X
   Chen, YZ
   Zhou, L
   Yang, XL
   Yue, MQ
   Shi, J
   Qiu, Y
AF Li, Song
   Dai, Anhong
   Zhou, Yihao
   Chen, Xu
   Chen, Yizhou
   Zhou, Li
   Yang, Xiaolin
   Yue, Mengqi
   Shi, Jing
   Qiu, Yong
TI Hotspots and trends in acupuncture combined with non-invasive
   neuromodulation technology in the past 20 years: a bibliometric analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE acupuncture; non-invasive neuromodulation technology; transcutaneous
   electrical acupoint stimulation; analgesia; visualization analysis;
   bibliometric
ID ELECTRICAL ACUPOINT STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION;
   GENERAL-ANESTHESIA; PAIN; THERAPY; ELECTROACUPUNCTURE; RECOVERY; CANCER;
   PRETREATMENT; MODULATION
AB Background: Non-invasive neuromodulation (NIN) technology, a promising approach in the field of neuromodulation, has been employed to address a diverse array of disorders, with an increasing volume of research emerging. Traditional Chinese acupuncture has also been utilized as a complementary and preventive therapy for various ailments. Nevertheless, the publication trends and research hotspots at the intersection of acupuncture and NIN technology remain largely unexplored. This study aims to systematically analyze the publication trends and research hotspots related to the convergence of acupuncture and NIN over the past two decades using bibliometric methods. Methods: We collected literature data on the combination of acupuncture and NIN technology from January 1, 2004, to December 31, 2023, utilizing the Web of Science Core Collection (WOSCC) database. This data was imported into CiteSpace (version 6.2. R4) and RStudio to facilitate a visual analysis of research hotspots and trends, categorized by author, country/region, affiliation, annual publication, keywords, and journal. Results: A total of 803 articles were retrieved, encompassing contributions from 55 countries, 468 research institutions, and 360 academic journals. The People's Republic of China leads in publication volume with 390 articles, followed by Capital Medical University and Peking University, each contributing 27 articles. Among the authors, HAN JS has the highest number of co-citations, totaling 142. Additionally, the journal Evidence-Based Complementary and Alternative Medicine is noted for publishing the most papers in this field. Recent research hotspots regarding acupuncture combined with NIN technology primarily focus on topics such as "postoperative gastrointestinal function," "postoperative analgesia," "postoperative nausea and vomiting," "acupuncture analgesia," "reproductive medicine," "inflammation," "chronic low back pain," and "postoperative pain." The predominant intervention method identified is TEAS technology, which integrates acupuncture with modern electrical stimulation as an innovative clinical treatment approach. Conclusion: The publications on acupuncture combined with NIN technology have made significant progress; however, there is still a need to strengthen international academic exchanges and cooperation among scientific researchers and institutions to promote interdisciplinary collaboration and academic innovation. Furthermore, future studies should focus on enhancing the overall quality of research outcomes in this field and reinforcing research programs.
C1 [Li, Song] Heilongjiang Univ Chinese Med, Clin Med Coll 2, Harbin, Peoples R China.
   [Li, Song; Zhou, Yihao; Shi, Jing] Yunnan Univ Chinese Med, Affiliated Hosp 1, Yunnan Prov Hosp Tradit Chinese Med, Dept Acupuncture & Moxibust, Kunming, Peoples R China.
   [Dai, Anhong] Kunming Med Univ, Yanan Hosp, Dept Rehabil Med, Kunming, Peoples R China.
   [Chen, Xu; Chen, Yizhou; Zhou, Li; Yang, Xiaolin; Yue, Mengqi; Qiu, Yong] Yunnan Univ Tradit Chinese Med, Kunming, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Yunnan University of
   Chinese Medicine; Kunming Medical University; Yunnan University of
   Chinese Medicine
RP Shi, J (corresponding author), Yunnan Univ Chinese Med, Affiliated Hosp 1, Yunnan Prov Hosp Tradit Chinese Med, Dept Acupuncture & Moxibust, Kunming, Peoples R China.; Qiu, Y (corresponding author), Yunnan Univ Tradit Chinese Med, Kunming, Peoples R China.
EM 2662831291@qq.com; 2225851674@qq.com
RI Dai, Anhong/HPB-7691-2023
FU National Natural Science Foundation of China [81760893]; Fundamental
   Research Key Project of Yunnan Science and Technology Department
   [202101AZ070001-165]; Special Project for Famous Doctors of "Xingdian
   Talent Support Program" in Yunnan Province
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This study received funding
   from National Natural Science Foundation of China, No. 81760893, JS;
   Fundamental Research Key Project of Yunnan Science and Technology
   Department, 202101AZ070001-165, JS. The Special Project for Famous
   Doctors of "Xingdian Talent Support Program" in Yunnan Province, JS.
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NR 71
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD SEP 9
PY 2025
VL 16
AR 1511655
DI 10.3389/fneur.2025.1511655
PG 18
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 7RN2X
UT WOS:001577946900001
PM 40994712
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Pan, YQ
   Yong, T
   Liang, HQ
   Gen, C
   Shen, XP
   Dong, J
   Qi, C
   Qi, MM
AF Yuanqing, Pan
   Yong, Tang
   Haiqian, Liang
   Gen, Chen
   Shen, Xiping
   Dong, Jin
   Qi, Cui
   Miaomiao, Qi
TI Acupuncture for Hormone Therapy-Related Side Effects in Breast Cancer
   Patients: A GRADE-Assessed Systematic Review and Updated Meta-Analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE breast cancer; acupuncture; meta-analysis; alternative therapy; GRADE
ID MYOFASCIAL TRIGGER POINTS; CONTROLLED-TRIAL; HOT FLASHES; VASOMOTOR
   SYMPTOMS; APPLIED RELAXATION; JOINT SYMPTOMS; WOMEN; ELECTROACUPUNCTURE;
   FATIGUE; CHEMOTHERAPY
AB Purpose:To determine the efficacy of acupuncture on the management of hormone therapy-related side effects in breast cancer patients.Methods:Randomized controlled trials of acupuncture versus a control or placebo in breast cancer patients that examined reductions in therapy-related side effects were retrieved from PubMed, EMBASE, Web of Science, and the Cochrane Library through April 2020. Data on patient symptoms (hot flashes, fatigue, pain, stiffness, and gastrointestinal symptoms), physical capacity, cytokines, and general psychosomatic well-being were analyzed. We evaluated and analyzed the quality of all included studies with the 5.2 Cochrane Handbook standards using Stata software (version 10.0) and Revman software (version 5.2), respectively. We assessed the risk of bias using the Cochrane Risk of Bias tool and evaluated the quality of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach.Results:The pooled results suggested that acupuncture led to moderate improvements in hot flashes, fatigue, and stiffness. No significant differences were observed in pain, gastrointestinal symptoms, Kupperman index scores, Overall quality of life, tumor necrosis factor levels, and interleukin levels.Conclusions:Evidence for outcome indicators of symptom management were downgraded by the GRADE system for inconsistency, indirectness, and imprecision in the included RCTs. Nonetheless, acupuncture is a moderately appropriate alternative therapy for hormone therapy-related side effects in breast cancer patients. However, it still lacks large-sample, multicenter, prospective RCTs. Future research should focus on standardizing comparison groups and treatment methods, be at least single-blinded, assess biologic mechanisms, have adequate statistical power, and involve multiple acupuncturists.
C1 [Yuanqing, Pan; Gen, Chen] Guilin Med Univ, Campbell China Network, Guilin, Peoples R China.
   [Yong, Tang] Tianjin Med Univ, Affiliated Tumor Hosp, Tianjin, Peoples R China.
   [Haiqian, Liang] Characterist Med Ctr Chinese Peoples Armed Police, Tianjin, Peoples R China.
   [Shen, Xiping; Miaomiao, Qi] Lanzhou Univ, Lanzhou, Gansu, Peoples R China.
   [Dong, Jin] Tianjin Pingjin Hosp, Tianjin, Peoples R China.
   [Qi, Cui] Lanzhou Univ, Affiliated Hosp 1, Lanzhou, Gansu, Peoples R China.
C3 Guilin Medical University; Tianjin Medical University; Lanzhou
   University; Lanzhou University
RP Pan, YQ (corresponding author), Sch Humanities & Management, Dept Med Psychol, 1 Zhiyuan Rd, Guilin 541000, Peoples R China.
EM panyuanq@126.com
OI Pan, Yuanqing/0000-0002-6823-9566
FU Undergraduate teaching reform project of Guangxi higher education in
   2020: exploration on the cultivation of undergraduates' preclinical
   research reserve ability based on evidence-based medicine; Guangxi
   science and technology plan project (Guangxi science and technology base
   and special talent program): an evidence-based evaluation study of the
   GRADE system in the evidence system of non-drug complementary
   alternative medicine
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: We are
   indebted to the following education and research institutions for
   financial support. (1) Undergraduate teaching reform project of Guangxi
   higher education in 2020: exploration on the cultivation of
   undergraduates' preclinical research reserve ability based on
   evidence-based medicine. (2) Guangxi science and technology plan project
   (Guangxi science and technology base and special talent program): an
   evidence-based evaluation study of the GRADE system in the evidence
   system of non-drug complementary alternative medicine.
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NR 49
TC 11
Z9 14
U1 0
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUL
PY 2020
VL 19
AR 1534735420940394
DI 10.1177/1534735420940394
PG 17
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA MV8LE
UT WOS:000556601500001
PM 32718258
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, WM
   Wang, XL
   Liu, Y
   Sun, YJ
   Liu, XX
   Yan, Y
   Liu, ZS
AF Wang, Weiming
   Wang, Xinlu
   Liu, Yan
   Sun, Yuanjie
   Liu, Xiaoxu
   Yan, Yan
   Liu, Zhishun
TI Effects of Electroacupuncture on Opioid-Induced Constipation in Patients
   With Cancer: Study Protocol for a Multicenter Randomized Controlled
   Trial
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE opioid-induced constipation; acupuncture; cancer patients; randomized
   controlled trial; spontaneous bowel movements
ID BOWEL DYSFUNCTION; MANAGEMENT; EFFICACY; IMPACT; PAIN; RECOMMENDATIONS;
   PRUCALOPRIDE; ACUPUNCTURE; DIAGNOSIS; EVENTS
AB Background: Opioid-induced constipation (OIC) is one of the most prevalent adverse events associated with cancer patients who receive opioid analgesics for moderate to severe pain. Acupuncture may be an effective treatment for OIC. We designed this trial to assess the efficacy and safety of electroacupuncture for OIC in cancer patients. Methods: This is a multicenter, sham-controlled, parallel-group, subject- and assessor-blinded randomized trial. A total of 100 cancer patients with OIC will be randomly assigned to either the electroacupuncture group or the sham electroacupuncture group at a ratio of 1:1. Patients in each group will receive a total of 24-session treatment over 8 weeks, three sessions a week and 30 min each session. Thereafter, patients will be followed up for another 8 weeks. The primary outcome will be the proportion of responders, defined as a patient who has >= 3 spontaneous bowel movements (SBMs)/wk and >= increase of 1 SBM from baseline simultaneously for at least 6 out of 8 weeks of the treatment period. The secondary outcomes will include the mean weekly SBMs and complete spontaneous bowel movements, the mean Bristol Stool Form Scale score for stool consistency, the mean score for straining of SBM, the total and subscale scores of Patient Assessment of Constipation-Symptom questionnaires, and the total and subscale scores of Patient Assessment of Constipation-Quality of Life questionnaire. Patients' global assessment of treatment effectiveness, patients' expectation toward the effectiveness of acupuncture and safety of acupuncture will also be assessed. All efficacy analyses will be performed in the intention-to-treat population. Discussion: To improve the adherence to intervention protocols, the majority of the participants will be recruited from an inpatient setting. The results will help to determine the clinical effects and safety of electroacupuncture for the treatment of OIC among patients with cancer.
EM zhishunjournal@163.com
RI Wang, Xinlu/OFN-6913-2025
FU 2019 National Administration of Traditional Chinese Medicine Project of
   building evidence-based practice capacity for TCM-Project BEBPC-TCM
   [2019XZZX-ZJ]
FX This study was supported and funded by the 2019 National Administration
   of Traditional Chinese Medicine Project of building evidence-based
   practice capacity for TCM-Project BEBPC-TCM (No. 2019XZZX-ZJ). The
   funders had no role in the planning, study design, execution, or
   analysis of the work.
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NR 41
TC 3
Z9 3
U1 4
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 13
PY 2022
VL 9
AR 818258
DI 10.3389/fmed.2022.818258
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1Y3NQ
UT WOS:000808050500001
PM 35492306
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Pan, YQ
   Yang, KH
   Shi, X
   Liang, HQ
   Shen, XP
   Wang, RJ
   Ma, L
   Cui, Q
   Yu, RZ
   Dong, Y
AF Pan, Yuanqing
   Yang, Kehu
   Shi, Xiue
   Liang, Haiqian
   Shen, Xiping
   Wang, Renjie
   Ma, Li
   Cui, Qi
   Yu, Runze
   Dong, Yi
TI Clinical Benefits of Acupuncture for the Reduction of Hormone
   Therapy-Related Side Effects in Breast Cancer Patients: A Systematic
   Review
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; hormone therapy-related side effects; breast cancer;
   systematic review; quality of life
ID RANDOMIZED CONTROLLED-TRIAL; TREATING HOT FLASHES; ALTERNATIVE MEDICINE;
   AROMATASE INHIBITORS; MUSCULOSKELETAL SYMPTOMS; POSTMENOPAUSAL WOMEN;
   APPLIED RELAXATION; JOINT SYMPTOMS; TNF-ALPHA; ELECTROACUPUNCTURE
AB Importance. Acupuncture can help reduce unpleasant side effects associated with endocrine therapy for breast cancer. Nevertheless, comprehensive evaluation of current evidence from randomized controlled trials(RCTs) is lacking. Objective. To estimate the efficacy of acupuncture for the reduction of hormone therapy-related side effects in breast cancer patients. Evidence review. RCTs of acupuncture in breast cancer patients that examined reductions in hormone therapy-related side effects were retrieved from PubMed, EMBASE, Web of Science, Ovid MEDLINE, and Cochrane Library databases through April 2016. The quality of the included studies was evaluated according to the 5.2 Cochrane Handbook standards, and CONSORT and STRICTA (Revised Standards for Reporting Interventions in Clinical Trials of Acupuncture) statements. Intervention. Interventions included conventional acupuncture treatment compared with no treatment, placebo, or conventional pharmaceutical medication. Major outcome measures were the alleviation of frequency and symptoms and the presence of hormone therapy-related side effects. Findings/Results. A total of 17 RCTs, including a total of 810 breast cancer patients were examined. The methodological quality of the trials was relatively rigorous in terms of randomization, blinding, and sources of bias. Compared with control therapies, the pooled results suggested that acupuncture had moderate effects in improving stiffness. No significant differences were observed in hot flashes, fatigue, pain, gastrointestinal symptoms, Kupperman index, general well-being, physical well-being, tumor necrosis factor (TNF), and interleukin (IL). Conclusions. Acupuncture therapy appears to be potentially useful in relieving functional stiffness. However, further large-sample trials with evidence-based design are still needed to confirm these findings.
C1 [Pan, Yuanqing; Yu, Runze; Dong, Yi] Tianjin Med Coll, Tianjin, Peoples R China.
   [Pan, Yuanqing; Yang, Kehu; Shen, Xiping] Lanzhou Univ, Lanzhou, Gansu, Peoples R China.
   [Shi, Xiue] Gansu Rehabil Ctr Hosp, Lanzhou, Gansu, Peoples R China.
   [Liang, Haiqian; Wang, Renjie] Tianjin Pingjin Hosp, Tianjin, Peoples R China.
   [Ma, Li] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China.
   [Cui, Qi] Lanzhou Univ, Affiliated Hosp 1, Lanzhou, Gansu, Peoples R China.
C3 Tianjin Medical University; Lanzhou University; Tianjin Medical
   University; Lanzhou University
RP Yang, KH (corresponding author), Lanzhou Univ, WHO Guide Implementat & Knowledge Convers Coopera, Sch Basic Med Sci, Evidence Based Med Ctr,Key Lab Clin Translat Res, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM kehuyangebm2006@126.com
OI Yang, Hehu/0000-0001-7864-3012
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NR 49
TC 21
Z9 26
U1 0
U2 35
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2018
VL 17
IS 3
BP 602
EP 618
DI 10.1177/1534735418786801
PG 17
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA GQ8BY
UT WOS:000441976400003
PM 30117343
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zeng, YJ
   Lin, YH
   Wang, YC
   Chang, JH
   Wu, JH
   Hsu, SF
   Tsai, SY
   Lin, CH
   Wen, YR
AF Zeng, Yen-Jing
   Lin, Yu-Hsiang
   Wang, You-Cheng
   Chang, Ju-Hsin
   Wu, Jih-Huah
   Hsu, Sheng-Feng
   Tsai, Shih-Ying
   Lin, Ching-Huang
   Wen, Yeong-Ray
TI Laser acupuncture-induced analgesic effect and molecular alterations in
   an incision pain model: a comparison with electroacupuncture-induced
   effects
SO LASERS IN MEDICAL SCIENCE
LA English
DT Article
DE Laser acupuncture; Postoperative pain; MAPK; iNOS; TNF
ID POSTOPERATIVE PAIN; THERMAL HYPERALGESIA; MANAGEMENT; MICROGLIA; KINASE;
   INJURY; RATS
AB Low-level laser acupuncture (LLLA) produces photobiomodulation through acupuncture point and is an alternative to low-level laser therapy. Although the analgesic effect of LLLA on chronic pain has been proven, its effect on acute postincisional pain has yet to be investigated. A plantar incision (PI) model was used to mimic human postsurgical pain. Male adult rats received GaAlAs laser irradiation at the right ST36 acupoint immediately after operation and on the following 4 days. Three laser treatment groups (two red laser groups with a 30- or 15-min treatment duration and one 30-min near-infrared laser group) were compared with sham LLLA and naive groups and an electroacupuncture (EA) group (separate study). Behavioral withdrawal thresholds of both hind paws were measured before and after incision. Expression of mitogen-activated protein kinases (p-ERK and p-p38), inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF) in the spinal cord was analyzed. All three LLLA treatments attenuated post-PI tactile allodynia in the ipsilateral paw, but only the 30-min red laser treatment affected the contralateral paw and had similar efficacy to that of EA. All laser treatments barely reduced heat hyperalgesia in both hind paws. At 3 days after PI, the 30-min red laser group showed reversed increases of PI-induced p-ERK, p-p38, and iNOS but not TNF expression in the spinal cord. Repetitive LLLA treatments ameliorated PI-induced mechanical pain. The inhibition of multiple sensitization signals highlights the unique clinical role of LLLA. Thus, LLLA is an alternative to EA as an adjuvant for postoperative pain control.
C1 [Zeng, Yen-Jing; Chang, Ju-Hsin] China Med Univ, Coll Med, Grad Inst Clin Med, Taichung, Taiwan.
   [Lin, Yu-Hsiang; Lin, Ching-Huang] Natl Yunlin Univ Sci & Technol, Microelect & Optoelect Engn Dept Elect Engn, Touliu, Yunlin, Taiwan.
   [Wang, You-Cheng; Lin, Ching-Huang] Natl Yunlin Univ Sci & Technol, Dept Elect Engn, Touliu, Yunlin, Taiwan.
   [Chang, Ju-Hsin; Tsai, Shih-Ying; Wen, Yeong-Ray] China Med Univ Hosp, Dept Anesthesiol, 2 Yuh Der Rd, Taichung 40447, Taiwan.
   [Wu, Jih-Huah] Ming Chuan Univ, Dept Biomed Engn, Taipei, Taiwan.
   [Hsu, Sheng-Feng; Wen, Yeong-Ray] China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, Taichung, Taiwan.
   [Hsu, Sheng-Feng] China Med Univ Hosp, Taipei Branch, Dept Acupuncture, Taipei, Taiwan.
   [Hsu, Sheng-Feng; Wen, Yeong-Ray] China Med Univ, Acupuncture Res Ctr, Taichung, Taiwan.
   [Wen, Yeong-Ray] China Med Univ, Sch Med, Dept Anesthesiol, Taichung, Taiwan.
   [Wen, Yeong-Ray] China Med Univ, Sch Med, Dept Anesthesiol, Ctr Pain Res & Management, Taichung, Taiwan.
C3 China Medical University Taiwan; National Yunlin University Science &
   Technology; National Yunlin University Science & Technology; China
   Medical University Taiwan; China Medical University Hospital - Taiwan;
   Ming Chuan University; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan
RP Wen, YR (corresponding author), China Med Univ Hosp, Dept Anesthesiol, 2 Yuh Der Rd, Taichung 40447, Taiwan.; Wen, YR (corresponding author), China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, Taichung, Taiwan.; Wen, YR (corresponding author), China Med Univ, Acupuncture Res Ctr, Taichung, Taiwan.; Wen, YR (corresponding author), China Med Univ, Sch Med, Dept Anesthesiol, Taichung, Taiwan.; Wen, YR (corresponding author), China Med Univ, Sch Med, Dept Anesthesiol, Ctr Pain Res & Management, Taichung, Taiwan.
EM yr.wen@yahoo.com.tw
RI Wen, Yeong-Ray/G-3991-2013; Wu, Jih-Huah/ABR-2245-2022
OI Wen, Yeong-Ray/0000-0003-2023-6523; 
FU National Science Council in Taiwan [NSC101-2314-B-039-005-MY3]; Taiwan
   Ministry of Health and Welfare Clinical Trial Center
   [MOHW106-TDU-B-212-113004]; China Medical University Hospital
   [DMR-106-217, DMR-106-181];  [MOST 104-2314-B-039-020-MY2];  [MOST
   105-2320-B-039-029]
FX Each author had participated sufficiently in the study, and all took
   public responsibility for appropriate portions of the content. Dr. Wen,
   Dr. Lin, and Dr. Hsu designed the whole study conception together. Ms.
   Wang and Mr. Lin performed behavioral tests, collected the data, and
   analyzed the data with Dr. Zeng. Dr. Zeng, Dr. Chang, Dr. Tsai, and Dr.
   Wen discussed and interpreted all the data. Mrs. Zeng, Dr. Tsai, and Dr.
   Wen drafted the manuscript. Dr. Wen wrote the final manuscript and Dr.
   Wu helped providing the critical opinions. Funding informationThis study
   was sponsored by research grants from the National Science Council in
   Taiwan (NSC101-2314-B-039-005-MY3), Minister of Science and Technology
   (MOST 104-2314-B-039-020-MY2), in part from Taiwan Ministry of Health
   and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004), in part
   from China Medical University Hospital (DMR-106-217) to Y.R. Wen, in
   part from Minister of Science and Technology (MOST 105-2320-B-039-029),
   and in part from China Medical University Hospital (DMR-106-181) to S.F.
   Hsu.
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NR 44
TC 27
Z9 29
U1 2
U2 18
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0268-8921
EI 1435-604X
J9 LASER MED SCI
JI Lasers Med. Sci.
PD FEB
PY 2018
VL 33
IS 2
BP 295
EP 304
DI 10.1007/s10103-017-2367-7
PG 10
WC Engineering, Biomedical; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Surgery
GA FV3HO
UT WOS:000424458900010
PM 29103083
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Ji, JF
   Guo, JX
   Chi, YL
   Su, F
AF Ji, Jiafu
   Guo, Jingxuan
   Chi, Yongliang
   Su, Fan
TI Cancer Pain Management with Traditional Chinese Medicine: Current Status
   and Future Perspectives
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Analgesic Ladder; Angelica dahurica; Angelicae pubescentis; Cancer Pain;
   Complementary Medicine; Corydalis yanhusuo; Cynanchum otophyllum;
   Ligusticum chuanxiong; Opioids; TCM Theory; Review
ID BONE PAIN; ACUPUNCTURE; MECHANISMS
AB Cancer pain, especially the moderate-to-severe pain experienced by patients with advanced cancer, is still one of the most challenging clinical problems. The current mainstream pharmacological treatment for cancer pain involves applying opioid medications and other pain-killing drugs. However, analgesic drugs have many adverse effects such as addiction, tolerance, and other formidable clinical and social issues. Thus, finding a new therapeutic approach to treat cancer pain is essential. Traditional Chinese medicine (TCM) has been increasingly applied in clinical practice because of its good efficacy and few side effects. However, its mechanisms of action in treating pain are still under investigation. The most important mechanism of cancer pain is that a large amount of pain-causing substances are secreted from cancer cells and promote their growth and invasion. The physical and chemical stimulations of these substances exist along with the cancer growth, leading to constantly increased pain sensation. Whether cancer pain can be alleviated by inhibiting cancer cells from releasing the substances and changing the microenvironment around the cancer mass, or even by eliminating pain-causing substances, is largely unknown. Based on TCM theory, this study reported that the aforementioned approach could effectively manage different cancer pains by tonifying qi, clearing and activating channels and meridians, and strengthening body resistance. The TCM therapies activate blood circulation, remove blood stasis, and nourish the heart. Commonly used Chinese herbal drugs include Corydalis yanhusuo, Angelica dahurica, and Ligusticum chuanxiong. Instead of using conventional analgesics to reduce pain, we should focus on using TCM modalities to alleviate cancer pain and increase the quality of life in patients suffering from cancer pain. TCM should provide us with a new strategy for managing cancer pain.
C1 [Ji, Jiafu; Guo, Jingxuan; Chi, Yongliang; Su, Fan] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Anesthesiol, Jinan 250014, Shandong, Peoples R China.
   [Chi, Yongliang; Su, Fan] Shandong Univ Tradit Chinese Med, Affiliated Hosp, 16369 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Chi, YL; Su, F (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, 16369 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
EM 15553156588@163.com; boatsail@163.com
RI guo, jingxuan/HJG-5818-2022
FU Science and Technology Innovation Development Plan of Jinan [202134068];
   New University 20 Research Leader Studio Project of Jinan [202228124];
   Key Program of TCM Technology of Shandong [Z-2022048]; Program of
   Shandong Province Nature Science Foundation [ZR2020MH391]
FX This work was supported by the Science and Technology Innovation
   Development Plan of Jinan (grant number 202134068 to Fan Su); the "New
   University 20" Research Leader Studio Project of Jinan (grant number
   202228124 to Fan Su); the Key Program of TCM Technology of Shandong (the
   grant number Z-2022048 to Yongliang Chi) and the Program of Shandong
   Province Nature Science Foundation (grant number ZR2020MH391 to Jiafu
   Ji).
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NR 50
TC 7
Z9 10
U1 4
U2 25
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 01
BP 123
EP 135
DI 10.1142/S0192415X24500058
EA JAN 2024
PG 13
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA KR9I7
UT WOS:001153777500001
PM 38281918
DA 2026-01-16
ER

PT J
AU Harvie, A
   Steel, A
   Wardle, J
AF Harvie, Alaia
   Steel, Arnie
   Wardle, Jon
TI Traditional Chinese Medicine Self-Care and Lifestyle Medicine Outside of
   Asia: A Systematic Literature Review
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE systematic review; Traditional Chinese Medicine; self-care; acupressure;
   acupuncture; lifestyle advice
ID CANCER-RELATED FATIGUE; CHRONIC NECK PAIN; CONTROLLED-TRIAL; EAR
   ACUPRESSURE; CLINICAL-TRIAL; UNITED-STATES; OLDER-ADULTS; ACUPUNCTURE;
   COMPLEMENTARY; NAUSEA
AB Background: Chinese medicine, when applied as a whole system of care, traditionally incorporates self-care techniques and patient understanding as key aspects of patient recovery and health maintenance. Objectives: This review aims to explore the literature to date on Traditional Chinese Medicine (TCM) self-care in settings outside of Asia, beyond the sole application of t'ai chi or qigong, to consider simple self-care techniques as health care interventions that may be generalized to a wider population. Design: AMED, CINAHL, EMBASE, PubMed, and MEDLINE databases were searched for articles from inception to July 2018. Studies were included, which were undertaken in settings outside of Asia and/or Asian communities, and were excluded if they solely examined t'ai chi or qigong. Results: Findings of the included studies (n = 37) were categorized into four key areas in relation to the TCM self-care component evaluated: self-acupressure, self-acupuncture, self-moxibustion, and the adoption of prescribed lifestyle, diet, and exercise advice based on a TCM diagnosis. The studies included randomized clinical trials, case studies, hospital audits, and qualitative evaluations. The studies assessed TCM self-care in relation to a wide range of health conditions, with the majority of studies concluding positive findings. Conclusion: This review draws attention to the potential role of TCM self-care techniques, in settings outside of Asia, beyond the sole practices of t'ai chi and qigong, as an adjunct to health maintenance and recovery. Only tentative conclusions can be drawn from the existing research, however, due to variability across studies in reporting transparency and the overall low number of studies retrieved. Further research is warranted.
C1 [Harvie, Alaia; Steel, Arnie; Wardle, Jon] Univ Technol Sydney, Fac Hlth, Bldg 10,Level 7,235 Jones St, Sydney, NSW 2007, Australia.
   [Steel, Arnie; Wardle, Jon] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW, Australia.
C3 University of Technology Sydney; University of Technology Sydney
RP Harvie, A (corresponding author), Univ Technol Sydney, Fac Hlth, Bldg 10,Level 7,235 Jones St, Sydney, NSW 2007, Australia.
EM aharvie@protonmail.com
OI Harvie, Alaia/0000-0002-2951-9004; Wardle, Jonathan/0000-0001-8813-3542;
   Steel, Amie/0000-0001-6643-9444
FU Australian Government Research Training Program (RTP) scholarship
FX This research is supported by an Australian Government Research Training
   Program (RTP) scholarship.
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NR 87
TC 12
Z9 14
U1 1
U2 42
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD AUG 1
PY 2019
VL 25
IS 8
BP 789
EP 808
DI 10.1089/acm.2018.0520
EA JUL 2019
PG 20
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA IR5PA
UT WOS:000474173700001
PM 31274332
DA 2026-01-16
ER

PT J
AU Windmill, J
   Fisher, E
   Eccleston, C
   Derry, S
   Stannard, C
   Knaggs, R
   Moore, RA
AF Windmill, Jude
   Fisher, Emma
   Eccleston, Christopher
   Derry, Sheena
   Stannard, Cathy
   Knaggs, Roger
   Moore, R. Andrew
TI Interventions for the reduction of prescribed opioid use in chronic
   non-cancer pain
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID LOW-BACK-PAIN; TREATMENT OUTCOMES; EXTENDED-RELEASE; ANALGESIC
   MEDICATION; OLDER-ADULTS; DOUBLE-BLIND; EFFICACY; REHABILITATION;
   WITHDRAWAL; MODERATE
AB Background
   Patients with chronic non-cancer pain who are prescribed and are taking opioids can have a history of long term high dose opioid use without effective pain relief. In those without good pain relief, reduction of prescribed opioid dose may be the desired and shared goal of both patient and clinician. Simple unsupervised reduction of opioid use is clinically challenging, and very difficult to achieve and maintain.
   Objectives
   To investigate the effectiveness of different methods designed to achieve reduction or cessation of prescribed opioid use for the management of chronic non-cancer pain.
   Search methods
   We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE from inception to 8th April 2013, as well as bibliographies.
   Selection criteria
   Included studies had to be randomised controlled trials comparing opioid users receiving an intervention with a control group receiving treatment as usual, active control, or placebo. The aim of the study had to include a treatment goal of dose reduction or cessation of opioid medication.
   Data collection and analysis
   We sought data relating to prescribed opioid use, adverse events of opioid reduction, pain, and psychological and physical function.
   Main results
   Two studies provided information on 86 participants. One compared electroacupuncture with sham acupuncture for 20 minutes twice a week for six weeks; there was no difference between treatments. The other followed 11 weeks of cognitive behavioural therapy with either therapeutic interactive voice response through a computer for four months or usual treatment; the active group had a significant reduction in opioid use, while the usual care group had a significant increase.
   Authors' conclusions
   Both included studies were at significant risk of bias because of their small size, together with other important issues, including blinding. Because of this risk and the paucity of relevant studies, no conclusions can be drawn regarding the effectiveness of interventions for opioid withdrawal in chronic non-cancer pain.
C1 [Windmill, Jude; Derry, Sheena; Moore, R. Andrew] Univ Oxford, Oxford OX3 7LE, England.
   [Windmill, Jude; Derry, Sheena; Moore, R. Andrew] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 7LE, England.
   [Fisher, Emma; Eccleston, Christopher] Univ Bath, Ctr Pain Res, Bath BA2 7AY, Avon, England.
   [Stannard, Cathy] Frenchay Hosp, Macmillan Ctr, Pain Clin, Bristol BS16 1LE, Avon, England.
   [Knaggs, Roger] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England.
C3 University of Oxford; University of Oxford; University of Bath;
   University of Nottingham
RP Windmill, J (corresponding author), Univ Oxford, Churchill Hosp, Oxford OX3 7LE, England.
EM jude_windmill@hotmail.com
RI Fisher, Emma/AHC-6849-2022; Eccleston, Christopher/KIC-3638-2024
OI Fisher, Emma/0000-0001-8980-3181; Eccleston,
   Christopher/0000-0003-0698-1543; Knaggs, Roger/0000-0003-1646-8321
FU AstraZeneca; Eli Lilly; Flynn Pharma; Furtura Medical; Grunenthal; GSK;
   Horizon Pharma; Lundbeck; Menarini; MSD; Pfizer; Reckitt Bensckiser;
   Sanofi Aventis; Urgo; Vifor Pharma
FX RAM has consulted for various pharmaceutical companies and has received
   lecture fees from pharmaceutical companies related to analgesics and
   other healthcare interventions, including (in the past five years)
   AstraZeneca, Eli Lilly, Flynn Pharma, Furtura Medical, Grunenthal, GSK,
   Horizon Pharma, Lundbeck, Menarini, MSD, Pfizer, Reckitt Bensckiser,
   Sanofi Aventis, Urgo, and Vifor Pharma.
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NR 45
TC 34
Z9 39
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 9
AR CD010323
DI 10.1002/14651858.CD010323.pub2
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 227QZ
UT WOS:000325129900027
PM 23996347
OA Bronze
DA 2026-01-16
ER

PT J
AU Lee, EJ
   Frazier, SK
AF Lee, Eun Jin
   Frazier, Susan K.
TI The Efficacy of Acupressure for Symptom Management: A Systematic Review
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Review
DE Acupressure; pain; dyspnea; fatigue; nausea; review
ID STAGE RENAL-DISEASE; QUALITY-OF-LIFE; POSTOPERATIVE NAUSEA; P6
   ACUPRESSURE; PREHOSPITAL ANALGESIA; SPINAL-ANESTHESIA; RELIEVE NAUSEA;
   DOUBLE-BLIND; PREGNANCY; THERAPY
AB Context. Acupressure is a noninvasive strategy used to manage various symptoms.
   Objectives. The purpose of this article was to review randomized controlled trials that investigated the efficacy of acupressure for the management of symptoms.
   Methods. A literature search was conducted in the Cumulative Index to Nursing and Allied Health Literature, Medline, and PubMed using the key words acupressure, clinical trial, human, and/or randomized. Randomized clinical trials published between January 1, 2000 and January 31, 2010, which used acupressure as the sole intervention for one group, were included when they were written in English and when there were four or more studies of the efficacy of acupressure for that particular symptom.
   Results. Forty-three studies were included in this review. Investigators in 16 of 23 studies concluded acupressure was effective, primarily for the management of nausea and vomiting in patients during pregnancy and during chemotherapy. Investigators in nine of 10 studies concluded that acupressure was effective for pain in patients with dysmenorrhea, during labor and after trauma. Investigators of four studies concluded that acupressure was effective in the management of dyspnea and investigators in six studies concluded that acupressure was effective in improving fatigue and reducing insomnia in a variety of populations. However, evaluation of the randomized controlled trial reports indicated a significant likelihood of bias.
   Conclusion. Acupressure may be a useful strategy for the management of multiple symptoms in a variety of patient populations, but rigorous trials are needed. Inclusion of acupressure as an intervention may improve patient outcomes. J Pain Symptom Manage 2011;42:589-603. (C) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
C1 [Lee, Eun Jin] Cent Baptist Hosp, Lexington, KY USA.
   [Frazier, Susan K.] Univ Kentucky, Coll Nursing, Lexington, KY USA.
C3 Central Baptist Hospital; University of Kentucky
RP Lee, EJ (corresponding author), Fayetteville State Univ, 1200 Murchison Rd,Nursing Bldg 311, Fayetteville, NC 28301 USA.
EM peace-peace@hanmail.net
RI Lee, Eun Jin/HPC-9460-2023
FU National Institutes of Health's National Institute of Nursing Research
   [1P20NR010679]
FX This work was supported in part by a grant to the University of
   Kentucky, College of Nursing from the National Institutes of Health's
   National Institute of Nursing Research (1P20NR010679). The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Institute of Nursing
   Research or the National Institutes of Health. The authors declare no
   conflicts of interest.
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NR 64
TC 119
Z9 144
U1 0
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD OCT
PY 2011
VL 42
IS 4
BP 589
EP 603
DI 10.1016/j.jpainsymman.2011.01.007
PG 15
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 836VO
UT WOS:000296144300014
PM 21531533
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Hughes, J
   Cummings, M
   Filshie, J
   Kassab, S
   Leng, G
   Mackereth, P
   MacPherson, H
   de Valois, B
   Fisher, P
AF Hughes, John
   Cummings, Mike
   Filshie, Jacqueline
   Kassab, Sosie
   Leng, Graham
   Mackereth, Peter
   MacPherson, Hugh
   de Valois, Beverley
   Fisher, Peter
TI Ensuring model validity in a feasibility study of acupuncture to improve
   quality of life in cancer patients undergoing radiotherapy treatment
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Acupuncture; Model validity; Cancer; Randomised controlled trial;
   Radiotherapy
AB Introduction: A feasibility study of acupuncture for quality of life in cancer patients is planned. The pragmatic randomised controlled trial will aim to assess the feasibility of training radiographers to administer acupuncture to their patients undergoing radiotherapy intended to cure their cancer. The preliminary phase covered in this paper aimed to develop the trial acupuncture intervention and ensure its model validity.
   Methods: A mixed methods approach will be adopted. Systematic review conducted examining the treatments administered in papers reporting acupuncture treatment for cancer patients. Subsequently, one-day workshop held with an acupuncture expert panel. Informed by the systematic review and their clinical expertise the expert panel devised and agreed the trial acupuncture intervention.
   Results: The acupuncture expert panel came to a consensus on the trial acupuncture intervention. Trial radiographers will treat patients for 30 min, with needles inserted for approximately 20 min of this time. The trial will employ a standard treatment protocol for constitutional symptoms (fatigue, hot flushes, mood problems, anxiety, depression, and sleep problems) consisting of non traditional ASAD (anxiety, sickness and dyspnoea) acupoints, LI4, LR3, SP6 and ST36. Additional acupoints can be utilised for nausea/vomiting and pain. Guidelines on safe practice were also agreed.
   Conclusions: Few clinical trials of acupuncture, and complementary medicine interventions generally, document details of the process by which they ensured the model validity of their trial intervention. It is recommended that researchers in acupuncture, and other forms of complementary medicine, adopt appropriate methodological approaches to ensure model validity.
C1 [Hughes, John; Cummings, Mike; Kassab, Sosie; Fisher, Peter] UCLH NHS Trust, Royal London Hosp Integrated Med, Great Ormond St, London WC1N 3HR, England.
   [Filshie, Jacqueline] Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England.
   [Leng, Graham] Hosp Good Shepherd, Gordon Lane, Chester CH2 4DG, Cheshire, England.
   [Mackereth, Peter] Christie Hosp NHS Trust, Wilmslow Rd, Manchester M20 4BX, Lancs, England.
   [MacPherson, Hugh] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [de Valois, Beverley] Mt Vernon Canc Ctr, Lynda Jackson Macmillan Ctr, Northwood HA6 2RN, Middx, England.
C3 University College London Hospitals NHS Foundation Trust; Royal London
   Hospital For Integrated Medicine; University of London; University
   College London; Great Ormond Street Hospital for Children NHS Foundation
   Trust; Royal Marsden NHS Foundation Trust; Christie NHS Foundation
   Trust; Christie Hospital; University of York - UK; Mount Vernon Cancer
   Centre
RP Hughes, J (corresponding author), Royal London Hosp Integrated Med, 60 Great Ormond St, London WC1N 3HR, England.
EM John.Hughes8@nhs.net
RI ; Cummings, Mike/J-7108-2019
OI de Valois, Beverley/0000-0002-0665-1432; Hughes,
   John/0000-0002-4513-2395; Cummings, Mike/0000-0003-2224-8835;
   MacPherson, Hugh/0000-0003-4255-4768
FU UCLH
FX The study was funded by a programme grant from the UCLH Charitable
   Trustees.
CR Boon H, 2007, EVID-BASED COMPL ALT, V4, P279, DOI 10.1093/ecam/nel079
   Bornhoft Gudrun, 2006, BMC Med Res Methodol, V6, P56
   Filshie J, 2001, Acupunct Med, V19, P117
   Filshie Jacqueline, 2006, Acupunct Med, V24, P172
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NR 9
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2018
VL 21
BP 50
EP 52
DI 10.1016/j.eujim.2018.06.010
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GS5UR
UT WOS:000443737400009
DA 2026-01-16
ER

PT J
AU Wei, HN
   Jiang, LP
   Xiong, B
   Zhou, S
   Yu, L
   Huang, YM
   Liu, DG
   Ling, W
   Song, XN
   Zhang, XX
   Zhao, HL
AF Wei, Han-Ning
   Jiang, Li-Ping
   Xiong, Bin
   Zhou, Si
   Yu, Lan
   Huang, Yan-Mei
   Liu, Dao-Guang
   Ling, Wei
   Song, Xin-Nan
   Zhang, Xiao-Xi
   Zhao, Hai-Lu
TI Characteristic patterns of normal meridian acupoint temperature
SO JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
LA English
DT Article
DE acupoint; medical college students; meridian; skin temperature; symmetry
ID RANDOMIZED CONTROLLED-TRIAL; LOW-BACK-PAIN; ACUPUNCTURE; MOXIBUSTION;
   ELECTROACUPUNCTURE; METAANALYSIS; STIMULATION; CARCINOMA; STRENGTH;
   STROKE
AB Background: Body temperature is an important indicator of health and illness. However, a single temperature measurement is not always reliable. Such measurements can be made using meridians, which are energy channels with acupoints being the nodes. To date, there is no published reference of meridian acupoint temperatures applicable to human health, and there is no clear digitalized indicator that could be utilized to evaluate human health by way of meridian acupoints up to now.
   Methods: Our study recruited 100 healthy medical college students for the measurement of acupoint temperature. The temperatures of 135 acupoints of 14 main meridians were measured using infrared thermometers in order to provide a comprehensive body temperature reading of each study participant.
   (R)esults: The degree of the acupoint temperature consistently ranged from 34.88 degrees C to 36.14 degrees C. The gross thermograph was concentric, with high degree readings around the heart and low degree readings originating from the feet. The left and right body sides had significant correlation between the degrees of bilateral same name acupoint temperatures of 12 regular meridians (correlation coefficient, 0.367-0.985; p < 0.0001). There was also a significant correlation between the acupoint temperature for the governor vessel and the conception vessel (correlation coefficient, 0.083; p = 0.006).
   Conclusion: These findings indicate that meridian acupoint temperature is characterized by a consistently narrow range, as well as concentricity and symmetry in body temperature degree readings in college students. Meridian acupoint temperature may be a sensitive and valuable indicator to assist in the accurate evaluation of meridian and general human health, and the significance and changes of acupoint temperature in clinical conditions warrants future exploration. Copyright (C) 2017, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
C1 [Wei, Han-Ning; Jiang, Li-Ping; Xiong, Bin; Zhou, Si; Yu, Lan; Huang, Yan-Mei; Liu, Dao-Guang; Ling, Wei; Song, Xin-Nan; Zhang, Xiao-Xi; Zhao, Hai-Lu] Guilin Med Univ, Fac Basic Med, Guangxi Lab Excellence, Ctr Syst Med, 109,North 2nd Huan Cheng Rd, Guilin 541004, Guangxi, Peoples R China.
C3 Guilin Medical University
RP Zhao, HL (corresponding author), Guilin Med Univ, Fac Basic Med, Guangxi Lab Excellence, Ctr Syst Med, 109,North 2nd Huan Cheng Rd, Guilin 541004, Guangxi, Peoples R China.
EM zhaohailu9@126.com
FU Program for Innovative Research Team of Guilin Medical University
   (PIRTGMU); National Natural Science Foundation of China [81270934]
FX The work was supported by grants from the Program for Innovative
   Research Team of Guilin Medical University (PIRTGMU) and the National
   Natural Science Foundation of China (81270934). The funding bodies had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 42
TC 8
Z9 8
U1 1
U2 30
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1726-4901
EI 1728-7731
J9 J CHIN MED ASSOC
JI J. Chin. Med. Assoc.
PD JUL
PY 2017
VL 80
IS 7
BP 419
EP 426
DI 10.1016/j.jcma.2016.12.007
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FA4XH
UT WOS:000405446500006
PM 28476445
DA 2026-01-16
ER

PT J
AU Chen, L
   Shen, Y
   Liu, SM
   Cao, YY
AF Chen, Liang
   Shen, Yang
   Liu, Shuangmei
   Cao, Yanyan
TI Transcutaneous Electrical Acupoint Stimulation Improved Preoperative
   Blood Pressure in Gynecological Malignant Tumor Patients With
   Hypertension: A Randomized, Controlled Trial
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE malignant tumor; hypertension; preoperative; electrical stimulation;
   acupoint; complementary therapy
ID NERVE-STIMULATION; HIGH-FREQUENCY; ACUPUNCTURE; ELECTROACUPUNCTURE;
   PAIN; ANESTHESIA; RECOVERY; RELEASE; STRESS; MODEL
AB ObjectiveGynecological malignant tumor patients with hypertension, even if blood pressure is well controlled, are prone to hypertension before surgery. We plan to verify the effect of transcutaneous electrical acupoint stimulation (TEAS) on stabilizing blood pressure before operation. MethodsWe enrolled 91 patients and randomly divided them into TEAS group (n=46) and control group (n=45). Patients in TEAS group received TEAS at acupoints Hegu and Neiguan. Patients in control group received transcutaneous electrical stimulation at the nonacupoint position of the upper limbs. After entering the operating room, the blood pressure before and after induction was measured. The main results were the occurrence of preinduction hypertension and postinduction hypotension. ResultsThere was no difference in the general information of the two groups. There were four cases (9%) of preinduction hypertension in TEAS group and 13 cases (29%) in control group. The incidence in TEAS group was significantly lower (P=0.013). There were five cases (11%) of postinduction hypotension in TEAS group and eight cases (18%) in control group. There was no significant difference between the two groups (P=0.346). The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) of the highest blood pressure before induction in TEAS group were lower than those in control group (P=0.002, 0.002, and 0.001). There was no difference in SBP, DBP, or MBP between the two groups on the day before the operation. There was no difference in the lowest blood pressure before operation between the two groups after induction ConclusionTEAS can prevent preinduction hypertension in patients with gynecological malignant tumors.
C1 [Chen, Liang; Liu, Shuangmei; Cao, Yanyan] China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China.
   [Shen, Yang] China Med Univ, Dept Emergency Med, Shengjing Hosp, Shenyang, Peoples R China.
C3 China Medical University; China Medical University
RP Shen, Y (corresponding author), China Med Univ, Dept Emergency Med, Shengjing Hosp, Shenyang, Peoples R China.
EM cmushy@163.com
CR Abdi H, 2017, COMPLEMENT THER MED, V31, P20, DOI 10.1016/j.ctim.2017.01.003
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NR 30
TC 7
Z9 9
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUN 1
PY 2022
VL 12
AR 906528
DI 10.3389/fonc.2022.906528
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2D9WP
UT WOS:000811888200001
PM 35720011
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, TC
   Zhang, JF
   Lv, Y
   Wu, YC
AF Lu, Tianchen
   Zhang, Junfeng
   Lv, Ying
   Wu, Yaochi
TI The effect of warm needle moxibustion on lumbar disc herniation
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Warm needle moxibustion; lumbar disc herniation; therapeutic effect
ID NONOPERATIVE TREATMENT; MANAGEMENT; ACUPUNCTURE; EFFICACY
AB Objective: To investigate the effect of warm needle moxibustion on patients with lumbar disc herniation (LDH). Methods: A total of 100 patients with lumbar disc herniation treated in our hospital were recruited as the study cohort and randomly assigned into a control group and an observation group. The patients in the control group underwent routine acupuncture treatment, while those in the observation group underwent warm needle moxibustion treatment. The observed indexes, including the clinical efficacy, the visual analogue scale (VAS) scores, the Japanese Orthopedic Association (JOA) scores, the Oswestry disability index (ODI) scores, and the serum inflammatory factor levels were compared between the control group and the observation group. Results: The total cure rate in the observation group was significantly higher than it was in the control group (76.0% vs 92%, P=0.029). Compared with the patients in the control group after the treatment, the patients' VAS and ODI scores in the observation group were significantly lower, but their JOA scores were significantly higher, and the differences were statistically significant (all P<0.001). Moreover, the serum IL-6 and tumor necrosis factor alpha (TNF-alpha) levels in the observation group were remarkably lower than the corresponding levels in the control group (all P<0.001). Conclusions: Warm needle moxibustion has a significant effect on patients with lumbar disc herniation, because it helps to relieve the pain and other symptoms and reduces the serum inflammatory factor levels.
C1 [Lu, Tianchen; Zhang, Junfeng; Lv, Ying; Wu, Yaochi] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Acupuncture & Massage, 600 Yishan Rd, Shanghai 200233, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wu, YC (corresponding author), Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Acupuncture & Massage, 600 Yishan Rd, Shanghai 200233, Peoples R China.
EM wuyaochi_tcm@163.com
RI zhang, junfeng/JHT-7871-2023
FU Alliance Construction Project of Shanghai Chinese Medicine Specialty
   (Special disease) [ZY (2018-2020)-FWTX-4020]
FX This research was supported by the Alliance Construction Project of
   Shanghai Chinese Medicine Specialty (Special disease) [No. ZY
   (2018-2020)-FWTX-4020] .
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TC 10
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U1 1
U2 16
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 5
BP 5059
EP 5065
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA SM3BJ
UT WOS:000657484200049
PM 34150092
DA 2026-01-16
ER

PT J
AU Mallory, MJ
   Croghan, KA
   Sandhu, NP
   Lemaine, V
   Degnim, AC
   Bauer, BA
   Cha, SS
   Croghan, IT
AF Mallory, Molly J.
   Croghan, Katrina A.
   Sandhu, Nicole P.
   Lemaine, Valerie
   Degnim, Amy C.
   Bauer, Brent A.
   Cha, Stephen S.
   Croghan, Ivana T.
TI Acupuncture in the Postoperative Setting for Breast Cancer Patients: A
   Feasibility Study
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Acupuncture; Breast Cancer; Breast Reconstruction; Feasibility;
   Mastectomy; Postsurgical; Quality of Life
ID COMPLEMENTARY/ALTERNATIVE MEDICINE; PAIN; ELECTROACUPUNCTURE
AB Acupuncture is used to treat a variety of symptoms and conditions associated with cancer and cancer treatments. The present study was performed to evaluate the feasibility of providing acupuncture in the hospital setting for breast cancer patients and to evaluate the short-term effect of acupuncture on stress, anxiety, and pain. This was an open label study conducted at Mayo Clinic Hospital, Methodist and Saint Marys Campus, Rochester, Minnesota. A total of 20 adult breast cancer patients undergoing mastectomy and/or breast reconstruction were recruited and offered daily acupuncture intervention beginning postoperative day 1 and continuing for the duration of the hospital stay. Outcome measures included the Symptom Visual Analog Scale (VAS) and Satisfaction Question and Was-it-Worth-it (WIWI) Questionnaire. It was found that acupuncture is a feasible option for postoperative breast cancer patients. In addition, it can significantly decrease the levels of anxiety (p = 0.0065), tension/muscular discomfort (p < 0.001) and pain (p = 0.023). The association between acupuncture and relaxation was found to be statistically borderline (p = 0.053). This feasibility study showed that acupuncture can be integrated into a busy postsurgical clinical practice. These results also suggest that acupuncture may be an important intervention in the postoperative setting for breast cancer patients.
C1 [Mallory, Molly J.; Sandhu, Nicole P.; Bauer, Brent A.] Mayo Clin, Dept Med, Rochester, MN 55905 USA.
   [Croghan, Katrina A.] Mayo Clin, Dept Med Res, Rochester, MN 55905 USA.
   [Croghan, Ivana T.] Mayo Clin, Rochester, MN 55905 USA.
   [Lemaine, Valerie; Degnim, Amy C.] Mayo Clin, Dept Surg, Rochester, MN 55905 USA.
   [Cha, Stephen S.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Mallory, MJ (corresponding author), Mayo Clin, Dept Med, 200 First St SW, Rochester, MN 55905 USA.
EM mallory.molly@mayo.edu
RI Mallory, Molly/AAF-7370-2021
FU General Internal Medicine Faculty Development Committee; Career
   Development Award; Mayo Clinic Department of Medicine Clinical Research
   Office; Center for Clinical and Translational Science [UL1 TR000135]
FX This study was supported in part by the General Internal Medicine
   Faculty Development Committee and the Career Development Award. The
   authors are indebted to the support of Mayo Clinic Department of
   Medicine Clinical Research Office and its support team including Bonnie
   Donelan Dunlap. The authors gratefully acknowledge the General Internal
   Medicine Research Committee for granting the time necessary to complete
   the study and to write the manuscript. Dietlind Wahner-Roedler, MD,
   Susanne M. Cutshall, RN, CNS and Lisa Bungum, RN contributed valuable
   discussion and support with study planning and implementation. Finally,
   the data entry program used was REDcap and that in turn had a Center for
   Clinical and Translational Science grant support (UL1 TR000135).
CR American Cancer Society, SURG BREAST CANC 201
   An LX, 2014, AM J CHINESE MED, V42, P1099, DOI 10.1142/S0192415X14500682
   [Anonymous], 2012, Breast cancer risk in American women
   [Anonymous], Breast Cancer Facts and Figures 2009-2010
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NR 20
TC 23
Z9 27
U1 1
U2 27
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2015
VL 43
IS 1
BP 45
EP 56
DI 10.1142/S0192415X15500032
PG 12
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA CB5WS
UT WOS:000349699300003
PM 25682785
DA 2026-01-16
ER

PT J
AU Li, MY
   Wang, T
   Liu, XL
   Deng, RL
   Kwok, WH
   Yao, LQ
   Tan, JY
AF Li, Mengyuan
   Wang, Tao
   Liu, Xian-Liang
   Deng, Ren-Li
   Kwok, Wai Hang
   Yao, Li-Qun
   Tan, Jing-Yu (Benjamin)
TI Somatic acupressure for the management of the fatigue-sleep
   disturbance-depression symptom cluster in breast cancer survivors: a
   study protocol for a phase III randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE Breast tumours; Fatigue; Depression & mood disorders; Insomnia; Nursing
   research
ID TRADITIONAL CHINESE MEDICINE; VERSION; ACUPUNCTURE; PAIN; VALIDATION
AB Introduction The fatigue-sleep disturbance-depression symptom cluster (FSDSC) is commonly experienced by breast cancer (BC) survivors, leading to a deteriorated quality of life (QoL). Somatic acupressure (SA) has been recommended as a promising non-pharmacological intervention for cancer-related fatigue (the core symptom of the FSDSC) in the guidelines, showing its encouraging role in relieving cancer-related sleep disorders, fatigue and depression. This phase III randomised controlled trial (RCT) is designed to evaluate the effects, safety and cost-effectiveness of SA for managing the FSDSC in BC survivors. Methods This phase III RCT will be a partial-blinded, sham-controlled, three-arm, parallel clinical trial, involving a 7-week SA intervention period and a 12-week follow-up period. 108 BC survivors will be randomly allocated in a ratio of 1:1:1 to either a true SA group (self-administered acupressure plus usual care), a sham SA group (self-administered light acupressure at non-acupoints plus usual care) or a usual care group. The primary outcomes will be the effectiveness of SA on the FSDSC at both the individual symptom level and cluster symptom level. Each individual symptom will be specifically measured by the Brief Fatigue Inventory (fatigue), the Pittsburgh Sleep Quality Index (sleep disturbance) and the Hospital Anxiety and Depression Scale-Depression (depression). The cluster symptom level will be measured by using an FSDSC composite score, an averaging score of three separated 0-10 numeric rating scales for fatigue, depression and sleep disturbance. The secondary outcomes will include QoL (measured by the Functional Assessment of Cancer Therapy-Breast), adverse events and cost-effectiveness. Outcomes will be assessed at baseline (week 0), immediately after intervention (week 7) and follow-up (week 19). All outcomes will be analysed based on the intention-to-treat principle using the Statistical Package for Social Science (SPSS 25) software. Ethics and dissemination Ethical approvals of this study have been granted by the Human Research Ethics Committee at Charles Darwin University (H22110) and the Clinical Trial Ethics Committee at the Affiliated Hospital of Zunyi Medical University (KLL-2023-594), and the Second Affiliated Hospital of Zunyi Medical University (KYLL-2023-058). Findings from this trial will be published in peer-reviewed journals and presented at professional conferences. Trial registration number NCT06412107.
C1 [Li, Mengyuan; Wang, Tao] Charles Darwin Univ, Fac Hlth, Brisbane, Qld, Australia.
   [Wang, Tao; Tan, Jing-Yu (Benjamin)] Univ Southern Queensland, Sch Nursing & Midwifery, Ipswich, Qld, Australia.
   [Liu, Xian-Liang] Hong Kong Metropolitan Univ, Sch Nursing & Hlth Sci, Hong Kong, Peoples R China.
   [Deng, Ren-Li] Zunyi Med Univ, Sch Nursing, Zunyi, Guizhou, Peoples R China.
   [Deng, Ren-Li; Kwok, Wai Hang] Charles Darwin Univ, Fac Hlth, Darwin, NT, Australia.
   [Kwok, Wai Hang] Edith Cowan Univ, Sch Nursing & Midwifery, Joondalup, WA, Australia.
   [Yao, Li-Qun] Fujian Univ Tradit Chinese Med, Coll Nursing, Fuzhou, Fujian, Peoples R China.
   [Tan, Jing-Yu (Benjamin)] Univ Southern Queensland, Ctr Hlth Res, Springfield, Qld, Australia.
C3 Charles Darwin University; University of Southern Queensland; Hong Kong
   Metropolitan University; Zunyi Medical University; Charles Darwin
   University; Edith Cowan University; Fujian University of Traditional
   Chinese Medicine; University of Southern Queensland
RP Tan, JY (corresponding author), Univ Southern Queensland, Sch Nursing & Midwifery, Ipswich, Qld, Australia.; Tan, JY (corresponding author), Univ Southern Queensland, Ctr Hlth Res, Springfield, Qld, Australia.
EM mengyuanli@students.cdu.edu.au; alison.wang@cdu.edu.au;
   dxliu@hkmu.edu.hk; rengli.deng@cdu.edu.au; w.kwok@ecu.edu.au;
   yaoliqunpt@163.com; benjamin.tan@unisq.edu.au
RI ; TAN, JINGYU/AAE-5262-2022; Liu, Xian-Liang/JCE-5149-2023
OI Li, Mengyuan/0009-0003-9476-2734; TAN, JINGYU/0000-0002-1609-6890; WANG,
   Tao/0000-0001-9845-3988; Liu, Xian-Liang/0000-0002-3296-5339
FU Charles Darwin International PhD Scholarship (CDIPS), Charles Darwin
   University, Australia
FX This study was supported by Charles Darwin International PhD Scholarship
   (CDIPS), Charles Darwin University, Australia.
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NR 71
TC 0
Z9 0
U1 5
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR 3
PY 2025
VL 15
IS 3
AR e089515
DI 10.1136/bmjopen-2024-089515
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Z2K3I
UT WOS:001437256100001
PM 40032405
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Cheng, HL
   Yeung, WF
   Wong, HF
   Lo, HT
   Molassiotis, A
AF Cheng, Hui-Lin
   Yeung, Wing-Fai
   Wong, Hon-Fat
   Lo, Huen-Ting
   Molassiotis, Alex
TI Self-Acupressure for Symptom Management in Cancer Patients: A Systematic
   Review
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Review
DE Cancer; symptom; acupressure; systematic review; nausea; vomiting
ID CHEMOTHERAPY-INDUCED NAUSEA; ADMINISTERED ACUPRESSURE; FATIGUE;
   ACUPUNCTURE; FIDELITY; THERAPY
AB Context. Acupressure is a popular nonpharmacological intervention that is increasingly proven to effectively alleviate symptoms in patients with cancer. However, the effects of self-acupressure on cancer symptom management are less clear.Objectives. This systematic review is the first to summarize the current experimental evidence on self-acupressure for symptom management in cancer patients.Methods. Eight electronic databases were searched for experimental studies that examined self-acupressure for cancer patients with symptoms and published in peer-reviewed English or Chinese journals. The methodological quality of the included studies was evaluated using the revised Cochrane risk-of-bias assessment tool and the JBI critical appraisal checklist for quasi-experimental studies. Data were extracted as predefined and synthesized narratively. The Template for Intervention Description and Replication checklist was used to report the intervention characteristics.Results. A total of 11 studies were included in this study, six as feasibility or pilot trials. The methodological quality of included studies was suboptimal. Substantial heterogeneity was observed in acupressure training, acupoint selection, intervention duration, dosage, and timing. Self-acupressure was only associated with reduced nausea and vomiting (P = 0.006 and P = 0.001).Conclusion. The limited evidence from this review precludes the definitive conclusions on intervention effectiveness for cancer symptoms. Future research should consider developing the standard protocol for intervention delivery, improving the methodology of self-acupressure trials, and conducting large-scale research to advance the science of self-acupressure for cancer symptom management. J Pain Symptom Manage 2023;66:e109-e128.& COPY; 2023 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Cheng, Hui-Lin; Yeung, Wing-Fai; Wong, Hon-Fat; Lo, Huen-Ting] Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Kowloon, Hong Kong, Peoples R China.
   [Molassiotis, Alex] Univ Derby, Coll Arts Humanities & Educ, Derby, England.
   [Cheng, Hui-Lin] Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Kowloon, FG 511,11 Yuk Choi Rd, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Derby; Hong Kong
   Polytechnic University
RP Cheng, HL (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Kowloon, FG 511,11 Yuk Choi Rd, Hong Kong, Peoples R China.
EM eileen.cheng@polyu.edu.hk
RI Yeung, Wing-Fai/E-7971-2013; Molasiotis, Alex/MDS-6695-2025
FU Departmental General Research Fund at the Hong Kong Polytechnic
   University [P0014025]
FX This research was funded by Departmental General Research Fund
   (P0014025) at the Hong Kong Polytechnic University. The authors declare
   no conflicts of interest.
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   Tang WR, 2014, COMPLEMENT THER MED, V22, P581, DOI 10.1016/j.ctim.2014.05.006
   The Joanna Briggs Institute, JBI CRIT APPR CHECKL
   Tiwari AK, 2017, BIOMECH MODEL MECHAN, V16, P395, DOI 10.1007/s10237-016-0824-z
   WHO Regional Office for the Western Pacific, 2008, WHO STAND AC POINT L
   Wyatt G, 2015, ALTERN THER HEALTH M, V21, P18
   Yeung WF, 2022, PHYTOMEDICINE, V99, DOI 10.1016/j.phymed.2022.153993
   Yeung WF, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/902578
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   Zick SM, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/142913
NR 40
TC 13
Z9 15
U1 2
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JUL
PY 2023
VL 66
IS 1
BP E109
EP E128
DI 10.1016/j.jpainsymman.2023.03.002
EA JUN 2023
PG 20
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA M2HL4
UT WOS:001028442900001
PM 36898639
DA 2026-01-16
ER

PT J
AU Liang, Y
   Du, JY
   Fang, JF
   Fang, RY
   Zhou, J
   Shao, XM
   Jiang, YL
   Chen, YT
   Fang, JQ
AF Liang, Yi
   Du, Jun-Ying
   Fang, Jun-Fan
   Fang, Ruo-Yi
   Zhou, Jie
   Shao, Xiao-Mei
   Jiang, Yong-Liang
   Chen, Yi-Tian
   Fang, Jian-Qiao
TI Alleviating Mechanical Allodynia and Modulating Cellular Immunity
   Contribute to Electroacupuncture's Dual Effect on Bone Cancer Pain
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE bone cancer pain; electroacupuncture; morphine; analgesia; mechanical
   allodynia; cellular immunity; naloxone
ID PERIPHERAL OPIOID RECEPTORS; RAT MODEL; MORPHINE; ACUPUNCTURE;
   EXPRESSION; ANALGESIA; ACTIVATION; CELLS
AB Hypothesis: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear. This study aimed to investigate the effects of EA on mechanical allodynia and cellular immunity of BCP rats, and to further explore the potential mechanism. Methods: The BCP model was established by implanting Walker 256 mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley rats. EA (dilatational wave, 2/100 Hz, 0.5 mA-1mA-1.5 mA for 10 minutes each intensity) was applied bilaterally to Zusanli (ST 36) and Kunlun (BL 60) for 30 minutes. Both EA stimulation and morphine (10 mg/kg, intraperitoneally) was given once every other day. Naloxone (0.3 mg/kg, intraperitoneally) was injected at 30 minutes prior to EA. Mechanical allodynia were demonstrated by paw withdrawal thresholds (PWTs) which measured by dynamic plantar aesthesiometer. T cell proliferation, percentage of CD3(+), CD4(+) and CD8(+) T lymphocytes in spleen as well as expression of interleukin-2 (IL-2) in plasma were detected by WST-8, flow cytometry, and enzyme-linked immunosorbent assay technique, respectively. Results: An intratibial inoculation of Walker 256 mammary gland carcinoma cells significantly decreased PWTs to mechanical stimuli. EA stimulation alleviated mechanical allodynia in BCP rats, and the analgesic potency of EA was weaker than that of morphine. In contrast to morphine, EA stimulation of BCP rats increased splenic concanavalin A (Con A)-induced T cell proliferation and plasma IL-2 content, as well as increased the percentages of splenic CD3+CD4+ and CD3+CD8+ T cell subsets. Moreover, both the analgesic effect and the partial immunomodulation of EA were suppressed by an intraperitoneal injection of naloxone. Conclusion: EA could significantly alleviate BCP-induced mechanical allodynia. Although the analgesic effect of EA was weaker than that of morphine, EA had an immunomodulation effect on cellular immunity. Both analgesic and immunomodulatory effect of EA might share the same mechanism via the opioid-mediated pathway, which needs further investigation.
C1 [Liang, Yi; Du, Jun-Ying; Fang, Jun-Fan; Fang, Ruo-Yi; Shao, Xiao-Mei; Jiang, Yong-Liang; Chen, Yi-Tian; Fang, Jian-Qiao] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Zhejiang, Peoples R China.
   [Liang, Yi; Zhou, Jie] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Fang, JQ (corresponding author), Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
EM fangjianqiao7532@163.com
RI Du, Junying/AEV-3719-2022
OI Fang, Jianqiao/0000-0002-5155-8544
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NR 43
TC 19
Z9 25
U1 1
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2018
VL 17
IS 2
BP 401
EP 410
DI 10.1177/1534735417728335
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA GF6JS
UT WOS:000432073700025
PM 28870114
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, P
   Zhu, L
   Zheng, SY
   Li, JX
   Wu, MD
   Wang, WJ
   Hou, YC
   Li, J
   Wu, HG
AF Wu, Pin
   Zhu, Lu
   Zheng, Shi-Yu
   Li, Jun-Xiong
   Wu, Meng -Die
   Wang, Wen-Jia
   Hou, Yu-Chao
   Li, Jing
   Wu, Huan-Gan
TI Transcutaneous Electrical Acupoint Stimulation for Moderate to Severe
   Pain in Hepatocellular Carcinoma: A Protocol for a Randomized Controlled
   Trial
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE protocol; hepatocellular carcinoma; TEAS; pain
ID CANCER PAIN; ACUPUNCTURE; PREVALENCE; MANAGEMENT
AB Background: Cancer-related pain is one of the primary symptoms of patients with hepatocellular carcinoma (HCC). Previous studies have shown that transcutaneous electrical acupoint stimulation (TEAS) is effective in treating patients with acute or chronic pain. In China, it is indispensable to evaluate the efficacy of TEAS in combination with opioids for the treatment of moderate to severe HCC-related pain.Methods/Design: This is a single-center clinical, prospective randomized controlled clinical trial protocol. 104 patients will be randomly divided into the observation group and the control group in a ratio of 1:1.In addition to routine cancer pain medication, the two groups of patients will receive TEAS treatment twice a day for one week. Acupoints will include bilateral Hegu(LI4), Neiguan (PC6), Zusanli(ST36), Taichong(LR3), Ganshu(BL18), Geshu(BL17), Qimen(LR14), and Zhangmen(LR13). The treatment time is from 9:00 a.m. to 11:00 p.m. and from 4:00 p.m. to 6:00 p.m. The primary outcome measures are the Numerical Rating Scale (NRS) and the secondary outcome measures include the Brief Pain Inventory(BPI), dosage and administration duration of opioid drugs, frequency of nausea, vomiting and defecation, Karnofsky Performance Status Scale (KPS), Quality of life scale (QOL), Brief Fatigue Inventory (BFI). The outcome measures will be evaluated at baseline, during treatment and 1 week after treatment.Discussion: Results of this trial are expected to clarify the value of TEAS stimulation performed on specific points in the management of moderate to severe pain in HCC.Trial registration: Chinese clinical trial registry, ChiCTR2100044615 (http://www.chictr.org.cn), Registered on 24 March 2021.
C1 [Wu, Pin; Zhu, Lu; Zheng, Shi-Yu; Li, Jun-Xiong; Wu, Meng -Die; Wang, Wen-Jia; Hou, Yu-Chao; Li, Jing; Wu, Huan-Gan] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Acupuncture, Shanghai, Peoples R China.
   [Wu, Huan-Gan] Shanghai Univ Tradit Chinese Med, Key Lab Acupuncture & Immunol Effects, Shanghai, Peoples R China.
   [Li, Jing] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Acupuncture, 110 Ganhe Rd, Shanghai 200437, Peoples R China.
   [Wu, Huan-Gan] Shanghai Univ Tradit Chinese Med, Dept Key Lab Acupuncture & Immunol Effects, 650 South Wanping Rd, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine; Shanghai University of Traditional Chinese Medicine
RP Li, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Acupuncture, 110 Ganhe Rd, Shanghai 200437, Peoples R China.; Wu, HG (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Key Lab Acupuncture & Immunol Effects, 650 South Wanping Rd, Shanghai 200437, Peoples R China.
EM 1971921250@qq.com; wuhuangan@126.com
RI ; Zheng, Shiyu/KBD-3842-2024
OI Wang, wenjia/0000-0002-8663-1983; wu, pin/0000-0001-6359-7690; Li,
   Jing/0000-0001-9388-5036
FU Science and Technology Innovation Action Plan [20Y21902800]; Qihuang
   scholar in the National Support Program for Leading Talents of
   Traditional Chinese Medicine
FX This study is supported by Shanghai 2020 "Science and Technology
   Innovation Action Plan" (20Y21902800) ; Qihuang scholar in the National
   Support Program for Leading Talents of Traditional Chinese Medicine.
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NR 34
TC 1
Z9 1
U1 3
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2022
VL 15
DI 10.2147/JPR.S361821
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2Z1VX
UT WOS:000826374700001
PM 35832212
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, ZH
   Wang, Q
   Sun, XD
   Zhang, W
   Min, S
   Zhang, JQ
   Zhao, WX
   Jiang, JF
   Wang, YH
   Zhu, YM
   Zheng, LL
   Wang, Y
   Guo, YY
   Zhang, LY
   Wang, LN
   Lei, C
   Liu, TT
   Yang, X
   Zhang, JB
   Li, C
   Zhang, N
   Dong, HL
   Xiong, LZ
AF Lu, Zhihong
   Wang, Qiang
   Sun, Xude
   Zhang, Wei
   Min, Su
   Zhang, Jiaqiang
   Zhao, Weixian
   Jiang, Jianfeng
   Wang, Yonghui
   Zhu, Yaomin
   Zheng, Lanlan
   Wang, Ying
   Guo, Yuanyuan
   Zhang, Liyuan
   Wang, Lini
   Lei, Chong
   Liu, Tingting
   Yang, Xue
   Zhang, Junbao
   Li, Chen
   Zhang, Nian
   Dong, Hailong
   Xiong, Lize
TI Transcutaneous electrical acupoint stimulation before surgery reduces
   chronic pain after mastectomy: A randomized clinical trial
SO JOURNAL OF CLINICAL ANESTHESIA
LA English
DT Article
DE Postoperative pain; Chronic pain; Mastectomy; Acupoint stimulation;
   Combined acupoints
ID BREAST-CANCER; RECEPTOR ANTAGONISTS; NEUROPATHIC PAIN; PERSISTENT PAIN;
   ACUPUNCTURE; ELECTROACUPUNCTURE; REMIFENTANIL; COMBINATION; CONSUMPTION;
   MECHANISMS
AB Study objective: Despite multiple interventions, the incidence of chronic pain after mastectomy could be as high as 50% after surgery. This study aimed to determine the efficacy of transcutaneous electrical acupoint stimulation (TEAS) before anesthesia induction in reducing chronic pain and to compare the effect of combined acupoint TEAS with that of single acupoint TEAS. Design: A multicenter randomized clinical trial. Setting: The study was conducted at six medical centers in China from May 2016 to April 2018. Final follow-up was on October 26, 2018. Participants: Eligible patients were women scheduled for radical mastectomy under general anesthesia. Interventions: Patients were randomly and equally grouped into sham control (n = 188), single acupoint (PC6, n = 198), or combined acupoints (PC6 and CV17, n = 190) TEAS groups using a centralized computer-generated randomization system. TEAS was applied for 30 min before anesthesia induction. The sham-operated control group received electrode attachment but without stimulation. Anesthesiologists, surgeons, and outcome assessors were blinded to the interventions. Measures: The primary endpoint was the incidence of chronic pain 6 months after surgery. Incidences were compared among the groups using the unadjusted chi 2 test. Results: Of the 576 randomized patients, 568 completed the trial. In the intention-to-treat analysis, postmastectomy pain at 6 months was reported in 42 of 190 patients (22.1%) in the combined acupoints group, 65 of 188 patients (34.6%) in the sham-operated group (P = 0.007; relative risk [RR], 95% confidence interval [CI]: 0.68, 0.52-0.89), and 72 of 198 patients (36.4%) in the single acupoint group (P = 0.002; RR, 95% CI: 0.72,0.55-0.93). Remifentanil consumption during surgery and postoperative nausea and vomiting at 24 h after surgery were lower in the combined acupoint group than that in the sham-operated group. Conclusion: TEAS at combined acupoints before surgery was associated with reduced chronic pain 6 months after surgery. Trial registration: Clinicaltrials.gov identifier: NCT02741726. Registered on April 13, 2016.
C1 [Lu, Zhihong; Jiang, Jianfeng; Wang, Yonghui; Wang, Lini; Lei, Chong; Liu, Tingting; Yang, Xue; Zhang, Junbao; Dong, Hailong; Xiong, Lize] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Changle West Rd 127, Xian 710032, Shaanxi, Peoples R China.
   [Wang, Qiang; Zhu, Yaomin] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, Xian 710061, Shaanxi, Peoples R China.
   [Sun, Xude; Zhang, Nian] Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Shaanxi, Peoples R China.
   [Zhang, Wei] Zhengzhou Univ, Affiliated Hosp 1, Dept Anesthesiol, Zhengzhou 450052, Henan, Peoples R China.
   [Min, Su] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing 400016, Peoples R China.
   [Zhang, Jiaqiang] Zhengzhou Univ, Dept Anesthesiol & Perioperat Med, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China.
   [Zhao, Weixian] Guangdong Univ Tradit Chinese Med, Dept Anesthesiol, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China.
   [Li, Chen] Fourth Mil Med Univ, Dept Med Stat, Xian 710032, Shaanxi, Peoples R China.
   [Xiong, Lize] Tongji Univ, Translat Res Inst Brain & Brain Intelligence, Dept Anesthesiol & Perioperat Med, Shanghai Peoples Hosp 4,Sch Med, Shanghai 200434, Peoples R China.
C3 Air Force Medical University; Xi'an Jiaotong University; Air Force
   Medical University; Zhengzhou University; Chongqing Medical University;
   Zhengzhou University; Guangzhou University of Chinese Medicine; Air
   Force Medical University; Tongji University
RP Lu, ZH (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Changle West Rd 127, Xian 710032, Shaanxi, Peoples R China.; Xiong, LZ (corresponding author), Tongji Univ, Translat Res Inst Brain & Brain Intelligence, Dept Anesthesiol & Perioperat Med, Shanghai Peoples Hosp 4,Sch Med, Sanmen Rd 1279, Shanghai 200434, Peoples R China.
EM deerlu23@163.com; lizexiong@tongji.edu.cn
OI Dong, Hailong/0000-0001-8984-9067; lu, zhihong/0000-0001-5639-4705
FU National Key Basic Research Pro-gram of China [2014CB543200]; Overseas,
   Hong Kong & Macao Scholars Collaborative Researching Fund [81228022];
   Major Program of National Natural Science Foundation of China
   [81590954]; National Natural Science Foundation of China [81730032,
   81871028]; Natural Science Foundation of Shaanxi Province [2018SF-277]
FX This work was supported by the National Key Basic Research Pro-gram of
   China (No. 2014CB543200) , the Overseas, Hong Kong & Macao Scholars
   Collaborative Researching Fund (No. 81228022) , Major Program of
   National Natural Science Foundation of China (No. 81590954) , the
   National Natural Science Foundation of China (No. 81730032, 81871028)
   and the Natural Science Foundation of Shaanxi Province (No. 2018SF-277)
   .
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NR 39
TC 44
Z9 56
U1 3
U2 59
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0952-8180
EI 1873-4529
J9 J CLIN ANESTH
JI J. Clin. Anesth.
PD NOV
PY 2021
VL 74
AR 110453
DI 10.1016/j.jclinane.2021.110453
EA JUL 2021
PG 7
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA WC6DV
UT WOS:000704347600023
PM 34271271
OA hybrid
DA 2026-01-16
ER

PT J
AU Haumann, J
   Geurts, JW
   van Kuijk, SMJ
   Kremer, B
   Joosten, EA
   van den Beuken-van Everdingen, MHJ
AF Haumann, J.
   Geurts, J. W.
   van Kuijk, S. M. J.
   Kremer, B.
   Joosten, E. A.
   van den Beuken-van Everdingen, M. H. J.
TI Methadone is superior to fentanyl in treating neuropathic pain in
   patients with head-and-neck cancer
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Article
DE Methadone; Fentanyl; Head-and-neck cancer; Cancer pain; NMDA receptor
   antagonist
ID CLINICAL IMPORTANCE; HOSPITAL ANXIETY; ORAL METHADONE; MORPHINE;
   VALIDATION; VERSION; ANTAGONISTS; ROTATION; KETAMINE; RECEPTOR
AB Background: Cancer pain is still inadequately treated in up to 60% of cancer patients. Based on the additional effect on the N-Methyl-D-Aspartate receptor, we expected that methadone (Met) could provide better pain relief than fentanyl (Fen) in cancer pain with a neuropathic pain component.
   Methods: A randomised controlled trial was performed with 52 strong opioids naive patients with head-and-neck cancer with substantial pain (pain Numerical Rating Scale [NRS] > 4) and a neuropathic pain component (Douleur Neuropathique [DN4] > 4). Twenty-six patients were treated with Met and 26 with Fen. Patients were evaluated at 1, 3 and 5 weeks. The primary outcomes were reduction in average pain, clinical success (defined as 50% average pain decrease) and reduction in pain interference. Secondary outcomes were global perceived effect (GPE) and side-effects.
   Findings: Reduction in NRS was higher with the use of Met at 1, 3 and 5 weeks (pain change 2.9, 3.1 and 3.1) compared to Fen (1.4, 1.7 and 2.0). This difference was significant at 1 (p = 0.011) and at 3 weeks (p = 0.03). Clinical success (> 50% improvement) was higher with Met at 1 week (15% versus 50%, p = 0.012). The change in pain interference, the GPE and side-effect profile were not significantly different between the groups.
   Interpretation: This is the first study to compare the effects of Met to Fen in cancer patients with a neuropathic pain component. Based on the results of this study, Met should be considered in the treatment of oncological pain with a neuropathic component. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Haumann, J.; Geurts, J. W.; Joosten, E. A.; van den Beuken-van Everdingen, M. H. J.] Maastricht Univ, Med Ctr, Univ Pain Ctr Maastricht UPCM, Dept Anesthesiol & Pain Management, Maastricht, Netherlands.
   [Haumann, J.] OLVG, Dept Anaesthesiol & Pain Management, Amsterdam, Netherlands.
   [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands.
   [Kremer, B.] Maastricht Univ, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.
   [Joosten, E. A.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Translat Neurosci, Maastricht, Netherlands.
   [van den Beuken-van Everdingen, M. H. J.] Maastricht Univ, Med Ctr MUMC, Ctr Expertise Palliat Care, Maastricht, Netherlands.
C3 Maastricht University; Onze Lieve Vrouwe Gasthuis Hospital; Maastricht
   University; Maastricht University; Maastricht University; Maastricht
   University; Maastricht University Medical Centre (MUMC)
RP van den Beuken-van Everdingen, MHJ (corresponding author), MUMC, RVE Patient Zorg, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM m.vanden.beuken@mumc.nl
RI Geurts, José/P-7822-2019; van Kuijk, Sander/AAH-3239-2021
OI Geurts, José/0000-0002-7043-968X; van den Beuken-van Everdingen,
   Marieke/0000-0002-2446-2862; van Kuijk, Sander/0000-0003-2796-729X
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NR 46
TC 63
Z9 65
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-8049
EI 1879-0852
J9 EUR J CANCER
JI Eur. J. Cancer
PD SEP
PY 2016
VL 65
BP 121
EP 129
DI 10.1016/j.ejca.2016.06.025
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DU5BP
UT WOS:000382227300014
PM 27494037
DA 2026-01-16
ER

PT J
AU Gatti, A
   Gentili, M
   Baciarello, M
   Lazzari, M
   Marzi, R
   Palombo, E
   Sabato, AF
   Fanelli, G
AF Gatti, Antonio
   Gentili, Marta
   Baciarello, Marco
   Lazzari, Marzia
   Marzi, Rossella
   Palombo, Elisa
   Sabato, Alessandro F.
   Fanelli, Guido
TI Breakthrough pain in patients with controlled or uncontrolled pain: An
   observational study
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Article
DE BTP; Oncological pain; Pain treatment
ID CANCER-PAIN; PREVALENCE; RECOMMENDATIONS; ASSOCIATION; DEFINITION;
   OPIOIDS; CARE
AB Background: Breakthrough pain (BTP) is traditionally defined as a pain exacerbation in patients with chronic controlled pain. However, this definition has recently been challenged.
   Objectives: To evaluate the prevalence of unsatisfactory control in patients with chronic cancer pain, and investigate the frequency and intensity of BTP episodes.
   Methods: A total of 665 patients with chronic cancer pain attending 21 pain therapy units in Italy were evaluated for baseline pain intensity and number of BTP episodes over a 30-day period. All patients started, continued or modified treatment for BTP at enrollment, according to medical judgment.
   Results: The number of BTP events was higher in patients with uncontrolled baseline pain, although the intensity and duration of episodes were similar. In patients with uncontrolled baseline pain, the number of events decreased with time and reached values comparable with those reported in patients with controlled pain. Both the intensity of the pain and the duration of the BTP events exhibited similar values in the two groups at all time points, following increased monitoring and the prescription of analgesic medication.
   Conclusion: Patients with uncontrolled baseline pain experienced BTP flares with higher frequency, but similar intensity and duration with respect to patients with controlled pain at baseline. Notably, a close follow-up and adequate management of the BTP episodes led to an improvement of BTP in the observed patients.
C1 [Gatti, Antonio; Lazzari, Marzia; Palombo, Elisa; Sabato, Alessandro F.] Univ Roma Tor Vergata, Tor Vergata Polyclin, Pain Med & Anesthesiol Dept, Rome, Italy.
   [Gentili, Marta] Patient Assoc Vivere Senza Dolore, I-20154 Milan, Italy.
   [Baciarello, Marco; Fanelli, Guido] Univ Parma, Dept Surg Sci, Crit Care & Pain Med Unit, I-43100 Parma, Italy.
   [Marzi, Rossella] Maggiore della Carita Hosp, Pain Therapy Dept, Novara, Italy.
C3 University of Rome Tor Vergata; University of Parma
RP Gentili, M (corresponding author), Patient Assoc Vivere Senza Dolore, Piazza EL Morselli 1, I-20154 Milan, Italy.
EM presidenza@viveresenzadolore.it
RI Baciarello, Marco/B-5492-2008
OI Baciarello, Marco/0000-0002-6939-9764; Fanelli,
   Guido/0000-0002-2991-3378
CR Abernethy Amy P, 2008, Am J Manag Care, V14, pS129
   Burton B, 2011, BR J NURS, V20, pS6
   Burton Beth, 2011, Br J Nurs, V20, pS16
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NR 28
TC 7
Z9 9
U1 0
U2 5
PU PULSUS GROUP INC
PI OAKVILLE
PA 2902 S SHERIDAN WAY, OAKVILLE, ONTARIO L6J 7L6, CANADA
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PD NOV-DEC
PY 2014
VL 19
IS 6
BP E168
EP E171
DI 10.1155/2014/646312
PG 4
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AW0TR
UT WOS:000346007000004
PM 24945289
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Galil, G
   Samuels, N
   Segev, Y
   Schmidt, M
   Gressel, O
AF Ben-Arye, Eran
   Galil, Galit
   Samuels, Noah
   Segev, Yakir
   Schmidt, Meirav
   Gressel, Orit
TI Fine-tuning the needle: analysis of acupuncturist response to
   alarming events during gynecological oncology surgery
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Integrative oncology; Gynecological oncology; Acupuncture; Pain;
   Intraoperative; Integrative medicine
ID STIMULATION
AB Objective Examining an intra-operative acupuncture/acupressure setting, with real-time "fine-tuning" in response to alarming events (AEvs) during gynecological oncology surgery. Methods Narratives of acupuncturists providing intraoperative acupuncture during gynecological oncology surgery were qualitatively analyzed. These described real time "fine-tuning" in response to AEvs during surgery, identified through hemodynamic changes (e.g., systolic/diastolic arterial pressure); bispectral index (BIS) elevation; and feedback from surgeons and anesthesiologists. Documentation of acupuncturist responses to AEvs was addressed as well. Results Of the 48 patients in the cohort, 33 had at least one intraoperative AEv (69%), of which 30 were undergoing laparoscopic surgery and 18 laparotomies. A total of 77 AEvs were documented throughout surgery (range 1-7; mean: 2.3 events per patient), identified through increased (63 events) or decreased (8) mean arterial pressure (MAP); increased BIS levels (2), or other hemodynamic parameters (4). Integrative oncology interventions implemented in response to AEs included acupressure alone (59); combining acupressure with acupuncture (10); or acupuncture alone (4). In 54 (70%) events, documentation was provided from beginning to conclusion of the AEv, with a mean duration of 9.7 min, with 32 events including a documented anesthesiologist intervention. Conclusion The present study demonstrated the feasibility of intraoperative acupuncture with acupressure, with ongoing "fine-tuning" to AEvs identified through objective pain-related parameters (MAP, heart rate and BIS) and real-time input from surgeons and anesthesiologists. Documentation of the intraoperative IO practitioner's response to these AEvs is important, and should be addressed in future research of the innovative integrative model of care.Trial registration number: CMC-18-0037 (Carmel Medical Center, June 11, 2018)
C1 [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Integrat Oncol Program, Oncol Serv, Lin Med Ctr, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Zebulun Med Ctr, Integrat Oncol Program, Oncol Serv, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Carmel Med Ctr, Integrat Oncol Program, Oncol Serv, 35 Rothschild St, Haifa, Israel.
   [Ben-Arye, Eran; Segev, Yakir; Gressel, Orit] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Samuels, Noah] Hebrew Univ Jerusalem, Fac Med, Ctr Integrat Complementary Med, Shaarei Zedek Med Ctr, Jerusalem, Israel.
   [Segev, Yakir; Schmidt, Meirav] Carmel Hosp, Dept Obstet & Gynecol, Unit Gynecol Oncol, Haifa, Israel.
C3 Clalit Health Services; Clalit Health Services; Clalit Health Services;
   Carmel Medical Center; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; Hebrew University of Jerusalem; Shaare
   Zedek Medical Center; Clalit Health Services; Carmel Medical Center
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Integrat Oncol Program, Oncol Serv, Lin Med Ctr, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Zebulun Med Ctr, Integrat Oncol Program, Oncol Serv, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Clalit Hlth Serv, Carmel Med Ctr, Integrat Oncol Program, Oncol Serv, 35 Rothschild St, Haifa, Israel.; Ben-Arye, E (corresponding author), Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
EM eranben@netvision.net.il
FU Israel Cancer Association [20180006]
FX This Research was funded by the Israel Cancer Association (grant number
   20180006).
CR Baldawi M, 2022, J INTEGR COMPLEMENT, V28, P683, DOI 10.1089/jicm.2021.0429
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NR 10
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUN
PY 2024
VL 32
IS 6
AR 343
DI 10.1007/s00520-024-08552-w
PG 7
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA QN9T9
UT WOS:001221677400001
PM 38739310
DA 2026-01-16
ER

PT J
AU Miller, KR
   Patel, JN
   Symanowski, JT
   Edelen, CA
   Walsh, D
AF Miller, Katherine R.
   Patel, Jai N.
   Symanowski, James T.
   Edelen, Connie A.
   Walsh, Declan
TI Acupuncture for Cancer Pain and Symptom Management in a Palliative
   Medicine Clinic
SO AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
LA English
DT Article
DE acupuncture; cancer; pain; palliative; symptom; supportive care
ID FATIGUE; TRIAL
AB Objective: Studies suggest acupuncture improves cancer-related symptoms; however, it is unclear whether patient characteristics predict pain response. This study determined acupuncture's effect on cancer-related pain and identified variables associated with pain response. Methods: A retrospective chart review included adult patients with cancer referred to palliative medicine and received acupuncture for pain management. Paired t tests compared differences in pain scores from pre- to postacupuncture. Clinically meaningful pain improvement was defined as >= 2-point reduction in pain score. Logistic regression was used to evaluate associations between patient characteristics and pain improvement. Results: One hundred seventy acupuncture treatments from 68 individual patients were studied. Significant reductions in mean pain scores were observed after the first treatment (-1.9 +/- 1.8; P < .001) and across all treatments (-1.7 +/- 1.9; P < .001). Multivariable analysis demonstrated clinically meaningful pain improvement with higher baseline pain scores (odds ratio [OR]: 1.79, 95% confidence interval [CI]: 1.44-2.22; P < .001) and stage III/IV disease (OR: 3.23, 95% CI: 1.11-9.40; P < .001). There were significant improvements in anxiety, depression, drowsiness, dyspnea, fatigue, nausea, and well-being after the first treatment and across all treatments (P < .001). Conclusions: Acupuncture improved cancer-related pain and other symptoms. Those with higher baseline pain scores and advanced disease were more likely to achieve significant pain reduction. Improved depression and fatigue were closely related to pain reduction. Further studies are needed to confirm pain response variables, establish durability, and develop a personalized approach to acupuncture.
C1 [Miller, Katherine R.; Patel, Jai N.] Atrium Hlth, Levine Canc Inst, Dept Canc Pharmacol, 1021 Morehead Med Dr,Suite 3100, Charlotte, NC 28204 USA.
   [Patel, Jai N.; Edelen, Connie A.; Walsh, Declan] Atrium Hlth, Dept Support Oncol, Sect Palliat Med, Charlotte, NC USA.
   [Symanowski, James T.] Atrium Hlth, Levine Canc Inst, Dept Biostat, Charlotte, NC USA.
RP Patel, JN (corresponding author), Atrium Hlth, Levine Canc Inst, Dept Canc Pharmacol, 1021 Morehead Med Dr,Suite 3100, Charlotte, NC 28204 USA.
EM jai.patel@atriumhealth.org
RI Patel, Jai/IQT-8937-2023
OI Patel, Jai/0000-0001-9845-3697
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NR 27
TC 35
Z9 42
U1 0
U2 43
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1049-9091
EI 1938-2715
J9 AM J HOSP PALLIAT ME
JI Am. J. Hosp. Palliat. Med.
PD APR
PY 2019
VL 36
IS 4
BP 326
EP 332
DI 10.1177/1049909118804464
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA HM5KN
UT WOS:000459514700009
PM 30286611
DA 2026-01-16
ER

PT J
AU Capodice, JL
AF Capodice, Jillian L.
TI Acupuncture in the Oncology Setting: Clinical Trial Update
SO CURRENT TREATMENT OPTIONS IN ONCOLOGY
LA English
DT Article
ID PALLIATIVE MEDICINE; UK ASSOCIATION; ROYAL-COLLEGE; CANCER PAIN;
   THERAPY; PERSPECTIVE; MANAGEMENT; SYMPTOMS
AB Acupuncture, the insertion of sterile needles into acupuncture points of traditional meridians on the body, is a common and effective treatment for a number of supportive care issues in oncology including acute chemotherapy-induced nausea and vomiting. In the Integrative Oncology setting, acupuncture and Traditional Oriental Medicine have become more visible and many oncology clinics, academic health centers and comprehensive cancer centers recommend and administer acupuncture treatment. Continued basic studies on the physiologic mechanisms of acupuncture and recent clinical trials of acupuncture for cancer patients are enhancing our knowledge and informing our guidelines. While debates on methodological problems confronting the study of acupuncture remain, the most recent research demonstrates that acupuncture is safe, tolerable and effective for a range of side effects resulting from conventional cancer treatments.
C1 Columbia Univ Coll Phys & Surg, Dept Urol, New York, NY 10032 USA.
C3 Columbia University
RP Capodice, JL (corresponding author), Columbia Univ Coll Phys & Surg, Dept Urol, 161 Ft Washington Ave,11th Floor, New York, NY 10032 USA.
EM jc2346@columbia.edu
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NR 31
TC 4
Z9 8
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1527-2729
EI 1534-6277
J9 CURR TREAT OPTION ON
JI Curr. Treat. Options Oncol.
PD DEC
PY 2010
VL 11
IS 3-4
BP 87
EP 94
DI 10.1007/s11864-010-0131-3
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 691SJ
UT WOS:000285100800006
PM 21116744
DA 2026-01-16
ER

PT J
AU Running, A
   Seright, T
AF Running, Alice
   Seright, Teresa
TI Integrative Oncology: Managing Cancer Pain with Complementary and
   Alternative Therapies
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Complementary therapies; Alternative therapies; Cancer; Pain;
   Acupuncture; Bio-Energy; Massage; Music therapy; Evidence
ID ACUPUNCTURE; MANAGEMENT
AB For the projected 1,638,910 patients with a diagnosis of cancer this year, the great majority of them (75-90 %) will experience cancer-related pain. A growing number of these patients will turn to complementary and alternative therapies to assist with the management of their pain and other cancer-related symptoms. The World Health Organization's suggested approach to pain management begins with the use of time honored opioids, but recommends the use of adjuvant therapies early in the management process. Complementary and alternative therapies are being used by more patients each year to assist with the management of their pain. Practitioners and researchers must be aware of the evidence that exists to support or refute the use of these therapies. In this manuscript we review evidence from the recent past on complementary and alternative therapies for pain with emphasis on more common modalities including acupuncture, bio-energy, massage, and music.
C1 [Running, Alice; Seright, Teresa] Montana State Univ, Coll Nursing, Bozeman, MT 59717 USA.
C3 Montana State University System; Montana State University Bozeman
RP Running, A (corresponding author), Montana State Univ, Coll Nursing, POB 17350, Bozeman, MT 59717 USA.
EM alice.running@montana.edu
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NR 35
TC 30
Z9 36
U1 0
U2 49
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD AUG
PY 2012
VL 16
IS 4
BP 325
EP 331
DI 10.1007/s11916-012-0275-x
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 973DP
UT WOS:000306335200007
PM 22639181
DA 2026-01-16
ER

PT J
AU Yeh, ML
   Liao, RW
   Yeh, PH
   Lin, CJ
   Wang, YJ
AF Yeh, Mei-Ling
   Liao, Ru-Wen
   Yeh, Pin-Hsuan
   Lin, Chuan-Ju
   Wang, Yu-Jen
TI Acupuncture-related interventions improve chemotherapy-induced
   peripheral neuropathy: A systematic review and network meta-analysis
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Acupuncture; Chemotherapy-induced peripheral neuropathy; Electrical
   stimulation; Moxibustion; Pain; Quality of life
ID TRANSCUTANEOUS NERVE-STIMULATION; COMPLEMENTARY
AB BackgroundThe previous effects of acupuncture-related interventions in improving chemotherapy-induced peripheral neuropathy (CIPN) symptoms and quality of life (QoL) remain unclear in terms of pairwise comparisons.AimsThis systematic review and network meta-analysis aimed to determine the hierarchical effects of acupuncture-related interventions on symptoms, pain, and QoL associated with CIPN in cancer patients undergoing chemotherapy.MethodsNine electronic databases were searched, including PubMed, Embase, Cochrane Library, EBSCO, Medline Ovid, Airiti Library, China National Knowledge Infrastructure (CNKI), China Journal full-text database (CJFD), and Wanfang. Medical subject heading terms and text words were used to search for eligible randomized controlled trials published from database inception to May 2023.ResultsA total of 33 studies involving 2,027 participants were included. Pairwise meta-analysis revealed that acupuncture-related interventions were superior to usual care, medication, or dietary supplements in improving CIPN symptoms, CIPN pain, and QoL. Furthermore, network meta-analysis indicated that acupuncture plus electrical stimulation (acupuncture-E) had the greatest overall effect among the various interventions. The surface under the cumulative ranking curve (SUCRA) revealed that acupuncture-E ranked the highest in improving CINP symptoms. Acupuncture alone was most effective in reducing CIPN pain, and acupuncture plus moxibustion (acupuncture-M) ranked highest in enhancing QoL.ConclusionThis finding suggests that acupuncture-related interventions can provide patients with benefits in improving CIPN symptoms, pain, and QoL. In particular, acupuncture-E could be the most effective approach in which the provided evidence offers diverse options for cancer patients and healthcare professionals.Implication for the profession and/or patient careThese findings provide valuable insights into the potential benefits of acupuncture-related interventions for managing symptoms, pain, and QoL associated with CIPN in patients undergoing chemotherapy. Among the various interventions studied, overall, acupuncture-E had the most significant impact and was effective for a minimum duration of 3 weeks. On the other hand, transcutaneous electrical acupoint/nerve stimulation (TEAS) was identified as a noninvasive and feasible alternative for patients who had concerns about needles or the risk of bleeding. It is recommended that TEAS interventions should be carried out for a longer period, preferably lasting 4 weeks, to achieve optimal outcomes.Trial registrationThe study protocol was registered in the International Prospective Register of Systematic Reviews. Registration Number: CRD42022319871.
C1 [Yeh, Mei-Ling; Yeh, Pin-Hsuan] Natl Taipei Univ Nursing & Hlth Sci, Dept Nursing, 365 Ming De Rd, Taipei City 11219, Taiwan.
   [Liao, Ru-Wen] Taipei Tzu Chi Hosp, Dept Nursing, 289 Jianguo Rd, New Taipei City 23142, Taiwan.
   [Lin, Chuan-Ju] Hsinchu Cathay Gen Hosp, Dept Nursing, 678 Sec 2 Zhonghua Rd, Hsinchu 300003, Taiwan.
   [Wang, Yu-Jen] Chang Gung Univ Sci & Technol, Dept Nursing, 261 Wenhwa 1 Rd, Taoyuan City 333324, Taiwan.
C3 National Taipei University of Nursing & Health Science (NTUNHS);
   Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital; Cathay
   General Hospital; Chang Gung University of Science & Technology
RP Lin, CJ (corresponding author), Hsinchu Cathay Gen Hosp, Dept Nursing, 678 Sec 2 Zhonghua Rd, Hsinchu 300003, Taiwan.; Wang, YJ (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, 261 Wenhwa 1 Rd, Taoyuan City 333324, Taiwan.
EM cgh306214@cgh.org.tw; yjwang@mail.cgust.edu.tw
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NR 76
TC 12
Z9 13
U1 6
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD AUG 19
PY 2024
VL 24
IS 1
AR 310
DI 10.1186/s12906-024-04603-1
PG 17
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA D1C9E
UT WOS:001293645400001
PM 39160496
OA Green Published, gold
DA 2026-01-16
ER

PT J
AU Enblom, A
   Tomasson, A
   Hammar, M
   Steineck, G
   Börjeson, S
AF Enblom, Anna
   Tomasson, Annica
   Hammar, Mats
   Steineck, Gunnar
   Borjeson, Sussanne
TI Pilot testing of methods for evaluation of acupuncture for emesis during
   radiotherapy: a randomised single subject experimental design
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID QUALITY-OF-LIFE; INDUCED NAUSEA; FUNCTIONAL ASSESSMENT;
   CANCER-CHEMOTHERAPY; PLACEBO NEEDLE; COMPLEMENTARY; PROPHYLAXIS;
   ELECTROACUPUNCTURE; REHABILITATION; ACUPRESSURE
AB Background Many acupuncture studies are of weak methodological quality, possibly due to lack of pilot testing. This pilot study tested design features, including test of feasibility, compliance to treatment and data collection, level of blinding success and the patients' potential perceived effects of the treatment, in preparation for an efficacy study.
   Method A modified single subject experimental design was conducted. 10 cancer patients were randomised to verum penetrating acupuncture or non-penetrating sham needles for 30 min 2-3 times/week during radiotherapy over abdomen/pelvis. They answered test-retested emesis questions (r=0.527-1.0) covering nausea, vomiting, use of antiemetics, wellbeing and activities of daily living.
   Results Overall, the patients completed 98% of the 345 emesis-questionnaire days and 101 of the 115 offered treatments. All patients believed they received verum acupuncture. 10 patients experienced antiemetic effects, seven relaxation, five pain-reduction and five experienced sleep improvement. Two types of nausea questions showed absolute concordance (r=1.0) (n of observations=456). Nausea was experienced by one of five verum acupuncture treated patients (duration median 0% of the radiotherapy-days) and four of five sham acupuncture treated patients (duration median 24% of the radiotherapy-days). Patients experiencing nausea rated decreased wellbeing and performance of daily activities compared to patients free from nausea.
   Conclusions All patients were blinded, complied with verum/sham treatments and data-collection, and believed they had effects of the received treatment. The methods for verum/sham treatment and data collection may thus be used in an adequately powered randomised controlled study of the effect of acupuncture for radiotherapy-induced emesis.
C1 [Enblom, Anna; Borjeson, Sussanne] Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden.
   [Tomasson, Annica] Cty Council Ostergotland, Linkoping, Sweden.
   [Hammar, Mats] Linkoping Univ, Dept Clin & Expt Med, Div Obstet & Gynecol, Linkoping, Sweden.
   [Steineck, Gunnar] Karolinska Inst, Dept Oncol, Div Clin Canc Epidemiol, Stockholm, Sweden.
   [Steineck, Gunnar] Sahlgrens Acad, Dept Oncol, Div Clin Canc Epidemiol, Gothenburg, Sweden.
   [Borjeson, Sussanne] Linkoping Univ Hosp, Ctr Surg & Oncol, Dept Oncol, S-58185 Linkoping, Sweden.
C3 Linkoping University; City Council Ostergotland; Linkoping University;
   Karolinska Institutet; University of Gothenburg; Linkoping University
RP Enblom, A (corresponding author), IMH Omvardnad, C-O S Borjeson BSP Plan 12, SE-58185 Linkoping, Sweden.
EM anna.enblom@ki.se
RI ; Steineck, Gunnar/W-1515-2019; Hammar, Mats/R-7908-2019
OI Börjeson, Sussanne/0000-0002-9786-7326; Steineck,
   Gunnar/0000-0002-0787-3969; 
FU Vardal Foundation-for Health Care Sciences and Allergy Research; Vardal
   Institute; County Council of Ostergotland; University of Linkoping
FX This study was supported by The Vardal Foundation-for Health Care
   Sciences and Allergy Research, The Vardal Institute, The County Council
   of Ostergotland and The University of Linkoping.
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NR 48
TC 14
Z9 15
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD JUN
PY 2011
VL 29
IS 2
BP 94
EP 102
DI 10.1136/aim.2010.003384
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 769KE
UT WOS:000291010600004
PM 21460396
DA 2026-01-16
ER

PT J
AU Shin, S
   Jang, BH
   Park, SH
   Lee, JW
   Chae, MS
   Kim, N
   Suh, HS
   Han, S
   Min, SY
   Baek, SK
   Lim, YJ
   Hwang, DS
AF Shin, Seungwon
   Jang, Bo-Hyoung
   Park, Seung-Hyeok
   Lee, Jin-Wook
   Chae, Min Soo
   Kim, Namhoon
   Suh, Hae Sun
   Han, Sola
   Min, Sun Young
   Baek, Sun Kyung
   Lim, Yu Jin
   Hwang, Deok-Sang
TI Effectiveness, safety, and economic evaluation of adjuvant moxibustion
   therapy for aromatase inhibitor-induced arthralgia of postmenopausal
   breast cancer stage I to III patients Study protocol for a prospective,
   randomized, assessor-blind, usual-care controlled, parallel-group, pilot
   clinical trial
SO MEDICINE
LA English
DT Article
DE aromatase inhibitors; arthralgia; breast neoplasms; moxibustion;
   randomized controlled trial; traditional Korean medicine
ID ACUPUNCTURE; VALIDATION
AB Introduction: This study is a prospective, assessor-blinded, parallel-group, randomized controlled pilot trial to explore the effectiveness of 12-week adjuvant moxibustion therapy for arthralgia in menopausal females at stage I to III breast cancer on aromatase inhibitor (AI) administration, compared with those receiving usual care.
   Methods/design: Forty-six menopausal female patients with breast cancer who completed cancer therapy will be randomly allocated to either adjuvant moxibustion or usual care groups with a 1: 1 allocation ratio. The intervention group will undergo 24 sessions of adjuvant moxibustion therapy with usual care for 12 weeks, whereas the control group will receive only usual care during the same period. The usual care consists of acetaminophen administration on demand and self-directed exercise education to manage AI-related joint pain. The primary outcome is the mean change of the worst pain level according to the Brief Pain Inventory-Short Form between the initial visit and the endpoint. The mean changes in depression, fatigue, and quality of life will also be compared between groups. Safety and pharmacoeconomic evaluations will also be included.
   Discussion: Continuous variables will be compared by an independent t test or Wilcoxon rank-sum test between the adjuvant moxibustion and usual care groups. Adverse events will be analyzed using the chi-square or Fisher exact test. The statistical analysis will be performed by a 2-tailed test at a significance level of .05.
C1 [Shin, Seungwon] Kyung Hee Univ, Korean Med Hosp, Clin Trial Ctr, Seoul 02447, South Korea.
   [Jang, Bo-Hyoung] Kyung Hee Univ, Coll Korean Med, Dept Prevent Med, Seoul, South Korea.
   [Park, Seung-Hyeok; Lee, Jin-Wook; Chae, Min Soo; Kim, Namhoon] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, Seoul, South Korea.
   [Suh, Hae Sun] Pusan Natl Univ, Pharmaceut Econ Outcomes Res & Policy, Busan, South Korea.
   [Han, Sola] Pusan Natl Univ, Coll Pharm, Busan, South Korea.
   [Min, Sun Young] Kyung Hee Univ, Coll Med, Dept Surg, Seoul, South Korea.
   [Baek, Sun Kyung] Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Lim, Yu Jin] Kyung Hee Univ, Coll Med, Med Ctr, Dept Radiat Oncol, Seoul, South Korea.
   [Hwang, Deok-Sang] Kyung Hee Univ, Coll Korean Med, Dept Korean Obstet & Gynecol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Pusan
   National University; Pusan National University; Kyung Hee University;
   Kyung Hee University; Kyung Hee University; Kyung Hee University
RP Hwang, DS (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Korean Obstet & Gynecol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM soulhus@khu.ac.kr
RI Min, Sun/AAK-3757-2020; Jang, Bo-Hyoung/ABF-2923-2020; Han,
   Sola/ABE-5476-2021; Lim, Yu/AAJ-5422-2020; Shin, Seungwon/Q-4320-2016
OI Jang, Bo-Hyoung/0000-0002-2141-3483; Han, Sola/0000-0002-6269-172X;
   Park, Seung-Hyeok/0000-0002-9446-4046; 
FU Traditional Korean Medicine R&D Program - Ministry of Health and Welfare
   through the Korea Health Industry Development Institute (KHIDI)
   [HB16C0072]
FX This study was supported by the Traditional Korean Medicine R&D Program
   funded by the Ministry of Health and Welfare through the Korea Health
   Industry Development Institute (KHIDI; HB16C0072). The funding
   organization was not involved in study design, data collection, study
   management, or data analysis & interpretation.
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   [Anonymous], 1995, Kor J Psychopathol
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   Kim T. H., 2012, VALIDITY RELIABILITY
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NR 23
TC 1
Z9 2
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2019
VL 98
IS 38
AR e17260
DI 10.1097/MD.0000000000017260
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JB8AQ
UT WOS:000488788000070
PM 31568000
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Meng, ZQ
   Garcia, MK
   Chiang, JS
   Peng, HT
   Shi, YQ
   Fu, J
   Liu, LM
   Liao, ZX
   Zhang, Y
   Bei, WY
   Thornton, B
   Palmer, JL
   McQuade, J
   Cohen, L
AF Meng, Zhi-Qiang
   Garcia, M. Kay
   Chiang, Joseph S.
   Peng, Hui-Ting
   Shi, Ying-Qiang
   Fu, Jie
   Liu, Lu-Ming
   Liao, Zhong-Xing
   Zhang, Ying
   Bei, Wen-Ying
   Thornton, Bob
   Palmer, J. Lynn
   McQuade, Jennifer
   Cohen, Lorenzo
TI Electro-acupuncture to prevent prolonged postoperative ileus: A
   randomized clinical trial
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Acupuncture; Gastrointestinal motility; Gastrointestinal disorders;
   Gastrointestinal neoplasms
ID PLACEBO-CONTROLLED TRIAL; ADVANCED CANCER-PATIENTS; MAJOR
   ABDOMINAL-SURGERY; MU-OPIOID ANTAGONIST; PHASE-III TRIAL; CHRONIC
   CONSTIPATION; DOUBLE-BLIND; ACUPUNCTURE; ALVIMOPAN; METHYLNALTREXONE
AB AIM: To examine whether acupuncture can prevent prolonged postoperative ileus (PPOI) after intraperitoneal surgery for colon cancer.
   METHODS: Ninety patients were recruited from the Fudan University Cancer Hospital, Shanghai, China. After surgery, patients were randomized to receive acupuncture (once daily, starting on postoperative day 1, for up to six consecutive days) or usual care. PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery. The main outcomes were time to first flatus, time to first bowel movement, and electrogastroenterography. Secondary outcomes were quality of life (QOL) measures, including pain, nausea, insomnia, abdominal distension/fullness, and sense of well-being.
   RESULTS: No significant differences in PPOI on day 4 (P = 0.71) or QOL measures were found between the groups. There were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5 (P = 0.69) or day 6 (P = 0.88). No adverse events related to acupuncture were reported.
   CONCLUSION: Acupuncture did not prevent PPOI and was not useful for treating PPOI once it had developed in this population. (C) 2010 Baishideng. All rights reserved.
C1 [Meng, Zhi-Qiang; Peng, Hui-Ting; Fu, Jie; Liu, Lu-Ming] Fudan Univ, Canc Hosp, Dept Integrat Oncol, Shanghai 200032, Peoples R China.
   [Garcia, M. Kay] Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med Integrat Med, Houston, TX 77030 USA.
   [Chiang, Joseph S.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA.
   [Meng, Zhi-Qiang; Shi, Ying-Qiang; Fu, Jie; Liu, Lu-Ming; Zhang, Ying; Bei, Wen-Ying] Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China.
   [Shi, Ying-Qiang] Fudan Univ, Canc Hosp, Dept Abdominal Surg, Shanghai 200032, Peoples R China.
   [Liao, Zhong-Xing] Univ Texas Houston, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.
   [Zhang, Ying; Bei, Wen-Ying] Fudan Univ, Canc Hosp, Int Ctr Integrat Oncol, Shanghai 200032, Peoples R China.
   [Thornton, Bob] Univ Texas Houston, MD Anderson Canc Ctr, Dept Palliat Care & Rehabil Med, Houston, TX 77030 USA.
   [Palmer, J. Lynn; Cohen, Lorenzo] Univ Texas Houston, MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA.
   [McQuade, Jennifer] Univ Texas Houston, MD Anderson Canc Ctr, Dept GI Med Oncol, Houston, TX 77030 USA.
C3 Fudan University; University of Texas System; University of Texas Health
   Science Center Houston; UTMD Anderson Cancer Center; University of Texas
   System; UTMD Anderson Cancer Center; University of Texas Health Science
   Center Houston; Fudan University; University of Texas System; University
   of Texas Health Science Center Houston; UTMD Anderson Cancer Center;
   Fudan University; University of Texas System; UTMD Anderson Cancer
   Center; University of Texas Health Science Center Houston; University of
   Texas System; University of Texas Health Science Center Houston; UTMD
   Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer
   Center; University of Texas Health Science Center Houston
RP Liu, LM (corresponding author), Fudan Univ, Canc Hosp, Dept Integrat Oncol, Shanghai 200032, Peoples R China.
EM llm1010@163.com
FU US National Cancer Institute (NCI) [CA108084, CA12153031]
FX Supported by US National Cancer Institute (NCI) grants CA108084 and
   CA12153031
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NR 49
TC 61
Z9 72
U1 2
U2 43
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 7
PY 2010
VL 16
IS 1
BP 104
EP 111
DI 10.3748/wjg.v16.i1.104
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 542CE
UT WOS:000273468100014
PM 20039456
DA 2026-01-16
ER

PT J
AU Paley, CA
   Johnson, MI
   Bennett, MI
AF Paley, Carole A.
   Johnson, Mark I.
   Bennett, Michael I.
TI Should physiotherapists use acupuncture for treating patients with
   cancer-induced bone pain? A discussion paper
SO PHYSIOTHERAPY
LA English
DT Editorial Material
DE Acupuncture; Pain; Cancer; Metastases; Bone
ID RAT MODEL; COMPLEMENTARY/ALTERNATIVE MEDICINE; STIMULATION; MORPHINE;
   BRAIN; ELECTROACUPUNCTURE; INTERLEUKIN-1-BETA; MECHANISMS; EXPRESSION;
   ANALGESIA
AB Background Patients suffering from pain due to bony metastases in cancer represent a challenge to the physiotherapist as part of the multidisciplinary team. Adequate pain relief improves quality of life and functional status, yet conventional analgesia often has undesirable side-effects and non-pharmacological treatments (e. g. some electrotherapies) may be contraindicated in cancer. Acupuncture is a potential treatment for cancer-induced bone pain (CIBP) as it has few side effects and is relatively easy to administer. There is a dearth of research on the use of acupuncture in treating CIBP and some practitioners express fears about treating cancer patients with acupuncture.
   Objectives To discuss the use of acupuncture for CIBP by reviewing the physiological rationale for using acupuncture to treat CIBP and the risks and benefits of using acupuncture in clinical practice.
   Data Sources Evidence was identified by searching seven major databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, PsycINFO, AMED and SPORTDiscus. Evidence was synthesised by the authors to raise issues and discussion points within a narrative review framework.
   Findings Available physiological evidence supports potentially efficacious effects of acupuncture for reduction of CIBP. Clinical literature suggests that acupuncture may be effective as an adjunctive treatment for CIBP and that risks are manageable. However, there is a need for well-designed randomised controlled trials to investigate efficacy and effectiveness in patients.
   Conclusions Acupuncture has the potential to provide sustained background analgesia and/or rapid onset analgesia for breakthrough pain if the appropriate points and techniques are used. (C) 2010 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.
C1 [Paley, Carole A.] Airedale NHS Fdn Trust, Steeton BD20 6TD, Keighley, England.
   [Paley, Carole A.; Johnson, Mark I.] Leeds Metropolitan Univ, Fac Hlth, Leeds LS1 3HE, W Yorkshire, England.
   [Bennett, Michael I.] Univ Lancaster, Sch Hlth & Med, Int Observ End Life Care, Lancaster, England.
C3 Leeds Beckett University; Lancaster University
RP Paley, CA (corresponding author), Airedale NHS Fdn Trust, Skipton Rd, Steeton BD20 6TD, Keighley, England.
EM biodynamics.physiotherapy@tesco.net
RI Paley, Carole Anne/AAM-2469-2020; Bennett, Michael/A-1620-2009
OI Paley, Carole Anne/0000-0002-6335-2666; Bennett,
   Michael/0000-0002-8369-8349
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NR 99
TC 6
Z9 9
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0031-9406
EI 1873-1465
J9 PHYSIOTHERAPY
JI Physiotherapy
PD SEP
PY 2011
VL 97
IS 3
BP 256
EP 263
DI 10.1016/j.physio.2010.08.008
PG 8
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA 803GF
UT WOS:000293569100012
PM 21820545
DA 2026-01-16
ER

PT J
AU Xue, YH
   Zhu, QB
   Zhang, J
   Wang, XF
AF Xue, Yahong
   Zhu, Qinbing
   Zhang, Jing
   Wang, Xiaofeng
TI Electroacupuncture alleviates capsaicin-induced rectal visceral pain in
   rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38
   pathway
SO PURINERGIC SIGNALLING
LA English
DT Article
DE Electroacupuncture; P38 mitogen-activated protein kinase; Transient
   receptor potential vanilloid-1; Rectal visceral pain; Disease
ID ACUPUNCTURE; MECHANISMS; HYPERALGESIA; BLOCKADE; RECEPTOR; AXIS
AB Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects on various acute and chronic pain. It has been proved to ameliorate chronic visceral pain, but its specific role in rectal visceral pain remains underexplored. A capsaicin (CAP)-induced visceral pain rat model was established, and behavioral pain responses were observed and recorded. Measurement of mechanical pain threshold was performed using electronic Von Frey system. Rectal tissues, and the activity of microglia cells were detected by Hematoxylin/eosin staining and immunofluorescence, respectively. Contents of interleukin (IL)-6, IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay. Western blot was performed to determine the expressions of P2X4 receptor (P2X4R), p38 mitogen-activated protein kinase (p38), phosphorylated p38 (p-p38), transient receptor potential vanilloid-1 (TRPV1) and ionized calcium binding adapter molecule 1 (Iba-1). Transfection efficiency of TRPV1 overexpression plasmids was examined by quantitative real-time polymerase chain reaction. EA abrogated CAP-induced upregulation of behavioral pain responses and mechanical threshold, damage on rectal tissue, activation of microglia, stimulation of inflammatory response and promotion of P2X4R-p38-TRPV1 pathway expressions in rats, while P2X4R activation reversed the effect of EA. P2X4R antagonist weakened CAP-induced upregulation of P2X4R-p38-TRPV1 pathway expressions, microglia activation as well as increase of IL-1 beta in HMO6 cells, which was reversed by TRPV1 overexpression. Collectively, EA improves CAP-induced rectal visceral pain via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway in microglia. However, the specificity role of P2X4R needs to be confirmed by more experiment.
C1 [Xue, Yahong; Wang, Xiaofeng] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Dept Anorectal, Nanjing 210022, Jiangsu, Peoples R China.
   [Zhu, Qinbing; Zhang, Jing] Nanjing Univ Chinese Med, Grad Sch, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Xue, YH (corresponding author), Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Dept Anorectal, Nanjing 210022, Jiangsu, Peoples R China.
EM xueyahong_1983@126.com
FU National Natural Science Foundation of China
FX Not applicable.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1573-9538
EI 1573-9546
J9 PURINERG SIGNAL
JI Purinergic Signal.
PD AUG
PY 2025
VL 21
IS 4
SI SI
BP 565
EP 576
DI 10.1007/s11302-025-10100-y
EA JUN 2025
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 7PA8H
UT WOS:001516518900001
PM 40560521
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Sun, LX
   Wei, XQ
   Feng, TA
   Gu, QH
   Li, J
   Wang, K
   Zhou, J
AF Sun, Linxi
   Wei, Xuqiang
   Feng, Tienan
   Gu, Qunhao
   Li, Jing
   Wang, Ke
   Zhou, Jia
TI Electroacupuncture promotes gastrointestinal functional recovery after
   radical colorectal cancer surgery: a protocol of multicenter randomized
   controlled trial (CORRECT trial)
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Electroacupuncture; Colorectal cancer surgery; Gastrointestinal
   functional recovery; Enhanced Recovery After Surgery; Randomized
   controlled trial; Protocol
ID CLINICAL-PRACTICE GUIDELINES; POSTOPERATIVE ILEUS; ENHANCED RECOVERY;
   HIGH-FREQUENCY; ACUPUNCTURE; STIMULATION; DIAGNOSIS; MOTILITY; RELEASE;
   COLON
AB IntroductionThe incidence of postoperative gastrointestinal dysfunction (POGD) is notably high among patients following colorectal cancer surgery, highlighting the urgency for the prompt development of efficacious preventive and therapeutic approaches. Electroacupuncture (EA) represents an intervention modality that holds promise for the management of POGD. However, the existing empirical evidence substantiating its efficacy remains scarce. The aim of this study is to evaluate the efficacy and safety of EA as a treatment for POGD in patients undergoing colorectal cancer surgery.MethodsThis study is a multicenter, parallel-group, randomized controlled trial, named as CORRECT. CORRECT trial will recruit 300 participants diagnosed with colorectal cancer and about to undergo radical surgery across four sub-centers. The participants will be randomly assigned to one of three groups: the EA group, sham-electroacupuncture group, or control group, with a randomization ratio of 2:2:1. All groups will follow a standardized Enhanced Recovery After Surgery (ERAS) protocol. The EA group will receive EA at acupoints LI4, SJ6, ST36, and ST37, while the SA group will undergo sham-electroacupuncture. The treatments will be administered twice daily from the day of surgery until the fourth day after the operation. The primary endpoint is the time to first flatus, while secondary endpoints encompass time to first defecation, bowel sound emergence, initial water intake, duration of postoperative hospitalization, nausea and vomiting, pain levels, and blinded evaluations. Additional outcomes include medication usage and complication rates, et al.DiscussionThe CORRECT trial aims to provide high-quality evidence for the role of EA in the treatment of POGD following colorectal cancer surgery. It will contribute data towards the integration of acupuncture into ERAS protocols. Insights from the trial could help in tailoring treatment plans based on individual patient responses to EA, optimizing care on a case-by-case basis.Trial registrationClinical Trial Registry registration was approved by the ClinicalTrials.gov committee on November 2023 with the ClinicalTrials.gov Identifier: NCT06128785. URL: https://clinicaltrials.gov/study/NCT06128785?tab=history&a=1#study-details-card.
C1 [Sun, Linxi; Wei, Xuqiang; Wang, Ke; Zhou, Jia] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Acupuncture Anesthesia Clin Res Inst, Shanghai, Peoples R China.
   [Feng, Tienan] Shanghai Jiao Tong Univ, Clin Res Inst, Sch Med, 227 South Chongqing Rd, Shanghai 200025, Peoples R China.
   [Gu, Qunhao] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Gastrointestinal Surg Dept, Shanghai, Peoples R China.
   [Li, Jing] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Acupuncture & Moxibust 2, Shanghai, Peoples R China.
   [Wang, Ke; Zhou, Jia] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Off Natl Clin Res Base TCM, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai Jiao Tong
   University; Shanghai University of Traditional Chinese Medicine;
   Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Wang, K; Zhou, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Acupuncture Anesthesia Clin Res Inst, Shanghai, Peoples R China.; Wang, K; Zhou, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Off Natl Clin Res Base TCM, Shanghai, Peoples R China.
EM wangke8430@163.com; pdzhoujia@163.com
OI Wei, Xuqiang/0000-0001-6008-5681
FU Program for Training Excellent Doctoral Students in Key Areas
FX Thanks to the doctors (Xiaoming Zhu, Hui Chen, Xiaochen Cai, Jiahui
   Shen, Zhenlin Luo, Li Bao, Xiaobin Yao, etc.), nurses, and patients from
   4 hospitals for their support.
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NR 57
TC 6
Z9 7
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD DEC 9
PY 2024
VL 39
IS 1
AR 198
DI 10.1007/s00384-024-04768-8
PG 13
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA O7K9Q
UT WOS:001372882100001
PM 39652211
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zhou, Y
   Zhang, MM
   Yang, C
   Li, SH
   Guixing, X
   Zihan, Y
   Sun, MS
   Yang, J
   Wang, YY
   Dai, W
   He, YY
   Han, L
   Lin, J
   Liang, FR
   Liu, F
AF Zhou, Yan
   Zhang, Mingming
   Yang, Chen
   Li, Shu-Hao
   Guixing, Xu
   Zihan, Yin
   Sun, Ming-Sheng
   Yang, Jiao
   Wang, Yang-Yang
   Dai, Wei
   He, Yueyi
   Han, Lin
   Lin, Jie
   Liang, Fan-rong
   Liu, Fang
TI Effect of electroacupuncture versus sham electroacupuncture on
   postoperative ileus after laparoscopic surgery for left-sided colorectal
   cancer: study protocol for a multicentre, randomised, sham-controlled
   trial
SO BMJ OPEN
LA English
DT Article
DE COMPLEMENTARY MEDICINE; GASTROENTEROLOGY; Gastrointestinal tumours;
   Acupuncture
ID QUALITY-OF-LIFE; GASTROINTESTINAL MOTILITY; CLINICAL-TRIAL; RECOVERY;
   VALIDATION; COLECTOMY; DURATION
AB Introduction Postoperative ileus (POI) is an inevitable complication after abdominal surgery, often hindering recovery and prolonging hospital stay. Despite the increasing use of electroacupuncture (EA) as an alternative treatment for gastrointestinal dysfunction, its effectiveness for POI is still controversial. This study aims to verify the efficacy and safety of EA in alleviating POI.Methods and design The study is a multicentre, randomised, sham-controlled trial. A total of 174 patients undergoing laparoscopic surgery for left-sided colorectal cancer will be randomly assigned to an EA group and a sham acupuncture group at a ratio of 1:1. Treatment for both groups will commence on the first day after the operation and continue once a day for four consecutive days. The primary outcome is time to first defecation. Secondary outcomes include time to first flatus, time to first tolerance to liquid and semiliquid diet, Functional Assessment of Cancer Therapy-Colorectal (FACT-C, V.4.0), postoperative nausea and vomiting, postoperative pain and abdominal distension, the Gastrointestinal Quality of Life Index, Self-Rating Depression Scale, Self-Rating Anxiety Scale, Gastrointestinal Symptom Rating Scale, length of the postoperative hospital stay, time to first postoperative ambulation, evaluation of the expected value of acupuncture, and satisfaction evaluation.Ethics and dissemination The results will be disseminated through peer-reviewed publications. This study protocol (V.2.0, 1 October 2023) involves human participants and has been approved by the Ethics Committee of Sichuan Cancer Hospital (number KY-2023-041-01), Meishan Hospital of Traditional Chinese Medicine (number 2024LC001) and The Seventh People's Hospital of Chengdu (number KY2024-001-01). Each individual who agrees to participate in the research will provide written informed consent after the objectives and procedures of this study are explained to them.Trial registration number ChiCTR2400079645. Registered on 8 January 2024.
C1 [Zhou, Yan] Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
   [Zhang, Mingming] Sichuan Univ, West China Hosp, Dept Gen Surg, Chengdu, Sichuan, Peoples R China.
   [Zhang, Mingming] Sichuan Univ, West China Hosp, West China Hosp, Chengdu, Sichuan, Peoples R China.
   [Yang, Chen; Li, Shu-Hao; Zihan, Yin; Sun, Ming-Sheng; Wang, Yang-Yang; Liang, Fan-rong] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
   [Guixing, Xu] Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Yang, Jiao] Sichuan Univ, West China Hosp, Rehabil Med Ctr, Chengdu, Sichuan, Peoples R China.
   [Dai, Wei] Univ Elect Sci & Technol China, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr, Sichuan Canc Hosp & Inst,Affiliated Canc Hosp,Dept, Chengdu, Sichuan, Peoples R China.
   [He, Yueyi] Meishan Hosp Tradit Chinese Med, Chengdu, Peoples R China.
   [Han, Lin; Lin, Jie] Chengdu Seventh Peoples Hosp, Chengdu, Peoples R China.
   [Liu, Fang] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Hosp,Affiliated Canc Hosp,Dept Integr, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Sichuan University;
   Sichuan University; Chengdu University of Traditional Chinese Medicine;
   Chengdu University of Traditional Chinese Medicine; Sichuan University;
   University of Electronic Science & Technology of China; University of
   Electronic Science & Technology of China
RP Liu, F (corresponding author), Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Hosp,Affiliated Canc Hosp,Dept Integr, Chengdu, Sichuan, Peoples R China.
EM zhouyan@stu.cdutcm.edu.cn; mmzhangmd@163.com; yccandyc@163.com;
   1260195295@qq.com; xuguixing@stu.cdutcm.edu.cn;
   yinzihan@stu.cdutcm.edu.cn; sunmingsheng@cdutcm.edu.cn;
   yangjiao@wchscu.cn; yfwwyy@163.com; daiwei@sichuancancer.org;
   msheyueyi@126.com; 313555231@qq.com; 346205383@qq.com;
   acuresearch@126.com; liufang@scszlyy.org.cn
RI Dai, Wei/ABP-4071-2022
OI Dai, Wei/0000-0003-1650-1590
FU Sichuan Province Key Research and Development Project [2023YFS0328];
   Youth Fund Project of National Natural Science Foundation of China
   [82305380]
FX This study is financially supported by the Sichuan Province Key Research
   and Development Project (grant number 2023YFS0328) and Youth Fund
   Project of National Natural Science Foundation of China (grant number
   82305380).
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NR 62
TC 0
Z9 1
U1 2
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC 25
PY 2024
VL 14
IS 12
AR e086438
DI 10.1136/bmjopen-2024-086438
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q2R7Z
UT WOS:001383226100001
PM 39725420
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Lopes, LC Jr
   Rosa, GS
   Pessanha, RM
   Schuab, SIPD
   Nunes, KZ
   Amorim, MHC
AF Lopes-Junior, Luis Carlos
   Rosa, Gabriela Sylvestre
   Pessanha, Raphael Manhaes
   de Carvalho Schuab, Sara Isabel Pimentel
   Nunes, Karolini Zuqui
   Costa Amorim, Maria Helena
TI Efficacy of the complementary therapies in the management of cancer pain
   in palliative care: A systematic review
SO REVISTA LATINO-AMERICANA DE ENFERMAGEM
LA English
DT Review
DE Descriptors: Complementary Therapies; Adult; Cancer Pain; Palliative
   Care; Oncology Nursing; Evidence-Based Nursing
ID RANDOMIZED CONTROLLED-TRIAL; AROMATHERAPY MASSAGE; GUIDED IMAGERY;
   BREAST-CANCER; OF-LIFE; FATIGUE; INTERVENTION; EXPERIENCES; ADOLESCENTS;
   RELAXATION
AB Objective: to synthesize the knowledge and to critically evaluate the evidences arising from randomized controlled trials on the efficacy of the complementary therapies in the management of cancer pain in adult patients with cancer in palliative care. Method: a systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The search for articles in the MEDLINE, ISI Web of Knowledge, CENTRAL Cochrane, and PsycINFO databases, as well as the manual search, selection of studies, data extraction, and methodological assessment using the Cochrane Bias Risk tool were performed independently by two reviewers. Results: eight hundred and fifteen (815) studies were identified, six of them being selected and analyzed, of which three used massage therapy, one study used a combination of progressive muscle relaxation and guided imaging, and another two studies used acupuncture. Most of the studies had an uncertain risk of bias (n=4; 67%). Conclusion: while the evidence from the studies evaluating the use of massage therapy or the use of progressive muscle relaxation and guided imaging for the management of cancer pain in these patients demonstrated significant benefits, the other two studies that evaluated the use of acupuncture as a complementary therapy showed contradictory results, therefore, needing more research studies to elucidate such findings.
C1 [Lopes-Junior, Luis Carlos; Rosa, Gabriela Sylvestre; Pessanha, Raphael Manhaes; de Carvalho Schuab, Sara Isabel Pimentel; Nunes, Karolini Zuqui] Univ Fed Espirito Santo, Dept Enfermagem, Vitoria, ES, Brazil.
   [Costa Amorim, Maria Helena] Univ Fed Sao Paulo, Escola Paulista Enfermagem, Sao Paulo, SP, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal de Sao
   Paulo (UNIFESP)
RP Lopes, LC Jr (corresponding author), Univ Fed Espirito Santo, Dept Enfermagem, Vitoria, ES, Brazil.
EM lopesjr.lc@gmail.com
RI ; Lopes-Júnior, Luís Carlos/B-8540-2015; Costa Amorim, Maria
   Helena/AAX-3042-2020; Rosa, Gustavo/AAT-4939-2021; Schuab, Sara Isabel
   Pimentel de Carvalho/OUH-2401-2025
OI Nunes, Karolini Zuqui/0000-0003-3433-4925; Lopes-Júnior, Luís
   Carlos/0000-0002-2424-6510; Pessanha, Raphael
   Manhães/0000-0001-6893-0755; Costa Amorim, Maria
   Helena/0000-0002-4252-7092; Schuab, Sara Isabel Pimentel de
   Carvalho/0000-0002-8372-325X; 
FU Fundacao de Amparo a Pesquisa e Inovacao do Espirito Santo (FAPES)
   [359/2019]
FX Supported by Fundacao de Amparo a Pesquisa e Inovacao do Espirito Santo
   (FAPES), Grant # 359/2019, Brazil.
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NR 56
TC 33
Z9 52
U1 1
U2 41
PU UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO
PI RIBEIRAO PRETO
PA AV BANDEIRANTES, 3900, RIBEIRAO PRETO, SP 14040-902  A, BRAZIL
SN 1518-8345
J9 REV LAT-AM ENFERM
JI Rev. Latino-Am. Enfermagem
PY 2020
VL 28
AR e3377
DI 10.1590/1518-8345.4213.3377
PG 17
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA NY0QL
UT WOS:000576104400001
PM 33027406
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Bell, BK
   Cha, JY
   Cavanaugh, KA
   O'Riordan, DL
   Rabow, MW
   Yang, AK
   Patel, S
   Park, SH
   Mcgrath, MK
   Whitaker, EM
   Nouri, SS
   Cheng, SW
AF Bell, Brieze K.
   Cha, Jaeyoon
   Cavanaugh, Kathleen A.
   O'Riordan, David L.
   Rabow, Michael W.
   Yang, Adrienne K.
   Patel, Sohil
   Park, Sa Heen
   Mcgrath, Megan K.
   Whitaker, Evans M.
   Nouri, Sarah S.
   Cheng, Stephanie W.
TI Integrative Management of Cancer Pain: A Scoping Review of the
   Literature
SO CANCER MEDICINE
LA English
DT Review
DE acupuncture; cancer pain; complementary and alternative medicine;
   integrative health; integrative medicine; integrative oncology;
   mindfulness
ID PROGRESSIVE MUSCLE-RELAXATION; BREAST-CANCER; MUSCULOSKELETAL SYMPTOMS;
   AROMATASE INHIBITORS; GUIDED IMAGERY; DOUBLE-BLIND; ACUPUNCTURE;
   COMPLEMENTARY; MEDICINE; WOMEN
AB Background: Cancer-related pain is common and debilitating. Patients frequently use integrative medicine therapies to manage this, though safety and efficacy evidence is incomplete. This scoping review aims to characterize the state of integrative cancer pain therapy (ICPT) and identify priorities for future research. Methods: Following PRISMA guidelines, we searched PubMed, Embase, Web of Science, PsycINFO, CINAHL, and Cochrane for ICPT studies published between January 1, 1975 and May 26, 2022. Study findings were extracted and analyzed using descriptive statistics and thematic analysis. Interventions were categorized as follows: Whole Systems of Medicine (WSM); Mind-body Medicine (MBM); Botanicals and Supplements (BAS); and Manual Therapies (MT). Quality appraisal was performed using the Downs and Black checklist. Efficacy was "positive" if there were statistically significant differences between study arms (p < 0.05) favoring ICPT. Results: Among 1246 studies reviewed, 151 met inclusion criteria; 63.5% were excellent or good quality, and 68.9% were RCTs; 122 studies (80.7%) were published since 2010. Studies occurred in 24 countries, in variable settings, among participants with a wide range of cancers, disease status, and age ranges. Studies investigating WSM and MBM interventions were most frequent (35.7% for each), MT (20.59%), and BAS (7.9%). Overall, of the included studies, 127 (84.1%) found that the ICPT intervention reduced pain. Conclusions: Studies on ICPT are increasingly common, and the majority of ICPT interventions demonstrated a positive impact on cancer pain. Future rigorous research should compare efficacy across integrative and biomedical interventions and explore how to incorporate evidence-based ICPT into standard cancer treatment.
C1 [Bell, Brieze K.; Cavanaugh, Kathleen A.; O'Riordan, David L.; Rabow, Michael W.; Yang, Adrienne K.; Patel, Sohil; Park, Sa Heen; Mcgrath, Megan K.; Nouri, Sarah S.; Cheng, Stephanie W.] Univ Calif San Francisco, San Francisco, CA 94115 USA.
   [Cha, Jaeyoon] Harvard Med Sch, Boston, MA USA.
   [Rabow, Michael W.] Supported Mt Zion Hlth Fund, MERI Ctr Educ Palliat Care, San Francisco, CA USA.
   [Whitaker, Evans M.] Stanford Univ, Sch Med, Palo Alto, CA USA.
C3 University of California System; University of California San Francisco;
   Harvard University; Harvard Medical School; Stanford University
RP Bell, BK (corresponding author), Univ Calif San Francisco, San Francisco, CA 94115 USA.
EM brieze.bell@ucsf.edu
RI Whitaker, Evans/IAM-5241-2023
OI Whitaker, Evans/0000-0003-1326-4374; Cha, Jaeyoon/0000-0003-1436-369X
FU Mount Zion Health Fund; MERI Center for Education in Palliative Care
FX We gratefully acknowledge the financial support from the Mount Zion
   Health Fund and the MERI Center for Education in Palliative Care for
   this project. The sponsors had no involvement in the design and conduct
   of the project; the collection, management, analysis, or interpretation
   of the data; or in the preparation, review, or approval of the article.
   Contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the funders.
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NR 69
TC 0
Z9 0
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2045-7634
J9 CANCER MED-US
JI Cancer Med.
PD MAY 3
PY 2025
VL 14
IS 9
AR e70833
DI 10.1002/cam4.70833
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2EI2N
UT WOS:001480621300001
PM 40317896
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Cha, MH
   Nam, TS
   Kwak, Y
   Lee, H
   Lee, BH
AF Cha, Myeoung Hoon
   Nam, Taick Sang
   Kwak, Yongho
   Lee, Hyejung
   Lee, Bae Hwan
TI Changes in Cytokine Expression after Electroacupuncture in Neuropathic
   Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID HIV-1 ENVELOPE GLYCOPROTEIN; TEMPORAL EXPRESSION; ANTI-HYPERALGESIA;
   MESSENGER-RNA; NERVE INJURY; ANIMAL-MODEL; PAIN; ACTIVATION;
   ACUPUNCTURE; ALLODYNIA
AB The production of proinflammatory cytokines including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) plays a key role in chronic pain such as neuropathic pain. We investigated changes in cytokine expression in injured peripheral nerves and dorsal root ganglia (DRG) following electroacupuncture (EA) treatment. Neuropathic pain was induced by peripheral nerve injury to the left hind limb of Sprague-Dawley rats under pentobarbital anesthesia. Two weeks later, the nerve-injured rats were treated by EA for 10 minutes. The expression levels of IL-1 beta, IL-6, and TNF-alpha in peripheral nerves and DRG of neuropathic rats were significantly increased in nerve-injured rats. However, after EA, the cytokine expression levels were noticeably decreased in peripheral nerves and DRG. These results suggest that EA stimulation can reduce the levels of proinflamtory cytokines elevated after nerve injury.
C1 [Cha, Myeoung Hoon; Nam, Taick Sang; Kwak, Yongho; Lee, Bae Hwan] Yonsei Univ, Coll Med, Dept Physiol, Seoul 120752, South Korea.
   [Cha, Myeoung Hoon; Nam, Taick Sang; Kwak, Yongho; Lee, Bae Hwan] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea.
   [Lee, Hyejung] Kyung Hee Univ, Acupuncture & Meridian Sci Res Ctr, Seoul 130701, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Kyung Hee University
RP Lee, BH (corresponding author), Yonsei Univ, Coll Med, Dept Physiol, POB 8044, Seoul 120752, South Korea.
EM bhlee@yuhs.ac
RI ; Cha, Myeounghoon/ABI-2748-2020
OI Lee, Bae H/0000-0003-4719-9021; Cha, Myeounghoon/0000-0002-7993-672X
FU National Research Foundation (NRF) of Korea; Ministry of Education,
   Science and Technology [2005-0049404]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation (NRF) of Korea funded by the Ministry
   of Education, Science and Technology (no. 2005-0049404).
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NR 28
TC 28
Z9 32
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 792765
DI 10.1155/2012/792765
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 906VS
UT WOS:000301377600001
PM 22454684
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Jia, LT
   Wang, KY
   Chen, SQ
AF Jia, Liting
   Wang, Keyi
   Chen, Shuquan
TI Acupuncture combined with opioid for treatment of lung cancer-related
   pain: A systematic review and meta-analysis
SO MEDICINE
LA English
DT Article
DE acupuncture; lung cancer; meta-analysis; opioids; pain
ID QUALITY-OF-LIFE; MANAGEMENT; MOXIBUSTION; MECHANISMS; BURDEN
AB Background: Many individuals diagnosed with lung cancer suffer from tremendous pain, and it is crucial to implement more effective measures to assist these patients in alleviating their pain. The present study utilizes a meta-analysis to evaluate the safety and efficacy of acupuncture combined with opioids for treating lung cancer-related pain in patients. Methods: We have searched 8 electronic databases: The Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and SinoMed. We included all randomized controlled trials of acupuncture combined with opioids for lung cancer-related pain in adults. We observed the main outcome indicators, including pain relief rates, numeric rating scale scores, and adverse events. Two researchers independently conducted literature screening, literature data extraction, and assessment of bias risk in the literature quality. Any disagreements were resolved through discussions between the 2 researchers or consultations with a third researcher. The risk of bias in the included studies was assessed using the revised risk of bias assessment tool. The overall quality of evidence for each outcome was evaluated using Grading of Recommendations, Assessment, Development and Evaluations. Results: We retrieved 812 lung cancer patients from 11 trials. The study showed that compared to opioids alone, the combination of acupuncture and opioids significantly reduced numeric rating scale scores, increased pain relief rates, and decreased the occurrence of side effects. Conclusion: The current evidence indicates that combining acupuncture with opioid analgesics is superior to using opioid analgesics alone for managing lung cancer-related pain. Additionally, this combination therapy has fewer adverse reactions.
C1 [Jia, Liting; Wang, Keyi; Chen, Shuquan] Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
   [Chen, Shuquan] Jinan Integrated Tradit Chinese & Western Med Hosp, Jinan 271100, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine
RP Chen, SQ (corresponding author), Jinan Integrated Tradit Chinese & Western Med Hosp, Jinan 271100, Shandong, Peoples R China.
EM lwcsq001@163.com
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NR 39
TC 2
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 18
PY 2024
VL 103
IS 42
AR e40158
DI 10.1097/MD.0000000000040158
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M6F8B
UT WOS:001358481200007
PM 39432621
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Rosenscheg, M
   Pedron, J
   Pedroso, L
AF Rosenscheg, Marcelen
   Pedron, Julia
   Pedroso, Lorena
TI Treatment of Cancer Pain
SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
LA English
DT Review
DE cancer pain; pain management; complementary therapies; medical oncology;
   interdisciplinary research
ID BREAST-CANCER; BUPRENORPHINE; THERAPY; IMPACT; SCALE
AB Contextualization:One of the biggest problems regarding the treatment of cancer patients is pain, whether due to the cancer or the treatment itself. Therefore, there is a search for treatments that aims to promote an effective treatment in this sense.Purpose:This article aims to verify which are the recent methods used to treat pain in cancer patients in a multidisciplinary sense, and to evaluate their effectiveness.Methodology:Systematic reviews, meta-analyses and randomized clinical trials utilizing the LILACS, NCBI, and MEDLINE platforms of the last 5 years were included. The descriptors were pain treatment in oncology, pain management, complementary therapies, and other synonyms, in Portuguese, English and Spanish. This included any technique that was effective in the treatment of cancer pain.Results:The initial search found 2246 articles, of which 22 were included in the systematic review. Most of these are acupuncture treatments, opioids versus anti-inflammatories versus analgesics, radiotherapy, behavioral therapies, among others. Most articles suggest benefits with these therapies, improved quality of life for patients and tolerable side effects.Conclusion:This study demonstrates the effectiveness of the current methods used in the treatment of pain in cancer patients so that professionals in the area can have more options for treating cancer pain. Despite the important limitations, the guideline for further research and the situations in which treatments have shown effectiveness are present in it.
C1 [Rosenscheg, Marcelen; Pedron, Julia; Pedroso, Lorena] Ctr Univ Campo Real, Bonding Inst, Guarapuava, PR, Brazil.
RP Rosenscheg, M (corresponding author), Ctr Univ Campo Real, Bonding inst, St Afonso Botelho 348, BR-85012030 Guarapuava, PR, Brazil.
EM med-marcelenrosenscheg@camporea.edu.br;
   med-juliapedron@camporeal.edu.br; med-lorenapedroso@camporeal.edu.br
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NR 36
TC 4
Z9 4
U1 2
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-3732
EI 1537-453X
J9 AM J CLIN ONCOL-CANC
JI Am. J. Clin. Oncol.-Cancer Clin. Trials
PD OCT
PY 2023
VL 46
IS 10
BP 450
EP 458
DI 10.1097/COC.0000000000001029
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA S6GP7
UT WOS:001072129900005
PM 37482642
DA 2026-01-16
ER

PT J
AU Hsieh, YL
   Chou, LW
   Hong, SF
   Chang, FC
   Tseng, SW
   Huang, CC
   Yang, CH
   Yang, CC
   Chiu, WF
AF Hsieh, Yueh-Ling
   Chou, Li-Wei
   Hong, Shao-Fu
   Chang, Fei-Chi
   Tseng, Szu-Wen
   Huang, Chi-Chou
   Yang, Ching-Hsiang
   Yang, Chen-Chia
   Chiu, Wei-Feng
TI Laser acupuncture attenuates oxaliplatin-induced peripheral neuropathy
   in patients with gastrointestinal cancer: a pilot prospective cohort
   study
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE ONCOLOGY
ID LOW-LEVEL LASER; CARPAL-TUNNEL SYNDROME; COLORECTAL-CANCER;
   BREAST-CANCER; MANAGEMENT; PAIN; ELECTROACUPUNCTURE; THERAPY;
   NEUROTOXICITY; SURVIVORS
AB Background Oxaliplatin is a platinum compound that is widely used in the treatment of some solid tumours. Oxaliplatin-induced peripheral neuropathy (OIPN) in the upper and lower extremities is the major adverse side effect and represents the main dose-limiting factor of this drug. The aim of this single-arm study was to evaluate the feasibility and effects of laser acupuncture (LA) in the treatment of OIPN in patients with advanced gastrointestinal cancers.
   Methods 17 gastrointestinal cancer survivors (14 colorectal and 3 gastric cancers), who had been treated with oxaliplatin-based chemotherapies, were recruited. Low-level laser stimulation (50mW) bilaterally at PC6, PC7, PC8, P9, LU11, SP6, KI3, BL60, KI1, and KI2 was administered for 20min/point for 12 sessions over 4weeks. The pain quality assessment scale (PQAS), chemotherapy-induced neurotoxicity questionnaire (CINQ), oxaliplatin-specific neurotoxicity scale (OSNS), quantitative touch-detection threshold (using von Frey filaments), and cold-triggered pain withdrawal latency (using the cold-water immersion test) were measured before and after completion of the 12 treatment sessions.
   Results PQAS, CINQ, and OSNS scores, as well as touch-detection threshold and cold-trigger pain withdrawal latency all improved significantly after LA in the cancer patients with OIPN (p<0.05). LA significantly relieved both oxaliplatin-induced cold and mechanical allodynia and also decreased the incidence and severity of neurotoxicity symptoms in the patients' upper and lower extremities and impact on their daily activities (all p<0.05).
   Conclusions Following treatment with LA, neurotoxicity symptoms were significantly improved in cancer patients with OIPN. Further randomised controlled trials are needed to evaluate the role of LA as a therapeutic option in the management of OIPN.
C1 [Hsieh, Yueh-Ling; Hong, Shao-Fu; Yang, Ching-Hsiang] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan.
   [Chou, Li-Wei] China Med Univ, Grad Inst Acupuncture Sci, Coll Chinese Med, Taichung, Taiwan.
   [Chou, Li-Wei] China Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.
   [Hong, Shao-Fu] Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Chung Shing Branch, Taichung, Taiwan.
   [Chang, Fei-Chi] Chung Shan Med Univ Hosp, Dept Nursing, Taichung, Taiwan.
   [Tseng, Szu-Wen] Chung Shan Med Univ Hosp, Div Med Oncol, Dept Internal Med, Taichung, Taiwan.
   [Huang, Chi-Chou] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Huang, Chi-Chou] Chung Shan Med Univ Hosp, Div Colon & Rectum, Dept Surg, Taichung, Taiwan.
   [Yang, Chen-Chia; Chiu, Wei-Feng] Cheng Ching Gen Hosp, Dept Phys Med & Rehabil, Taichung 40407, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Hospital - Taiwan;
   Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital
RP Chiu, WF (corresponding author), Cheng Ching Gen Hosp, Dept Phys Med & Rehabil, Taichung 40407, Taiwan.
EM chengchingchiu@gmail.com; chengchingchiu@gmail.com
RI Chou, Li-Wei/M-6409-2013; Hsieh, Yueh-Ling/M-2430-2013
FU Ministry of Science and Technology [NSC101-2314-B-039-003-MY2]; Cheng
   Ching General Hospital in Taiwan [CH10500197]
FX The study was funded by grants from the Ministry of Science and
   Technology [NSC101-2314-B-039-003-MY2] and Cheng Ching General Hospital
   [CH10500197] in Taiwan.
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NR 36
TC 37
Z9 40
U1 0
U2 31
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD OCT
PY 2016
VL 34
IS 5
BP 398
EP 405
DI 10.1136/acupmed-2016-011112
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EA2WE
UT WOS:000386455700010
PM 27613370
DA 2026-01-16
ER

PT J
AU Wang, CCF
   Tan, JY
   Williams, A
AF Wang, Carol Chunfeng
   Tan, Jing-Yu
   Williams, Anne
TI Safety and side effects of acupuncture therapy in Australia: A
   systematic review
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE Acupuncture; Adverse event; Side effect; Adverse effect; Safety; Risk;
   Systematic review
ID LASER ACUPUNCTURE; CONTROLLED-TRIAL; ADVERSE EVENTS; PAIN; DEPRESSION;
   CANCER
AB Introduction: The tremendous popularity of acupuncture in Australia demands continual safety assessment. This review aimed to determine the characteristics of acupuncture related adverse events, analyse their possible causes, and inform future research and practice.
   Methods: Across 8 databases, all types of clinical trials, surveys, and case reports from 2012 to 2018 reporting adverse events associated with the use of acupuncture in Australia on human subjects were systematically reviewed. Types of acupuncture including manual acupuncture, electro acupuncture and laser acupuncture. Incidence and form of acupuncture related adverse events were the key outcomes of this study. In addition, the quality of adverse events reporting and the likelihood of causality were examined by two reviewers and checked by two experts specialised in acupuncture.
   Results: The 17 analysed studies encompassed ten randomised controlled trials, two nonrandomised controlled trials, three uncontrolled clinical trials, and two case reports, with a total of 1160 participants receiving true acupuncture. Feelings of dizziness, fatigue and nausea were the most common adverse events identified in our review across all acupuncture modalities.
   Conclusions: Acupuncture is generally a safe modality and serious adverse events after treatment are uncommon when supported with well-established guidelines and practiced by licensed, qualified practitioners.
C1 [Wang, Carol Chunfeng] Edith Cowan Univ, Sch Nursing & Midwifery, Perth, WA 6027, Australia.
   [Tan, Jing-Yu] Charles Darwin Univ, Coll Nursing & Midwifery, Darwin, NT 0909, Australia.
   [Williams, Anne] Murdoch Univ, Sch Hlth Profess, Perth, WA, Australia.
C3 Edith Cowan University; Charles Darwin University; Murdoch University
RP Wang, CCF (corresponding author), Edith Cowan Univ, Sch Nursing & Midwifery, Perth, WA 6027, Australia.
EM c.wang@ecu.edu.au; benjamin.tan@cdu.edu.au; anne.williams@murdoch.edu.au
RI Willia, Anne/L-4808-2013; TAN, JINGYU/AAE-5262-2022
OI Willia, Anne/0000-0003-1564-8574; TAN, JINGYU/0000-0002-1609-6890; Wang,
   Carol Chunfeng/0000-0002-6672-7187
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NR 45
TC 10
Z9 11
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD APR
PY 2019
VL 27
BP 81
EP 89
DI 10.1016/j.eujim.2019.03.004
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HW8JZ
UT WOS:000466937000012
DA 2026-01-16
ER

PT J
AU Sand-Jecklin, K
   Reiser, V
AF Sand-Jecklin, Kari
   Reiser, Victoria
TI Use of Seva Stress Release Acupressure to Reduce Pain, Stress, and
   Fatigue in Patients Hospitalized for Cancer Treatment
SO JOURNAL OF HOSPICE & PALLIATIVE NURSING
LA English
DT Article
DE acupressure; complementary and alternative medicine (CAM); fatigue;
   integrative; pain; stress; symptom
ID SYMPTOM CLUSTER; ANXIETY; ACUPUNCTURE; MANAGEMENT; IMPACT
AB Patients undergoing treatment for cancer often experience stress, fatigue, and pain during their treatment. Medical management of these symptoms can cause additional adverse effects, but it is possible that noninvasive complementary therapies may be able to reduce these symptoms without unwanted adverse effects. The purpose of this study was to assess the feasibility and impact of the Seva Stress Release acupressure protocol on stress, fatigue, pain, and vital signs of patients hospitalized for cancer treatment. Thirty patients receiving cancer treatment and experiencing stress, fatigue, and pain were recruited for the study. After obtaining informed consent, baseline data (survey and vital signs) were obtained, followed by administration of the Seva Stress Release. After the intervention, vital signs were obtained, and patients completed 2 additional surveys. After Seva, patient stress, fatigue, pain, heart rate, and respirations were significantly decreased (P = .000). Sixty-six percent of participants experienced symptom relief for at least 1 to 4 hours. Qualitative findings also indicated that patients reported better sleep and mental clarity after the intervention. The Seva protocol could be taught to nurses and be used as an independent intervention for patients experiencing adverse effects of cancer treatment, to promote comfort and reduce stress and fatigue.
C1 [Sand-Jecklin, Kari] West Virginia Univ, Sch Nursing, POB 9640 HSS, Morgantown, WV 26506 USA.
   [Reiser, Victoria] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
C3 West Virginia University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Sand-Jecklin, K (corresponding author), West Virginia Univ, Sch Nursing, POB 9640 HSS, Morgantown, WV 26506 USA.
EM ksandjecklin@hsc.wvu.edu
CR Au DWH, 2015, ACUPUNCT MED, V33, P353, DOI 10.1136/acupmed-2014-010720
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NR 24
TC 2
Z9 3
U1 1
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1522-2179
EI 1539-0705
J9 J HOSP PALLIAT NURS
JI J. Hosp. Palliat. Nurs.
PD DEC
PY 2018
VL 20
IS 6
BP 521
EP 528
DI 10.1097/NJH.0000000000000484
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HA7AM
UT WOS:000450433100005
PM 30379796
DA 2026-01-16
ER

PT J
AU Zhang, JW
   Liu, LY
   Zhu, MJ
   Zheng, XY
   Liang, Y
   Zhong, Y
   Xu, J
   Yang, J
AF Zhang, Jingwen
   Liu, Liying
   Zhu, Manjia
   Zheng, Xiaoyan
   Liang, Yun
   Zhong, Ying
   Xu, Jing
   Yang, Jie
TI Research Status and Prospects of Acupuncture in Perioperative Medicine
   Over the Past Decade: A Bibliometric Analysis
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE acupuncture; perioperative medicine; post-operative; mid-operative;
   CiteSpace; VOSviewer
ID ELECTRICAL ACUPOINT STIMULATION; POSTOPERATIVE PAIN; ENHANCED RECOVERY;
   ELECTROACUPUNCTURE; SURGERY; ANALGESIA; TRENDS; ANESTHESIA; THERAPY;
   CARE
AB Background: Over the past decade, acupuncture in the perioperative period has attracted great interest, and a growing number of related literature has been published.
   Purpose: To analyze the general information and identify the research hotspots and trends of acupuncture in perioperative medicine in the last 10 years by bibliometric analysis.
   Methods: We searched the Web of Science Core Collection for publications on acupuncture in perioperative medicine from 2013 to 2023. The articles and reviews were collected with no language restriction. CiteSpace and VOSviewer software were used for bibliometric and visual analysis of relevant literature.
   Results: A total of 814 bibliographic records were retrieved. Overall, the annual number of publications showed an increasing trend. China and its institutions were in a leading position regarding the publication number. With comparatively more scientific collaboration with China, the USA ranked second. Shanghai University of Traditional Chinese Medicine was the most prolific institution. Ha, In-Hyuk had the most publications, and Han JS and Lee A were the most cited authors. Medicine was the most popular journal and Journal of Clinical Oncology had the highest impact factor. "Acupuncture", "electroacupuncture" and "postoperative pain" were the top three keywords. The most popular topics were postoperative pain, postoperative ileus, and postoperative nausea and vomiting according to the keywords and references. And the clusters of postoperative cognitive dysfunction, anxiety, and breast cancer attracted relatively more attention recently.
   Conclusion: This study summarized the research status, hotspots, and trends of acupuncture in perioperative medicine in the past decade, which may aid researchers in better understanding this field. The research hotspots primarily focused on postoperative pain management and postoperative gastrointestinal function. The research of acupuncture for postoperative cognitive dysfunction, cancer-related surgery, and psychological states were the main frontiers topics and may be the focus in the future.
C1 [Zhang, Jingwen; Liu, Liying; Zheng, Xiaoyan; Liang, Yun; Xu, Jing; Yang, Jie] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
   [Zhu, Manjia] Chengdu Univ Tradit Chinese Med, Basic Med Coll, Chengdu, Sichuan, Peoples R China.
   [Zheng, Xiaoyan; Zhong, Ying; Yang, Jie] Sichuan Jinxin Xinan Womens & Childrens Hosp, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Xu, J; Yang, J (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.; Yang, J (corresponding author), Sichuan Jinxin Xinan Womens & Childrens Hosp, Chengdu, Sichuan, Peoples R China.
EM 195940644@qq.com; jenny_yang_jie@126.com
RI 梁, 云/AGI-1974-2022
FU National Natural Science Foundation of China [82174517]; "Xinglin
   Scholars" Disciplinary Talent Research Promotion Plan Excellent Youth
   Project [YQRC2022001]
FX This research was funded by National Natural Science Foundation of China
   (82174517) and "Xinglin Scholars" Disciplinary Talent Research Promotion
   Plan Excellent Youth Project (YQRC2022001).
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NR 63
TC 7
Z9 7
U1 3
U2 34
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 2189
EP 2204
DI 10.2147/JPR.S415998
PG 16
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA L4US9
UT WOS:001023239200001
PM 37397275
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zeng, JC
   Zhou, RJ
   Luo, ZK
   Zhang, N
   Liu, ZJ
   Lin, GH
AF Zeng, Jingchun
   Zhou, Runjin
   Luo, Zhenke
   Zhang, Na
   Liu, Zijun
   Lin, Guohua
TI Clinical evidence of acupuncture and related therapy in patients with
   cancer-pain A protocol for systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE acupuncture and related therapy; cancer pain; high quality RCTs;
   protocol; protocol; systematic review
ID MANAGEMENT; WOMEN
AB Background: Cancer pain (CP) is one of the common complications of cancer. During the treatment, oral medication, radiotherapy and chemotherapy bring certain adverse reactions to patients with CP; a safe way to treat this disease is necessary. Acupuncture and related therapies for CP with few side effects have been gradually accepted. But at present the evidence is insufficient, the related research is not thorough enough. The purpose of this study was to investigate the efficacy and safety of acupuncture and related therapies for CP. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines were used to design this protocol. The final study will also be conducted under the PRISMA guidelines for systematic reviews and meta-analysis. An electronic search will be conducted in Medline, Embase, and the Cochrane Central Register of Controlled Trials databases through January 2020. The search will be conducted in English. Risk of bias will be assessed by the Cochrane Collaboration tool and the collected evidence will be nar-ratively synthesized. We will also perform a meta-analysis to pool estimates from studies considered to be homogenous. Subgroup analyses will be based on intervention or overall bias. The strength of evidence will be evaluated by the Grading of Recommendations, Assessment, Development and Evaluation scale. Results: This systematic review will summarize high quality clinical evidence to assess and appraise the effectiveness and safety of acupuncture and related therapies for CP patients. Conclusion: The meta-analysis will assess evidence from randomized controlled trials of acupuncture and related therapies and CP types. INPLASY registration number: INPLASY202040129.
C1 [Zeng, Jingchun; Lin, Guohua] Guangzhou Univ Chinese Med, Dept Acupuncture, Affiliated Hosp 1, Guangzhou 510405, Peoples R China.
   [Zhou, Runjin; Luo, Zhenke; Zhang, Na; Liu, Zijun] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zeng, JC; Lin, GH (corresponding author), Guangzhou Univ Chinese Med, Dept Acupuncture, Affiliated Hosp 1, Guangzhou 510405, Peoples R China.
EM tcm_zjc@126.com; tcmlin-801@163.com
OI Lin, Guohua/0000-0002-6656-7726
FU Chinese National Natural Science Foundation [81574061]; Guangdong
   Science and Technology Commission Foundation [2017A020213019];
   Innovative Research Fund of the First Affiliated Hospital of Guangzhou
   University of Chinese Medicine [2019QN23]
FX This work was supported by the Chinese National Natural Science
   Foundation (grant no. 81574061), the Guangdong Science and Technology
   Commission Foundation (No. 2017A020213019) and the Innovative Research
   Fund of the First Affiliated Hospital of Guangzhou University of Chinese
   Medicine (No.2019QN23).
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NR 33
TC 2
Z9 3
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 6
PY 2020
VL 99
IS 45
AR e23119
DI 10.1097/MD.0000000000023119
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OP6AW
UT WOS:000588168200082
PM 33157988
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tang, HY
   Chen, XQ
   Wang, H
   Chu, HR
   Zhu, CF
   Huang, S
   Zhang, MT
   Shen, GM
AF Tang, He-Yong
   Chen, Xi-Qiuyu
   Wang, Hao
   Chu, Hao-Ran
   Zhu, Cai-Feng
   Huang, Shun
   Zhang, Meng-Ting
   Shen, Guo-Ming
TI Acupuncture relieves the visceral pain of diarrhea-predominant irritable
   bowel syndrome rats by regulating P2X4 expression
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE acupuncture; visceral pain; IBS-D rat
ID P2X(7) RECEPTOR; UP-REGULATION; MODEL; GENE; HYPERSENSITIVITY;
   MICROGLIA; ELECTROACUPUNCTURE; SEROTONIN; AGENT; CELLS
AB Objectives: We researched the effect and mechanism of acupuncture treatment for visceral pain in rats with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: We set up a rat model of IBS-D with chemical and chronic-and acute-pressure stimulations. Then, the IBS-D rats were treated with acupuncture or 5-BDBD, and the therapeutic efficacy of acupuncture in IBS-D rats was assessed by means of the Bristol scale, diarrhea index, abdominal withdrawal reflex (AWR) score, mast cell count and histologic staining. Results: Acupuncture significantly decreased clinical symptoms in IBS-D rats after a 14 day-treatment. Furthermore, significant down-regulation of P2X4, OX42, BDNF (brain-derived neurotrophic factor) and IRF-5 (interferon regulatory factor 5) expressions were observed in the IBS-D rats, along with the decreased inflammatory factors [interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6)], chemokines [monocyte chemoattractant protein-1 (MCP-1), regu-lated on activation, normal T cell expressed and secreted (RANTES), and C-X-C motif chemokine ligand 1 (CXCL1)], and neurotransmitters [substance P (SP), 5-hydroxytryptamine (5-HT), and calcitonin gene-related peptide (CGRP)]. 5-BDBD treatment had a similar effect on IBS-D rats. Conclusions: Acupuncture can effectively alleviate abdominal pain by decreasing visceral hypersensitivity and controlling the expression of P2X4 and spinal microglial inflamma-tion in IBS rats.
C1 [Tang, He-Yong; Chen, Xi-Qiuyu; Wang, Hao; Huang, Shun; Zhang, Meng-Ting; Shen, Guo-Ming] Anhui Univ Tradit Chinese Med, Sch Integrated Tradit Chinese & Western Med, Hefei 230012, Anhui, Peoples R China.
   [Chu, Hao-Ran; Zhu, Cai-Feng] Anhui Univ Tradit Chinese Med, Affiliated Hosp 2, Hefei 230012, Anhui, Peoples R China.
   [Shen, Guo-Ming] Anhui Univ Tradit Chinese Med, Sch Integrated Tradit Chinese & Western Med, 1 Qianjiang Rd, Hefei 230012, Anhui, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui University of Chinese
   Medicine; Anhui University of Chinese Medicine
RP Shen, GM (corresponding author), Anhui Univ Tradit Chinese Med, Sch Integrated Tradit Chinese & Western Med, 1 Qianjiang Rd, Hefei 230012, Anhui, Peoples R China.
EM shengm_66@163.com
FU Open fund project acupuncture and Moxibustion Clinical Medicine Research
   Center of Anhui [2021- zjzx07]; Major Research Project of Natural
   Sciences [81973936]; National Natural Science Foundation of China (Youth
   Program) [81904095]
FX The research was funded by the Open fund project acupuncture and
   Moxibustion Clinical Medicine Research Center of Anhui (2021- zjzx07) ,
   the Major Research Project of Natural Sciences (81973936) and National
   Natural Science Foundation of China (Youth Program) (81904095) .
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NR 53
TC 7
Z9 9
U1 1
U2 16
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2022
VL 14
IS 8
BP 5563
EP 5573
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 5A3ZX
UT WOS:000862829300012
PM 36105029
DA 2026-01-16
ER

PT J
AU Franconi, G
   Manni, L
   Schröder, S
   Marchetti, P
   Robinson, N
AF Franconi, Giovanna
   Manni, Luigi
   Schroeder, Sven
   Marchetti, Paolo
   Robinson, Nicola
TI A Systematic Review of Experimental and Clinical Acupuncture in
   Chemotherapy-Induced Peripheral Neuropathy
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID LOW-FREQUENCY ELECTROACUPUNCTURE; SPINAL DORSAL-HORN; MECHANICAL
   ALLODYNIA; NEUROTROPHIC FACTOR; GENE-EXPRESSION; COLD ALLODYNIA;
   MESSENGER-RNA; PAIN; GROWTH; RAT
AB Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect that can be very disabling and can limit or delay the dose of chemotherapy that can be administered. Acupuncture may be effective for treating peripheral neuropathy. The aim of this study was to review the available literature on the use of acupuncture for CIPN. The systematic literature search was performed using MEDLINE, Google Scholar, Cochrane Database, CINHAL, and ISI Proceedings. Hand searching was conducted, and consensus was reached on all extracted data. Only papers in the English language were included, irrespective of study design. From 3989 retrieved papers, 8 relevant papers were identified. One was an experimental study which showed that electroacupuncture suppressed CIPN pain in rats. In addition, there were 7 very heterogeneous clinical studies, 1 controlled randomised study using auricular acupuncture, 2 randomized controlled studies using somatic acupuncture, and 3 case series/case reports which suggested a positive effect of acupuncture in CIPN. Conclusions. Only one controlled randomised study demonstrated that acupuncture may be beneficial for CIPN. All the clinical studies reviewed had important methodological limitations. Further studies with robust methodology are needed to demonstrate the role of acupuncture for treating CIPN resulting from cancer treatment.
C1 [Franconi, Giovanna] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.
   [Manni, Luigi] CNR, Inst Translat Pharmacol, I-00133 Rome, Italy.
   [Schroeder, Sven] Univ Med Ctr Hamburg Eppendorf, HanseMerkur Ctr Tradit Chinese Med, D-20246 Hamburg, Germany.
   [Marchetti, Paolo] Univ Roma La Sapienza, St Andrea Hosp, I-00189 Rome, Italy.
   [Marchetti, Paolo] IDI IRCCS, I-00167 Rome, Italy.
   [Robinson, Nicola] London S Bank Univ, Fac Hlth & Social Care, London SE1 0AA, England.
C3 University of Rome Tor Vergata; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Farmacologia Traslazionale (IFT-CNR); University of
   Hamburg; University Medical Center Hamburg-Eppendorf; Sapienza
   University Rome; Azienda Ospedaliera Sant'Andrea; IRCCS Istituto
   Dermopatico dell'Immacolata (IDI); London South Bank University
RP Franconi, G (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.
EM giovanna.franconi@uniroma2.it
RI Manni, Luigi/J-5637-2018; Marchetti, Paolo/K-1469-2016
OI Schroeder, Sven/0000-0002-8798-9602; Marchetti,
   Paolo/0000-0002-9064-8761; Robinson, Nicola/0000-0001-5256-4527
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NR 62
TC 39
Z9 49
U1 0
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 516916
DI 10.1155/2013/516916
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 194MJ
UT WOS:000322637100001
PM 23983788
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Yildirim, D
   Yildiz, CC
AF Yildirim, Dilek
   Yildiz, Cennet Ciris
TI The effect of acupressure on vital signs, acute pain, stress and
   satisfaction during venipuncture: Single-blind, randomized controlled
   study
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Acupressure; Vital signs; Acute pain; Stress; Satisfaction;
   Venipuncture; Randomized controlled trial
ID ACUPUNCTURE; ANXIETY; CANCER; POINT
AB Introduction: Pain increases the patient's anxiety levels and prolongs examination and other medical processes. This study was conducted as a single-blind, randomized controlled study to determine the effects of acupressure applied on adult patients and whether it changed their vital signs, acute pain, stress and satisfaction during venipuncture.
   Methods: Patients who had a BMI of 18.5-30 kg/m(2), presence of an internal disease, were attending a routine clinic check-up, had requested to have a blood sample, were examined by a physician, had no sign of pain, hematoma, necrosis, scar, incision or infection on the skin around the venipuncture site and had taken no analgesic drug for the last six hours were included in the trial. Patients were randomly allocated to either an acupressure group (n=100) or a no-intervention control group (n=100). Acupressure (LI 4, LI 11 and HT 7 points) was applied once by a certified researcher for 10 min prior to venipuncture. Pain, satisfaction, stress, heart rate and oxygen saturation levels of the patients in the acupressure and control groups were assessed 15 min before and immediately after the venipuncture procedure. The Visual Analog Scale for the Measurement of Pain Severity, the Visual Analog Patient Satisfaction Scale and the State-Trait Anxiety Inventory were used to collect the data.
   Results: The acupressure group had a significantly lower mean pain score than the control group (respectively, 1.23 +/- 1.09 and 1.95 +/- 1.95, p<0.05). The acupressure group had a significantly higher mean satisfaction score than the control group (respectively, 9.13 +/- 1.31 and 8.51 +/- 1.86, p<0.05). The acupressure group had a significantly lower mean stress score than the control group (respectively, 34.66 +/- 7.99 and 41.91 +/- 9.21, p<0.05).
   Conclusion: Acupressure reduced acute pain and stress and increased satisfaction levels in adult patients undergoing venipuncture.
C1 [Yildirim, Dilek] Istanbul Aydin Univ, Fac Hlth Sci, Dept Nursing, Istanbul, Turkey.
   [Yildiz, Cennet Ciris] Istanbul Kent Univ, Fac Hlth Sci, Dept Nursing, Istanbul, Turkey.
C3 Istanbul Aydin University; Istanbul Kent University
RP Yildirim, D (corresponding author), Florya Campus,Halit Aydin Campus,Inonu St 38, TR-34295 Kucukcekmece Istanbul, Turkey.
EM dilekaticiyildirim@gmail.com; cennetciris.yildiz@kent.edu.tr
RI çiriş yıldız, cennet/AGS-5290-2022; Yildirim, Dilek/AAV-2960-2021
OI çiriş yıldız, cennet/0000-0002-1351-5439; Yildirim,
   Dilek/0000-0002-6228-0007
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NR 40
TC 15
Z9 16
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD JUN
PY 2021
VL 44
AR 101343
DI 10.1016/j.eujim.2021.101343
EA JUN 2021
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA SQ6NH
UT WOS:000660469600007
DA 2026-01-16
ER

PT J
AU Ranieri, G
   Laface, C
   Fazio, V
   De Ceglia, D
   Macina, F
   Gisone, V
   Porcelli, M
   Vinciarelli, G
   Carella, C
   Molinari, P
   Laricchia, G
   Laforgia, M
   Cosmo, DG
AF Ranieri, G.
   Laface, C.
   Fazio, V
   De Ceglia, D.
   Macina, F.
   Gisone, V
   Porcelli, M.
   Vinciarelli, G.
   Carella, C.
   Molinari, P.
   Laricchia, G.
   Laforgia, M.
   Cosmo, D. Gadaleta
TI Local treatment with deep percutaneous electrochemotherapy of different
   tumor lesions: pain relief and objective response results from an
   observational study
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Deep percutaneous electrochemotherapy; Pain relief; Local disease
   control; Adrenal metastasis; Malignant pleural mesothelioma; Uterine
   leiomyosarcoma; Male mUllerian tumor
ID STANDARD OPERATING PROCEDURES; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA;
   RADIOFREQUENCY ABLATION; ANTITUMOR EFFECTIVENESS; EUROPEAN RESEARCH;
   METASTASES; HEAD; ELECTROPORATION; RECURRENCE
AB OBJECTIVE: The aim of this investigation focuses on the evaluation of the efficacy of deep-seated Electrochemotherapy (ECT) in terms of pain relief and local objective response. in pre-treated patients with neither further available pharmacological treatments nor eligible for surgery.
   PATIENTS AND METHODS: Deep percutaneous ECT has been performed in 20 patients subjected to systemic anaesthesia. Bleomycin was administrated intravenously before the application of the electrical pulses on the target area, employing multiple single needles depending on the size and location of the target tumor.
   RESULTS: Pain assessment based on Visual Analogue Scale showed significant pain relief one month after treatment in all patients, reducing from 7.5 to 3 as a median value (p-value at Wilcoxon test <0.001). Local symptom-free survival median value was 5.5 months. At the first follow-up (1-2 months), a local disease control rate (LDCR) was observed in 19/20 (95%) patients: complete responses in 2 (10%), partial responses in 8 (40%) and stable disease in 9 (45%). Local progression-free survival median value was 5.7 months. Overall, no major adverse effects were observed.
   CONCLUSIONS: Our study indicates that deep percutaneous ECT can produce a significant pain reduction and a high LDCR in different tumor lesions, for anatomical site or histotype. In particular, ECT has demonstrated to be effective in various histotypes and deep-seated tumor lesions never treated before by this approach giving a new chance to physicians for reducing oncological pain in patients not eligible to other therapeutic routes. The innovative peculiarity of our study was the successful application of deep percutaneous ECT on adrenal metastasis, malignant pleural mesothelioma, uterine leiomyosarcoma and the uncommon case of a male mullerian tumor.
C1 [Ranieri, G.] IRCCS Ist Tumori G Paolo II, Intervent & Med Oncol Unit, Bari, Italy.
   IRCCS Ist Tumori G Paolo II, Pharm Unit, Bari, Italy.
RP Ranieri, G (corresponding author), IRCCS Ist Tumori G Paolo II, Intervent & Med Oncol Unit, Bari, Italy.
EM giroran@tiscali.it
RI Molinari, Pasquale/JCE-5412-2023; Vinciarelli, Gianluca/AAG-8698-2021;
   Laricchia, Giuseppe/AAR-2646-2020; Laface, Carmelo/AAO-2914-2021
OI Molinari, Pasquale/0000-0002-6335-7993; Gisone,
   Vito/0000-0002-7701-6735; Laface, Carmelo/0000-0002-5074-4951
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NR 47
TC 11
Z9 13
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2020
VL 24
IS 14
BP 7764
EP 7775
DI 10.26355/eurrev_202007_22279
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MU7XP
UT WOS:000555882500021
PM 32744703
DA 2026-01-16
ER

PT J
AU Yang, J
   Xu, GX
   Yin, ZH
   Cheng, Y
   Sun, SM
   Zheng, QH
   Chen, J
   Liang, FR
   Zhao, L
AF Yang, Jiao
   Xu, Guixing
   Yin, Zihan
   Cheng, Ying
   Sun, Sheng Ming
   Zheng, Qianhua
   Chen, Jiao
   Liang, Fan-rong
   Zhao, Ling
TI Acupuncture for chronic cancer-related pain: a systematic review and
   network meta-analysis protocol
SO BMJ OPEN
LA English
DT Review
DE anaesthesia in oncology; complementary medicine; pain management
ID MULTIPLE-TREATMENTS; BREAST-CANCER; QUALITY; PREVALENCE; PREDICTORS;
   MANAGEMENT
AB Introduction Chronic cancer-related pain is one of the most common excruciating symptom that can be caused by the cancer (by the primary tumour or by metastases) or by its treatment (surgery, chemotherapy and radiotherapy). Although multiple clinical trials and systematic reviews have suggested that acupuncture could be effective in treating chronic cancer-related pain, the comparative efficacy and safety of these acupuncture methods remains unclear. We, therefore, performed this study to evaluate and rank the efficacy and safety of different acupuncture methods for chronic cancer-related pain. Methods and analysis Seven databases will be searched, including Cochrane Library, MEDLINE, Embase, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, the Chongqing VIP Chinese Science and Technology Periodical Database and Chinese Biomedical Literature Database (CBM) from their inception to March 2020. The primary outcome is the change of pain intensity. Bayesian network meta-analysis will be conducted using software R3.5.1. Finally, we will use the Grading of Recommendations Assessment, Development and Evaluation System (GRADE) to assess the quality of evidence. Ethics and dissemination Ethical approval is not required for literature-based studies. The results will be disseminated through peer-reviewed publication. PROSPERO registration number CRD42020165747
C1 [Yang, Jiao; Xu, Guixing; Yin, Zihan; Cheng, Ying; Sun, Sheng Ming; Zheng, Qianhua; Chen, Jiao; Liang, Fan-rong; Zhao, Ling] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Liang, FR; Zhao, L (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
EM acuresearch@126.com; zhaoling@cdutcm.edu.cn
RI CHEN, JIAO/GZA-5784-2022
OI Yin, Zihan/0000-0001-8741-1205; Cheng, Ying/0000-0003-3377-171X
FU National Key Research and Development Program [2019YFC1709701]; National
   Natural Science Foundation of China [81590951, 81973962]; Project of
   Science and Technology Department of Sichuan Province [20ZDYF1199,
   2019YFS0081]
FX This work was financially supported by the National Key Research and
   Development Program (NO.2019YFC1709701), the National Natural Science
   Foundation of China (No. 81590951, 81973962) and the Project of Science
   and Technology Department of Sichuan Province (No. 20ZDYF1199,
   2019YFS0081).
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NR 45
TC 1
Z9 2
U1 0
U2 17
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 10
AR e039087
DI 10.1136/bmjopen-2020-039087
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OI5DD
UT WOS:000583298100015
PM 33033027
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Li, XM
   Zhu, JH
   Li, PP
   Zhu, GQ
   Wu, XM
   Chen, HM
   Zhao, HX
   Wang, W
   Zhang, Y
   Xiao, WH
   Liu, DQ
AF Li, Xiaomei
   Zhu, Jianhua
   Li, Pingping
   Zhu, Guangqing
   Wu, Xiaoming
   Chen, Huoming
   Zhao, Huixia
   Wang, Wei
   Zhang, Ying
   Xiao, Wenhua
   Liu, Duanqi
TI A preliminary report on adjuvant analgesic efficacy of HANS in opioid
   tolerant patients with cancer pain
SO CHINESE JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE Cancer pain; opioid tolerance; Han's Acupoint Nerve Stimulator (HANS)
ID ELECTRICAL NERVE-STIMULATION; QUALITY-OF-LIFE; CHINESE VERSION; EORTC
   QLQ-C30; ELECTROACUPUNCTURE; OUTPATIENTS; RECEPTORS; ONCOLOGY;
   REQUIREMENT; VALIDATION
AB Objective: To observe the adjuvant analgesic efficacy of Han's Acupoint Nerve Stimulator (HANS) in opioid tolerant patients with cancer pain.
   Methods: A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS (2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks). Cancer pain, quality of life (QOL), anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale (SAS)/self-rating depression scale (SDS), respectively; the therapeutic frequency of breakthrough pain (BP) and daily opioid dose were also recorded.
   Results: Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient's "worst" and "least" pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine 'symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15.
   Conclusions: To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients' QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.
C1 [Li, Xiaomei; Zhu, Jianhua; Zhao, Huixia; Xiao, Wenhua] Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Med Oncol, Beijing 100048, Peoples R China.
   [Li, Xiaomei; Liu, Duanqi] Beijing Army Gen Hosp, Expert Grp, Dept Cadre Ward 3, Beijing 100700, Peoples R China.
   [Li, Pingping; Wang, Wei; Zhang, Ying] Peking Univ, Canc Hosp & Inst, Dept Integrated Tradit Chinese & Western Med, Key Lab Carcinogenesis & Tradit Res,Minist Educ, Beijing 100142, Peoples R China.
   [Zhu, Guangqing] Chinese PLA, Gen Hosp Air Force, Dept Med Oncol, Beijing 100142, Peoples R China.
   [Wu, Xiaoming] Chinese Acad Med Sci, Canc Inst & Hosp, Integrated Dept, Beijing 100021, Peoples R China.
   [Chen, Huoming] Second Artillery Gen Hosp, Dept Med Oncol, Beijing 100088, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Peking University;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Cancer Institute & Hospital - CAMS
RP Xiao, WH (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Med Oncol, Beijing 100048, Peoples R China.
EM w_hxiao@hotmail.com
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NR 29
TC 4
Z9 6
U1 0
U2 10
PU CHINESE JOURNAL CANCER RESEARCH CO
PI BEIJING
PA LTD PEKING U CANCER HOSP & INST, NO 52, FUCHENG RD, HAIDIAN, BEIJING,
   100142, PEOPLES R CHINA
SN 1000-9604
EI 1993-0631
J9 CHINESE J CANCER RES
JI Chin. J. Cancer Res.
PD APR
PY 2014
VL 26
IS 2
BP 174
EP 182
DI 10.3978/j.issn.1000-9604.2014.04.02
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AG7TR
UT WOS:000335622200008
PM 24826058
DA 2026-01-16
ER

PT J
AU Li, Z
   Gao, Y
   Yan, D
   Feng, YH
AF Li, Zhe
   Gao, Yu
   Yan, Dong
   Feng, Yi-Hui
TI Efficacy of electroacupuncture for cervical spondylosis-related pain in
   patients with generalized anxiety disorder
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Electroacupuncture; Cervical spondylosis; Generalized anxiety disorder;
   Neuroinflammation; Pain management
ID ACUPUNCTURE; OSTEOARTHRITIS; KNEE
AB BACKGROUND Cervical spondylosis (CS) frequently co-occurs with generalized anxiety disorder (GAD), presenting a complex clinical challenge. Managing CS-related pain in patients with GAD is particularly challenging because of the bidirectional relationship between pain and anxiety, necessitating integrated treatment strategies. AIM To evaluate the efficacy of electroacupuncture (EA) in treating CS-related pain and anxiety in patients with GAD. METHODS This retrospective cohort study analyzed data from 83 patients with CS-related pain and GAD who received EA treatment over 2-year period. Pain intensity was assessed using the visual analog scale, and anxiety symptoms were measured using the Hamilton Anxiety Rating Scale. Additionally, neuroinflammatory markers, including interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein, were examined. Outcomes were evaluated at baseline, after 4 weeks, and after 8 weeks of treatment. RESULTS EA treatment significantly reduced CS-related pain (mean visual analog scale reduction: 3.24 +/- 1.18; P < 0.001) and improved anxiety symptoms (mean Hamilton Anxiety Rating Scale reduction: 7.83 +/- 2.65; P < 0.001) after 8 weeks of treatment. Neuroinflammatory markers also showed significant reductions, with interleukin-6 and tumor necrosis factor-alpha levels decreasing by 32.7% and 28.5%, respectively (P < 0.01). Pain reduction was significantly correlated with improvements in anxiety symptoms (r = 0.68; P < 0.001) and a decrease in inflammatory markers (r = 0.54; P < 0.01). CONCLUSION EA demonstrates significant efficacy in reducing CS-related pain in patients with comorbid GAD, along with concurrent improvements in anxiety symptoms and neuroinflammatory profiles. These findings suggest that EA may offer a valuable integrative approach for managing this complex clinical presentation, potentially addressing both pain and anxiety through the modulation of neuroinflammatory pathways.
C1 [Li, Zhe] Zhengzhou Orthopaed Hosp, Dept Pain Dis Treatment, Zhengzhou 450052, Henan, Peoples R China.
   [Gao, Yu; Yan, Dong] Zhengzhou Orthopaed Hosp, Dept Cervicolumbar, Zhengzhou 450052, Henan, Peoples R China.
   [Feng, Yi-Hui] Univ Hlth & Rehabil Sci, Dept Acupuncture & Moxibust, 369 Dengyun Rd, Qingdao 266042, Shandong, Peoples R China.
C3 University of Health & Rehabilitation Sciences
RP Feng, YH (corresponding author), Univ Hlth & Rehabil Sci, Dept Acupuncture & Moxibust, 369 Dengyun Rd, Qingdao 266042, Shandong, Peoples R China.
EM walgzzh@126.com
RI FENG, YIHUI/M-6931-2017
CR Araya-Quintanilla F, 2022, J BODYW MOV THER, V29, P117, DOI 10.1016/j.jbmt.2021.10.012
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD NOV 19
PY 2025
VL 15
IS 11
AR 108288
DI 10.5498/wjp.v15.i11.108288
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA C0345
UT WOS:001620120100015
PM 41281520
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Zhao, Y
   Cao, WD
   Zhang, HH
   Rong, QX
   He, MX
   Wu, MJ
   Zhao, Y
   Yang, P
AF Zhao, Yi
   Cao, Wendi
   Zhang, Hengheng
   Rong, Qingxi
   He, Mingxuan
   Wu, Meijie
   Zhao, Yi
   Yang, Ping
TI The efficacy of acupuncture in the treatment of chemotherapy-induced
   peripheral neuropathy in cancer patients: a systematic review and
   meta-analysis
SO JOURNAL OF CANCER SURVIVORSHIP
LA English
DT Review; Early Access
DE Acupuncture; Peripheral nervous system diseases; Cancer supportive care;
   Systematic review; Meta-analysis
ID ELECTROACUPUNCTURE; PREVENTION; MECHANISMS; ANALGESIA; QUALITY; TRIALS
AB PurposeChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in cancer patients, often emerging within the first month of chemotherapy. Severe CIPN can disrupt daily life, necessitating chemotherapy adjustments or discontinuation, which may increase cancer mortality. No standardized treatment exists, but acupuncture is widely used in China for CIPN.This study aimed to comprehensively assess the actual efficacy of acupuncture in treating CIPN in cancer patients.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane Library up to October 2024 for randomized controlled trials (RCTs) on acupuncture for CIPN, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Methodological quality was assessed using the Cochrane risk-of-bias tool (RoB 2.0) and the modified Jadad scale. A random-effects model was used to analyze the Effect Size (ES) and 95% Confidence Interval (CI).Data analysis was performed using RevMan 5.3 software.ResultsThe final analysis incorporated 1,048 patients from 18 studies. The results presented in the forest plot demonstrated that, when compared to the control group, acupuncture exhibited superior efficacy in improving CIPN symptoms (RR = 1.11, 95%CI [1.01,1.21]), alleviating pain (SMD = -0.93, 95%CI [-1.63,-0.22]), enhancing quality of life (QoL) (MD = - 1.14, 95%CI [- 1.97, - 0.31]), and reducing chemotherapy-related neurotoxicity (MD = - 3.34, 95%CI [- 5.24, - 1.44]). Additionally, in alleviating CIPN-related pain, simple acupuncture demonstrates superior efficacy compared to electroacupuncture.ConclusionThis study clearly demonstrates that acupuncture offers more substantial benefits to CIPN patients compared to usual care, medication, vitamin, and sham acupuncture. This research serves as a valuable reference for cancer patients, physicians, nurses, and other professional medical practitioners.
C1 [Zhao, Yi; Cao, Wendi; Zhang, Hengheng; Rong, Qingxi; He, Mingxuan; Wu, Meijie; Zhao, Yi; Yang, Ping] Qinghai Univ, Breast Dis Diag & Treatment Ctr, Affiliated Hosp, Xining 810000, Peoples R China.
   [Zhao, Yi; Cao, Wendi; Zhang, Hengheng; Rong, Qingxi; He, Mingxuan; Wu, Meijie; Zhao, Yi; Yang, Ping] Qinghai Univ, Affiliated Canc Hosp, Xining 810000, Peoples R China.
C3 Qinghai University; Qinghai University
RP Zhao, Y; Yang, P (corresponding author), Qinghai Univ, Breast Dis Diag & Treatment Ctr, Affiliated Hosp, Xining 810000, Peoples R China.; Zhao, Y; Yang, P (corresponding author), Qinghai Univ, Affiliated Canc Hosp, Xining 810000, Peoples R China.
EM zywm0001@163.com; 1290912204@qq.com
CR American Cancer Chemotherapy Society, 2022, The role and significance of chemotherapy in cancer management
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NR 61
TC 1
Z9 1
U1 6
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1932-2259
EI 1932-2267
J9 J CANCER SURVIV
JI J. Cancer Surviv.-Res. Pract.
PD 2025 AUG 19
PY 2025
DI 10.1007/s11764-025-01869-3
EA AUG 2025
PG 13
WC Oncology; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Biomedical Social Sciences
GA 6GF9B
UT WOS:001552622700001
PM 40830723
DA 2026-01-16
ER

PT J
AU Ruan, AM
   Wang, QF
   Ma, YF
   Zhang, D
   Yang, LL
   Wang, ZP
   Xie, Q
   Yin, YS
AF Ruan, Anmin
   Wang, Qingfu
   Ma, Yufeng
   Zhang, Dong
   Yang, Lili
   Wang, Zhongpeng
   Xie, Qi
   Yin, Yueshan
TI Efficacy and Mechanism of Electroacupuncture Treatment of Rabbits With
   Different Degrees of Knee Osteoarthritis: A Study Based on Synovial
   Innate Immune Response
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE electro-acupuncture; knee osteoarthritis; innate immune response;
   signaling pathway; mechanism research
ID ARTICULAR-CARTILAGE; PAIN; INFLAMMATION; ACUPUNCTURE; ARTHRITIS; WEIGHT;
   SYSTEM; MODEL; RISK
AB Knee osteoarthritis (KOA) is a chronic degenerative bone and joint disease, which is often clinically manifested as pain, joint swelling, and deformity. Its pathological manifestations are mainly synovial inflammation and cartilage degeneration. This study aims to investigate the efficacy of electro-acupuncture (EA) on model rabbits with varying degrees of KOA and to study the mechanism of EA on KOA based on the innate immune response. Mild and moderate rabbit KOA models were established using a modified Hluth method, and EA was given to both the mild and moderate model groups. The Lequesne-MG index was used to evaluate the behavioral changes in the rabbits before and after EA treatment. Morphological changes in the synovial membrane and cartilage of each group were observed by H&E staining. The Mankin scoring standard and the Krenn scoring standard were used to score the pathology of the cartilage tissue and synovial tissue, respectively. The inflammatory factors and metalloproteinases were detected in the serum of each group by ELISA. The protein and messenger RNA (mRNA) expressions of important elements related to Toll-like receptors (TLRs)-mediated innate immune response in the synovial tissue were detected by Western blot and quantitative PCR (qPCR). The Lequesne-MG index score of the rabbits gradually increased with the modeling prolonged but decreased significantly after EA treatment, indicating that EA has a better effect on alleviating the pain and improving the dysfunction. The morphological analysis showed that the inflammation of and the damage to the synovial membrane and the cartilage tissue gradually deteriorated with the modeling prolonged. However, the synovial membrane inflammation was significantly relieved after EA treatment, and the cartilage injury showed signs of repair. The ELISA analysis showed that, with the modeling prolonged, the serum-related inflammatory factors and mechanism of metalloproteinases gradually increased but decreased after EA treatment. The tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and matrix metalloproteinase3 (MMP3) of EA1 group were significantly lower than those of EA2 group. Both Western blot and qPCR results showed that the protein and mRNA expressions of the elements related to the innate immune response in the synovial membrane increased gradually with the modeling prolonged, but decreased significantly after EA treatment. Additionally, the expression of some components in EA1 group was significantly lower than that in EA2 group. These results confirm that synovial inflammation gradually aggravated with time from the early to mid-stage of KOA. EA alleviated the inflammation and histological changes in KOA rabbits by inhibiting the TLRs-mediated innate synovial immune response. This suggests that using EA in the early stage of KOA may achieve a desirable efficacy.
C1 [Ruan, Anmin; Yang, Lili] Beijing Longfu Hosp, Dept Orthoped, Beijing, Peoples R China.
   [Wang, Qingfu; Ma, Yufeng] Beijing Univ Chinese Med, Dept Tendon & Injury, Hosp 3, Beijing, Peoples R China.
   [Zhang, Dong] Beijing Univ Chinese Med, Dept Gen Surg, Hosp 2, Beijing, Peoples R China.
   [Wang, Zhongpeng; Yin, Yueshan] Beijing Univ Chinese Med, Acupuncture & Moxibust Dept, Hosp 3, Beijing, Peoples R China.
   [Xie, Qi] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine
RP Yin, YS (corresponding author), Beijing Univ Chinese Med, Acupuncture & Moxibust Dept, Hosp 3, Beijing, Peoples R China.
EM yinyueshan1984@163.com
FU School-level Young Teachers Project of Beijing University of Chinese
   Medicine [2018-JYBZZJS199]
FX This project was supported by School-level Young Teachers Project of
   Beijing University of Chinese Medicine (2018-JYBZZJS199).
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NR 34
TC 19
Z9 23
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 5
PY 2021
VL 12
AR 642178
DI 10.3389/fphys.2021.642178
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA UD2NP
UT WOS:000687049600001
PM 34421630
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Thottungal, A
   Kumar, P
   Bhaskar, A
AF Thottungal, Athmaja
   Kumar, Pranab
   Bhaskar, Arun
TI Interventions for myofascial pain syndrome in cancer pain: recent
   advances: why, when, where and how
SO CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
LA English
DT Review
DE cancer pain; myofascial pain syndrome; myofascial trigger points;
   trigger point injection; ultrasound
ID GUIDED TRIGGER-POINT; BREAST-CANCER; MUSCLE; MANAGEMENT; INJECTION;
   ACUPUNCTURE; PREVALENCE; MECHANISMS; DIAGNOSIS; MEDICINE
AB Purpose of review
   Pain is one of the most feared and most common symptoms of cancer, experienced by 38-85% of patients. Pain in terminally ill cancer patients is a multidimensional experience caused by a diverse array of factors - cancer itself, its treatment or other causes. Studies have shown a high incidence of myofascial pain syndrome (MPS) in patients with cancer and the knowledge of myofascial trigger points (MTrPs) is important to address and manage existing pain, and to prevent the recurrence of pain. This review aims to summarize recent advances in interventions for managing MPS in patients with cancer.
   Recent findings
   Database searches were conducted on MEDLINE, CINAHL, and Google Scholar to locate all studies published from inception until April 2019 using the keywords cancer pain, myofascial pain, TrPs with emphasis of any methodological quality that included interventions for MPS. MPS in advanced cancer patients are more commonly observed along with other cancer pains rather than independently with a prevalence of 11.9-48% in those patients diagnosed with cancer of head and neck and breast cancer.
   Summary
   Interventional therapies employing ultrasound guided injection of the MTrPs is gaining popularity in the management of MPS in cancer pain and may be a better alternative than the use of opioid analgesics in the multidisciplinary management.
C1 [Thottungal, Athmaja] East Kent Univ Hosp, Dept Anesthesia & Pain Management, Canterbury, Kent, England.
   [Kumar, Pranab] Toronto Western Hosp, Univ Hlth Network, Dept Anesthesia & Pain Management, Toronto, ON, Canada.
   [Bhaskar, Arun] Charing Cross Univ Hosp, Dept Anesthesia & Pain Management, London, England.
C3 University of Toronto; University Health Network Toronto
RP Bhaskar, A (corresponding author), Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Management Ctr, 2nd Floor South,Fulham Palace Rd, London W6 8RF, England.
EM akbhaskar@btinternet.com
RI Kumar, Pranab/AIE-9445-2022
OI Thottungal, Athmaja/0000-0003-4975-4287
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NR 60
TC 15
Z9 18
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1751-4258
EI 1751-4266
J9 CURR OPIN SUPPORT PA
JI Curr. Opin Support Palliat. Car.
PD SEP
PY 2019
VL 13
IS 3
BP 262
EP 269
DI 10.1097/SPC.0000000000000446
PG 8
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA JV0DK
UT WOS:000502036700018
PM 31348012
DA 2026-01-16
ER

PT J
AU Serçe, S
   Ovayolu, Ö
   Pirbudak, L
   Ovayolu, N
AF Serce, Sibel
   Ovayolu, Ozlem
   Pirbudak, Lutfiye
   Ovayolu, Nimet
TI The Effect of Acupressure on Pain in Cancer Patients With Bone
   Metastasis: A Nonrandomized Controlled Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE cancer; pain; metastasis; radiotherapy; acupressure; nursing
ID QUALITY-OF-LIFE; SYMPTOM MANAGEMENT; ANALGESIA; MYELOMA; BREAST
AB Background: Pain is a serious and common problem in bone metastases. For this purpose, complementary and supportive practices are also applied along with medical treatment. This study was conducted for the purpose of evaluating the effect of acupressure on pain in cancer patients with bone metastasis. Methods: The study was conducted in a nonrandomized controlled trial with patients who applied to the radiotherapy unit of an oncology hospital. The data of the study were collected by using a questionnaire and the Visual Analog Scale. A total of 8 acupressure sessions, which lasted for approximately 10 minutes each (with warming and acupressure periods), was applied to the intervention group. The data were analyzed by using (2) test, paired t test, and Pearson's correlation coefficient. Results: It was determined that the pain mean score of the intervention group was 7.6 +/- 1.9 before the acupressure and decreased to 6.8 +/- 1.9 after the acupressure and this result was statistically significant. On the other hand, no significant difference was determined in the pain mean score of the control group. Conclusions: Acupressure is applicable for cancer patients with bone metastasis by nursing staff after receiving brief training and may make a difference in relieving pain of the patients. Further well-designed trials should be conducted.
C1 [Serce, Sibel] Gaziantep Univ Hosp, Gaziantep, Turkey.
   [Ovayolu, Ozlem; Ovayolu, Nimet] Gaziantep Univ, Dept Nursing, Fac Hlth Sci, TR-27310 Gaziantep, Turkey.
   [Pirbudak, Lutfiye] Gaziantep Univ, Sch Med, Gaziantep, Turkey.
C3 Gaziantep University; Gaziantep University; Gaziantep University
RP Ovayolu, Ö (corresponding author), Gaziantep Univ, Dept Nursing, Fac Hlth Sci, TR-27310 Gaziantep, Turkey.
EM oucan@gantep.edu.tr
RI Pirbudak, Lutfiye/AAG-6600-2020; Ovayolu, Ozlem/AAG-5541-2020
OI Ovayolu, Ozlem/0000-0002-7335-4032
CR Ayceman N., Akupresur-Shiatsu Course Note, Health and Natural Therapies Association, Antalya [in Turkish]
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NR 30
TC 15
Z9 17
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2018
VL 17
IS 3
BP 728
EP 736
DI 10.1177/1534735418769153
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA GQ8BY
UT WOS:000441976400015
PM 29649905
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huong, HTX
   Alex, M
   Wan, CC
   Anh, VH
   Phuc, BT
AF Huong, Hoang Thi Xuan
   Alex, Molassiotis
   Wan, Chan Choi
   Anh, Vu Hoang
   Phuc, Bui Thanh
TI Pilot randomized sham-controlled trial of self-acupressure to manage the
   symptom cluster of insomnia, depression, and anxiety in cancer patients
   undergoing chemotherapy
SO SLEEP AND BREATHING
LA English
DT Article
DE Symptom cluster; Insomnia; Cancer; Trial; Acupressure; Anxiety;
   Depression; Sleep
ID AURICULAR POINT ACUPRESSURE; SLEEP DISTURBANCES; HOSPITAL ANXIETY;
   SEVERITY INDEX; FATIGUE; ACUPUNCTURE; QUALITY; SCALE; PAIN
AB Purpose Current evidence for using self-acupressure to manage the cancer-related symptom cluster of insomnia, depression, and anxiety, while promising, is unknown. This study evaluated the feasibility of self-acupressure to manage this symptom cluster and to explore its potential effectiveness.
   Methods Participants were assigned randomly to three study groups, namely the true acupressure (TAP), the sham acupressure (SAP), and the enhanced standard care group (ESC). Participants in the TAP and SAP groups received a training session on acupressure and were required to practice self-acupressure at home once per day for 28 days. The duration of participant involvement was 8 weeks. Patients completed a Numerical Rating Scale (NRS) for each symptom, the Insomnia Severity Index, the Hospital Anxiety and Depression Scale, and the Functional Assessment of Cancer Therapy-General at baseline (T1), post-intervention (T2, week 4), and post follow-up (T3, week 8).
   Results The results indicated that the intervention had clinical significance in improving the targeted symptoms and quality of life. In the TAP group, the symptom cluster severity was significantly lower than in the other groups at T2 (p < 0.05). The insomnia severity and anxiety scores in the TAP and SAP groups were significantly lower than those in ESC at T2 and T3 (p < 0.05).
   Conclusion The trial was feasible. The promising results of the study suggest that further testing of self-acupressure is warranted to inform its effectiveness on the targeted symptom cluster in patients with cancer. A placebo effect was evident alongside therapeutic effects.
C1 [Huong, Hoang Thi Xuan; Alex, Molassiotis; Wan, Chan Choi] Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Kowloon, 11 Yuk Choi Rd, Hong Kong, Peoples R China.
   [Huong, Hoang Thi Xuan; Anh, Vu Hoang] Phenikaa Univ, Fac Nursing, Hanoi, Vietnam.
   [Phuc, Bui Thanh] Vietnam Germany Univ Hosp, Hanoi, Vietnam.
   Vietnam Natl Canc Hosp, 43 Quan St, Hanoi, Vietnam.
   Hanoi Oncol Hosp, 42A Thanh Nhan, Hanoi, Vietnam.
C3 Hong Kong Polytechnic University; Vietnamese-German University
RP Huong, HTX (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Kowloon, 11 Yuk Choi Rd, Hong Kong, Peoples R China.; Huong, HTX (corresponding author), Phenikaa Univ, Fac Nursing, Hanoi, Vietnam.
EM xuan-huong.hoangthi@connect.polyu.hk
RI Molassiotis, Alex/MDS-6695-2025
OI Molassiotis, Alex/0000-0001-6351-9991
FU Hong Kong Polytechnic University, Hong Kong SAR; Phenikaa University,
   Hanoi, Vietnam [07-2019.03]
FX This work was supported by The Hong Kong Polytechnic University, Hong
   Kong SAR under a research student grant and the Phenikaa University,
   Hanoi, Vietnam under grant 07-2019.03.
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NR 43
TC 22
Z9 24
U1 4
U2 26
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAR
PY 2022
VL 26
IS 1
BP 445
EP 456
DI 10.1007/s11325-021-02370-8
EA APR 2021
PG 12
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Respiratory System
GA ZC9SF
UT WOS:000640153700002
PM 33855642
DA 2026-01-16
ER

PT J
AU Cáceres-Matos, R
   Vázquez-Santiago, S
   Pabón-Carrasco, M
   Cabrera-León, A
   Gil-García, E
AF Caceres-Matos, Rocio
   Vazquez-Santiago, Soledad
   Pabon-Carrasco, Manuel
   Cabrera-Leon, Andres
   Gil-Garcia, Eugenia
TI Understanding the Impact of Chronic Non-Cancer Pain on Daily Life from a
   Gender Perspective Using the PAIN_Integral Scale©
SO HEALTHCARE
LA English
DT Article
DE chronic pain; factor analysis; statistical; female; male; surveys and
   questionnaires; validation
ID SEX-DIFFERENCES; FIT INDEXES; INVARIANCE; HEALTH; PREVALENCE; WOMEN;
   MEN; ILLNESS; ADULTS; RISK
AB The experience of chronic non-cancer pain differs between women and men due to gender-related factors. This study (1) assessed the difference in responses to the impact of chronic non-cancer pain on daily life in women and men using the PAIN_Integral Scale (c) and (2) evaluated its invariance through multigroup confirmatory factor analysis. This was conducted by means of an analysis of invariance through a multigroup confirmatory factor analysis. A cross-sectional sample of 400 participants over 18 years of age with Chronic Non-Oncological Pain in Pain Units and Primary Care Centres belonging to the Spanish Public Health System was recruited (January to March 2020). An analysis was performed to assess whether any of the items in the instrument showed different behaviours. All analyses were performed using AMOS (R) v.26 software. The results showed that the structure of the PAIN_Integral (c) Scale remained adequate when analysing its invariance in women and men, showing no metric, scalar and/or strict invariance. Therefore, these results indicated that the PAIN_Integral Scale (c) instrument has a different interpretation for women and men, identifying eight items with a singular functioning in both sexes and belonging to the subscales of proactivity, resilience and support network. These findings can be explained by gender stereotypes, since the dimensions where there are differences have an important social burden.
C1 [Caceres-Matos, Rocio; Vazquez-Santiago, Soledad; Pabon-Carrasco, Manuel; Gil-Garcia, Eugenia] Univ Seville, Fac Nursing Physiotherapy & Podiatry, Nursing Dept, Res Grp CTS 1050 Complex Care Chron & Hlth Outcome, Seville 41009, Spain.
   [Cabrera-Leon, Andres] Andalusian Sch Publ Hlth, Dept Publ Hlth, Granada 18011, Spain.
   [Cabrera-Leon, Andres] Biomed Res Consortium Epidemiol & Publ Hlth Networ, Madrid 28029, Spain.
C3 University of Sevilla; Escuela Andaluza de Salud Publica
RP Vázquez-Santiago, S; Pabón-Carrasco, M (corresponding author), Univ Seville, Fac Nursing Physiotherapy & Podiatry, Nursing Dept, Res Grp CTS 1050 Complex Care Chron & Hlth Outcome, Seville 41009, Spain.
EM rcaceres3@us.es; svazquez@us.es; mpabon@cruzroja.es;
   andres.cabrera.easp@juntadeandalucia.es; egil@us.es
RI Vázquez-Santiago, Soledad/AAO-2694-2020; Pabón Carrasco,
   Manuel/ABI-5731-2020; Gil-García, Eugenia/K-5181-2017; Cabrera León,
   Andrés/D-2723-2011; Cáceres-Matos, Rocío/GSE-3083-2022
OI Vázquez-Santiago, Soledad/0000-0003-0607-330X; Pabón Carrasco,
   Manuel/0000-0002-9011-3695; Gil-García, Eugenia/0000-0003-3862-6845;
   Cabrera León, Andrés/0000-0002-4812-1026; Cáceres-Matos,
   Rocío/0000-0003-3529-3686
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NR 86
TC 1
Z9 1
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2024
VL 12
IS 6
AR 695
DI 10.3390/healthcare12060695
PG 21
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA MH1G1
UT WOS:001192636000001
PM 38540659
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Dean-Clower, E
   Doherty-Gilman, AM
   Keshaviah, A
   Baker, F
   Kaw, C
   Lu, WD
   Manola, J
   Penson, RT
   Matulonis, UA
   Rosenthal, DS
AF Dean-Clower, Elizabeth
   Doherty-Gilman, Anne M.
   Keshaviah, Aparna
   Baker, Frank
   Kaw, Chiewkwei
   Lu, Weidong
   Manola, Judith
   Penson, Richard T.
   Matulonis, Ursula A.
   Rosenthal, David S.
TI Acupuncture as Palliative Therapy for Physical Symptoms and Quality of
   Life for Advanced Cancer Patients
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; palliative care; symptom management; ovarian cancer; breast
   cancer
ID ALTERNATIVE MEDICINE USE; BREAST-CANCER; SHORT-FORM; COMPLEMENTARY;
   PAIN; ELECTROACUPUNCTURE; PREVALENCE; ATTITUDES; SURVIVORS; PROFILE
AB Background. Acupuncture is underutilized as an adjunct cancer therapy. The main study objectives were to determine the feasibility of administering acupuncture as palliative therapy to patients with advanced ovarian or breast cancer and to assess the effect on symptoms and quality of life (QOL). Methods. This study was a pilot, single-armed prospective clinical trial for patients with advanced cancer to receive 12 acupuncture sessions over 8 weeks with follow-up at weeks 9 and 12. Ambulatory patients with advanced ovarian or breast cancer were enrolled to receive treatments at an outpatient academic oncology center. Symptom severity was measured before and after each acupuncture session. A composite QOL assessment tool, consisting of validated instruments, was completed at 5 time points. Results. Forty patients enrolled in the study. Twenty-eight patients (70%; 95% confidence interval [CI] = 53%-83%) completed 4 weeks of treatment, and 26 patients (65%; 95% CI = 48%-79%) completed 8 weeks. Eight patients (20%) withdrew before receiving acupuncture, and 6 patients (15%) discontinued treatment early because of disease progression or scheduling demands. Among all 32 assessed patients, there was self-reported improvement immediately post-treatment in anxiety, fatigue, pain, and depression and significant improvement over time for patients with anxiety (P=.001) and depression (P=.02). Among patients experiencing baseline symptoms, there was improvement in anxiety (P=.001), fatigue (P=.0002), pain (P=.0002), and depression (P=.003). QOL measures of pain severity and interference, physical and psychological distress, life satisfaction, and mood states showed improved scores during treatment, with sustained benefit at 12 weeks. Conclusions. This pilot study demonstrates that an 8-week outpatient acupuncture course is feasible for advanced cancer patients and produces a measurable benefit that should be evaluated in controlled trials.
C1 [Rosenthal, David S.] Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, Boston, MA 02115 USA.
   [Baker, Frank] New York Med Coll, Ctr Med Outcomes Res, Sch Hlth Sci & Practice, Valhalla, NY 10595 USA.
   [Kaw, Chiewkwei] Amer Canc Soc, Atlanta, GA 30329 USA.
   [Keshaviah, Aparna; Penson, Richard T.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Dean-Clower, Elizabeth; Lu, Weidong; Penson, Richard T.; Matulonis, Ursula A.; Rosenthal, David S.] Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; New York Medical College; American Cancer Society;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School
RP Rosenthal, DS (corresponding author), Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, 44 Binney St, Boston, MA 02115 USA.
EM drose@uhs.harvard.edu
RI Lu, Weidong/C-3844-2008
OI Lu, Weidong/0000-0003-2838-6307; Keshaviah, Aparna/0000-0002-4324-6807
FU National Center for Complementary and Alternative Medicine (NCCAM) [5
   R21 AT01010-02]
FX This study was supported by the National Center for Complementary and
   Alternative Medicine (NCCAM) [grant # 5 R21 AT01010-02]. Its contents
   are solely the responsibility of the authors and do not necessarily
   represent the official views of the NCCAM or the National Institutes of
   Health.
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NR 45
TC 58
Z9 71
U1 1
U2 30
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2010
VL 9
IS 2
BP 158
EP 167
DI 10.1177/1534735409360666
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Integrative & Complementary Medicine
GA 617HW
UT WOS:000279272600004
PM 20483875
OA gold
DA 2026-01-16
ER

PT J
AU Dios, PD
   Lestón, JS
AF Diz Dios, Pedro
   Seoane Leston, Juan
TI Oral cancer pain
SO ORAL ONCOLOGY
LA English
DT Review
DE Oral cancer; Pain; Analgesic; Opioid; Neural blockade
ID QUALITY-OF-LIFE; EPIDURAL MORPHINE; CARCINOMA; SURGERY; RELIEF; HEAD
AB Pain may be the initial symptom in oral cancer, and is a common complaint both in patients awaiting treatment and in those already in treatment. However, little has been published in the literature on the management of oral cancer pain.
   Effective pain control requires a multimodal approach in which pharmacological management based on the World Health Organization (WHO) analgesic ladder continues to play an essential role. Although different routes are available for the administration of analgesics, oral delivery continues to be the principal route for pain control in the. first instance.
   Interventional approaches include blockade of a peripheral nerve or of the relevant ganglion, and the use of central neuraxial blockade. The intraventricular or intrathecal administration of opioids, with or without local anaesthetics, has been indicated for severe intractable pain. The development of new treatment modalities provides additional options, though further clinical research is required.
   There is no evidence of the efficacy of non-pharmacological methods such as acupuncture or transcutaneous nerve stimulation in the management of oral cancer pain. Surgery, radiation therapy, and chemotherapy have also been suggested, but their results have not been quantified. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Diz Dios, Pedro; Seoane Leston, Juan] Univ Santiago de Compostela, Sch Med & Dent, Santiago De Compostela 15782, A Coruna, Spain.
C3 Universidade de Santiago de Compostela
RP Dios, PD (corresponding author), Univ Santiago de Compostela, Sch Med & Dent, C Entrerrios Sn, Santiago De Compostela 15782, A Coruna, Spain.
EM pedro.diz@usc.es
RI Diz, Peo/A-3467-2012
OI Diz, Peo/0000-0002-1483-401X
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NR 33
TC 26
Z9 30
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1368-8375
EI 1879-0593
J9 ORAL ONCOL
JI Oral Oncol.
PD JUN
PY 2010
VL 46
IS 6
BP 448
EP 451
DI 10.1016/j.oraloncology.2010.02.017
PG 4
WC Oncology; Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Dentistry, Oral Surgery & Medicine
GA 607UY
UT WOS:000278533700016
PM 20308009
DA 2026-01-16
ER

PT J
AU Yang, W
   Zhang, YK
   Yang, GY
   Geng, YH
   Chen, D
   Wang, J
   Ye, Y
   Wang, HC
   Xia, DJ
   Hu, FL
   Jiang, J
   Xu, XF
AF Yang, Wei
   Zhang, Yeke
   Yang, Gaoyi
   Geng, Yanhua
   Chen, Da
   Wang, Jun
   Ye, Yang
   Wang, Huaichong
   Xia, Dajing
   Hu, Fuliang
   Jiang, Jing
   Xu, Xiaofeng
TI Anti-PD-1 Immunotherapy and Bee Venom for Relapsed and Refractory
   Liposarcoma: A Case Report
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE bee venom; PD-1 inhibitor; STING pathway; immunotherapy; apitherapy;
   liposarcoma; innate immunity; complementary medicine
ID MELITTIN; BLOCKADE; CELLS
AB Cancer immunotherapies, including immune checkpoint inhibitors, elicit long-term clinical responses but many cancer patients do not respond. Intensive efforts are therefore underway to identify additional immune pathways that may be modulated to enhance the efficacy of existing immunotherapies. Bee venom strongly stimulates the immune system, and is used as a complementary therapy to treat cancer pain in patients with advanced tumors in China. Bee venom contains several allergenic protease inhibitors and peptides. It triggers hypersensitivity reactions; that is, it is an immune system agonist. The generation of a spontaneous T cell response against tumor-associated antigens requires innate immune activation; this drives type I interferon production. We report a patient with a relapsed and refractory liposarcoma who had undergone several operations, chemotherapies, and radiotherapies. The tumor was large. The patient had attained the maximum radiation exposure dose. The tumor was resistant to chemotherapy and was infiltrating the pericardium, lungs, and diaphragm. The patient was a poor candidate for resection. He thus received apitherapy (a combination of bee venom and acupuncture) to control pain; then apatinib (an anti-angiogenic drug) was given to inhibit tumor growth but was terminated early because the patient could not tolerate the side effects. Subsequently, a programmed death 1 inhibitor was combined with apitherapy. Bee venom served as an innate immune system agonist promoting immune cell priming and recruitment in the tumor microenvironment. The patient was finally able to undergo radical liposarcoma resection, and no evidence of recurrence was found at re-examination 16 months after surgery.
C1 [Yang, Wei; Zhang, Yeke; Jiang, Jing; Xu, Xiaofeng] Hangzhou Red Cross Hosp, Dept Oncol, Hangzhou, Peoples R China.
   [Yang, Gaoyi] Hangzhou Red Cross Hosp, Dept Med Imaging, Hangzhou, Peoples R China.
   [Geng, Yanhua] Hangzhou Red Cross Hosp, Dept Pathol, Hangzhou, Peoples R China.
   [Chen, Da] Hangzhou Red Cross Hosp, Dept Thorac Surg, Hangzhou, Peoples R China.
   [Wang, Jun; Ye, Yang] Hangzhou Red Cross Hosp, Dept Tradit Chinese Med, Hangzhou, Peoples R China.
   [Wang, Huaichong] Hangzhou Red Cross Hosp, Dept Pharm, Hangzhou, Peoples R China.
   [Xia, Dajing] Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Toxicol, Hangzhou, Peoples R China.
   [Hu, Fuliang] Zhejiang Univ, Coll Anim Sci, Hangzhou, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Xu, XF (corresponding author), Hangzhou Red Cross Hosp, Dept Oncol, Hangzhou, Peoples R China.
EM zjszxyjhyy1941@126.com
FU Hangzhou Municipal Health and Family Planning Commission [0020190125,
   0020190293, ZD20200004]
FX The Medical and Health Research Project Funded by the Hangzhou Municipal
   Health and Family Planning Commission (Project Number: 0020190125,
   0020190293 and ZD20200004).
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NR 57
TC 5
Z9 6
U1 2
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD APR 29
PY 2021
VL 11
AR 668992
DI 10.3389/fonc.2021.668992
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SB1YU
UT WOS:000649798200001
PM 33996596
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, Q
   Xu, HQ
   Chen, H
   Chen, XY
   Ji, WT
   Cai, MJ
   Fu, H
   Li, H
   Hou, CM
   Gao, J
AF Yang, Qing
   Xu, Huiqiong
   Chen, Huan
   Chen, Xinyu
   Ji, Wenting
   Cai, Minjin
   Fu, Han
   Li, Hang
   Hou, Chaoming
   Gao, Jing
TI Summary of evidence on Traditional Chinese Medicine nursing
   interventions in hospice care for patients with advanced cancer
SO GERIATRIC NURSING
LA English
DT Article
DE Advanced cancer; Hospice care; Traditional Chinese medicine nursing;
   interventions; Evidence summary; Evidence-based care
ID INTEGRATIVE PALLIATIVE CARE; HEALTH; ACUPUNCTURE; PAIN
AB Background: Patients with advanced cancer experience physical and psychological pain that affects their quality of life. This review aimed to systematically search, evaluate, and summarize the best evidence on Traditional Chinese Medicine (TCM) nursing interventions in hospice care for patients with advanced cancer and to provide an evidence-based foundation for clinical care. The time limit for the search was from 2010 to September 2024. Methods: A top-down search of relevant literature was conducted according to the "6S" evidence model, including clinical decisions, guidelines, best practices, evidence summaries, systematic reviews, expert consensus, and randomized controlled trials (RCTs). The literature was evaluated, and evidence was extracted independently by two researchers. The evidence was appraised using the Appraisal of Guidelines Research and Evaluation (AGREE) tool and integrated with an evidence-based team consisting of six members. Results: Thirty-three publications were included, including four guidelines, two expert consensus, two clinical decisions, two evidence summaries, twenty-one systematic reviews, and two RCTs. Thirty-six indicators of best evidence were summarized from eight areas: TCM therapy, acupuncture therapy, moxibustion therapy, acupressure therapy, music therapy, traditional Chinese exercise therapy, auricular therapy, and aromatherapy. Conclusion: This review summarizes the best evidence for TCM nursing interventions in hospice care for patients with advanced cancer, which can be used by clinical healthcare professionals to develop appropriate TCM nursing interventions in combination with the actual situation and with full consideration of the needs and wishes of the patients and their families to improve the patients' quality of life in advanced stages. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Yang, Qing; Xu, Huiqiong; Chen, Huan; Chen, Xinyu; Ji, Wenting; Cai, Minjin; Fu, Han; Li, Hang; Hou, Chaoming; Gao, Jing] Chengdu Univ Tradit Chinese Med, Coll Nursing, 1166 Liutai Rd, Chengdu 611137, Sichuan, Peoples R China.
   [Hou, Chaoming] Sichuan Univ, West China Hosp, Canc Ctr,Dept Med Oncol, Div Abdominal Tumor Multimodal Treatment, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Sichuan University
RP Hou, CM; Gao, J (corresponding author), Chengdu Univ Tradit Chinese Med, Coll Nursing, 1166 Liutai Rd, Chengdu 611137, Sichuan, Peoples R China.
EM 983729484@qq.com; 19942021@cdutcm.edu.cn
FU Project of Sichuan Mental Health Education Research Center
   [XLJKJY2203A]; Sichuan Provincial Administration of Traditional Chinese
   Medicine [2023MS442]
FX This research project was supported by Project of Sichuan Mental Health
   Education Research Center [No. XLJKJY2203A] , Sichuan Provincial
   Administration of Traditional Chinese Medicine [No. 2023MS442] .
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NR 68
TC 4
Z9 4
U1 14
U2 36
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD JAN-FEB
PY 2025
VL 61
BP 240
EP 249
DI 10.1016/j.gerinurse.2024.11.007
EA NOV 2024
PG 10
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA N0B6F
UT WOS:001361091500001
PM 39566235
DA 2026-01-16
ER

PT J
AU Tsao, Y
   Creedy, DK
AF Tsao, Ying
   Creedy, Debra K.
TI Auricular acupressure: reducing side effects of chemotherapy in women
   with ovarian cancer
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Auricular acupressure; Chemotherapy; Ovarian cancer; Side effect
   management; Women
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; SYMPTOM CLUSTERS; PAIN;
   ACUPUNCTURE; MANAGEMENT; ACUPOINT; FATIGUE; IMPACT
AB Purpose Many women with ovarian cancer may experience adverse effects from adjuvant chemotherapy after surgery. Non-pharmacological interventions can be used to reduce these side effects. We tested auricular acupressure to reduce treatment side effects in this population. Methods A prospective, quasi-randomized controlled trial was carried out at a publicly-funded hospital in southern Taiwan. Thirty-four women in the intervention group received auricular acupressure at four points (Shenmen, subcortex, endocrine, and heart), three times per day for 3 min per time, for 6 weeks. Thirty-one women in the control group received routine nursing care alone. The M. D. Anderson Symptom Inventory (MDASI) was completed at four time points. Results After receiving the third cycle of chemotherapy, side effect severity was elevated among both groups. Auricular acupressure reduced side effects such as disturbed sleep (t = - 11.99; p < .001, eta squared = 0.69), fatigue (t = - 2.57; p < .01, eta squared = 0.10), and lack of appetite (t = - 2.37; p = .024, eta squared = 0.08). Conclusion Auricular acupressure can reduce adverse side effects of chemotherapy in women with ovarian cancer. Future studies with a larger sample and using some laboratory-based tests (such as C-reactive protein, interleukin-6) are warranted to confirm the results.
C1 [Tsao, Ying] Tzu Chi Univ, Dept Nursing, 701,Zhongyang Rd,Sect 3, Hualien 97004, Taiwan.
   [Creedy, Debra K.] Griffith Univ, Sch Nursing & Midwifery, Brisbane, Qld, Australia.
C3 Tzu Chi University; Griffith University
RP Tsao, Y (corresponding author), Tzu Chi Univ, Dept Nursing, 701,Zhongyang Rd,Sect 3, Hualien 97004, Taiwan.
EM s2178593@mail.tcu.edu.tw; d.creedy@griffith.edu.au
RI Tsao, Ying/AAQ-4240-2020; Creedy, Debra/AAD-2600-2021
OI Tsao, Ying/0000-0002-5131-3344; Creedy, Debra/0000-0002-3046-4143
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NR 38
TC 17
Z9 19
U1 2
U2 56
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD NOV
PY 2019
VL 27
IS 11
BP 4155
EP 4163
DI 10.1007/s00520-019-04682-8
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA JF6CZ
UT WOS:000491476800015
PM 30796521
DA 2026-01-16
ER

PT J
AU Ordoñez-Mora, LT
   Rosero, ID
   Morales-Osorio, MA
   Guil, R
   Jordan, GQ
   Jimenez, JAA
   Gonzalez-Ruiz, K
   Avila-Valencia, JC
AF Ordonez-Mora, Leidy Tatiana
   Rosero, Ilem D.
   Morales-Osorio, Marco Antonio
   Guil, Rocio
   Quintero Jordan, Giancarlo
   Agudelo Jimenez, Julian Alberto
   Gonzalez-Ruiz, Katherine
   Avila-Valencia, Juan Carlos
TI NEUROCANTRIAL: study protocol for a randomised controlled trial of a
   pain neuroscience education programme in adults with cancer pain
SO BMJ OPEN
LA English
DT Article
DE Cancer pain; Pain management; REHABILITATION MEDICINE; PALLIATIVE CARE;
   Health Education
ID QUALITY-OF-LIFE; SPANISH VERSION; MUSCULOSKELETAL PAIN; VALIDATION;
   SURVIVORS; HEALTH; SCALE
AB IntroductionPain is the second most frequent symptom reported in patients with cancer among the main reasons for consultation. The incorporation of educational modalities in pain intervention processes has been suggested. This study aims to examine the efficacy of neuroscience pain education (PNE) in relation to pain, biopsychosocial variables and functional capacity in comparison with conventional treatment. It is hypothesised that an intervention based on PNE achieves better outcomes than conventional management, in terms of pain, biopsychosocial variables and functional capacity in adults with oncological pain.Methods and analysisThis will be a single-blind, controlled clinical trial in which two groups will be compared using changes in pain as the primary measure. The first group will receive conventional treatment in addition to PNE, and participants will undergo an intervention of nine sessions (one session per week, for a total of 9 weeks), each lasting 30-40 min. Specifically, these sessions will teach biophysiological elements using metaphors that allow the adoption of these concepts related to pain. The second group will receive conventional treatment (pharmacological treatment). For this study, a sample size calculation was made based on the background, where 80 adults with oncological pain were required. An initial evaluation will be made to establish the baseline characteristics, and then, according to the randomisation, the assignment to the PNE group or the control group will be made and the two groups will be summoned again. Ten weeks later, for the intervention evaluation, the statistical analysis plan will be established by protocol and by intention-to-treat.Ethics and disseminationThis protocol complies with all ethical considerations. The authors commit to presenting the study's results. This study was approved by the ethics committees of the Universidad Santiago de Cali, Clinica de Occidente/Angiografia de Occidente. The authors commit to presenting the study's results.Trial registration numberNCT05581784.
C1 [Ordonez-Mora, Leidy Tatiana] Univ Santiago Cali, Doctorate Appl Sci, Cali, Colombia.
   [Ordonez-Mora, Leidy Tatiana] Univ Cadiz, Doctorate Hlth Sci, Cadiz, Spain.
   [Rosero, Ilem D.; Gonzalez-Ruiz, Katherine; Avila-Valencia, Juan Carlos] Univ Santiago Cali, Dept Hlth, Physiotherapy Program, Cali, Colombia.
   [Morales-Osorio, Marco Antonio] Univ Costa, Dept Hlth, Barranquilla, Colombia.
   [Morales-Osorio, Marco Antonio] Univ Valle Puebla, Dept Hlth, Puebla, Mexico.
   [Guil, Rocio] Univ Cadiz, Dept Psychol, Puerto Real, Spain.
   [Quintero Jordan, Giancarlo] Univ Santiago Cali, Hlth & Movement Res Grp, Cali, Colombia.
   [Agudelo Jimenez, Julian Alberto; Avila-Valencia, Juan Carlos] Ctr Med Clin Occidente, Grp Invest & Educ Clin Occidente GIECDO, Cali, Valle Del Cauca, Colombia.
C3 Universidad Santiago de Cali; Universidad de Cadiz; Universidad Santiago
   de Cali; Universidad de la Costa; Universidad de Cadiz; Universidad
   Santiago de Cali
RP Ordoñez-Mora, LT (corresponding author), Univ Santiago Cali, Doctorate Appl Sci, Cali, Colombia.
EM tatiana.ormora@gmail.com
RI Ordoñez-Mora, Leidy Tatiana/AAL-6397-2021; González-Ruíz,
   Katherine/CAA-4624-2022; Rosero, Ilem/AHB-1606-2022; Guil,
   Rocio/A-7946-2013
OI Ordoñez-Mora, Leidy Tatiana/0000-0001-8365-8155; Avila Valencia, Juan
   Carlos/0000-0003-3642-6428; González-Ruíz,
   Katherine/0000-0001-7518-0761; Rosero, Ilem/0000-0001-6843-7047; Guil,
   Rocio/0000-0003-4425-2800
FU General Directorate of Research initiation act of the Universidad
   Santiago de Cali [442- 621121- 3331]; Direccion General de
   Investigaciones of Universidad Santiago de Cali [02-2023]
FX This project is funded by the General Directorate of Research initiation
   act (number: 442- 621121- 3331) of the Universidad Santiago de Cali.
   This research has been funded by Direccion General de Investigaciones of
   Universidad Santiago de Cali under call number 02-2023.
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NR 48
TC 1
Z9 1
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD SEP
PY 2023
VL 13
IS 9
AR e071493
DI 10.1136/bmjopen-2022-071493
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T4BO7
UT WOS:001077459700027
PM 37758676
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Xu, ZH
   Wang, XB
   Wu, YY
   Wang, CB
   Fang, XD
AF Xu, Zhonghang
   Wang, Xingbo
   Wu, Yuanyu
   Wang, Chengbing
   Fang, Xuedong
TI The effectiveness and safety of acupuncture for chemotherapy-induced
   peripheral neuropathy: A systematic review and meta-analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE chemotherapy-induced peripheral neuropathy; acupuncture; systematic
   review; meta-analysis; physiotherapy
ID QUALITY-OF-LIFE; GRADING QUALITY; CANCER; PAIN; ELECTROACUPUNCTURE;
   BREAST; RECOMMENDATIONS; STRENGTH; QLQ-C30
AB Objectives: This systematic review and meta-analysis aimed to evaluate the effectiveness and safety of acupuncture on chemotherapy-induced peripheral neuropathy (CIPN).
   Methods: We searched for relevant randomized controlled trials (RCTs) in PubMed, Cochrane Library, and Embase databases from their inception to 1 April 2022. The Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), Brief Pain Inventory-Short Form (BPI-SF), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (EORTC QLQ-C30), Numerical Rating Scale (NRS), and adverse events were the outcome measures. All studies had at least one of these outcome measures. Mean differences (MDs) with 95% confidence intervals (CIs) were assessed in the meta-analysis using the RevMan 5.3 software.
   Results: Five studies were included in the analysis. The results showed that acupuncture and placebo acupuncture were not significantly different in reducing chemotherapy-induced neurotoxicity and functional disability (random-effects estimates; MD: 4.30; 95% CI: -0.85 similar to 9.45; P = 0.10; I-2 = 74%). Acupuncture was better than placebo acupuncture in reducing pain severity and pain interference with patients' daily function (fixed-effect estimates; MD: -1.14; 95% CI: 1.87 to -0.42; P = 0.002; I-2 = 13%). Acupuncture was not significantly different from placebo acupuncture in relieving CIPN symptoms (MD: -0.81; 95% CI: -2.02 to 0.40, P = 0.19). Acupuncture improved quality of life better than placebo acupuncture (MD: 10.10; 95% CI: 12.34 to 17.86, P = 0.01). No severe adverse events were recorded in all five studies.
   Conclusion: This meta-analysis suggests that acupuncture may be more effective and safer in reducing pain severity and pain interference with patients' daily function than placebo acupuncture. Additionally, acupuncture may improve the quality of life of patients with CIPN. However, large sample size studies are needed to confirm this conclusion.
C1 [Xu, Zhonghang; Wang, Xingbo; Wu, Yuanyu; Wang, Chengbing; Fang, Xuedong] Jilin Univ, China Japan Union Hosp, Changchun, Peoples R China.
C3 Jilin University
RP Fang, XD (corresponding author), Jilin Univ, China Japan Union Hosp, Changchun, Peoples R China.
EM fangxd@jlu.edu.cn
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NR 40
TC 17
Z9 21
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 3
PY 2022
VL 13
AR 963358
DI 10.3389/fneur.2022.963358
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5N9NW
UT WOS:000872113700001
PM 36262831
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kasymjanova, G
   Grossman, M
   Tran, T
   Jagoe, RT
   Cohen, V
   Pepe, C
   Small, D
   Agulnik, J
AF Kasymjanova, G.
   Grossman, M.
   Tran, T.
   Jagoe, R. T.
   Cohen, V.
   Pepe, C.
   Small, D.
   Agulnik, J.
TI The potential role for acupuncture in treating symptoms in patients with
   lung cancer: an observational longitudinal study
SO CURRENT ONCOLOGY
LA English
DT Article
DE Acupuncture; lung cancer; Edmonton Symptom Assessment System; ESAS;
   pain; integrative oncology clinics; narcotics
ID QUALITY-OF-LIFE; VISUAL ANALOG SCALE; PAIN; CHEMOTHERAPY; PREVALENCE;
   DEPRESSION; MANAGEMENT; DISTRESS; MEDICINE; FATIGUE
AB Background
   Most lung cancer patients experience multiple symptoms related either to the disease or its treatment. The commonly reported symptoms are pain, depression, anxiety, nausea, and poor well-being. The aim of the present study was to evaluate the effect of acupuncture as a potential treatment modality in symptomatic lung cancer patients.
   Methods
   This prospective observational study enrolled 33 lung cancer patients from the Peter Brojde Lung Cancer Centre between August 2010 and May 2012. All patients received 45-minute sessions of acupuncture, 1-2 times weekly for a minimum of 4 sessions. Symptom severity was assessed using the Edmonton Symptom Assessment System (esas) before and after completion of acupuncture.
   Results
   The study cohort included 30 patients with non-small- cell lung cancer and 3 with small-cell lung cancer. Mean age was 62 years (range: 36-88 years); 17 of the patients were women. Most of the patients had advanced-stage cancer (73%) and good performance status (Eastern Cooperative Oncology Group 0-1: 88%). Of these patients, 67% received anticancer treatment (chemotherapy or radiotherapy, or both) with acupuncture. Of the remaining 10 patients, 8 received acupuncture after a complete surgical resection of their tumour, and because of their advanced age, 2 received acupuncture and best supportive care. The median number of acupuncture sessions was 7 (interquartile range: 4-13 sessions). Statistically significant improvements in pain, appetite, nausea, nervousness, and well-being were observed. A clinically important improvement (2 points on the esas) was reported by 61% of patients for pain and by 33% for well-being.
   A significant positive correlation between improved well-being and the number of acupuncture sessions was observed. This correlation remained significant even after controlling for treatment and narcotic use. Receiver operating characteristic analysis demonstrated that a minimum of 6 acupuncture sessions are required for a 70% chance of a clinically important improvement in well-being.
   Conclusions
   The present study is the first to demonstrate that acupuncture may be an effective approach for improving symptoms-in particular, pain and well-being-in lung cancer patients. Acupuncture is a safe and minimally invasive procedure, and it is potentially useful even in patients undergoing anticancer treatment.
C1 [Kasymjanova, G.; Grossman, M.; Tran, T.; Cohen, V.; Pepe, C.; Small, D.; Agulnik, J.] Peter Brojde Lung Canc Ctr, Montreal, PQ, Canada.
   [Kasymjanova, G.; Grossman, M.; Jagoe, R. T.; Cohen, V.; Pepe, C.; Small, D.; Agulnik, J.] McGill Univ, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada.
   [Jagoe, R. T.] McGill Canc Nutr Rehabil Clin, Montreal, PQ, Canada.
C3 Jewish General Hospital - Montreal; McGill University
RP Kasymjanova, G (corresponding author), McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Peter Brojde Lung Canc Ctr, 3755 Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada.
EM gkasymja@jgh.mcgill.ca
RI Jagoe, R Thomas/AFV-6633-2022
OI Jagoe, R Thomas/0000-0001-7069-0519
CR *AC PROD, 2007, ATL AC POINTS POINT
   Ahn AC, 2005, ALTERN THER HEALTH M, V11, P40
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NR 39
TC 16
Z9 30
U1 1
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1198-0052
EI 1718-7729
J9 CURR ONCOL
JI Curr. Oncol.
PD JUN
PY 2013
VL 20
IS 3
BP 152
EP 157
DI 10.3747/co.20.1312
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 158KR
UT WOS:000319969800020
PM 23737683
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Epstein, AS
   Liou, KT
   Romero, SAD
   Baser, RE
   Wong, G
   Xiao, H
   Mo, ZL
   Walker, D
   MacLeod, J
   Li, Q
   Barton-Burke, M
   Deng, GE
   Panageas, KS
   Farrar, JT
   Mao, JJ
AF Epstein, Andrew S.
   Liou, Kevin T.
   Romero, Sally A. D.
   Baser, Raymond E.
   Wong, Greta
   Xiao, Han
   Mo, Zunli
   Walker, Desiree
   MacLeod, Jodi
   Li, Qing
   Barton-Burke, Margaret
   Deng, Gary E.
   Panageas, Katherine S.
   Farrar, John T.
   Mao, Jun J.
TI Acupuncture vs Massage for Pain in Patients Living With Advanced Cancer:
   The IMPACT Randomized Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID BREAST-CANCER; SYMPTOMS; OPIOIDS; METAANALYSIS; SEVERITY; OUTCOMES;
   FATIGUE
AB Importance Pain is challenging for patients with advanced cancer. While recent guidelines recommend acupuncture and massage for cancer pain, their comparative effectiveness is unknown.Objective To compare the effects of acupuncture and massage on musculoskeletal pain among patients with advanced cancer.Design, Setting, and Participants A multicenter pragmatic randomized clinical trial was conducted at US cancer care centers consisting of a northeastern comprehensive cancer center and a southeastern cancer institute from September 19, 2019, through February 23, 2022. The principal investigator and study statisticians were blinded to treatment assignments. The duration of follow-up was 26 weeks. Intention-to-treat analyses were performed (linear mixed models). Participants included patients with advanced cancer with moderate to severe pain and clinician-estimated life expectancy of 6 months or more. Patient recruitment strategy was multipronged (eg, patient database queries, mailings, referrals, community outreach). Eligible patients had English or Spanish as their first language, were older than 18 years, and had a Karnofsky score greater than or equal to 60 (range, 0-100; higher scores indicating less functional impairment).Interventions Weekly acupuncture or massage for 10 weeks with monthly booster sessions up to 26 weeks.Main Outcomes and Measures The primary end point was the change in worst pain intensity score from baseline to 26 weeks. The secondary outcomes included fatigue, insomnia, and quality of life. The Brief Pain Inventory (range, 0-10; higher numbers indicate worse pain intensity or interference) was used to measure the primary outcome. The secondary outcomes included fatigue, insomnia, and quality of life.Results A total of 298 participants were enrolled (mean [SD] age, 58.7 [14.1] years, 200 [67.1%] were women, 33 [11.1%] Black, 220 [74.1%] White, 46 [15.4%] Hispanic, and 78.5% with solid tumors). The mean (SD) baseline worst pain score was 6.9 (1.5). During 26 weeks, acupuncture reduced the worst pain score, with a mean change of -2.53 (95% CI, -2.92 to -2.15) points, and massage reduced the Brief Pain Inventory worst pain score, with a mean change of -3.01 (95% CI, -3.38 to -2.63) points; the between-group difference was not significant (-0.48; 95% CI, -0.98 to 0.03; P = .07). Both treatments also improved fatigue, insomnia, and quality of life without significant between-group differences. Adverse events were mild and included bruising (6.5% of patients receiving acupuncture) and transient soreness (15.1% patients receiving massage).Conclusions and Relevance In this randomized clinical trial among patients with advanced cancer, both acupuncture and massage were associated with pain reduction and improved fatigue, insomnia, and quality of life over 26 weeks; however, there was no significant different between the treatments. More research is needed to evaluate how best to integrate these approaches into pain treatment to optimize symptom management for the growing population of people living with advanced cancer.Trial RegistrationClinicalTrials.gov Identifier: NCT04095234
C1 [Epstein, Andrew S.] Mem Sloan Kettering Canc Ctr, 300 66th St,Room 1013, New York, NY 10065 USA.
   [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, 321 61st St,Room 1013, New York, NY 10065 USA.
   [Epstein, Andrew S.; Liou, Kevin T.; Wong, Greta; Xiao, Han; Walker, Desiree; MacLeod, Jodi; Li, Qing; Deng, Gary E.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
   [Romero, Sally A. D.] Univ Calif San Diego, Dept Obstet Gynecol & Reprod Sci, San Diego, CA USA.
   [Baser, Raymond E.; Panageas, Katherine S.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA.
   [Mo, Zunli] Baptist Hlth Miami Canc Inst, Canc Patient Support Ctr, Miami, FL USA.
   [Barton-Burke, Margaret] Mem Sloan Kettering Canc Ctr, Off Nursing Res, New York, NY USA.
   [Farrar, John T.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; University of California
   System; University of California San Diego; Memorial Sloan Kettering
   Cancer Center; Memorial Sloan Kettering Cancer Center; University of
   Pennsylvania
RP Epstein, AS (corresponding author), Mem Sloan Kettering Canc Ctr, 300 66th St,Room 1013, New York, NY 10065 USA.; Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, 321 61st St,Room 1013, New York, NY 10065 USA.
EM epsteina@mskcc.org; maoj@mskcc.org
RI Farrar, John/AAP-4788-2021
FU PCORI award [SMPAI-2018C2-12883]; NIH/National Cancer Institute (NCI)
   Cancer Center [P30 CA008748]; NCI [R01 CA240417]; National Cancer
   Institute [P30CA008748, K08CA266927] Funding Source: NIH RePORTER
FX Research reported in this article was funded through a PCORI award
   (SMPAI-2018C2-12883 to Dr Mao through Memorial Sloan Kettering Cancer
   Center). This work was also supported in part by an NIH/National Cancer
   Institute (NCI) Cancer Center grant to Memorial Sloan Kettering Cancer
   Center (P30 CA008748). Dr Mao was supported in part by NCI grant R01
   CA240417.
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NR 44
TC 37
Z9 45
U1 5
U2 32
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD NOV 14
PY 2023
VL 6
IS 11
AR e2342482
DI 10.1001/jamanetworkopen.2023.42482
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Y7MY8
UT WOS:001107078100009
PM 37962891
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Garcia, MK
   Cohen, L
   Guo, Y
   Zhou, YH
   You, B
   Chiang, J
   Orlowski, RZ
   Weber, D
   Shah, J
   Alexanian, R
   Thomas, S
   Romaguera, J
   Zhang, L
   Badillo, M
   Chen, YM
   Wei, Q
   Lee, R
   Delasalle, K
   Green, V
   Wang, M
AF Garcia, M. Kay
   Cohen, Lorenzo
   Guo, Ying
   Zhou, Yuhong
   You, Bing
   Chiang, Joseph
   Orlowski, Robert Z.
   Weber, Donna
   Shah, Jatin
   Alexanian, Raymond
   Thomas, Sheeba
   Romaguera, Jorge
   Zhang, Liang
   Badillo, Maria
   Chen, Yiming
   Wei, Qi
   Lee, Richard
   Delasalle, Kay
   Green, Vivian
   Wang, Michael
TI Electroacupuncture for thalidomide/bortezomib-induced peripheral
   neuropathy in multiple myeloma: a feasibility study
SO JOURNAL OF HEMATOLOGY & ONCOLOGY
LA English
DT Article
DE Acupuncture; Myeloma; Chemotherapy; Peripheral neuropathy; Integrative
   medicine
ID RANDOMIZED CONTROLLED-TRIAL; ACUPUNCTURE TREATMENT; BORTEZOMIB; PLACEBO;
   DEXAMETHASONE; MANAGEMENT; THERAPY; PAIN; CIPN
AB Background: This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.
   Methods: Patients with neuropathy >= grade 2 received 20 acupuncture treatments over 9 weeks.
   Results: For the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002). Moderate effect size differences began on week 4, with the largest effect size differences found at week 9 for FACT/GOG/NTX scores, worst pain in the last 24 hours, and pain severity (Cohen's d = 1.43, 1.19, and 1.08, respectively) and continuing through week 13 (Cohen's d = 0.86, 0.88, and 0.90, respectively). From baseline to week 13, additional significant improvements were seen as follows: postural stability (1.0 [0.6] vs 0.8 [0.4], p = 0.02); coin test (10.0 [7.4] vs 5.6 [1.9], p < 0.0001); button test (96.1 [144.4] vs 54.9 [47.3], p < 0.0001); and walking test (21.6 [10.0] vs 17.2 [7.7], p = 0.0003). No significant changes were seen with NCS.
   Conclusions: Acupuncture may help patients experiencing thalidomide- or bortezomib-induced PN. Larger, randomized, clinical trials are needed.
   Trial registration: ClinicalTrials.gov Identifier: NCT00891618.
C1 [Garcia, M. Kay; Cohen, Lorenzo; Wei, Qi; Lee, Richard] Univ Texas MD Anderson Canc Ctr, Integrat Med Program, Houston, TX 77030 USA.
   [Guo, Ying] Univ Texas MD Anderson Canc Ctr, Dept Rehabil Med, Houston, TX 77030 USA.
   [Zhou, Yuhong] Fudan Univ, Zhongshan Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China.
   [You, Bing] Amer Coll Acupuncture & Oriental Med, Houston, TX 77063 USA.
   [Chiang, Joseph] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Perioperat Med, Houston, TX 77030 USA.
   [Orlowski, Robert Z.; Weber, Donna; Shah, Jatin; Alexanian, Raymond; Thomas, Sheeba; Romaguera, Jorge; Zhang, Liang; Badillo, Maria; Chen, Yiming; Delasalle, Kay; Green, Vivian; Wang, Michael] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA.
   [Orlowski, Robert Z.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; Fudan University; University
   of Texas System; UTMD Anderson Cancer Center; University of Texas
   System; UTMD Anderson Cancer Center; University of Texas System; UTMD
   Anderson Cancer Center
RP Wang, M (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, 1515 Holcombe Blvd,Unit 0429, Houston, TX 77030 USA.
EM miwang@mdanderson.org
RI Zhang, Li/L-5206-2013; Wei, Qi/JJF-3393-2023; Orlowski,
   Robert/ABX-6428-2022; Lee, Richard/AAS-1416-2021
OI Orlowski, Robert/0000-0002-5723-4129; Guo, Ying/0000-0002-3715-4287;
   Lee, Richard/0000-0001-9916-6155
FU Millennium Pharmaceuticals, Inc; Marvin Kimmel Research Funds at MD
   Anderson Cancer Center; National Cancer Institute [P50 CA142509, U10
   CA032102]; National Cancer Institute [P30CA016672] Funding Source: NIH
   RePORTER
FX Funding for this study was provided in part by Millennium
   Pharmaceuticals, Inc. and Marvin Kimmel Research Funds at MD Anderson
   Cancer Center. We would also like to thank Dawn Chalaire and the
   Department of Scientific Publications, The University of Texas MD
   Anderson Cancer Center for helpful editorial comments on this article.
   RO would like to acknowledge support from the National Cancer Institute
   (P50 CA142509 and U10 CA032102).
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NR 40
TC 49
Z9 56
U1 3
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-8722
J9 J HEMATOL ONCOL
JI J. Hematol. Oncol.
PD MAY 9
PY 2014
VL 7
AR 41
DI 10.1186/1756-8722-7-41
PG 8
WC Oncology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology
GA AK7DF
UT WOS:000338585700001
PM 24886772
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Genovese, TJ
   Mao, JJ
AF Genovese, Timothy J.
   Mao, Jun J.
TI Genetic Predictors of Response to Acupuncture for Aromatase
   InhibitorAssociated Arthralgia Among Breast Cancer Survivors
SO PAIN MEDICINE
LA English
DT Article
DE Acupuncture; Alternative Medicine; Joint; Musculoskeletal; Pain
   Management; Treatment Outcome
ID INHIBITOR-INDUCED ARTHRALGIA; O-METHYLTRANSFERASE COMT;
   CLINICAL-EFFICACY; PAIN; MORPHINE; WOMEN
AB Objective. To evaluate the associations between polymorphisms in two genes, catechol-O-methyltransferase and T-cell leukemia/lymphoma 1A, and acupuncture-mediated pain reduction among breast cancer survivors with aromatase inhibitorassociated arthralgia.
   Biospecimens were obtained from 38 patients enrolled in a clinical trial of acupuncture for aromatase inhibitorassociated arthralgia in postmenopausal hormone receptorpositive breast cancer survivors.
   We used polymerase chain reaction to genotype the rs4680 (Val158Met) and rs4633 (His62His) variants in the catechol-O-methyltransferase gene and rs2369049 (A > G) and rs7158782 (A > G) variants in the T-cell leukemia/lymphoma 1A gene. Response to acupuncture was defined by 30% reduction in end-of-treatment average pain, measured by the Brief Pain Inventory. We used Fisher exact tests to evaluate associations between genotype and treatment response.
   Among participants, all six (15.8%) subjects who expressed AA in locus rs4680 responded to acupuncture. In a combined analysis, the 18 (47.4%) subjects with the responder genotype at either rs4680 (AA) or rs2369049 (GG or AG) were significantly more likely to respond to acupuncture than those without (77.8% vs 45.0%, P=0.039).
   Specific genetic variations at loci rs4680 and rs2369049 are associated with response to acupuncture-type intervention for management of arthralgia. These results serve as a proof of concept for applying a precision medicine framework to the study of cancer pain management.
C1 [Genovese, Timothy J.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Dept Integrat Med, 1275 York Ave, New York, NY 10021 USA.
C3 Brown University; Memorial Sloan Kettering Cancer Center
RP Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Integrat Med Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
OI Genovese, Timothy/0000-0001-9531-8297
FU National Institutes of Health/National Center for Complementary and
   Alternative Medicine [R21 AT004695]; National Cancer Institute
   [P30-CA008748]; National Cancer Institute of the National Institutes of
   Health [R25CA020449]; MSK Translational and Integrative Medicine
   Research Fund; National Cancer Institute [P30CA008748, R25CA020449]
   Funding Source: NIH RePORTER
FX This study was supported by grants from the National Institutes of
   Health/National Center for Complementary and Alternative Medicine R21
   AT004695, a National Cancer Institute grant to the Memorial Sloan
   Kettering Cancer Center (grant number P30-CA008748), a National Cancer
   Institute of the National Institutes of Health grant (award number
   R25CA020449), and by the MSK Translational and Integrative Medicine
   Research Fund.
CR Anderson JG, 2012, J ALTERN COMPLEM MED, V18, P235, DOI 10.1089/acm.2011.0022
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NR 23
TC 9
Z9 12
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JAN
PY 2019
VL 20
IS 1
BP 191
EP 194
DI 10.1093/pm/pny067
PG 4
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA HQ1QS
UT WOS:000462173900023
PM 29912452
OA Bronze
DA 2026-01-16
ER

PT J
AU Ng, DQ
   Lee, S
   Lee, RT
   Wang, Y
   Chan, A
AF Ng, Ding Quan
   Lee, Sanghoon
   Lee, Richard T.
   Wang, Yun
   Chan, Alexandre
TI Real-world impact of acupuncture on analgesics and healthcare resource
   utilization in breast cancer survivors with pain
SO BMC MEDICINE
LA English
DT Article
DE Acupuncture; Cancer pain; Real-world evidence; Claims data; Propensity
   score; Difference-in-difference
ID QUALITY-OF-LIFE; INTEGRATIVE MEDICINE; SYMPTOM BURDEN; MANAGEMENT;
   SERVICES; SOCIETY
AB Background This study evaluated the real-world impact of acupuncture on analgesics and healthcare resource utilization among breast cancer survivors. Methods From a United States (US) commercial claims database (25% random sample of IQVIA PharMetrics (R) Plus for Academics), we selected 18-63 years old malignant breast cancer survivors experiencing pain and >= 1 year removed from cancer diagnosis. Using the difference-in-difference technique, annualized changes in analgesics [prevalence, rates of short-term (< 30-day supply) and long-term (>= 30-day supply) prescription fills] and healthcare resource utilization (healthcare costs, hospitalizations, and emergency department visits) were compared between acupuncture-treated and non-treated patients. Results Among 495 (3%) acupuncture-treated patients (median age: 55 years, stage 4: 12%, average 2.5 years post cancer diagnosis), most had commercial health insurance (92%) and experiencing musculoskeletal pain (98%). Twenty-seven percent were receiving antidepressants and 3% completed >= 2 long-term prescription fills of opioids. Prevalence of opioid usage reduced from 29 to 19% (P < 0.001) and NSAID usage reduced from 21 to 14% (P = 0.001) post-acupuncture. The relative prevalence of opioid and NSAID use decreased by 20% (P < 0.05) and 19% (P = 0.07), respectively, in the acupuncture-treated group compared to non-treated patients (n = 16,129). However, the reductions were not statistically significant after adjustment for confounding. Patients receiving acupuncture for pain (n = 264, 53%) were found with a relative decrease by 47% and 49% (both P < 0.05) in short-term opioid and NSAID fills compared to those treated for other conditions. High-utilization patients (>= 10 acupuncture sessions, n = 178, 36%) were observed with a significant reduction in total healthcare costs (P < 0.001) unlike low-utilization patients. Conclusions Although adjusted results did not show that patients receiving acupuncture had better outcomes than non-treated patients, exploratory analyses revealed that patients treated specifically for pain used fewer analgesics and those with high acupuncture utilization incurred lower healthcare costs. Further studies are required to examine acupuncture effectiveness in real-world settings.
C1 [Ng, Ding Quan; Chan, Alexandre] Univ Calif Irvine, Sch Pharm & Pharmaceut Sci, 802 Peltason Dr, Irvine, CA 92697 USA.
   [Ng, Ding Quan; Wang, Yun] Chapman Univ, Sch Pharm, RK 94-206,9401 Jeronimo Rd, Irvine, CA 92618 USA.
   [Lee, Sanghoon] Kyung Hee Univ, Coll Korean Med, Seoul, South Korea.
   [Lee, Richard T.] City Of Hope, Dept Support Care Med & Med Oncol, Integrat Med Program, Comprehens Canc Ctr, Duarte, CA USA.
C3 University of California System; University of California Irvine;
   Chapman University System; Chapman University; Kyung Hee University;
   City of Hope
RP Chan, A (corresponding author), Univ Calif Irvine, Sch Pharm & Pharmaceut Sci, 802 Peltason Dr, Irvine, CA 92697 USA.; Wang, Y (corresponding author), Chapman Univ, Sch Pharm, RK 94-206,9401 Jeronimo Rd, Irvine, CA 92618 USA.
EM yunwang@chapman.edu; a.chan@uci.edu
RI WANG, YUN/AEQ-2146-2022; Chan, Alexane/D-5035-2016; Ng, Ding
   Quan/AAS-6491-2021
OI WANG, YUN/0000-0001-9438-5586; Chan, Alexane/0000-0003-4391-4219; Ng,
   Ding Quan/0000-0002-0754-7901
FU Chapman University School of Pharmacy; Chao Family Comprehensive Cancer
   Center Biostatistics Shared Resource; National Cancer Institute of the
   National Institutes of Health [P30CA062203]
FX We acknowledge Chapman University School of Pharmacy for acquiring the
   data and IQVIA for reviewing this work. We acknowledge that any
   opinions, findings, conclusions, or recommendations expressed in this
   publication are those of the author(s) and do not necessarily reflect
   the views of IQVIA. We thank Drs Farhad Islami, Chia Jie Tan, and Daniel
   Wiese for their expert advice during the planning and analysis phases of
   the study. The authors also wish to acknowledge the support of the Chao
   Family Comprehensive Cancer Center Biostatistics Shared Resource,
   supported by the National Cancer Institute of the National Institutes of
   Health under award number P30CA062203. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 56
TC 2
Z9 2
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 16
PY 2024
VL 22
IS 1
AR 394
DI 10.1186/s12916-024-03626-2
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G2B4Z
UT WOS:001314743000003
PM 39285302
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Choi, TY
   Ang, L
   Jun, JH
   Alraek, T
   Lee, MS
AF Choi, Tae-Young
   Ang, Lin
   Jun, Ji Hee
   Alraek, Terje
   Lee, Myeong Soo
TI Acupuncture and Moxibustion for Cancer-Related Fatigue: An Overview of
   Systematic Reviews and Meta-Analysis
SO CANCERS
LA English
DT Review
DE complementary medicine; acupuncture; cancer; fatigue; systematic review
ID BREAST-CANCER; SAFETY; THERAPY; QUALITY
AB Simple Summary Acupuncture, per se, is not used for treating cancer. However, acupuncture is used for treating several cancer-related symptoms, such as, for example, pain, antiestrogen-induced hot flashes, as well as cancer-related fatigue (CRF). There are several studies that assess the evidence of acupuncture for palliative cancer treatment; but there are none for CRF. The aim of this overview, therefore, was to comprehensively summarize and critically evaluate the current evidence of the efficacy of AT in the management of CRF. Although acupuncture (AT) is used in the treatment of CRF, the evidence from different systematic reviews (SRs) of AT has not yet been comprehensively evaluated. Moxibustion, which is a treatment method that is well established within Traditional East Asian Medicine, applies the heat of burning herbs towards or onto special points on the skin. Commonly, the herb Artemisia vulgaris, is used. It has been used for palliative cancer care, as well as for CRF. The aim of this overview was to evaluate the efficacy of AT and moxibustion in the management of CRF. Eleven databases were searched through for studies that were published from their dates of inception to February 2022. The study selection, the data extraction, and the assessment were performed independently by two researchers. The methodological and report quality were assessed by using the Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool. The evidence quality was evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Fifteen SRs on AT (n = 10) and moxibustion (n = 5) treatments for CRF were included, and they include 169 randomized controlled trials and 14,392 participants. All of the SRs that were evaluated by the AMASTAR-2 had more than one deficiency, and so all of the SRs were rated as either low or critically low. For the GRADE, 18 outcomes were rated as very-low-quality evidence, 13 as low-quality evidence, 3 as moderate-quality evidence, and 0 as high-quality evidence. Most of the SRs reached the potential benefits of AT for CRF. No serious adverse effects were identified. In conclusion, the evidence suggests that, despite the advantages of AT in terms of the improvement in and the safety of the treatment of CRF, the methodological quality of most of these studies is low, which limits our ability to draw definitive meanings. Further research of high quality is needed in order to confirm these findings.
C1 [Choi, Tae-Young; Ang, Lin; Jun, Ji Hee; Lee, Myeong Soo] Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
   [Alraek, Terje] Kristiania Univ Coll, Sch Hlth Sci, N-0107 Oslo, Norway.
   [Alraek, Terje] Arctic Univ Norway, Dept Community Med, Natl Res Ctr Complementary & Alternat Med NAFKAM, Fac Hlth Sci,UiT, N-9037 Tromso, Norway.
C3 Korea Institute of Oriental Medicine (KIOM); Kristiania University
   College; UiT The Arctic University of Tromso
RP Lee, MS (corresponding author), Korea Inst Oriental Med, KM Sci Res Div, Daejeon 34054, South Korea.
EM superoung@kiom.re.kr; anglin2808@gmail.com; zhixi04@kiom.re.kr;
   terje.alrak@uit.no; drmslee@gmail.com
RI Ang, Lin/AAE-7428-2021; Alræk, Terje/AAG-7001-2021; Choi,
   TaeYoung/PAU-6282-2025; Lee, Myeong Soo/C-8147-2013
OI Ang, Lin/0000-0002-7273-9600; JUN, JI HEE/0000-0001-9084-903X; Lee,
   Myeong Soo/0000-0001-6651-7641
FU Korea Institute of Oriental Medicine, Korea [KSN2021210]; Pink Ribbon
   [207697-2019]
FX T.Y. Choi, L.A., J.H.J. and M.S.L. were supported by the Korea Institute
   of Oriental Medicine, Korea (KSN2021210). T.A. is the PI of an ongoing
   study that is funded by a grant from Pink Ribbon, which is a
   collaboration between The Norwegian Cancer Association and the Breast
   Cancer Society (Contract no.: 207697-2019). The funder had no role in
   the study design, the data collection and analysis, the decision to
   publish, or the preparation of the manuscript.
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NR 44
TC 16
Z9 20
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAY
PY 2022
VL 14
IS 10
AR 2347
DI 10.3390/cancers14102347
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 1P2US
UT WOS:000801870800001
PM 35625952
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, GW
   Chen, J
   Huang, YM
   Pan, CB
   Chen, WL
   Zhang, SM
   Lin, W
   Liu, XX
   Wu, MX
AF Wu Guang-wen
   Chen Jun
   Huang Yun-mei
   Pan Cai-bin
   Chen Wen-lie
   Zhang Shi-mao
   Lin Wei
   Liu Xian-xiang
   Wu Ming-xia
TI Electroacupuncture Delays Cartilage Degeneration by Modulating Nuclear
   Factor-κB Signaling Pathway
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE osteoarthritis; electroacupuncture; synovial fluid; cartilage;
   cytokines; nuclear factor-kappa B signaling pathway
ID TUMOR-NECROSIS-FACTOR; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE;
   EXPRESSION; ALPHA; PAIN; DIFFERENTIATION; PATHOGENESIS; ACUPUNCTURE;
   MECHANISMS
AB Objective To illustrate the molecular mechanisms underlying the therapeutic effects of electroacupuncture (EA) on knee osteoarthritis (OA). Methods Twenty-seven six-month-old New Zealand white rabbits were allocated into three groups in accordance with a random number table: normal group (no surgery-induced OA; without treatment), model group (surgery-induced OA; without treatment) and EA group [surgery-induced OA; received treatment with EA at acupoints Dubi (ST 35) and Neixiyan (EX-LE 5), 30 min twice a day]. After eight consecutive weeks of treatment, the histopathological alterations in cartilage were observed using optical microscopy and transmission electron microscopy, cartilage degeneration was evaluated by modified Mankin's score principles, the synovial fluid concentration of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-3 (MMP-3) were evaluated by enzyme-linked immunosorbent assay, and the protein expression levels of IL-1 beta, IL-6, TNF-alpha, MMP-3, I kappa B kinase-beta (IKK-beta), nuclear factor of alpha light polypeptide gene enhancer in B-cells inhibitor alpha (I kappa B-alpha) and nuclear factor-kappa B (NF-kappa B) p65 were quantified by Western blot analysis. Results EA treatment significantly improved cartilage structure arrangement and reduced cellular degeneration. The IL-1 beta, IL-6, TNF-alpha and MMP-3 of synovial fluid in the EA-treated group were significantly decreased compared with the model group (all P<0.01). Compared with the model group, the IL-1 beta, IL-6, TNF-alpha, MMP-3, IKK-beta and NF-kappa B p65 protein expressions in cartilage of EA-treated group were significantly decreased (all P<0.01), whereas I kappa B-alpha expression was significantly up-regulated (P<0.01). Conclusion EA treatment may delay cartilage degeneration by down-regulating inflammatory factors through NF-kappa B signaling pathway, which may, in part, explain its clinical efficacy in the treatment of knee OA.
C1 [Wu Guang-wen; Chen Jun; Huang Yun-mei; Pan Cai-bin; Chen Wen-lie; Liu Xian-xiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Fujian, Peoples R China.
   [Zhang Shi-mao] Fujian Xiangxing Elect Technol Co Ltd, Ningde 352300, Fujian, Peoples R China.
   [Lin Wei] Fujian Prov Key Lab Integrat Med Geriatr, Fuzhou 350122, Fujian, Peoples R China.
   [Wu Ming-xia] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp 2, Dept Acupuncture, Fuzhou 350003, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Wu, MX (corresponding author), Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp 2, Dept Acupuncture, Fuzhou 350003, Fujian, Peoples R China.
EM wumingxiafz@163.com
FU National Natural Science Foundation of China [81373719]; Project of
   Fujian Provincial Development and Reform Commission [2014-514]; Major
   Project of Fujian Provincial Department of Science and Technology Agency
   [2013Y4003]
FX Supported by National Natural Science Foundation of China (No.
   81373719), Project of Fujian Provincial Development and Reform
   Commission (No. 2014-514), Major Project of Fujian Provincial Department
   of Science and Technology Agency (No. 2013Y4003)
CR Ahmed S, 2005, EVID-BASED COMPL ALT, V2, P301, DOI 10.1093/ecam/neh117
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NR 35
TC 25
Z9 27
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD SEP
PY 2019
VL 25
IS 9
BP 677
EP 683
DI 10.1007/s11655-018-2916-8
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA JG9RI
UT WOS:000492413300006
PM 30656598
DA 2026-01-16
ER

PT J
AU Kwon, KK
   Lacey, J
   Kerin-Ayres, K
   Heller, G
   Grant, S
AF Kwon, Ki Kyung
   Lacey, Judith
   Kerin-Ayres, Kim
   Heller, Gillian
   Grant, Suzanne
TI Acupuncture for the treatment of the pain-fatigue-sleep
   disturbance-numbness/tingling symptom cluster in breast cancer
   survivors: a feasibility trial
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Acupuncture; Integrative oncology; Cancer; Symptom clusters; Model
   validity
ID PSYCHOLOGICAL DISTRESS; MANAGEMENT; ELECTROACUPUNCTURE; INTERVENTIONS;
   NETWORK
AB Purpose Breast cancer survivors following disease-modifying treatment frequently experience multiple-concurrent symptoms (Jansana et al. in Int J Cancer 149(10):1755 1767, 2021), negatively impacting their quality of life and increasing the risk of polypharmacy (Alwhaibi et al. in J Oncol Pharm Pract 26(5):1052 1059, 2020). This study evaluates the feasibility and acceptability of acupuncture for the management of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster in breast cancer survivors, and investigates relationships between the symptom cluster and Traditional Chinese Medicine (TCM) syndrome diagnosis. Methods This was a single-arm, pre-test/post-test feasibility trial conducted at Chris O'Brien Lifehouse Hospital, Australia. Breast cancer survivors who completed treatment and experienced clinically significant levels of two or more symptoms (pain, fatigue, sleep disturbance, numbness/tingling) were eligible to participate in the individualized, pragmatic 6-week acupuncture intervention. The primary outcome was feasibility and acceptability. Effectiveness was explored using a symptom cluster mean score. Results Twenty women enrolled in the study over an 11-week period and 90% completed the study. Most women agreed or completely agreed that acupuncture was feasible (85%), acceptable (90%), and appropriate (90%). Both mean and composite symptom cluster scores were significantly reduced (p < 0.001), as were individual symptom scores in fatigue (p < 0.001), sleep disturbance (p = 0.04), and numbness/tingling (p = 0.01). TCM syndromes most closely associated with this symptom cluster were Spleen qi deficiency and Heart fire. No adverse events were reported. Conclusion This study demonstrated that acupuncture was safe and feasible, justifying a powered randomized control trial. Preliminary findings suggest beneficial effects of acupuncture for the management of the pain-fatigue-sleep disturbance-numbness/tingling symptom cluster for women with breast cancer. TCM syndromes identified in this trial may be used to guide acupuncture treatment protocols.
C1 [Kwon, Ki Kyung; Lacey, Judith; Grant, Suzanne] Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Kwon, Ki Kyung; Lacey, Judith; Kerin-Ayres, Kim; Heller, Gillian; Grant, Suzanne] Chris OBrien Lifehouse Hosp, Camperdown, NSW, Australia.
   [Lacey, Judith; Heller, Gillian] Univ Sydney, Camperdown, NSW, Australia.
C3 Western Sydney University; Chris O'Brien Lifehouse; University of Sydney
RP Kwon, KK (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.; Kwon, KK (corresponding author), Chris OBrien Lifehouse Hosp, Camperdown, NSW, Australia.
EM ki.kwon@lh.org.au; Kim.kerinayres@health.nsw.gov.au
RI ; Lacey, Judith/AAI-5754-2021; Grant, Suzanne Jane/JTT-6993-2023
OI Heller, Gillian/0000-0003-1270-1499; Lacey, Judith/0000-0002-3751-406X;
   Grant, Suzanne Jane/0000-0002-9491-203X; Kwon, Ki
   Kyung/0009-0007-1295-8549
FU Western Sydney University
FX No Statement Available
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NR 45
TC 4
Z9 4
U1 3
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUN
PY 2024
VL 32
IS 6
AR 332
DI 10.1007/s00520-024-08529-9
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA PQ7P6
UT WOS:001215617300002
PM 38713422
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Wang, JS
   Lei, Y
   Bao, BH
   Yu, XD
   Dai, HH
   Chen, F
   Li, HS
   Wang, B
AF Wang, Jisheng
   Lei, Yi
   Bao, Binghao
   Yu, Xudong
   Dai, Hengheng
   Chen, Fei
   Li, Haisong
   Wang, Bin
TI Acupuncture for pain caused by prostate cancer Protocol for a systematic
   review
SO MEDICINE
LA English
DT Review
DE acupuncture; pain; protocol; prostate cancer; systematic review
ID ANALGESIA
AB Background: Prostate cancer is a male malignant tumor disease with high prevalence in recent years. Patients with advanced prostate cancer are more likely to have bone metastasis and strong bone pain, and even lead to pathological fracture, which has a serious impact on the quality of life of patients. Acupuncture has good clinical efficacy in treating pain caused by prostate cancer. This review hopes to adopt meta-analysis to evaluate the efficacy and safety of acupuncture in the treatment of pain caused by prostate cancer and provides evidence for its application in clinical practice.
   Methods and analysis: We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet, Nature, Science online and China Journal Full-text Database (CNKI), China Biomedical Literature CD-ROM Database (CBM), and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to November 2018. We will use the criteria provided by Cochrane 5.1.0 for quality assessment and risk assessment of the included studies, and use the Revman 5.3 and Stata 13.0 software for meta-analysis of the effectiveness, recurrence rate, and symptom scores of epididymitis.
   Ethics and dissemination: This systematic review will evaluate the efficacy and safety of acupuncture for pain caused by prostate cancer. Owing to the fact that all of the data used in this systematic review and meta-analysis have been published, this review does not require ethical approval. Furthermore, all data will be anonymously analyzed during the review process trial.
C1 [Wang, Jisheng; Bao, Binghao; Yu, Xudong; Dai, Hengheng] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Wang, Jisheng; Bao, Binghao; Yu, Xudong; Dai, Hengheng; Chen, Fei; Li, Haisong; Wang, Bin] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Androl, Beijing, Peoples R China.
   [Lei, Yi] Shaanxi Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Androl, Xianyang, Shaanxi, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Shaanxi University of Chinese Medicine
RP Li, HS; Wang, B (corresponding author), Dongzhimen Hosp, Dept Androl, Hai Yun Cang 5th ZIP, Beijing 100029, Peoples R China.
EM 1028bj@sina.com; dayiwangbin@sina.com
FU 2016 Beijing Chinese Medicine Salary Heritage 3+3 Project
   [2016-SZ-C-60]; Young Scientist Development Program 2016, Dongzhimen
   Hospital Affiliated to Beijing University of Chinese Medicine
   [DZMYS-201609]
FX The work is supported by 2016 Beijing Chinese Medicine Salary Heritage
   3+3 Project (2016-SZ-C-60). It was also supported by the Young Scientist
   Development Program 2016, Dongzhimen Hospital Affiliated to Beijing
   University of Chinese Medicine (No. DZMYS-201609).
CR [Anonymous], 2013, CHINA CANC
   [Anonymous], EUR UROL S
   [Anonymous], 2017, CHINJ ONCOL PREVENT
   [Anonymous], 2018, CHIN J MODER DRUG AP
   [Anonymous], 2010, ACTA CHIN MED PHARM
   [Anonymous], 2013, CANC PROGR
   Braunhut Beth L, 2018, Surg Pathol Clin, V11, P759, DOI [10.1016/j.path.2018.07.003, 10.1016/j.path.2018.07.003]
   Chao Y, 2015, J SHANGHAI U TRADIT, V29, P26
   Chen Zhong-jie, 2008, Zhongguo Zhen Jiu, V28, P392
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NR 26
TC 5
Z9 7
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 2
AR e13954
DI 10.1097/MD.0000000000013954
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3CX
UT WOS:000462286300025
PM 30633174
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU He, YH
   Liu, YH
   May, BH
   Zhang, AL
   Zhang, HB
   Lu, CJ
   Yang, LH
   Guo, XF
   Xue, CC
AF He, Yihan
   Liu, Yihong
   May, Brian H.
   Zhang, Anthony Lin
   Zhang, Haibo
   Lu, ChuanJian
   Yang, Lihong
   Guo, Xinfeng
   Xue, Charlie Changli
TI Effectiveness of acupuncture for cancer pain: protocol for an umbrella
   review and meta-analyses of controlled trials
SO BMJ OPEN
LA English
DT Review
ID QUALITY-OF-LIFE; TRADITIONAL CHINESE MEDICINE; RANDOMIZED
   CONTROLLED-TRIAL; BREAST-CANCER; SYMPTOM MANAGEMENT; SYSTEMATIC REVIEWS;
   CLINICAL-RESEARCH; PALLIATIVE CARE; ARTHRALGIA; GUIDELINES
AB Introduction The National Comprehensive Cancer Network guidelines for adult cancer pain indicate that acupuncture and related therapies may be valuable additions to pharmacological interventions for pain management. Of the systematic reviews related to this topic, some concluded that acupuncture was promising for alleviating cancer pain, while others argued that the evidence was insufficient to support its effectiveness.
   Methods and analysis This review will consist of three components: (1) synthesis of findings from existing systematic reviews; (2) updated meta-analyses of randomised clinical trials and (3) analyses of results of other types of clinical studies. We will search six English and four Chinese biomedical databases, dissertations and grey literature to identify systematic reviews and primary clinical studies. Two reviewers will screen results of the literature searches independently to identify included reviews and studies. Data from included articles will be abstracted for assessment, analysis and summary. Two assessors will appraise the quality of systematic reviews using Assessment of Multiple Systematic Reviews; assess the randomised controlled trials using the Cochrane Collaboration's risk of bias tool and other types of studies according to the Newcastle-Ottawa Scale. We will use 'summary of evidence' tables to present evidence from existing systematic reviews and meta-analyses. Using the primary clinical studies, we will conduct meta-analysis for each outcome, by grouping studies based on the type of acupuncture, the comparator and the specific type of pain. Sensitivity analyses are planned according to clinical factors, acupuncture method, methodological characteristics and presence of statistical heterogeneity as applicable. For the non-randomised studies, we will tabulate the characteristics, outcome measures and the reported results of each study. Consistencies and inconsistencies in evidence will be investigated and discussed. Finally, we will use the Grading of Recommendations Assessment, Development and Evaluation approach to evaluate the quality of the overall evidence.
   Ethics and dissemination There are no ethical considerations associated with this review. The findings will be disseminated in peer-reviewed journals or conference presentations.
C1 [He, Yihan; Liu, Yihong; May, Brian H.; Zhang, Anthony Lin; Zhang, Haibo; Lu, ChuanJian; Yang, Lihong; Guo, Xinfeng; Xue, Charlie Changli] RMIT Univ, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.
   [He, Yihan; Liu, Yihong; Zhang, Haibo; Lu, ChuanJian; Yang, Lihong; Guo, Xinfeng; Xue, Charlie Changli] Guangdong Prov Hosp Chinese Med, Guangdong Prov Acad Chinese Med Sci, Guangzhou, Guangdong, Peoples R China.
   [He, Yihan; Liu, Yihong; Zhang, Haibo; Lu, ChuanJian; Yang, Lihong; Guo, Xinfeng; Xue, Charlie Changli] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China.
C3 Royal Melbourne Institute of Technology (RMIT); Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Guo, XF; Xue, CC (corresponding author), RMIT Univ, China Australia Int Res Ctr Chinese Med, Melbourne, Vic, Australia.; Guo, XF; Xue, CC (corresponding author), Guangdong Prov Hosp Chinese Med, Guangdong Prov Acad Chinese Med Sci, Guangzhou, Guangdong, Peoples R China.; Guo, XF; Xue, CC (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China.
EM drguoxinfeng@163.com; charlie.xue@rmit.edu.au
RI Xue, Charlie C/F-1244-2014; Guo, Xinfeng/AAM-6850-2021; Zhang, Anthony
   Lin/AAR-6673-2021; Zhang, Haibo/HLP-9266-2023
OI Xue, Charlie C/0000-0001-6937-9088; Guo, Xinfeng/0000-0003-2699-9740;
   Zhang, Anthony Lin/0000-0002-0968-9380; 
FU Guangdong Provincial Academy of Chinese Medical Sciences, China; RMIT
   University through China-Australia International Research Centre for
   Chinese Medicine; School of Health and Biomedical Sciences, RMIT
   University
FX Guangdong Provincial Academy of Chinese Medical Sciences, China, and
   RMIT University through the China-Australia International Research
   Centre for Chinese Medicine as well as PhD scholarship support to the
   first author provided by the School of Health and Biomedical Sciences,
   RMIT University.
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NR 94
TC 14
Z9 16
U1 0
U2 34
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2017
VL 7
IS 12
AR e018494
DI 10.1136/bmjopen-2017-018494
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FU4MH
UT WOS:000423826700141
PM 29229658
OA Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Chen, ZW
   Xu, T
   Yin, ZH
   Li, QF
   Shu, YJ
   Zhou, XL
   Zhao, L
   Sun, MS
   Liang, FR
AF Chen, Zi-Wen
   Xu, Tao
   Yin, Zi-Han
   Li, Qi-fu
   Shu, Yun-Jie
   Zhou, Xue-Li
   Zhao, Ling
   Sun, Ming-Sheng
   Liang, Fan-Rong
TI Electroacupuncture for chemotherapy-induced gastrointestinal symptoms in
   colorectal cancer: protocol for a multicenter, three-arm, randomized
   controlled trial
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Chemotherapy; Gastrointestinal toxicity; Colorectal cancer;
   Electroacupuncture; Randomized controlled trial
ID ACUPUNCTURE; INFLAMMATION; PATHWAY
AB BackgroundColorectal cancer (CRC) is the second leading cause of cancer-related mortality globally. While chemotherapy remains a cornerstone of CRC treatment, gastrointestinal (GI) toxicity-manifesting as abdominal pain, diarrhea, constipation, and reflux-affects 40%-100% of patients, severely impairing quality of life. Despite the prevalence of these symptoms, there is a lack of effective non-pharmacological interventions. This study aims to evaluate the efficacy of electroacupuncture (EA) in alleviating chemotherapy-induced GI dysfunction in CRC patients.MethodsIn this multicenter, three-arm, randomized controlled trial (RCT), 231 CRC patients with post-chemotherapy GI symptoms will be centrally randomized to EA plus standard care, sham acupuncture (SA) plus standard care, or standard care alone. The EA and SA groups will receive three 30-min sessions over consecutive days, delivered by certified acupuncturists (EA: LI11, PC6, ST36 and ST37 with electrical stimulation; SA: non-acupoints with blunt-tip needles without stimulation). The primary outcome is the change in Gastrointestinal Symptom Rating Scale (GSRS) total scores from baseline to post-treatment (day 3). Secondary outcomes include GSRS subscale scores, Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scores, and Self-Rating Anxiety Scale/Self-Rating Depression Scale (SAS/SDS) scores. All outcomes will be assessed at baseline (T0), post-intervention (T1: day 3), and follow-up (T2: day 10). Statistical analysis will employ intention-to-treat linear mixed-effects models.ConclusionThis multicenter RCT is designed to generate high-quality evidence on the comprehensive efficacy of EA in addressing chemotherapy-induced GI toxicity in CRC patients. If proven effective, EA could provide a safe, non-pharmacological adjunct to standard care, helping to reduce symptom burden and improve patient adherence to chemotherapy.Trial registration ChiCTR2200062317. Registered on 1 August 2022.ConclusionThis multicenter RCT is designed to generate high-quality evidence on the comprehensive efficacy of EA in addressing chemotherapy-induced GI toxicity in CRC patients. If proven effective, EA could provide a safe, non-pharmacological adjunct to standard care, helping to reduce symptom burden and improve patient adherence to chemotherapy.Trial registration ChiCTR2200062317. Registered on 1 August 2022.
C1 [Chen, Zi-Wen; Yin, Zi-Han; Li, Qi-fu; Shu, Yun-Jie; Zhou, Xue-Li; Zhao, Ling; Sun, Ming-Sheng; Liang, Fan-Rong] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China.
   [Chen, Zi-Wen; Yin, Zi-Han; Sun, Ming-Sheng; Liang, Fan-Rong] Sichuan Prov Acupuncture Clin Med Res Ctr, Chengdu, Sichuan, Peoples R China.
   [Xu, Tao] Sichuan Orthoped Hosp, Res Dept, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Liang, FR (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China.; Liang, FR (corresponding author), Sichuan Prov Acupuncture Clin Med Res Ctr, Chengdu, Sichuan, Peoples R China.
EM sunmingsheng@163.com; acuresearch@126.com
RI chen, ziwen/JRZ-1387-2023; Zihan, Yin/HNI-0959-2023
FU Major Project of Sichuan Provincial Department of Science and Technology
FX Not Applicable.
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NR 33
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD OCT 27
PY 2025
VL 40
IS 1
AR 221
DI 10.1007/s00384-025-05008-3
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 8ZF1J
UT WOS:001600839900001
PM 41144022
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Lin, LL
   Li, HP
   Yang, JW
   Hao, XW
   Yan, SY
   Wang, LQ
   Yu, FT
   Shi, GX
   Liu, CZ
AF Lin, Lu-Lu
   Li, Hong-Ping
   Yang, Jing-Wen
   Hao, Xiao-Wan
   Yan, Shi-Yan
   Wang, Li-Qiong
   Yu, Fang-Ting
   Shi, Guang-Xia
   Liu, Cun-Zhi
TI Acupuncture for Psychological Disorders Caused by Chronic Pain: A Review
   and Future Directions
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE acupuncture; chronic pain; psychological states; review; clinical
   trials; biological mechanisms
ID ANTERIOR CINGULATE CORTEX; DORSAL RAPHE NUCLEUS; LOW-BACK-PAIN;
   TENSION-TYPE HEADACHE; QUALITY-OF-LIFE; CONTROLLED-TRIAL; DOPAMINE
   SYSTEM; SHOULDER PAIN; DEPRESSION; MANAGEMENT
AB Accumulating evidence supports an association between chronic pain and psychological disorders, a connection that seems to be bidirectional. Treating both the pain and psychological conditions together is essential for effective treatment outcomes. Acupuncture is a somatosensory-guided mind-body therapy that can tackle the multidimensional nature of pain with fewer or no serious adverse effects. In this review, we discuss the use of acupuncture in some conditions with a high incidence of psychological disorders caused by chronic pain: headache, musculoskeletal pain, low back pain, and cancer pain, focusing on the effect and potential mechanisms of acupuncture. Overall clinical studies indicated that acupuncture might effectively contribute to management of psychological disorders caused by chronic pain. Mechanistic studies showed that acupuncture significantly alleviated such psychological disorders by regulating the activity of amygdala and insula, and regulating functional connectivity of insular and limbic regions/medial prefrontal cortex in humans and the corresponding animal models. In addition, 5-HT in the dorsal raphe nucleus, opioid receptors in the cingulate cortex, and plasma met-enkephalin are involved in acupuncture relief of pain and psychological symptoms. Substantial evidences from animal and human research support a beneficial effect of acupuncture in psychological disorders caused by chronic pain.
C1 [Lin, Lu-Lu; Li, Hong-Ping; Yang, Jing-Wen; Hao, Xiao-Wan; Yan, Shi-Yan; Wang, Li-Qiong; Yu, Fang-Ting; Shi, Guang-Xia; Liu, Cun-Zhi] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Beijing, Peoples R China.
   [Lin, Lu-Lu; Li, Hong-Ping; Yang, Jing-Wen; Hao, Xiao-Wan; Yan, Shi-Yan; Wang, Li-Qiong; Yu, Fang-Ting; Shi, Guang-Xia; Liu, Cun-Zhi] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Shi, GX (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Beijing, Peoples R China.; Shi, GX (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
EM shiguangxia2008@126.com
RI Yan, Shiyan/J-7224-2013; Yu, Fang-Ting/HIK-3174-2022; li,
   hongping/JBR-8611-2023; Lin, Lulu/JSL-6136-2023
FU National Key R&D Program of China [2019YFC1712100]
FX This work was supported by funds from the National Key R&D Program of
   China (2019YFC1712100).
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NR 96
TC 15
Z9 20
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JAN 27
PY 2021
VL 14
AR 626497
DI 10.3389/fnins.2020.626497
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA QE9EL
UT WOS:000616506700001
PM 33584181
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Sun, D
   Chang, HY
   Luo, DC
   Du, GC
   Wang, H
   Yan, B
AF Sun, Di
   Chang, Hongyuan
   Luo, Dicheng
   Du, Guanchao
   Wang, Hao
   Yan, Bin
TI A narrative review of acupuncture in prostate diseases: perspectives
   from traditional Chinese medicine, current evidence and future
   directions
SO REVISTA INTERNACIONAL DE ANDROLOGIA
LA English
DT Review
DE Acupuncture; Prostate diseases; Chronic prostatitis/chronic pelvic pain
   syndrome; Benign prostatic hyperplasia; Prostate cancer; Traditional
   Chinese medicine
ID PELVIC PAIN SYNDROME; VASOMOTOR SYMPTOMS; HOT FLUSHES; MEN;
   ELECTROACUPUNCTURE; CANCER; HYPERPLASIA; EFFICACY; INFLAMMATION;
   EXPRESSION
AB Prostate diseases, including chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), benign prostatic hyperplasia (BPH) and prostate cancer, are among the most common conditions in andrology and urology. These diseases significantly affect patients' life quality and have profound impacts on the mental and psychological health of patients. Acupuncture has been widely used to treat prostate diseases, demonstrating notable efficacy and safety. This review synthesizes traditional Chinese medicine (TCM) perspectives on prostate diseases and evaluates the clinical application of acupuncture while summarizing mechanisms and proposing future research directions. Our review included twenty clinical trials involving CP/CPPS, BPH and prostate cancer. Acupuncture demonstrates significant efficacy in symptom relief (pain reduction and improvement of urinary symptoms) and disease modification (prostate volume reduction). The most frequently targeted meridians were the bladder meridian of foot-taiyang, the spleen meridian of foot-taiyin, ren meridian, the pericardium meridian of hand-jueyin, the liver meridian of foot-jueyin, the heart meridian of handshaoyin, the gallbladder meridian of foot-shaoyang and the kidney meridian of footshaoyin. In addition, acupuncture treatment for each disease exhibited distinct TCM characteristics and mechanisms of action. Patients with prostate disease may benefit from acupuncture treatment, however, high-quality clinical evidence, standardized guidelines and exploration of the mechanisms of acupuncture for prostate diseases are needed in the future.
C1 [Sun, Di; Chang, Hongyuan; Luo, Dicheng; Du, Guanchao; Wang, Hao; Yan, Bin] Chinese Med Sci, Xiyuan Hosp China Acad, Dept Androl, Beijing 100091, Peoples R China.
   [Sun, Di] Chongqing Univ, Three Gorges Hosp, Dept Androl, Chongqing 404000, Peoples R China.
C3 Chongqing University
RP Wang, H; Yan, B (corresponding author), Chinese Med Sci, Xiyuan Hosp China Acad, Dept Androl, Beijing 100091, Peoples R China.
EM wanghao0066@126.com; yanbinxyyy@126.com
RI luo, dicheng/PGF-4263-2026; Chang, Hongyuan/OEN-6121-2025
FU State Administration of Traditional Chinese Medicine High-level Key
   Discipline Construction Project [zyyzdxk-2023238]; Capacity Enhancement
   Project of Xiyuan Hospital, China Academy of Traditional Chinese
   Medicine [XYZX0405-31]
FX This work was financed by the State Administration of Traditional
   Chinese Medicine High-level Key Discipline Construction Project (No.
   zyyzdxk-2023238) and Capacity Enhancement Project of Xiyuan Hospital,
   China Academy of Traditional Chinese Medicine (XYZX0405-31) .
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NR 77
TC 0
Z9 0
U1 0
U2 0
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1698-031X
J9 REV INT ANDROL
JI Rev. Int. Androl.
PD SEP
PY 2025
VL 23
IS 3
BP 22
EP 33
DI 10.22514/j.androl.2025.027
PG 12
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8NN1L
UT WOS:001592887000002
DA 2026-01-16
ER

PT J
AU Gavronsky, S
   Koeniger-Donohue, R
   Steller, J
   Hawkins, JW
AF Gavronsky, Stas
   Koeniger-Donohue, Rebecca
   Steller, Julie
   Hawkins, Joellen W.
TI Postoperative Pain: Acupuncture versus Percutaneous Electrical Nerve
   Stimulation
SO PAIN MANAGEMENT NURSING
LA English
DT Article
ID LOW-BACK-PAIN; REPRODUCTIVE HEALTH-CARE; VISUAL ANALOG SCALES;
   CONTROLLED-TRIAL; ELECTROACUPUNCTURE; QUESTIONNAIRE; MANAGEMENT; THERAPY
AB The purpose of this study was to examine the effect of traditional acupuncture compared with acupuncture with percutaneous electrical nerve stimulation (PENS) on postoperative surgical pain relief in gynecologic oncology patients. Twenty postoperative gynecologic oncology patients were randomly assigned into the two groups, and the intervention was initiated within 24 hours after surgery. The patients in each group received four treatments in the subsequent 48 hours, with 12 hours between each-treatment. Either traditional acupuncture needles or acupuncture needles with a pulsed electric current were applied to stimulate the area of points Sp6 and Sp8 near the saphenous nerve. Pain measurement instruments included a visual analog scale and the McGill Pain Questionnaire. Although the PENS treatment group demonstrated a consistent decrease in pain with each treatment application compared with the traditional acupuncture group, after 48 hours both groups experienced equivalent pain relief. (C) 2012 by the American Society for Pain Management Nursing
C1 [Gavronsky, Stas; Koeniger-Donohue, Rebecca; Steller, Julie; Hawkins, Joellen W.] Simmons Coll, Sch Hlth Sci, Boston, MA 02115 USA.
C3 Simmons University
RP Koeniger-Donohue, R (corresponding author), Simmons Coll, Sch Hlth Sci, 300 Fenway, Boston, MA 02115 USA.
EM rdono1@gmail.com
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NR 34
TC 21
Z9 24
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD SEP
PY 2012
VL 13
IS 3
BP 150
EP 156
DI 10.1016/j.pmn.2009.08.001
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 005YH
UT WOS:000308785500004
PM 22929602
DA 2026-01-16
ER

PT J
AU Wang, YX
   Zhang, JY
   Jin, YX
   Zhang, Q
AF Wang, Yunxia
   Zhang, Jiayuan
   Jin, Yuxia
   Zhang, Qi
TI Auricular Acupressure Therapy for Patients with Cancer with Sleep
   Disturbance: A Systematic Review and Meta-Analysis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; POINT ACUPRESSURE; RECEIVING CHEMOTHERAPY;
   INSOMNIA; MELATONIN; FATIGUE
AB Aim. We aim to provide available synthesized evidence of the efficacy and safety of auricular acupressure for cancer patients with sleep disturbance. Methods. Randomized controlled clinical trials (RCTs) were identified from PubMed, EMBASE, Web of Science, The Cochrane Library, PsycINFO, Chinese Biomedical Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data, and the search date ranged from the inception of the databases to May 2021. Literature screening and data extraction were independently performed by three researchers. The Cochrane collaboration's tool for assessing the risk of bias was applied to evaluate the risk of bias of the RCTs included. The extracted data were analyzed using Rev-Man 5.4.1 software. Results. Nine trials involving 688 participants met the inclusion criteria and were included in the qualitative analysis; 6 trials involving 485 participants were included in the meta-analysis. Synthesized results showed that auricular acupressure had a significant effect on reducing the total Pittsburgh Sleep Quality Index (PSQI) score (MD = -3.88, 95% CI (-5.24, -2.53), P<0.00001), and the scores of five PSQI components, sleep latency (MD = -0.53, 95% CI (-0.73, -0.32), P<0.00001), subjective sleep quality (MD = -0.79, 95% CI (-1.05, -0.53), P<0.00001), sleep duration (MD = -0.50, 95% CI (-0.69, -0.31), P<0.0001), daytime dysfunction (MD = -0.53, 95% CI (-0.77, -0.29), P<0.0001), and sleep disturbances (MD = -0.54, 95% CI (-0.60, -0.49), P<0.00001), were also obviously decreased after the intervention of auricular acupressure. Shenmen and heart were the most commonly selected auricular acupoints, the main intervention durations ranged from 10 to 42 days, and the pressing times of auricular acupoints were 1-6 times a day, 1-5 min each time. One trial reported slight and transient pain caused by auricular acupressure, while the remaining 8 trials did not report obvious side effects. Conclusion. Auricular acupressure can significantly improve the sleep quality of cancer patients with sleep disturbance, with no obvious side effects. Rigorously designed clinical trials are necessary for the further support of the clinical application.
C1 [Wang, Yunxia; Zhang, Jiayuan; Jin, Yuxia; Zhang, Qi] Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, Q (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
EM zhangqi@cdutcm.edu.cn
FU National Natural Science Foundation of China [81873222]
FX AcknowledgmentsThis work was supported by the National Natural Science
   Foundation of China (no. 81873222).
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NR 51
TC 32
Z9 38
U1 2
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD OCT 14
PY 2021
VL 2021
AR 3996101
DI 10.1155/2021/3996101
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA XB8SB
UT WOS:000721591700001
PM 34691214
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Turan, GB
   Özer, Z
   Yanmis, S
   Aksoy, A
AF Bahcecioglu Turan, Gulcan
   Ozer, Zulfunaz
   Yanmis, Safiye
   Aksoy, Asude
TI The Effects of Self-Acupressure on Pain, Fatigue, and Sleep Quality in
   Colon and Pancreatic Cancer Patients Receiving Chemotherapy
SO CANCER NURSING
LA English
DT Article
DE Colon cancer; Fatigue; Insomnia; Nurse; Pain; Pancreatic cancer;
   Self-acupressure
ID AURICULAR POINT ACUPRESSURE; RANDOMIZED CONTROLLED-TRIAL; SYMPTOM
   MANAGEMENT; CLUSTERS
AB BackgroundPancreatic and colon cancer are among important gastrointestinal cancer diseases. Pain, fatigue, and insomnia are among the most common symptoms in cancer patients receiving chemotherapy. Self-acupressure may improve patients' pain, fatigue, sleep quality, quality of life, and functional well-being.ObjectiveThe aim of this study was to examine the effects of self-acupressure application on pain, fatigue, and sleep quality in colon and pancreatic cancer patients receiving chemotherapy.MethodsThis randomized controlled study was conducted with 60 patients in treatment for pancreatic or colon cancer, 30 in the intervention and 30 in the control group, between June and October 2021. Participants in the intervention group were asked to complete 16 acupressure sessions for 4 weeks, 2 days a week in the morning and afternoon for a total of 18 minutes, depending on the preparation and pressure time on 4 pressure points. Control group participants did not receive any interventions during the study. The data were collected by using a personal information form, the Pittsburgh Sleep Quality Index, the Piper Fatigue Scale, and the visual analog scale.ResultsAfter self-acupressure, the visual analog scale, Piper Fatigue Scale, and Pittsburgh Sleep Quality Index scores of the intervention group decreased when compared with the control group scores; the difference between the 2 groups was statistically significant.ConclusionSelf-acupressure was effective in reducing the pain, fatigue, and sleep disorder scores of patients with colon or pancreatic cancer receiving chemotherapy.Implications for PracticeIn nursing practice, self-acupressure, an applicable, accessible, and inexpensive method in the management of cancer-related symptoms, can be supported and maintained during a 4-week period.
C1 [Bahcecioglu Turan, Gulcan] Firat Univ, Fac Hlth Sci, Dept Nursing, Elazig, Turkiye.
   [Ozer, Zulfunaz] Istanbul Sabahattin Zaim Univ, Fac Hlth Sci, Elazig, Turkiye.
   [Yanmis, Safiye] Erzican Binali Yildirim Univ, Fac Hlth Sci, Dept Nursing, Elazig, Turkiye.
   [Aksoy, Asude] Firat Univ, Dept Internal Med, Med Sch, Elazig, Turkiye.
   [Bahcecioglu Turan, Gulcan] Firat Univ, Fac Hlth Sci, Dept Nursing, Rectorate Campus,Exterior Door 2, TR-23200 Center Elazig, Turkiye.
C3 Firat University; Istanbul Sabahattin Zaim University; Firat University;
   Firat University
RP Turan, GB (corresponding author), Firat Univ, Fac Hlth Sci, Dept Nursing, Rectorate Campus,Exterior Door 2, TR-23200 Center Elazig, Turkiye.
EM glcnbah@hotmail.com; zulfinazozer@gmail.com; safiyeyanmis61@gmail.com;
   asudeaksoy@hotmail.com
RI ozer, zulfunaz/GQP-7883-2022; Bahçecioğlu Turan, Gülcan/V-4343-2017
OI Bahçecioğlu Turan, Gülcan/0000-0002-0061-9490
FU The authors are grateful to all participants who agreed to participate
   voluntarily in this study.
FX The authors are grateful to all participants who agreed to participate
   voluntarily in this study.
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NR 55
TC 7
Z9 8
U1 5
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD NOV-DEC
PY 2023
VL 46
IS 6
BP 457
EP 466
DI 10.1097/NCC.0000000000001193
PG 10
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA W2IA2
UT WOS:001089906600013
DA 2026-01-16
ER

PT J
AU Carvalho, FS
   Carvalho, S
   Conde, R
   Esteves, S
AF Carvalho, Filipe Silva
   Carvalho, Susana
   Conde, Rita
   Esteves, Susana
TI Cynotherapy in Cancer Pain Management: A Pilot Study
SO PAIN MEDICINE
LA English
DT Article
DE Oncological Pain; Pain Management; Emotional Distress; Therapy Dog;
   Animal Assisted Therapy
ID ANIMAL-ASSISTED THERAPY; PET-THERAPY; IMPROVE; HEALTH; DOGS;
   INTERVENTION; SATISFACTION; GUIDELINES; PATHOGENS; DISTRESS
AB Objectives. This was a pilot study to evaluate the feasibility and impact of a single dog-assisted therapy (cynotherapy) session in reducing pain and emotional distress in oncological outpatients compared with typical waiting room experience (control). Design. This was a quasi-experimental before-after controlled study that took place at a chronic pain outpatient clinic of a tertiary cancer center, whose participants were adult oncological patients, able to consent and without medical contraindication. Setting. Chronic pain outpatient clinic of a tertiary cancer center. Participants. Adult oncological patients able to consent and without medical contraindication. Methods. All participants completed self-reported questionnaires including a numeric rating scale for pain and distress thermometer at admission and immediately before departure from the clinic. Results. Eighty-one patients were enrolled over a 10-month study period, 41 in the cynotherapy group and 40 controls. Improvement was greater in cynotherapy than control group for pain (median difference score = -1.0 vs 0.0; P = 0.037), distress levels (median = -1.0 vs 0.0; P = 0.017), and depression (median = -1.0 vs 0.0; P = 0.030). The proportion of patients with a clinically relevant improvement in pain (reduction >= 2 points) was approximately twofold in the cynotherapy group when compared with controls, although not statistically significant (39% vs 20%, odds ratio = 2.53, 95% confidence interval = 0.86-8.02; P = 0.088). The mean satisfaction rate was 9.3/10, and no negative occurrences were reported. Conclusion. A single session of dog-assisted therapy can provide immediate improvement in the perception of pain and distress for patients with chronic cancer pain in an outpatient setting, with high satisfaction rates and no negative occurrences. This nonrandomized pilot study points toward the clinical relevance of implementing cynotherapy at a cancer pain clinic and developing a larger scale, more directed study.
C1 [Carvalho, Filipe Silva] EPE, Unidade Psiquiatria, Inst Portugues Oncol Lisboa Francisco Gentil, Rua Prof Lima Basto, P-1099023 Lisbon, Portugal.
   [Carvalho, Susana] EPE, Clin Dor, Inst Portugues Oncol Lisboa Francisco Gentil, Lisbon, Portugal.
   [Conde, Rita] EPE, Serv Oncol Med, Inst Portugues Oncol Lisboa Francisco Gentil, Lisbon, Portugal.
   [Esteves, Susana] EPE, Unidade Investigaqeo Clin, Inst Portugues Oncol Lisboa Francisco Gentil, Lisbon, Portugal.
RP Carvalho, FS (corresponding author), EPE, Unidade Psiquiatria, Inst Portugues Oncol Lisboa Francisco Gentil, Rua Prof Lima Basto, P-1099023 Lisbon, Portugal.
EM fcarvalho@ipolisboa.min-saude.pt
RI Esteves, Susana/GON-7824-2022
OI Esteves, Susana/0000-0001-8779-8665; Saúde Conde,
   Rita/0000-0002-4376-6896
FU Liga Portuguesa Contra o Cancro
FX Funding was entirely granted by Liga Portuguesa Contra o Cancro. The
   costs of the project consisted of the honoraria of the animalassisted
   therapists, 2-3 hours/week for 20 weeks.
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NR 44
TC 6
Z9 7
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD DEC
PY 2021
VL 22
IS 12
BP 3051
EP 3061
DI 10.1093/pm/pnab118
EA MAR 2021
PG 11
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA YI1JL
UT WOS:000743612400032
PM 33760046
DA 2026-01-16
ER

PT J
AU Liu, X
   Li, SQ
   Wang, BG
   An, LX
   Ren, XJ
   Wu, HF
AF Liu, Xing
   Li, Shuqin
   Wang, Baoguo
   An, Lixin
   Ren, Xiujun
   Wu, Haifeng
TI Intraoperative and postoperative anaesthetic and analgesic effect of
   multipoint transcutaneous electrical acupuncture stimulation combined
   with sufentanil anaesthesia in patients undergoing supratentorial
   craniotomy
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID ACUPOINT STIMULATION; CONTROLLED-TRIAL; CLINICAL-TRIAL;
   ELECTROACUPUNCTURE; PAIN; RECOVERY; NAUSEA; PHARMACOKINETICS; SURGERY
AB Objectives To investigate the anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation (TEAS) during supratentorial tumour resection for postoperative recovery and side effects.
   Methods In a blinded clinical trial, 92 patients scheduled for supratentorial craniotomy under general anaesthesia were randomly allocated into either a multipoint TEAS (n=46) or a sham TEAS group (n=46). All patients received total intravenous anaesthesia (TIVA) with propofol and sufentanil. The target concentration of sufentanil was adjusted and recorded according to mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS). Patients in the TEAS group received TEAS 30 min before anaesthesia induction and this was maintained throughout the operation at four pairs of acupuncture points. Postoperative pain, recovery and side effects were evaluated.
   Results Eighty-eight patients completed the study. Continuous monitoring of MAP, HR and BIS showed stable values with no significant differences between the two groups (p>0.05). Sufentanil target plasma concentration in TEAS patients was significantly lower at some time points during supratentorial craniotomy, and total sufentanil consumption was significantly higher in the sham group (p<0.05). Postoperative recovery and pain were significantly improved by TEAS (p<0.001), without the postoperative side effects.
   Conclusions Multipoint TEAS at both proximal and distal points combined with TIVA can significantly decrease intraoperative sufentanil requirements, increase pain relief on postoperative day 1 and improve postoperative recovery of patients during supratentorial tumour resection, with no significant increase of side effects. These findings suggest that multipoint TEAS may be clinically effective as an adjunct to analgesia in intraoperative anaesthesia and postoperative pain treatment and may speed recovery.
C1 [Liu, Xing; Li, Shuqin; An, Lixin] Capital Med Univ, Tian Tan Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Wang, Baoguo] Capital Med Univ, Sanbo Brain Hosp, Dept Anesthesiol, Beijing, Peoples R China.
   [Ren, Xiujun] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Wu, Haifeng] China Rehabil Res Ctr, Teaching Affairs Dept, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Beijing
   University of Chinese Medicine
RP Wang, BG (corresponding author), Dept Anesthesiol, Beijing 100093, Peoples R China.
EM baoguowang766@163.com
FU National key basic research development programme (973 programme) of
   China [2013CB531901]
FX National key basic research development programme (973 programme, No
   2013CB531901) of China.
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NR 27
TC 45
Z9 55
U1 0
U2 33
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD AUG
PY 2015
VL 33
IS 4
BP 270
EP 276
DI 10.1136/acupmed-2014-010749
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CQ1UW
UT WOS:000360386600003
PM 25926298
DA 2026-01-16
ER

PT J
AU Chen, L
   Lin, CC
   Huang, TW
   Kuan, YC
   Huang, YH
   Chen, HC
   Kao, CY
   Su, CM
   Tam, KW
AF Chen, Lawrence
   Lin, Chao-Chun
   Huang, Tsai-Wei
   Kuan, Yi-Chun
   Huang, Yao-Hsien
   Chen, Hung-Chou
   Kao, Chun-Yu
   Su, Chih-Ming
   Tam, Ka-Wai
TI Effect of acupuncture on arornatase inhibitor-induced arthralgia in
   patients with breast cancer: A meta-analysis of randomized controlled
   trials
SO BREAST
LA English
DT Article
DE Acupuncture; Aromatase inhibitor-induced arthralgia; Meta-analysis;
   Breast cancer
ID JOINT SYMPTOMS; AROMATASE; WOMEN; ELECTROACUPUNCTURE
AB Purpose: Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA.
   Methods: The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were searched for studies published before February 2017. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate the pooled effect size by using a random effect model. Pain was assessed using the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3-4, 6-8, and 12 weeks. Secondary outcomes included disability level, upper extremity function, physical performance, and quality of life.
   Results: Five trials involving 181 patients were reviewed. Significant pain reduction was observed after 6 8 weeks of acupuncture treatment. Patients receiving acupuncture showed a significant decrease in the BPI worst pain score (weighted mean difference [WMD]: -3.81, 95% confidence interval [CI]: -5.15 to -2.47) and the WOMAC pain score (WMD: -130.77, 95% CI: -230.31 to -31.22) after 6-8 weeks of treatment. One of the 4 trials reported 18 minor adverse events in 8 patients during 398 intervention episodes.
   Conclusion: Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Chen, Lawrence; Lin, Chao-Chun; Chen, Hung-Chou; Tam, Ka-Wai] Taipei Med Univ, Shuang Ho Hosp, Ctr Evidence Based Hlth Care, 291 Zhongzheng Rd, New Taipei 23561, Taiwan.
   [Huang, Tsai-Wei] HungKuang Univ, Dept Nursing, Coll Med & Nursing, Taichung, Taiwan.
   [Kuan, Yi-Chun; Huang, Yao-Hsien] Taipei Med Univ, Shuang Ho Hosp, Dept Neurol, New Taipei, Taiwan.
   [Kuan, Yi-Chun] Taipei Med Univ, Sch Med, Dept Neurol, Taipei, Taiwan.
   [Chen, Hung-Chou] Taipei Med Univ, Shuang Ho Hosp, Dept Phys Med & Rehabil, New Taipei, Taiwan.
   [Kao, Chun-Yu] Taipei Med Univ, Dept Surg, Shuang Ho Hosp, Div Pediat Surg, Taipei, Taiwan.
   [Su, Chih-Ming; Tam, Ka-Wai] Taipei Med Univ, Shuang Ho Hosp, Div Gen Surg, Dept Surg, New Taipei, Taiwan.
   [Su, Chih-Ming; Tam, Ka-Wai] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei, Taiwan.
   [Tam, Ka-Wai] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
C3 Taipei Medical University; Shuang Ho Hospital; Hungkuang University;
   Taipei Medical University; Shuang Ho Hospital; Taipei Medical
   University; Taipei Medical University; Shuang Ho Hospital; Taipei
   Medical University; Shuang Ho Hospital; Taipei Medical University;
   Shuang Ho Hospital; Taipei Medical University; Taipei Medical University
RP Tam, KW (corresponding author), Taipei Med Univ, Shuang Ho Hosp, Ctr Evidence Based Hlth Care, 291 Zhongzheng Rd, New Taipei 23561, Taiwan.
EM kelvintam@h.tmu.edu.tw
RI Su, ChihMing/KOD-8182-2024; Huang, Tsai-Wei/A-1690-2019
OI Chen, Hung-Chou/0000-0001-8510-7437; Huang, Tsai-Wei/0000-0002-6722-1153
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NR 24
TC 48
Z9 56
U1 0
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0960-9776
EI 1532-3080
J9 BREAST
JI Breast
PD JUN
PY 2017
VL 33
BP 132
EP 138
DI 10.1016/j.breast.2017.03.015
PG 7
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA EW0WB
UT WOS:000402210800020
PM 28384564
OA hybrid
DA 2026-01-16
ER

PT J
AU Bao, T
   Baser, R
   Chen, C
   Weitzman, M
   Zhang, YL
   Seluzicki, C
   Li, QS
   Piulson, L
   Zhi, WI
AF Bao, Ting
   Baser, Raymond
   Chen, Connie
   Weitzman, Matthew
   Zhang, Yi Lily
   Seluzicki, Christina
   Li, Qing Susan
   Piulson, Lauren
   Zhi, W. Iris
TI Health-Related Quality of Life in Cancer Survivors with
   Chemotherapy-Induced Peripheral Neuropathy: A Randomized Clinical Trial
SO ONCOLOGIST
LA English
DT Article
DE Acupuncture; Neuropathy; Quality of life; Cancer; Anxiety; Insomnia
ID INSOMNIA SEVERITY INDEX; ACUPUNCTURE; SYMPTOMS; PREVALENCE; PAIN;
   VALIDATION; ANXIETY; RISK
AB Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating adverse effect of neurotoxic chemotherapy that significantly worsens the quality of life of cancer survivors. Materials and Methods Survivors of solid tumors with persistent moderate-to-severe CIPN defined as numbness, tingling, or pain rated >= 4 on an 11-point numeric rating scale (NRS) were randomized in a 1:1:1 ratio to 8 weeks of real acupuncture (RA) versus sham acupuncture (SA) versus usual care (UC). We previously reported the primary endpoint (NRS); here we report the following health-related quality of life endpoints: Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), and Brief Fatigue Inventory (BFI). For each endpoint, the mean changes from baseline and 95% confidence intervals were estimated within each arm and compared between arms using linear mixed models. Results We enrolled 75 survivors of solid tumors with moderate-to-severe CIPN into the study. Compared with baseline, at week 8, FACT/GOG-Ntx, HADS anxiety, and ISI scores significantly improved in RA and SA, but not in UC. Compared with UC, at week 8, FACT/GOG-Ntx scores significantly increased in RA and SA arms indicating improved CIPN-related symptoms and quality of life (p = .001 and p = .01). There was no statistically significant difference between RA and SA. There was no difference in HADS depression or BFI among RA, SA, and UC at weeks 8 and 12. Conclusion Acupuncture may improve CIPN-related symptoms and quality of life in cancer survivors with persistent CIPN. Further large sample size studies are needed to delineate placebo effects. Implications for Practice The authors conducted a randomized sham acupuncture- and usual care-controlled clinical trial to evaluate the impact of acupuncture on health-related quality of life outcomes in patients with solid tumors with chemotherapy-induced peripheral neuropathy (CIPN). Statistically significant improvements in quality of life, anxiety, insomnia, and fatigue were achieved with 8 weeks of real acupuncture when compared with baseline, without statistically significant differences between real and sham acupuncture. These findings suggest that acupuncture may be effective for improving CIPN-related symptoms and quality of life and reducing anxiety and insomnia in cancer survivors with persistent CIPN, with further study needed to delineate placebo effects.
C1 [Bao, Ting; Weitzman, Matthew; Zhang, Yi Lily; Seluzicki, Christina; Li, Qing Susan; Piulson, Lauren] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 1275 York Ave, New York, NY 10021 USA.
   [Baser, Raymond] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
   [Chen, Connie] NYU, Winthrop Hosp, Dept Med, Mineola, NY USA.
   [Zhi, W. Iris] Mem Sloan Kettering Canc Ctr, Dept Med, Breast Med Serv, Commack, NY USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; New York University; Memorial Sloan Kettering Cancer Center
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Bendheim Integrat Med Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM baot@mskcc.org
RI ; Weitzman, Matthew/ITT-9808-2023
OI Bao, Ting/0000-0003-4437-2597; Seluzicki, Christina/0000-0002-8553-6810;
   Zhi, Iris/0000-0003-4263-7272; Weitzman, Matthew/0000-0003-3439-0353
FU National Institutes of Health/National Cancer Institute Cancer Center
   grant [P30 CA008748]; Translational and Integrative Medicine Research
   Fund at Memorial Sloan Kettering Cancer Center; Frueauff Foundation;
   National Cancer Institute [R37CA248563, R01CA251470, R01CA240417];
   National Cancer Institute [R01CA251470, R01CA240417, R37CA248563,
   P30CA008748] Funding Source: NIH RePORTER
FX The authors thank Patricia Chen for her assistance conducting this
   study. The authors also thank all the cancer survivors in the study for
   their participation. This work was supported in part by a National
   Institutes of Health/National Cancer Institute Cancer Center grant
   (grant number P30 CA008748), the Translational and Integrative Medicine
   Research Fund at Memorial Sloan Kettering Cancer Center, and the
   Frueauff Foundation. The funding sources were not involved in the study
   design; collection, analysis and interpretation of data; writing of the
   report; or decision to submit the article for publication. Ting Bao is
   supported by the National Cancer Institute (grant numbers R37CA248563,
   R01CA251470, and R01CA240417).
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NR 32
TC 41
Z9 43
U1 4
U2 35
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD NOV
PY 2021
VL 26
IS 11
BP E2070
EP E2078
DI 10.1002/onco.13933
EA AUG 2021
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA WS3HH
UT WOS:000688482800001
PM 34390283
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Chen, XJ
   Mi, WL
   Gao, TC
   Ding, FF
   Wang, W
AF Chen, Xuejiao
   Mi, Wenli
   Gao, Tianchi
   Ding, Fengfei
   Wang, Wei
TI Astrocytes in the rostral ventromedial medulla mediate the analgesic
   effect of electroacupuncture in a rodent model of chemotherapy-induced
   peripheral neuropathic pain
SO PAIN
LA English
DT Article
DE Paclitaxel; Electroacupuncture; Neuropathic pain; Rostral ventromedial
   medulla; Astrocyte
ID MECHANICAL ALLODYNIA; ACTIVATION; INHIBITION; PACLITAXEL; RECEPTOR;
   RATS; ACUPUNCTURE; STIMULATION; INVOLVEMENT; CONTRIBUTE
AB Chemotherapy-induced peripheral neuropathic pain aggravates cancer survivors' life burden. Electroacupuncture (EA) has exhibited promising analgesic effects on neuropathic pain in previous studies. We investigated whether EA was effective in a paclitaxel-induced neuropathic pain mouse model. We further explored the functional role of astrocytes in the rostral ventromedial medulla (RVM), a well-established pain modulation center, in the process of neuropathic pain as well as the analgesic effect of EA. We found that paclitaxel induced mechanical allodynia, astrocytic calcium signaling, and neuronal activation in the RVM and spinal cord, which could be suppressed by EA treatment. Electroacupuncture effectively alleviated paclitaxel-induced mechanical allodynia, and the effect was attenuated by the chemogenetic activation of astrocytes in the RVM. In addition, inhibiting astrocytic calcium activity by using either IP3R2 knockout (IP3R2 KO) mice or microinjection of AAV-mediated hPMCA2 w/b into the RVM to reduce non-IP3R2-dependent Ca2+ signaling in astrocytes exhibited an analgesic effect on neuropathic pain, which mimicked the EA effect. The current study revealed the pivotal role of the RVM astrocytes in mediating the analgesic effects of EA on chemotherapy-induced peripheral neuropathic pain.
C1 [Chen, Xuejiao; Wang, Wei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, 1905 Jiefang Rd, Wuhan 430010, Hubei, Peoples R China.
   [Mi, Wenli; Gao, Tianchi] Fudan Univ, Inst Integrat Med, Sch Basic Med Sci, Dept Integrat Med & Neurobiol,Shanghai Key Lab Acu, Shanghai, Peoples R China.
   [Mi, Wenli; Gao, Tianchi] Fudan Univ, Inst Brain Sci, Shanghai Med Coll, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China.
   [Ding, Fengfei] Fudan Univ, Inst Brain Sci, Shanghai Med Coll, Frontiers Ctr Brain Sci,Sch Basic Med Sci,Dept Pha, Shanghai, Peoples R China.
   [Ding, Fengfei] Fudan Univ, Inst Brain Sci, Shanghai Med Coll, Frontiers Ctr Brain Sci,Minist Educ, Shanghai, Peoples R China.
   [Wang, Wei] Huazhong Univ Sci & Technol, Hubei Key Lab Neural Injury & Funct Reconstruct, Wuhan, Peoples R China.
   [Wang, Wei] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Minist Educ,Key Lab Neurol Dis Chinese, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Fudan University; Fudan
   University; Fudan University; Fudan University; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Wang, W (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, 1905 Jiefang Rd, Wuhan 430010, Hubei, Peoples R China.
EM xuejiaochen_2020@163.com; wenlimi@fudan.edu.cn;
   21211010084@m.fudan.edu.cn; wwang@vip.126.com
RI ; Mi, Wenli/P-5541-2019
OI Ding, Fengfei/0000-0001-5589-3668; 
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NR 63
TC 8
Z9 9
U1 10
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD APR
PY 2025
VL 166
IS 4
BP 916
EP 926
DI 10.1097/j.pain.0000000000003433
PG 11
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 0GY4Z
UT WOS:001447121700010
PM 39432736
DA 2026-01-16
ER

PT J
AU Garcia, MK
   McQuade, J
   Haddad, R
   Patel, S
   Lee, R
   Yang, PY
   Palmer, JL
   Cohen, L
AF Garcia, M. Kay
   McQuade, Jennifer
   Haddad, Robin
   Patel, Sonya
   Lee, Richard
   Yang, Peiying
   Palmer, J. Lynn
   Cohen, Lorenzo
TI Systematic Review of Acupuncture in Cancer Care: A Synthesis of the
   Evidence
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Review
ID CHEMOTHERAPY-INDUCED NAUSEA; RANDOMIZED CONTROLLED-TRIAL; PROLONGED
   POSTOPERATIVE ILEUS; BREAST-CANCER; PLACEBO-ACUPUNCTURE; VASOMOTOR
   SYMPTOMS; ELECTROACUPUNCTURE; MANAGEMENT; PAIN; WOMEN
AB Purpose
   Many cancer centers offer acupuncture services. To date, a comprehensive systematic review of acupuncture in cancer care has not been conducted. The purpose of this review was to evaluate the efficacy of acupuncture for symptom management in patients with cancer.
   Methods
   Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 for prospective randomized clinical trials (RCT) evaluating acupuncture for symptom management in cancer care. Only studies involving needle insertion into acupuncture points were included. No language limitations were applied. Studies were assessed for risk of bias (ROB) according to Cochrane criteria. Outcomes by symptom were designated as positive, negative, or unclear.
   Results
   A total of 2,151 publications were screened. Of those, 41 RCTs involving eight symptoms (pain, nausea, hot flashes, fatigue, radiation-induced xerostomia, prolonged postoperative ileus, anxiety/mood disorders, and sleep disturbance) met all inclusion criteria. One positive trial of acupuncture for chemotherapy-induced nausea and vomiting had low ROB. Of the remaining studies, eight had unclear ROB (four positive, three negative, and one with unclear outcomes). Thirty-three studies had high ROB (19 positive, 11 negative, and three with both positive and negative outcomes depending on the symptom).
   Conclusion
   Acupuncture is an appropriate adjunctive treatment for chemotherapy-induced nausea/vomiting, but additional studies are needed. For other symptoms, efficacy remains undetermined owing to high ROB among studies. Future research should focus on standardizing comparison groups and treatment methods, be at least single-blinded, assess biologic mechanisms, have adequate statistical power, and involve multiple acupuncturists. J Clin Oncol 31:952-960. (C) 2013 by American Society of Clinical Oncology
C1 [Garcia, M. Kay; Haddad, Robin; Lee, Richard; Yang, Peiying; Palmer, J. Lynn; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Garcia, M. Kay; Patel, Sonya] MHlth Multidisciplinary Pain Management Program, Houston, TX USA.
   [McQuade, Jennifer] Hosp Univ Penn, Philadelphia, PA 19104 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Pennsylvania
RP Cohen, L (corresponding author), Univ Texas MD Anderson Canc Ctr, Integrat Med Program, 1515 Holcombe Blvd,Unit 0462, Houston, TX 77030 USA.
EM lcohen@mdanderson.org
RI Lee, Richard/AAS-1416-2021
OI Lee, Richard/0000-0001-9916-6155
FU National Cancer Institute [CA121503, CA016672]; University of Texas MD
   Anderson Cancer Center; National Cancer Institute [P30CA016672] Funding
   Source: NIH RePORTER
FX Supported in part by National Cancer Institute Grants No. CA121503 and
   CA016672 and by The University of Texas MD Anderson Cancer Center.
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NR 67
TC 229
Z9 266
U1 2
U2 117
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAR 1
PY 2013
VL 31
IS 7
BP 952
EP 960
DI 10.1200/JCO.2012.43.5818
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 097AU
UT WOS:000315447200026
PM 23341529
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Li, K
   Giustini, D
   Seely, D
AF Li, K.
   Giustini, D.
   Seely, D.
TI A systematic review of acupuncture for chemotherapy-induced peripheral
   neuropathy
SO CURRENT ONCOLOGY
LA English
DT Review
DE Acupuncture; systematic reviews; chemotherapy-induced peripheral
   neuropathy; CIPN; integrative oncology
ID QUALITY-OF-LIFE; ELECTROACUPUNCTURE; PAIN; XEROSTOMIA; MANAGEMENT
AB Objectives In cancer patients, chemotherapy-induced peripheral neuropathy (CIPN) is a common complication, characterized by pain, loss of sensation, and numbness. Medical treatment for peripheral neuropathies has been shown to be ineffective for CIPN. Acupuncture has been shown to be safe and effective in treating cancer-related symptoms and other peripheral neuropathies. For the present review, we aimed to evaluate the efficacy of acupuncture for the treatment of CIPN.
   Design Comprehensive searches for relevant studies were conducted in Ovid EMBASE, the Web of Science, Ovid MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO Information Services, Ipswich, MA, U.S.A.), and the ClinicalTrials. gov Web site. References from previous systematic reviews were also searched. Additional trials were found in the reference lists of relevant papers and in searches of Google Scholar and acupuncture-specific Web sites. Included studies were randomized controlled trials (RCTS) of any type of acupuncture used to treat patients with CIPN.
   Results Three clinical trials (203 participants) were included. Two studies found acupuncture to be effective in alleviating CIPN pain and improving quality of life. One study found no benefit in improving neuropathic pain, symptoms, or quality of life. Study quality was variable and included a moderate overall risk of bias.
   Conclusions The evidence is insufficient to recommend acupuncture for the treatment or prevention of CIPN. Further research is needed to evaluate the effects of acupuncture in the treatment of CIPN. Given that acupuncture is considered safe and might provide relief for patients, it can be considered at the clinician's discretion.
C1 [Li, K.] Univ British Columbia, Fac Med, 317-2194 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
   [Giustini, D.] Univ British Columbia, Biomed Branch Lib, Vancouver, BC, Canada.
   [Seely, D.] Ottawa Integrat Canc Ctr, Ottawa, ON, Canada.
C3 University of British Columbia; University of British Columbia
RP Li, K (corresponding author), Univ British Columbia, Fac Med, 317-2194 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
EM kevin94li@alumni.ubc.ca
RI Giustini, Dean/A-3714-2014; Seely, Dugald/IAR-5574-2023
OI Giustini, Dean/0000-0002-6197-8788; 
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
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NR 37
TC 43
Z9 54
U1 0
U2 26
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 1198-0052
J9 CURR ONCOL
JI Curr. Oncol.
PD APR
PY 2019
VL 26
IS 2
BP E147
EP E154
DI 10.3747/co.26.4261
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA HV7OU
UT WOS:000466171200004
PM 31043820
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kaul, I
   Busby, K
   Yeh, AM
AF Kaul, Ila
   Busby, Ken
   Yeh, Ann Ming
TI Integrative medicine consults in a pediatric hospital: A case series
SO EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
LA English
DT Article
DE Case series; Acupressure; Massage; Aromatherapy; Hypnosis
ID ACUPUNCTURE; ONCOLOGY; CHILDREN; THERAPY; CANCER; PAIN
AB Pediatric integrative medicine (PIM) is a holistic approach to health care that combines conventional pediatric treatments with evidence-based complementary therapies to support the physical, emotional, and spiritual wellbeing of children and their caretakers. It encompasses a wide range of modalities, including acupuncture, massage therapy, mindfulness, guided imagery, and nutritional counseling, tailored to meet the developmental and medical needs of pediatric patients. The goal of PIM is to support treatment by integrating family values, lifestyle, and stress management into care plans through different therapies. In this report, the existing literature of pediatric inpatient integrative medicine interventions is reviewed, and three patient case studies illustrate the impact of a pilot integrative medicine consultation service in a tertiary care children's hospital. These cases will reflect integrative medicine modalities to provide non-pharmacologic symptom management through approaches such as massage, acupressure, clinical hypnosis, guided imagery, and breathing techniques.
C1 [Kaul, Ila] Dartmouth Coll, Geisel Sch Med, Lebanon, NH 03755 USA.
   [Busby, Ken] Emory Univ, Sch Med, Dept Pediat, Pediat Hematol & Oncol, Atlanta, GA USA.
   [Yeh, Ann Ming] Stanford Univ, Sch Med, Dept Pediat, Pediat Gastroenterol Hepatol & Nutr, Palo Alto, CA USA.
C3 Dartmouth College; Emory University; Stanford University
RP Kaul, I (corresponding author), Dartmouth Coll, Geisel Sch Med, Lebanon, NH 03755 USA.
EM ila.k.kaul.med@dartmouth.edu
CR Bryl K, 2023, CURR ONCOL, V30, P6497, DOI 10.3390/curroncol30070477
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   Torres-Luna R, 2025, AN PEDIATR, V102, DOI [10.1016/j.anpede.2025.503831, 10.1016/j.anpede.2025.503831, 10.1016/j.anpedi.2025.503831]
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NR 12
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-8307
EI 1878-7541
J9 EXPLORE-NY
JI Explore-J Sci. Heal.
PD NOV-DEC
PY 2025
VL 21
IS 6
AR 103259
DI 10.1016/j.explore.2025.103259
EA SEP 2025
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7KR1I
UT WOS:001573298100001
PM 40945035
DA 2026-01-16
ER

PT J
AU Yu, ML
   Wei, RD
   Zhang, T
   Wang, JM
   Cheng, Y
   Qin, FF
   Fu, SP
   Lu, ZG
   Lu, SF
AF Yu, Mei-ling
   Wei, Rui-de
   Zhang, Tao
   Wang, Jun-meng
   Cheng, Yu
   Qin, Fen-fen
   Fu, Shu-ping
   Lu, Zhi-gang
   Lu, Sheng-feng
TI Electroacupuncture Relieves Pain and Attenuates Inflammation Progression
   Through Inducing IL-10 Production in CFA-Induced Mice
SO INFLAMMATION
LA English
DT Article
DE electroacupuncture treatment; analgesia; IL-10; regulatory T cells;
   pro-inflammatory cytokines; CFA-induced mice
ID TUMOR-NECROSIS-FACTOR; NLRP3 INFLAMMASOME; NEUROPATHIC PAIN; MACROPHAGE;
   ACUPUNCTURE; ACTIVATION; THERAPY; INJURY; CELLS; INTERLEUKIN-1-BETA
AB The therapeutic effect of electroacupuncture (EA) on inflammatory pain has been well recognized clinically, but the mechanism is unclear. Interleukin-10 (IL-10), which is produced by regulatory T (Treg) cell, is a key anti-inflammatory cytokine for relieving inflammatory pain. Therefore, the aim of this study is to investigate whether EA could inhibit CFA-induced pain and attenuate inflammation progression by regulating the activation of immunocyte and inducing the expression of IL-10. In this study, mice were treated with EA (2/100 Hz, 2 mA) for five consecutive days after 1 day of CFA injection. The behavioral tests were measured and analyzed after the daily EA treatment; then, hind paw, spinal cord, and spleen tissues were prepared for assessment. The results showed that EA treatment significantly increased the mechanical threshold and thermal latency after CFA injection and boosted the expression of IL-10 in paw and spinal cord tissues. EA treatment promoted Treg cells; suppressed macrophage and neutrophils cells; reduced the expression of IL-1 beta, NLRP3, and TNF-alpha; and ultimately relieved inflammatory pain. The findings suggested that the analgesic and anti-inflammatory effect of EA treatment could be partially associated with suppression of pro-inflammatory cytokines mediated by induction of IL-10.
C1 [Yu, Mei-ling; Lu, Zhi-gang] Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing, Peoples R China.
   [Yu, Mei-ling; Zhang, Tao; Cheng, Yu; Qin, Fen-fen; Fu, Shu-ping; Lu, Zhi-gang; Lu, Sheng-feng] Nanjing Univ Chinese Med, Minist Educ, Key Lab Acupuncture & Med Res, Nanjing, Peoples R China.
   [Wei, Rui-de] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing, Peoples R China.
   [Wang, Jun-meng] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Chengdu University of
   Traditional Chinese Medicine
RP Lu, ZG; Lu, SF (corresponding author), Nanjing Univ Chinese Med, Minist Educ, Key Lab Acupuncture & Med Res, Nanjing, Peoples R China.
EM Luzg@njucm.edu.cn; lushengfeng@njucm.edu.cn
RI ; Qin, Fenfen/GRX-4320-2022
OI Fu, Shuping/0000-0002-4047-9330; Wang, Jun-meng/0000-0003-3771-4026; lu,
   Shengfeng/0000-0001-5600-0999; Qin, Fenfen/0000-0003-4450-4721
FU National Natural Science Foundation of China [81774210, 81574062];
   "SixMajor Talent Summit" of Jiangsu Province [YY-033]; Jiangsu Province
   "333 High-level Talents Cultivating Project" (2016); "Qing Lan Project"
   of Jiangsu Province; Nursing Priority Academic Program Development of
   Jiangsu Higher Education Institutions [2019YSHL046]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81774210, 81574062), "SixMajor Talent Summit" of Jiangsu
   Province (YY-033), Jiangsu Province "333 High-level Talents Cultivating
   Project" (2016), "Qing Lan Project" of Jiangsu Province and A Project
   Funded by the Nursing Priority Academic Program Development of Jiangsu
   Higher Education Institutions (2019YSHL046). The funders have no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 67
TC 43
Z9 55
U1 4
U2 30
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2020
VL 43
IS 4
BP 1233
EP 1245
DI 10.1007/s10753-020-01203-2
EA MAR 2020
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA MO5ES
UT WOS:000520907000001
PM 32198725
DA 2026-01-16
ER

PT J
AU Zomers, PJW
   Groeneweg, G
   Baart, S
   Huygen, FJP
AF Zomers, Paul J. W.
   Groeneweg, George
   Baart, Sara
   Huygen, Frank J. P.
TI Percutaneous Cervical Cordotomy for the Treatment of Cancer Pain: A
   Prospective Case Series of 52 Patients with a Long-Term Follow-Up
SO PAIN PRACTICE
LA English
DT Article
DE radiofrequency ablation; percutaneous cervical cordotomy; oncological
   pain
ID RELIABILITY; EFFICACY; SAFETY; SCALE
AB Aim The aim of this study is to describe the effects of percutaneous cervical cordotomy (PCC) on pain, opioid consumption, adverse events, and satisfaction in palliative care patients with cancer pain after PCC until end of life.
   Methods This is a prospective observational case series of 58 PCCs in 52 consecutive patients. Indication for PCC was unilateral cancer pain with a maximum numeric rating scale (NRS) of pain above 5 despite maximal conservative treatment. The PCC was fluoroscopy guided. A radiofrequency lesion was made at 95 degrees C for 20 seconds. The pain location and pain scores, analgesic medication, the cranial and caudal borders of dermatomes hypoesthetic for pin pricks, dysesthesia, urinary retention, Horner's syndrome, muscle strength, Karnofsky performance scale (KPS) score, patient satisfaction, hospital anxiety and distress score (HADS), and RAND 36 score were evaluated at 1 day; 1 and 6 weeks; and 3, 6, 9, 12 18, and 24 months after PCC, or until death if death occurred during the follow-up period.
   Results Pain relief after PCC was intense (change in median maximum NRS from 9 to 0) and persistent. Median opioid use per day was 240 mg (145 to 565 mg) before PCC and 55 mg (0 to 120 mg) after PCC. The upper and lower borders of dermatomes hypoesthetic for pin pricks were stable over time. The most common side effects were short-term (< 1 week) neck pain (28%), dysesthesia (40%), and mild loss of muscle strength (11%). Approximately 83% of the patients were satisfied or very satisfied with the results of PCC 1 week after the procedure, and this percentage remained high in the long term. There was no significant change in the KPS score, HADS, and RAND 36 score.
   Conclusion Percutaneous cervical cordotomy is an effective treatment for unilateral cancer pain. The reduction in pain, reduction in opioid consumption, and hypoesthetic area remain stable until death.
C1 [Zomers, Paul J. W.] Bravis Hosp, Pain Dept, Boerhaavelaan 25, NL-4708 AE Roosendaal, Netherlands.
   [Groeneweg, George; Baart, Sara; Huygen, Frank J. P.] Erasmus MC, Ctr Pain Med, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Zomers, PJW (corresponding author), Bravis Hosp, Pain Dept, Boerhaavelaan 25, NL-4708 AE Roosendaal, Netherlands.
EM paulzomers@ziggo.nl
RI ; Groeneweg, Johannes George/A-9956-2015
OI Zomers, Paul/0000-0001-8647-7907; Huygen, Frank JPM/0000-0002-2852-4880;
   Groeneweg, Johannes George/0000-0001-6072-0446
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NR 52
TC 5
Z9 5
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1530-7085
EI 1533-2500
J9 PAIN PRACT
JI Pain Pract.
PD JUN
PY 2021
VL 21
IS 5
BP 557
EP 567
DI 10.1111/papr.12991
EA JAN 2021
PG 11
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA SN8JM
UT WOS:000609940800001
PM 33350042
DA 2026-01-16
ER

PT J
AU Lyu, C
   Xiao, HY
   Yin, XW
   Li, ZH
   Han, C
   Xu, RR
AF Lyu, Chunyi
   Xiao, Hongyan
   Yin, Xuewei
   Li, Zonghong
   Han, Chen
   Xu, Ruirong
TI Acupuncture in Multiple Myeloma Peripheral Neuropathy
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE multiple myeloma peripheral neuropathy; acupuncture; pain; systematic
   review
ID PAIN; BORTEZOMIB; VALIDATION; MANAGEMENT
AB Background: Peripheral neuropathy (PN) is a prevalent complication of multiple myeloma (MM), due to the disease itself or its treatment. Despite extensive research, the optimal treatment for multiple myeloma peripheral neuropathy (MMPN) remains unclear. Clinical practice has shown the potential efficacy of acupuncture in managing MMPN. This study aimed to conduct a comprehensive analysis of the literature to assess the effectiveness and safety of acupuncture as a treatment for MMPN. Methods: The PubMed, Web of Science, MEDLINE, Cochrane Library, and Embase databases were comprehensively searched from inception to November 1, 2023 to identify relevant studies pertaining to the use of acupuncture to treat MMPN. Results: A total of five studies, encompassing 97 patients diagnosed with drug-related PN, were ultimately included in this analysis. The literature lacks any reports pertaining to the utilization of acupuncture for disease-related PN. ST36, LI4, SP6, and EX-LE-10 were found to be the most frequently chosen acupoints. Following acupuncture treatment, there was a consistent reduction in scores on the Visual Analogue Scale (VAS), Neuropathic Pain Scale (NPS), Brief Pain Inventory-Short Form (BPI-SF), and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) among MMPN patients. The results of Nerve Conduction Velocity (NCV) tests yielded conflicting results. No severe adverse effects were reported. Conclusion: The use of acupuncture for disease-related PN has not been studied to date. Acupuncture is safe for drug-related PN and is helpful for relieving pain. But uncertainty exists regarding the efficacy of this approach because there is substantial heterogeneity with respect to acupuncture treatment regimens, and more high-quality studies on this topic are warranted.
C1 [Lyu, Chunyi; Xiao, Hongyan; Li, Zonghong; Han, Chen] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250014, Peoples R China.
   [Xiao, Hongyan] Shandong Univ Tradit Chinese Med, Affiliated Eye Hosp, Jinan 250002, Peoples R China.
   [Xu, Ruirong] Shandong Univ Tradit Chinese Med, Key Lab Integrated Tradit Chinese & Western Med He, Hlth Commiss Shandong Prov, Jinan 250014, Peoples R China.
   [Xu, Ruirong] Shandong Univ Tradit Chinese Med, Inst Hematol, Jinan 250014, Peoples R China.
   [Xu, Ruirong] Shandong Univ Tradit Chinese Med, Dept Hematol, Affiliated Hosp, Jinan 250014, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong University of Traditional Chinese Medicine;
   Shandong University of Traditional Chinese Medicine
RP Xu, RR (corresponding author), Shandong Univ Tradit Chinese Med, Key Lab Integrated Tradit Chinese & Western Med He, Hlth Commiss Shandong Prov, Jinan 250014, Peoples R China.; Xu, RR (corresponding author), Shandong Univ Tradit Chinese Med, Inst Hematol, Jinan 250014, Peoples R China.; Xu, RR (corresponding author), Shandong Univ Tradit Chinese Med, Dept Hematol, Affiliated Hosp, Jinan 250014, Peoples R China.
EM shandongxuruirong@163.com
OI Lyu, Chunyi/0000-0003-0184-9930; Xu, Ruirong/0000-0002-9871-1542
FU Natural Science Foundation of Shandong Province [ZR2020KH023]
FX Funding This study was supported by the Natural Science Foundation of
   Shandong Province (grant number: ZR2020KH023) .
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NR 40
TC 1
Z9 3
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2024
VL 17
BP 1571
EP 1581
DI 10.2147/JPR.S448634
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA QF0D0
UT WOS:001219336600001
PM 38699068
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, WD
   Posner, MR
   Wayne, P
   Rosenthal, DS
   Haddad, RI
AF Lu, Weidong
   Posner, Marshall R.
   Wayne, Peter
   Rosenthal, David S.
   Haddad, Robert I.
TI Acupuncture for Dysphagia After Chemoradiation Therapy in Head and Neck
   Cancer: A Case Series Report
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; chemoradiation therapy; radiation therapy; head and neck
   cancer; dysphagia; percutaneous endoscopic gastrostomy (PEG) tube
ID LOCALLY ADVANCED HEAD; QUALITY-OF-LIFE; RADIATION-INDUCED XEROSTOMIA;
   ORGAN PRESERVATION; INTRAARTERIAL CHEMORADIATION; INDUCTION
   CHEMOTHERAPY; OROPHARYNGEAL CANCER; RADIOTHERAPY; CHEMORADIOTHERAPY;
   IMPACT
AB Background: Dysphagia is a common side effect following chemoradiation therapy (CRT) in patients with head and neck cancer (HNC). Methods: In this retrospective case series, 10 patients with HNC were treated with acupuncture for radiation-induced dysphagia and xerostomia. All patients were diagnosed with stage III/IV squamous cell carcinoma. In all, 7 of 10 patients were percutaneous endoscopic gastrostomy (PEG) tube dependent when they began acupuncture. Manual acupuncture and electroacupuncture were used once a week. Results: A total of 9 of 10 patients reported various degrees of subjective improvement in swallowing functions, xerostomia, pain, and fatigue levels. Overall, 6 (86%) of 7 PEG tube-dependent patients had their feeding tubes removed after acupuncture, with a median duration of 114 days (range 49 to 368 days) post CRT. One typical case is described in detail. Conclusions: A relatively short PEG tube duration and reduced symptom severity following CRT were observed in these patients. Formal clinical trials are required to determine the causality of the observations.
C1 [Lu, Weidong] Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, Boston, MA 02115 USA.
   [Lu, Weidong; Wayne, Peter] Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard Medical School
RP Lu, WD (corresponding author), Dana Farber Canc Inst, Leonard P Zakim Ctr Integrat Therapies, 44 Binney St, Boston, MA 02115 USA.
EM weidong_lu@dfci.harvard.edu
RI Lu, Weidong/C-3844-2008
OI Lu, Weidong/0000-0003-2838-6307; Haddad, Robert/0000-0003-1413-0079
FU National Center for Complementary and Alternative Medicine (NCCAM)
   [1K01AT004415-01]
FX This work was supported by the National Center for Complementary and
   Alternative Medicine (NCCAM) Grant No. 1K01AT004415-01.
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   Zhang W, 2002, ZHONGUO ZHEN JIU, V22, P405
   Zheng P, 2002, CHIN J INFORM TRADIT, V9, P63
   Zhou H, 2006, CHIN J REHABIL THEOR, V12, P58
NR 39
TC 18
Z9 22
U1 1
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2010
VL 9
IS 3
BP 284
EP 290
DI 10.1177/1534735410378856
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 653LD
UT WOS:000282091900007
PM 20713374
OA gold
DA 2026-01-16
ER

PT J
AU Chen, CT
   Lin, JG
   Huang, CP
   Lin, YW
AF Chen, Chao-Tsung
   Lin, Jaung-Geng
   Huang, Chun-Ping
   Lin, Yi-Wen
TI Electroacupuncture attenuates chronic fibromyalgia pain through the
   phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse
   brain
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Dorsal root ganglion; Electroacupuncture; Fibromyalgia;
   Phosphatidylinositol; Somatosensory cortex; Thalamus; 3-kinase
ID NEUROPATHIC PAIN; BETA-ENDORPHIN; AMPA RECEPTORS; ACUPUNCTURE;
   MECHANISMS; MEDIATE; KINASE; IL-6
AB Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used to treat FM, the results are unsatisfying. In the present study we assessed whether electroacupuncture (EA) can reduce chronic FM pain and then proposed an underlying mechanism for this effect.
   Materials and Methods: Chronic FM pain was induced in mice by dual acid saline injection lasting up to 4 weeks.
   Results: Chronic FM pain was treated by EA manipulation, but not in the sham operated group. Phosphorylated phosphatidylinositol 3-kinase (pPI3K), protein kinase B, mechanistic target of rapamycin, and nuclear factor kappa-light-chain-enhancer of activated B cells were unaltered in the mouse dorsal root ganglion (DRG) and spinal cord (SC) after inducing FM and administering EA treatment. The pPI3K-associated nociceptive signaling pathway was increased in the thalamus of FM mice, but reversed by EA. Similar results were observed in the mouse somatosensory cortex.
   Conclusion: These data suggest that EA has a significant effect on a signaling pathway in brain areas of FM mice. These findings suggest the value of EA for clinical practice.
C1 [Chen, Chao-Tsung] Chung Yuan Christian Univ, Ctr Gen Educ, Taoyuan 32023, Taiwan.
   [Lin, Jaung-Geng] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 40402, Taiwan.
   [Huang, Chun-Ping; Lin, Yi-Wen] China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
C3 Chung Yuan Christian University; China Medical University Taiwan; China
   Medical University Taiwan
RP Lin, YW (corresponding author), China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.; Lin, YW (corresponding author), China Med Univ, Chinese Med Res Ctr, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM yiwenlin@mail.cmu.edu.tw
OI Huang, Chun-Ping/0000-0002-3363-964X
FU "Chinese Medicine Research Center, China Medical University" from The
   Featured Areas Research Center Program within Ministry of Education
   (MOE) in Taiwan [CMRC-CENTER-0]; MOST [107-2320-B-039-033]; 
   [CMU107-S-39]
FX This study was financially supported by the "Chinese Medicine Research
   Center, China Medical University" from The Featured Areas Research
   Center Program within the framework of the Higher Education Sprout
   Project by the Ministry of Education (MOE) in Taiwan (CMRC-CENTER-0),
   MOST 107-2320-B-039-033, and CMU107-S-39.
CR ANDERSSON SA, 1973, LANCET, V2, P564
   Chang FC, 2004, J BIOMED SCI, V11, P179, DOI 10.1159/000076030
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NR 31
TC 6
Z9 6
U1 0
U2 1
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD SEP
PY 2019
VL 22
IS 9
BP 1085
EP 1090
DI 10.22038/ijbms.2019.35887.8547
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IM1ER
UT WOS:000477731900015
PM 31807253
DA 2026-01-16
ER

PT J
AU Zheng, KH
   Hong, XP
   Jiang, CY
   Chen, Y
AF Zheng, Kanghua
   Hong, Xiaoping
   Jiang, Changyin
   Chen, Yong
TI Effects of warming needle moxibustion on postoperative rehabilitation,
   pain degree, immune function, and upper limb lymphedema in patients with
   breast cancer undergoing radical mastectomy
SO AMERICAN JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE Functional rehabilitation training; warming needle moxibustion; radical
   mastectomy; upper limb lymph edema; immune function
ID ACUPUNCTURE
AB This study aims to evaluate the effects of warm acupuncture combined with conventional functional rehabilitation training (FRT) on the recovery of breast cancer (BC) patients following radical mastectomy, focusing on immune function, pain management, and quality of life (QoL). This retrospective study involved 118 BC patients who underwent radical surgery at the Second People's Hospital Affiliated to Fujian University of Chinese Medicine between January 2022 and May 2024. The included patient were assigned into an experimental group (EG, n=62, warm acupuncture in conjunction with conventional FRT) and a control group (CG; n=56; conventional FRT only). of hospital stay, upper limb mobility, immune function indicators, and pain scores, were compared between the two groups. Multivariate logistic regression was employed to identify factors affecting treatment outcomes. The EG demonstrated significantly lower visual analog scale (VAS) scores at post-operative 2, 4, and 8 weeks compared to the CG (all P < 0.05). The incidence of upper limb lymphedema in the EG was 9.26%, notably lower than the 24.07% observed in the CG (P < 0.05). Immune function indicators, including CD3(+), CD4(+), CD8(+), and the CD4(+)/CD8(+) ratio, were significantly higher in the EG postoperatively (P < 0.05). Furthermore, the EG reported significantly improved scores in role physical, general health, vitality, social functioning, role emotional, mental health, and physiological functioning, alongside significantly lower scores in bodily pain compared to the CG (all P < 0.05). Multivariate logistic regression analysis revealed CD3(+) and CD4(+)/CD8(+) ratio as independent factors affecting patient treatment efficacy (both P < 0.05). In conclusion, the combination of warm acupuncture and conventional FRT significantly enhances immune function, pain management, and overall QoL in BC patients after surgery, with CD3(+) and CD4(+)/CD8(+) ratios being crucial factors influencing recovery.
C1 [Zheng, Kanghua; Hong, Xiaoping; Jiang, Changyin] Fujian Univ Chinese Med, Peoples Hosp 2, Dept Rehabil, Fuzhou 350003, Fujian, Peoples R China.
   [Chen, Yong] Fujian Univ Tradit Chinese Med, Coll Integrat Med, Dept Pathophysiol, 1 Qiuyang Rd, Fuzhou 350122, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Chen, Y (corresponding author), Fujian Univ Tradit Chinese Med, Coll Integrat Med, Dept Pathophysiol, 1 Qiuyang Rd, Fuzhou 350122, Fujian, Peoples R China.
EM chenyong1209c@163.com
CR Bao T, 2023, BREAST CANCER RES TR, V202, P287, DOI 10.1007/s10549-023-07072-1
   Ben-Dror J, 2022, GENES-BASEL, V13, DOI 10.3390/genes13060960
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NR 26
TC 0
Z9 0
U1 1
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2156-6976
J9 AM J CANCER RES
JI Am. J. Cancer Res.
PY 2025
VL 15
IS 3
BP 991
EP 1001
DI 10.62347/YXHG6188
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2BZ8G
UT WOS:001479045400009
PM 40226461
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Yeh, CH
   Chien, LC
   Lin, WC
   Bovbjerg, DH
   van Londen, GJ
AF Yeh, Chao Hsing
   Chien, Lung-Chang
   Lin, Wei-Chun
   Bovbjerg, Dana Howard
   van Londen, G. J.
TI Pilot Randomized Controlled Trial of Auricular Point Acupressure to
   Manage Symptom Clusters of Pain, Fatigue, and Disturbed Sleep in Breast
   Cancer Patients
SO CANCER NURSING
LA English
DT Article
DE Auricular point acupressure; Breast cancer patient; Symptom cluster
ID QUALITY-OF-LIFE; BEHAVIORAL-THERAPY; ACUPUNCTURE; INTERVENTION;
   DISTRESS; ONCOLOGY; RADIOTHERAPY; FEASIBILITY; PREVALENCE; DEPRESSION
AB Background: Current management for a symptom cluster of pain, fatigue, and disturbed sleep in breast cancer patients has limited effects.
   Objective: The purposes of this prospective, randomized controlled pilot study were to (1) assess the feasibility and tolerability of auricular point acupressure (APA) intervention to manage pain, fatigue, and sleep disturbance in breast cancer patients and (2) provide an initial appraisal of effect size as compared with a control intervention.
   Methods: Thirty-one participants were randomized into either an active APA group (n = 16) or a control APA group (n = 15), which included the sham APA treatment not related to the symptoms. All participants received the APA once a week for 4 weeks. Self-report measures were obtained at baseline, weekly during intervention, at end of intervention, and at a 1-month follow-up.
   Results: For the 4-week of APA treatment, the retention rate was 88% for the active APA group and 73% for the control APA group. After 4 weeks of APA, participants in the active APA treatment had reported a reduction of 71% in pain, 44% in fatigue, 31% in sleep disturbance, and 61% in interference with daily activities. The control APA group experienced some moderate reduction in these symptoms.
   Conclusion: Given that this was a pilot study with a small sample size, results must be interpreted with caution.
   Implications for Practice: Our results suggest that APA may provide an inexpensive and effective complementary approach for the management of symptom clusters for breast cancer patients, and further study is warranted.
C1 [Yeh, Chao Hsing; Lin, Wei-Chun] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
   [Chien, Lung-Chang] Univ Texas San Antonio, Dept Biostat, San Antonio, TX USA.
   [Bovbjerg, Dana Howard] Univ Pittsburgh, Biobehav Oncol Program, Pittsburgh, PA USA.
   [van Londen, G. J.] Univ Pittsburgh, Dept Med, Med Ctr, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Texas System; University of Texas at San
   Antonio; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Yeh, CH (corresponding author), Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
EM yehc@pitt.edu
OI van Londen, GJ/0000-0001-6047-6172; Lin, Wei-Chun/0000-0002-2226-4619
FU American Cancer Society [124638-PEP-13-237-01-PCSM]; National Institute
   on Aging [T32AG021885] Funding Source: NIH RePORTER
FX This study was supported by a grant to C.H.Y. from the American Cancer
   Society (grant 124638-PEP-13-237-01-PCSM).
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NR 49
TC 74
Z9 95
U1 2
U2 56
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD SEP-OCT
PY 2016
VL 39
IS 5
BP 402
EP 410
DI 10.1097/NCC.0000000000000303
PG 9
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA DW9LX
UT WOS:000383982600014
PM 26390073
DA 2026-01-16
ER

PT J
AU Chen, L
   Li, MY
   Fan, L
   Zhu, XP
   Liu, JH
   Li, H
   Xu, ZH
   Chen, JJ
   Liang, ZH
   Liu, ZY
   Feng, LM
   Chen, XY
   He, Q
   Chen, XK
   Ou, AH
   He, JS
   Ma, R
   Ning, BL
   Jiang, L
   Li, S
   Fu, WB
AF Chen, Ling
   Li, Minying
   Fan, Li
   Zhu, Xiaoping
   Liu, Jianhua
   Li, Hui
   Xu, Zhenhua
   Chen, Junjun
   Liang, Zhaohui
   Liu, Zhiyan
   Feng, Lingmei
   Chen, Xiaoyun
   He, Qing
   Chen, Xiaokai
   Ou, Aihua
   He, Jiangshan
   Ma, Rui
   Ning, Baile
   Jiang, Li
   Li, Sheng
   Fu, Wenbin
TI Optimized acupuncture treatment (acupuncture and intradermal needling)
   for cervical spondylosis-related neck pain: a multicenter randomized
   controlled trial
SO PAIN
LA English
DT Article
DE Cervical spondylosis-related neck pain; Optimized acupuncture treatment;
   Shallow acupuncture; Sham acupuncture
ID QUALITY-OF-LIFE; BREAST-CANCER; MCGILL PAIN; TASK-FORCE; JOINT PAIN;
   USUAL CARE; QUESTIONNAIRE; ELECTROACUPUNCTURE; DISABILITY; PROTOCOL
AB Cervical spondylosis (CS)-related neck pain is difficult to treat because of its degenerative nature. The aim of this 9-center, single-blinded, randomized controlled trial was to evaluate the efficacy of optimized acupuncture for CS-related neck pain. Participants who met the inclusion criteria were randomized to optimized, shallow, and sham acupuncture groups (1:1:1). The primary outcome was the change from baseline in the Northwick Park Neck Pain Questionnaire score at week 4. Participants were followed up until week 16. Of the 896 randomized participants, 857 received >= 1 intervention session; 280, 286, and 291 received optimized, shallow, and sham acupuncture, respectively. A total of 835 (93.2%) participants completed the study. At week 4, significant differences (P < 0.001) were observed in the changes in Northwick Park Neck Pain Questionnaire scores between the optimized acupuncture group and both the shallow {7.72 (95% confidence interval [CI], 5.57-9.86)} and sham acupuncture (10.38 [95% CI, 8.25-12.52]) groups. The difference in the scores at week 16 between the optimized acupuncture group and the shallow (8.84 [95% CI, 6.34-11.34]) and sham acupuncture (10.81 [95% CI, 8.32-13.30]) groups were significant. The center effect indicated wide variability in the treatment effects (Cohen's d = 0.01-2.19). Most SF-36 scores were higher in the optimized acupuncture group than those in the other groups. These results suggest that 4-week optimized acupuncture treatment alleviates CS-related neck pain and improves the quality of life, with the effects persisting for minimum 3 months. Therefore, acupuncture can have positive effects on CS-related neck pain, although the effect size may vary widely.
C1 [Chen, Ling; Zhu, Xiaoping; Liu, Jianhua; Li, Hui; Xu, Zhenhua; Ma, Rui; Ning, Baile; Jiang, Li; Li, Sheng; Fu, Wenbin] Guangzhou Univ Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp 2, 111 Dade Rd, Guangzhou, Guangdong, Peoples R China.
   [Chen, Ling; Li, Minying; He, Jiangshan] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Fan, Li] Guangzhou Univ Chinese Med, Dept Tradit Therapy Ctr, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Chen, Junjun] Hunan Univ Tradit Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp 1, Changsha, Peoples R China.
   [Liang, Zhaohui] York Univ, Toronto, ON, Canada.
   [Liu, Zhiyan] Xinjiang Uygur Autonomous Reg Hosp Tradit Chinese, Dept Acupuncture & Moxibust, Urumqi, Peoples R China.
   [Feng, Lingmei] Guizhou Univ Tradit Chinese Med, Dept Acupuncture & Massage, Guiyang, Peoples R China.
   [Chen, Xiaoyun] Hainan Gen Hosp, Dept Acupuncture & Moxibust, Haikou, Hainan, Peoples R China.
   [He, Qing] Yan Chai Hosp Cum Hong Kong Baptist Univ Yan Chai, Chinese Med Ctr Training & Res, Hong Kong, Peoples R China.
   [Chen, Xiaokai] Guangzhou Med Univ, Huizhou Peoples Hosp 3, Huizhou, Peoples R China.
   [Ou, Aihua] Guangzhou Univ Chinese Med, Dept Big Data Res Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Fu, Wenbin] Shenzhen Baoan Res Ctr Acupuncture & Moxibust, Shenzhen, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Hunan
   University of Chinese Medicine; York University - Canada; Guizhou
   University of Traditional Chinese Medicine; Hainan Medical University;
   Guangzhou Medical University; Guangzhou University of Chinese Medicine
RP Fu, WB (corresponding author), Guangzhou Univ Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp 2, 111 Dade Rd, Guangzhou, Guangdong, Peoples R China.
EM fuwenbin@gzucm.edu.cn
RI Liang, Zhaohui/Q-8443-2019; 贺, 晴/ISS-3561-2023; Zhu,
   Xiaoping/AAO-2711-2021; xu, zhenhua/KEH-3306-2024
OI Liang, Zhaohui/0000-0002-9361-5535; He, Jiangshan/0000-0002-4121-6241; 
FU Ministry of Science and Technology of the People's Republic of China
   through the Eleventh Five-Year National Science and Technology Pillar
   Program [2006BAI12B04-1]; Sanming Project of Medicine in Shenzhen
   [SZSM201806077]; China Postdoctoral Science Foundation [2019M652867];
   Foundation for Basic and Applied Basic Research of Guangdong Province
   [2019M652867]; Scientific Research Project of Guangdong Traditional
   Chinese Medicine Bureau [20201118]
FX This study was supported by the Ministry of Science and Technology of
   the People's Republic of China through the Eleventh Five-Year National
   Science and Technology Pillar Program (Grant no. 2006BAI12B04-1),
   Sanming Project of Medicine in Shenzhen (Grant no. SZSM201806077), China
   Postdoctoral Science Foundation Funded Project (Grant no. 2019M652867),
   Foundation for Basic and Applied Basic Research of Guangdong Province
   (Grant no. 2019M652867), and Scientific Research Project of Guangdong
   Traditional Chinese Medicine Bureau (Grant no. 20201118).
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NR 41
TC 32
Z9 39
U1 11
U2 78
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD MAR
PY 2021
VL 162
IS 3
BP 728
EP 739
DI 10.1097/j.pain.0000000000002071
PG 12
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA SL0UO
UT WOS:000656631900009
PM 32947547
DA 2026-01-16
ER

PT J
AU Samuels, N
   Ben-Arye, E
AF Samuels, Noah
   Ben-Arye, Eran
TI Integrative Medicine for Cancer-Related Pain: A Narrative Review
SO HEALTHCARE
LA English
DT Review
DE cancer-related pain; complementary integrative medicine; acupuncture;
   touch therapies; mind-body-medicine; herbal supplements; pragmatic
   research
ID COMPOUND KUSHEN INJECTION; SYMPTOM BURDEN; ACUPUNCTURE; COMPLEMENTARY;
   THERAPY; SAFETY; MANAGEMENT; MASSAGE; IMPACT; CARE
AB Cancer-related pain (C-RP) is a prevalent and debilitating concern among patients with cancer, with conventional treatments limited in their ability to provide adequate relief, and by the adverse effects associated with their use. Complementary and integrative medicine (CIM) modalities have been shown to be potentially effective and safe for the treatment of pain and related symptoms, when used in conjunction with conventional medications and under medical supervision. An increasing number of oncology centers provide CIM within their conventional supportive and palliative care service, in an "Integrative Oncology" (IO) setting. A large body of clinical research, including systematic reviews and guidelines such as those published in 2022 by the Society for Integrative Oncology (SIO), in collaboration with the American Society for Clinical Oncology (ASCO), support the use of some CIM modalities for C-RP and related concerns. These include acupuncture for general and peri-operative/procedural pain, as well as aromatase inhibitor-associated arthralgia (AIA); reflexology or acupressure for pain during systemic therapy for cancer; hypnosis for procedural pain or pain due to diagnostic workup; and massage for pain experienced by patients during palliative and hospice care. Further research is needed, within both randomized control trials and pragmatic non-controlled studies which are more reflective of the real-life IO setting. This review summarizes the evidence supporting the use of CIM for C-RP; the analgesic mechanism of the modalities presented; and the challenges facing IO researchers, as well as the implementation of the 2022 SIO-ASCO guideline recommendations.
C1 [Samuels, Noah] Hebrew Univ Jerusalem, Fac Med, Ctr Integrat Complementary Med, Shaare Zedek Med Ctr, IL-9103102 Jerusalem, Israel.
   [Ben-Arye, Eran] Clalit Hlth Serv, Integrat Oncol Program, Oncol Serv, Lin Carmel & Zebulun Med Ctr, IL-3535152 Haifa, Israel.
   [Ben-Arye, Eran] Technion Israel Inst Technol, Fac Med, Dept Family Med, IL-3200003 Haifa, Israel.
C3 Hebrew University of Jerusalem; Shaare Zedek Medical Center; Clalit
   Health Services; Technion Israel Institute of Technology
RP Samuels, N (corresponding author), Hebrew Univ Jerusalem, Fac Med, Ctr Integrat Complementary Med, Shaare Zedek Med Ctr, IL-9103102 Jerusalem, Israel.
EM noahs@szmc.org.il; eranben@netvision.net.il
OI Samuels, Noah/0000-0002-1122-9607; Ben-Arye, Eran/0000-0002-4058-3672
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NR 83
TC 4
Z9 5
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD FEB
PY 2024
VL 12
IS 3
AR 403
DI 10.3390/healthcare12030403
PG 13
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA HO1M4
UT WOS:001160353700001
PM 38338288
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, SL
   Yan, ZK
   Huang, W
AF Li, Suli
   Yan, Zhongkai
   Huang, Wei
TI Effects of Huolong moxibustion on discogenic low back pain
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Huolong moxibustion; DLBP; curative effect; inflammatory factor
ID ACUPUNCTURE; MANAGEMENT
AB Objective: The goal of this study was to investigate the effect of Huolong moxibustion in the treatment of discogenic low back pain (DLBP) and its underlying mechanisms. Methods: One hundred and forty-eight patients with DLBP treated in the Orthopedics Department of Tangshan Gongren Hospital were selected and randomly divided into the observation group and control group. Patients in the control group were treated with regular treatment such as conventional traction and manual massage physiotherapy, while those in the observation group were treated with Huolong moxibustion based on the treatment in control group for 3 weeks. The two groups were compared in the treatment effect of DLBP, and visual analogue scale (VAS) score, Japanese Orthopedic Association (JOA) score, oswestry disability index (ODI) score, 36-Item Short-Form Health Survey (SF-36) score and serum inflammatory factors. Results: At 3 weeks after treatment, the total effective rate was 97.37% in observation group and 88.39% in control group, and there was a statistical difference between two groups (P=0.04). At 3 weeks after treatment, VAS score and ODI score in the observation group were remarkably lower than those in the control group (both P<0.001); JOA score and SF-36 score were also significantly increased (both P<0.001). Additionally, interleukin-2 (IL-2), IL-10, and tumor necrosis factor a (TNF-alpha) in the observation group was significantly lower than those in the control group (P<0.001). Conclusion: Huolong moxibustion shows efficacy in the treatment of DLBP, which is helpful to alleviate the symptoms of lumbago and improve the quality of life of patients. This might be associated with lower serum IL-6 and TNF-alpha expression levels.
C1 [Li, Suli; Yan, Zhongkai; Huang, Wei] Tangshan Gongren Hosp, Dept Tradit Chinese Med, 34 Longzenan Rd, Tangshan 063000, Hebei, Peoples R China.
RP Yan, ZK (corresponding author), Tangshan Gongren Hosp, Dept Tradit Chinese Med, 34 Longzenan Rd, Tangshan 063000, Hebei, Peoples R China.
EM yanzhongkai27j@163.com
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NR 27
TC 2
Z9 2
U1 1
U2 16
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 7
BP 8936
EP 8942
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IM4UR
UT WOS:000477991300115
DA 2026-01-16
ER

PT J
AU Ji, Z
   Niu, HY
   He, AQ
   Li, KY
   Jia, JY
   Zhang, MR
   Liu, G
AF Ji, Zhe
   Niu, Heyuan
   He, Anqi
   Li, Kaiyu
   Jia, Jinyan
   Zhang, Maorun
   Liu, Gang
TI Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric
   analysis from 2004 to 2024
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Article
DE acupuncture; bibliometric analysis; cancer; citespace; VOSviewer
ID POSTOPERATIVE ILEUS PATHOPHYSIOLOGY; SIGNALING PATHWAY
AB Background: Acupuncture is increasingly recognized as a promising intervention modality in cancer treatment. Nevertheless, there has been a paucity of systematic analysis and visualisation of relevant publications through bibliometric methods. This paper conducts a bibliometric analysis of research on acupuncture within the realm of oncological applications, aiming to explore its prospects and emerging trends. Methods: In this study, we analyzed 2117 documents obtained from the Web of Science Core Collection (WOSCC) to examine the correlations among authors, journals, institutions, countries, and keywords. This analysis was conducted using the Bibliometric R package, CiteSpace, and VOSviewer software. Results: The evolution of acupuncture can be broadly divided into three time periods: 2004-2008, 2009-2017 and 2018-2024. The WOSCC retrieved 2117 publications on acupuncture for cancer over the past 20 years. Among the top 10 institutions, seven were from the United States, two from China, and one from Korea. Memorial Sloan Kettering Cancer Center had the highest number of publications. At the same time, the journal INTEGRATIVE CANCER THERAPIES published the most articles in this field. Keyword co-occurrence analysis revealed four distinct clusters: "Alternative and Complementary Medicine for Cancer", "Acupuncture for cancer-related fatigue and pain", "Acupressure for anxiety, depression, and insomnia", "Improving quality of life for breast cancer patients". The most recent keyword outbreaks included "sleep", "radiation induced xerostomia", "recovery", "insomnia", and "induced peripheral neuropathy." Breast cancer is the type of cancer for which acupuncture is most commonly used. Conclusion: The future research focus will be on acupuncture as a treatment for sleep disorders, the alleviation of radiotherapy complications and the improvement of postoperative quality of life. Research on acupuncture in the field of breast cancer is more extensive compared to other cancers. Therefore, it is necessary to strengthen research on acupuncture in different cancer types.
C1 [Ji, Zhe; Niu, Heyuan; He, Anqi; Li, Kaiyu; Jia, Jinyan; Zhang, Maorun; Liu, Gang] Tianjin Med Univ, Gen Hosp, Dept Gen Surg, Tianjin, Peoples R China.
C3 Tianjin Medical University
RP Liu, G (corresponding author), Tianjin Med Univ, Gen Hosp, Dept Gen Surg, Tianjin, Peoples R China.
EM lg1059@tmu.edu.cn
RI JIA, Jinyan/GSN-2611-2022; Li, Kaiyu/PCS-6518-2025
FU Tianjin Key Medical Discipline (Specialty) Construction Project
   [TJYXZDXK-005A]
FX Funded by Tianjin Key Medical Discipline (Specialty) Construction
   Project (TJYXZDXK-005A) .
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NR 59
TC 2
Z9 2
U1 10
U2 30
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2025
VL 18
BP 531
EP 547
DI 10.2147/JMDH.S494138
PG 17
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA W1F4G
UT WOS:001416115800001
PM 39911755
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, SW
   Li, YY
   Liang, ZD
   Dai, JX
   Huang, H
   Zhang, HH
   Yang, B
   Wang, JH
   Tang, DX
AF Zhang, Shaowang
   Li, Yuanyin
   Liang, Zhide
   Dai, Jiaxing
   Huang, Hong
   Zhang, Huanghui
   Yang, Bing
   Wang, Jinghui
   Tang, Dongxin
TI Comparing the effects of different non-pharmacological traditional
   Chinese medicine therapies on cancer survivors: A Bayesian Network
   Meta-analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Non-pharmacological traditional Chinese; medicine therapies; Network
   Meta-Analysis; Cancer survivors; Pain; Fatigue
ID QUALITY-OF-LIFE; MASSAGE THERAPY; TAI CHI; INTERVENTIONS; MANAGEMENT;
   QIGONG; INCONSISTENCY; STATEMENT; FATIGUE; PAIN
AB Objectives: Several studies have demonstrated the positive impact of non-pharmacological Traditional Chinese Medicine (TCM) therapies on pain, fatigue, sleep quality, and quality of life in cancer survivors. However, no research has compared the effectiveness of these therapies. This study aims to compare various interventions and identify the most effective non-pharmacological TCM therapies to provide evidence-based recommendations for cancer survivors. Methods: A systematic search was conducted in PubMed, Embase, Web of Science, CNKI, and Wanfang Data. RCTs investigating the effects of Taichi, Qigong, acupuncture, acupressure, TCM emotional therapy, and mixed therapies as interventions for cancer survivors were screened was conducted. Data from the creation of the database to February 2025 were included. Two independent reviewers evaluated the study quality. A Bayesian Network Meta-analysis was conducted to carry out a random effects model. Results: Seventy-one RCTs involving 6473 patients were included in the analysis. Network meta-analysis showed significance for all five intervention therapies in pain control in cancer patients. The best efficacy was observed for acupressure (SMD=-1.1 [-1.55,-0.66]) and Taichi/Qigong (SMD=-1.08[-1.64,-0.53]), followed by TCM emotional therapy (SMD=-0.93 [-1.42,-0.44]) and acupuncture (SMD=-0.54 [-0.93,-0.15]), with the latter showing comparatively lower efficacy. None of the interventions demonstrated superior efficacy in improving fatigue compared to the control group. Mixed therapies (SMD=-1.36[-2.56,-0.28]) demonstrated the greatest effect in improving sleep quality. Taichi/Qigong (SMD=1.87 [0.96, 2.83]) demonstrated certain advantages in improving quality of life. However, acupuncture and TCM emotional therapy had no significant effect on sleep quality or overall quality of life. Conclusion: The evidence from this study suggests that acupressure and Taichi/Qigong are recommended as the most effective therapies for pain relief and quality of life improvement, respectively. The efficacy of these therapies for fatigue remains inconclusive. However, due to the limited number of included studies and the high risk of bias, these results should be interpreted with caution. Future studies should include more rigorously designed high-quality randomized controlled trials to confirm their long-term efficacy and safety. Registration: PROSPERO CRD42024601976
C1 [Zhang, Shaowang; Li, Yuanyin; Dai, Jiaxing; Huang, Hong; Zhang, Huanghui; Yang, Bing; Wang, Jinghui; Tang, Dongxin] Guizhou Univ Tradit Chinese Med, Huaxi Campus, Guiyang 550000, Peoples R China.
   [Yang, Bing; Wang, Jinghui; Tang, Dongxin] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Guiyang 550000, Peoples R China.
   [Zhang, Shaowang; Li, Yuanyin; Dai, Jiaxing; Huang, Hong; Zhang, Huanghui; Yang, Bing; Wang, Jinghui; Tang, Dongxin] Talent Base TCM Tumor Inheritance & Sci & Technol, Guiyang 550000, Peoples R China.
   [Liang, Zhide] Qingdao Univ, Coll Phys Educ, Dept Phys Educ, Qingdao 266071, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Guizhou University
   of Traditional Chinese Medicine; Qingdao University
RP Wang, JH; Tang, DX (corresponding author), Guizhou Univ Tradit Chinese Med, Huaxi Campus, Guiyang 550000, Peoples R China.; Wang, JH (corresponding author), Guizhou Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Guiyang 550000, Peoples R China.
EM zhangsw1114@163.com; 1240722076@qq.com; liangzhide123@163.com;
   1229607910@qq.com; 1527005190@qq.com; 1257379762@qq.com;
   1006019442@qq.com; 547917662@qq.com; hemingankang@sina.com
RI dai, jiaxing/KCK-9047-2024; Liang, Zhide/OFM-4765-2025
FU Guizhou Provincial Higher Education Traditional Chinese and Medicine
   Ethnic Medicine Cancer Prevention and Treatment Medical Transformation
   Engineering Research Center (Qian Jijiao [2023]) [037]; Talent Base of
   Traditional Chinese Medicine Tumor Inheritance and Scientific and
   Technological Innovation in Guizhou Province (Guizhou Qianren Lingfa
   [2018]) [3]; Talent Team of Traditional Chinese Medicine Tumor
   Inheritance and Scientific and Technological Innovation in Guizhou
   Province (Guizhou Science and Technology Cooperative Talent [2020])
   [5013]; Guizhou Science and Technology Cooperation Academic New Seedling
   ([2023]) [03]
FX Guizhou Provincial Higher Education Traditional Chinese and Medicine
   Ethnic Medicine Cancer Prevention and Treatment Medical Transformation
   Engineering Research Center (Qian Jijiao [2023] No.037);Talent Base of
   Traditional Chinese Medicine Tumor Inheritance and Scientific and
   Technological Innovation in Guizhou Province (Guizhou Qianren Lingfa
   [2018] No.3);Talent Team of Traditional Chinese Medicine Tumor
   Inheritance and Scientific and Technological Innovation in Guizhou
   Province (Guizhou Science and Technology Cooperative Talent [2020] No.
   5013);Study on Mechanisms of Bone Cancer Pain Intervention by Bufo
   Spirit Cream through Regulation of Research on the mechanism of JNK
   pathway intervention in bone cancer pain by regulating the "intestinal
   flora" of toad spirit cream (Guizhou Science and Technology Cooperation
   Academic New Seedling ([2023] No.03)).
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NR 58
TC 1
Z9 1
U1 3
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2025
VL 90
AR 103164
DI 10.1016/j.ctim.2025.103164
EA MAR 2025
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0ZL1V
UT WOS:001459676900001
PM 40157553
OA gold
DA 2026-01-16
ER

PT J
AU Fu, YM
   Yang, YC
   Zhang, J
   Zhao, JJ
   Liu, GY
   Ling, S
   Wang, C
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   Yang, NN
   Liu, CZ
   Pei, W
AF Fu, Yi-Ming
   Yang, Ying-Chi
   Zhang, Jing
   Zhao, Jingjie
   Liu, Gong-Yong
   Ling, Shen
   Wang, Chao
   Wang, Li-Wei
   Yang, Yu-Tong
   Wang, Yu
   Yang, Na-Na
   Liu, Cun-Zhi
   Pei, Wei
TI Preoperative electroacupuncture versus sham electroacupuncture for the
   treatment of postoperative ileus after laparoscopic surgery for
   colorectal cancer in China: a study protocol for a multicentre,
   randomised, sham-controlled trial
SO BMJ OPEN
LA English
DT Article
DE complementary medicine; colorectal surgery; gastroenterology
ID ACUPUNCTURE; ANXIETY; PATHWAY; SCALE; PAIN
AB Introduction Postoperative ileus (POI) is a postoperative complication that can cause lingering recovery after colorectal resection and a heavy healthcare system burden. Acupuncture aims to prevent postoperative complications, reduce the duration of POI, help recovery and shorten hospital stays. We hypothesise that preoperative electroacupuncture (EA) can promote POI recovery under the enhanced recovery after surgery protocol after laparoscopic surgery in patients with POI.Methods and analysis This is a multicentre, randomised, sham-controlled trial. A total of 80 patients will be enrolled and randomly assigned to the EA or sham electroacupuncture (SA) group. The eligible patients will receive EA or SA for one session per day with treatment frequency starting on preoperative day 1 for four consecutive days. The primary outcome is the time to first defecation. The secondary outcomes include the time to first flatus, length of postoperative hospital stay, time to tolerability of semiliquid and solid food, postoperative nausea, vomiting, pain and extent of abdominal distention, time to first ambulation, preoperative anxiety, 30-day readmission rate, the usage of anaesthetics and analgesics during operation, length of postanaesthesia care unit stay. A mechanistic study by single-cell RNA sequencing in which postintervention normal intestinal tissue samples will be collected. The results of this study will provide evidence of the effects of acupuncture on POI and promote good clinical decision to millions of patients globally every year.Ethics and dissemination This study has been approved by the ethical application of Beijing University of Chinese Medicine (2022BZYLL0401), Beijing Friendship Hospital Affiliated to Capital Medical University(2022-P2-368-02), Cancer Hospital Chinese Academy of Medical Science (23/175-3917), Huanxing Cancer Hospital (2023-002-02). The results will be published in a medical journal. In addition, we plan to present them at scientific conferences.Trial registration number ChiCTR2300077633.
C1 [Fu, Yi-Ming; Wang, Yu; Yang, Na-Na; Liu, Cun-Zhi] Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Yang, Ying-Chi; Zhao, Jingjie; Ling, Shen] Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China.
   [Zhang, Jing; Liu, Gong-Yong; Wang, Chao; Wang, Li-Wei; Yang, Yu-Tong] Huanxing Canc Hosp, Dept Surg, Beijing, Peoples R China.
   [Pei, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Colorectal Surg,Canc Hosp, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Capital Medical University;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Cancer Institute & Hospital - CAMS; Peking Union Medical College
RP Liu, CZ (corresponding author), Beijing Univ Chinese Med, Int Acupuncture & Moxibust Innovat Inst, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.; Pei, W (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Colorectal Surg,Canc Hosp, Beijing, Peoples R China.
EM lcz623780@126.com; peiwei1@sina.com
RI ; Liu, Cunzhi/J-9190-2017; WANG, Yu/OSI-5971-2025; PEI,
   WEI/HNC-0257-2023
OI Zhao, Jingjie/0000-0001-7763-1351; PEI, WEI/0000-0001-5201-6432
FU National Science Foundation for Distinguished Young Scholars [81825024]
FX The authors would like to thank all the staff at the hospitals that
   recruited the participants.
CR Acar HV, 2016, COMPLEMENT THER MED, V29, P48, DOI 10.1016/j.ctim.2016.09.013
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NR 34
TC 0
Z9 0
U1 2
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL
PY 2024
VL 14
IS 7
AR e083460
DI 10.1136/bmjopen-2023-083460
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XY3W7
UT WOS:001265212100039
PM 38969370
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wang, WM
   Liu, Y
   Yang, XF
   Sun, JH
   Yue, ZH
   Lu, DR
   Zhou, KH
   Sun, YJ
   Hou, AH
   Zang, ZW
   Jin, XQ
   Liu, C
   Wang, YH
   Yu, JN
   Zhu, LL
   Liu, ZS
AF Wang, Weiming
   Liu, Yan
   Yang, Xiaofang
   Sun, Jianhua
   Yue, Zenghui
   Lu, Dianrong
   Zhou, Kehua
   Sun, Yuanjie
   Hou, Aihua
   Zang, Zhiwei
   Jin, Xiaoqing
   Liu, Chao
   Wang, Yuhang
   Yu, Jinna
   Zhu, Lili
   Liu, Zhishun
TI Effects of Electroacupuncture for Opioid-Induced Constipation in
   Patients With Cancer in China: A Randomized Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID DOUBLE-BLIND; PLACEBO; PAIN; PRUCALOPRIDE; MULTICENTER; PREVALENCE;
   CHALLENGES; MANAGEMENT; NALOXEGOL
AB IMPORTANCE Opioid-induced constipation (OIC) is prevalent among patients treated with opioids for cancer pain. Safe and effective therapies for OIC in patients with cancer remain an unmet need.
   OBJECTIVE To determine the efficacy of electroacupuncture (EA) for OIC in patients with cancer.
   DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial was conducted at 6 tertiary hospitals in China among 100 adult patients with cancer who were screened for OIC and enrolled between May 1, 2019, and December 11, 2021.
   INTERVENTIONS Patients were randomized to receive 24 sessions of EA or sham electroacupuncture (SA) over 8 weeks and then were followed up for 8 weeks after treatment.
   MAIN OUTCOMES AND MEASURES The primary outcome was the proportion of overall responders, defined as patients who had at least 3 spontaneous bowel movements (SBMs) per week and an increase of at least 1 SBM from baseline in the same week for at least 6 of the 8 weeks of the treatment period. All statistical analyses were based on the intention-to-treat principle.
   RESULTS A total of 100 patients (mean [SD] age, 64.4 [10.5] years; 56 men [56.0%]) underwent randomization; 50 were randomly assigned to each group. Among them, 44 of 50 patients (88.0%) in the EA group and 42 of 50 patients (84.0%) in the SA group received at least 20 (>= 83.3%) sessions of treatment. The proportion of overall responders at week 8 was 40.1%(95% CI, 26.1%-54.1%) in the EA group and 9.0% (95% CI, 0.5%-17.4%) in the SA group (difference between groups, 31.1 percentage points [95% CI, 14.8-47.6 percentage points]; P < .001). Compared with SA, EA provided greater relief for most OIC symptoms and improved quality of life among patients with OIC. Electroacupuncture had no effects on cancer pain and its opioid treatment dosage. Electroacupuncture-related adverse events were rare, and, if any, all were mild and transient.
   CONCLUSIONS AND RELEVANCE This randomized clinical trial found that 8-week EA treatment could increase weekly SBMs with a good safety profile and improve quality of life for the treatment of OIC. Electroacupuncture thus provided an alternative option for OIC in adult patients with cancer.
C1 [Wang, Weiming; Sun, Yuanjie; Yu, Jinna; Zhu, Lili; Liu, Zhishun] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture & Moxibust, Beijing, Peoples R China.
   [Liu, Yan] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ, Beijing, Peoples R China.
   [Yang, Xiaofang; Liu, Chao] Guizhou Univ Tradit Chinese Med, Coll Acumox & Tuina, Guiyang, Peoples R China.
   [Sun, Jianhua; Wang, Yuhang] Nanjing Univ Chinese Med, Dept Acupuncture Rehabil, Affiliated Hosp, Nanjing, Peoples R China.
   [Yue, Zenghui] Hunan Univ Chinese Med, Coll Acupuncture & Tuina, Changsha, Hunan, Peoples R China.
   [Lu, Dianrong] China Acad Chinese Med Sci, Wang Jing Hosp, Dept Oncol, Beijing, Peoples R China.
   [Zhou, Kehua] ThedaCare Reg Med Ctr Appleton, Dept Hosp Med, Appleton, WI USA.
   [Hou, Aihua] Yantai Hosp Tradit Chinese Med, Dept Oncol, Yantai, Peoples R China.
   [Zang, Zhiwei] Yantai Hosp Tradit Chinese Med, Dept Acupuncture, Yantai, Peoples R China.
   [Jin, Xiaoqing] Zhejiang Hosp, Dept Acupuncture, Hangzhou, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Beijing University of Chinese Medicine; Guizhou University of
   Traditional Chinese Medicine; Nanjing University of Chinese Medicine;
   Hunan University of Chinese Medicine; China Academy of Chinese Medical
   Sciences
RP Liu, ZS (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture & Moxibust, 5 Beixiange St, Beijing, Peoples R China.
EM zhishunjournal@163.com
RI ZHOU, Kehua/N-2331-2014; Liu, Yan/KRP-8939-2024; Zhu, Lili/JTT-9093-2023
OI Liu, Yan/0000-0002-6433-0151; Zhu, Lili/0000-0002-7852-6200
FU National Administration of Traditional Chinese Medicine "Project of
   building evidence-based practice capacity for TCM-Project BEBPC-TCM"
   [2019XZZX-ZJ]
FX This study was supported and funded by the 2019 National Administration
   of Traditional Chinese Medicine "Project of building evidence-based
   practice capacity for TCM-Project BEBPC-TCM" (No. 2019XZZX-ZJ)
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NR 42
TC 26
Z9 33
U1 4
U2 27
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD FEB
PY 2023
VL 6
IS 2
AR e230310
DI 10.1001/jamanetworkopen.2023.0310
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q7PS3
UT WOS:001059412800003
PM 36811861
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ackerman, SL
   Lown, EA
   Dvorak, CC
   Dunn, EA
   Abrams, DI
   Horn, BN
   Degelman, M
   Cowan, MJ
   Mehling, WE
AF Ackerman, Sara L.
   Lown, E. Anne
   Dvorak, Christopher C.
   Dunn, Elizabeth A.
   Abrams, Donald I.
   Horn, Biljana N.
   Degelman, Marcia
   Cowan, Morton J.
   Mehling, Wolf E.
TI Massage for Children Undergoing Hematopoietic Cell Transplantation: A
   Qualitative Report
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD-CANCER; SUPPORT PROGRAM;
   SURVIVORS; THERAPY; ACUPUNCTURE; CHEMOTHERAPY; DISABILITIES; MANAGEMENT;
   SYMPTOMS
AB Background. No in-depth qualitative research exists about the effects of therapeutic massage with children hospitalized to undergo hematopoietic cell transplantation (HCT). The objective of this study is to describe parent caregivers' experience of the effects of massage/acupressure for their children undergoing HCT. Methods. We conducted a qualitative analysis of open-ended interviews with 15 parents of children in the intervention arm of a massage/acupressure trial. Children received both practitioner and parent-provided massage/acupressure. Results. Parents reported that their child experienced relief from pain and nausea, relaxation, and greater ease falling asleep. They also reported increased caregiver competence and closeness with their child as a result of learning and performing massage/acupressure. Parents supported a semistandardized massage protocol. Conclusion. Massage/acupressure may support symptom relief and promote relaxation and sleep among pediatric HCT patients if administered with attention to individual patients' needs and hospital routines and may relieve stress among parents, improve caregiver competence, and enhance the sense of connection between parent and child.
C1 [Abrams, Donald I.; Degelman, Marcia; Mehling, Wolf E.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
   [Ackerman, Sara L.] Univ Calif San Francisco, Dept Gen Internal Med, San Francisco, CA 94143 USA.
   [Lown, E. Anne] Alcohol Res Grp EAL, Emeryville, CA 94608 USA.
   [Lown, E. Anne] Univ Calif San Francisco, Dept Physiol Nursing, Sch Nursing, San Francisco, CA 94143 USA.
   [Dvorak, Christopher C.; Dunn, Elizabeth A.; Horn, Biljana N.; Cowan, Morton J.] Univ Calif San Francisco, Div Blood & Marrow Transplant, Dept Pediat, San Francisco, CA 94143 USA.
   [Abrams, Donald I.] Univ Calif San Francisco, Dept Med Hematol & Oncol, San Francisco, CA 94115 USA.
   [Mehling, Wolf E.] Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   Alcohol Research Group; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco
RP Mehling, WE (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
EM mehlingw@ocim.ucsf.edu
RI Dvorak, Christopher/AAX-1630-2020
FU Community Foundation Sonoma County, Santa Rosa, California
FX The authors thank the children and parents who took part in this study;
   the Community Foundation Sonoma County, Santa Rosa, California, that
   sponsored the study; massage practitioners Paula Koepke and Jnani
   Chapman; research assistant Viranjini Gopisetty; nurses on the
   children's hospital transplant unit with Trish Murphy and Sara Okane as
   nurse coordinators. The sponsor of the study was not involved in study
   design, or in the collection, analysis, interpretation, or presentation
   of the information. The authors have no financial or personal
   relationships with any individuals, organizations, or companies that
   might be perceived to bias the work.
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NR 36
TC 20
Z9 26
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 792042
DI 10.1155/2012/792042
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 906VP
UT WOS:000301377200001
PM 22474526
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Zhao, BB
   Jia, HL
   Zhang, SB
   Yang, YZ
   Li, B
   Shi, P
   Fang, GX
AF Zhao, Binbin
   Jia, Hongli
   Zhang, Subing
   Yang, Yuzi
   Li, Bing
   Shi, Pei
   Fang, Gongxi
TI Effect of ultrasound-guided needle knife combined with platelet-rich
   plasma infusion on lumbar muscle strain and prognostic evaluation
SO JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
LA English
DT Article
DE Chronic lumbar muscle strain (CLMS); Ultrasound-guided needle knife
   (UGNK); Platelet-rich plasma (PRP); Quality of life (QOL); Lumbar
   function
ID LOW-BACK-PAIN; DISABILITY; QUESTIONNAIRE; DEGENERATION; EXERCISES; SCALE
AB The study evaluated the effectiveness of ultrasound-guided needle knife (UGNK) combined with platelet-rich plasma (PRP) infusion in treating chronic lumbar muscle strain (CLMS). Ninety-two patients with CLMS treated from January 2023 to January 2024 were randomly divided into a control group (CG, n = 46, simple local injection) and an observation group (OG, n = 46, UGNK with PRP infusion). The study compared treatment outcomes, lumbar range of motion, ultrasound findings, pain levels, lumbar function, serum inflammatory factors, and quality of life (QOL) before and after treatment. The effective rate in the OG (97.83 %) was significantly higher than in the CG (78.26 %, P < 0.05). After treatment, the OG showed a reduced lumbar range of motion, smaller hypoechoic areas, and lower pain scores (Present Pain Intensity [PPI], Visual Analog Scale [VAS], and Pain Rating Index [PRI]) compared to the CG (P < 0.05). The OG also had higher Japanese Orthopaedic Association (JOA) scores and lower Oswestry Disability Index (ODI) scores, indicating improved lumbar function (P < 0.05). Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) were lower in the OG, demonstrating reduced inflammation (P < 0.05). Additionally, QOL scores in the physiology, social relations, psychology, and environment domains were higher in the OG (P < 0.05). In conclusion, UGNK combined with PRP infusion effectively improves clinical symptoms, lumbar function, pain relief, inflammation reduction, and QOL in CLMS patients, suggesting a promising therapeutic approach.
C1 [Zhao, Binbin; Zhang, Subing] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Anesthesia Surg, Harbin City 150040, Heilongjiang Pr, Peoples R China.
   [Jia, Hongli] Northeast Agr Univ Hosp, Med Examinat Ctr, Harbin City 150006, Heilongjiang Pr, Peoples R China.
   [Yang, Yuzi] Harbin Fifth Hosp, Dept Plast Surg, Harbin City 150000, Heilongjiang Pr, Peoples R China.
   [Li, Bing] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Peripheral Vasc Dis, Harbin City 150040, Heilongjiang Pr, Peoples R China.
   [Shi, Pei] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Harbin City 150040, Heilongjiang Pr, Peoples R China.
   [Fang, Gongxi] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Bone Injuries, Harbin City 150040, Heilongjiang Pr, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; Heilongjiang University of Chinese Medicine;
   Heilongjiang University of Chinese Medicine
RP Fang, GX (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Bone Injuries, Harbin City 150040, Heilongjiang Pr, Peoples R China.
EM cgaho@tzc.edu.cn
FU Heilongjiang research project on traditional Chinese medicine
   [ZHY2024-080]; Heilongjiang Health Commis-sion [20232121020210]
FX Heilongjiang research project on traditional Chinese medicine
   (ZHY2024-080) . Research Project of the Heilongjiang Health Commis-sion
   (20232121020210) .
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NR 30
TC 0
Z9 0
U1 5
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1687-8507
J9 J RADIAT RES APPL SC
JI J. Radiat. Res. Appl. Sci.
PD SEP
PY 2025
VL 18
IS 3
AR 101562
DI 10.1016/j.jrras.2025.101562
EA MAY 2025
PG 7
WC Multidisciplinary Sciences; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Radiology, Nuclear Medicine &
   Medical Imaging
GA 2XS4P
UT WOS:001493811600002
OA gold
DA 2026-01-16
ER

PT J
AU Xu, C
   Li, N
   Wu, XL
   Dai, XY
   Yang, ZW
   Sun, QH
   Shi, TY
   Chai, YM
   Pang, DD
   Cheng, K
AF Xu, Chang
   Li, Na
   Wu, Xiaoling
   Dai, Xingye
   Yang, Zhiwen
   Sun, Qianhui
   Shi, Tianyu
   Chai, Yemao
   Pang, Dandan
   Cheng, Kai
TI Effect of electroacupuncture on inflammatory signal expression in local
   tissues of rats with chronic pelvic pain syndrome based on purinergic
   2X7 receptor/NOD-like receptor pyrin domain- containing 3 signal pathway
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
ID CHRONIC NONBACTERIAL PROSTATITIS; NEUROPATHIC PAIN; HYPERALGESIA;
   ACUPOINTS
AB OBJECTIVES: To study the expression of inflammatory signal in local prostate tissue of chronic pelvic pain syndrome (CPPS) rats by electroacupuncture (EA) of Guanyuan (CV4), Zhongji (CV3), Huiyang (BL35) and Sanyinjiao (SP6), and to explore the possible mechanism of anti-inflammatory and analgesic effects of EA. METHODS : A total of 36 Sprague-Dawley male rats were randomly divided into three groups: control, model and EA (n=12 rats/group). The CPPS model was made by injection of CFA into ventral lobes of the prostate (0.1 mL). Electric acupuncture apparatus was applied to stimulate Guanyuan (CV4), Zhongji (CV3), bilateral Huiyang (BL35) and Sanyinjiao (SP6) acupoints in EA group. The general condition of rats was observed and the prostate index (PI) was calculated. The thermal pain threshold was collected after each therapeutic course. Histopathological changes of the prostate tissue were examined by hematoxylin-eosin staining method. The expression levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and prostaglandin E2 (PGE2) in prostatic homogenates were measured by enzyme linked immunosorbent assay (ELISA). Moreover, the expression levels of purinergic 2X7 receptor (P2X7R), NOD-like receptor pyrin domain-containing 3 (NLRP3), caspase-1 and interleukin-18 (IL-18) mRNA were quantified by quantitative real-time polymerase chain reaction.RESULTS: Compared with control group, the PI of rats increased, and the thermal pain threshold decreased significantly in model group. The morphological structure of prostate tissues of rats in model group was severely damaged with a large number of inflammatory cells infiltration. Additionally, the levels of TNF-alpha, IL-1 beta and PGE2 were higher, and the expressions of P2X7R, NLRP3, caspase-1 and IL-18 mRNA were higher than those in control group. After EA treatment, the PI was significantly decreased, the thermal pain threshold was significantly increased, and the tissue damage was significantly improved. The expressions of inflammatory cytokines were lower in EA group, and expression of P2X7R/NLRP3 pathway was down-regulated.CONCLUSION: The effect of EA at Guanyuan (CV4), Zhongji (CV3), Huiyang (BL35) and Sanyinjiao (SP6) can improve inflammation and pain symptoms of CPPS rats induced by Complete Freund's adjuvant (CFA). This suggests that EA at Guanyuan (CV4), Zhongji (CV3), Huiyang (BL35) and Sanyinjiao (SP6) can produce anti-inflammatory analgesia effect by preventing the activation of P2X7R/NLRP3 signal pathway, inhibit the release of inflammatory cytokines in CPPS rats, which may provide a putative novel target for the treatment of CPPS.
C1 [Xu, Chang; Wu, Xiaoling; Dai, Xingye; Yang, Zhiwen; Sun, Qianhui; Shi, Tianyu] Beijing Univ Chinese Med, Univ Chinese Med, Acupuncture & Tuina, Beijing 100029, Peoples R China.
   [Li, Na] Beijing Univ Chinese Med, Sch Acupuncture & Tuina, Expt Sci acupuncture & moxibust teaching & Res Sec, Beijing 100029, Peoples R China.
   [Chai, Yemao] Beijing Univ Chinese Med, Sch Acupuncture & Tuina, Complex Lab, Beijing 100029, Peoples R China.
   [Cheng, Kai] Beijing Univ Chinese Med, Sch Acupuncture & Tuina, Meridians & acupoints teaching & Res Sect, Beijing 100029, Peoples R China.
   [Pang, Dandan] Acad Chinese Med Sci, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine
RP Cheng, K (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture & Tuina, Meridians & acupoints teaching & Res Sect, Beijing 100029, Peoples R China.; Pang, DD (corresponding author), Acad Chinese Med Sci, Beijing 100700, Peoples R China.
EM Pangdan000@126.com; kevin@chengs.cn
RI Shi, Tianyu/JAZ-0928-2023; yang, zhiwen/HTS-4958-2023
FU Fundamental Research Funds for the Central Universities Project: RNA
   Sequencing Technology Screening the Mechanism of Acupuncture on Pain in
   Chronic Pelvic Pain Syndrome Rats;  [2020-JYB-XJSJJ-018]
FX Supported by Fundamental Research Funds for the Central Universities
   Project: RNA Sequencing Technology Screening the Mechanism of
   Acupuncture on Pain in Chronic Pelvic Pain Syndrome Rats
   (2020-JYB-XJSJJ-018)
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NR 34
TC 7
Z9 8
U1 1
U2 21
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD DEC
PY 2022
VL 42
IS 6
BP 965
EP 971
DI 10.19852/j.cnki.jtcm.20220928.003
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6I3TM
UT WOS:000886050700001
PM 36378055
DA 2026-01-16
ER

PT J
AU Li, SS
   Huang, J
   Guo, Y
   Wang, JQ
   Lu, SS
   Wang, B
   Gong, YA
   Qin, SR
   Zhao, SH
   Wang, SJ
   Liu, YY
   Fang, YX
   Guo, YM
   Xu, ZF
   Ulloa, L
AF Li, Shanshan
   Huang, Jin
   Guo, Yi
   Wang, Jiaqi
   Lu, Shanshan
   Wang, Bin
   Gong, Yinan
   Qin, Siru
   Zhao, Suhong
   Wang, Shenjun
   Liu, Yangyang
   Fang, Yuxin
   Guo, Yongming
   Xu, Zhifang
   Ulloa, Luis
TI PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune
   Protection During Cisplatin Chemotherapy
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE neuromodulation; chemotherapy; immunosuppression; hematopoiesis;
   neurotoxic; electroacupuncture
ID CYCLASE-ACTIVATING POLYPEPTIDE; HEMATOPOIETIC STEM; ADENYLATE-CYCLASE;
   CELL-PROLIFERATION; PERIPHERAL NEUROPATHY; INDUCED NEUTROPENIA; VAGAL
   MODULATION; LUNG-CANCER; GROWTH; INSIGHTS
AB Platinum-based chemotherapy is an effective treatment used in multiple tumor treatments, but produces severe side effects including neurotoxicity, anemia, and immunosuppression, which limits its anti-tumor efficacy and increases the risk of infections. Electroacupuncture (EA) is often used to ameliorate these side effects, but its mechanism is unknown. Here, we report that EA on ST36 and SP6 prevents cisplatin-induced neurotoxicity and immunosuppression. EA induces neuroprotection, prevents pain-related neurotoxicity, preserves bone marrow (BM) hematopoiesis, and peripheral levels of leukocytes. EA activates sympathetic BM terminals to release pituitary adenylate cyclase activating polypeptide (PACAP). PACAP-receptor PAC1-antagonists abrogate the effects of EA, whereas PAC1-agonists mimic EA, prevent neurotoxicity, immunosuppression, and preserve BM hematopoiesis during cisplatin chemotherapy. Our results indicate that PAC1-agonists may provide therapeutic advantages during chemotherapy to treat patients with advanced neurotoxicity or neuropathies limiting EA efficacy.
C1 [Li, Shanshan; Huang, Jin; Guo, Yi; Wang, Jiaqi; Lu, Shanshan; Gong, Yinan; Qin, Siru; Zhao, Suhong; Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Guo, Yongming; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin, Peoples R China.
   [Guo, Yi] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin, Peoples R China.
   [Guo, Yi; Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Guo, Yongming; Xu, Zhifang] Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin, Peoples R China.
   [Wang, Bin] Tianjin Med Univ, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Canc Inst & Hosp, Tianjin, Peoples R China.
   [Wang, Shenjun; Liu, Yangyang; Fang, Yuxin; Guo, Yongming; Xu, Zhifang] Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, Tianjin, Peoples R China.
   [Ulloa, Luis] Duke Univ, Ctr Perioperat Organ Protect, Dept Anesthesiol, Durham, NC 27708 USA.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin Medical University; Tianjin
   University of Traditional Chinese Medicine; Duke University
RP Xu, ZF (corresponding author), Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin, Peoples R China.; Xu, ZF (corresponding author), Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin, Peoples R China.; Xu, ZF (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Moxibust & Tuina, Tianjin, Peoples R China.; Ulloa, L (corresponding author), Duke Univ, Ctr Perioperat Organ Protect, Dept Anesthesiol, Durham, NC 27708 USA.
EM xuzf1209@tjutcm.edu.cn; Luis.Ulloa@Duke.edu
RI Ulloa, Luis/AAE-8751-2019; Huang, Jin/IUO-0445-2023; Gong,
   Yinan/LWM-9133-2024; Xu, Zhifang/AAF-4798-2019
OI Ulloa, Luis/0000-0002-7702-7549; Xu, Zhifang/0000-0002-0576-163X
FU National Natural Science Foundation of China [81704146, 82030125,
   82074534]; Research Project of Tianjin Municipal Health Commission on
   Traditional Chinese Medicine and Integrative Medicine [2019140];
   Graduate Research Innovation Project of Tianjin University of
   Traditional Chinese Medicine [YJSKC-20201009, YJSKC20201029]; NIH
   [R01-GM114180]
FX This work was financially supported by the National Natural Science
   Foundation of China (grant numbers 81704146, 82030125, 82074534).
   Research Project of Tianjin Municipal Health Commission on Traditional
   Chinese Medicine and Integrative Medicine (grant number 2019140),
   Graduate Research Innovation Project of Tianjin University of
   Traditional Chinese Medicine (grant numbers YJSKC-20201009,
   YJSKC20201029), and LU are supported by the NIH R01-GM114180.
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NR 88
TC 10
Z9 12
U1 3
U2 42
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD SEP 6
PY 2021
VL 12
AR 714244
DI 10.3389/fimmu.2021.714244
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA UT9RN
UT WOS:000698445100001
PM 34552585
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jiang, L
   Deng, ZX
   Zhang, HC
   Li, Y
   Wang, TT
   Xie, W
AF Jiang, Li
   Deng, Zhaoxia
   Zhang, Hongcai
   Li, Yuan
   Wang, Tingting
   Xie, Wen
TI Acupoint for angina pectoris A protocol for systematic review and
   meta-analysis
SO MEDICINE
LA English
DT Review
DE acupoint therapies; angina pectoris; protocol; systematic review
ID ACUPUNCTURE
AB Introduction: Patients with angina pectoris (AP) often experience heavy psychological distress, especially anxiety and depression, which results in poorer quality of life, shorter survival time. Acupoint therapies, including massage, acupuncture, acupoints injection, acupressure, and moxibustion, showed clinical and long-lasting benefits for AP, but the efficiency of acupoint therapies was poorly evaluated. The current review is attempted to evaluate the efficacy and safety of the different acupoint-based therapies for AP. Methods and analysis: A literature search will be conducted in MEDLINE, EMBASE, Web of Science, Cochrane Library, Web of Science, PubMed, Science Direct, Wan Fang Data Knowledge Service Platform, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP database), and China National Knowledge Infrastructure (CNKI). Observational studies regarding the association between liver cancer and depression and anxiety written in English or Chinese will be included. Study inclusion, data extraction, and quality assessment will be performed independently by 2 reviewers. We will use RevMan V.5.0 and STATA V.12.0 software for statistical analysis. The I-2 test will be used to identify the extent of heterogeneity. Publication bias will be assessed by generating a funnel plot and performing the Begg and Egger test. The quality of the systematic review will be evaluated using the Measurement Tool to Assess Systematic Reviews (AMSTAR) and Grading of Recommendations Assessment Development and Evaluation (GRADE) criteria. With the permitted numeric data, we will carry out a meta-analysis. Results: This study will provide a high-quality synthesis of pain VAS and functional disability or the quality of life, the success treatment rate, the recurrent rate and the complications rate to assess the effectiveness and safety of acupoint for AP patients. This systematic review will provide evidence to judge whether acupoint is an effective intervention for patients with AP. Conclusion: This systematic review and meta-analysis will provide evidence to judge whether acupoint is an effective intervention for patients with AP and provide evidence for designing early targeted interventions for high-risk survivors that can attenuate negative reactions. PROSPERO registration number: 10.17605/OSF.IO/VNXWE.
C1 [Jiang, Li; Deng, Zhaoxia; Li, Yuan; Wang, Tingting; Xie, Wen] Hosp Chengdu Univ Tradit Chinese Med, 39 Shi Er Qiao Rd, Chengdu 610072, Sichuan, Peoples R China.
   [Zhang, Hongcai] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Xie, W (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, 39 Shi Er Qiao Rd, Chengdu 610072, Sichuan, Peoples R China.
EM 1131649799@qq.com
RI wang, tingting/IYJ-7765-2023
FU Chengdu University of Traditional Chinese Medicine Science and
   Technology Development Fund [ZRYB201014]
FX This work is supported by the Chengdu University of Traditional Chinese
   Medicine Science and Technology Development Fund (Grant numbers
   ZRYB201014).
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NR 9
TC 1
Z9 2
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 22
PY 2021
VL 100
IS 3
AR e24080
DI 10.1097/MD.0000000000024080
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6FV
UT WOS:000612835100092
PM 33546012
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chen, HY
   Li, SG
   Cho, WCS
   Zhang, ZJ
AF Chen, Hai-Yong
   Li, Shi-Guang
   Cho, William C. S.
   Zhang, Zhang-Jin
TI The role of acupoint stimulation as an adjunct therapy for lung cancer:
   a systematic review and meta-analysis
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
DE Acupuncture; Chinese medicine; Lung cancer; Systematic review;
   Meta-analysis
ID ACUPUNCTURE TREATMENT; ALTERNATIVE MEDICINE; INTERFERON-GAMMA;
   CELL-ACTIVITY; COMPLEMENTARY; INTERLEUKIN-2; ENHANCEMENT; CARCINOMA;
   EFFICACY; TH17
AB Background: Lung cancer is the leading cause of death in cancer patients. Clinical studies showed that a variety of acupoint stimulations have been extensively used for lung cancer patients, including needle insertion, injection with herbal extraction, plaster application, and moxibustion. However, the role of acupoint stimulation in lung cancer treatment was not fully reviewed.
   Methods: In the present study, we conducted a systematic review and meta-analysis on the role of acupoint stimulation in lung cancer treatment by electronic and manual searching in seven databases, including Ovid (Ovid MEDLINE, AMED, CAB Abstracts, EMBASE), EBSCOhost research databases (Academic Search premier, MEDLINE, CIHAHL Plus), PreQuest (British Nursing Index, ProQuest Medical Library, ProQuest Dissertations & Theses A&I, PsycINFO), and ISI web of knowledge (Web of Science, BIOSIS Citation Index, Biological Abstracts, Chinese Science Citation Database), CNKI, Wanfang Data, and CQVIP.
   Results: Our study showed that acupoint stimulation has strong immunomodulatory effect for lung cancer patients as demonstrated by the significant increase of IL-2, T cell subtypes (CD3+ and CD4+, but not CD8+ cells), and natural killer cells. Further analysis revealed that acupoint stimulation remarkably alleviates the conventional therapy-induced bone marrow suppression (hemoglobin, platelet, and WBC reduction) in lung cancer patients, as well as decreases nausea and vomiting. The pooled studies also showed that acupoint stimulation can improve Karnofsky performance status, immediate tumor response, quality of life (EORCT-QLQ-C30), and pain control of cancer patients.
   Conclusions: Acupoint stimulation is found to be effective in lung cancer treatment, further confirmatory evaluation via large scale randomized trials is warranted.
C1 [Chen, Hai-Yong; Zhang, Zhang-Jin] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China.
   [Li, Shi-Guang] Shenzhen Hosp TCM, Dept Oncol & Hematol, Shenzhen, Guangdong, Peoples R China.
   [Cho, William C. S.] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Cho, WCS (corresponding author), Queen Elizabeth Hosp, Dept Clin Oncol, 30 Gascoigne Rd, Kowloon, Hong Kong, Peoples R China.
EM williamcscho@gmail.com; Zhangzj@hku.hk
RI CHEN, Haiyong/G-6787-2014; ZHANG, ZHANG-JIN/ORK-0709-2025; Cho,
   William/H-7429-2019
OI CHEN, Haiyong/0000-0002-4889-2752; 
CR [Anonymous], COCHRANE DATABASE SY
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NR 65
TC 43
Z9 53
U1 3
U2 53
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD DEC 17
PY 2013
VL 13
AR 362
DI 10.1186/1472-6882-13-362
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 284XG
UT WOS:000329354800001
PM 24344728
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tan, J
   Feng, Y
   Liu, H
   Zhou, YH
   Cai, JQ
   Jiang, YY
   Li, PY
   Gu, LB
   Song, ZH
AF Tan, Jing
   Feng, Yong
   Liu, Hui
   Zhou, Yihu
   Cai, Jiaqin
   Jiang, Yueyi
   Li, Pengyi
   Gu, Lianbing
   Song, Zhenghuan
TI Effect of press needle stimulation on postoperative pulmonary
   complications in video-assisted thoracoscopic surgery patients: a
   randomized controlled trial
SO ANNALS OF MEDICINE
LA English
DT Article
DE Press needle; video-assisted thoracoscopic surgery; postoperative
   pulmonary complications; postoperative pain control
ID INFLAMMATORY RESPONSES; ACUPUNCTURE TREATMENT; ACUPOINT STIMULATION;
   THORACIC-SURGERY; OXIDATIVE STRESS; LUNG INJURY; RATS;
   ELECTROACUPUNCTURE; LOBECTOMY; VENTILATION
AB BackgroundPatients undergoing high-risk surgical procedures frequently experience postoperative pulmonary complications (PPCs) that impact outcomes. Acupuncture has demonstrated potential benefits during surgery. Press needle stimulation is increasingly recognized as an alternative to conventional techniques. We aimed to evaluate the effect of press needle stimulation on PPCs in patients with lung cancer undergoing video-assisted thoracoscopic surgery.MethodsEighty-seven patients undergoing video-assisted thoracoscopic surgery were randomized into press needle (n = 48) or sham needle (n = 39) groups. The press needle group underwent bilateral stimulation of acupoints LU9 (Taiyuan), RN17 (Danzhong), LU6 (Kongzui), and BL13 (Feishu) before anesthesia and during surgery. The sham group received a placebo stimulation. The primary endpoint was the incidence of PPCs within seven days post-surgery. The secondary endpoints included cytokine levels, intraoperative respiratory mechanics, postoperative pain score, analgesic consumption, and related complications.ResultsPress needle acupoint stimulation was associated with a significantly lower incidence of PPCs than the sham needle group. Perioperative data, tachycardia, cough, postoperative nausea, vomiting, and most inflammatory markers exhibited no significant differences, except for lower hypoxia-inducible factor-1 alpha levels in the press needle group. Hemodynamic and blood gas analyses indicated no significant cardiovascular or respiratory differences between groups. The press needle group exhibited reduced patient-controlled analgesia (PCA) pump utilization and lower total PCA usage, indicating improved pain management.ConclusionThis study indicates that press needle stimulation lowers PPC incidence and improves postoperative analgesia in patients with lung cancer undergoing video-assisted thoracoscopic lobectomy.
C1 [Tan, Jing; Liu, Hui; Li, Pengyi; Gu, Lianbing; Song, Zhenghuan] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Anesthesiol, Nanjing 21009, Peoples R China.
   [Tan, Jing; Liu, Hui; Cai, Jiaqin; Li, Pengyi; Gu, Lianbing; Song, Zhenghuan] Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 21009, Peoples R China.
   [Tan, Jing; Liu, Hui; Cai, Jiaqin; Li, Pengyi; Gu, Lianbing; Song, Zhenghuan] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 21009, Peoples R China.
   [Tan, Jing; Cai, Jiaqin; Gu, Lianbing] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Radiol, Nanjing, Peoples R China.
   [Feng, Yong] Nanjing Med Univ, Nanjing, Peoples R China.
   [Zhou, Yihu; Jiang, Yueyi] Xuzhou Med Univ, Xuzhou, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University; Nanjing Medical University; Nanjing Medical University;
   Xuzhou Medical University
RP Gu, LB; Song, ZH (corresponding author), Nanjing Med Univ, Jiangsu Canc Hosp, Dept Anesthesiol, Nanjing 21009, Peoples R China.; Gu, LB; Song, ZH (corresponding author), Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 21009, Peoples R China.; Gu, LB; Song, ZH (corresponding author), Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 21009, Peoples R China.
EM 13951947684@163.com; songzhenghuan@njmu.edu.cn
FU Jiangsu Province Traditional Chinese Medicine Science and Technology
   Development Plan Project [YB201986]
FX This work was supported by Jiangsu Province Traditional Chinese Medicine
   Science and Technology Development Plan Project (Project No. YB201986).
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NR 56
TC 1
Z9 1
U1 3
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2025
VL 57
IS 1
AR 2560684
DI 10.1080/07853890.2025.2560684
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7JO2P
UT WOS:001572545900001
PM 40953233
OA Green Submitted, Green Accepted, gold
DA 2026-01-16
ER

PT J
AU Zhao, ZN
   Li, JW
   Wen, JM
   He, YY
   Sun, ZL
AF Zhao, Zhenni
   Li, Jiawei
   Wen, Jiamin
   He, Yanyan
   Sun, Zhiling
TI Effect of Moxibustion on Inflammatory Cytokines for Low Back Pain: A
   Systematic Review, Meta-Analysis and Meta-Regression
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Review
DE low back pain; moxibustion; cytokines; tumor necrosis factors;
   interleukins
ID DISC DEGENERATION; EXPRESSION
AB Background and Objective: Moxibustion is effective for low back pain (LBP), and inflammatory cytokines may play an important role in the mechanism of moxibustion treatment. The purpose of this meta-analysis was to explore the mechanism of moxibustion in LBP in terms of inflammatory cytokines.
   Methods: We searched China National Knowledge Infrastructure, Wanfang database, Cochrane Central Register of Controlled Trials, Ovid MEDLINE, Embase, PubMed, and Web of Science to identify eligible randomized controlled trials (RCTs). There was no restriction on the publication date.
   Results: Thirty RCTs measuring interleukin (IL-) 1, IL-1 beta, IL-6, IL-12, IL-17, IL-23, and tumor necrosis factor (TNF-) alpha were included in this meta-analysis. Compared to controls: single moxibustion could effectively decrease levels IL-6 and IL-23 (SMD, -0.71, 95% CI: -1.25 to -0.17, p = 0.01; SMD, -1.61, 95% CI: -2.20 to -1.03, p < 0.01, respectively); combined moxibustion had significant effects on IL-1, IL-1 beta, IL-6, IL-12, IL-17, and TNF-alpha (p < 0.05). Overall, for LBP, single or combined moxibustion could effectively down-regulate levels of pro-inflammatory cytokines (p = 0.007 and p < 0.00001, respectively). For safety of moxibustion, the incidence rate of side effects was similar to that of controls (RD, -0.01, 95% CI: -0.02 to 0.01, p = 0.59). Sensitivity analysis showed that the pooled estimates were robust, and publication bias analysis showed there was a significant small study effect (Egger's test p = 0.0000). High statistical heterogeneity existed between included RCTs, meta-regression showed there was no potential factor explaining the source of heterogeneity.
   Conclusion: For LBP, moxibustion can effectively decrease levels of IL-1, IL-1 beta, IL-6, IL-12, IL-17, IL-23, and TNF-alpha to achieve analgesia. Because the side effects of moxibustion are transient, it is relatively safe for clinical use. However, based on high heterogeneity in this meta-analysis, rigorously designed RCTs are required to further confirm the results in this review.
C1 [Zhao, Zhenni] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Nursing Dept, Hangzhou, Zhejiang, Peoples R China.
   [Li, Jiawei; Wen, Jiamin; He, Yanyan; Sun, Zhiling] Nanjing Univ Chinese Med, Sch Nursing, Nanjing, Peoples R China.
C3 Zhejiang University; Nanjing University of Chinese Medicine
RP Sun, ZL (corresponding author), Nanjing Univ Chinese Med, Sch Nursing, 138 Xian Lin Rd, Nanjing, Peoples R China.
EM szl@njucm.edu.cn
RI Sun, Zhi-ling/HZI-1723-2023
OI Sun, Zhi-ling/0000-0002-5863-4802
FU Postgraduate Research & Practice Innovation Program of Jiangsu Province
   [SJCX23_0735]
FX This work was supported by the Postgraduate Research & Practice
   Innovation Program of Jiangsu Province (No. SJCX23_0735).
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NR 63
TC 9
Z9 10
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2023
VL 19
BP 811
EP 827
DI 10.2147/TCRM.S429469
PG 17
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA IV1E9
UT WOS:001169012800001
PM 37873037
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Su, CF
AF Su, Ching-Feng
TI Home care with acupuncture increased the quality of life in a patient
   with advanced cancer with neuropathic pain induced by bone metastasis: a
   case report
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Acupuncture; Case report; Cancer; Neuropathic pain; Quality of life;
   Hospice care; Palliative care
ID PERIPHERAL NEUROPATHY; ETIOLOGY; BURDEN; IMPACT
AB A 66-year-old female patient was diagnosed with hepatocellular carcinoma accompanied by neuropathic pain induced by a metastatic tumor that compromised root and spinal canal. Although her pain was relieved following medical treatment, breakthrough pain occurring 1-2 times a day was still distressing. Neuropathic pain in her right lower limb caused discomfort and irritability and decreased her quality of life. We had limited options to adjust her prescription drug regime, due to the side effect of these drugs. Although acupuncture therapy was only performed at her home once a week, the efficacy was outstanding. The patient did not report any further instances of breakthrough pain, and she did not require additional bolus morphine. She could comfortably live in her familiar surroundings with her family and did not require any emergency room visits or admission into the hospital during the last month of her life. She had excellent quality of life in the terminal period of her life, and could even participate in a family function during this time. The present case report suggests that acupuncture may have a role in treating neuropathic pain induced by bone metastasis in patients with advanced cancer across clinical and in-home settings. (C) 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
C1 [Su, Ching-Feng] Pingtung Christian Hosp, Dept Family Med, Pingtung 900, Pingtung County, Taiwan.
RP Su, CF (corresponding author), Pingtung Christian Hosp, Dept Family Med, Pingtung 900, Pingtung County, Taiwan.
EM 04836@ptch.org.tw
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NR 22
TC 5
Z9 9
U1 1
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAY
PY 2018
VL 16
IS 3
BP 208
EP 210
DI 10.1016/j.joim.2018.04.003
PG 3
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GG4LZ
UT WOS:000432669500010
PM 29691187
DA 2026-01-16
ER

PT J
AU Maurer, J
   Friedemann, T
   Chen, YL
   Ambrosini, F
   Knipper, S
   Maurer, T
   Heinzer, H
   Thederan, I
   Schroeder, S
AF Maurer, Jean
   Friedemann, Thomas
   Chen, Yuelai
   Ambrosini, Francesca
   Knipper, Sophie
   Maurer, Tobias
   Heinzer, Hans
   Thederan, Imke
   Schroeder, Sven
TI A randomized controlled study on acupuncture for peri-operative pain
   after open radical prostatectomy
SO BJU INTERNATIONAL
LA English
DT Article
DE acupuncture; peri-operative pain; open radical prostatectomy; press tack
   needle; pain reduction; prostate cancer
ID MAST-CELLS
AB Objectives: To evaluate the advantages of adding acupuncture to standard postoperative pain management for open radical prostatectomy (RP). Materials and methods: A randomized controlled trial (1:1:1) comparing routine postoperative analgesic care (control [CON]) vs the addition of press tack needle acupuncture (ACU) or press tack placebo acupressure (SHAM) for pain management after open RP was performed. A total of 126 patients were enrolled between February 2020 and April 2021. After open RP, the CON group received standard postoperative analgesia, the ACU group received long-term acupuncture with press tacks at specific points (P-6, Shenmen and SP-6) along with standard analgesia, and the SHAM group received placebo press tacks at the same acupuncture points alongside standard analgesia. The primary endpoint was postoperative pain measured on a numeric rating scale, the NRS-11, calculated as the area under the curve. The cumulative use of routine postoperative analgesics, time to first defaecation, and quality of life were analysed using the Kruskal-Wallis rank sum test, Fisher's exact test, and Pearson's chi-squared test. Results: The ACU group reported significantly less postoperative pain compared to the SHAM (P = 0.007) and CON groups (P = 0.02). There were no significant difference in median (interquartile range) cumulative pain medication usage, time to first defaecation (CON: 37 [33, 44] h; SHAM: 37 [33, 42] h; ACU: 37 [33, 41] h; P > 0.9), or health status at discharge (EuroQol five-dimension, five-level general health assessment questionnaire: CON: 70 [65-83]; SHAM: 70 [60-80]; ACU: 70 [50-80]). Conclusion: Incorporating acupuncture into postoperative pain management can improve patient postoperative outcomes.
C1 [Maurer, Jean; Ambrosini, Francesca; Knipper, Sophie; Maurer, Tobias; Heinzer, Hans; Thederan, Imke] Univ Hosp Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Martinistr 52, D-20246 Hamburg, Germany.
   [Maurer, Tobias] Univ Hosp Hamburg Eppendorf, Dept Urol, Hamburg, Germany.
   [Friedemann, Thomas; Schroeder, Sven] Univ Hosp Eppendorf, HanseMerkur Ctr Tradit Chinese Med, Hamburg, Germany.
   [Chen, Yuelai] Shanghai Univ TCM, Longhua Hosp, Shanghai, Peoples R China.
   [Ambrosini, Francesca] IRCCS Osped Policlin San Martino, Genoa, Italy.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   Shanghai University of Traditional Chinese Medicine; University of
   Genoa; IRCCS AOU San Martino IST
RP Maurer, J (corresponding author), Univ Hosp Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Martinistr 52, D-20246 Hamburg, Germany.
EM drjean.maurer@gmail.com
RI Ambrosini, Francesca/ABD-8954-2021; Friedemann, Thomas/GYQ-9261-2022
OI Schroeder, Sven/0000-0002-8798-9602; 
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NR 30
TC 10
Z9 10
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD JUN
PY 2024
VL 133
IS 6
BP 725
EP 732
DI 10.1111/bju.16288
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA QO0J6
UT WOS:001221693200021
PM 38316611
DA 2026-01-16
ER

PT J
AU Mahfudh, SS
AF Mahfudh, Salma Said
TI Nurse's Role in Controlling Cancer Pain
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Article
DE nurse's; cancer pain; management
AB Nurses spend more time with patients than any other member of the healthcare team. They play a critical, active and very important part in controlling cancer patients' pain and alleviating suffering. In controlling cancer pain the nurse needs to understand the psychological state of the cancer patient, cancer pain, cancer pain treatment, deleterious effects of unrelieved cancer pain and patient's socio cultural background. She needs to understand that there are two types of pain, nociceptive and neuropathic pains and that 80% of the cancer patients in pain could have 2 or more than 4 different pains at the same time. Nurses' role in controlling cancer pain include believing the patient, assessing pain, identifying the root of the problem, planning the care, administering medication, evaluating effectiveness, ensuring good pain control and individualizing treatment. It also includes nursing interventions such as giving tender nursing care, preventing pain, educating, advocating, communicating, comforting, supporting, and counseling the patient. The nurse must use both pharmacological and non pharmacological treatments to individualize treatment, know all the drugs that are used for the treatment of Cancer Pain, how these drugs relieve pain and what their side effects are. She must use the WHO guidelines to treat pain and must choose the right drug, right dose, given at the right times, with the right intervals and to the right patient. She must evaluate effectiveness of treatment, give PRN doses for breakthrough pain and recommend for specific changes. The role of the nurse is to anticipate the patient's pain needs, advocate for the patient for what feels appropriate for him within his cultural context and incorporate the patient's belief. The nurse can physically relieve pain by promoting comfort, support painful area, gentleness in handling the patient and use nursing treatments. The nurse can recommend physiotherapy, (TENS)/Acupuncture, Occupational therapy, spiritual support, social worker, psychologist, and psychiatrist to address different types of pain. She must relieve both pain and other symptoms. and ensure that the patient has good sleep. She must show kindness, compassion and empathize with him. Each patient is unique the process of controlling cancer pain develops differently each time. The nurse's role is challenging, she must demonstrate that she is not only clinically proficient but culturally competent. She has to use creative assessment skills, clinical judgment, psychological support, advocacy and good communication skills in such a way that the contribution of drugs, nursing care, nursing and other non pharmacological treatments are maximized to the patient's benefit. When evaluating the overall care the nurse must find out what is the total effect of all approaches taken to relieve pain. Nurses can make a difference between a patient who suffers until the last breath of his/her life and a patient who is comfortable and dies pain free and in dignity.
C1 Obstet & Pain Management Certificates, Mina Al Fahal, Oman.
RP Mahfudh, SS (corresponding author), Obstet & Pain Management Certificates, POB 9,Code 116, Mina Al Fahal, Oman.
EM ssmahfudh@hotmail.com
NR 0
TC 6
Z9 10
U1 1
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD OCT
PY 2011
VL 33
SU 2
BP S146
EP S148
DI 10.1097/MPH.0b013e318230dfd8
PG 3
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA 835ED
UT WOS:000296016700015
PM 21952573
DA 2026-01-16
ER

PT J
AU Henss, H
   Münstedt, K
   Jückstock, J
   Reinert, E
   Hübner, J
AF Henss, H.
   Muenstedt, K.
   Jueckstock, J.
   Reinert, E.
   Huebner, J.
TI Supportive measures of complementary medicine
SO ONKOLOGE
LA German
DT Article
DE Supportive care; Complementary therapy; Acupuncture; Phytotherapy;
   Mind-body techniques
ID CHEMOTHERAPY-INDUCED NAUSEA; CONTROLLED CLINICAL-TRIAL;
   IRRITABLE-BOWEL-SYNDROME; BREAST-CANCER PATIENTS; ALTERNATIVE MEDICINE;
   DOUBLE-BLIND; ANTICIPATORY NAUSEA; ACUPUNCTURE; PREVENTION; PAIN
AB When controlling symptoms in malignant diseases, complementary therapies can make important contributions. This is demonstrated in several important and/or frequent symptoms in cancer patients. Complementary therapies should supplement but not replace established treatments and can be useful, especially where no other established procedures are available. Treatments involve herbal applications as well as acupuncture and so-called mind-body techniques. As information on tumor patients is sometimes insufficient, extrapolation from experiences with other diseases may be helpful, at least as far as side-effects are concerned. Possible drug interactions must be kept in mind especially with herbal treatments.
C1 [Henss, H.; Reinert, E.] Univ Klinikum Freiburg, Tumorzentrum Ludwig Heilmeyer CCCF, D-79106 Freiburg, Germany.
   Klinikum Justus Liebig Univ Giessen, Geburtshilfe & Gynakol Abt, Giessen, Germany.
   [Jueckstock, J.] Klinikum Ludwig Maximilians Univ Munchen, Frauenklin Innenstadt, Munich, Germany.
   [Huebner, J.] UCT Univ Klinikum Frankfurt, Palliat Med & Komplementare Onkol, Frankfurt, Germany.
C3 University of Freiburg; Justus Liebig University Giessen; University of
   Munich
RP Henss, H (corresponding author), Univ Klinikum Freiburg, Tumorzentrum Ludwig Heilmeyer CCCF, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM hartmut.henss@uniklinik-freiburg.de
RI HÃ¼bner, Jutta/AAY-5396-2020; Jueckstock, Julia/IRZ-7785-2023
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NR 45
TC 1
Z9 1
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0947-8965
EI 1433-0415
J9 ONKOLOGE
JI Onkologe
PD AUG
PY 2010
VL 16
IS 8
BP 795
EP 801
DI 10.1007/s00761-010-1819-5
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 643IO
UT WOS:000281289000009
DA 2026-01-16
ER

PT J
AU Han, ZZ
   Zhang, Y
   Wang, PQ
   Tang, QL
   Zhang, K
AF Han, Zhenzhen
   Zhang, Yang
   Wang, Pengqian
   Tang, Qilin
   Zhang, Kai
TI Is acupuncture effective in the treatment of COVID-19 related symptoms?
   Based on bioinformatics/network topology strategy
SO BRIEFINGS IN BIOINFORMATICS
LA English
DT Article
DE acupuncture; interventions; COVID-19; bioinformatics; network topology
ID BETA-ENDORPHIN; ELECTROACUPUNCTURE; HYPOTHALAMUS; CANCER; RATS; PAIN;
   METAANALYSIS; EXPRESSION; MECHANISM; THERAPY
AB Acupuncture is an important part of Chinese medicine that has been widely used in the treatment of inflammatory diseases. During the coronavirus disease 2019 (COVID-19) epidemic, acupuncture has been used as a complementary treatment for COVID-19 in China. However, the underlying mechanism of acupuncture treatment of COVID-19 remains unclear. Based on bioinformatics/topology, this paper systematically revealed the multi-target mechanisms of acupuncture therapy for COVID-19 through text mining, bioinformatics, network topology, etc. TWo active compounds produced after acupuncture and 180 protein targets were identified. A total of 522 Gene Ontology terms related to acupuncture for COVID-19 were identified, and 61 pathways were screened based on the Kyoto Encyclopedia of Genes and Genomes. Our findings suggested that acupuncture treatment of COVID-19 was associated with suppression of inflammatory stress, improving immunity and regulating nervous system function, including activation of neuroactive ligand-receptor interaction, calcium signaling pathway, cancer pathway, viral carcinogenesis, Staphylococcus aureus infection, etc. The study also found that acupuncture may have additional benefits for COVID-19 patients with cancer, cardiovascular disease and obesity. Our study revealed for the first time the multiple synergistic mechanisms of acupuncture on COVID-19. Acupuncture may play an active role in the treatment of COVID-19 and deserves further promotion and application. These results may help to solve this pressing problem currently facing the world.
C1 [Wang, Pengqian] China Acad Chinese Med Sci, Inst Chinese Mat Med, 16 Dongzhimennei, Beijing 100700, Peoples R China.
   [Han, Zhenzhen] Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin, Peoples R China.
   [Zhang, Yang] Tianjin Hosp Integrated Tradit Chinese & Western, Tianjin, Peoples R China.
   [Tang, Qilin] Hebei Univ Chinese Med, Shijiazhuang, Hebei, Peoples R China.
   [Zhang, Kai] Tianjin Gong An Hosp, Tianjin, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS; Hebei University of Chinese Medicine
RP Zhang, K (corresponding author), Tianjin Gong An Hosp, Dept Acupuncture & Moxibust, 78 Nanjing Rd, Tianjin 300042, Peoples R China.; Tang, QL (corresponding author), Hebei Univ Chinese Med, Sch Basic Med Sci, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China.; Wang, PQ (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, 16 Dongzhimennei, Beijing 100700, Peoples R China.
EM pengqian.wang@163.com; tqilin123@126.com; coolzhangkai@163.com
RI Zhang, Kai/B-1769-2019
CR [Anonymous], 2020, Covid-19 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins
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NR 90
TC 40
Z9 47
U1 3
U2 50
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1467-5463
EI 1477-4054
J9 BRIEF BIOINFORM
JI Brief. Bioinform.
PD SEP
PY 2021
VL 22
IS 5
AR bbab110
DI 10.1093/bib/bbab110
EA APR 2021
PG 11
WC Biochemical Research Methods; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA WK0YX
UT WOS:000709461800135
PM 33866350
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU You, EH
AF You, Eunhea
TI Nontraditional and Home-Based Self-management Interventions in Cancer
   Patients With Pain A Mixed-Method Systematic Review
SO HOLISTIC NURSING PRACTICE
LA English
DT Article
DE cancer patients; nontraditional and home-based intervention;
   self-management
ID AURICULAR POINT ACUPRESSURE; RANDOMIZED CONTROLLED-TRIAL; CHRONIC CARE
   MODEL; ONCOLOGY OUTPATIENTS; ANALGESIC TREATMENT; CLINICAL-TRIAL; LIFE;
   EDUCATION; EFFICACY; FATIGUE
AB One or 2 decades ago, oncologists focused on only cancer treatments or acute care related to cancer. Since cancer care is considered as long-term cares, cancer patients require self-management (SM) ability or skill to manage their symptoms and daily cares. This mixed-method review is to evaluate quantitative and qualitative studies, which were conducted using non-traditional SM interventions for cancer pain based. This review also explores the process of SM in the chronic care model (CCM). PubMed, CINAHL, Scopus, and Wiley were used from 2011 to 2018. A total of 16 quantitative and 2 qualitative studies were included for this review. All interventions are divided into 3 types, which are educational and/or counseling programs, complementary and alternative medicine (CAM) therapy, and exercise. Ten of the included 16 studies were statistically significant on pain management: 3 CAM studies (100%), 1 exercise study (100%), and 6 of the 12 educational and/or counseling studies (50%). The CAM and exercise were statistically effective in improving cancer pain in the review. However, uncertainty remains regarding the strength of the evidence, due to the small number of studies included and lack of consistent methodologies. The application (5A) of SM support may help cancer patients to manage their pain.
C1 [You, Eunhea] Rutgers State Univ, Dept Nursing, 180 Univ Ave, Newark, NJ 07102 USA.
C3 Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick
RP You, EH (corresponding author), Rutgers State Univ, Dept Nursing, 180 Univ Ave, Newark, NJ 07102 USA.
EM ey100@sn.rutgers.edu
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NR 43
TC 5
Z9 5
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0887-9311
EI 1550-5138
J9 HOLIST NURS PRACT
JI Holist. Nurs. Pract.
PD MAY-JUN
PY 2020
VL 34
IS 3
BP 138
EP 149
DI 10.1097/HNP.0000000000000380
PG 12
WC Integrative & Complementary Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine; Nursing
GA LL1VX
UT WOS:000531344200002
PM 32282489
DA 2026-01-16
ER

PT J
AU Roscoe, JA
   O'Neill, M
   Jean-Pierre, P
   Heckler, CE
   Kaptchuk, TJ
   Bushunow, P
   Shayne, M
   Huston, A
   Qazi, R
   Smith, B
AF Roscoe, Joseph A.
   O'Neill, Michael
   Jean-Pierre, Pascal
   Heckler, Charles E.
   Kaptchuk, Ted J.
   Bushunow, Peter
   Shayne, Michelle
   Huston, Alissa
   Qazi, Raman
   Smith, Brian
TI An Exploratory Study on the Effects of an Expectancy Manipulation on
   Chemotherapy-Related Nausea
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Acupressure bands; expectation; chemotherapy; nausea; suggestion;
   targeted information
ID CLINICAL ONCOLOGY PROGRAM; CANCER-CENTER COMMUNITY; RANDOMIZED
   CONTROLLED-TRIAL; PLACEBO; EXPECTATIONS; ACUPRESSURE; RELAXATION;
   PREDICTOR; HYPNOSIS; CHILDREN
AB Context. Previous research has shown that the effectiveness of acupressure bands in reducing chemotherapy-related nausea is related to patients' expectations of efficacy.
   Objective. To test whether an informational manipulation designed to increase expectation of efficacy regarding acupressure bands would enhance their effectiveness.
   Methods. We conducted an exploratory, four-arm, randomized clinical trial in breast cancer patients about to begin chemotherapy. All patients received acupressure bands and a relaxation CD. This report focuses on Arm 1(expectancyneutral informational handout and CD) compared with Arm 4 (expectancy-enhancing handout and CD). Randomization was stratified according to the patient's level of certainty that she would have treatment-induced nausea (two levels: high and low). Experience of nausea and use of antiemetics were assessed with a five-day diary.
   Results. Our expectancy-enhancing manipulation resulted in improved control of nausea in the 26 patients with high nausea expectancies but lessened control of nausea in 27 patients having low nausea expectancies. This interaction effect (between expected nausea and intervention effectiveness) approached statistical significance for our analysis of average nausea (P=0.084) and reached statistical significance for our analysis of peak nausea (P=0.030). Patients receiving the expectancy-enhancing manipulation took fewer antiemetic pills outside the clinic (mean(enhanced) = 12.6; mean(nentral) = 18.5, P=-0.003).
   Conclusion. This exploratory intervention reduced antiemetic use overall and also reduced nausea in patients who had high levels of expected nausea. Interestingly, it increased nausea in patients who had low expectancies for nausea. Confirmatory research is warranted. J Pain Symptom Manage 2010;40:379-390. (C) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
C1 [Roscoe, Joseph A.; O'Neill, Michael; Jean-Pierre, Pascal; Heckler, Charles E.; Shayne, Michelle; Huston, Alissa; Qazi, Raman; Smith, Brian] Univ Rochester, James P Wilmot Canc Ctr, Rochester, NY 14642 USA.
   [Kaptchuk, Ted J.] Harvard Univ, Sch Med, Boston, MA USA.
   [Bushunow, Peter] Rochester Gen Hosp, Ctr Canc, Rochester, NY 14621 USA.
C3 University of Rochester; Harvard University; Harvard Medical School;
   Rochester General Hospital
RP Roscoe, JA (corresponding author), Univ Rochester, James P Wilmot Canc Ctr, 601 Elmwood Ave,Box 704, Rochester, NY 14642 USA.
EM Joseph_Roscoe@urmc.rochester.edu
FU National Cancer Institute [1R21CA118883, 1R25-CA102618-01A1]
FX This work was supported by Grants 1R21CA118883 and 1R25-CA102618-01A1
   from the National Cancer Institute.
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NR 47
TC 33
Z9 37
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD SEP
PY 2010
VL 40
IS 3
BP 379
EP 390
DI 10.1016/j.jpainsymman.2009.12.024
PG 12
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 652TJ
UT WOS:000282032500005
PM 20579837
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Duzova, US
   Can, G
   Duzova, M
   Basaran, H
   Yavas, C
AF Duzova, Ulku Saygili
   Can, Gulbeyaz
   Duzova, Mursel
   Basaran, Hamit
   Yavas, Cagdas
TI The effect of acupressure on anxiety, depression, pain, and vital signs
   in gynecological cancer patients receiving brachytherapy: A randomized
   controlled study
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Acupressure; Anxiety; Brachytherapy; Depression; Gynecological cancer;
   Pain
ID CHEMOTHERAPY
AB Purpose: This study aimed to evaluate the effects of acupressure on pain, anxiety, depression, and physiological parameters in women undergoing brachytherapy for gynecological cancer. Methods: The research was conducted between December 2023 and September 2024 using a randomized controlled design. All patients receiving brachytherapy were randomly assigned to the acupressure group (n = 40) or the control group (n = 40). In addition to standard clinical care, the acupressure group received manual acupressure for 30 min before each brachytherapy session at specific acupressure points (SP6, PC6, LI4, HT7, LV4). The data were collected using the Personal Information Form, Visual Analog Scale (VAS), State-Trait Anxiety Inventory (STAI-I), Hospital Anxiety and Depression Scale (HADS), and Vital Signs Form. Results: The groups were comparable in terms of sociodemographic and clinical characteristics (p > 0.05). Significant reductions were observed in anxiety, depression, and pain levels in the acupressure group at post-test compared to baseline and the control group (p < 0.001). Additionally, diastolic blood pressure and body temperature significantly decreased in the intervention group (p < 0.001), whereas no significant differences were found for pulse and respiratory rate (p > 0.05). Conclusion: The results obtained from this study suggest that acupressure may be a beneficial complementary method for reducing anxiety, depression, and pain, as well as contributing to the regulation of certain physiological parameters in patients undergoing brachytherapy. These findings indicate that acupressure could be considered an intervention that may be integrated into clinical practice to support psychological and physiological well-being.
C1 [Duzova, Ulku Saygili] Selcuk Univ, Fac Nursing, Konya, Turkiye.
   [Can, Gulbeyaz] Istanbul Univ Cerrahpasa, Florence Nightingale Nursing Fac, Istanbul, Turkiye.
   [Duzova, Mursel; Basaran, Hamit; Yavas, Cagdas] Selcuk Univ, Fac Med, Dept Radiat Oncol, Konya, Turkiye.
C3 Selcuk University; Istanbul University - Cerrahpasa; Selcuk University
RP Duzova, US (corresponding author), Selcuk Univ, Fac Nursing, Konya, Turkiye.
EM ulkusaygili@selcuk.edu.tr; gulbeyaz@istanbul.edu.tr;
   mursel_duzova@hotmail.com; drhbasaran@gmail.com; drcagdasyavas@gmail.com
RI Düzova, Mürsel/CAJ-3320-2022; SAYGILI DUZOVA, Ulku/F-3364-2019; Basaran,
   Hamit/AEH-7879-2022; Can, Gulbeyaz/Q-2079-2015
OI Düzova, Mürsel/0000-0003-1036-2593; SAYGILI DUZOVA,
   Ulku/0000-0001-8402-0022; Basaran, Hamit/0000-0002-2122-8720; 
CR Amsbaugh AK, 2016, J CLIN ANESTH, V35, P509, DOI 10.1016/j.jclinane.2016.08.025
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NR 32
TC 0
Z9 0
U1 4
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUL 18
PY 2025
VL 33
IS 8
AR 698
DI 10.1007/s00520-025-09754-6
PG 13
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 5BY6S
UT WOS:001532043600002
PM 40679634
DA 2026-01-16
ER

PT J
AU Zhang, JN
   Ren, YH
   Wu, WZ
   Yuan, Y
   Wang, JL
   Tang, Y
   Zhou, YQ
   Qiao, YZ
   Liu, BQ
AF Zhang, Junning
   Ren, Yuehan
   Wu, Weizhen
   Yuan, Yi
   Wang, Jiale
   Tang, Yi
   Zhou, Yunqiao
   Qiao, Yizhuo
   Liu, Baoqin
TI Fire needle therapy for the treatment of cancer pain: a protocol for the
   systematic review and meta-analysis
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE fire needle therapy; cancer pain; protocol; systematic review;
   complementary and alternative medicine; efficacy; safety
ID ACUPUNCTURE; ANALGESIA
AB Background: Cancer patients frequently suffer pain as one of their symptoms. It includes acute and chronic pain and is one of the most feared symptoms for patients. About one-third of adults actively undergoing cancer treatment suffer from pain related to their condition. Cancer pain control remains suboptimal due to a lack of assessment, knowledge, and access. Fire needle therapy, a traditional Chinese medicine, offers a potentially beneficial addition to current pain management approaches. This protocol outlines a systematic review and meta-analysis to compile evidence and examine the pain-relieving effects and safety of fire needle therapy for cancer patients. Methods and analysis: We will systematically search China National Knowledge Infrastructure (CNKI), Wanfang Database, China Biology Medicine disc (CBM), China Science and Technology Journal Database (CSTJ or VIP), PubMed, Web of Science, Embase, Cochrane Central Registry of Controlled Trials (CENTRAL), Chinese Clinical Trial Registry (Chictr), Opengrey, Worldcat, and Scopus from inception through July 2023. Random control trials (RCTs) include all types of cancer patients (age >= 18 years) complaining of pain. The primary outcome will be changes in pain intensity measured by Visual Analogue Scale (VAS), Numerical Rating Scale (NRS), Neuropathic Pain Scale (NPS), or Brief Pain Inventory (BPI). Secondary outcomes include quality of life (EORTC QLQ-C30 and GCQ), performance status (KPS), times of burst pain, treatment response rate, the dose reduction of analgesic drugs, and side effects rates. Utilizing the Cochrane risk bias measurement tool: Risk of Bias 2 (RoB 2), the trials' quality will be evaluated, and meta-analysis will be performed using RevMan software (version 5.4). Discussion: This systematic review will be the first comprehensive review of the literature to provide a meta-analysis of fire needle therapy for cancer pain, including only Random control trials (RCTs). For the sake of transparency and to avoid future duplication, the publication of this protocol offers a clear illustration of the procedures utilized in this evaluation. The results of our future studies may provide a new approach and theoretical basis for the treatment of cancer pain by medical oncology professionals.
C1 [Zhang, Junning; Ren, Yuehan; Wu, Weizhen; Yuan, Yi] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Zhang, Junning] China Japan Friendship Hosp, Dept Oncol Integrat Chinese & Western Med, Beijing, Peoples R China.
   [Wang, Jiale] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing, Peoples R China.
   [Tang, Yi; Zhou, Yunqiao] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China.
   [Qiao, Yizhuo] China Acad Chinese Med Sci, Dept Gynecol, Xiyuan Hosp, Beijing, Peoples R China.
   [Liu, Baoqin] China Japan Friendship Hosp, TCM Gynecol, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; China-Japan Friendship Hospital;
   Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; China Academy of Chinese Medical Sciences; Xiyuan Hospital,
   CACMS; China-Japan Friendship Hospital
RP Zhang, JN (corresponding author), Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.; Zhang, JN (corresponding author), China Japan Friendship Hosp, Dept Oncol Integrat Chinese & Western Med, Beijing, Peoples R China.; Liu, BQ (corresponding author), China Japan Friendship Hosp, TCM Gynecol, Beijing, Peoples R China.
EM junningzhang@foxmail.com; baoqinliu529@126.com
RI Yuan, Yi/AGX-6170-2022; Ren, Yuehan/ISS-8156-2023
OI Yuan, Yi/0000-0002-1864-5718; Ren, Yuehan/0009-0008-7225-2908
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
CR [Anonymous], 2010, Liaoning J Trad Chinese Med, DOI DOI 10.13192/J.LJTCM.2010.10.166.MIJP.061
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NR 54
TC 0
Z9 0
U1 4
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD SEP 15
PY 2024
VL 15
AR 1358859
DI 10.3389/fneur.2024.1358859
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H3D2V
UT WOS:001322268800001
PM 39346768
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU So, TH
   Chan, SK
   Lee, VHF
   Chen, BZ
   Kong, FM
   Lao, LX
AF So, T-H
   Chan, S-K
   Lee, V. H-F
   Chen, B-Z
   Kong, F-M
   Lao, L-X
TI Chinese Medicine in Cancer Treatment - How is it Practised in the East
   and the West?
SO CLINICAL ONCOLOGY
LA English
DT Article
DE Cancer management; Chinese medicine; herbal medicine; traditional
   Chinese medicine
ID CELL LUNG-CANCER; CHEMOTHERAPY-INDUCED NAUSEA; BREAST-CANCER;
   CONTROLLED-TRIAL; HOT FLASHES; ACUPUNCTURE; MULTICENTER; MANAGEMENT;
   FATIGUE; PAIN
AB Chinese medicine therapies in cancer treatment are very common in the East. Although it is usually classified as a form of complementary and alternative therapy in the West, Chinese medicine is an independent medical profession in Hong Kong and mainland China. It has a different perspective in understanding health and diseases compared with Western medicine. In oncology practice, whereas Western medicine focuses on direct tumour eradication by surgery, radiation therapy and systemic therapies, Chinese medicine focuses on restoring body balance and enhancing the body's defences (immunity), in addition to some cytotoxic herbal therapies. Most often patients, especially those in the East, receive both treatments. Chinese medicine is also commonly used to reduce side-effects from chemotherapy or radiation therapy, to aid recovery after an operation, to palliate symptoms and to address survivorship issues. However, this raises concerns of drug-herb interactions and toxicity in combination therapies. Commonly used Chinese medicine treatment modalities include acupuncture, moxibustion, diet therapy, prescribed Chinese medicine herbal decoction, single Chinese medicine herbs or supplements and tai chi. Although there is an increasing trend of Chinese medicine use in cancer patients in both the East and the West, the scientific evidence of safety and efficacy is often questioned by oncologists. This article reviews the current evidence in different Chinese medicine therapies in cancer management in both the East and the West. (C) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
C1 [So, T-H; Chan, S-K; Lee, V. H-F; Kong, F-M] Univ Hong Kong, Li Ka Shing Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Lee, V. H-F; Kong, F-M] Univ Hong Kong, Shenzhen Hosp, Clin Oncol Ctr, Shenzhen, Peoples R China.
   [Chen, B-Z] Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Hong Kong, Peoples R China.
   [Lao, L-X] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
   [Lao, L-X] Univ Hong Kong, Shenzhen Hosp, Dept Chinese Med, Shenzhen, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; Chinese University of
   Hong Kong; University of Hong Kong; University of Hong Kong
RP So, TH (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China.
EM sth495@hku.hk
RI Lee, Victor/I-3554-2015; Lao, Lixing/P-9107-2019; Chan,
   Sik/AAQ-2918-2021; So, Tsz-him/U-1240-2019
OI Lee, Victor/0000-0002-6283-978X; 
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NR 65
TC 71
Z9 77
U1 2
U2 101
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0936-6555
EI 1433-2981
J9 CLIN ONCOL-UK
JI Clin. Oncol.
PD AUG
PY 2019
VL 31
IS 8
SI SI
BP 578
EP 588
DI 10.1016/j.clon.2019.05.016
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA IG2EP
UT WOS:000473609300012
PM 31178347
OA Bronze
DA 2026-01-16
ER

PT J
AU Cheung, DST
   Yeung, WF
   Chau, PH
   Lam, TC
   Yang, MX
   Lai, K
   Ip, CY
   Lao, LX
   Lin, CC
AF Cheung, Denise Shuk Ting
   Yeung, Wing Fai
   Chau, Pui Hing
   Lam, Tai Chung
   Yang, Mingxiao
   Lai, Kithelia
   Ip, Chun Yat
   Lao, Lixing
   Lin, Chia-Chin
TI Patient-centred, self-administered acupressure for Chinese advanced
   cancer patients experiencing fatigue and co-occurring symptoms: A pilot
   randomised controlled trial
SO EUROPEAN JOURNAL OF CANCER CARE
LA English
DT Article
DE acupressure; advanced cancer; fatigue; insomnia; pain; traditional
   Chinese medicine
ID QUALITY-OF-LIFE; VERSION; SLEEP; ANXIETY; INTERVENTION; DEPRESSION;
   MANAGEMENT; SURVIVORS; EXERCISE; INSOMNIA
AB Objectives To evaluate the feasibility and potential effects of patient-centred self-administered acupressure for alleviating fatigue and co-occurring symptoms among Chinese advanced cancer patients receiving treatment. Methods Thirty advanced cancer patients who screened positive for moderate/severe fatigue with symptoms of insomnia and/or pain were recruited from a hospital in Hong Kong. They were randomly assigned (1:1) to receive a 4-week patient-centred self-administered acupressure intervention or health education. Fatigue (primary outcome) and secondary outcomes (sleep quality, pain, fatigue-sleep disturbance-pain symptom cluster severity, anxiety, depression and quality of life) were measured by questionnaires and actigraphy. Results Twenty-four participants (80%) completed the study. Adherence to self-administered acupressure practice was satisfactory, with all retained participants attending all sessions and 90.9% practising acupressure daily. All completers rated the class as very enjoyable or quite enjoyable. Fatigue, pain, symptom cluster severity, anxiety, depression and quality of life appeared to improve from baseline to post-intervention in the intervention group. Among these outcomes, only the between-group difference in anxiety post-intervention was significant. The group x time interaction effect was nonsignificant for all outcomes. Conclusions Patient-centred self-administered acupressure appears to be feasible and acceptable among advanced cancer patients. A fully powered trial is warranted to confirm the intervention effect.
C1 [Cheung, Denise Shuk Ting; Chau, Pui Hing; Lin, Chia-Chin] Univ Hong Kong, Sch Nursing, Li Ka Shing Fac Med, Hong Kong, Peoples R China.
   [Yeung, Wing Fai] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Lam, Tai Chung] Univ Hong Kong, Li Ka Shing Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Yang, Mingxiao; Lao, Lixing] Univ Hong Kong, Sch Chinese Med, Li Ka Shing Fac Med, Hong Kong, Peoples R China.
   [Lai, Kithelia; Ip, Chun Yat] Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Lao, Lixing] Virginia Univ Integrat Med, Fairfax, VA USA.
   [Lin, Chia-Chin] Alice Ho Miu Ling Nethersole Char Fdn Prof Nursin, Hong Kong, Peoples R China.
   [Lin, Chia-Chin] Taipei Med Univ, Sch Nursing, Coll Nursing, Taipei, Taiwan.
C3 University of Hong Kong; Hong Kong Polytechnic University; University of
   Hong Kong; University of Hong Kong; University of Hong Kong; Alice Ho
   Miu Ling Nethersole Hospital; Taipei Medical University
RP Lin, CC (corresponding author), Univ Hong Kong, Sch Nursing, Li Ka Shing Fac Med, Pokfulam, 4-F William MW Mong Block Bldg,21 Sassoon Rd, Hong Kong, Peoples R China.
EM cclin@hku.hk
RI ; Yang, Mingxiao/ABF-6416-2021; Chau, Pui/A-2290-2010; Lam,
   Tai/U-1206-2019; Yeung, Wing-Fai/E-7971-2013; Lao, Lixing/P-9107-2019
OI LIN, Chia-Chin/0000-0001-9551-0991; Cheung, Denise Shuk
   Ting/0000-0002-8741-9271; Yang, Mingxiao/0000-0002-6514-3366; 
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NR 41
TC 34
Z9 37
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0961-5423
EI 1365-2354
J9 EUR J CANCER CARE
JI Eur. J. Cancer Care
PD SEP
PY 2022
VL 31
IS 5
AR e13314
DI 10.1111/ecc.13314
EA SEP 2020
PG 17
WC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Nursing; Rehabilitation
GA 4L4TF
UT WOS:000566654900001
PM 32896014
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Zhong, LLD
   Kun, W
   Lam, TF
   Zhang, SP
   Yang, JJ
   Ziea, TC
   Ng, B
   Bian, ZX
AF Zhong, Linda L. D.
   Kun, Wai
   Lam, Tsz Fung
   Zhang, Shi Ping
   Yang, Jun Jun
   Ziea, Tat Chi
   Ng, Bacon
   Bian, Zhao Xiang
TI The combination effects of body acupuncture and auricular acupressure
   compared to sham acupuncture for body weight control: study protocol for
   a randomized controlled trial
SO TRIALS
LA English
DT Article
ID CLINICAL-TRIAL; OBESE ADULTS; METAANALYSIS; OVERWEIGHT; EFFICACY;
   SAFETY; PAIN
AB Background: Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some types of cancer. Almost all the Western anti-obesity drugs have adverse effects or body weight is regained upon cessation of therapy. Recent studies have found that acupuncture had a similar efficacy as the Western anti-obesity drugs with fewer reported adverse effects. However, these conclusions were limited due to the small sample size and low quality of methodologies of these studies. Therefore, we design this study to explore the effectiveness and safety of acupuncture on weight control.
   Methods/design: This is a pilot single-blinded, randomized, sham-controlled trial on acupuncture for body weight control. Seventy-two participants are randomly assigned to the acupuncture group or the control group. Tianshu (ST-25), Daheng (SP-15), Daimai (GB-26), Qihai (CV-6), Zhongwan (CV-12), Zusanli (ST-36), Fenglong (ST-40), and Sanyinjiao (SP-6) are selected as acupuncture points. For the acupuncture group, disposable acupuncture needles will be inserted at a depth of 10-25 mm into the points and electrical stimulation with dense-disperse waves at 50 Hz and 10 V will be applied on the abdominal points. The bodily needles will be retained for 30 minutes. For subjects assigned to the control group, Streitberger's non-invasive acupuncture needles will be applied to serve as the sham control at the same acupoints with the same stimulation modality, except that the needles are only adhered to the skin instead of inserted. The duration of the treatment is 8 weeks with two sessions per week, and the follow-up period is 8 weeks. The primary outcome is the change in body weight before and after treatment. The secondary outcomes include changes in body mass index, waist circumference, hip circumference, and body fat percentage during the treatment and follow-up period.
   Discussion: The study will compare the efficacy and safety of acupuncture with sham acupuncture on weight control, in the hope of obtaining evidence for utilizing acupuncture for body weight control.
C1 [Zhong, Linda L. D.; Kun, Wai; Lam, Tsz Fung; Zhang, Shi Ping; Yang, Jun Jun; Bian, Zhao Xiang] Hong Kong Baptist Univ, Hong Kong Chinese Med Study Ctr, AAB 105, Kowloon, Hong Kong, Peoples R China.
   [Zhong, Linda L. D.; Kun, Wai; Lam, Tsz Fung; Zhang, Shi Ping; Bian, Zhao Xiang] Hong Kong Baptist Univ, Sch Chinese Med, 3-F,Jockey Club Sch Chinese Med Bldg, Kowloon, Hong Kong, Peoples R China.
   [Ziea, Tat Chi; Ng, Bacon] Hong Kong Hosp Author, Chinese Med Dept, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Baptist University; Hong Kong Baptist University
RP Bian, ZX (corresponding author), Hong Kong Baptist Univ, Hong Kong Chinese Med Study Ctr, AAB 105, Kowloon, Hong Kong, Peoples R China.; Bian, ZX (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, 3-F,Jockey Club Sch Chinese Med Bldg, Kowloon, Hong Kong, Peoples R China.
EM bzxiang@hkbu.edu.hk
RI Zhang, Shi/G-9793-2013; Ng, Bacon F L/I-5554-2013; Zhong,
   Linda/AAI-7376-2021
OI Ng, Bacon F L/0000-0003-1682-8382; Zhong, Linda/0000-0002-3877-1914
FU Hong Kong Hospital Authority Research Project: Acupuncture for Body
   Weight Control: A Pilot Randomized Controlled Trial [HA
   33-14-112-542-130]
FX This research was financially supported by Hong Kong Hospital Authority
   Research Project: Acupuncture for Body Weight Control: A Pilot
   Randomized Controlled Trial (Ref Code: HA 33-14-112-542-130).
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NR 20
TC 13
Z9 18
U1 1
U2 34
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUL 25
PY 2016
VL 17
AR 346
DI 10.1186/s13063-016-1458-2
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DR7UH
UT WOS:000380104700003
PM 27457720
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Laycock, H
   Ramdin, C
   Grayer, J
   Brown, MRD
AF Laycock, Helen
   Ramdin, Candice
   Grayer, Justin
   Brown, Matthew R. D.
TI Causes and management of acute oncological pain: a narrative review
SO ANAESTHESIA
LA English
DT Review
DE acute pain; cancer; mucositis; neuropathy; opioids; radiotherapy
ID INDUCED ORAL MUCOSITIS; INDUCED BONE PAIN; PALLIATIVE RADIOTHERAPY;
   POSTOPERATIVE PAIN; NORMAL TISSUE; CANCER PAIN; OPIOIDS; PREVALENCE;
   METASTASES; SURGERY
AB IntroductionAcute pain in cancer is an important but often overlooked feature of many patients' oncological journey. Cancer-related pain is associated commonly with more persistent pain states caused by both the disease and its treatment, but there are numerous causes of acute pain which can develop in patients with cancer. This pain is frequently severe, can be challenging to manage and its suboptimal control can directly impact on oncological outcomes. This narrative review provides an overview of several causes of acute pain in patients with cancer and management approaches.MethodsA focused literature review was conducted to encompass the search terms 'acute pain', 'oncology' and 'cancer' in adult and paediatric populations.ResultsAcute pain is common in patients with cancer with a number of pain generators identified. Broadly, these are disease- and treatment-related but commonality in pain mechanisms and features are present. Importantly, these pain states do not occur in isolation; a patient may experience multiple acute pain episodes during their oncology journey.DiscussionAs the oncological treatment landscape shifts and increasing numbers of novel treatments are employed, the number of causes of acute pain in patients with cancer rises. This pain is often managed by non-pain specialists and suboptimal control has a variety of deleterious effects. It is important that awareness of acute pain in the oncological population is increased and treatment approaches, which adopt a biopsychosocial structure, are optimised.
C1 [Laycock, Helen] Great Ormond St Hosp Sick Children, Dept Pain Med, London, England.
   [Ramdin, Candice] San Fernando Gen Hosp, Southwest Reg Hlth Author, Dept Pain Med, San Fernando, Trinidad Tobago.
   [Grayer, Justin] Royal Marsden Hosp, Adult Psychol Support Serv, London, England.
   [Brown, Matthew R. D.] Royal Marsden Hosp, Dept Pain Med, London, England.
   [Brown, Matthew R. D.] Inst Canc Res, London, England.
C3 University of London; University College London; Great Ormond Street
   Hospital for Children NHS Foundation Trust; Royal Marsden NHS Foundation
   Trust; Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation
   Trust; University of London; Institute of Cancer Research - UK
RP Brown, MRD (corresponding author), Royal Marsden Hosp, Dept Pain Med, London, England.; Brown, MRD (corresponding author), Inst Canc Res, London, England.
EM matthew.brown@rmh.nhs.uk
RI Laycock, Helen/A-2190-2014; Brown, Matthew/HIZ-8325-2022
OI Laycock, Helen/0000-0003-2903-0038; 
FU NHS; Royal Marsden/Institute of Cancer Research NIHR Biomedical Research
   Centre; Boston Scientific Corporation; Medtronic plc
FX The authors acknowledge NHS funding to the Royal Marsden/Institute of
   Cancer Research NIHR Biomedical Research Centre. HL is an Editor of
   Anaesthesia. MB has undertaken paid consulting work for Phytome Life
   Sciences, Boston Scientific Corporation, Curonix and Medtronic plc. No
   data or statistical code were generated. No other competing interests
   declared.
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NR 90
TC 1
Z9 1
U1 3
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0003-2409
EI 1365-2044
J9 ANAESTHESIA
JI Anaesthesia
PD FEB
PY 2025
VL 80
SU 2
SI SI
BP 95
EP 105
DI 10.1111/anae.16512
EA JAN 2025
PG 11
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA U6I7Q
UT WOS:001391285700001
PM 39777687
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Yu, ML
   Qian, JJ
   Fu, SP
   Chen, JY
   Zheng, YW
   Lu, ZG
   Lu, SF
AF Yu, Mei-ling
   Qian, Jia-jia
   Fu, Shu-ping
   Chen, Jia-ying
   Zheng, Yu-wen
   Lu, Zhi-gang
   Lu, Sheng-feng
TI Acupuncture for Cancer-Induced Bone Pain in Animal Models: A Systemic
   Review and Meta-Analysis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID BREAKTHROUGH PAIN; ELECTROACUPUNCTURE; PREVALENCE; MANAGEMENT;
   MECHANISMS; EXPRESSION
AB Background. Cancer-induced bone pain (CIBP) is a highly prevalent symptom, which afflicts vast majority of patients who suffer from cancer. The current treatment options failed to achieve satisfactory effect and the side effects were prominent. Recent randomized controlled trials (RCTs) of animal demonstrate the benefit of acupuncture for CIBP. We sought to determine if the pooled data from available RCTs supports the use of acupuncture for CIBP.Methods. A literature search for randomized controlled trials was conducted in six electronic databases from inception to May 31, 2019. Meta-analysis was performed with Review Manager 5.3 software; the publication bias was assessed by Stata 12.0 software. We used random effects model for pooling data because heterogeneity is absolute among studies to some extent.Results. Twenty-four trials were included in the review, of which 12 trials provided detailed data for meta-analyses. Preliminary evidence indicates that compared to wait list/sham group, acupuncture was effective on increasing paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). Compared to medicine, acupuncture was less effective on PWT, but as effective as medicine on PWL. Acupuncture can reinforce medicine's effect on PWT and PWL. Compared to the control group, acupuncture was superior to increase body weight (BW), decrease spinal cord glial fibrillary acidic protein (GFAP), and interleukin-1 beta(IL-1 beta). Furthermore, some studies showed acupuncture delay or partially reverse morphine tolerance. Three studies found acupuncture has no effect on PWT, but 2 of them found acupuncture could enhance small dose of Celebrex's effect on CIBP.Conclusions. Acupuncture was superior to wait list/sham acupuncture on increasing PWT and has no less effect on increasing PWL compared to medicine; acupuncture improved the efficacy of drugs, increased the CIBP animals' body weight, and decreased their spinal cord GFAP and IL-1 beta. High-quality studies are necessary to confirm the results.
C1 [Yu, Mei-ling; Qian, Jia-jia; Lu, Zhi-gang] Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210023, Peoples R China.
   [Yu, Mei-ling; Qian, Jia-jia; Chen, Jia-ying; Zheng, Yu-wen] Nanjing Univ Chinese Med, Acupuncture & Rehabil Coll, Nanjing 210023, Peoples R China.
   [Fu, Shu-ping; Lu, Sheng-feng] Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing 210023, Peoples R China.
   [Lu, Zhi-gang] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Nanjing University of
   Chinese Medicine
RP Lu, ZG (corresponding author), Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210023, Peoples R China.; Lu, SF (corresponding author), Nanjing Univ Chinese Med, Key Lab Acupuncture & Med Res, Minist Educ, Nanjing 210023, Peoples R China.; Lu, ZG (corresponding author), Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.
EM Luzg@njucm.edu.cn; lushengfeng@njucm.edu.cn
OI Fu, Shu-Ping/0000-0002-8328-148X; lu, zhigang/0000-0001-6769-3647; Fu,
   Shuping/0000-0002-4047-9330
FU National Natural Science Foundation of China [81774210, 81574062]; "Six
   Major Talent Summit" of Jiangsu Province [YY-033]; Jiangsu Province "333
   High-Level Talents Cultivating Project (2016); Qing Lan Project" of
   Jiangsu Province; Nursing Priority Academic Program Development of
   Jiangsu Higher Education Institutions [2019YSHL059, 2019YSHL046]
FX This work was supported by the National Natural Science Foundation of
   China (nos. 81774210 and 81574062), "Six Major Talent Summit" of Jiangsu
   Province (YY-033), Jiangsu Province "333 High-Level Talents Cultivating
   Project" (2016), "Qing Lan Project" of Jiangsu Province, and a Project
   Funded by the Nursing Priority Academic Program Development of Jiangsu
   Higher Education Institutions (2019YSHL059 and 2019YSHL046).
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NR 45
TC 1
Z9 2
U1 1
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUL 30
PY 2020
VL 2020
AR 5606823
DI 10.1155/2020/5606823
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ND3NA
UT WOS:000561809300007
PM 32802130
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Bao, T
   Seidman, AD
   Piulson, L
   Vertosick, E
   Chen, X
   Vickers, AJ
   Blinder, VS
   Zhi, WQI
   Li, Q
   Vahdat, LT
   Dickler, MN
   Robson, ME
   Mao, JJ
AF Bao, Ting
   Seidman, Andrew D.
   Piulson, Lauren
   Vertosick, Emily
   Chen, Xi
   Vickers, Andrew J.
   Blinder, Victoria S.
   Zhi, Wanqing I.
   Li, Qing
   Vahdat, Linda T.
   Dickler, Maura N.
   Robson, Mark E.
   Mao, Jun J.
TI A phase IIA trial of acupuncture to reduce chemotherapy-induced
   peripheral neuropathy severity during neoadjuvant or adjuvant weekly
   paclitaxel chemotherapy in breast cancer patients
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Article
DE Breast cancer; Acupuncture; Chemotherapy-induced peripheral neuropathy;
   CIPN; Paclitaxel; Chemotherapy
ID SMALL FIBER NEUROPATHY; PAIN; ELECTROACUPUNCTURE; PREVENTION
AB Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially dose-limiting side-effect of neurotoxic chemotherapy for cancer patients. We evaluated the preliminary efficacy of acupuncture in preventing worsening CIPN in patients receiving paclitaxel.
   Methods: In this phase IIA single-arm clinical trial, we screened stage I-III breast cancer patients receiving neoadjuvant/adjuvant weekly paclitaxel for development of CIPN. The primary objective was to assess acupuncture's efficacy in preventing the escalation of National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI-CTCAE), version 4.0, grade II CIPN to higher grades. Acupuncture was deemed worthy of further study if 23 or more of the 27 enrolled patients did not develop grade III CIPN. Outcome measures (NCI-CTCAE CIPN grade, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity [FACT/GOG-Ntx], Neuropathic Pain Scale [NPS]) were obtained weekly during the intervention.
   Results: Of 104 patients screened, 37 developed grade II CIPN (36%), and 28 (27%) enrolled into the intervention phase; one was removed due to protocol violation. Of the 27 patients receiving acupuncture, 26 completed paclitaxel treatment without developing grade III CIPN, meeting our prespecified success criteria for declaring acupuncture worthy of further study. FACT/GOG-Ntx and NPS scores remained stable during the intervention while continuing weekly paclitaxel. Acupuncture treatment was well tolerated; 4 of 27 (15%) patients reported grade I bruising.
   Conclusions: Acupuncture was safe and showed preliminary evidence of effectiveness in reducing the incidence of high grade CIPN during chemotherapy. A follow-up randomised controlled trial is needed to establish definitive efficacy in CIPN prevention for patients at risk. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Bao, Ting; Piulson, Lauren; Li, Qing; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, 1429 First Ave, New York, NY 10021 USA.
   [Seidman, Andrew D.; Vahdat, Linda T.; Dickler, Maura N.; Robson, Mark E.] Mem Sloan Kettering Canc Ctr, 300 East 66th St, New York, NY 10065 USA.
   [Vertosick, Emily; Vickers, Andrew J.; Blinder, Victoria S.] Mem Sloan Kettering Canc Ctr, 485 Lexington Ave, New York, NY 10017 USA.
   [Chen, Xi] Mem Sloan Kettering Canc Ctr, 444 E 68th St, New York, NY 10065 USA.
   [Zhi, Wanqing I.] Mem Sloan Kettering Canc Ctr Commack, 650 Commack Rd, Commack, NY 11725 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering
   Cancer Center
RP Bao, T (corresponding author), Bendheim Integrat Med Ctr, 1429 First Ave, New York, NY 10021 USA.
EM baot@mskcc.org; seidmana@mskcc.org; piulsonl@mskcc.org;
   vertosie@mskcc.org; chenx2@mskcc.org; vickersa@mskcc.org;
   blinderv@mskcc.org; zhiw@mskcc.org; liq2@mskcc.org; vahdatl@mskcc.org;
   dicklerm@mskcc.org; robsonm@mskcc.org; maoj@mskcc.org
OI Vickers, Anew/0000-0003-1525-6503; Bao, Ting/0000-0003-4437-2597; Zhi,
   Iris/0000-0003-4263-7272; Vahdat, Linda/0000-0002-3522-7382
FU National Cancer Institute [R21CA173263, R01CA158243]; Memorial Sloan
   Kettering Cancer Center P30 grant [P30-CA008748]; Byrne Fund at Memorial
   Sloan Kettering Cancer Center; Translational Research and Integrative
   Medicine Fund at Memorial Sloan Kettering Cancer Center; National Cancer
   Institute [P30CA008748] Funding Source: NIH RePORTER
FX This work was supported by the National Cancer Institute [R21CA173263,
   Bao and R01CA158243, Mao]; a Memorial Sloan Kettering Cancer Center P30
   grant [P30-CA008748] and the Byrne Fund and the Translational Research
   and Integrative Medicine Fund, both at Memorial Sloan Kettering Cancer
   Center. The funding sources had no involvement in the study design;
   collection, analysis and interpretation of data; writing of the report
   or decision to submit the article for publication.
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NR 33
TC 82
Z9 97
U1 2
U2 53
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0959-8049
EI 1879-0852
J9 EUR J CANCER
JI Eur. J. Cancer
PD SEP
PY 2018
VL 101
BP 12
EP 19
DI 10.1016/j.ejca.2018.06.008
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GQ7BP
UT WOS:000441888700002
PM 30007894
DA 2026-01-16
ER

PT J
AU Li, XT
   Zhi, L
   Han, KY
   Li, SQ
   Ahmad, K
   Seluzicki, C
   Wang, R
   Bao, T
AF Li, Xiaotong
   Zhi, Lilly
   Han, Katherine Y.
   Li, Susan Q.
   Ahmad, Khalada
   Seluzicki, Christina
   Wang, Rui
   Bao, Ting
TI Impact of Baseline Expectancy on Outcome Prediction of Real and Sham
   Acupuncture for Persistent Chemotherapy-Induced Peripheral Neuropathy
   Pain in Solid Tumor Survivors: A Secondary Analysis of a Randomized
   Clinical Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture expectancy; acupuncture; chemotherapy-induced peripheral
   neuropathy; sham acupuncture; pain
ID PREVENTION; VALIDATION; MANAGEMENT; SCALE
AB Background:Chemotherapy-induced peripheral neuropathy (CIPN) pain significantly worsens cancer survivors' quality of life. Expectancy may play an important role in acupuncture response. We sought to explore whether expectancy predicts pain outcome in real acupuncture (RA) and sham acupuncture (SA) in cancer survivors. Methods:We analyzed data from a randomized clinical trial that evaluated the effect of RA on CIPN symptoms compared to SA and wait list control (WLC) in 75 cancer survivors. This secondary analysis was limited to CIPN pain measured by the Numeric Rating Scale (NRS), graded from 0 to 10. Interventions were delivered over 8 weeks. SA was implemented using a combination of non-acupuncture points and a non-insertion procedure. Patient expectancy was measured by the Acupuncture Expectancy Scale (AES) 3 times during the study. We used a linear regression model to evaluate if the NRS score was associated with the baseline AES score at the end of treatment (week 8), adjusting for baseline NRS score. Results:AES was similar among 3 groups at baseline (RA: 11.8 & PLUSMN; 2.7; SA: 12.1 & PLUSMN; 3.8.; WLC: 14.6 & PLUSMN; 4.2; P = .062). Baseline AES was not found to be significantly associated with the week 8 NRS score among patients in all RA, SA, and WLC groups (all P > .05). However, we found a trend that higher baseline AES predicted lower NRS score at week 8 in the SA group: a one-point higher score on baseline expectancy was associated with a 0.3-point reduction in NRS pain score (P = .059) at week 8. Conclusions:The association of baseline expectancy and acupuncture response was similar between RA and SA. However, SA seemed to rely more on expectancy than RA. Further studies with larger sample sizes are needed to confirm this finding.
C1 [Li, Xiaotong; Han, Katherine Y.; Li, Susan Q.; Seluzicki, Christina; Wang, Rui; Bao, Ting] Mem Sloan Kettering Canc Ctr, New York, NY USA.
   [Zhi, Lilly] Ward Melville High Sch, East Setauket, NY USA.
   [Ahmad, Khalada] Advent Hlth Great Lakes Reg, Advent Hlth Canc Inst Clin Res, Hinsdale, IL USA.
   [Bao, Ting] Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,4th Floor, New York, NY 10065 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Integrat Med Serv, 321 East 61st St,4th Floor, New York, NY 10065 USA.
EM baot@mskcc.org
RI ; Li, Xiaotong/HTN-2157-2023
OI Seluzicki, Christina/0000-0002-8553-6810; 
FU National Cancer Institute [P30CA008748] Funding Source: NIH RePORTER;
   NCI NIH HHS [R37 CA248563, R01 CA251470, P30 CA008748] Funding Source:
   Medline
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NR 30
TC 7
Z9 7
U1 2
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354221149992
DI 10.1177/15347354221149992
PG 8
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA R0DV3
UT WOS:001061139200001
PM 36691937
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Meng, HSL
   Yu, H
   Gang, SH
   Bo, A
   Wang, ZL
AF Meng, Husileng
   Yu, Hong
   Gang, Suhe
   Bo, Agula
   Wang, Zhanli
TI Therapeutic effects of Mongolian medical warm acupuncture on neuropathic
   pain via gut microbiota and inflammatory pathway regulation in a chronic
   constriction injury rat model
SO ARCHIVES OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Mongolian medical warm acupuncture; neuropathic pain; chronic
   constriction injury; gut microbiota; inflammation
AB The study was designed to determine whether Mongolian medical warm acupuncture (MMWA) can alleviate neuropathic pain through regulating gut microbiota and inflammation-related pathways in the chronic constriction injury (CCI) rat model. Rats were randomly divided into three groups: sham, model, and treatment. A bilateral chronic constriction injury (CCI) was induced to establish a rat model of neuropathic pain. Rats in the treatment group received MMWA at the Heyi and Shen acupoints once daily for seven consecutive days. Pain-related behaviors were evaluated using mechanical pain threshold and thermal withdrawal latency measurements. The mRNA levels of c-fos in spinal dorsal horns were determined using real-time PCR. Gut microbiota was analyzed by 16S ribosomal RNA sequencing. Interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha were evaluated by enzyme-linked immunosorbent assay (ELISA) analysis. MMWA could relieve behavioral symptoms (P<0.01). MMWA intervention significantly suppressed the expression of c-fos in CCI rats (P<0.05). The relative abundance of gut bacteria was disturbed in CCI rats, with the microbiota disorder ameliorated by MMWA. KEGG enrichment analysis revealed that changes in gut microbiota were associated with the pentose and glucuronate interconversion pathway and secondary bile acid biosynthesis. The concentrations of IL-1 beta, IL-6, and TNF-alpha in CCI rats were increased (P<0.05), an effect that was reversed by MMWA intervention (P<0.05). The current study indicated that the MMWA could effectively alleviate neuropathic pain by modulating gut microbiota and inhibiting inflammation in the CCI rat model, suggesting that gut microbiota could be a promising potential biological target for treating neuropathic pain.
C1 [Meng, Husileng; Gang, Suhe; Bo, Agula] Inner Mongolia Med Univ, Mongolian Med Sch, 5 Xinhua St, Hohhot, Peoples R China.
   [Yu, Hong; Bo, Agula; Wang, Zhanli] Baotou Med Coll, Affiliated Hosp 2, Inner Mongolia Key Lab Dis Related Biomarkers, 30 Hudemulin Ave, Baotou, Peoples R China.
C3 Inner Mongolia Medical University; Baotou Medical College
RP Bo, A (corresponding author), Inner Mongolia Med Univ, Mongolian Med Sch, 5 Xinhua St, Hohhot, Peoples R China.; Bo, A; Wang, ZL (corresponding author), Baotou Med Coll, Affiliated Hosp 2, Inner Mongolia Key Lab Dis Related Biomarkers, 30 Hudemulin Ave, Baotou, Peoples R China.
EM agula372000@126.com; wang.zhanli@hotmail.com
FU National Natural Science Foundation of China [82460987, 82074577,
   82260092]; Natural Science Foundation of Inner Mongolia Autonomous
   Region of China [2023ZD01, 2023QN08065]
FX Funding: This study was supported by the National Natural Science
   Foundation of China (no. 82460987, 82074577, and 82260092) , and the
   Natural Science Foundation of Inner Mongolia Autonomous Region of China
   (2023ZD01 and 2023QN08065) .
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NR 40
TC 0
Z9 0
U1 0
U2 0
PU INST BIOLOSKA ISTRAZIVANJA SINISA STANKOVIC
PI BEOGRAD
PA 29 NOVEMBRA 142, BEOGRAD, 11060, SERBIA
SN 0354-4664
EI 1821-4339
J9 ARCH BIOL SCI
JI Arch. Biol. Sci.
PY 2025
VL 77
IS 3
BP 225
EP 236
DI 10.2298/ABS250531018M
PG 12
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA AN1GV
UT WOS:001652051700002
OA gold
DA 2026-01-16
ER

PT J
AU Xu, H
   Fan, YY
   Meng, XZ
   Luan, J
   Guan, H
   Su, XL
   Xu, LX
   Lu, DP
AF Xu, Hao
   Fan, Yingying
   Meng, Xiangzhong
   Luan, Jing
   Guan, Hua
   Su, Xianli
   Xu, Lixian
   Lu, Dominic P.
TI Use of Acupoint Stimulation to Regulate Perioperative Stress-Induced
   Immunosuppression
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Article
DE Acupuncture stimulation; Immunosuppression; Perioperative period;
   Postoperative recovery; Stress response
ID ACUPUNCTURE; IMMUNE; ELECTROACUPUNCTURE; ANESTHESIA; ENDORPHIN
AB The stress response can be triggered during the perioperative period by tension, fear, anesthesia, surgical trauma, and various postoperative adverse stimuli, leading to significant changes in the endocrine, metabolic, and immune systems of patients. In particular, immunosuppression induced by the stress response has adverse effects on the postoperative recovery of patients. As acupuncture stimulation-related technologies have been rapidly developed and applied in recent years, a number of basic and clinical studies have confirmed that acupoint stimulation can regulate the immune system via local, neurological, and endocrine pathways. Moreover, acupoint stimulation treatment has also been shown to reduce the adverse effects of immunosuppression by affecting the release of various cytokines, such as interleukin (IL) 1, IL-2, IL-4, IL-6, IL-10, IFN-gamma, and tumor necrosis factor (TNF) beta, immunoglobulins, complement proteins, and T cell markers such as CD3, CD4, and CD4/CD8 via the regulation of macrophages, neutrophils, NK cells, and endogenous opioids. In addition, acupuncture stimulation treatment during the perioperative period can also significantly decrease the amount of anesthetic required for anesthesia, effectively reduce nausea and vomiting, relieve post-operative pain, and accelerate the recovery of physiological functions. Therefore, acupuncture stimulation treatment has shown important potential for clinical applications.
C1 [Xu, Hao; Su, Xianli] Xian Med Univ, Inst Basic Med Sci, Xian, Peoples R China.
   [Fan, Yingying; Meng, Xiangzhong; Luan, Jing; Guan, Hua; Xu, Lixian] Fourth Mil Med Univ, Dept Anesthesiol, Sch Stomatol, Xian, Peoples R China.
   [Lu, Dominic P.] Univ Penn, Oral & Maxillofacial Surg, Philadelphia, PA 19104 USA.
C3 Xi'an Medical University; Air Force Medical University; University of
   Pennsylvania
RP Su, XL (corresponding author), Xian Med Univ, Inst Basic Med Sci, Xian, Peoples R China.; Xu, LX (corresponding author), Fourth Mil Med Univ, Dept Anesthesiol, Sch Stomatol, Xian, Peoples R China.
EM 20867934@qq.com; xlx116@fmmu.edu.cn
RI Su, Xianli/NRY-0249-2025
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   Aoki E, 2005, IN VIVO, V19, P495
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NR 39
TC 1
Z9 1
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PY 2020
VL 44
IS 3-4
BP 203
EP 212
DI 10.3727/036012920X15779969212946
PG 10
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA KM0ZL
UT WOS:000513846500003
DA 2026-01-16
ER

PT J
AU Yan, J
   Jiang, SY
   Zhou, X
   Zhao, M
   Huang, JL
   Zhu, HM
   Huang, BY
   Li, EM
   Chang, H
AF Yan, Jun
   Jiang, Suying
   Zhou, Xuan
   Zhao, Mei
   Huang, Jinliang
   Zhu, Huimeng
   Huang, Bingyao
   Li, Ermei
   Chang, Hong
TI Use of the improved tug-of-war acupuncture for promoting cartilage
   repair by inducing macrophage polarization in knee osteoarthritis
SO HELIYON
LA English
DT Article
DE Knee osteoarthritis; Tug of war acupuncture; Macrophage polarization
ID MANUAL ACUPUNCTURE; ELECTROACUPUNCTURE; PAIN
AB Introduction: Knee osteoarthritis (KOA) is a type of joint disease causing degenerative changes that are challenging to treat. The improved tug-of-war acupuncture (BHZF) can improve joint pain in KOA. However, the associated mechanism has not been validated. Methods: The KOA rabbit model was established. After the surgery, the improved BHZF was provided as an intervention, and the animals were euthanized after 2 weeks. Histopathological changes in the synovium and cartilage were observed on hematoxylin & eosin staining and Safranin O-Fast Green staining. Synovial fluid and serum samples were collected to assess the presence of cytokines using the enzyme-linked immunosorbent assay. The expression of M1 macrophage (CD86) and M2 macrophage (ARG1) markers in the cartilage and synovium was detected via immunohistochemistry and immunofluorescence assays. Results: The improved BHZF could reduce KOA-related pain and inhibit joint swelling. Further, it significantly maintained the morphology of articular chondrocytes in KOA and reduced the decomposition of the cartilage matrix. Then, it significantly reduced the expression of CD86positive cells (P < 0.05), and increased the expression of ARG1-positive cells in the cartilage and synovium (P < 0.05). Moreover, it significantly decreased the expression of inflammatory factors interleukin (IL)-1 beta and tumor necrosis factor-alpha in the serum and synovial fluid (P < 0.05), and significantly increased the expression levels of anti-inflammatory cytokines IL-4 and IL-10 (P < 0.05). Conclusions: The improved BHZF can relieve pain and improve cartilage damage by regulating macrophage polarization in KOA.
C1 [Yan, Jun; Zhou, Xuan; Zhao, Mei; Huang, Jinliang; Zhu, Huimeng; Huang, Bingyao; Li, Ermei] Shenzhen Hosp Integrated Tradit Chinese & Western, Dept Rehabil, Shenzhen 518104, Guangdong, Peoples R China.
   [Jiang, Suying] Shenzhen Hosp Integrated Tradit Chinese & Western, Hosp Infect Control Sect, Shenzhen 518104, Guangdong, Peoples R China.
   [Chang, Hong] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou 510000, Guangdong, Peoples R China.
   [Chang, Hong] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, 19 Nonglin Xia Rd, Guangzhou 510000, Guangdong, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
RP Chang, H (corresponding author), Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, 19 Nonglin Xia Rd, Guangzhou 510000, Guangdong, Peoples R China.
EM chong181@126.com
FU Traditional Chinese Medicine Bureau of Guangdong Province, China
   [20231282]; Bao'an TCM Devel- opment Foundation [2020KJCX-KTYJ-140];
   Sanming Project of Medicine in Shenzhen [SZZYSM202106009]
FX This work was funded by Traditional Chinese Medicine Bureau of Guangdong
   Province, China (20231282) ; Bao'an TCM Devel- opment Foundation
   (2020KJCX-KTYJ-140) ; Sanming Project of Medicine in Shenzhen
   (SZZYSM202106009) .
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NR 31
TC 2
Z9 2
U1 4
U2 10
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD FEB 29
PY 2024
VL 10
IS 4
AR e25495
DI 10.1016/j.heliyon.2024.e25495
EA FEB 2024
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LD9D1
UT WOS:001184950200001
PM 38384563
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Rizi, MS
   Shamsalinia, A
   Ghaffari, F
   Keyhanian, S
   Nabi, BN
AF Rizi, Moloud Sharifi
   Shamsalinia, Abbas
   Ghaffari, Fatemeh
   Keyhanian, Shahrbanoo
   Nabi, Bahram Naderi
TI The effect of acupressure on pain, anxiety, and the physiological
   indexes of patients with cancer undergoing bone marrow biopsy
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Acupressure; Pain; Anxiety; Physiological indexes; Bone marrow; Biopsy;
   Aspiration
ID AURICULAR ACUPRESSURE; PREOPERATIVE ANXIETY; ASPIRATION; FATIGUE; BLIND
AB Objectives: This study aimed to determine the effect of acupressure on pain intensity, anxiety, and physiological indexes of patients with cancer undergoing bone marrow biopsy and aspiration.
   Methods: The study was designed as a randomized, double-blinded, controlled trial. Ninety samples was selected using the convenience sampling method, then for allocation groups random block sampling was used (30 for each group). The three groups were similar by age and gender. LI4 and HT7 (Shen Men) acupressure points were examined for the intervention. Sham pressure was used in the placebo group while no intervention was applied in the control group.
   Results: The results showed that the lowest average anxiety score (1.5 +/- 0.5; P = 0.01) and the lowest average pain score (4.9 +/- 0.8) after the intervention were related to the acupressure method (P = 0.001).
   Conclusion: Cost effectiveness and short-term simple education make acupressure method useful in clinical settings for different illnesses. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Rizi, Moloud Sharifi; Shamsalinia, Abbas; Ghaffari, Fatemeh] Babol Univ Med Sci, Ramsar Nursing Care Res Ctr, Babol Sar 4691714141, Mazandaran, Iran.
   [Keyhanian, Shahrbanoo] Azad Univ Tonekabon, Dept Oncol, Tonekabon, Mazandaran, Iran.
   [Nabi, Bahram Naderi] Guilan Univ Med Sci, Anesthesiol Res Ctr, Anesthesiol Dept, Rasht, Iran.
C3 Babol University of Medical Sciences; Guilan University of Medical
   Sciences
RP Ghaffari, F (corresponding author), Babol Univ Med Sci, Ramsar Nursing Care Res Ctr, Babol Sar 4691714141, Mazandaran, Iran.
EM sharifi.molod@gmail.com; abbasshamsalinia@yahoo.com;
   ghafarifateme@yahoo.com; Keyhani_333@yahoo.com; naderi_bahram@gums.ac.ir
RI naderi nabi, bahram/G-4079-2017; ghaffari, fatemeh/I-4206-2016
OI naderi nabi, bahram/0000-0002-1727-2446; shaalinia,
   abbas/0000-0001-7423-7607; Keyhanian, Shahrbanoo/0000-0003-3810-4131;
   ghaffari, fatemeh/0000-0003-1940-1579
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NR 34
TC 47
Z9 53
U1 1
U2 30
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD NOV
PY 2017
VL 29
BP 136
EP 141
DI 10.1016/j.ctcp.2017.09.002
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA FN6ZM
UT WOS:000416166000015
PM 29122251
DA 2026-01-16
ER

PT J
AU Mao, QJ
   Huang, B
   Zhu, DC
   Wang, YQ
   Xu, SQ
   Wu, DS
   Huang, GM
   Li, ZR
   Chi, ZH
   Chen, RX
AF Mao, Qiangjian
   Huang, Biao
   Zhu, Daocheng
   Wang, Yuqing
   Xu, Shiqi
   Wu, Desheng
   Huang, Guomin
   Li, Ziru
   Chi, Zhenhai
   Chen, Rixin
TI A Bibliometric Analysis of Acupuncture Therapy in the Treatment of
   Musculoskeletal Pain from 2003 to 2022
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE musculoskeletal pain; acupuncture therapy; bibliometrics; CiteSpace
ID LOW-BACK-PAIN; BREAST-CANCER PATIENTS; CHRONIC KNEE PAIN; SYSTEMATIC
   REVIEWS; TRIALS; ELECTROACUPUNCTURE; OSTEOARTHRITIS; METAANALYSIS;
   MULTICENTER; BLIND
AB Background: Acupuncture therapy has been widely used in the treatment of musculoskeletal pain (MP) in many countries around the world. However, there are no bibliometric studies on acupuncture therapy for MP. Therefore, the aim of this study was to analyze the current status, frontiers and hot spots in the use of acupuncture therapy for the treatment of MP.Methods: Literature on acupuncture therapy for MP was extracted from the Web of Science Core Collection database from 2003 to 2022. CiteSpace 6.2.R4 (64-bit) software was used to analyze the number and centrality of journals, countries, institutions, authors, references and keywords, and the functions of co-occurrence and clustering were applied to draw a visual knowledge map.Results: Over the past 20 years, the annual journal publications have been on a steady upward trend, with 438 articles published in 143 journals, including Acupuncture in Medicine Journal published the most (28, 6.39%), JAMA-Journal of the American Medical Association was the journal with the highest impact factor (IF = 120.7003), USA dominated with the most publications (140, 31.96%) among 44 countries, and among 196 research organizations Kyung Hee University was the most prolific (19, 4.34%) and Ha, In-Hyuk was the most published author (9, 2.05%). "Acupuncture" is the most popular and highly sought after keywords. "Low back pain" is the keyword with the highest centrality.Conclusion: This article provides the current situation of the use of acupuncture therapy in the treatment of MP in the past 20 years, and statistical analysis reveals that "low back pain", "knit osteoporosis" and "break cancer" are new research diseases related to acupuncture therapy for MP, and "myobasic trigger point" is a new research direction of acupuncture therapy for MP. Therefore, this study helps researchers grasp the research hotspots and provide certain references for in-depth research and future topic selection.
C1 [Mao, Qiangjian; Huang, Biao; Zhu, Daocheng; Wu, Desheng; Huang, Guomin; Li, Ziru; Chi, Zhenhai; Chen, Rixin] Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.
   [Wang, Yuqing; Xu, Shiqi] Jiangxi Univ Chinese Med, Nanchang, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine
RP Chi, ZH; Chen, RX (corresponding author), Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.
EM 348916661@qq.com; chenrixin321@163.com
RI ; xu, shiqi/KEH-9943-2024
OI mao, qiangjian/0000-0003-4892-2058; 
FU 2022 National Famous Elderly Chinese Medicine Experts Inheritance
   Workshop Construction Project [75]; National TCM Human Education Letter
   [75, 1]; 2022 National Famous Chinese Medicine Experts Inheritance
   Workshop Construction Project; Jiangxi Provincial Administration of
   Traditional Chinese Medicine [1]; Jiangxi Provincial Traditional Chinese
   Medicine Medical Thermal Acupuncture and Moxibustion Quality Control
   Centers; Gan Traditional Chinese Medicine Medical Policy Letter; Jiangxi
   Provincial Administration of Traditional Chinese Medicine Key Research
   Laboratory Construction Project of Pediatric Tuina [8]
FX his study was funded by the 2022 National Famous Elderly Chinese
   Medicine Experts Inheritance Workshop Construction Project (NO: National
   TCM Human Education Letter [2022] No. 75) , the 2022 National Famous
   Chinese Medicine Experts Inheritance Workshop Construction Project (NO:
   Prof. Rixin Chen) , the Jiangxi Provincial Administration of Traditional
   Chinese Medicine's proposal for the establishment of the second batch of
   Jiangxi Provincial Traditional Chinese Medicine Medical Thermal
   Acupuncture and Moxibustion Quality Control Centers (NO: Gan Traditional
   Chinese Medicine Medical Policy Letter [2023] No. 1) and the Jiangxi
   Provincial Administration of Traditional Chinese Medicine Key Research
   Laboratory Construction Project of Pediatric Tuina (NO: Gan TCM Science
   and Education Letter [2022] No. 8) were funded.
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NR 76
TC 3
Z9 4
U1 6
U2 28
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2023
VL 16
BP 3853
EP 3870
DI 10.2147/JPR.S431689
PG 18
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Y0QO6
UT WOS:001102403200001
PM 38026461
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, WL
   Qdaisat, A
   Lopez, G
   Narayanan, S
   Underwood, S
   Spano, M
   Reddy, A
   Guo, Y
   Yeung, SC
   Bruera, E
   Cohen, L
AF Liu, Wenli
   Qdaisat, Aiham
   Lopez, Gabriel
   Narayanan, Santhosshi
   Underwood, Susan
   Spano, Michael
   Reddy, Akhila
   Guo, Ying
   Yeung, Sai-Ching
   Bruera, Eduardo
   Cohen, Lorenzo
TI Association Between Acupoint Selection, Target Symptoms, and Traditional
   Chinese Medicine Diagnosis in Real-Time Clinical Practice in a
   Comprehensive Cancer Center
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; acupuncture point selection; traditional Chinese medicine;
   integrative medicine; cancer; complementary health approaches
ID ACUPUNCTURE
AB Background: Acupuncture intervention in actual practice is rarely reported and may be different from that applied in acupuncture research. Objectives: To review acupuncture practice in an integrative medicine clinic and characterize the association between targeted symptoms, traditional Chinese medicine (TCM) diagnosis, and acupoint selection. Methods: We reviewed outpatient acupuncture records from March 2016 to April 2018. Statistical analyses were applied to characterize referral symptoms and associated TCM diagnosis as well as acupoint selection. Results: The final analysis included 5393 acupuncture records (1264 patients). Twelve TCM diagnosis components were identified in the referral symptoms of pain, neuropathy, xerostomia, and hot flashes. Pain was associated with 78 different TCM diagnoses (combinations of TCM diagnosis components). Total of 217 different acupoints were used in the acupuncture treatments (1739) for neuropathy. The acupoint yintang was used in 73.8% of the visits for neuropathy, yet only in 26.5% (P < .001) of the treatments when patients had a TCM diagnosis of qi deficiency, qi stagnation, and blood stagnation. Similarly, both consistencies and variations were seen in acupoint selection with each targeted symptom and its associated TCM diagnoses. Conclusions: TCM diagnosis was not homogeneous among acupuncture treatments for a single referral symptom. In contrast to most of the research on acupuncture for symptom control, there were considerable variations in acupoint selection among treatments for the same symptom in a clinical setting. Future research is needed to examine the clinical relevance of a fixed intervention structure in acupuncture research and the value of individualized acupuncture treatment.
C1 [Liu, Wenli; Qdaisat, Aiham; Lopez, Gabriel; Narayanan, Santhosshi; Underwood, Susan; Spano, Michael; Reddy, Akhila; Guo, Ying; Yeung, Sai-Ching; Bruera, Eduardo; Cohen, Lorenzo] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Liu, WL (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Palliat Care Rehabil & Integrat Med, 1515 Holcombe Blvd,Unit 1414, Houston, TX 77030 USA.
EM wenliliu@mdanderson.org
RI Qdaisat, Aiham/AAF-8763-2021; Yeung, Sai-Ching/AAI-6178-2021; liu,
   wenli/JRW-0517-2023; Bruera, Eduardo/AAA-1550-2022; Underwood,
   Susan/Z-4897-2019
OI Qdaisat, Aiham/0000-0003-0063-8461; Yeung,
   Sai-Ching/0000-0001-5170-0822; Guo, Ying/0000-0002-3715-4287; 
FU NIH through Cancer Center Support Grant [P30 CA016672]; Duncan Family
   Institute for Cancer Prevention and Risk Assessment; Richard E. Haynes
   Distinguished Professorship for Clinical Cancer Prevention at The
   University of Texas MD Anderson Cancer Center; National Cancer Institute
   [P30CA016672] Funding Source: NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   University of Texas MD Anderson Cancer Center is supported in part by
   the NIH through Cancer Center Support Grant P30 CA016672. The research
   was funded in part through the support of the Duncan Family Institute
   for Cancer Prevention and Risk Assessment and the Richard E. Haynes
   Distinguished Professorship for Clinical Cancer Prevention at The
   University of Texas MD Anderson Cancer Center (L. Cohen).
CR [Anonymous], 2013, TRADITIONAL MED STRA
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NR 20
TC 11
Z9 11
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2020
VL 19
AR 1534735420928490
DI 10.1177/1534735420928490
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA LY8KB
UT WOS:000540776000001
PM 32508209
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jang, A
   Brown, C
   Lamoury, G
   Morgia, M
   Boyle, F
   Marr, I
   Clarke, S
   Back, M
   Oh, B
AF Jang, Andrew
   Brown, Chris
   Lamoury, Gillian
   Morgia, Marita
   Boyle, Frances
   Marr, Isobel
   Clarke, Stephen
   Back, Michael
   Oh, Byeongsang
TI The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic
   Review and Meta-Analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture; cancer; fatigue; cancer related fatigue
ID BREAST-CANCER; PSYCHOLOGICAL DISTRESS; CHRONIC PAIN; MANAGEMENT;
   INTERVENTIONS; ACUPRESSURE; THERAPY; TRIAL
AB Background Several studies have identified fatigue as one of the major symptoms experienced during and after cancer treatment. However, there are limited options to manage cancer related fatigue (CRF) with pharmacological interventions. Several acupuncture studies suggested that acupuncture has a positive impact on CRF. This review aims to assess the evidence of acupuncture for the treatment of CRF. Method Electronic database searches were conducted on 4 English databases (Medline, PubMed, Embase, and ScienceDirect). Search keywords were; "acupuncture" and "cancer," or "cancer related fatigue." Studies published as full text randomized controlled trials (RCTs) in English were included. Estimates of change in fatigue cores were pooled using a random effects meta-analysis where randomized comparisons were available for true acupuncture versus sham acupuncture and true acupuncture versus usual care. The quality of original papers were assessed using the Cochrane Collaboration's tool for assessing risk of bias (ROB). Results Nine RCTs were selected for review with a total of 809 participants and a range of 13 to 302 participants within the studies. Six RCTs reported significant improvement of CRF for the acupuncture intervention compared to the control groups. Pooled estimates suggest Brief Fatigue Inventory scores are 0.93 points lower 95% CI (-1.65, -0.20) in true acupuncture versus sham acupuncture and 2.12 points lower 95% C (-3.21, -1.04) in true acupuncture versus usual care. Six studies had low risk of bias (ROB) and 3 studies had a moderate ROB predominantly in blinding of participants, blinding of assessors and incomplete data outcomes. Among the 9 RCTs, 2 studies have reported the occurrence of minor adverse effects (spot bleeding and bruising) related to acupuncture treatment. No serious adverse reactions related to acupuncture were reported. Conclusion The current literature review suggests that acupuncture has therapeutic potential in management of CRF for cancer survivors. Promotion of acupuncture in cancer care to manage CRF may improve the quality of life of cancer survivors.
C1 [Jang, Andrew; Brown, Chris; Lamoury, Gillian; Morgia, Marita; Marr, Isobel; Clarke, Stephen; Back, Michael; Oh, Byeongsang] Royal North Shore Hosp, St Leonards, NSW, Australia.
   [Brown, Chris; Lamoury, Gillian; Boyle, Frances; Clarke, Stephen; Back, Michael; Oh, Byeongsang] Univ Sydney, Sydney, NSW, Australia.
   [Lamoury, Gillian; Morgia, Marita; Boyle, Frances; Back, Michael; Oh, Byeongsang] Mater Hosp, Sydney, NSW, Australia.
C3 Royal North Shore Hospital; University of Sydney
RP Oh, B (corresponding author), Univ Sydney, Sydney Med Sch, Sydney, NSW 2005, Australia.
EM byeong.oh@sydney.edu.au
RI ; Clarke, Stephen/HNR-3821-2023; Brown, Chris/H-2797-2019; Oh,
   Byeongsang/ABH-1460-2020
OI Back, Michael/0000-0003-2363-8333; Jang, Anew/0000-0001-6759-9327;
   Clarke, Stephen/0000-0001-5817-1222; Lamoury,
   Gillian/0000-0001-9290-0193; Oh, Byeongsang/0000-0002-7204-6716
CR [Anonymous], 2011, EVID BASED COMPLEMEN
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NR 34
TC 35
Z9 45
U1 1
U2 22
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2020
VL 19
AR 1534735420949679
DI 10.1177/1534735420949679
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA NY4VJ
UT WOS:000576388900001
PM 32996339
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huang, XR
   Xu, M
   Xu, Y
   Wang, SJ
   Ni, FL
AF Huang, Xin-Rui
   Xu, Min
   Xu, Yan
   Wang, Shu-Jie
   Ni, Fei-Lin
TI Auricular acupressure for insomnia in women with breast cancer A
   systematic review and meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE auricular acupressure; auricular point; lymphoma; non-pharmacological
   therapy; sleep disorder; systematic review; Traditional Chinese Medicine
   therapy
ID SINGLE-BLIND; ACUPUNCTURE; SLEEP; ASSOCIATION; PREVALENCE; EFFICACY;
   QUALITY; ANXIETY; PAIN
AB Background: Breast cancer as the malignant tumor with the highest incidence and mortality rate among the global female population. Insomnia is a common complaint in breast cancer patients, more than one-third (38-47%) of breast cancer patients suffer it. Auricular acupressure (AA), a non-pharmacological therapy, has been used in the studies to intervene in insomnia in breast cancer patients. The objective of this systematic review and meta-analysis is to investigate the efficacy and safety of AA therapy in intervening with insomnia in breast cancer.
   Methods: A systematic literature search was performed for 10 databases up to January of 2024 to identify randomized control trials (RCTs). The methodological quality of RCTs was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Data were screened and extracted independently using predesigned forms. The meta-analysis was conducted using RevMan 5.3 software, P-value <.05 means statistically significant.
   Results: This review included 15 studies from 3 different countries with a total of 1125 adult participants. The pooled results showed that AA significantly in improving sleep quality (mean difference [MD] = -3.36, 95% confidence interval [CI]: [-4.65, -2.07], P <.001) and life quality (MD = -7.82, 95% CI: [-14.76, -0.88], P =.03). Based on data from sleep monitoring devices, AA was valuable for improving sleep efficiency (MD = -3.63, 95% CI: [-4.19,-3.07], P =.03) in breast cancer patients. Adverse events were reported in 5 RCTs. Common adverse reactions include auricular skin allergic reaction (10/259, 3.9%), bruising (7/259, 2.7%), pain (3/259, 1.2%), and local pressure ulcers on the auricular points (2/259, 0.8%). The evidence grade was moderate because of the substantial heterogeneity among studies. Heart, Shenmen, and Subcortex were the 3 most numerous auricular points, with a total share of up to 71.70%.
   Conclusion: This systematic review and meta-analysis demonstrates the efficacy and safety of AA in intervening insomnia in breast cancer patients, providing a basis for the selection of clinical auricular points. However, the high-quality RCTs in existence are not enough, and more rigorous trials are needed to identify the efficacy of AA and insomnia.
C1 [Huang, Xin-Rui] Zhejiang Chinese Med Univ, Dept Neurol, Zhejiang Prov Hosp Chinese Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China.
   [Xu, Min] Zhejiang Chinese Med Univ, Off Dean, Zhejiang Prov Hosp Chinese Med, Affiliated Hosp 1, Dean, Hangzhou, Zhejiang, Peoples R China.
   [Xu, Yan] Zhejiang Univ Chinese Med, Coll Nursing, Hangzhou, Zhejiang, Peoples R China.
   [Wang, Shu-Jie] Zhejiang Chinese Med Univ, Dept Breast Dis, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Zhejiang, Peoples R China.
   [Ni, Fei-Lin] Zhejiang Chinese Med Univ, Dept Neurol, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University; Zhejiang Chinese
   Medical University; Zhejiang Chinese Medical University
RP Xu, M (corresponding author), Zhejiang Chinese Med Univ, Off Dean, Zhejiang Prov Hosp Chinese Med, Affiliated Hosp 1, Dean, Hangzhou, Zhejiang, Peoples R China.
EM yudi1212@163.com
OI Huang, Xinrui/0000-0001-8615-5537
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NR 52
TC 4
Z9 5
U1 6
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 14
PY 2025
VL 104
IS 7
AR e41498
DI 10.1097/MD.0000000000041498
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2YJ5N
UT WOS:001494259000101
PM 39960920
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ying, Y
   Yang, GD
   Li, XY
   Wang, FF
   Zhang, GB
AF Ying, Yi
   Yang, Guodong
   Li, Xiaoyu
   Wang, Feifei
   Zhang, Guobing
TI Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling
   pathway and microglial suppression in the chronic constriction injury
   rat model of neuropathic pain
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE electroacupuncture; EphBs; microglia; neuropathic pain; p38
   mitogen-activated protein kinase
ID SPINAL DORSAL-HORN; SYNAPTIC PLASTICITY; P38 MAPK; MECHANISMS;
   ACTIVATION; HYPERALGESIA; INFLAMMATION; ACUPUNCTURE; ALLODYNIA; RECEPTOR
AB Objective: To explore the analgesic effects of electroacupuncture (EA) and its impact on the EphBs-p38 mitogen-activated protein kinase (MAPK) pathway and microglia in a rat model of neuropathic pain (NP).Methods: Following adaptive training, 60 male Sprague Dawley (SD) rats were allocated to one of two experiments. In experiment 1, rats received intrathecal SB203580 (p38 MAPK inhibitor), intramuscular EphB1-Fc (EphBs inhibitor) or no injection before undergoing chronic constrictive injury (CCI). In experiment 2, CCI model rats received EA either alone or combined with either anisomycin (p38 MAPK agonist) or EphrinB1-Fc (EphBs agonist) versus minimal acupuncture (MA) as a control intervention. A sham surgery group was included in both experiments as a control for CCI. All groups consisted of n = 6 rats (four in experiment 1 and six in experiment 2). Behavioral hyperalgesia was examined and the spinal L5-6 region was harvested and subjected to enzyme-linked immunosorbent assay to assess tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta levels. Western blotting and immunofluorescence were used to assess protein expression of B-cell lymphoma (Bcl)-2, Bcl-2 associated X-protein (BAX), EphB1, EphrinB1, p38 MAPK, phosphorylated (p)-p38 MAPK and ionized calcium binding adaptor molecule (Iba)-1.Results: CCI induced behavioral hyperalgesia, as demonstrated by altered paw withdrawal latency (PWL), paw withdrawal threshold (PWT) and cytokine levels, and increased p38 MAPK phosphorylation and microglial activation. However, inhibitors SB203580 and EphB1-Fc reversed these effects. Notably, EA showed similar beneficial effects, but these were counteracted when combined with anisomycin and EphrinB1-Fc.Conclusions: The analgesic effects of EA in this rat model of NP appear to be linked to diminished p-p38 MAPK expression and subsequent microglial deactivation. EA has a potential role as a complementary therapy for NP.
C1 [Ying, Yi] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, XianJu Peoples Hosp, Affiliated Xianjus Hosp,Dept Tradit Chinese Med, Zhejiang Southeast Campus, Taizhou, Peoples R China.
   [Yang, Guodong] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Xianjus Hosp, XianJu Peoples Hosp,Dept Orthoped, Zhejiang Southeast Campus, Taizhou, Peoples R China.
   [Li, Xiaoyu] Zhejiang Chinese Med Univ, Sch Clin Med 3, Key Lab Acupuncture & Neurol Zhejiang Prov, Dept Neurobiol & Acupuncture Res,Sch Rehabil Med, Hangzhou, Peoples R China.
   [Wang, Feifei] Hangzhou Med Coll, XianJu Peoples Hosp, Zhejiang Prov Peoples Hosp, Affiliated Xianjus Hosp,Dept Rehabil, Zhejiang Southeast Campus, Taizhou, Peoples R China.
   [Zhang, Guobing] Zhejiang Hosp Integrated Tradit Chinese & Western, Dept Pharm, Hangzhou 310014, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Zhejiang Chinese Medical University; Hangzhou Medical College; Zhejiang
   Provincial People's Hospital
RP Zhang, GB (corresponding author), Zhejiang Hosp Integrated Tradit Chinese & Western, Dept Pharm, Hangzhou 310014, Peoples R China.
EM 13675851802@163.com
RI 王, 菲菲/R-1936-2019; 李, 晓羽/IUQ-0607-2023; Yang, Guodong/KXQ-8051-2024
FU Zhejiang Province Traditional Chinese Medicine Science and Technology
   Plan Project [2021ZA145]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the Zhejiang Province Traditional Chinese Medicine Science
   and Technology Plan Project [grant no. 2021ZA145].
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NR 42
TC 0
Z9 0
U1 2
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD OCT
PY 2025
VL 43
IS 5
BP 278
EP 289
DI 10.1177/09645284251363987
EA AUG 2025
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 8IX9P
UT WOS:001555278700001
PM 40847801
DA 2026-01-16
ER

PT J
AU Tao, WW
   Jiang, H
   Tao, XM
   Jiang, P
   Sha, LY
   Sun, XC
AF Tao, Wei-Wei
   Jiang, Hua
   Tao, Xiao-Mei
   Jiang, Ping
   Sha, Li-Yan
   Sun, Xian-Ce
TI Effects of Acupuncture, Tuina, Tai Chi, Qigong, and Traditional Chinese
   Medicine Five-Element Music Therapy on Symptom Management and Quality of
   Life for Cancer Patients: A Meta-Analysis
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Article
DE Acupuncture; massage; Tai Chi; Qigong; cancer; symptom management;
   meta-analysis
ID BREAST-CANCER; CONTROLLED-TRIAL; POSTOPERATIVE ILEUS; CARE; WOMEN;
   ELECTROACUPUNCTURE; INTERVENTIONS; SURVIVORS; FATIGUE; MOXIBUSTION
AB Context. Most cancer patients suffer from both the disease itself and symptoms induced by conventional treatment. Available literature on the clinical effects on cancer patients of acupuncture, Tuina, Tai Chi, Qigong, and Traditional Chinese Medicine Five-Element Music Therapy (TCM-FEMT) reports controversial results.
   Objectives. The primary objective of this meta-analysis was to evaluate the effect of acupuncture, Tuina, Tai Chi, Qigong, and TCM-FEMT on various symptoms and quality of life (QOL) in patients with cancer; risk of bias for the selected trials also was assessed.
   Methods. Studies were identified by searching electronic databases (MEDLINE via both PubMed and Ovid, Cochrane Central, China National Knowledge Infrastructure, Chinese Scientific Journal Database, China Biology Medicine, and Wanfang Database). All randomized controlled trials (RCTs) using acupuncture, Tuina, Tai Chi, Qigong, or TCM-FEMT published before October 2, 2014, were selected, regardless of whether the article was published in Chinese or English.
   Results. We identified 67 RCTs (5465 patients) that met our inclusion criteria to perform this meta-analysis. Analysis results showed that a significant combined effect was observed for QOL change in patients with terminal cancer in favor of acupuncture and Tuina (Cohen's d: 0.21-4.55, P < 0.05), whereas Tai Chi and Qigong had no effect on QOL of breast cancer survivors (P > 0.05). The meta-analysis also demonstrated that acupuncture produced small-to-large effects on adverse symptoms including pain, fatigue, sleep disturbance, and some gastrointestinal discomfort; however, no significant effect was found on the frequency of hot flashes (Cohen's d = -0.02; 95% CI = -1.49 to 1.45; P = 0.97; I-2 = 36%) and mood distress (P > 0.05). Tuina relieved gastrointestinal discomfort. TCM-FEMT lowered depression level. Tai Chi improved vital capacity of breast cancer patients. High risk of bias was present in 74.63% of the selected RCTs. Major sources of risk of bias were lack of blinding, allocation concealment, and incomplete outcome data.
   Conclusion. Taken together, although there are some clear limitations regarding the body of research reviewed in this study, a tentative conclusion can be reached that acupuncture, Tuina, Tai Chi, Qigong, or TCM-FEMT represent beneficial adjunctive therapies. Future study reporting in this field should be improved regarding both method and content of interventions and research methods. (c) 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Tao, Wei-Wei; Sha, Li-Yan] Dalian Med Univ, Coll Nursing, 9 West Sect,Lvshun South Rd, Dalian, Peoples R China.
   [Jiang, Ping] Dalian Med Univ, Grad Sch, Dalian, Peoples R China.
   [Sun, Xian-Ce] Dalian Med Univ, Coll Publ Hlth, Dalian, Peoples R China.
   [Jiang, Hua] Peking Univ, Sch Nursing, Beijing 100871, Peoples R China.
   [Tao, Xiao-Mei] Beijing Shijitan Hosp, Beijing, Peoples R China.
C3 Dalian Medical University; Dalian Medical University; Dalian Medical
   University; Peking University
RP Tao, WW (corresponding author), Dalian Med Univ, Coll Nursing, 9 West Sect,Lvshun South Rd, Dalian, Peoples R China.; Jiang, P (corresponding author), Dalian Med Univ, Grad Sch, Dalian, Peoples R China.
EM taoweiwei2003@163.com; dywx.2009@163.com
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NR 107
TC 160
Z9 194
U1 7
U2 239
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD APR
PY 2016
VL 51
IS 4
BP 728
EP 747
DI 10.1016/j.jpainsymman.2015.11.027
PG 20
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA DK1FK
UT WOS:000374657700012
PM 26880252
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhang, YZ
   Sun, Y
   Li, DM
   Liu, XY
   Fang, C
   Yang, CM
   Luo, TY
   Lu, H
   Li, HC
   Zhang, HY
   Liang, QY
   Wu, JH
   Huang, LM
   Xu, R
   Ren, LP
   Chen, QJ
AF Zhang, Yuzhu
   Sun, Yang
   Li, Dongmei
   Liu, Xiaoyuan
   Fang, Chen
   Yang, Chunmin
   Luo, Tianyu
   Lu, Hai
   Li, Huachao
   Zhang, Hongyan
   Liang, Qianyi
   Wu, Jiahua
   Huang, Limei
   Xu, Rui
   Ren, Liping
   Chen, Qianjun
TI Acupuncture for Breast Cancer: A Systematic Review and Meta-Analysis of
   Patient-Reported Outcomes
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE acupuncture; patient-reported outcome; breast cancer; systematic review;
   meta-analysis
ID MENOPAUSAL HOT FLASHES; CONTROLLED-TRIAL; VASOMOTOR SYMPTOMS;
   DOUBLE-BLIND; DUAL-CENTER; WOMEN; ELECTROACUPUNCTURE; FATIGUE; THERAPY;
   ARTHRALGIA
AB The present systematic review and meta-analysis was undertaken to evaluate the effects of acupuncture in women with breast cancer (BC), focusing on patient-reported outcomes (PROs). Methods A comprehensive literature search was carried out for randomized controlled trials (RCTs) reporting PROs in BC patients with treatment-related symptoms after undergoing acupuncture for at least four weeks. Literature screening, data extraction, and risk bias assessment were independently carried out by two researchers. Results Out of the 2, 524 identified studies, 29 studies representing 33 articles were included in this meta-analysis. At the end of treatment (EOT), the acupuncture patients' quality of life (QoL) was measured by the QLQ-C30 QoL subscale, the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES), the Functional Assessment of Cancer Therapy-General/Breast (FACT-G/B), and the Menopause-Specific Quality of Life Questionnaire (MENQOL), which depicted a significant improvement. The use of acupuncture in BC patients lead to a considerable reduction in the scores of all subscales of the Brief Pain Inventory-Short Form (BPI-SF) and Visual Analog Scale (VAS) measuring pain. Moreover, patients treated with acupuncture were more likely to experience improvements in hot flashes scores, fatigue, sleep disturbance, and anxiety compared to those in the control group, while the improvements in depression were comparable across both groups. Long-term follow-up results were similar to the EOT results. Conclusions Current evidence suggests that acupuncture might improve BC treatment-related symptoms measured with PROs including QoL, pain, fatigue, hot flashes, sleep disturbance and anxiety. However, a number of included studies report limited amounts of certain subgroup settings, thus more rigorous, well-designed and larger RCTs are needed to confirm our results.
C1 [Zhang, Yuzhu; Sun, Yang; Liu, Xiaoyuan; Fang, Chen; Yang, Chunmin; Luo, Tianyu; Lu, Hai; Li, Huachao; Zhang, Hongyan; Liang, Qianyi; Wu, Jiahua; Huang, Limei; Xu, Rui; Ren, Liping; Chen, Qianjun] Guangdong Prov Hosp Chinese Med, Breast Clin Ctr, Guangzhou, Peoples R China.
   [Zhang, Yuzhu; Sun, Yang; Liu, Xiaoyuan; Fang, Chen; Yang, Chunmin; Luo, Tianyu; Lu, Hai; Li, Huachao; Zhang, Hongyan; Liang, Qianyi; Wu, Jiahua; Huang, Limei; Xu, Rui; Ren, Liping; Chen, Qianjun] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Breast Clin Ctr, Guangzhou, Peoples R China.
   [Zhang, Yuzhu] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing, Peoples R China.
   [Li, Dongmei] Zhuhai Hosp Guangdong Prov Hosp Chinese Med, Breast Dept, Zhuhai, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; National Resource Center for Chinese Materia Medica,
   CACMS; China Academy of Chinese Medical Sciences
RP Xu, R; Ren, LP; Chen, QJ (corresponding author), Guangdong Prov Hosp Chinese Med, Breast Clin Ctr, Guangzhou, Peoples R China.; Xu, R; Ren, LP; Chen, QJ (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Breast Clin Ctr, Guangzhou, Peoples R China.
EM catdoctor007@163.com; mastcell@aliyun.com; cqj55@163.com
RI Zhang, Yuzhu/HJP-7447-2023; Huang, Limei/LWI-0738-2024
FU National Natural Science Foundation of China [81904206, 81974571];
   Guangdong Natural Science Foundation [2017A030313719]; Foundation
   Project of Guangzhou University of Traditional Chinese Medicine
   [XKP2019002]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81904206 and 81974571), Guangdong Natural
   Science Foundation (No. 2017A030313719), and Foundation Project of
   Guangzhou University of Traditional Chinese Medicine (No. XKP2019002).
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NR 55
TC 36
Z9 45
U1 1
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUN 10
PY 2021
VL 11
AR 646315
DI 10.3389/fonc.2021.646315
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SX1LO
UT WOS:000664973500001
PM 34178633
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Choi, J
   Jeon, C
   Lee, JH
   Jang, JU
   Quan, FS
   Lee, K
   Kim, W
   Kim, SK
AF Choi, Jiho
   Jeon, Changhoon
   Lee, Ji Hwan
   Jang, Jo Ung
   Quan, Fu Shi
   Lee, Kyungjin
   Kim, Woojin
   Kim, Sun Kwang
TI Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced
   Neuropathic Pain in Rats: Mediation by Spinal α2-Adrenergic
   Receptor
SO TOXINS
LA English
DT Article
DE bee venom acupuncture; chemotherapy-induced neuropathic pain; paclitaxel
ID COMPLETE FREUNDS-ADJUVANT; PERIPHERAL NEUROPATHY; ACUPOINT STIMULATION;
   CONTROLLED-TRIAL; COLD ALLODYNIA; FORMALIN TEST; MODEL; APIPUNCTURE;
   ELECTROACUPUNCTURE; CHEMOTHERAPY
AB Paclitaxel, a chemotherapy drug for solid tumors, induces peripheral painful neuropathy. Bee venom acupuncture (BVA) has been reported to have potent analgesic effects, which are known to be mediated by activation of spinal -adrenergic receptor. Here, we investigated the effect of BVA on mechanical hyperalgesia and spinal neuronal hyperexcitation induced by paclitaxel. The role of spinal -adrenergic receptor subtypes in the analgesic effect of BVA was also observed. Administration of paclitaxel (total 8 mg/kg, intraperitoneal) on four alternate days (days 0, 2, 4, and 6) induced significant mechanical hyperalgesic signs, measured using a von Frey filament. BVA (1 mg/kg, ST36) relieved this mechanical hyperalgesia for at least two hours, and suppressed the hyperexcitation in spinal wide dynamic range neurons evoked by press or pinch stimulation. Both melittin (0.5 mg/kg, ST36) and phospholipase A2 (0.12 mg/kg, ST36) were shown to play an important part in this analgesic effect of the BVA, as they significantly attenuated the pain. Intrathecal pretreatment with the (2)-adrenergic receptor antagonist (idazoxan, 50 mu g), but not (1)-adrenergic receptor antagonist (prazosin, 30 mu g), blocked the analgesic effect of BVA. These results suggest that BVA has potent suppressive effects against paclitaxel-induced neuropathic pain, which were mediated by spinal (2)-adrenergic receptor.
C1 [Choi, Jiho; Jeon, Changhoon; Kim, Woojin; Kim, Sun Kwang] Kyung Hee Univ, Coll Korean Med, Dept Physiol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Lee, Ji Hwan; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Jang, Jo Ung; Kim, Woojin; Kim, Sun Kwang] Kyung Hee Univ, Grad Sch, Dept East West Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Quan, Fu Shi] Kyung Hee Univ, Sch Med, Dept Med Zool, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Lee, Kyungjin] Kyung Hee Univ, Coll Korean Med, Dept Herbol, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University; Kyung Hee University
RP Kim, W; Kim, SK (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Physiol, 26 Kyungheedae Ro, Seoul 02447, South Korea.; Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.; Kim, W; Kim, SK (corresponding author), Kyung Hee Univ, Grad Sch, Dept East West Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM cyanical@hotmail.com; cjmystars44@gmail.com; mibdna@khu.ac.kr;
   powerfox032@naver.com; fsquan@khu.ac.kr; niceday@khu.ac.kr;
   wjkim@khu.ac.kr; skkim77@khu.ac.kr
RI Kim, Sun Kwang/AAM-1289-2020; Kim, Woojin/AAK-2464-2020; Quan,
   Fu-Shi/V-1826-2019
OI Kim, Sun Kwang/0000-0002-2649-6652; Lee, Ji Hwan/0000-0001-9572-6864; 
FU Korea Institute of Oriental Medicine [Y16113]; Kyung Hee University
   College of Korean Medicine; society of immune and pain
FX This work was supported by an undergraduate research program (URP) grant
   from the Korea Institute of Oriental Medicine (Y16113) and an URP grant
   from Kyung Hee University College of Korean Medicine, and by a grant
   from the society of immune and pain.
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   Lee MS, 2008, J PAIN, V9, P289, DOI 10.1016/j.jpain.2007.11.012
   Li D, 2015, TOXINS, V7, P2422, DOI 10.3390/toxins7072422
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NR 48
TC 40
Z9 42
U1 1
U2 13
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD NOV
PY 2017
VL 9
IS 11
AR 351
DI 10.3390/toxins9110351
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FO2FI
UT WOS:000416589800016
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yu, RF
   Guo, XF
   Zhu, YJ
   Chen, Y
   Zhang, CY
   Chai, XS
   Wang, YQ
AF Yu, Ruifang
   Guo, Xinfeng
   Zhu, Yanjuan
   Chen, Yue
   Zhang, Canyang
   Chai, Xiaoshu
   Wang, Yingqi
TI Acupuncture reduced incidence of insomnia symptoms in patients with lung
   cancer: a retrospective cohort study
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Insomnia symptoms; Lung cancer; Prevention; Acupuncture
ID BREAST-CANCER; SLEEP QUALITY; ELECTROACUPUNCTURE; FATIGUE; PREVALENCE;
   PREVENTION; EFFICACY; ADULTS
AB Purpose About 30-50% of lung cancer patients suffer from insomnia with limited prevention options. We conducted a retrospective cohort study to investigate whether acupuncture for cancer-related symptoms such as pain could reduce the incidence of insomnia symptoms. Methods We included newly diagnosed lung cancer patients without prior insomnia symptoms from Guangdong Provincial Hospital of Chinese Medicine (2012-2021) and followed up until January 31, 2022. Cases were propensity score-matched by sex, age, ECOG PS score, pathological diagnosis, therapy, and comorbidities. The main outcome was the incidence of insomnia symptoms, identified by psychiatric diagnosis or insomnia symptoms in medical records. Results Among 1295 lung cancer survivors, 918 patients were matched (459 per group). Over an average follow-up of 218.6 days, insomnia symptoms were observed in 20.9% of the acupuncture group and 42.2% of the non-acupuncture group. Acupuncture was linked to a lower incidence of insomnia symptoms (adjusted HR 0.31, 95% CI 0.23-0.39). Higher frequency and more numerous acupuncture sessions further reduced the risk of insomnia symptoms (adjusted HR 0.15 for frequency of 1 day/session, adjusted HR 0.15 for sessions > 16). The acupuncture group had a significantly lower cumulative incidence of insomnia (log-rank test, P < 0.01). Conclusion Our results suggest that acupuncture may prevent the incidence of insomnia symptoms in patients with lung cancer. Daily sessions and a cumulative total of 16 or more treatments may enhance the benefit.
C1 [Yu, Ruifang; Zhang, Canyang] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China.
   [Yu, Ruifang; Guo, Xinfeng; Zhang, Canyang] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Guo, Xinfeng] Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.
   [Guo, Xinfeng] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
   [Zhu, Yanjuan; Chai, Xiaoshu] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Dept Oncol, Guangzhou, Peoples R China.
   [Chen, Yue] Guangzhou Univ Chinese Med, Coll Acu Moxi & Rehabil, Guangzhou, Peoples R China.
   [Wang, Yingqi] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine
RP Chai, XS (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Dept Oncol, Guangzhou, Peoples R China.; Wang, YQ (corresponding author), Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.
EM chaixiaoshu@126.com; wyq950101@126.com
FU the State Key Laboratory of Dampness Syndrome of Chinese Medicine, The
   Second Affiliated Hospital of Guangzhou University of Chinese Medicine
   [No. SZ2021ZZ0401]; Science and Technology Planning Project of Guangdong
   Province [No. 2023B1212060063]; Fuding for Young Top Talents of
   Guangzhou University of Chinese Medicines [A1-2601-25-415-111Z68];
   Fuding for Young Top Talents of Guangdong Provincial Hospital of
   Traditional Chinese Medicine,International Collaborative Research
   Program of Guangdong Provincial Hospital of Traditional Chinese Medicine
   [YN2024HL05]
FX The authors declare that financial support was received for the
   publication of this article. This study was supported by Fuding for
   Young Top Talents of Guangzhou University of Chinese Medicines
   (A1-2601-25-415-111Z68), Funding for Young Top Talents of Guangdong
   Provincial Hospital of Traditional Chinese Medicine, International
   Collaborative Research Program of Guangdong Provincial Hospital of
   Traditional Chinese Medicine (YN2024HL05), the State Key Laboratory of
   Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of
   Guangzhou University of Chinese Medicine (No. SZ2021ZZ0401), and the
   Science and Technology Planning Project of Guangdong Province (No.
   2023B1212060063).
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NR 57
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD DEC 19
PY 2025
VL 34
IS 1
AR 45
DI 10.1007/s00520-025-10256-8
PG 16
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA AA6HP
UT WOS:001643600000001
PM 41417088
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Guo, J
   Pei, LX
   Chen, L
   Chen, H
   Gu, DM
   Xin, C
   Peng, YJ
   Sun, JH
AF Guo, Jing
   Pei, Lixia
   Chen, Lu
   Chen, Hao
   Gu, Dongmei
   Xin, Chen
   Peng, Yongjun
   Sun, Jianhua
TI Research Trends of Acupuncture Therapy on Cancer Over the Past Two
   Decades: A Bibliometric Analysis
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Review
DE acupuncture therapy; cancer; bibliometric analysis; CiteSpace; VOSviewer
ID INDUCED PERIPHERAL NEUROPATHY; BREAST-CANCER; AROMATASE INHIBITORS;
   PALLIATIVE CARE; HOT FLASHES; FATIGUE; ELECTROACUPUNCTURE; CHEMOTHERAPY;
   MANAGEMENT; PAIN
AB Purpose:
   Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the current status and trends in this field over the past 2 decades.
   Methods:
   Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was used for co-authorship network of countries/institutions, dual-map analysis, and detecting the keywords with citation bursts. VOSviewer was used to construct networks based on co-authorship and co-citation analysis of authors, and co-occurrence of keywords.
   Results:
   A total of 927 articles and reviews were included in the final analysis. The number of publications has steadily increased with some fluctuations among years. The country and institution contributing most to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was the most productive author and Molassiotis A ranked first in the cited authors. The co-occurrence analysis revealed 5 clusters (including "clinical trials," "clinical studies on chemotherapy/radiation-induced symptoms," "CAM therapy for cancer," "clinical studies on vasomotor symptoms," and "systematic reviews"). Most recent keyword bursts were "neuropathic pain," "arthralgia," "prevention," "supportive care," and "integrative medicine".
   Conclusions:
   The annual publication output would increase rapidly in the next decade, which shows a promising future in this research field. Future research hotspots would focus on the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive care, and integrative medicine.
C1 [Guo, Jing; Pei, Lixia; Chen, Lu; Gu, Dongmei; Xin, Chen; Peng, Yongjun; Sun, Jianhua] Nanjing Univ Chinese Med, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Chen, Hao] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Peng, YJ; Sun, JH (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM pengyongjun2004@126.com; 377201634@qq.com
RI ; Peng, Yongjun/F-9973-2014
OI Sun, Jianhua/0000-0002-3398-0346; 
FU State Administration of Traditional Chinese Medicine "Evidence-based
   capacity Building Project of Traditional Chinese Medicine"
   [2019XZZX-ZJ008]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the State Administration of Traditional Chinese
   Medicine "Evidence-based capacity Building Project of Traditional
   Chinese Medicine" (Reference number 2019XZZX-ZJ008).
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NR 42
TC 17
Z9 20
U1 1
U2 84
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD NOV
PY 2020
VL 19
AR 1534735420959442
DI 10.1177/1534735420959442
PG 11
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA OS8NY
UT WOS:000590416800001
PM 33143477
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU van de Castle, B
   Lukkahatai, N
   Billing, BL
   Huang, XR
   Wu, HL
   Zhang, JY
   Abdi, S
   Kameoka, J
   Smith, TJ
AF van de Castle, Barb
   Lukkahatai, Nada
   Billing, B. S. N. Lynn
   Huang, Xinran
   Wu, Hulin
   Zhang, Jingyu
   Abdi, Salahadin
   Kameoka, Jun
   Smith, Thomas J.
TI Nurse-Administered Auricular Point Acupressure for Cancer-Related Pain
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE cancer-related-pain; pain; cancer; auricular acupressure; nursing
ID LOW-BACK-PAIN; MANAGEMENT; ACUPUNCTURE; DIAGNOSIS; SURVIVORS
AB Purpose: The study aimed to (1) examine the feasibility of providing a training course on auricular point acupressure (APA) for clinical oncology nurses to integrate APA into real-world nursing care settings, and (2) examine the effectiveness of APA on cancer-related pain (CRP) under usual inpatient oncology ward conditions. Methods: This was a 2-phase feasibility study. Phase 1, an in-person, 8 hour training program was provided to oncology nurses. Phase 2, a prospective and feasibility study was conducted to evaluate the integration of APA into nursing care activities to manage CRP. Oncology patients were included if their pain was rated at >= 4 on a 0 to 10 numeric rating scale in the past 24 hours. Patients received 1 APA treatment administered by the nurses and were instructed to stimulate the points for 3 days. Study outcomes (pain intensity, fatigue, and sleep disturbance), pain medication use, and APA practice were measured by a phone survey daily. Results: Ten oncology nurses received APA training in phase 1. APA had been added to the hospital's electronic health records (EHRs) as a pain treatment. In phase 2, 33 oncology patients received APA treatment with a 100% adherence rate (pressing the seeds 3 times per day, 3 minutes per time based on the suggestion). The side effects of APA were minimal (similar to 8%-12% felt tenderness on the ear). After 3 days of APA, patients reported 38% pain relief, 39% less fatigue, and 45% improvement in sleep disturbance; 24% reduced any type of pain medication use and 19% reduced opioid use (10 mg opioids using milligram morphine equivalent). The major barrier to integrating APA into routine nursing practice was time management (how to include APA in a daily workflow). Conclusion: It is feasible to provide 8-hour training to oncology nurses for mastering APA skill and then integrating APA into their daily nursing care for patients with CRP. Based on the promising findings (decreased pain, improved fatigue and sleep disturbance, and less opioid use), the next step is to conduct a randomized clinical trial with a larger sample to confirm the efficacy of APA for oncology nurses to treat CRP in real-world practice.
C1 [van de Castle, Barb] Univ Maryland, Sch Nursing, Baltimore, MD USA.
   [Lukkahatai, Nada; Zhang, Jingyu] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   [Billing, B. S. N. Lynn] Johns Hopkins Univ Hosp, Baltimore, MD USA.
   [Huang, Xinran; Wu, Hulin] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX USA.
   [Abdi, Salahadin] Univ Texas MD Anderson Canc Ctr, Houston, TX USA.
   [Kameoka, Jun] Waseda Univ, Tokyo, Japan.
   [Smith, Thomas J.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Lukkahatai, Nada] Johns Hopkins Univ, Sch Nursing, 525 North Wolfe St, Baltimore, MD 21205 USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins University; Johns Hopkins Medicine;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; University of Texas
   System; UTMD Anderson Cancer Center; Waseda University; Johns Hopkins
   University; Johns Hopkins University
RP Lukkahatai, N (corresponding author), Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.; Lukkahatai, N (corresponding author), Johns Hopkins Univ, Sch Nursing, 525 North Wolfe St, Baltimore, MD 21205 USA.
EM nada.lukkahatai@jhu.edu
RI Huang, Xinran/KFB-7757-2024; Smith, Thomas/K-9086-2013; Lukkahatai,
   Nada/GQA-9711-2022
OI Huang, Xinran/0000-0002-8126-9735; Lukkahatai, Nada/0000-0003-3820-1812
FU Research reported in this publication was supported by the Brager
   Humanitarian Award at the Johns Hopkins Kimmel Cancer Center and an
   Under Armour Women's Health amp;amp; Breast Cancer Innovation Grant,
   Johns Hopkins Medicine. Funding sources were not inv; Brager
   Humanitarian Award at the Johns Hopkins Kimmel Cancer Center and an
   Under Armour Women's Health amp;amp; Breast Cancer Innovation Grant;
   Johns Hopkins Medicine
FX Research reported in this publication was supported by the Brager
   Humanitarian Award at the Johns Hopkins Kimmel Cancer Center and an
   Under Armour Women's Health & amp; Breast Cancer Innovation Grant, Johns
   Hopkins Medicine. Funding sources were not involved in the preparation,
   writing, or submission of this paper. It is with heavy hearts and
   profound sadness that we acknowledge the untimely passing of our
   esteemed coauthor, Professor Dr. Chao Hsing Yeh. Tragically, Dr. Yeh
   passed away during the final stages of manuscript submission, leaving an
   immeasurable void in our hearts and in the scientific community.
   Throughout the course of this project, Dr.Yeh demonstrated an
   exceptional commitment to excellence, pushing the boundaries of our
   understanding and challenging us to achieve new heights. Her insightful
   perspectives, innovative ideas, and meticulous attention to detail
   significantly enhanced the quality of this work. The authors would like
   to thank the following nurses for their work on this project: Kristen
   Hains, Steve Rutkowski, Hanna Bare, Melanie Cohen, Zoe Gearing, Kyong
   Golden, James Gonzales, Christina Lai, Brynn Puller, Wendy Wen.
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NR 42
TC 7
Z9 8
U1 1
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2023
VL 22
AR 15347354231198086
DI 10.1177/15347354231198086
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA R8ZK1
UT WOS:001067179400001
PM 37706457
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lu, LY
   Huang, XH
   Liu, C
   Wang, XY
   Lv, JQ
AF Lu, Lingyun
   Huang, Xianhao
   Liu, Ci
   Wang, Xiaoyu
   Lv, Jianqin
TI Perioperative intradermal acupuncture reduces postoperative nausea and
   vomiting after cerebellopontine angle tumor resection: a randomized
   clinical trial including mechanistic insights
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE intradermal acupuncture; metabolomics; PC6; postoperative nausea and
   vomiting; randomized controlled trial
ID HEART-RATE-VARIABILITY; CONSENSUS GUIDELINES; MASS-SPECTROMETRY;
   MANAGEMENT; ELECTROACUPUNCTURE; MODULATION
AB Background: The aim of this study was to evaluate the impact of intradermal acupuncture (IA) at PC6 on postoperative nausea and vomiting (PONV) following cerebellopontine angle tumor resection, and to investigate possible mechanisms of action.Methods: Seventy patients scheduled for elective craniotomy were randomized into IA or sham IA (Sham) groups, with interventions applied 1 h before surgery and continued for 24 h postoperatively. Co-primary outcomes were the incidence of vomiting at 0-6 h and 6-24 h post-surgery. Secondary outcomes included the incidence of nausea and pain intensity. Electrogastrography (EGG) and heart rate variability (HRV) were used to assess gastric activity and autonomic nerve function, respectively. Untargeted metabolomic analysis of serum and cerebrospinal fluid (CSF) was also performed.Results: The incidence of vomiting at 6-24 h (but not 0-6 h) post-surgery was significantly lower in the IA group (12.1%) compared to the Sham group (36.4%; p = 0.022). IA significantly reduced the incidence of nausea at 0-6 h (48.5% vs 78.8%; p = 0.011) but not 6-24 h. HRV analysis showed a higher HF component in the IA group post-surgery. Metabolomic analyses revealed significant changes in multiple metabolites and pathways in serum and CSF.Conclusion: IA stimulation at PC6 effectively reduced postoperative vomiting at 6-24 h following cerebellopontine angle tumor resection and may also reduce early nausea (at 0-6 h). The mechanisms of action underlying these effects potentially include modulation of vagus nerve activity and regulation of metabolic pathways.Trial registration number: ChiCTR2100049992 (Chinese Clinical Trial Registry)
C1 [Lu, Lingyun; Huang, Xianhao; Liu, Ci; Lv, Jianqin] Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, Div Internal Med, Chengdu 610041, Sichuan, Peoples R China.
   [Wang, Xiaoyu] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Lv, JQ (corresponding author), Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, Div Internal Med, Chengdu 610041, Sichuan, Peoples R China.
EM lvjianqin@wchscu.cn
OI Lv, Jian-qin/0000-0002-3760-2967
FU National Outstanding Youth Science Fund Project of National Natural
   Science Foundation of China [82304958]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This work was
   supported by the National Natural Science Youth Fund (grant no.
   82304958).
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD DEC
PY 2025
VL 43
IS 6
BP 330
EP 343
DI 10.1177/09645284251399690
EA NOV 2025
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA P8173
UT WOS:001626105400001
PM 41310932
DA 2026-01-16
ER

PT J
AU Zhang, YX
   Wu, BQ
   Qin, P
   Cheng, YP
   Chen, YY
AF Zhang, Yuxing
   Wu, Bangqi
   Qin, Peng
   Cheng, Yupei
   Chen, Yuyan
TI Alternative therapies in chronic non-cancer pain management: A scoping
   review of randomized controlled trials
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Chronic non-cancer pain; Complementary therapies; Pain management;
   Scoping review; Personalized treatment. Non-pharmacological; therapy
ID LOW-BACK-PAIN; CHRONIC NECK PAIN; ELECTRICAL NERVE-STIMULATION;
   CONNECTIVE-TISSUE MASSAGE; TENSION-TYPE HEADACHE; QUALITY-OF-LIFE;
   MINDFULNESS MEDITATION; CONTROLLED PILOT; MANUAL THERAPY; PRESSURE PAIN
AB Background: Chronic pain is one of the most challenging health problems in modern society, placing significant burdens on individuals and healthcare systems. While pharmacological treatments remain the primary approach to pain management, their limitations often restrict choices for both clinicians and patients. In contrast, complementary therapies are gaining recognition for their potential effectiveness and safety. However, the current literature lacks a comprehensive summary of the role of complementary therapies in chronic pain management. Objective: This review aims to summarize the complementary therapies used in chronic non-cancer pain management, assess their practical applications, identify research gaps and limitations, and provide a comprehensive perspective for the development of chronic non-cancer pain management and personalized pain management strategies. Methods: This scoping review followed the PRISMA-ScR guidelines. Randomized controlled trials (RCTs) pub- lished in the last decade were retrieved from PubMed and Web of Science using the keywords "chronic pain" and "complementary therapy." Non-English studies were excluded. Results: A total of 848 RCTs were identified, of which 128 met the inclusion criteria. The included studies addressed chronic musculoskeletal pain (102 studies), chronic visceral pain (5 studies), chronic neuropathic pain (7 studies), and 13 studies that did not specify the pain type. The complementary therapies investigated included acupuncture, manual therapy, exercise therapy, psychological interventions, mind-body therapies, and physical modalities. Conclusion: This review provides preliminary evidence supporting the efficacy and safety of complementary therapies in the management of chronic non-cancer pain. However, methodological and quality-related limita- tions were identified in the included studies. Future high-quality RCTs are needed to validate the long-term efficacy of these therapies, explore their mechanisms of action, and provide stronger evidence for their clin- ical application. Registration: This scoping review is registered on the Open Science Framework (OSF) under the following DOI: https://doi.org/10.17605/OSF.IO/67K32.
C1 [Zhang, Yuxing; Wu, Bangqi; Qin, Peng; Cheng, Yupei; Chen, Yuyan] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, 88 Changling Rd, Tianjin 300381, Peoples R China.
   [Zhang, Yuxing; Cheng, Yupei; Chen, Yuyan] Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Wu, Bangqi] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.
   [Wu, Bangqi] 88 Changling Rd, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Wu, BQ (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, 88 Changling Rd, Tianjin 300381, Peoples R China.; Wu, BQ (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China.; Wu, BQ (corresponding author), 88 Changling Rd, Tianjin, Peoples R China.
EM wbqwbq1980@outlook.com
RI Cheng, Yupei/KHZ-7192-2024
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NR 144
TC 1
Z9 1
U1 13
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2025
VL 90
AR 103154
DI 10.1016/j.ctim.2025.103154
EA MAR 2025
PG 19
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0JS5H
UT WOS:001449007800001
PM 40081508
OA gold
DA 2026-01-16
ER

PT J
AU Rehberg, B
AF Rehberg, Benno
TI Evidence-based integrative pain medicine
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Pain; Evidence-based practice; Placebo; Cancer pain; Neuropathic pain;
   Low back pain; Fibromyalgia; Integrative medicine
ID LOW-BACK-PAIN; ALTERNATIVE MEDICINE; INTERVENTIONAL THERAPIES;
   COMPLEMENTARY THERAPIES; FIBROMYALGIA; ACUPUNCTURE; GUIDELINES;
   STIMULATION; MANAGEMENT; SURGERY
AB Integrative medicine is already, consciously or unconsciously, widely practised in pain medicine. However, a large part of practised pain medicine is not evidence-based.
   In this article, the evidence for different forms of conventional pain therapy (pharmacological, psychological, physical and interventional) as well as CAM for the pain conditions cancer pain, neuropathic pain, low back pain, and fibromyalgia syndrome is reviewed. The literature search comprised only randomised controlled trials (RCTs) and systematic reviews or guideline publications in which the quality of the included studies is analysed according to predefined criteria.
   Except for cancer pain, evidence is lacking for both conventional and alternative therapies, and conventional therapy is often not sufficiently efficacious. A multimodal/multidisciplinary approach seems appropriate and integration of CAM in this approach is facilitated by the similarity of the bio-psycho-social model of chronic pain with the mind-body models of many forms of CAM. In addition, placebo-controlled studies may not be always necessary due to the fact that the placebo effect is also therapeutic in pain therapy ("therabo"). Instead, different forms of therapy may be directly compared in RCTs, accompanied by cost-effectiveness and cost-utility studies. However, pain therapy is still a long way from having an evidence-based therapy option for every patient. (C) 2010 Elsevier GmbH. All rights reserved.
C1 [Rehberg, Benno] Charite, Dept Anesthesiol CCM CVK, D-10117 Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Rehberg, B (corresponding author), Hop Univ Geneve, Dept APSIC, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM benno.rehberg-klug@hcuge.ch
RI Rehberg, Benno/AAF-3897-2019
OI Rehberg, Benno/0000-0002-3145-1555
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NR 43
TC 5
Z9 7
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD SEP
PY 2010
VL 2
IS 3
BP 109
EP 113
DI 10.1016/j.eujim.2010.06.001
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 708EW
UT WOS:000286346000002
DA 2026-01-16
ER

PT J
AU Deng, G
   Giralt, S
   Chung, DJ
   Landau, H
   Siman, J
   Search, B
   Coleton, M
   Vertosick, E
   Shapiro, N
   Chien, C
   Wang, XS
   Cassileth, B
   Mao, JJ
AF Deng, Gary
   Giralt, Sergio
   Chung, David J.
   Landau, Heather
   Siman, Jonathan
   Search, Benjamin
   Coleton, Marci
   Vertosick, Emily
   Shapiro, Nathan
   Chien, Christine
   Wang, Xin S.
   Cassileth, Barrie
   Mao, Jun J.
TI Acupuncture for reduction of symptom burden in multiple myeloma patients
   undergoing autologous hematopoietic stem cell transplantation: a
   randomized sham-controlled trial
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Acupuncture; Multiple myeloma; Hematopoietic stem cell transplantation;
   Symptom management; Complementary therapies; Integrative medicine
ID CHEMOTHERAPY-INDUCED NAUSEA; QUALITY-OF-LIFE; CANCER-PATIENTS;
   ORAL-SURGERY; EFFICACY; PAIN; ELECTROACUPUNCTURE; DISTRESS
AB Hematopoietic stem cell transplantation (HCT) is potentially curative for a number of hematologic malignancies, but is associated with high symptom burden. We conducted a randomized sham-controlled trial (RCT) to evaluate efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during HCT.
   Adult patients with multiple myeloma undergoing high-dose melphalan followed by autologous HCT (AHCT) were randomized to receive either true or sham acupuncture once daily for 5 days starting the day after chemotherapy. Patients and clinical evaluators, but not acupuncturists, were blinded to group assignment. Symptom burden, the primary outcome was assessed with the MD Anderson Symptom Inventory (MDASI) at baseline, during transplantation, and at 15 and 30 days post transplantation.
   Among 60 participants, true acupuncture produced nonsignificant reductions in overall MDASI core symptom scores and symptom interference scores during transplantation (P = .4 and .3, respectively), at 15 days (P = .10 and .3), and at 30 days posttransplantation (P = .2 and .4) relative to sham. However, true acupuncture was significantly more efficacious in reducing nausea, lack of appetite, and drowsiness at 15 days (P = .042, .025, and .010, respectively). Patients receiving sham acupuncture were more likely to increase pain medication use posttransplantation (odds ratio 5.31, P = .017).
   Acupuncture was well tolerated with few attributable adverse events. True acupuncture may prevent escalation of symptoms including nausea, lack of appetite, and drowsiness experienced by patients undergoing AHCT, and reduce the use of pain medications. These findings need to be confirmed in a future definitive study.
   NCT01811862.
C1 [Deng, Gary; Siman, Jonathan; Search, Benjamin; Coleton, Marci; Cassileth, Barrie; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
   [Giralt, Sergio; Chung, David J.; Landau, Heather] Mem Sloan Kettering Canc Ctr, Bone Marrow Transplantat Serv, 1275 York Ave, New York, NY 10021 USA.
   [Vertosick, Emily; Shapiro, Nathan; Chien, Christine] Mem Sloan Kettering Canc Ctr, Hlth Outcomes Res Grp, 1275 York Ave, New York, NY 10021 USA.
   [Wang, Xin S.] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center; University of Texas
   System; UTMD Anderson Cancer Center
RP Deng, G (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 First Ave, New York, NY 10021 USA.
EM dengg@mskcc.org
OI Siman, Jonathan/0000-0002-5996-8935; Chung, David/0000-0003-0469-839X;
   Chien, Christine/0000-0001-8859-8761
FU Gateway for Cancer Research; MSK Integrative Medicine and Translational
   Research Grant; National Institutes of Health/National Cancer Institute
   (NIH/NCI) Cancer Center Support Grant [P30 CA008748]; AC Israel
   Foundation; Byrne Fund; National Cancer Institute [P30CA008748] Funding
   Source: NIH RePORTER
FX The study was funded by a grant from the Gateway for Cancer Research,
   and the MSK Integrative Medicine and Translational Research Grant. We
   also received support from the National Institutes of Health/National
   Cancer Institute (NIH/NCI) Cancer Center Support Grant P30 CA008748, the
   AC Israel Foundation, and the Byrne Fund.
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NR 28
TC 27
Z9 31
U1 2
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD FEB
PY 2018
VL 26
IS 2
BP 657
EP 665
DI 10.1007/s00520-017-3881-7
PG 9
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA FR8XS
UT WOS:000419358600039
PM 28920142
DA 2026-01-16
ER

PT J
AU Hua, K
   Cummings, M
   Bernatik, M
   Brinkhaus, B
   Usichenko, T
   Willich, SN
   Scheibenbogen, C
   Dietzel, J
AF Hua, Kevin
   Cummings, Mike
   Bernatik, Miriam
   Brinkhaus, Benno
   Usichenko, Taras
   Willich, Stefan N.
   Scheibenbogen, Carmen
   Dietzel, Joanna
TI Effects of Auricular Stimulation on Inflammatory Parameters: Results of
   a Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO NEUROMODULATION
LA English
DT Review
DE Auriculotherapy; ear; acupuncture; in fl ammation; meta-analysis;
   transauricular vagus nerve stimulation
ID FREQUENCY CRANIAL ELECTROSTIMULATION; REST-ACTIVITY RHYTHM;
   ELECTROTHERAPY STIMULATION; SALIVARY CORTISOL; SINGLE-BLIND; PAIN;
   ACUPRESSURE; AURICULOTHERAPY; ACUPUNCTURE; FATIGUE
AB Background: The number of randomized controlled trials (RCTs) using auricular stimulation (AS) techniques, such as trans-auricular vagus nerve stimulation, auricular electrostimulation, auricular acupuncture, and acupressure in experimental and clinical settings has increased markedly over the last three decades. This systematic review evaluates the effects of AS on biomarkers of inflammation and stress responses. Materials and Methods: The following data bases were searched: MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ISI Web of Science, and Scopus Data base. Data collection and analysis were conducted independently by two reviewers. Quality and risk assessments of the included studies were performed, and a meta-analysis of the effects of the most frequently assessed biomarkers was conducted using RevMan statistical software. Results: A total of 1122 patients and healthy volunteers from 27 RCTs were included in this systematic review; 81% of the participants were female, with a median age of 51 years. Pooled data of 18 studies showed a significant effect of AS regarding a reduction of serum C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-10. Although IL-4, IL1 beta, cortisol, substance P and calcitonin gene-related peptide, and adrenocorticotropic hormone did not show any changes, salivary amylase increased under AS. Conclusions: The influence of inflammatory cytokines seems to be mediated by AS. More research is needed to investigate the effects of AS on the immunologic system in addition to its clinical significance in high-quality RCT.
C1 [Hua, Kevin; Brinkhaus, Benno; Willich, Stefan N.; Dietzel, Joanna] Charite, Inst Social Med Epidemiol & Hlth Econ, Luisenstr 57, D-10117 Berlin, Germany.
   [Hua, Kevin; Brinkhaus, Benno; Willich, Stefan N.; Dietzel, Joanna] Free Univ Berlin, Berlin, Germany.
   [Hua, Kevin; Brinkhaus, Benno; Willich, Stefan N.; Dietzel, Joanna] Humboldt Univ, Berlin, Germany.
   [Hua, Kevin; Brinkhaus, Benno; Willich, Stefan N.; Dietzel, Joanna] Berlin Inst Hlth, Berlin, Germany.
   [Cummings, Mike] British Med Acupuncture Soc, London, England.
   [Bernatik, Miriam] Int Soc Chinese Med, Munich, Germany.
   [Usichenko, Taras] Univ Hosp Greifswald, Dept Anaesthesiol, Greifswald, Germany.
   [Usichenko, Taras] McMaster Univ, Dept Anesthesia, Hamilton, ON, Canada.
   [Scheibenbogen, Carmen] Charite, Inst Med Immunol, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; Humboldt University of Berlin; Free University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   McMaster University; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Dietzel, J (corresponding author), Charite, Inst Social Med Epidemiol & Hlth Econ, Luisenstr 57, D-10117 Berlin, Germany.
EM Joanna.Dietzel@charite.de
OI Dietzel, Joanna/0000-0003-4739-4230
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NR 59
TC 4
Z9 4
U1 6
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1094-7159
EI 1525-1403
J9 NEUROMODULATION
JI Neuromodulation
PD JUN
PY 2025
VL 28
IS 4
BP 627
EP 640
DI 10.1016/j.neurom.2024.12.007
EA JUN 2025
PG 14
WC Medicine, Research & Experimental; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Neurosciences & Neurology
GA 3UA2O
UT WOS:001508988300010
PM 39998453
DA 2026-01-16
ER

PT J
AU Reed, EN
   Landmann, J
   Oberoi, D
   Piedalue, KAL
   Faris, P
   Carlson, LE
AF Reed, Erica Nicole
   Landmann, Jessa
   Oberoi, Devesh
   Piedalue, Katherine-Ann L.
   Faris, Peter
   Carlson, Linda E.
TI Group versus Individual Acupuncture (AP) for Cancer Pain: A Randomized
   Noninferiority Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID CHRONIC NONCANCER PAIN; SLEEP QUALITY INDEX; BREAST-CANCER;
   CLINICAL-TRIALS; FUNCTIONAL ASSESSMENT; SHORTENED VERSION; SOCIAL
   SUPPORT; SYMPTOMS; THERAPY; SAMPLE
AB Background. A service delivery model using group acupuncture (AP) may be more cost-effective than individual AP in general, but there is little evidence to assess whether group AP is a comparable treatment in terms of efficacy to standard individual AP. The study aimed to compare the group to individual delivery of 6-week AP among cancer patients with pain. Methods. The study design was a randomized noninferiority trial of the individual (gold standard treatment) vs. group AP for cancer pain. The primary outcome was pain interference and severity, measured through the Brief Pain Inventory (BPI). Secondary outcomes included measures of mood, sleep, fatigue, and social support. Changes in outcomes from pre- to postintervention were examined using linear mixed effects modeling and noninferiority was inferred using a noninferiority margin, a difference of change between the two arms and 95% CIs. Pain interference was tested with a noninferiority margin of 1 on the BPI, while pain severity and secondary outcomes were compared using conventional statistical methods. Results. The trial included 74 participants randomly allocated to group (35) or individual (39) AP. The noninferiority hypothesis was supported for pain interference [& x4e8; - 1, Delta 1.03, 95% CI: 0.15-2.20] and severity [& x4e8; - 0.81, Delta 0.52, 95% CI:.33-1.38] as well as for mood [& x4e8; - 7.52, Delta 9.86, 95% CI: 0.85-18.86], sleep [& x4e8; - 1.65, Delta 2.60, 95% CI: 0.33-4.88], fatigue [& x4e8; 8.54, Delta - 15.57, 95% CI: 25.60-5.54], and social support [& x4e8;.26, Delta - 0.15, 95% CI: - 0.42-0.13], meaning that group AP was not inferior to individual AP treatment. Both arms evidenced statistically significant improvements across all symptoms before and after the intervention. Effect sizes for the group vs. individual AP on outcomes of pain, sleep, mood, and social support ranged from small to very large and were consistently larger in the group condition. The total average cost-per-person for group AP ($221.25) was almost half that of individual AP ($420). Conclusions. This is the first study to examine the noninferiority of group AP with the gold standard individual AP. Group AP was noninferior to individual AP for treating cancer pain and was superior in many health outcomes. Group AP is more cost-effective for alleviating cancer pain and should be considered for implementation trials.
C1 [Reed, Erica Nicole; Oberoi, Devesh; Piedalue, Katherine-Ann L.; Carlson, Linda E.] Univ Calgary, Cumming Sch Med, Div Psychosocial Oncol, Dept Oncol, Calgary, AB, Canada.
   [Landmann, Jessa] Vive Integrat Hlth Grp, 1889 45 St NW, Calgary, AB, Canada.
   [Faris, Peter] Univ Calgary, Alberta Hlth Serv AHS, Dept Analyt, Calgary, AB, Canada.
   [Faris, Peter] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada.
C3 University of Calgary; University of Calgary; University of Calgary
RP Carlson, LE (corresponding author), Univ Calgary, Cumming Sch Med, Div Psychosocial Oncol, Dept Oncol, Calgary, AB, Canada.
EM enreed@ucalgary.ca; jessalandmann.nd@gmail.com;
   devesh.oberoi@ucalgary.ca; klpiedal@ucalgary.ca; faris@ucalgary.ca;
   lcarlso@ucalgary.ca
RI Carlson, Linda E/AEN-5702-2022; Faris, Peter/AAJ-3436-2020
OI Carlson, Linda E/0000-0002-4411-2085; Faris, Peter/0000-0001-5208-817X
FU Enbridge Research Chair in Psychosocial Oncology - Canadian Cancer
   Society Alberta/NWT Division; Alberta Cancer Foundation
FX This study was funded by the Enbridge Research Chair in Psychosocial
   Oncology, held by LEC and co-funded by the Canadian Cancer Society
   Alberta/NWT Division and the Alberta Cancer Foundation. ER held a summer
   studentship from the Alberta Cancer Foundation during the time the study
   was conducted.
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NR 43
TC 6
Z9 7
U1 1
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD APR 13
PY 2020
VL 2020
AR 7209548
DI 10.1155/2020/7209548
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA LJ7LU
UT WOS:000530343100001
PM 32351602
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Strauss, I
   Berger, A
   Ben Moshe, S
   Arad, M
   Hochberg, U
   Gonen, T
   Tellem, R
AF Strauss, Ido
   Berger, Assaf
   Ben Moshe, Shlomit
   Arad, Michal
   Hochberg, Uri
   Gonen, Tal
   Tellem, Rotem
TI Double Anterior Stereotactic Cingulotomy for Intractable Oncological
   Pain
SO STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
LA English
DT Article
DE Cingulotomy; Cognitive function; Intractable pain; Metastatic disease;
   Oncology; Pain relief; Palliative care
ID CANCER-RELATED PAIN; PREVALENCE; PERCEPTION; SIGNATURE
AB Background: Stereotactic anterior cingulotomy has been used in the treatment of patients suffering from refractory oncological pain due to its effects on pain perception. However, the optimal targets as well as suitable candidates and outcome measures have not been well defined. We report our initial experience in the ablation of 2 cingulotomy targets on each side and the use of the Brief Pain Inventory (BPI) as a perioperative assessment tool. Methods: A retrospective review of all patients who underwent stereotactic anterior cingulotomy in our Department between November 2015 and February 2017 was performed. All patients had advanced metastatic cancer with limited prognosis and suffered from intractable oncological pain. Results: Thirteen patients (10 women and 3 men) underwent 14 cingulotomy procedures. Their mean age was 54 +/- 14 years. All patients reported substantial pain relief immediately after the operation. Out of the 6 preoperatively bedridden patients, 3 started ambulating shortly after. At the 1-month follow-up, the mean preoperative Visual Analogue Scale score decreased from 9 +/- 0.9 to 4 +/- 2.7 (p = 0.003). Mean BPI pain severity and interference scores decreased from levels of 29 +/- 4 and 55 +/- 12 to 16 +/- 12 (p = 0.028) and 37 +/- 15 (p = 0.043), respectively. During the 1- and 3-month follow-up visits, 9/11 patients (82%) and 5/7 patients (71%) available for follow-up reported substantial pain relief. No patient reported worsening of pain during the study period. Neuropsychological analyses of 6 patients showed stable cognitive functions with a mild nonsignificant decline in focused attention and executive functions. Adverse events included transient confusion or mild apathy in 5 patients (38%) lasting 1-4 weeks. Conclusions: Our initial experience indicates that double stereotactic cingulotomy is safe and effective in alleviating refractory oncological pain. (c) 2018 S. Karger AG, Basel.
C1 [Strauss, Ido; Berger, Assaf; Ben Moshe, Shlomit; Gonen, Tal] Tel Aviv Univ, Tel Aviv Med Ctr, Dept Neurosurg, Tel Aviv, Israel.
   [Arad, Michal; Tellem, Rotem] Tel Aviv Univ, Palliat Care Serv, Tel Aviv Med Ctr, Tel Aviv, Israel.
   [Hochberg, Uri] Tel Aviv Univ, Inst Pain Med, Tel Aviv Med Ctr, Tel Aviv, Israel.
   [Gonen, Tal] Tel Aviv Univ, Funct Brain Ctr, Tel Aviv Med Ctr, Tel Aviv, Israel.
   [Strauss, Ido] Tel Aviv Univ, Neuromodulat Unit, Tel Aviv Med Ctr, Div Neurosurg, Tel Aviv, Israel.
   [Strauss, Ido; Berger, Assaf; Arad, Michal; Hochberg, Uri; Gonen, Tal; Tellem, Rotem] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv University; Sackler
   Faculty of Medicine
RP Strauss, I (corresponding author), Tel Aviv Univ, Div Neurosurg, Tel Aviv Sourasky Med Ctr, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.
EM idos@tlvmc.gov.il
OI Berger, Assaf/0000-0003-1198-2807; Strauss, Ido/0000-0002-1988-9685
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   Viswanathan A, 2013, NEUROSURG FOCUS, V35, DOI 10.3171/2013.6.FOCUS13236
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NR 22
TC 32
Z9 35
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-6125
EI 1423-0372
J9 STEREOT FUNCT NEUROS
JI Stereotact. Funct. Neurosurg.
PY 2017
VL 95
IS 6
BP 400
EP 408
DI 10.1159/000484613
PG 9
WC Neurosciences; Neuroimaging; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA FX6TQ
UT WOS:000426220600006
PM 29316566
DA 2026-01-16
ER

PT J
AU Jia, RN
   Tu, JF
AF Jia, Ru-Nan
   Tu, Jian-Fei
TI Integrative Application of Traditional Chinese Medicine in
   Interventional Oncology: A Comprehensive Review
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Review
DE Acupuncture therapy; Bloodletting acupuncture therapy; Chinese medicine;
   Intradermal traditional Chinese medicine packaging; Interventional
   oncology; Wrist ankle acupuncture
ID CANCER; RADIOLOGY
AB The incidence and mortality associated with malignant tumors in China remain substantial, underscoring the critical need for effective strategies to improve quality of life and prolong survival among individuals diagnosed with cancer. Recent national healthcare policies have emphasized the importance of preserving, advancing, and incorporating traditional Chinese medicine (TCM) into clinical practice. Interventional oncology remains a cornerstone in the treatment of intermediate to advanced-stage malignancies; however, it is frequently associated with adverse drug reactions and procedure-related complications, including postoperative fever, nausea, vomiting, pain, and hepatotoxicity or nephrotoxicity. This review evaluates current evidence regarding the adjunctive application of TCM in the context of interventional oncology. Findings suggest that such integrative strategies may mitigate postoperative complications, support physiological recovery, and enhance overall well-being in patients undergoing cancer therapy. The incorporation of TCM into contemporary oncological interventions represents a potentially beneficial strategy for optimizing supportive care in cancer management.Clinical trial number Not applicable.
C1 [Jia, Ru-Nan; Tu, Jian-Fei] Lishui Cent Hosp, Dept Canc Ctr, 289 Kuocang Rd, Lishui 323000, Zhejiang, Peoples R China.
RP Tu, JF (corresponding author), Lishui Cent Hosp, Dept Canc Ctr, 289 Kuocang Rd, Lishui 323000, Zhejiang, Peoples R China.
EM tujianfeitjf@126.com
FU National Health Commission; Zhejiang Provincial Medicine and Health
   Major Science and Technology Programme Key Projects [WKJ-ZJ-1932]
FX This study was supported by a grant from National Health Commission,
   Zhejiang Provincial Medicine and Health Major Science and Technology
   Programme Key Projects (WKJ-ZJ-1932).
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD AUG
PY 2025
VL 126
IS 8
BP 1647
EP 1654
DI 10.1007/s44411-025-00262-x
EA JUL 2025
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5KW7W
UT WOS:001524605300001
OA gold
DA 2026-01-16
ER

PT J
AU Mele, C
AF Mele, Cheryl
TI Intrathecal Pain Pump for Pediatric Perverse Oncological Pain
SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
LA English
DT Editorial Material
ID MORPHINE
C1 [Mele, Cheryl] Drexel Univ, Philadelphia, PA 19104 USA.
   [Mele, Cheryl] Community Hosp & Palliat Care, Jacksonville, FL USA.
C3 Drexel University
RP Mele, C (corresponding author), Drexel Univ, Philadelphia, PA 19104 USA.
EM Cm3242@drexel.edu
CR [Anonymous], 2019, WHAT IS INTR PUMP
   Bengali R, 2014, J PEDIAT HEMATOL ONC, V36, pE162, DOI 10.1097/MPH.0b013e31828e5dca
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NR 7
TC 3
Z9 3
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0882-5963
J9 J PEDIATR NURS
JI J. Pediatr. Nurs.
PD JAN-FEB
PY 2021
VL 56
BP 99
EP 100
DI 10.1016/j.pedn.2020.10.012
EA JAN 2021
PG 2
WC Nursing; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA QB6QA
UT WOS:000614263600029
PM 33131926
DA 2026-01-16
ER

PT J
AU Santillan-Garcia, A
   Moran, JM
AF Santillan-Garcia, Azucena
   Moran, J. M.
TI Statistical Concerns About Acupressure on Pain in Cancer Patients With
   Bone Metastasis Trial
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Letter
C1 [Santillan-Garcia, Azucena] Hosp Univ Burgos, Avd Islas Baleares S-N, Burgos 09006, Spain.
   [Moran, J. M.] Univ Extremadura, Caceres, Spain.
C3 Universidad de Extremadura
RP Santillan-Garcia, A (corresponding author), Hosp Univ Burgos, Avd Islas Baleares S-N, Burgos 09006, Spain.
EM ebevidencia@gmail.com
RI Santillán-García, Azucena/AAA-1900-2020; Morán, José M/N-9636-2013
OI Santillán-García, Azucena/0000-0002-7376-4170; Morán, José
   M/0000-0002-5538-182X
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   Heavey E., 2014, Statistics for nursing: A practical approach
   Serçe S, 2018, INTEGR CANCER THER, V17, P728, DOI 10.1177/1534735418769153
NR 3
TC 2
Z9 2
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JAN 29
PY 2019
VL 18
AR 1534735419827087
DI 10.1177/1534735419827087
PG 2
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA HJ8AI
UT WOS:000457418300001
PM 30791737
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, JW
   Li, LP
   Chen, YS
AF Wu, Jing-Wen
   Li, Li-Ping
   Chen, Yin-Song
TI Effects of bottle gourd moxibustion combined with umbilical therapy for
   cancer-related incomplete bowel obstruction on inflammatory cytokine
   levels
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Cancer-induced bowel obstruction; Bottle gourd moxibustion; Umbilical
   therapy; Pain management; Inflammatory cytokines; Gastrointestinal
   recovery
ID VALIDITY; OUTCOMES
AB BACKGROUND Cancer-induced incomplete bowel obstruction presents numerous clinical challenges, notably pain management and inflammation control. Conventional therapies provide limited relief, prompting investigation into complementary approaches. This study compares the efficacy of bottle gourd moxibustion combined with umbilical therapy (BGM-UT) plus standard palliative care vs standard Western palliative care alone in symptom alleviation and inflammation reduction.AIM To compare the efficacy of BGM-UT plus standard palliative care vs standard palliative care alone in reducing inflammatory cytokine levels, alleviating symptoms, and improving gastrointestinal recovery in cancer-induced incomplete bowel obstruction.METHODS A retrospective analysis was conducted on 109 patients aged 18-75 years with cancer-induced incomplete bowel obstruction treated at the Foshan Hospital of Traditional Chinese Medicine between October 2023 and September 2024. The participants were categorized into two groups: (1) Regular group receiving standard palliative care; and (2) BGM-UT group receiving additional moxibustion therapy. The inclusion criteria included ongoing opioid use and a Karnofsky performance status score below 60. The treatments were evaluated for 3 weeks in terms of opioid consumption, gastrointestinal function recovery, brief pain inventory scores, traditional Chinese medicine symptom scores, and inflammatory cytokine levels.RESULTS Initially, the groups were demographically and clinically comparable. Post-treatment, the BGM-UT group showed significant reductions in opioid intake (P = 0.027), improved gastrointestinal recovery times, and enhanced pain management as reflected by their lower brief pain inventory scores (P < 0.05). Similarly, the improvement in traditional Chinese medicine scores was greater in the BGM-UT group than in the regular group (P < 0.05). Inflammatory markers including interleukin-6, tumor necrosis factor-alpha, and C-reactive protein decreased significantly in the BGM-UT group, indicating the superior anti-inflammatory effects of this treatment (P < 0.05).CONCLUSION The addition of BGM-UT to standard palliative care enhances pain relief, accelerates gastrointestinal recovery, and effectively reduces inflammatory cytokine levels in patients with cancer-induced incomplete bowel obstruction. This combination therapy offers a promising complementary approach to managing this challenging condition. Further prospective studies are warranted to validate these findings and explore underlying mechanisms.
C1 [Wu, Jing-Wen; Li, Li-Ping; Chen, Yin-Song] Guangzhou Univ Chinese Med, Foshan Hosp Tradit Chinese Med, Clin Med Coll 8, Dept Oncol, 6 Qinren Rd, Foshan 528000, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine
RP Li, LP (corresponding author), Guangzhou Univ Chinese Med, Foshan Hosp Tradit Chinese Med, Clin Med Coll 8, Dept Oncol, 6 Qinren Rd, Foshan 528000, Guangdong, Peoples R China.
EM 13794038664@163.com
FU Medical Research Project of Foshan Health Bureau [20240243]
FX Supported by Medical Research Project of Foshan Health Bureau in 2024,
   No. 20240243.
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 7
PY 2025
VL 31
IS 41
AR 110753
DI 10.3748/wjg.v31.i41.110753
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 9WO7T
UT WOS:001616747800001
PM 41257282
OA Green Accepted, hybrid
DA 2026-01-16
ER

PT J
AU Jia, YJ
   Li, TY
   Han, P
   Chen, Y
   Pan, LJ
   Jia, CS
AF Jia, Ye-juan
   Li, Tian-yu
   Han, Peng
   Chen, Yu
   Pan, Li-jia
   Jia, Chun-sheng
TI Effects of different courses of moxibustion treatment on intestinal
   flora and inflammation of a rat model of knee osteoarthritis
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Knee osteoarthritis; Different courses; Moxibustion treatment;
   Intestinal flora; Inflammatory cytokines
ID INTERLEUKIN-10; MICROBIOTA; ARTHRITIS; ALPHA; PAIN
AB Objective: This study was done to determine the effects of different courses of moxibustion on a rat knee osteoarthritis (KOA) model, and explore the dose-effect relationship of moxibustion on KOA from the perspectives of intestinal flora and inflammatory factors. Methods: Wistar rats were randomly divided into five groups: normal, model, moxibustion for 2 weeks, moxibustion for 4 weeks and moxibustion for 6 weeks groups (n = 5 each group). A KOA rat model was induced by monosodium iodoacetate, and moxibustion intervention was performed at the acupoints "Dubi " (ST35) and "Zusanli " (ST36), once every other day. Pathologic changes in the cartilage of rat knee joints were assessed after intervention, and fecal samples were subjected to 16S rRNA high-throughput sequencing for microbial diversity analysis. Results: Damage to the knee articular cartilage was obvious in the model group, which also had increased levels of pro-inflammatory factors, decreased levels of anti-inflammatory factors, and intestinal flora dis -orders with decreased diversity. The degree of cartilage damage in the 4 and 6 weeks of moxibustion groups was significantly improved compared with the model group. The 4 and 6 weeks of moxibustion groups also demonstrated reduced levels of interleukin-1b and tumor necrosis factor-a and increased levels of interleukin-10 (P < 0.05). Both the abundance and diversity of the intestinal flora were increased, approaching those of the normal group. Abundances of probiotics Eubacterium coprostanoligenes group and Ruminococcaceae UCG-014 increased, while that of the pathogenic bacteria Lachnospiraceae NK4A136 group decreased (P < 0.05). Although the abundance of Lachnospiraceae NK4A136 group decreased in the 2 weeks of moxibustion group compared with the model group (P < 0.05), there was no statistically significant difference in serum inflammatory factors, flora species diversity or degree of pathological damage compared with the model group. Conclusion: Moxibustion treatment led to significant improvements in the intestinal flora and inflamma -tory factors of rats with KOA. Moxibustion treatment of 4 and 6 weeks led to better outcomes than the 2-week course. Moxibustion for 4 and 6 weeks can regulate intestinal flora dysfunction with increased pro-biotics and reduced pathogenic bacteria, reduce pro-inflammatory factors and increase anti-inflammatory factors. No significant differences were seen between the effects of moxibustion for 4 weeks and 6 weeks.
   Please cite this article as: Jia YJ, Li TY, Han P, Chen Y, Pan LJ, Jia CS. Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis. J Integr Med. 2022; 20(2): 173-181. (c) 2022 The Authors. Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Jia, Ye-juan; Li, Tian-yu; Han, Peng; Chen, Yu; Pan, Li-jia; Jia, Chun-sheng] Hebei Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Shijiazhuang 050200, Hebei, Peoples R China.
C3 Hebei University of Chinese Medicine
RP Jia, CS (corresponding author), Hebei Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Shijiazhuang 050200, Hebei, Peoples R China.
EM jia7158@163.com
FU National Natural Science Foundation of China [81173342, 81473773,
   XCXZZBS2021017]
FX Funding The research was supported by the National Natural Science
   Foundation of China (No. 81173342 and 81473773) and Postgrad-uate
   Innovation Funding Project (No. XCXZZBS2021017) .
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NR 43
TC 26
Z9 34
U1 8
U2 51
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAR
PY 2022
VL 20
IS 2
BP 173
EP 181
DI 10.1016/j.joim.2022.01.004
EA MAR 2022
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0G2EJ
UT WOS:000777863400010
PM 35101368
OA hybrid
DA 2026-01-16
ER

PT J
AU Coveler, AL
   Mizrahi, J
   Eastman, BM
   Apisarnthanarax, S
   Dalal, S
   McNearney, T
   Pant, S
AF Coveler, Andrew L.
   Mizrahi, Jonathan
   Eastman, Boryana M.
   Apisarnthanarax, Smith Jim
   Dalal, Shalini
   McNearney, Terry
   Pant, Shubham
CA The Precision Promise Consortium
TI Pancreas Cancer-Associated Pain Management
SO ONCOLOGIST
LA English
DT Article
DE Pancreatic neoplasms; Pain management; Palliative care
ID CELIAC PLEXUS BLOCK; INTENSITY FOCUSED ULTRASOUND; QUALITY-OF-LIFE;
   ALTERNATIVE MEDICINE USE; RELEASE CAPSULES CREON; DOUBLE-BLIND;
   PALLIATIVE RADIOTHERAPY; OPIOID TREATMENT; CLINICAL-TRIAL;
   ELECTROACUPUNCTURE
AB Pain is highly prevalent in patients with pancreas cancer and contributes to the morbidity of the disease. Pain may be due to pancreatic enzyme insufficiency, obstruction, and/or a direct mass effect on nerves in the celiac plexus. Proper supportive care to decrease pain is an important aspect of the overall management of these patients. There are limited data specific to the management of pain caused by pancreatic cancer. Here we review the literature and offer recommendations regarding multiple modalities available to treat pain in these patients. The dissemination and adoption of these best supportive care practices can improve quantity and quality of life for patients with pancreatic cancer.
   Implications for Practice Pain management is important to improve the quality of life and survival of a patient with cancer. The pathophysiology of pain in pancreas cancer is complex and multifactorial. Despite tumor response to chemotherapy, a sizeable percentage of patients are at risk for ongoing cancer-related pain and its comorbid consequences. Accordingly, the management of pain in patients with pancreas cancer can be challenging and often requires a multifaceted approach.
C1 [Coveler, Andrew L.] Univ Washington, Dept Med Oncol, Seattle, WA 98195 USA.
   [Mizrahi, Jonathan; Apisarnthanarax, Smith Jim; Pant, Shubham] Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA.
   [Eastman, Boryana M.] Univ Texas MD Anderson Canc Ctr, Dept Med Oncol, Houston, TX 77030 USA.
   [Dalal, Shalini] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Houston, TX 77030 USA.
   [McNearney, Terry] Pancreat Canc Act Network, Manhattan Beach, CA USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of Texas
   System; UTMD Anderson Cancer Center; University of Texas System; UTMD
   Anderson Cancer Center
RP Coveler, AL (corresponding author), 825 Eastlake Ave East,Mailstop LG-465, Seattle, WA 98109 USA.
EM acoveler@uw.edu
OI Coveler, Anew/0000-0003-1710-5637
FU NCI NIH HHS [T32 CA009666] Funding Source: Medline
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NR 127
TC 66
Z9 72
U1 7
U2 29
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD JUN
PY 2021
VL 26
IS 6
BP E971
EP E982
DI 10.1002/onco.13796
EA MAY 2021
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SN2ZZ
UT WOS:000649456000001
PM 33885205
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Oberoi, D
   Reed, EN
   Piedalue, KA
   Landmann, J
   Carlson, LE
AF Oberoi, Devesh
   Reed, Erica N.
   Piedalue, Katherine-Ann
   Landmann, Jessa
   Carlson, Linda E.
TI Exploring patient experiences and acceptability of group vs. individual
   acupuncture for Cancer-related pain: a qualitative study
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Oncology; Acupuncture; Group acupuncture; Individual acupuncture;
   Qualitative; Patient experience; Social support; Patient privacy
ID INTEGRATIVE ONCOLOGY; COMPLEMENTARY; CHEMOTHERAPY; THERAPIES; TRIAL
AB Background: Individual acupuncture (AP) is a safe and effective treatment for cancer-related pain and other symptoms in cancer survivors. However, access to individual AP is limited, and costs can be prohibitive. Group AP could be a more cost-effective alternative as it is less expensive and non-inferior to individual AP for pain relief. Despite growing evidence in favour of group AP, patient acceptability and experience of group AP in cancer patients is relatively unknown. This exploratory study sought to compare patient experiences and acceptability of group versus individual AP in cancer patients.
   Methods: Semi-structured, open-ended, in-depth interviews were conducted in a subset of 11 cancer patients enrolled in a randomized non-inferiority trial of group vs. individual AP for cancer pain. Participants for this study were recruited via purposive sampling, aiming for diversity in age, sex, education, employment, cancer types, and treatment arms. Data was analyzed using inductive thematic analysis.
   Results: Two major themes were identified: a) overall experience of AP treatment b) value of AP. Participants across both treatment arms acknowledged improvement in pain, quality of sleep, mood and fatigue. Participants in the group AP arm reported a significant increase in perceived social support, while participants in the individual arm valued privacy and one-on-one interaction with the acupuncturist. Although some participants in the group arm had privacy-related concerns before the commencement of the program, these concerns waned after a few AP sessions. Participants across both the treatment arms reported cordial clinician-patient relationship with the acupuncturist. Willingness to pursue AP treatment in the future was comparable across both the treatment arms and was limited by out-of-pocket costs.
   Conclusion: Patient acceptability and experience of treatment in group AP was on par with individual AP. Group AP may further augment perceived social support among patients and privacy concerns, if any, subside after a few sessions.
C1 [Oberoi, Devesh; Reed, Erica N.; Piedalue, Katherine-Ann; Carlson, Linda E.] Univ Calgary, Cumming Sch Med, Dept Oncol, Div Psychosocial Oncol, Calgary, AB, Canada.
   [Landmann, Jessa] Vive Integrat Hlth Grp, 1889-45 St NW, Calgary, AB, Canada.
   [Carlson, Linda E.] Tom Baker Canc Clin, Dept Psychosocial Oncol, Canc Control Alberta, Holy Cross Site,2202 2nd St SW, Calgary, AB T2S 3C1, Canada.
C3 University of Calgary; Tom Baker Cancer Clinic; University of Calgary
RP Carlson, LE (corresponding author), Univ Calgary, Cumming Sch Med, Dept Oncol, Div Psychosocial Oncol, Calgary, AB, Canada.; Carlson, LE (corresponding author), Tom Baker Canc Clin, Dept Psychosocial Oncol, Canc Control Alberta, Holy Cross Site,2202 2nd St SW, Calgary, AB T2S 3C1, Canada.
EM lcarlso@ucalgary.ca
RI Carlson, Linda E/AEN-5702-2022
OI Carlson, Linda E/0000-0002-4411-2085
FU Enbridge Research Chair in Psychosocial Oncology - Canadian Cancer
   Society Alberta/NWT Division; Alberta Cancer Foundation
FX This study was funded by the Enbridge Research Chair in Psychosocial
   Oncology, held by LEC and co-funded by the Canadian Cancer Society
   Alberta/NWT Division and the Alberta Cancer Foundation. The funding body
   had no role in the design of the study and collection, analysis, and
   interpretation of data, and in writing the manuscript.
CR [Anonymous], 1999, Doing Qualitative Research
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NR 30
TC 9
Z9 9
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD JUN 13
PY 2022
VL 22
IS 1
AR 155
DI 10.1186/s12906-022-03600-6
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2C2BG
UT WOS:000810679300004
PM 35698124
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, YY
   Yin, CY
   Li, XJ
   Liu, BY
   Wang, J
   Zheng, XL
   Shao, XM
   Liang, Y
   Du, JY
   Fang, JQ
   Liu, BY
AF Li, Yuanyuan
   Yin, Chengyu
   Li, Xiaojie
   Liu, Boyu
   Wang, Jie
   Zheng, Xiaoli
   Shao, Xiaomei
   Liang, Yi
   Du, Junying
   Fang, Jianqiao
   Liu, Boyi
TI Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic
   Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in
   Sensory Neurons
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Paclitaxel; acupuncture; dorsal root ganglion; peripheral neuropathy;
   TRPV1; glial cell; TLR4
ID POTENTIAL VANILLOID 1; CHEMOTHERAPY; RECEPTOR; ACTIVATION; MECHANISMS;
   RESPONSES; ACUPUNCTURE; CONTRIBUTES; ASTROCYTES; ROLES
AB Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and in cancer survivors. Conventional therapies are usually ineffective and possess adverse effects. Here, we examined the effects of electroacupuncture (EA) on a rat model of paclitaxel-induced neuropathic pain and related mechanisms. EA robustly and persistently alleviated paclitaxel-induced pain hypersensitivities. Mechanistically, TLR4 (Toll-Like Receptor 4) and downstream signaling MyD88 (Myeloid Differentiation Primary Response 88) and TRPV1 (Transient Receptor Potential Vallinoid 1) were upregulated in dorsal root ganglion (DRGs) of paclitaxel-treated rats, whereas EA reduced their overexpression. Ca2+ imaging further indicated that TRPV1 channel activity was enhanced in DRG neurons of paclitaxel-treated rats whereas EA suppressed the enhanced TRPV1 channel activity. Pharmacological blocking of TRPV1 mimics the analgesic effects of EA on the pain hypersensitivities, whereas capsaicin reversed EA's effect. Spinal astrocytes and microglia were activated in paclitaxel-treated rats, whereas EA reduced the activation. These results demonstrated that EA alleviates paclitaxel-induced peripheral neuropathic pain via mechanisms possibly involving suppressing TLR4 signaling and TRPV1 upregulation in DRG neurons, which further result in reduced spinal glia activation. Our work supports EA as a potential alternative therapy for paclitaxel-induced neuropathic pain.
C1 [Li, Yuanyuan; Yin, Chengyu; Li, Xiaojie; Liu, Boyu; Wang, Jie; Zheng, Xiaoli; Shao, Xiaomei; Liang, Yi; Du, Junying; Fang, Jianqiao; Liu, Boyi] Zhejiang Chinese Med Univ, Key Lab Acupuncture & Neurol Zhejiang Prov, Dept Neurobiol & Acupuncture Res, Clin Med Coll 3, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Fang, JQ; Liu, BY (corresponding author), Zhejiang Chinese Med Univ, Key Lab Acupuncture & Neurol Zhejiang Prov, Dept Neurobiol & Acupuncture Res, Clin Med Coll 3, Hangzhou 310053, Zhejiang, Peoples R China.
EM yuanyuanlizy@163.com; chengyu.yin@hotmail.com; 18300670930@163.com;
   lby_0731@163.com; bemyhalo@163.com; zxl861260876@163.com;
   13185097375@163.com; liangyiwww@126.com; dujunying0706@163.com;
   fangjianqiao7532@163.com; boyi.liu@foxmail.com
RI ; Yin, Chengyu/NLN-8501-2025; Du, Junying/AEV-3719-2022
OI Li, Yuanyuan/0000-0001-9012-6026; Fang, Jianqiao/0000-0002-5155-8544; 
FU National Natural Science Foundation of China [81873365, 81603676];
   Zhejiang Provincial Natural Science Funds for Distinguished Young
   Scholars [LR17H270001]; Zhejiang Chinese Medical University [Q2019J01,
   2018ZY37, 2018ZY19]
FX This research was funded by National Natural Science Foundation of China
   (81873365 and 81603676), by Zhejiang Provincial Natural Science Funds
   for Distinguished Young Scholars (LR17H270001), and by research funds
   from Zhejiang Chinese Medical University (Q2019J01, 2018ZY37, and
   2018ZY19).
CR [Anonymous], [No title captured]
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NR 61
TC 126
Z9 146
U1 4
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2019
VL 20
IS 23
AR 5917
DI 10.3390/ijms20235917
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JY5AR
UT WOS:000504428300099
PM 31775332
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hou, LL
   Xu, L
   Shi, Y
   Gu, F
AF Hou Lili
   Xu Lei
   Shi Yan
   Gu Fen
TI Effect of electric acupoint stimulation on gastrointestinal hormones and
   motility among geriatric postoperative patients with gastrointestinal
   tumors
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Electric stimulation therapy; Aged; Gastrointestinal stromal tumors;
   Gastrointestinal hormones; Gastrointestinal motility; Point ST36
   (Zusanli); Point ST37 (Shangjuxu)
AB OBJECTIVE: To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors, and to explore an efficient and noninvasive method for postoperative recovery of bowel functions.
   METHODS: Forty patients were randomly and evenly assigned into a regular nursing care group (RNC) and an acupoint electric stimulation group (AES). Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of acupoints. The serum levels of gastrin (GAS), motilin (MOT), and cholecystokinin (CCK), and an electrogastrogram (EGG) of all the patients were evaluated on the first, third, and fifth day after surgery. The time to first flatus after surgery and the number of patients with side effects such as abdominal pain, abdominal distention, and diarrhea were recorded.
   RESULTS: There were significant differences between the two groups in GAS, MOT, EGG, time to first flatus, abdominal pain, abdominal distention, and diarrhea (P < 0.05).
   CONCLUSION: Electric stimulation on acupoints could increase levels of GAS and MOT, promote the recovery of gastrointestinal functions, and decrease complications among postoperative senile patients with gastrointestinal tumors. (C) 2016 JTCM. All rights reserved.
C1 [Hou Lili] Shanghai Pulm Hosp, Dept Nursing, Shanghai 200433, Peoples R China.
   [Xu Lei] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Nursing, Shanghai 200062, Peoples R China.
   [Shi Yan] Tongji Univ, Peoples Hosp 10, Dept Nursing, Shanghai 200072, Peoples R China.
   [Gu Fen] Shanghai Pulm Hosp, Resp Dept, Shanghai 200433, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Tongji University
RP Shi, Y (corresponding author), Tongji Univ, Peoples Hosp 10, Dept Nursing, Shanghai 200072, Peoples R China.; Gu, F (corresponding author), Shanghai Pulm Hosp, Resp Dept, Shanghai 200433, Peoples R China.
EM hulizhikong@yahoo.com; gufen927@163.com
RI Hou, Lili/IUN-0179-2023
FU National Natural Science Foundation Project of China (Transcutaneous
   Electrical Acupoint Stimulation Prevents the Deep Vein Thrombosis: the
   Role of Endothelium Modulation) [81202750]
FX Supported by the National Natural Science Foundation Project of China
   (Transcutaneous Electrical Acupoint Stimulation Prevents the Deep Vein
   Thrombosis: the Role of Endothelium Modulation, No. 81202750)
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NR 13
TC 23
Z9 24
U1 3
U2 22
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD AUG 15
PY 2016
VL 36
IS 4
BP 450
EP 455
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DS8WV
UT WOS:000381064600006
PM 28459508
OA hybrid
DA 2026-01-16
ER

PT J
AU de Valois, B
   Asprey, A
   Young, T
AF de Valois, Beverley
   Asprey, Anthea
   Young, Teresa
TI "The Monkey on Your Shoulder": A Qualitative Study of Lymphoedema
   Patients' Attitudes to and Experiences of Acupuncture and Moxibustion
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ALTERNATIVE MEDICINE USE; BREAST-CANCER PATIENTS; OF-LIFE; SECONDARY
   LYMPHEDEMA; PSYCHOSOCIAL IMPACT; HOT FLASHES; HEAD; COMPLEMENTARY;
   SYMPTOMS; FEASIBILITY
AB Background. Lymphoedema, a distressing consequence of cancer treatment, has significant negative impact on health-related quality of life. Multidisciplinary approaches are needed to improve physical and psychosocial wellbeing. Acupuncture and moxibustion (acu/moxa), two modalities of traditional East Asian medicine, may contribute to improved outcomes for cancer survivors with lymphoedema. Aim. To explore how patients with lymphoedema secondary to cancer treatment perceive and experience acu/moxa treatment. Design and Setting. A qualitative focus group study, nested in a 3-step mixed methods observational study, was carried out in a cancer drop-in and information centre in north-west London. Methods. Six focus groups and one telephone interview were conducted with 23 survivors of breast or head and neck cancer, who had completed up to 13 acu/moxa treatments. Scripts were transcribed, coded, and analysed to identify salient and overarching themes. Results. Participants described feeling disempowered by cancer treatment and subsequent diagnosis of lymphoedema. Acu/moxa was valued for its whole-person approach and for time spent with a practitioner who cared, listened, and responded. Participants reported changes in physical and psychosocial health, including increased energy levels and reduced pain and discomfort, and feelings of empowerment, personal control, and acceptance. Many were motivated to improve self-care. Conclusion. Many participants who received acu/moxa treatment reported improved wellbeing and a more proactive attitude towards self-care.
C1 [de Valois, Beverley; Young, Teresa] Mt Vernon Canc Ctr, Lynda Jackson Macmillan Ctr, Support Oncol Res Team, Rickmansworth Rd, Northwood HA6 2RN, Middx, England.
   [Asprey, Anthea] Univ Exeter, Sch Med, Magdalen Rd, Exeter EX1 2LU, Devon, England.
C3 Mount Vernon Cancer Centre; University of Exeter
RP de Valois, B (corresponding author), Mt Vernon Canc Ctr, Lynda Jackson Macmillan Ctr, Support Oncol Res Team, Rickmansworth Rd, Northwood HA6 2RN, Middx, England.
EM beverley.devalois@nhs.net
OI de Valois, Beverley/0000-0002-0665-1432; Young,
   Teresa/0000-0003-0367-2980
FU National Institute for Health Research (NIHR) under its Research for
   Innovation, Speculation and Creativity (RISC) Programme
   [PB-PG-0407-10086]
FX The authors thank the National Institute of Health Research for funding
   this study; Elaine Melsome, Macmillan Lymphoedema Nurse Specialist,
   Mount Vernon Hospital Lymphoedema Service, who referred patients to the
   study; and Dr. Charlotte Paterson and Dr. Christy Barry, who read and
   offered advice on this paper. The authors are grateful to the study
   participants who generously gave their time to share their experiences.
   This paper presents independent research commissioned by the National
   Institute for Health Research (NIHR) under its Research for Innovation,
   Speculation and Creativity (RISC) Programme (Grant Reference no.
   PB-PG-0407-10086).
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NR 57
TC 6
Z9 8
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 4298420
DI 10.1155/2016/4298420
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA DU2OL
UT WOS:000382050300001
PM 27630734
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Ma, WG
   Si, YX
   Zhang, YL
   Gao, WF
   Dong, YG
   Li, YQ
   Xu, ZF
   Xi, Q
   Li, ZZ
AF Ma, Wei-Gang
   Si, Yu-Xin
   Zhang, Yong-Long
   Gao, Wei-Fang
   Dong, Yu-Ge
   Li, Yan-Qi
   Xu, Zhi-Fang
   Xi, Qiang
   Li, Zhong-Zheng
TI Combining acupuncture and mesenchymal stem cell therapy offers promise
   as a treatment for inflammatory bowel disease
SO WORLD JOURNAL OF STEM CELLS
LA English
DT Review
DE Acupuncture; Mesenchymal stem cell; Inflammatory bowel disease;
   Anti-inflammatory; Oxidative stress
ID REACTIVE OXYGEN METABOLITES; BONE-MARROW; ELECTROACUPUNCTURE PROMOTES;
   ULCERATIVE-COLITIS; CROHNS-DISEASE; MACROPHAGE POLARIZATION; EFFECTOR
   FUNCTION; INTERFERON-GAMMA; TH17 CELLS; DIFFERENTIATION
AB Inflammatory bowel disease (IBD) is a persistent gastrointestinal ailment driven by a range of immunological and pathophysiological factors, and often exposes patients to persistent pain and a greater risk of tumor development. In clinical settings, sulfasalazine is among the most common treatments used to manage IBD, but such treatment can result in a range of side effects in addition to leading to relatively poor efficacy. In certain refractory cases, patients must undergo surgical resection of affected tissues, underscoring the need to devise safer and more efficacious forms of alternative treatment. Mesenchymal stem cells (MSCs) have recently been shown to exhibit been shown to exhibit robust immunomodulatory activity and potential for differentiation such that they may be an effective tool for treating IBD. Acupuncture has also shown promise as an efficacious treatment option for IBD, performing better than drug-based treatments in certain clinical trials. Acupuncture is capable of enhancing endogenous MSC proliferation and homing, enabling these cells to more effectively migrate toward target lesion sites and to promote tissue repair. In light of these findings, this review was formulated to survey the potential therapeutic advantages of combining MSCs and acupuncture when attempting to treat IBD.
C1 [Ma, Wei-Gang; Si, Yu-Xin; Zhang, Yong-Long; Gao, Wei-Fang; Dong, Yu-Ge; Xu, Zhi-Fang] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China.
   [Li, Yan-Qi; Xi, Qiang] Tianjin Univ Tradit Chinese Med, Dept Clin Practice, Tianjin 301617, Peoples R China.
   [Li, Zhong-Zheng] Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Tuina, Res Ctr Expt Acupuncture Sci, 10 Poyanghu Rd West Area, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Li, ZZ (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Acupuncture & Tuina, Res Ctr Expt Acupuncture Sci, 10 Poyanghu Rd West Area, Tianjin 301617, Peoples R China.
EM lizhzh2008@163.com
FU National Natural Science Foundation of China [82174524]
FX Supported by the National Natural Science Foundation of China, No.
   82174524
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NR 158
TC 0
Z9 0
U1 6
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-0210
J9 WORLD J STEM CELLS
JI World J. Stem Cells
PD JUL 26
PY 2025
VL 17
IS 7
AR 105371
DI 10.4252/wjsc.v17.i7.105371
PG 18
WC Cell & Tissue Engineering; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 5LL8H
UT WOS:001538500300002
PM 40740536
OA Green Accepted, hybrid
DA 2026-01-16
ER

PT J
AU Chien, TJ
   Liu, CY
   Fang, CJ
   Kuo, CY
AF Chien, T. -J.
   Liu, C. -Y.
   Fang, C. -J.
   Kuo, C. -Y.
TI The maintenance effect of acupuncture on breast cancer-related menopause
   symptoms: a systematic review
SO CLIMACTERIC
LA English
DT Review
DE Acupuncture; breast cancer; hot flushes; menopause symptom; systematic
   review
ID HOT FLASHES; VASOMOTOR SYMPTOMS; HORMONE-THERAPY; APPLIED RELAXATION;
   SKIN-CONDUCTANCE; CONTROLLED-TRIAL; JOINT PAIN; WOMEN;
   ELECTROACUPUNCTURE; METAANALYSIS
AB Background: Acupuncture has been used for many breast cancer treatment-related problems, but how long the effect lasts is unknown. This meta-analysis aims to evaluate how long the effect of acupuncture on breast cancer-related hot flushes and menopause symptoms lasts. Methods: The research design followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement, without language restrictions. Seven databases from inception through February 2019 were accessed; only randomized clinical trials (RCTs) that examined the maintenance effect of acupuncture on hot flushes or menopause symptoms after treatment were included. Cochrane criteria were followed and RevMan 5.2 software was used to analyze trials. Results: In total, 943 patients from 13 RCTs were analyzed. The meta-analysis showed that acupuncture had no significant long-term maintenance effect on the frequency or severity of hot flushes (p?=?0.29; p?=?0.34), but had a significant 3-month maintenance effect of ameliorating menopause symptoms at 3 months after treatment ended (p?=?0.001). No adverse events were reported. Conclusions: Acupuncture significantly alleviated menopause symptoms for at least 3 months, but not hot flushes. Breast cancer patients concerned about the adverse effects of hormone therapy could consider acupuncture as an alternative. Additional acupuncture at 3 months after the initial treatment course could be considered. A large-scale study may help to define the optimal guideline for this issue.
C1 [Chien, T. -J.] Taipei City Hosp, Dept Internal Med, Div Hematooncol, Branch Zhong Zhou & Jen Ai, Taipei, Taiwan.
   [Chien, T. -J.; Liu, C. -Y.; Kuo, C. -Y.] Natl Yang Ming Univ, Inst Tradit Med, Taipei, Taiwan.
   [Liu, C. -Y.] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Liu, C. -Y.] China Med Univ, Sch Chinese Med, Taichung, Taiwan.
   [Liu, C. -Y.] Flourish Tradit Chinese Med Clin, Taipei, Taiwan.
   [Fang, C. -J.] Natl Cheng Kung Univ, Med Lib, Tainan, Taiwan.
   [Fang, C. -J.] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Secretariat, Tainan, Taiwan.
C3 Taipei City Hospital; National Yang Ming Chiao Tung University; Chang
   Gung University; China Medical University Taiwan; National Cheng Kung
   University; National Cheng Kung University; National Cheng Kung
   University Hospital
RP Chien, TJ (corresponding author), Taipei City Hosp, Dept Internal Med, Div Hematooncol, Branch Zhong Zhou & Jen Ai, Taipei, Taiwan.
EM silence021@gmail.com
RI ; Fang, Ching-Ju/B-4221-2009
OI Chien, Tsai Ju/0000-0001-9646-5272; Fang, Ching-Ju/0000-0002-7892-8840
FU Ministry of Science and Technology - MOST, Taiwan [107-2635-B-532-003-]
FX The study is supported by Ministry of Science and Technology - MOST,
   Taiwan [grant 107-2635-B-532-003-].
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   2006, HLTH NEWS, V12, P11
NR 62
TC 15
Z9 19
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD MAR 3
PY 2020
VL 23
IS 2
BP 130
EP 139
DI 10.1080/13697137.2019.1664460
EA OCT 2019
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA KI1HZ
UT WOS:000490441400001
PM 31612733
DA 2026-01-16
ER

PT J
AU Wang, F
   Ye, ZH
   Yin, XJ
   Zhou, CC
   Zhong, M
   Zhao, GF
AF Wang, Feng
   Ye, Zhihui
   Yin, Xiuju
   Zhou, Chengcheng
   Zhong, Min
   Zhao, Gaofeng
TI Electroacupuncture at 5/100 Hz alleviates neuropathic pain in rats by
   inhibiting the CCL3/CCR5 axis in the spinal cord
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE CCL3; CCR5; electroacupuncture; glial cells; neuropathic pain;
   proinflammatory factors
ID RECEPTOR 5; ACUPUNCTURE; CHEMOKINES
AB Objective: Typically, neuropathic pain (NP) is difficult to manage as it is refractory to conventional medications. Electroacupuncture (EA) at 5/100 Hz has emerged as an effective and promising treatment for NP; however, its mechanism of action is still uncertain. Accordingly, this study investigated the alleviatory mechanism of EA in chronic compression injury (CCI)-induced chronic pain via the C-C chemokine ligand 3 / C-C chemokine receptor type 5 (CCL3/CCR5) axis.Methods: The CCI model was established in rats to induce NP. Mechanical and thermal hyperalgesia were assessed with von Frey and Hargreaves tests, respectively. From day 8 after CCI, EA (5/100 Hz) was performed for 1 week (30 min/day). CCL3 and CCR5 expression was detected with Western blotting and immunofluorescence. Glial cell activation was determined through co-labeling of neurons and glial cells with antibodies against CCL3 and CCR5. The release of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha was tested with enzyme-linked immunosorbent assay (ELISA).Results: EA markedly ameliorated CCI-induced chronic NP in rats and reduced CCL3 and CCR5 expression in the rat spinal cord. CCL3 and CCR5 were co-expressed by neurons and microglia in the central nervous system. In addition, EA also repressed the activation of glial cells and levels of IL-1 beta, IL-6 and TNF-alpha.Conclusion: EA may mitigate chronic NP in rats by blocking the CCL3/CCR5 axis in the spinal cord. In addition, EA appeared to exert anti-inflammatory and analgesic effects by suppressing glial cell activation. These findings add to our understanding of the mechanism of EA-induced analgesia.
C1 [Wang, Feng; Zhong, Min; Zhao, Gaofeng] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Anesthesiol, 11 Dade Rd, Guangzhou 510000, Guangdong, Peoples R China.
   [Ye, Zhihui; Yin, Xiuju; Zhou, Chengcheng] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zhao, GF (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Anesthesiol, 11 Dade Rd, Guangzhou 510000, Guangdong, Peoples R China.
EM zhaogaofengzyy@163.com
OI Zhou, Chengcheng/0000-0002-5656-9605; Yin, Xiuju/0000-0003-2865-8077
FU Natural Science Foundation of Guangdong Province [2020A1515010957]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the Natural Science Foundation of Guangdong Province (grant
   no. 2020A1515010957).
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NR 36
TC 0
Z9 0
U1 2
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2025
VL 43
IS 2
BP 95
EP 103
DI 10.1177/09645284251327197
EA MAR 2025
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0WR6R
UT WOS:001450518800001
PM 40119762
DA 2026-01-16
ER

PT J
AU Zhang, H
   Guo, QY
   Song, RL
   He, JR
   Jia, NN
   Shi, H
   Chen, SQ
AF Zhang, Hong
   Guo, Qian-Yu
   Song, Rui-Ling
   He, Jiao-Rong
   Jia, Ning-Ning
   Shi, Hong
   Chen, Su-Qing
TI Efficacy of Moxibustion Combined With Refined Nursing Care on Pain
   Reduction in Gouty Arthritis
SO ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH
LA English
DT Article; Early Access
DE Arthritis; gout; pain; refined nursing; traditional Chinese medicine
   nursing
ID INTERVENTION
AB Objective: This study aimed to evaluate the therapeutic efficacy of moxibustion with moxa sticks combined with refined nursing care in alleviating pain in individuals with gouty arthritis. Methods: A randomized controlled trial was conducted from March 2022 to January 2024, involving 96 patients diagnosed with gouty arthritis who were admitted to our hospital. The participants were randomly assigned to either the observation group (n = 48, treated with moxibustion intervention) or the control group (n = 48). The observation group received moxibustion treatment, while the control group underwent standard Western medical treatment. Both groups received refined nursing care during the intervention. Pain improvement, laboratory indicators, swelling levels, and clinical efficacy of both groups were compared. Results: The observation group demonstrated significantly lower visual analog scale (VAS) scores at 3- and 7-day postintervention, compared with the control group (P < 0.05). Additionally, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and uric acid (UA) levels and limb swelling were all markedly reduced in the observation group 7 days after treatment (P < 0.05). The observation group also exhibited a higher overall effective rate compared with the control group (P < 0.05). Conclusion: The combination of moxibustion and refined nursing care in the treatment of gouty arthritis provides significant therapeutic benefits, including the reduction of joint swelling, pain, and uric acid levels. This integrated approach may represent an effective strategy for managing gouty arthritis.
C1 [Zhang, Hong; Guo, Qian-Yu; Song, Rui-Ling; He, Jiao-Rong; Jia, Ning-Ning; Shi, Hong] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp,Hosp 3, Shanxi Acad Med Sci,Dept Rheumatol & Immunol, Taiyuan, Peoples R China.
   [Chen, Su-Qing] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp,Hosp 3, Shanxi Acad Med Sci,Dept Otorhinolaryngol Head & N, 99 Longcheng Ave, Taiyuan 030032, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University
RP Chen, SQ (corresponding author), Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp,Hosp 3, Shanxi Acad Med Sci,Dept Otorhinolaryngol Head & N, 99 Longcheng Ave, Taiyuan 030032, Peoples R China.
EM suqingchencsq@126.com
RI Guo, Qianyu/LMP-6559-2024
CR Chen J., 2022, Zhong Yi Yan Jiu, V35, P40
   Chen Y., 2021, Journal of Changchun University of Chinese Medicine, V37, P430
   Dalbeth N, 2021, LANCET, V397, P1843, DOI 10.1016/S0140-6736(21)00569-9
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   Yu QN, 2021, AM J TRANSL RES, V13, P11671
   Zhang W. F., 2022, Zhong Yi Wai Zhi Za Zhi, V31, P68
NR 17
TC 0
Z9 0
U1 2
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0360-1293
EI 2167-9010
J9 ACUPUNCTURE ELECTRO
JI Acupunct. Electro-Ther. Res.
PD 2025 JUL 31
PY 2025
DI 10.1177/03601293251362861
EA JUL 2025
PG 15
WC Integrative & Complementary Medicine; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Neurosciences & Neurology
GA 5QA4A
UT WOS:001541601700001
DA 2026-01-16
ER

PT J
AU Shao, YL
   Fan, LY
AF Shao, Yanlong
   Fan, Lingyu
TI Effects of acupuncture-moxibustion at Du channel combined with
   triamcinolone acetonide on clinical treatment efficacy and quality of
   life in patients with sciatica
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Sciatica; triamcinolone acetonide; acupuncture-moxibustion at Du
   channel; quality of life; dysfunction
ID PAIN
AB Objective: To investigate the effects of acupuncture-moxibustion at Du channel combined with triamcinolone acetonide (AMDCTA) on the clinical treatment efficacy and quality of life in patients with sciatica. Methods: A retrospective study was conducted on 86 patients with sciatica admitted to Tianjin Hospital from March 2018 to April 2020. According to different treatment methods, the patients were divided into an observation group (45 cases) and a control group (41 cases). The control group was treated with triamcinolone acetonide, while the observation group was treated with AMDCTA, both lasted for 3 weeks. Clinical treatment efficacy, visual analogue scale score, straight leg raising score, Oswestry dysfunction index score, 36-item short-form health survey quality of life score, serum insulin-like growth factor-1 (IGF-1) level, tumor necrosis factor-alpha (TNF-alpha) level, monocyte chemoattractant protein-1 (MCP-1) level, and the incidence of adverse reactions in both groups were compared. Results: The total effective rate of the observation group was significantly higher compared with that of the control group (P < 0.05). Visual analogue scale and Oswestry dysfunction index scores in both groups were significantly lower compared with those before treatment, and the scores of the observation group were significantly lower compared with the control group after treatment (all P < 0.05). Straight leg raising and 36-item short-form health survey quality of life scores in both groups were significantly improved compared with those before treatment, and those in the observation group were significantly higher compared with the control group after treatment (all P < 0.05). IGF-1, TNF-alpha and MCP-1 levels in both groups were significantly lower compared with those before treatment, and those levels in the observation group were lower compared with those in the control group after treatment (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: AMDCTA had a definite curative effect on sciatica, could effectively improve patients' pain, functional activity and quality of life, as well as reduce IGF-1, TNF-alpha and MCP-1 levels; revealing it is safe and reliable.
C1 [Shao, Yanlong] Tianjin Hosp, Dept Orthoped & Traumatol Integrated Tradit Chine, 406 Jiefang South Rd, Tianjin 300021, Peoples R China.
   [Fan, Lingyu] Tianjin Hosp, Dept Cardlol, Tianjin, Peoples R China.
C3 Tianjin University; Tianjin University
RP Shao, YL (corresponding author), Tianjin Hosp, Dept Orthoped & Traumatol Integrated Tradit Chine, 406 Jiefang South Rd, Tianjin 300021, Peoples R China.
EM shaoyanlongts3j@163.com
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NR 26
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 12
BP 9751
EP 9759
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PO2SX
UT WOS:000605020700074
DA 2026-01-16
ER

PT J
AU Greenlee, H
   DuPont-Reyes, MJ
   Balneaves, LG
   Carlson, LE
   Cohen, MR
   Deng, G
   Johnson, JA
   Mumber, M
   Seely, D
   Zick, SM
   Boyce, LM
   Tripathy, D
AF Greenlee, Heather
   DuPont-Reyes, Melissa J.
   Balneaves, Lynda G.
   Carlson, Linda E.
   Cohen, Misha R.
   Deng, Gary
   Johnson, Jillian A.
   Mumber, Matthew
   Seely, Dugald
   Zick, Suzanna M.
   Boyce, Lindsay M.
   Tripathy, Debu
TI Clinical Practice Guidelines on the Evidence-Based Use of Integrative
   Therapies During and After Breast Cancer Treatment
SO CA-A CANCER JOURNAL FOR CLINICIANS
LA English
DT Review
DE acupressure; acupuncture; breast cancer; complementary therapies;
   integrative medicine; integrative oncology; massage; meditation; music
   therapy; stressmanagement; yoga
ID QUALITY-OF-LIFE; CHEMOTHERAPY-INDUCED NAUSEA; RANDOMIZED
   CONTROLLED-TRIAL; STRESS-MANAGEMENT INTERVENTION; MANUAL LYMPHATIC
   DRAINAGE; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY;
   COGNITIVE-BEHAVIORAL THERAPY; EXPRESSIVE GROUP-THERAPY; DOUBLE-BLIND
   TRIAL
AB Patients with breast cancer commonly use complementary and integrative therapies as supportive care during cancer treatment and to manage treatment-related side effects. However, evidence supporting the use of such therapies in the oncology setting is limited. This report provides updated clinical practice guidelines from the Society for Integrative Oncology on the use of integrative therapies for specific clinical indications during and after breast cancer treatment, including anxiety/stress, depression/mood disorders, fatigue, quality of life/physical functioning, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance. Clinical practice guidelines are based on a systematic literature review from 1990 through 2015. Music therapy, meditation, stress management, and yoga are recommended for anxiety/stress reduction. Meditation, relaxation, yoga, massage, and music therapy are recommended for depression/mood disorders. Meditation and yoga are recommended to improve quality of life. Acupressure and acupuncture are recommended for reducing chemotherapy-induced nausea and vomiting. Acetyl-L-carnitine is not recommended to prevent chemotherapy-induced peripheral neuropathy due to a possibility of harm. No strong evidence supports the use of ingested dietary supplements to manage breast cancer treatment-related side effects. In summary, there is a growing body of evidence supporting the use of integrative therapies, especially mind-body therapies, as effective supportive care strategies during breast cancer treatment. Many integrative practices, however, remain understudied, with insufficient evidence to be definitively recommended or avoided. (C) 2017 American Cancer Society.
C1 [Greenlee, Heather; DuPont-Reyes, Melissa J.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, 722 West 168th St,Seventh Fl, New York, NY 10032 USA.
   [Greenlee, Heather] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA.
   [Balneaves, Lynda G.] Rady Fac Hlth Sci, Coll Nursing, Winnipeg, MB, Canada.
   [Carlson, Linda E.] Univ Calgary, Dept Oncol, Calgary, AB, Canada.
   [Cohen, Misha R.] Calif Inst Integral Studies, Amer Coll Tradit Chinese Med, San Francisco, CA USA.
   [Cohen, Misha R.] Chicken Soup Chinese Med, San Francisco, CA USA.
   [Deng, Gary] Mem Sloan Kettering Canc Ctr, Integrat Oncol, 1275 York Ave, New York, NY 10021 USA.
   [Johnson, Jillian A.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Mumber, Matthew] Harbin Clin, Rome, GA USA.
   [Seely, Dugald] Ottawa Integrat Canc Ctr, Ottawa, ON, Canada.
   [Seely, Dugald] Canadian Coll Naturopath Med, Res, Toronto, ON, Canada.
   [Zick, Suzanna M.] Univ Michigan, Dept Family Med, Michigan Med, Ann Arbor, MI 48109 USA.
   [Zick, Suzanna M.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
   [Boyce, Lindsay M.] Mem Sloan Kettering Canc Ctr, Mem Sloan Kettering Lib, 1275 York Ave, New York, NY 10021 USA.
   [Tripathy, Debu] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX USA.
C3 Columbia University; Columbia University; University of Calgary;
   Memorial Sloan Kettering Cancer Center; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; Memorial Sloan Kettering Cancer Center; University of Texas
   System; UTMD Anderson Cancer Center
RP Greenlee, H (corresponding author), Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, 722 West 168th St,Seventh Fl, New York, NY 10032 USA.
EM hg2120@columbia.edu
RI Seely, Dugald/IAR-5574-2023; Greenlee, Heather/A-1439-2011; Johnson,
   Jillian/AAU-6116-2021; Tripathy, Debu/AAW-4968-2020; Balneaves,
   Lynda/AAG-9383-2021; Carlson, Linda E/AEN-5702-2022
OI Boyce, Lindsay/0000-0002-1003-7275; Balneaves,
   Lynda/0000-0002-6535-2096; Carlson, Linda E/0000-0002-4411-2085
FU National Cancer Institute [P30CA016672] Funding Source: NIH RePORTER;
   NCI NIH HHS [P30 CA016672] Funding Source: Medline
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NR 379
TC 560
Z9 658
U1 23
U2 422
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-9235
EI 1542-4863
J9 CA-CANCER J CLIN
JI CA-Cancer J. Clin.
PD MAY-JUN
PY 2017
VL 67
IS 3
BP 195
EP 232
DI 10.3322/caac.21397
PG 38
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA EU3OC
UT WOS:000400939900004
PM 28436999
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tang, SK
   Tse, MMY
   Leung, SF
   Fotis, T
AF Tang, Shuk Kwan
   Tse, Mimi Mun Yee
   Leung, Sau Fong
   Fotis, Theofanis
TI The effectiveness, suitability, and sustainability of
   non-pharmacological methods of managing pain in community-dwelling older
   adults: a systematic review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Chronic pain; Aged; Older adults; Community-dwelling;
   Non-pharmacological interventions; Complementary therapy; Systematic
   review
ID ELDERLY-PEOPLE; KNEE OSTEOARTHRITIS; TAI-CHI; MANAGEMENT; EFFICACY;
   INTERVENTIONS; STIMULATION; POPULATION; PREVALENCE; THERAPIES
AB Background Pain is common in older adults. To maintain their quality of life and promote healthy ageing in the community, it is important to lower their pain levels. Pharmacological pain management has been shown to be effective in older adults. However, as drugs can have various side effects, non-pharmacological pain management is preferred for community-dwelling older adults. This systematic review evaluates the effectiveness, suitability, and sustainability of non-pharmacological pain management interventions for community-dwelling older adults. Methods Five databases, namely, CINHAL, Journals@Ovid, Medline, PsycInfo, and PubMed, were searched for articles. The criteria for inclusion were: full-text articles published in English from 2005 to February 2019 on randomized controlled trials, with chronic non-cancer pain as the primary outcome, in which pain was rated by intensity, using non-pharmacological interventions, and with participants over 65 years old, community-dwelling, and mentally competent. A quality appraisal using the Jadad Scale was conducted on the included articles. Results Ten articles were included. The mean age of the older adults was from 66.75 to 76. The interventions covered were acupressure, acupuncture, guided imagery, qigong, periosteal stimulation, and Tai Chi. The pain intensities of the participants decreased after the implementation of the intervention. The net changes in pain intensity ranged from - 3.13 to - 0.65 on a zero to ten numeric rating scale, in which zero indicates no pain and ten represents the worst pain. Conclusions Non-pharmacological methods of managing pain were effective in lowering pain levels in community-dwelling older adults, and can be promoted widely in the community.
C1 [Tang, Shuk Kwan; Tse, Mimi Mun Yee; Leung, Sau Fong] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Fotis, Theofanis] Univ Brighton, Sch Hlth Sci, Westlain House,Village Way, Brighton BN1 9PH, E Sussex, England.
C3 Hong Kong Polytechnic University; University of Brighton
RP Tang, SK (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
EM skangel.tang@connect.polyu.hk
RI Leung, Sau/G-2766-2017; Fotis, Theofanis/M-6576-2013; Tang,
   Angel/AAI-8452-2020
OI Fotis, Theofanis/0000-0002-8885-040X; 
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NR 43
TC 30
Z9 40
U1 0
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 8
PY 2019
VL 19
IS 1
AR 1488
DI 10.1186/s12889-019-7831-9
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JM8AF
UT WOS:000496430300002
PM 31703654
OA Green Submitted, Green Published, gold
DA 2026-01-16
ER

PT J
AU Deng, G
   Giralt, S
   Chung, DJ
   Landau, H
   Siman, J
   Li, QS
   Lapen, K
   Mao, JJ
AF Deng, Gary
   Giralt, Sergio
   Chung, David J.
   Landau, Heather
   Siman, Jonathan
   Li, Qing S.
   Lapen, Kaitlyn
   Mao, Jun J.
TI Reduction of Opioid Use by Acupuncture in Patients Undergoing
   Hematopoietic Stem Cell Transplantation: Secondary Analysis of a
   Randomized, Sham-Controlled Trial
SO PAIN MEDICINE
LA English
DT Article
DE Pain Management; Acupuncture; Opioids; Cancer Pain
ID ORAL MUCOSITIS; MULTIPLE-MYELOMA; CANCER-TREATMENT; SYMPTOM BURDEN;
   PAIN; EFFICACY; SURGERY
AB Objective. To evaluate acupuncture as a nonpharmacologic intervention for pain management in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods. Adult patients with multiple myeloma undergoing high-dose melphalan chemotherapy and autologous peripheral blood HSCT were randomized to receive either true (TA) or sham acupuncture (SA) once daily for five days starting on the day after chemotherapy. Use of pain medications and pain scores were assessed at baseline and at days 5, 15, and 30 after transplantation. Results. Among 60 evaluable subjects, the SA group (vs TA) had greater than five times odds of increasing pain medication use from baseline. Among patients who were opioid nonusers at baseline, all 15 patients in the TA group remained free from opioid use at the end of the study. In contrast, 20% of those in the SA group (four of the 20 patients) started to use opioids after chemotherapy and stem cell infusion (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT (Fisher exact test P= 0.006). Among patients who were taking opioids at baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at day 5, and 21% (TA) vs 30% (SA) at day 30 (P= 0.86). Conclusions. Acupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post-HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients.
C1 [Deng, Gary; Li, Qing S.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA.
   [Giralt, Sergio; Chung, David J.; Landau, Heather] Mem Sloan Kettering Canc Ctr, Adult Bone Marrow Transplantat Serv, New York, NY 10021 USA.
   [Siman, Jonathan] Seattle Canc Care Alliance, Seattle, WA USA.
   [Lapen, Kaitlyn] Univ Illinois, Sch Med, Chicago, IL USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Seattle Cancer Care Alliance; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Deng, G (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, 1429 First Ave, New York, NY 10021 USA.
EM dengg@mskcc.org
OI Chung, David/0000-0003-0469-839X
FU Gateway for Cancer Research grant; MSK Translational Research and
   Integrative Medicine Grant; National Institutes of Health/National
   Cancer Institute (NIH/NCI) Cancer Center Support Grant [P30 CA008748];
   AC Israel Foundation; Byrne Fund; National Cancer Institute
   [P30CA008748] Funding Source: NIH RePORTER
FX This work was supported by a Gateway for Cancer Research grant and the
   MSK Translational Research and Integrative Medicine Grant; also, by
   National Institutes of Health/National Cancer Institute (NIH/NCI) Cancer
   Center Support Grant P30 CA008748, the AC Israel Foundation, and the
   Byrne Fund.
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NR 23
TC 15
Z9 22
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD MAR
PY 2020
VL 21
IS 3
BP 636
EP 642
DI 10.1093/pm/pnz190
PG 7
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA LS6CO
UT WOS:000536469900022
PM 31498394
OA Green Submitted, Bronze
DA 2026-01-16
ER

PT J
AU Serçe, S
   Ovayolu, Ö
   Pirbudak, L
   Ovayolu, N
AF Serce, Sibel
   Ovayolu, Ozlem
   Pirbudak, Luetfiye
   Ovayolu, Nimet
TI Response to "Statistical Concerns About Acupressure on Pain in Cancer
   Patients With Bone Metastasis Trial"
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Letter
C1 [Serce, Sibel] Gaziantep Univ Hosp, Gaziantep, Turkey.
   [Ovayolu, Ozlem; Pirbudak, Luetfiye; Ovayolu, Nimet] Gaziantep Univ, Gaziantep, Turkey.
C3 Gaziantep University; Gaziantep University
RP Ovayolu, Ö (corresponding author), Gaziantep Univ, Dept Nursing, Fac Hlth Sci, TR-27310 Gaziantep, Turkey.
EM oucan@gantep.edu.tr
RI Ovayolu, Ozlem/AAG-5541-2020
OI Ovayolu, Ozlem/0000-0002-7335-4032
CR Santillan-Garcia A, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419827087
   Serçe S, 2018, INTEGR CANCER THER, V17, P728, DOI 10.1177/1534735418769153
NR 2
TC 0
Z9 0
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD MAR 18
PY 2019
VL 18
AR 1534735419834355
DI 10.1177/1534735419834355
PG 1
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA HP4HG
UT WOS:000461636400001
PM 30879342
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Xu, M
   Fei, Y
   He, QL
   Fu, J
   Zhu, JJ
   Tao, JC
   Ni, CB
   Xu, CF
   Zhou, QH
   Yao, M
   Ni, HD
AF Xu, Miao
   Fei, Yong
   He, Qiuli
   Fu, Jie
   Zhu, Jianjun
   Tao, Jiachun
   Ni, Chaobo
   Xu, Chengfei
   Zhou, Qinghe
   Yao, Ming
   Ni, Huadong
TI Electroacupuncture Attenuates Cancer-Induced Bone Pain via NF-κB/CXCL12
   Signaling in Midbrain Periaqueductal Gray
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Article
DE Electroacupuncture; NF-kappa B; CXCL12; PAG; cancer-induced bone pain
ID FACTOR-KAPPA-B; MECHANICAL ALLODYNIA; EXPRESSION; ACUPUNCTURE;
   HYPERSENSITIVITY; CONTRIBUTES; RECEPTORS; MODEL; TRPV1; P2X3
AB Electroacupuncture (EA) is effective in various chronic pains. NF-kappa B and CXCL12 modulate the formation of chronic pain. Herein, we hypothesized that EA alleviates cancer-induced bone pain (CIBP) through NF-kappa B/CXCL12 axis in midbrain periaqueductal gray (PAG), which participates in "top-down" pain modulatory circuits. In order to filter the optimum EA frequency for CIBP treatment, 2, 100, or 2/100 Hz EA was set up. In addition, ipsilateral, contralateral, and bilateral EA groups were established to affirm the optimal EA scheme. Bilateral 2/100 Hz EA was considered as the optimal therapeutic scheme and was applied in a subsequent experiment. Western blotting along with immunofluorescence illustrated that CIBP induces a rapid and substantial increase in CXCL12 protein level and NF-kappa B phosphorylation in vlPAG from day 6 to day 12. Anti-CXCL12 neutralizing antibody and pAAV-U6-shRNA(CXCL12)-CMV-EGFP-WPRE in vlPAG remarkably improved the mechanical pain threshold of the hind paw in CIBP model relative to the control. EA inhibited the upregulation of pNF-kappa B and CXCL12 in vlPAG of CIBP. The recombinant CXCL12 and pAAV-CMV-CXCL12-EF1a-EGFP-3Xflag-WPRE reversed the abirritation of EA in the CIBP rat model. NF-kappa B phosphorylation mediated-CXCL12 expression contributed to CIBP allodynia, whereas EA suppressed NF-kappa B phosphorylation in CIBP. According to the above evidence, we conclude that bilateral 2/100 Hz EA is an optimal therapeutic scheme for CIBP. The abirritation mechanism of EA might reduce the expression of CXCL12 by inhibiting the activation of NF-kappa B, which might lead to the restraint of descending facilitation of CIBP.
C1 [Xu, Miao; Fei, Yong; He, Qiuli; Fu, Jie; Zhu, Jianjun; Tao, Jiachun; Ni, Chaobo; Xu, Chengfei; Zhou, Qinghe; Yao, Ming; Ni, Huadong] Jiaxing Univ, Affiliated Hosp, Dept Anesthesiol, Jiaxing 314001, Peoples R China.
   [Xu, Miao; Fei, Yong; He, Qiuli; Fu, Jie; Zhu, Jianjun; Tao, Jiachun; Ni, Chaobo; Xu, Chengfei; Zhou, Qinghe; Yao, Ming; Ni, Huadong] Jiaxing Univ, Affiliated Hosp, Pain Res Ctr, Jiaxing 314001, Peoples R China.
C3 Jiaxing University; Jiaxing University
RP Ni, HD (corresponding author), Jiaxing Univ, Affiliated Hosp, Dept Anesthesiol, Jiaxing 314001, Peoples R China.; Ni, HD (corresponding author), Jiaxing Univ, Affiliated Hosp, Pain Res Ctr, Jiaxing 314001, Peoples R China.
EM huadongni@126.com
RI Zhou, Qing-he/GRS-0710-2022; Ni, Huadong/AAU-8020-2020
FU National Science Foundation for Young Scientists of China [81901124];
   Natural Science Foundation of Zhejiang Province [LQ19H090007,
   Y20H090134]; Medical and Health General Research Program of Zhejiang
   Province [2020RC122, 2021RC130]; Jiaxing City Science and Technology
   Project [2021AY30023]; Key Medical Subjects Established by Zhejiang
   Province and Jiaxing City Jointly Pain Medicine [2019-ssttyx];
   Construction Project of Key Laboratory of Nerve and Pain Medicine in
   Jiaxing City; Key Laboratory of Precision Diagnosis and Treatment of
   Intractable Pain of Zhejiang Provincial
FX This study was funded, in part, by grants from the National Science
   Foundation for Young Scientists of China (Grant 81901124), the Natural
   Science Foundation of Zhejiang Province (Grants LQ19H090007 and
   Y20H090134), the Medical and Health General Research Program of Zhejiang
   Province (Grants 2020RC122 and 2021RC130), the Jiaxing City Science and
   Technology Project (Grant 2021AY30023), the Key Medical Subjects
   Established by Zhejiang Province and Jiaxing City Jointly Pain Medicine
   (Grant 2019-ssttyx), and the Construction Project of Key Laboratory of
   Nerve and Pain Medicine in Jiaxing City and Key Laboratory of Precision
   Diagnosis and Treatment of Intractable Pain of Zhejiang Provincial.
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NR 59
TC 31
Z9 37
U1 2
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD SEP 15
PY 2021
VL 12
IS 18
BP 3323
EP 3334
DI 10.1021/acschemneuro.1c00224
EA AUG 2021
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
   & Neurology
GA US2RK
UT WOS:000697282400005
PM 34460214
DA 2026-01-16
ER

PT J
AU Chen, S
   Ding, Y
   Zhang, XM
   Zhang, X
   Xiang, JJ
   Deng, YL
   Tao, XR
   Cai, WK
   Li, ZG
   Chen, JY
   Kong, FY
   Li, N
AF Chen, Shuang
   Ding, Ying
   Zhang, Xiaoming
   Zhang, Xue
   Xiang, Jiajia
   Deng, Yiling
   Tao, Xingran
   Cai, Wenke
   Li, Zhigui
   Chen, Jiayu
   Kong, Fanyi
   Li, Na
TI Efficacy of Transcutaneous Electrical Acupoint Stimulation on Chronic
   Postsurgical Pain After Video-Assisted Thoracoscopic Lobectomy: Study
   Protocol for a Prospective Randomized Controlled Trial
SO PAIN AND THERAPY
LA English
DT Article
DE Transcutaneous electrical acupuncture stimulation; Anesthesia pain
   management; Video-assisted thoracoscopic lobectomy; Trial protocol
ID BREAST-CANCER; RISK-FACTORS; SURGERY; ACUPUNCTURE; MANAGEMENT
AB IntroductionPatients undergoing video-assisted thoracoscopic lobectomy (VATL) often experience chronic postsurgical pain (CPSP). Postoperative pain can affect the recovery of postoperative lung function, prolong postoperative recovery time, and increase patient hospitalization expenses. Transcutaneous electrical acupoint stimulation (TEAS) is an alternative therapy based on acupuncture that has shown promise in postoperative recovery and pain management across various medical fields. However, research specifically focused on the improvement of CPSP after VATL is currently lacking. The purpose of this study is to evaluate whether TEAS can effectively reduce the severity and occurrence of chronic postsurgical pain in patients undergoing VATL. By investigating the potential benefits of TEAS in mitigating CPSP after VATL, this study aims to provide valuable clinical evidence to support the integration of TEAS into postoperative care protocols for patients undergoing VATL.MethodsThis study is a prospective, single-center, double-blinded, randomized controlled trial to be conducted at the 920th Hospital of Joint Logistics Support Force. Eighty patients undergoing VATL will be randomly divided into an experimental group (TEAS group) and a control group (sham group). The experimental group will receive TEAS at bilateral PC6, LI4, LR3, LU5, TE5, and LI11. The control group will not receive TEAS at the same acupoints. Both groups will receive TEAS or no TEAS before anesthesia induction and 1-7 days after surgery, with each session lasting 30 min.Planned OutcomesThe primary outcome will be the incidence of CPSP at 3 months after surgery. Secondary outcomes will include the incidence of CPSP at 6 months after surgery, the numerical rating scale (NRS) scores at 3 and 6 months after surgery, as well as the NRS scores at 24, 48, and 72 h after surgery, remifentanil consumption during general anesthesia, demand for rescue analgesics, number and duration of indwelling chest tubes, incidence of postoperative nausea and vomiting, and changes of norepinephrine (NE), cortisol (Cor), tumor necrosis factor (TNF- alpha), and interleukin 6 (IL-6) in serum.Trial RegistrationChiCTR2300069458. Registered on March 16, 2023.
C1 [Chen, Shuang; Zhang, Xiaoming; Zhang, Xue; Xiang, Jiajia; Tao, Xingran; Li, Zhigui; Li, Na] 920th Hosp Joint Logist Support Force, Dept Anesthesiol, 212 Daguan Rd, Kunming, Yunnan, Peoples R China.
   [Chen, Shuang; Zhang, Xue; Xiang, Jiajia; Deng, Yiling] Kunming Med Univ, Kunming, Yunnan, Peoples R China.
   [Ding, Ying] 920th Hosp Joint Logist Support Force, Dept Gen Surg, 212 Daguan Rd, Kunming, Yunnan, Peoples R China.
   [Deng, Yiling; Chen, Jiayu] First Peoples Hosp, Dept Orthoped, Kunming, Yunnan, Peoples R China.
   [Cai, Wenke] 920th Hosp Joint Logist Support Force, Dept Cardiothorac Surg, 212 Daguan Rd, Kunming, Yunnan, Peoples R China.
   [Kong, Fanyi] Yunnan Univ, Affiliated Hosp, Dept Neurol, 176 Qingnian Rd, Kunming, Yunnan, Peoples R China.
C3 Kunming Medical University; Yunnan University
RP Li, N (corresponding author), 920th Hosp Joint Logist Support Force, Dept Anesthesiol, 212 Daguan Rd, Kunming, Yunnan, Peoples R China.
EM chenshuangccc@163.com; 390020070@qq.com; zxdyx67899@126.com;
   3168322873@qq.com; x560412@163.com; 857092681@qq.com; 1145407250@qq.com;
   caiwenkect@126.com; lizg243509@126.com; jchenspine@163.com;
   kfy9989@hotmail.com; lina@kmmu.edu.cn
RI Xiang, Jiajia/HKE-7116-2023; Deng, Yiling/MTE-0910-2025
FU The key projects
FX We thank all study participants for their involvement in the study, and
   all the principal investigators and clinical staff participating in the
   trial for their efforts. In particular, we would also like to thank the
   patients who will participate in this trial.
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NR 25
TC 3
Z9 4
U1 0
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-8237
EI 2193-651X
J9 PAIN THER
JI PAIN THER.
PD APR
PY 2024
VL 13
IS 2
BP 269
EP 280
DI 10.1007/s40122-024-00580-y
EA FEB 2024
PG 12
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KK6Y5
UT WOS:001163788900001
PM 38367159
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhu, HD
   Gong, Z
   Hu, BW
   Wei, QL
   Kong, J
   Peng, CB
AF Zhu, Hua-dong
   Gong, Zhen
   Hu, Bing-wei
   Wei, Qiao-ling
   Kong, Jun
   Peng, Cong-bin
TI The Efficacy and Safety of Transcutaneous Acupoint Interferential
   Current Stimulation for Cancer Pain Patients With Opioid-Induced
   Constipation: A Prospective Randomized Controlled Study
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE opioid-induced constipation; lactulose; transcutaneous acupoint
   interferential current therapy; cancer pain; quality of life
ID ELECTRICAL-STIMULATION; BOWEL DYSFUNCTION; PREVALENCE; TRIAL;
   MANAGEMENT; CONDUCTION; THERAPY; BURDEN; IMPACT; ADULTS
AB Introduction. Opioid-induced constipation (OIC) is a principal complication secondary to analgesic therapy for cancer pain patients who suffer moderate to severe pain. In this study, we observe the efficacy and safety of transcutaneous acupoint interferential current (IFC) stimulation in those patients with OIC. Methods. A total of 198 patients were randomly allocated to the IFC group and control group in a 1:1 ratio. Finally, 98 patients in the IFC group received 14 sessions administered over 2 weeks, whereas 100 patients in the control group took lactulose orally during the same period. Observation items were documented at management stage and at follow-up stage according to Cleveland Constipation Scales (CCS), pain Numeric Rating Scales (NRS) and Patient Assessment of Constipation Quality of Life (PAC-QoL). Results. The total curative effects of the IFC group and the control group were indistinguishable (76.5% vs 70.0%, P = .299). Regarding CCS and PAC-QoL scores, no significant difference was observed between the 2 groups during the management time and at the follow-up stage of week 3 (P > .05, respectively), but groups were distinguished at the follow-up stage of week 4 (P < .001 and P = .031, respectively). The pain NRS decreased significantly at management stage week 2 and follow-up stage week 3 and week 4 (P = .013, P = .041, P = .011, respectively). Conclusions. Transcutaneous acupoint IFC therapy over acupoints of Tianshu (ST25) and Zhongwan (RN12) may improve constipation and quality of life in cancer patients receiving opiates; further studies are worthwhile.
C1 [Zhu, Hua-dong; Gong, Zhen; Hu, Bing-wei; Wei, Qiao-ling; Kong, Jun; Peng, Cong-bin] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.
RP Kong, J (corresponding author), Tongde Hosp Zhejiang Prov, Dept Neurosurg, 234 Gucui Rd, Hangzhou 310012, Zhejiang, Peoples R China.
EM kongjfj@163.com
RI Hu, Bing-wei/ACY-9212-2022
OI Hu, Bing-wei/0000-0002-4484-5043
CR Abramowitz L, 2013, J Med Econ, V16, P1423, DOI 10.3111/13696998.2013.851082
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NR 37
TC 8
Z9 11
U1 2
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2018
VL 17
IS 2
BP 437
EP 443
DI 10.1177/1534735417734910
PG 7
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA GF6JS
UT WOS:000432073700029
PM 29076387
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Frankel, E
   Garland, S
   Meghani, SH
   Vapiwala, N
   Mao, JJ
AF Frankel, Eitan
   Garland, Sheila
   Meghani, Salimah H.
   Vapiwala, Neha
   Mao, Jun J.
TI Patients' perspectives on integrating acupuncture into the radiation
   oncology setting
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Acupuncture; Radiotherapy; Pain; Health disparity; Knowledge; CAM
ID RANDOMIZED CONTROLLED-TRIAL; CANCER-RELATED FATIGUE; ALTERNATIVE
   MEDICINE; ORAL COMPLICATIONS; INDUCED XEROSTOMIA; BREAST-CANCER;
   RADIOTHERAPY; COMPLEMENTARY; CARE; PAIN
AB Introduction: Acupuncture has potential as a supportive care service for cancer symptom management. However, little is known about patients' willingness to use acupuncture in the context of conventional cancer care.
   Methodology: We conducted a cross-sectional survey study among patients with cancer during their last week of fractionated/external beam radiotherapy (RT). The main outcome variable was self-reported likelihood of using acupuncture during RT. Knowledge about acupuncture and pain severity was measured along with socio-demographic and clinical variables. Multivariate logistic regression was performed to identify factors associated with willingness to use acupuncture.
   Results: Among the 305 participants, 79 (26.4%) were likely to use acupuncture during RT if such services were offered at a reasonable price, 143 (46.9%) had no knowledge of acupuncture, and 206 (67.6%) reported having pain. In multivariate analyses, non-Whites (adjusted odds ratio [AOR] 1.94, 95% confidence interval [CI] 1.06-3.56), and those with pain (AOR 2.52, CI 1.25-5.10) were more interested in using acupuncture. In addition, patients with preexisting knowledge about acupuncture were also more likely to use acupuncture than those without this knowledge (AOR 2.23, CI 1.28-3.88).
   Conclusions: Patients of non-White race, those with pain or those with prior knowledge about acupuncture were more willing to utilize acupuncture during RT. Since half of the patients had no knowledge about acupuncture, interventions to improve patients' knowledge are needed to facilitate the successful integration of acupuncture into cancer care. (C) 2014 Elsevier GmbH. All rights reserved.
C1 [Frankel, Eitan; Garland, Sheila; Mao, Jun J.] Univ Penn, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Garland, Sheila; Meghani, Salimah H.; Vapiwala, Neha; Mao, Jun J.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
   [Mao, Jun J.] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Meghani, Salimah H.] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
   [Vapiwala, Neha] Univ Penn, Dept Radiat Oncol, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania; University of Pennsylvania
RP Mao, JJ (corresponding author), Univ Penn, Dept Family Med & Community Hlth, 3400 Spruce St 2 Gates, Philadelphia, PA 19104 USA.
EM frankel4@uic.edu; sheila.garland@uphs.upenn.edu;
   meghanis@nursing.upenn.edu; vapiwala@uphs.upenn.edu;
   jun.mao@uphs.upenn.edu
RI Mao, Jun/F-5009-2012; Garland, Sheila/AGL-7759-2022; Vapiwala,
   Neha/ABG-4062-2021
OI Garland, Sheila/0000-0002-6119-318X; Meghani,
   Salimah/0000-0002-5866-8279
FU National Center for Complementary and Alternative Medicine grant [1K23
   AT004112-05]
FX National Center for Complementary and Alternative Medicine [1K23
   AT004112-05] grant.
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NR 28
TC 4
Z9 4
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD OCT
PY 2014
VL 6
IS 5
BP 532
EP 537
DI 10.1016/j.eujim.2014.06.007
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AR9UM
UT WOS:000343923800004
PM 25386224
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Su, WH
   Li, XL
   Wang, YR
AF Su, Wenhao
   Li, Xueling
   Wang, Yanru
TI Efficacy of pharmacological and non-pharmacological therapy on chronic
   cancer pain intensity of adults with cancer: A network meta-analysis
   protocol
SO PLOS ONE
LA English
DT Article
ID QUALITY-OF-LIFE; MANAGEMENT; ACUPUNCTURE; GUIDELINES; RELIEF
AB Background Chronic cancer pain is very common symptom in cancer patients, but this issue has not been satisfactorily resolved by the conventional three-step analgesic therapy. There are multiple non-pharmacological interventions for managing chronic cancer pain, but we haven't reached a consensus on which non pharmacological treatment is the best and these treatments are lack of high-quality evidence. In order to identify the most effective non-pharmaceutical therapy alternatives and investigate further possible medication interventions, this study will use network meta-analysis to assess the therapeutic effects of pharmacological and non-pharmacological treatments on chronic cancer pain patients and support clinical decision-making by prioritizing therapies according to the most valuable clinical outcomes for these patients.Methods and analysis We will carry out a systematic search of published randomized controlled trials (group, crossover, and parallel) in the PubMed, Web of Science, Cochrane Library, MEDLINE, Embase, and CINAHL databases, without language or date restrictions, in accordance with the PRISMA for Network Meta-Analyses (PRISMA-NMA) guidelines. Included studies must evaluate the effects of pharmacological and non-pharmacological treatments in patients with chronic cancer pain. Adult chronic cancer pain patients (>= 18 years old) receiving pharmacological or non-pharmacological treatment will be our target participants. Our primary outcomes will be pain intensity, total effective rate of treatment, onset time, and quality of Life (QoL); Adverse reaction will be our secondary outcome. We'll utilize the mean difference (MD) for continuous variables, the odds ratio (OR) for binary variables, and the 95% confidence interval (CI) for interval estimates. The Cochrane Bias Risk Tool (RoB2.0) will be used to assess the bias risk of every RCT trial included in NMA. We will use Review Manager 5.3 software to conduct heterogeneity testing and meta-analysis. The network meta-analysis will be performed by ADDIS1.16.8 software. The Confidence in Network Meta-analysis (CINeMA) framework will be used to evaluate the level of confidence in the NMA results. Besides, we will use SUCRA for ranking the network meta-analysis results, and we will also apply normalized entropy to verify the accuracy of the SUCRA ranking outcomes.Discussion This network meta-analysis will compare the efficacy of pharmacological versus non-pharmacological treatments for pain intensity in chronic cancer pain patients. The final analysis results may be significantly heterogeneous, because the population with cancerous pain suffers from different types of cancers. Owing to the databases primary reliance on our listed databases for inclusion, potentially valuable research will be overlooked.Registration This study has been registered in the PROSPERO database (CRD42024505214)
C1 [Su, Wenhao] Wenzhou Med Univ, Quzhou Peoples Hosp, Nursing Dept, Quzhou, Zhejiang, Peoples R China.
   [Li, Xueling] Hainan Vocat Univ Sci & Technol, Sch Nursing, Haikou, Hainan, Peoples R China.
   [Wang, Yanru] Zhejiang Chinese Med Univ, Sch Nursing, Hangzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Hainan Vocational University of Science &
   Technology; Zhejiang Chinese Medical University
RP Wang, YR (corresponding author), Zhejiang Chinese Med Univ, Sch Nursing, Hangzhou, Zhejiang, Peoples R China.
EM Wangyanru001@outlook.com
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NR 49
TC 0
Z9 0
U1 5
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2025
VL 20
IS 7
AR e0322651
DI 10.1371/journal.pone.0322651
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5SR7Z
UT WOS:001543410900003
PM 40674370
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Hao, YB
   Liu, YL
   Wang, XM
   Cheng, K
   Tu, QY
   Dai, F
   Yang, XB
AF Hao, Ya-bo
   Liu, Yan-lin
   Wang, Xiao-mei
   Cheng, Kai
   Tu, Qing-yu
   Dai, Fei
   Yang, Xi-bing
TI Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory
   Markers in IBS Rats
SO NEUROGASTROENTEROLOGY AND MOTILITY
LA English
DT Article; Early Access
DE electroacupuncture; inflammatory biomarkers; visceral hypersensitivity;
   visceral pain; Zusanli
ID ACUPUNCTURE; MECHANISMS; PATHWAY; MODEL
AB Background: Irritable bowel syndrome (IBS) is characterized by recurrent visceral pain associated with low-grade gut inflammation. Electroacupuncture (EA) at acupoint ST36 (Zusanli) is reputed to alleviate gastrointestinal disorders, but its effects on IBS-related visceral hypersensitivity and inflammation remain to be fully elucidated. This study evaluated whether EA at ST36 attenuates visceral pain and modulates key inflammatory mediators in the IBS rat model.
   Methods: Forty male rats were randomly assigned to Control, IBS model, IBS + EA, and IBS + Sham groups (n = 10 each). IBS was induced by intracolonic acetic acid enema combined with daily restraint stress for 1 week, validating the IBS-D model. EA was applied at bilateral ST36 (2/100 Hz alternating frequency, similar to 0.5 mA, 20 min) every other day for 2 weeks; sham treatment used superficial needling with no electrical current. Visceral pain was assessed by abdominal withdrawal reflex (AWR) scores and electromyographic responses to graded colorectal distension. Colonic tissues were analyzed for pro-inflammatory cytokines (interleukin-1 beta, IL-6, tumor necrosis factor-alpha) by ELISA and for the expression of pain or inflammation-related proteins (TRPV1 and nuclear factor kappa B, NF-kappa B) by Western blot analyses.
   Results: IBS model rats exhibited pronounced visceral hypersensitivity, with AWR scores significantly elevated (e.g., score 3 threshold volume reduced by similar to 40% vs. controls, p < 0.01). EA at ST36 markedly alleviated visceral pain, increasing pain threshold and reducing AWR scores by similar to 30%-50% compared to untreated IBS (p < 0.05). EA also significantly downregulated colonic IL-1 beta, IL-6, and TNF-alpha levels (by 45%-60% vs. IBS, p < 0.01) and reduced TRPV1 and NF-kappa B expression toward normal levels.
   Conclusion: EA at ST36 produced significant analgesic and anti-inflammatory effects in IBS model rats. Visceral hypersensitivity was blunted and colonic inflammatory biomarkers (cytokines, TRPV1, NF-kappa B) were suppressed by EA, suggesting that EA at ST36 modulates neuro-immune pathways to relieve IBS-related pain. These findings support the therapeutic potential of ST36-targeted electroacupuncture for managing IBS visceral pain via inflammatory mechanism attenuation.
C1 [Hao, Ya-bo; Liu, Yan-lin; Wang, Xiao-mei; Yang, Xi-bing] Jiaxing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Jiaxing, Zhejiang, Peoples R China.
   [Cheng, Kai] Jiaxing Hosp Tradit Chinese Med, Pediat Dept, Jiaxing, Zhejiang, Peoples R China.
   [Tu, Qing-yu] Jiaxing Hosp Tradit Chinese Med, Jiaxing, Zhejiang, Peoples R China.
   [Dai, Fei] Xi An Jiao Tong Univ, Affiliated Hosp 2, Div Gastroenterol, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Yang, XB (corresponding author), Jiaxing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Jiaxing, Zhejiang, Peoples R China.; Dai, F (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 2, Div Gastroenterol, Xian, Shaanxi, Peoples R China.
EM feifeili001@outlook.com; yxb821018@163.com
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1350-1925
EI 1365-2982
J9 NEUROGASTROENT MOTIL
JI Neurogastroenterol. Motil.
PD 2025 DEC 18
PY 2025
AR e70195
DI 10.1111/nmo.70195
EA DEC 2025
PG 14
WC Gastroenterology & Hepatology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Neurosciences & Neurology
GA Z7815
UT WOS:001642955500001
PM 41413920
OA hybrid
DA 2026-01-16
ER

PT J
AU Ludwick, A
   Corey, K
   Meghani, S
AF Ludwick, Allison
   Corey, Kristin
   Meghani, Salimah
TI Racial and Socioeconomic Factors Associated with the Use of
   Complementary and Alternative Modalities for Pain in Cancer Outpatients:
   An Integrative Review
SO PAIN MANAGEMENT NURSING
LA English
DT Review
ID AFRICAN-AMERICANS; MEDICINE USE; UNITED-STATES; CARE; SURVIVORS;
   ACUPUNCTURE; MANAGEMENT; ATTITUDES; ADHERENCE; BELIEFS
AB Objectives: Racial and ethnic disparities in pain management are widely documented in the United States. The 2016 Centers for Disease Control and Prevention (CDC) guidelines for opioid prescribing have generated new imperatives for using complementary and alternative medicine approaches (CAM) to manage chronic pain, including cancer pain. This review's purpose was to explore the prevalence of CAM use for cancer-related pain among racial and ethnic minorities and to organize these findings according to the CAM modalities proposed by the National Center for Complementary and Integrative Health (NCCIH).
   Design: An integrative review of the literature published between 2007 and 2017.
   Data Sources: PubMed and SCOPUS databases (2007-2017).
   Review/Analysis Methods: Articles were included if they engaged in explicit analysis of racial or ethnic differences in CAM use for cancer pain in the outpatient setting, yielding 13 articles for final analysis.
   Results and Conclusions: Overall, CAM use for any modality ranged from 51% to 83%. Mind-body therapies were reported most, and energy therapies the least. Differences in CAM use were most often attributable to socioeconomic status (SES), with those of higher SES associated with greater use of practitioner-assisted CAM therapies and those of lower SES with greater use of free therapies. This difference has implications for achieving adequate and consistent pain relief among subgroups of patients with cancer. This review also identifies a literature gap regarding racial/ethnic disparities in access to CAM for cancer pain, and a need for validated measures to assess CAM use. (C) 2019 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
C1 [Ludwick, Allison; Corey, Kristin; Meghani, Salimah] Univ Penn, Sch Nursing, Fagin Hall 337,418 Curie Blvd, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Ludwick, A (corresponding author), Univ Penn, Sch Nursing, Fagin Hall 337,418 Curie Blvd, Philadelphia, PA 19104 USA.
EM ludwicka@upenn.edu
OI Meghani, Salimah/0000-0002-5866-8279
FU National Institute of Nursing Research, National Institutes of Health
   [R01NR017853]; Ruth L. Kirschstein National Research Service Award
   training program Individualized Care for At Risk Older Adults at the
   University of Pennsylvania - National Institute of Nursing Research
   [T32NR009356]; National Institute of Nursing Research [R01NR017853,
   T32NR009356] Funding Source: NIH RePORTER
FX This research was not supported by any specific grant from funding
   agencies in the public, commercial, or not-for-profit sectors. Dr.
   Meghani is supported in part by the National Institute of Nursing
   Research, National Institutes of Health (R01NR017853). Dr. Kristin Corey
   acknowledges support from the Ruth L. Kirschstein National Research
   Service Award training program Individualized Care for At Risk Older
   Adults at the University of Pennsylvania, funded by National Institute
   of Nursing Research T32NR009356.
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NR 44
TC 24
Z9 27
U1 1
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD APR
PY 2020
VL 21
IS 2
BP 142
EP 150
DI 10.1016/j.pmn.2019.08.005
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KU7GS
UT WOS:000519882200004
PM 31928745
DA 2026-01-16
ER

PT J
AU Penati, R
   Vecchio, R
   Gatto, R
   Odone, A
   Deandrea, S
AF Penati, Rachele
   Vecchio, Riccardo
   Gatto, Roberto
   Odone, Anna
   Deandrea, Silvia
TI High Outcome-Reporting Bias in Randomized-Controlled Trials of
   Acupuncture for Cancer Chemotherapy-Induced Nausea and Vomiting: A
   Systematic Review and Meta-Epidemiological Study
SO CURRENT ONCOLOGY
LA English
DT Review
DE bias; complementary therapies; nausea; vomiting; chemotherapy;
   acupuncture therapy
ID ELECTROACUPUNCTURE; PAIN
AB Selective outcome-reporting bias refers to the selective reporting of a subset of study findings. This methodological limitation may occur in cancer-related acupuncture studies, where valid empirical studies on psychometric performance are still lacking. We assessed the risk of selective outcome reporting bias in studies published in English that were included in a systematic review on acupuncture for preventing cancer chemotherapy-induced nausea and vomiting. For each study, we searched for registry availability and, if present, assessed its validity. We described each study outcome (nausea, vomiting, or both) according to the following seven items: type of outcome, domain, specific measurement, specific metric, type of data, methods of aggregation, and timepoint unit and time. Eleven studies published between 1987 and 2019 in English were evaluated. Only four (36%) had a registry, of which only two were prospective and therefore considered valid. Discrepancies were found in the specific measurement of the outcome in two studies and in the specific metric. In many other cases, discrepancies were not evaluable due to missing information. No study reported complete outcomes as planned in the published protocol. Communication about the importance of prospective trial registration, including outcome details, should be enforced to reduce the risk of selective outcome reporting bias in oncology acupuncture studies.
C1 [Penati, Rachele] Valduce Hosp, Villa Beretta Rehabil Ctr, I-23845 Costa Masnaga, Italy.
   [Penati, Rachele; Gatto, Roberto; Deandrea, Silvia] Ctr So Wen ETS, I-20146 Milan, Italy.
   [Vecchio, Riccardo; Odone, Anna; Deandrea, Silvia] Univ Pavia, Dept Publ Hlth Expt & Forens Med, I-27100 Pavia, Italy.
C3 University of Pavia
RP Deandrea, S (corresponding author), Ctr So Wen ETS, I-20146 Milan, Italy.; Deandrea, S (corresponding author), Univ Pavia, Dept Publ Hlth Expt & Forens Med, I-27100 Pavia, Italy.
EM silvia.deandrea@unipv.it
RI ; Deanea, Silvia/AAS-1782-2021
OI Penati, Rachele/0000-0002-1684-3518; Odone, Anna/0000-0002-5657-9774;
   Vecchio, Riccardo/0000-0002-9702-8733; Deanea,
   Silvia/0000-0003-1509-951X
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NR 32
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1198-0052
EI 1718-7729
J9 CURR ONCOL
JI Curr. Oncol.
PD AUG 15
PY 2025
VL 32
IS 8
AR 462
DI 10.3390/curroncol32080462
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 6NC8D
UT WOS:001557308300001
PM 40862831
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Liu, JM
   Zhang, KQ
   Zhang, YY
   Ji, F
   Shi, HF
   Lou, Y
   Xu, H
AF Liu, Jianming
   Zhang, Keqin
   Zhang, Yongyan
   Ji, Feng
   Shi, Haifeng
   Lou, Yi
   Xu, Hua
TI Perioperative Transcutaneous Electrical Acupoint Stimulation Reduces
   Postoperative Pain in Patients Undergoing Thoracoscopic Surgery: A
   Randomized Controlled Trial
SO PAIN RESEARCH & MANAGEMENT
LA English
DT Article
ID ACUPUNCTURE; ELECTROACUPUNCTURE; TRANSITION; ANALGESIA; CANCER
AB Objectives. This study aimed to determine the effects of perioperative transcutaneous electrical acupoint stimulation (TEAS) on postoperative pain management in patients undergoing thoracic surgery. Methods. In the prospective, randomized, controlled study, a total of 84 patients undergoing video-assisted thoracoscopic surgery (VATS) were randomly allocated to the TEAS group (Group T) or control group (Group C). Patients in the Group T received TEAS at Neiguan (PC6) and Hegu (LI4) acupoints for 30 min before anesthesia induction and 30 min after thoracoscopic surgery. Patients in the Group C received the same placement of electrodes but without electrical stimulation. The numeric rating scale (NRS) pain score, remifentanil consumption, demand for rescue analgesics and incidence of postoperative nausea and vomiting (PONV), patient satisfaction, and the levels of plasma beta-endorphin (EP) and IL-6 were recorded. Results. Patients in the Group T had significantly lower NRS pain scores at 6 h, 12 h, 24 h, and 48 h after surgery than those in the Group C. Compared with Group C, patients in Group T had lower remifentanil consumption during operation, lower demand for rescue analgesics and lower rate of PONV within 24 h after surgery. Patients in Group T also had lower IL-6 content, higher beta-EP content and higher satisfaction degree than those in the Group C. Conclusions. Perioperative TEAS significantly decreased postoperative pain and rescued analgesia requirements and the incidence of PONV in patients undergoing thoracoscopic surgery, with a higher patient satisfaction. This trial is registered with ChiCTR2100051841.
C1 [Liu, Jianming; Zhang, Keqin; Zhang, Yongyan; Ji, Feng; Shi, Haifeng; Lou, Yi; Xu, Hua] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Anesthesiol, Shanghai 200437, Peoples R China.
   [Liu, Jianming] Tongji Univ, Pulm Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Tongji University
RP Lou, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Anesthesiol, Shanghai 200437, Peoples R China.
EM liujianming@126.com; karinzhangsh@163.com; zyy331679373@163.com;
   medicjifeng@163.com; 18016498116@163.com; louyijj877@sina.com;
   pshhuaxu@163.com
OI Zhang, Yongyan/0000-0001-6777-7808
FU National Natural Science Foundation of China [82074228]; Construction
   Project of Traditional Chinese Medicine Specialty in Yueyang Hospital
   [YW2023-2024-01-05]
FX We thank all those who support and participate in the study, including
   our staff, patients, and their family members. This study was funded by
   the National Natural Science Foundation of China (82074228) and
   Construction Project of Traditional Chinese Medicine Specialty in
   Yueyang Hospital (YW2023-2024-01-05).
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NR 30
TC 9
Z9 10
U1 2
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1203-6765
EI 1918-1523
J9 PAIN RES MANAG
JI Pain Res. Manag.
PD JUN 30
PY 2024
VL 2024
AR 5365456
DI 10.1155/2024/5365456
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA XS3L9
UT WOS:001263626500001
PM 38974755
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, JL
   Liu, CZ
   Zhang, N
   Yan, CQ
   Tu, JF
   Wang, LQ
   Qi, YS
   Liu, JH
   Wang, X
AF Li, Jin-Ling
   Liu, Cun-Zhi
   Zhang, Na
   Yan, Chao-Qun
   Tu, Jian-Feng
   Wang, Li-Qiong
   Qi, You-Sheng
   Liu, Jun-Hong
   Wang, Xu
TI Neurological and psychological mechanisms of the specific and
   nonspecific effects of acupuncture on knee osteoarthritis: study
   protocol for a randomized, controlled, crossover trial
SO TRIALS
LA English
DT Article
DE Acupuncture; Functional magnetic resonance imaging; Nonspecific effect;
   Psychological factors; Specific effect
ID SHAM ACUPUNCTURE; BREAST-CANCER; HOT FLASHES; BRAIN; PAIN; SCALE;
   MIGRAINE; WOMEN; ELECTROACUPUNCTURE; EXPECTANCY
AB Background: Acupuncture, as one of the promising non-pharmacological interventions, has been proved to be beneficial for patients. However, the magnitude of acupuncture's specific and nonspecific effects, as well as their neurological and psychological determinants, remains unclear. Therefore, this study is designed to examine the acupuncture efficacy, investigate whether the brain mechanisms between the specific and nonspecific effects of acupuncture are different, and to evaluate how psychological factors affect the acupuncture effects.
   Methods: This is a randomized, controlled, crossover clinical trial. A total of 60 patients with knee osteoarthritis will receive 4 weeks of acupuncture treatment and 4 weeks of sham acupuncture treatment in a random order separated by a washout period of 2 weeks. The changes in clinical characteristics based on pain-related scales will be assessed to investigate the clinical efficacy of acupuncture. Resting state functional magnetic resonance imaging (fMRI) scans will be used to identify the brain activity changes related to the specific and nonspecific effects of acupuncture. The questionnaires of psychological factors will be used to evaluate patients' psychological properties. Correlation and mediation analyses will be conducted among psychological factors, brain activity changes, and symptoms improvement to explore the neurological and psychological correlates of the acupuncture effects.
   Discussion: This study will concentrate on distinguishing and clarifying the specific and nonspecific effects of acupuncture. The results of this study may contribute to rationally optimize the acupuncture therapies by flexible application of the specific and nonspecific effects of acupuncture.
C1 [Li, Jin-Ling; Liu, Cun-Zhi; Zhang, Na; Yan, Chao-Qun; Tu, Jian-Feng; Wang, Li-Qiong] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Acupuncture Res Ctr, Beijing 100029, Peoples R China.
   [Qi, You-Sheng; Liu, Jun-Hong] Nanyuan Community Hlth Serv Ctr, Beijing 100076, Peoples R China.
   [Wang, Xu] Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Wang, X (corresponding author), Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.
EM wangx@bucm.edu.cn
RI li, jinling/HRD-0858-2023; Tu, Jian-Feng/J-7768-2017; Liu,
   Cunzhi/J-9190-2017
FU Beijing Municipal Science & Technology Commission [D171100003217003]
FX This work will be supported by Beijing Municipal Science & Technology
   Commission (D171100003217003). The funding plays no role in study
   design, collection, management, analysis, or interpretation of the data,
   or approval of the manuscript, or the decision to submit the manuscript
   for publication.
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NR 50
TC 4
Z9 6
U1 3
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 30
PY 2020
VL 21
IS 1
AR 989
DI 10.1186/s13063-020-04908-9
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PB4PK
UT WOS:000596304400004
PM 33256796
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ho, EY
   Thompson-Lastad, A
   Lam, R
   Zhang, XY
   Thompson, N
   Chao, MT
AF Ho, Evelyn Y.
   Thompson-Lastad, Ariana
   Lam, Rachele
   Zhang, Xiaoyu
   Thompson, Nicole
   Chao, Maria T.
TI Adaptations to Acupuncture and Pain Counseling Implementation in a
   Multisite Pragmatic Randomized Clinical Trial
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; pragmatic effectiveness; pain; cancer; implementation;
   inpatient
ID CANCER PAIN; INTERVENTIONS; MANAGEMENT; QUALITY
AB Objectives: As part of a pragmatic effectiveness trial of integrative pain management among inpatients with cancer, the authors sought to understand the clinical context and adaptations to implementation of two study interventions, acupuncture and pain counseling (i.e., pain education and coping skills).
   Design: The larger study uses a 2 x 2 factorial design with inpatients randomized to: (1) usual care (UC), (2) UC with acupuncture, (3) UC with pain counseling, and (4) UC with acupuncture and pain counseling. The study is being conducted in two hospitals (one academic and one public) and three languages (Cantonese, English, and Spanish). The authors conducted a process evaluation by interviewing study interventionists. Analysis included deductive coding to describe context, intervention, implementation, and inductive thematic coding related to intervention delivery.
   Results: Interviewees included seven acupuncturists and four pain counselors. Qualitative themes covered adaptations and recognizing site-specific differences that affected implementation. Interventionists adhered closely to protocols and made patient-centered adaptations that were then standardized in broader implementation (e.g., including caregivers in pain counseling sessions; working in culturally nuanced ways with non-English-speaking patients). The public hospital included more patients with recent diagnoses and advanced disease, more ethnically and linguistically diverse patients, less continuity of staffing, and shared patient rooms. At the academic medical center, more patients were familiar with integrative therapies and all were located in single rooms. Providing acupuncture to hospital staff was a key strategy to establish trust, experientially explain the intervention, and create camaraderie and staff buy-in.
   Conclusions: Providing nonpharmacologic interventions for a pragmatic trial requires adapting to a range of clinical factors. Site-specific factors included greater coordination and resources needed for successful implementation in the public hospital. The authors conclude that adaptation to context and individual patient needs can be done without compromising intervention fidelity and that intervention design should apply principles such as centering at the margins to reduce participation barriers for diverse patient populations.
C1 [Ho, Evelyn Y.] Univ San Francisco, Dept Commun Studies, 2130 Fulton St,KA 313, San Francisco, CA 94117 USA.
   [Ho, Evelyn Y.] Univ Calif San Francisco, Asian Amer Res Ctr Hlth, San Francisco, CA 94143 USA.
   [Thompson-Lastad, Ariana; Lam, Rachele; Zhang, Xiaoyu; Thompson, Nicole; Chao, Maria T.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA.
   [Thompson-Lastad, Ariana] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp & Trauma Ctr, Div Gen Internal Med, Dept Family & Community Med, San Francisco, CA 94143 USA.
   [Chao, Maria T.] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp & Trauma Ctr, Div Gen Internal Med, Dept Med, San Francisco, CA 94143 USA.
C3 University of San Francisco; University of California System; University
   of California San Francisco; University of California System; University
   of California San Francisco; University of California System; University
   of California San Francisco; University of California System; University
   of California San Francisco
RP Ho, EY (corresponding author), Univ San Francisco, Dept Commun Studies, 2130 Fulton St,KA 313, San Francisco, CA 94117 USA.
EM eyho@usfca.edu
RI Ho, Evelyn Y/AAE-6177-2020
OI Ho, Evelyn Y/0000-0001-8629-0122
FU Patient-Centered Outcomes Research Institute Award [CER-1609-36220];
   National Institutes of Health National Center for Complementary and
   Integrative Health [5T32AT003997]; Helen Diller Family Foundation;
   National Center for Complementary and Integrative Health [T32AT003997]
   Funding Source: NIH RePORTER
FX Research reported in this publication was partially funded through a
   Patient-Centered Outcomes Research Institute Award (CER-1609-36220).
   Additional support was provided by the National Institutes of Health
   National Center for Complementary and Integrative Health (Award
   #5T32AT003997) and the Helen Diller Family Foundation.
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NR 26
TC 4
Z9 5
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY 1
PY 2021
VL 27
IS 5
BP 398
EP 406
DI 10.1089/acm.2020.0387
EA APR 2021
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SD2FV
UT WOS:000644199100001
PM 33902333
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Pei, P
   Cui, SW
   Zhang, SS
   Hu, S
   Wang, LP
   Yang, WM
AF Pei, Pei
   Cui, Shengwei
   Zhang, Shuaishuai
   Hu, Sheng
   Wang, Linpeng
   Yang, Wenming
TI Effect of Electroacupuncture at Fengchi on Facial Allodynia, Microglial
   Activation, and Microglia-Neuron Interaction in a Rat Model of Migraine
SO BRAIN SCIENCES
LA English
DT Article
DE electroacupuncture; migraine; microglia; inflammatory cytokines
ID CUTANEOUS ALLODYNIA; TRIGEMINOVASCULAR PATHWAY; PAIN; SENSITIZATION;
   PATHOPHYSIOLOGY; CONTRIBUTE; MODULATION; EXPRESSION; HEADACHE; SYSTEM
AB The purpose of the work was to investigate whether electroacupuncture (EA) could ameliorate migraine central sensitization by modulating microglial activation and the subsequent release of inflammatory cytokines in the trigeminal nucleus caudalis (TNC) in a rat model. Establishment of a rat model of recurrent migraine was achieved through repeated dural electrical stimulation (DES). After nine sessions of acupuncture treatment at Fengchi (GB20), facial mechanical thresholds were measured by electronic von Frey measurements. Microglial activation and cytokine receptors of TNC were evaluated by immunofluorescence staining. The expression of microglial biological marker Ibal-1, proinflammatory cytokines, and cytokine receptors in the TNC were evaluated by Western blot and/or real-time polymerase chain reaction. In addition, the effects of inhibition of microglial activation on facial thresholds and neuronal activation (i.e., expression of c-Fos in the TNC) induced by DES were observed. After consecutive EA-GB20 treatments, the facial withdrawal threshold was significantly higher than in the model group at different time points (p < 0.05). The hyperreactivity of microglia induced by DES was significantly inhibited, and the expressions of Ibal-1, interleukin-1 beta, tumor necrosis factor-alpha, and their receptors in the TNC were also significantly decreased (p < 0.05). Inhibition of microglia by minocycline demonstrated an acupuncture-like role, which was manifested by ameliorated mechanical hyperalgesia and decreased neuronal expression of c-Fos, Iba-1, and inflammatory factors. EA at GB20 could ameliorate migraine facial allodynia by inhibiting microglial activation and the subsequent release of inflammatory cytokines and their receptors in the TNC.
C1 [Pei, Pei; Yang, Wenming] Anhui Univ Chinese Med, Affiliated Hosp 1, Neurol Dept, Hefei 230031, Peoples R China.
   [Cui, Shengwei; Zhang, Shuaishuai; Hu, Sheng] Anhui Univ Chinese Med, 350 Longzihu Rd, Hefei 230012, Peoples R China.
   [Wang, Linpeng] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Beijing 100010, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui University of Chinese
   Medicine; Capital Medical University
RP Yang, WM (corresponding author), Anhui Univ Chinese Med, Affiliated Hosp 1, Neurol Dept, Hefei 230031, Peoples R China.; Wang, LP (corresponding author), Capital Med Univ, Beijing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Beijing 100010, Peoples R China.
EM wanglinpeng@bjzhongyi.com; yangwm8810@126.com
RI ; zhang, shuai/IVU-7877-2023; Hu, Shenglin/GSE-4508-2022
OI ShengWei, Cui/0000-0001-8163-7318; pei, pei/0000-0002-4479-2391; 
FU National Natural Science Foundation of China [81973825]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81803903) and National Natural Science Foundation of China
   (No. 81973825).
CR Aczél T, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082938
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NR 36
TC 10
Z9 12
U1 1
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD AUG
PY 2022
VL 12
IS 8
AR 1100
DI 10.3390/brainsci12081100
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4C0TT
UT WOS:000846178200001
PM 36009163
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lukkahatai, N
   Benjasirisan, C
   Shen, AM
   Li, JX
   Allgood, S
   Thomas, F
   Karyukin, A
   Sheng, JY
   Engle, J
   Lee, TY
   Saligan, LN
AF Lukkahatai, Nada
   Benjasirisan, Chitchanok
   Shen, Aomei
   Li, Junxin
   Allgood, Sarah
   Thomas, Frank
   Karyukin, Artyom
   Sheng, Jennifer Y.
   Engle, Jessica
   Lee, Ta-Ya
   Saligan, Leorey N.
TI Combined technology-enhanced home exercise and acupressure (TEHEplus)
   program on symptoms among cancer patients receiving immunotherapy: a
   feasibility study
SO BMC CANCER
LA English
DT Article
DE Cancer; Immunotherapy; Exercise; Acupressure; Mobile health
ID PHYSICAL-ACTIVITY; INTERVENTION; RELIABILITY; MANAGEMENT; THERAPY;
   FATIGUE; HEALTH; SLEEP; LUNG
AB BackgroundCancer patients receiving immunotherapy often experience symptoms impacting their well-being. The present study aimed to develop and test the feasibility of a 12-week Technology-Enhanced Home Exercise and acupressure (TEHEplus) program to improve symptoms (fatigue, pain, sleep, anxiety, depression), social functioning, physical performance, and serum biomarkers (brain-derived neurotrophic factor, heat shock protein 90 levels.)MethodsA two-phase design was employed. Phase 1 involved program development; Phase 2 was a pilot feasibility study. Participants with solid tumor cancers were recruited from cancer centers in Maryland and randomly assigned to four groups: Usual Care Control (UC), Technology-Enhanced Home Exercise (TEHE) alone, Acupressure alone (ACU), and TEHEplus. Feasibility was measured by enrollment duration, intervention adherence, and daily survey response rates. Outcomes were measured at baseline and program completion.ResultsIn phase 1, four participants (age 56-82) provided feedback on online training, smartphone application, intervention duration, and outcome measures. In Phase 2, 40 participants (10 per group) were recruited over 12 months, with 43% (n = 17) completing all daily surveys. TEHEplus participants achieved 50% of exercise goals, and 78% adhered to the acupoint recommendations. TEHEplus participants showed significant improvements in fatigue (p = 0.02), pain inference (p = 0.30), and social functioning (p = 0.03); TEHE participants improved only in social functioning (p = 0.03).ConclusionTEHEplus is feasible and shows promise for symptom alleviation. Preliminary findings suggest potential benefits in symptom management and functional outcomes. However, further studies with larger and more diverse samples are warranted to explore its efficacy and generalizability.Further studies with larger, more diverse populations are needed to confirm its efficacy. TEHEplus may enhance symptom management and improve functional outcomes for cancer survivors undergoing immunotherapy.Trial registrationClinicalTrials.gov ID NCT03576274 Trial Registration Date: 06/07/2018.
C1 [Lukkahatai, Nada; Benjasirisan, Chitchanok; Li, Junxin; Allgood, Sarah; Thomas, Frank; Karyukin, Artyom] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
   [Shen, Aomei] Tianjin Med Univ, Natl Clin Res Ctr Canc, Canc Inst & Hosp, Minist Educ, Tianjin, Peoples R China.
   [Sheng, Jennifer Y.; Engle, Jessica; Lee, Ta-Ya] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
   [Saligan, Leorey N.] Rutgers State Univ, Sch Nursing, Newark, NJ USA.
C3 Johns Hopkins University; Tianjin Medical University; Johns Hopkins
   University; Johns Hopkins Medicine; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Newark
RP Lukkahatai, N (corresponding author), Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
EM nada.lukkahatai@jhu.edu; cbenjas1@jh.edu; shenaomei0239@gmail.com;
   junxin.li@jhu.edu; sallgoo1@jhmi.edu; fthoma12@jhmi.edu;
   adk2187@cumc.columbia.edu; jsheng7@jhmi.edu; jengli18@jhmi.edu;
   tlee19@jhmi.edu; ls1684@sn.rutgers.edu
RI Saligan, Leorey/M-7101-2015; Thomas, Frank/H-8418-2019; Benjasirisan,
   Chitchanok/KVB-0474-2024; Lukkahatai, Nada/GQA-9711-2022
OI Engle, Jessica/0000-0002-4711-7324; Sheng, Jennifer/0000-0002-4513-4235;
   Benjasirisan, Chitchanok/0000-0001-6465-0721; Allgood,
   Sarah/0000-0003-0259-6613; Li, Junxin/0000-0001-9798-5456; Lukkahatai,
   Nada/0000-0003-3820-1812
FU Oncology Nursing Foundation
FX We extend our sincere gratitude to all cancer survivors who generously
   agreed to participate in this study, and to the research assistants and
   clinical staff whose efforts in referral and recruitment made this work
   possible. We also acknowledge Mr. Natthapon Sricort and his team at Leaf
   Software and Production Co. Ltd., Thailand, for their expertise and
   consultation support in developing and maintaining the TEHEplus
   platform.
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NR 59
TC 0
Z9 0
U1 5
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD OCT 1
PY 2025
VL 25
IS 1
AR 1481
DI 10.1186/s12885-025-14887-2
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 8EH4L
UT WOS:001586617000001
PM 41034793
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yeh
   Chien, L
   Glick, R
   van Londen, G
   Bovbjerg, D
AF Yeh
   Chien, L.
   Glick, R.
   van Londen, G.
   Bovbjerg, D.
TI Auricular point acupressure to manage symptom clusters of pain, fatigue,
   and disturbed sleep in breast cancer patients
SO JOURNAL OF PAIN
LA English
DT Meeting Abstract
C1 [Yeh; Chien, L.; Glick, R.; van Londen, G.; Bovbjerg, D.] Univ Pittsburgh, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
NR 0
TC 1
Z9 1
U1 0
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD APR
PY 2015
VL 16
IS 4
SU 1
MA 538
BP S110
EP S110
DI 10.1016/j.jpain.2015.01.459
PG 1
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CF7PK
UT WOS:000352748600439
DA 2026-01-16
ER

PT J
AU Bao, T
   Li, SSQ
   Dearing, JL
   Piulson, LA
   Seluzicki, CM
   Sidlow, R
   Mao, JJ
AF Bao, Ting
   Li, Susan Q.
   Dearing, Josh L.
   Piulson, Lauren A.
   Seluzicki, Christina M.
   Sidlow, Robert
   Mao, Jun J.
TI Acupuncture versus medication for pain management: a cross-sectional
   study of breast cancer survivors
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE acupuncture; pain management; complementary medicine; oncology
ID ALTERNATIVE MEDICINE USE; AROMATASE INHIBITORS; COST-EFFECTIVENESS;
   RANDOMIZED-TRIAL; PERSISTENT PAIN; JOINT SYMPTOMS; RISK-FACTORS;
   COMPLEMENTARY; PREVALENCE; WOMEN
AB Aim of the study Breast cancer survivors who take aromatase inhibitors (AI) often suffer from chronic pain. Emerging evidence supports the use of acupuncture as an effective pain management strategy for this condition, but its acceptability among cancer survivors is unknown. We evaluated breast cancer survivors' preferences for acupuncture as compared with medication use and identified factors predictive of this preference.
   Methods We conducted a cross-sectional study among breast cancer survivors who were currently, or had been, taking an AI. The primary outcome was degree of preference for acupuncture as compared with medication for pain management. We conducted multivariate logistic regression analyses to evaluate the effects of socioeconomic status (SES) factors and health beliefs on treatment preference.
   Results Among 592 participants, 160 (27.0%) preferred acupuncture, 153 (25.8%) preferred medication and 279 (47.1%) had no clear preference. In a multivariate analysis that only included SES, higher education and white race were significantly associated with greater preference for acupuncture. When health beliefs were added, SES effects were attenuated, while greater expectation of acupuncture's effect, lower perceived barriers to its use, higher social norm (endorsement from family members and healthcare professionals) related to acupuncture and higher holistic health beliefs were associated with greater preference for acupuncture.
   Conclusion We found similar rates of preference for acupuncture versus medication among breast cancer survivors for pain management. Specific attitudes and beliefs predicted such preferences, highlighting the importance of a patient-centred approach to align patient beliefs and preferences with therapeutic options for more effective pain management.
   Trial registration number
   NCT01013337; Results.
C1 [Bao, Ting; Li, Susan Q.; Dearing, Josh L.; Piulson, Lauren A.; Seluzicki, Christina M.; Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1275 York Ave, New York, NY 10021 USA.
   [Sidlow, Robert] Mem Sloan Kettering Canc Ctr, Div Survivorship & Support Care, 1275 York Ave, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center
RP Bao, T (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med & Breast Med Serv, 1275 York Ave, New York, NY 10021 USA.
EM baot@mskcc.org
OI Bao, Ting/0000-0003-4437-2597; Piulson, Lauren/0000-0001-7034-3445;
   Seluzicki, Christina/0000-0002-8553-6810
FU National Cancer Institute [R01CA158243, R21CA173263]; Memorial Sloan
   Kettering Cancer Center P30 grant [P30-CA008748]; Byrne Fund at Memorial
   Sloan Kettering Cancer Center; National Cancer Institute [P30CA008748]
   Funding Source: NIH RePORTER
FX This study was funded in part by a National Cancer Institute R01CA158243
   (JJM) and R21CA173263 (TB), a Memorial Sloan Kettering Cancer Center P30
   grant (P30-CA008748), and the Byrne Fund at Memorial Sloan Kettering
   Cancer Center. The funding sources had no involvement in study design;
   collection, analysis and interpretation of data; writing of the report;
   or decision to submit the article for publication.
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NR 31
TC 26
Z9 28
U1 0
U2 33
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD APR
PY 2018
VL 36
IS 2
BP 80
EP 87
DI 10.1136/acupmed-2017-011435
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GC4CB
UT WOS:000429729700003
PM 29440043
OA Bronze
DA 2026-01-16
ER

PT J
AU Efverman, A
AF Efverman, Anna
TI Implementation of Acupuncture in Routine Oncology Care: A Comparison of
   Physicians', Nurses', Physiotherapists' and Acupuncturists' Practice and
   Beliefs
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE integrative medicine; nursing; integrative oncology; acupuncture;
   evidence-based care; attitudes; expectations; physiotherapy
ID BREAST-CANCER SURVIVORS; ALTERNATIVE MEDICINE; PLACEBO-ACUPUNCTURE;
   INDUCED NAUSEA; HOT FLASHES; COMPLEMENTARY; CHEMOTHERAPY; MANAGEMENT;
   EFFICACY; ELECTROACUPUNCTURE
AB Background:It is important to investigate beliefs in acupuncture in professionals because professionals' expectations may affect treatment outcomes. Aim:To document the type, number, and education of professionals practicing acupuncture. Further, to compare beliefs about the effectiveness of acupuncture for common cancer related symptoms in the different types of professionals. Methods:This cross-sectional study employed a questionnaire on practice and beliefs regarding acupuncture effects for symptoms that commonly occur in patients treated within oncology care settings. The respondents (n = 555) consisted of oncology professionals that is, physicians (n = 133), nurses (n = 172), and physiotherapists (n = 117). Additional respondents consisted of acupuncturists (n = 133), working outside approved health care. Results:Of the respondents, acupuncture was practiced by 4% of the physicians, 6% of the nurses, 58% of the physiotherapists, and 90% of the acupuncturists. The professionals believed acupuncture to be effective for pain (of the physicians, nurses, physiotherapists, and acupuncturists, 94%, 98%, 89%, and 99% respectively believed in the effectiveness), chemotherapy-induced nausea (corresponding figures: 74%, 89%, 89%, and 93%), and vasomotor symptoms (corresponding figures: 71%, 81%, 80%, and 97%). The physicians believed acupuncture to be effective in a mean of 5 symptoms, nurses in 6 symptoms, physiotherapists in 6 symptoms, and acupuncturists in 10 symptoms (P < .001). Conclusions:Since the professionals varied substantially regarding practice, education and beliefs in acupuncture, oncology clinics may consider delivering patient preferred acupuncture according to evidence-informed guidelines rather than on varying preferences among the professionals, since professionals' treatment expectations may modify treatment outcomes.
C1 [Efverman, Anna] Univ Gavle, Gavle, Sweden.
   [Efverman, Anna] Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
C3 University of Gavle; University of Gavle
RP Efverman, A (corresponding author), Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
EM anna.efverman@hig.se
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NR 45
TC 2
Z9 2
U1 1
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PY 2022
VL 21
DI 10.1177/15347354221132834
PG 10
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 7K3MN
UT WOS:000905190300016
PM 36398874
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Tian, H
   Luo, Q
   Huang, LY
   Chen, G
   Sun, MS
   Liang, FR
AF Tian, Hao
   Luo, Qin
   Huang, Liuyang
   Chen, Guang
   Sun, Mingsheng
   Liang, Fanrong
TI Exploration of the quantitative-effectiveness association between
   acupuncture temporal parameters and chemotherapy-induced peripheral
   neuropathy in cancer patients: a dose-response meta-analysis of
   randomized controlled trials
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE acupuncture; chemotherapy-induced peripheral neuropathy; pain
   management; meta-analysis; dose-response
ID ELECTROACUPUNCTURE
AB Background Chemotherapy-induced peripheral neuropathy (CIPN) is one of the commonly reported symptoms impacting cancer survivors. This study evaluated and compared the effectiveness of acupuncture treatments for CIPN. Methods We searched six databases from their inception to August 2024 to identify eligible randomized controlled trials (RCTs). Primary outcome were pain scores. Secondary outcomes were quality of life including FACT/GOG-Ntx and EORTC QLQ-C30. The robust error meta-regression (REMR) method was used to evaluate the dose-response relationship across treatment parameters, including number of sessions, frequency, and duration. Results In total, 11 RCTs featuring 740 participants were included. The meta-analysis demonstrated that the primary analysis achieved a significant reduction in pain scores, with a standardized mean difference of [SMD= -1.23, 95% CI = (-2.22, -0.24); P < 0.01; I-2 = 95%], improvement quality of life including FACT/GOG-Ntx [SMD = 0.95, 95% CI = (0.02, 1.88); P < 0.01; I-2 = 93%] and EORTC QLQ-C30 [SMD = 0.36, 95% CI = (0.03, 0.68); P = 0.14; I-2 = 46%]. The nonlinear dose-response analysis suggests that pain improvement achieves the MCID at 16 treatment sessions, over 8 weeks, with a frequency of twice per week. Furthermore, analysis of the treatment duration chart shows that acupuncture maintains therapeutic effects during the follow-up period. Sensitivity analysis confirmed the robustness of these findings. Conclusion Acupuncture demonstrates significant potential in managing CIPN, particularly through individualized treatment regimens. The identified time-dose-response relationship suggests that tailoring acupuncture frequency and duration can to optimize pain relief in CIPN patients. Future high-quality studies and large-scale multicenter clinical trials are needed to validate these findings.
C1 [Tian, Hao; Chen, Guang; Sun, Mingsheng; Liang, Fanrong] Chengdu Univ Tradit Chinese Med, Clin Res Ctr Acupuncture & Moxibust Sichuan Prov, Coll Acupuncture & Tuina, Teaching Hosp 3,Coll Basic Med,Coll Int Educ, Chengdu, Sichuan, Peoples R China.
   [Luo, Qin] Sichuan Prov Orthoped Hosp, Dept Rheumatol & Orthoped, Chengdu, Sichuan, Peoples R China.
   [Huang, Liuyang] Hubei Univ Chinese Med, Coll Acupuncture & Orthoped, Wuhan, Peoples R China.
   [Huang, Liuyang] Hubei Univ Chinese Med, Hubei Prov Collaborat Innovat Ctr Prevent Treatmen, Wuhan, Peoples R China.
   [Huang, Liuyang] Hubei Univ Chinese Med, Hubei Shizhen Lab, Wuhan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Hubei University of
   Chinese Medicine; Hubei University of Chinese Medicine; Hubei University
   of Chinese Medicine
RP Sun, MS; Liang, FR (corresponding author), Chengdu Univ Tradit Chinese Med, Clin Res Ctr Acupuncture & Moxibust Sichuan Prov, Coll Acupuncture & Tuina, Teaching Hosp 3,Coll Basic Med,Coll Int Educ, Chengdu, Sichuan, Peoples R China.
EM sunmingsheng@cdutcm.edu.cn; acuresearch@126.com
RI Chen, Guang/LFU-4007-2024
FU National Natural Science Foundation of China [U21A20404]; Sichuan
   Provincial Department of Science and Technology Project, China
   [2021YFS0087]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the National Natural Science Foundation of China (grant: U21A20404),
   Sichuan Provincial Department of Science and Technology Project, China
   (grant: 2021YFS0087).
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NR 40
TC 1
Z9 1
U1 5
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD FEB 12
PY 2025
VL 14
AR 1527331
DI 10.3389/fonc.2024.1527331
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA Z0Z5D
UT WOS:001436293600001
PM 40034252
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhao, YX
   Yu, XC
   Gao, JH
   Yao, MJ
   Zhu, B
AF Zhao, Yu-Xue
   Yu, Xiao-Chun
   Gao, Jun-Hong
   Yao, Ming-Jiang
   Zhu, Bing
TI Acupuncture for Paclitaxel-Induced Peripheral Neuropathy: A Review of
   Clinical and Basic Studies
SO JOURNAL OF PAIN RESEARCH
LA English
DT Review
DE paclitaxel; peripheral neuropathy; acupuncture
ID BEE VENOM ACUPUNCTURE; POTENTIAL VANILLOID 1; DORSAL-ROOT GANGLION;
   MECHANICAL ALLODYNIA; GENE-EXPRESSION; CHEMOTHERAPY; PAIN;
   ELECTROACUPUNCTURE; ACTIVATION; CANCER
AB Paclitaxel-induced peripheral neuropathy (PIPN) is a common and intractable side effect of the conventional chemotherapeutic agent paclitaxel. Acupuncture has been reported as an effective alternative therapy in treatment of PIPN in both basic studies and clinical trials. However, there is a lack of comprehensive surveys to summarize the action of acupuncture in management of PIPN. In this review, we briefly demonstrate the basic pathology of PIPN, which includes the activation of ion channels, mitochondrial dysfunction, disruption of axonal transport and also neuro-inflammatory involvement. Meanwhile, we review both the clinical and basic studies as an emphasis to give a general overview of the therapeutic effect of acupuncture against PIPN. Finally, we summarize the current known mechanisms underlying the action of acupuncture against PIPN mainly at peripheral and spinal levels, which include various neurotransmitters, multiple receptors, different types of enzymes and molecules. In conclusion, acupuncture could be considered as a potential alternative therapy in treatment of PIPN, and further clinical and experimental studies are called for in the future.
C1 [Zhao, Yu-Xue; Yu, Xiao-Chun; Gao, Jun-Hong; Zhu, Bing] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, 16 Dong Zhi Men Nei South St, Beijing 100700, Peoples R China.
   [Yao, Ming-Jiang] China Acad Chinese Med Sci, Inst Basic Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China.
   [Yao, Ming-Jiang] Key Lab Pharmacol Chinese Mat Med, Beijing 100091, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Acupuncture &
   Moxibustion, CACMS; Xiyuan Hospital, CACMS; China Academy of Chinese
   Medical Sciences
RP Zhao, YX; Zhu, B (corresponding author), China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, 16 Dong Zhi Men Nei South St, Beijing 100700, Peoples R China.
EM claricezhao@live.cn; zhubing@mail.cintcm.ac.cn
FU Beijing Natural Science Foundation [7202141]; Fundamental Research Funds
   for the Central Public Welfare Research Institutes [201814009,
   ZZ13-YQ-067]; National Natural Science Foundation of China [81202763,
   81674075]
FX This work was supported by Beijing Natural Science Foundation (7202141
   to Y.-X. Z.), Fundamental Research Funds for the Central Public Welfare
   Research Institutes (201814009 and ZZ13-YQ-067 to Y.-X. Z.) and National
   Natural Science Foundation of China Research Grants (81202763 to Y.-X.
   Z., 81674075 to B.Z.).
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NR 90
TC 5
Z9 6
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2021
VL 14
BP 993
EP 1005
DI 10.2147/JPR.S296150
PG 13
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA RN4HZ
UT WOS:000640313900001
PM 33883931
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Huang, MC
   Chang, SC
   Liao, WL
   Ke, TW
   Lee, AL
   Wang, HM
   Chang, CP
   Yen, HR
   Chang, HH
   Chen, WTL
AF Huang, Ming-Cheng
   Chang, Sheng-Chi
   Liao, Wen-Ling
   Ke, Tao-Wei
   Lee, Ai-Lin
   Wang, Hwei-Ming
   Chang, Che-Pin
   Yen, Hung-Rong
   Chang, Hen-Hong
   Chen, William Tzu-Liang
TI Acupuncture May Help to Prevent Chemotherapy-Induced Peripheral
   Neuropathy: A Randomized, Sham-Controlled, Single-Blind Study
SO ONCOLOGIST
LA English
DT Article
DE acupuncture; chemotherapy; peripheral neuropathy; prevention; colorectal
   cancer; oxaliplatin
ID QUALITY-OF-LIFE; OXALIPLATIN-INDUCED-NEUROPATHY; COLORECTAL-CANCER;
   ADJUVANT TREATMENT; TRIAL; ELECTROACUPUNCTURE; NEUROTOXICITY;
   FLUOROURACIL; ASSOCIATION; DISTURBANCE
AB Objective This study investigated the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC).
   Methods This single center, randomized, controlled, single-blind clinical trial randomly assigned patients with stage 3 CRC attending outpatient clinics in China Medical University Hospital to either verum or sham acupuncture treatment concurrently with chemotherapy. Primary outcomes were nerve conduction velocity (NCV) and touch thresholds of limb terminals. Secondary outcomes were total and subdomain scores on the Functional Assessment of Cancer Therapy-General (FACT-G), and scores on the FACT/GOG-Ntx subscale and the Brief Pain Inventory-Short Form (BPI-SF), at baseline, weeks 12, 36, and follow-up (week 48).
   Results Thirty-two patients met the inclusion criteria and received verum acupuncture (N = 16) or sham acupuncture (N = 16). Under the intent-to-treat principle, 26 participants were analyzed. Significant changes from baseline for questionnaire scores and sensory NCV were observed in both study groups. Sham acupuncture was associated with significant reductions from baseline in motor NCV and sensory touch thresholds; no such changes were observed with verum acupuncture. No serious adverse events were reported.
   Conclusion Prophylactic acupuncture may exert neuroprotective effects on mechanical or tactile touch thresholds during chemotherapy regimens in patients with CRC, with evidence of this protectiveness persisting at 6 months' follow-up. The lack of change in motor NCV values with verum acupuncture indicates neuroprotective effects. Sensory NCV values and patient-reported outcomes did not differ significantly between the study groups.
C1 [Huang, Ming-Cheng] China Med Univ, Grad Inst Chinese Med, Sch Chinese Med, Coll Chinese Med, Taichung, Taiwan.
   [Huang, Ming-Cheng; Chang, Che-Pin; Yen, Hung-Rong; Chang, Hen-Hong] China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Chang, Sheng-Chi; Ke, Tao-Wei; Chen, William Tzu-Liang] China Med Univ Hosp, Div Colorectal Surg, Dept Surg, Taichung, Taiwan.
   [Liao, Wen-Ling; Chang, Hen-Hong] China Med Univ, Grad Inst Integrated Med, Coll Chinese Med, 91 Xueshi Rd, Taichung 40402, Taiwan.
   [Liao, Wen-Ling] China Med Univ Hosp, Dept Med Res, Ctr Personalized Med, Taichung, Taiwan.
   [Lee, Ai-Lin] All Ease Tradit Chinese Med Clin, Taichung, Taiwan.
   [Yen, Hung-Rong] China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung, Taiwan.
   [Yen, Hung-Rong; Chang, Hen-Hong] China Med Univ, Chinese Med Res Ctr, Taichung, Taiwan.
   [Yen, Hung-Rong] Asia Univ, Dept Biotechnol, Taichung, Taiwan.
   [Chen, William Tzu-Liang] China Med Univ, Dept Surg, Sch Med, Taichung, Taiwan.
   [Chen, William Tzu-Liang] China Med Univ, Dept Surg, Div Colorectal Surg, Hsinchu Hosp, Zhu Bei, Taiwan.
   [Ke, Tao-Wei] China Med Univ, Coll Chinese Med, Taichung, Taiwan.
   [Wang, Hwei-Ming] China Med Univ Hosp, Dept Surg, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; China Medical University Taiwan; China Medical
   University Taiwan; Asia University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan
RP Chang, HH (corresponding author), China Med Univ, Grad Inst Integrated Med, Coll Chinese Med, 91 Xueshi Rd, Taichung 40402, Taiwan.; Chen, WTL (corresponding author), China Med Univ Hosp, 2 Yude Rd, Taichung 404332, Taiwan.
EM tcmchh55@gmail.com; golfoma22@gmail.com
RI Huang, Ming-Cheng/GRY-5937-2022; Chang, Hen-Hong/ITT-2813-2023; Chang,
   chepin/JAO-4254-2023; Yen, Hung-Rong/M-1373-2013; Chen, William
   Tzu-Liang/ABA-5673-2021
OI Huang, Ming-Cheng/0000-0003-0830-7093; Chang,
   Hen-Hong/0000-0002-7840-1504; Chang, chepin/0000-0001-8901-4422; Yen,
   Hung-Rong/0000-0002-0131-1658; 
FU China Medical University Hospital [DMR-111-194]; "Chinese Medicine
   Research Center, China Medical University" from The Featured Areas
   Research Center Program by the Ministry of Education (MOE) in Taiwan
   [CMRC-CMA-6]
FX This work was financially supported by China Medical University Hospital
   (DMR-111-194) and the "Chinese Medicine Research Center, China Medical
   University" from The Featured Areas Research Center Program within the
   framework of the Higher Education Sprout Project by the Ministry of
   Education (MOE) in Taiwan (CMRC-CMA-6).
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NR 43
TC 14
Z9 16
U1 7
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD JUN
PY 2023
VL 28
IS 6
BP E436
EP E447
DI 10.1093/oncolo/oyad065
EA MAR 2023
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA P0ZN0
UT WOS:000952698500001
PM 36971468
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jung, MS
   Kim, M
   Sohn, EH
   Lee, JS
AF Jung, Mi Sook
   Kim, Mijung
   Sohn, Eun Hee
   Lee, Jin Sun
TI The Effectiveness and Safety of Nurse-Led Auricular Acupressure on
   Chemotherapy-Induced Peripheral Neuropathy Among Patients With Breast
   Cancer
SO CANCER NURSING
LA English
DT Article; Early Access
DE Auriculotherapy; Breast neoplasms; Drug toxicity; Peripheral nervous
   system disease
ID POINT ACUPRESSURE; OUTCOME MEASURES; PAIN; NEUROTOXICITY; ACUPUNCTURE;
   PREVALENCE; PREVENTION; MANAGEMENT; CONSENSUS; TOXICITY
AB Background Chemotherapy-induced peripheral neuropathy (CIPN) is a major symptom of distress among chemotherapy-treated cancer survivors. Although various interventions have been attempted, there is no criterion-standard treatment.
   Objective The aim of this study was to examine the efficacy and safety of auricular acupressure (AA) in improving peripheral neuropathy symptoms in breast cancer patients undergoing taxane-based treatment.
   Methods A total of 51 eligible participants were enrolled and randomly allocated (1:1) to AA or sham control groups. The intervention was performed weekly for 3 weeks using different ear points, depending on the group. The Total Neuropathy Score was used to measure CIPN objectively. The Numerical Rating Scale and the European Organization for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy-20 were used to measure the subjective symptoms of CIPN. Outcomes were compared between groups by time interaction using generalized estimating equations based on the intention-to-treat principle.
   Results Only 1 participant dropped out because of nausea and mild fever. The results of generalized estimating equations showed significant improvement in Numerical Rating Scale scores on the hands and feet and total Chemotherapy-Induced Peripheral Neuropathy-20 in the experimental group compared with the sham control group (all Ps < .05). Although the experimental group showed a greater reduction in Total Neuropathy Score scores than the sham control group, no significant differences were found.
   Conclusion Auricular acupressure is an effective and safe nurse-led intervention for managing CIPN symptoms in breast cancer patients.
   Implications for Practice The findings help nurses to integrate AA easily and usefully into nursing care, contributing to managing symptoms of CIPN in cancer patients and survivors.
C1 [Jung, Mi Sook] Chungnam Natl Univ, Coll Nursing, Daejeon, South Korea.
   [Kim, Mijung] Catholic Kkottongnae Univ, Dept Nursing, 133 Sangsam Gil, Cheongju 28211, South Korea.
   [Sohn, Eun Hee] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Coll Med, Dept Surg, Daejeon, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Res Inst Med Sci, Coll Med, Daejeon, South Korea.
C3 Chungnam National University; Chungnam National University; Chungnam
   National University Hospital; Chungnam National University; Chungnam
   National University
RP Kim, M (corresponding author), Catholic Kkottongnae Univ, Dept Nursing, 133 Sangsam Gil, Cheongju 28211, South Korea.
EM msj713@gmail.com; cipnmj@gmail.com; seh337@daum.net; leejin123@cnu.ac.kr
RI Lee-Bitar, Jin Sun/ISS-9717-2023
FU National Research Foundation of Korea [2017R1A2B4004328]
FX This work was supported by a grant from the National Research Foundation
   of Korea (2017R1A2B4004328).
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   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
   Han Q, 2020, J ADV NURS, V76, P1924, DOI 10.1111/jan.14375
   He W, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/786839
   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
   Hsieh CH, 2010, AM J CHINESE MED, V38, P675, DOI 10.1142/S0192415X10008147
   Hwang MS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019837
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   Jouya S., 2018, Evid Based Care J, V7, P55
   Jung MS, 2021, ANN PALLIAT MED, V10, P721, DOI 10.21037/apm-20-1469
   Kim SY, 2021, ASIAN ONCOL NURS, V21, P129, DOI 10.5388/aon.2021.21.3.129
   Li T, 2022, QUAL LIFE RES, V31, P3091, DOI 10.1007/s11136-022-03154-7
   Lin WC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/103570
   Mai QL, 2022, EUR J INTEGR MED, V51, DOI 10.1016/j.eujim.2022.102120
   mijung Kim, 2020, [The Journal of Fundamentals of Nursing, 기본간호학회지], V27, P323, DOI [10.7739/jkafn.2020.27.4.323, 10.7739/jkafn.2020.27.4.323]
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   Oleson T., 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Paice JA, 1997, CANCER NURS, V20, P88, DOI 10.1097/00002820-199704000-00002
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   Zheng SH, 2018, Frontiers of Nursing, V5, P227, DOI 10.1515/fon-2018-0030
   Zhong Baoliang, 2009, J Thorac Dis, V1, P51
NR 51
TC 4
Z9 6
U1 12
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD 2023 OCT 17
PY 2023
DI 10.1097/NCC.0000000000001286
EA OCT 2023
PG 12
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA GM8A2
UT WOS:001153166100002
PM 37851514
DA 2026-01-16
ER

PT J
AU Lam, WL
   Yeung, WF
   Wong, MK
   Cheung, CW
   Chan, KKL
   Ngan, HYS
   Wong, CKH
   Chen, HY
   Lao, LX
AF Lam, Wing Lok
   Yeung, Wing Fai
   Wong, Mei Kuen
   Cheung, Chi Wai
   Chan, Karen Kar Loen
   Ngan, Hextan Yuen Sheung
   Wong, Carlos King Ho
   Chen, Hai Yong
   Lao, Lixing
TI Combined electroacupuncture and auricular acupuncture for postoperative
   pain after abdominal surgery for gynecological diseases: study protocol
   for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE RCT; Health economic analysis; Placebo; Analgesia; Morphine consumption;
   AUC; Acupuncture; Operation
ID ORAL-SURGERY; RATING-SCALE; METAANALYSIS; RECOVERY
AB Background: Postoperative pain is a major complaint following abdominal surgery for gynecological diseases. Effective postoperative pain control after abdominal surgery is particularly important for patient recovery, mobility, and satisfaction. Acupuncture has been commonly used for pain management. However, its efficacy in postoperative pain control is inconclusive and health economic evaluation is limited.
   Methods: A randomized, sham-controlled, patient-and-assessor-blind trial is designed to evaluate the efficacy and safety of acupuncture in managing postoperative pain following abdominal surgery of gynecological diseases. Patients who are eligible for laparotomy with a midline incision for gynecological neoplasia, including ovarian mass, uterine mass, and cervical lesions, will be recruited. Seventy-two participants will be randomly allocated to an acupuncture or non-invasive sham control in a 1:1 ratio. Treatment will be done within 2 h before operation, upon arrival to the ward and once daily for 5 days. The Pain Numerical Rating Scale (NRS) on the first 5 days during hospitalization will be the primary outcome and will be analyzed using the area-under-the-curve (AUC) method. The secondary outcome measures include frequency of rescue analgesic use during hospital stay, cumulative morphine consumption; quality of recovery as measured by time to recovery variables and the Quality of Recovery-9 (QoR-9); quality of life as measured by the Short Form-6 dimension (SF-6D) and EuroQol-5 Dimension-5 Level (EQ-5D-5 L). The incremental cost-effectiveness ratio of acupuncture vs sham acupuncture will be calculated.
   Discussion: This study protocol provides an example of integrative medicine practice in a hospital setting for the management of postoperative pain using acupuncture treatment. The acupuncture treatment protocol, if proven to be effective, can be implemented in routine settings to play a role in postoperative pain management for patients who have undergone abdominal surgery for gynecological diseases.
C1 [Lam, Wing Lok; Wong, Mei Kuen; Chen, Hai Yong; Lao, Lixing] Univ Hong Kong, Sch Chinese Med, 10 Sassoon Rd, Pokfulam, Hong Kong, Peoples R China.
   [Yeung, Wing Fai] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Cheung, Chi Wai] Univ Hong Kong, Dept Anesthesiol, Queen Mary Hosp, 4-F K Block,102 Pokfulam Rd, Pokfulam, Hong Kong, Peoples R China.
   [Chan, Karen Kar Loen; Ngan, Hextan Yuen Sheung] Univ Hong Kong, Dept Obstet & Gynecol, Queen Mary Hosp, 6-F Professorial Block,102 Pokfulam Rd, Pokfulam, Hong Kong, Peoples R China.
   [Wong, Carlos King Ho] Univ Hong Kong, Dept Family Med & Primary Care, Ap Lei Chau Clin, 3-F,161 Main St, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong; Hong Kong Polytechnic University; University of
   Hong Kong; University of Hong Kong; University of Hong Kong
RP Lao, LX (corresponding author), Univ Hong Kong, Sch Chinese Med, 10 Sassoon Rd, Pokfulam, Hong Kong, Peoples R China.
EM lxlao1@hku.hk
RI CHEN, Haiyong/G-6787-2014; Lao, Lixing/P-9107-2019; Wong,
   Carlos/B-4322-2011; Yeung, Wing-Fai/E-7971-2013
OI CHEN, Haiyong/0000-0002-4889-2752; Lao, Lixing/0000-0003-0198-9714;
   Ngan, Hextan Y S/0000-0003-3945-159X
FU Health and Medical Research Fund (HMRF), Hong Kong [13142951]
FX This trial is funded by Health and Medical Research Fund (HMRF), Hong
   Kong (Ref no: 13142951). The funding body was not involved in the design
   of the study and collection, analysis, and interpretation of data, or in
   writing the manuscript.
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NR 46
TC 7
Z9 8
U1 1
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 4
PY 2018
VL 19
AR 8
DI 10.1186/s13063-017-2359-8
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FS2KK
UT WOS:000419607200007
PM 29301556
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Jung, MS
   Kim, M
   Sohn, EH
   Lee, JS
AF Jung, Mi Sook
   Kim, Mijung
   Sohn, Eun Hee
   Lee, Jin Sun
TI The Effectiveness and Safety of Nurse-Led Auricular Acupressure on
   Chemotherapy-Induced Peripheral Neuropathy Among Patients With Breast
   Cancer: A Randomized, Double-Blind, Sham-Controlled Trial
SO CANCER NURSING
LA English
DT Article
DE Auriculotherapy; Breast neoplasms; Drug toxicity; Peripheral nervous
   system disease
ID POINT ACUPRESSURE; OUTCOME MEASURES; PAIN; NEUROTOXICITY; ACUPUNCTURE;
   PREVALENCE; PREVENTION; MANAGEMENT; CONSENSUS; TOXICITY
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major symptom of distress among chemotherapy-treated cancer survivors. Although various interventions have been attempted, there is no criterion-standard treatment.
   Objective: The aim of this study was to examine the efficacy and safety of auricular acupressure (AA) in improving peripheral neuropathy symptoms in breast cancer patients undergoing taxane-based treatment.
   Methods: A total of 51 eligible participants were enrolled and randomly allocated (1:1) to AA or sham control groups. The intervention was performed weekly for 3 weeks using different ear points, depending on the group. The Total Neuropathy Score was used to measure CIPN objectively. The Numerical Rating Scale and the European Organization for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy-20 were used to measure the subjective symptoms of CIPN. Outcomes were compared between groups by time interaction using generalized estimating equations based on the intention-to-treat principle.
   Results: Only 1 participant dropped out because of nausea and mild fever. The results of generalized estimating equations showed significant improvement in Numerical Rating Scale scores on the hands and feet and total Chemotherapy-Induced Peripheral Neuropathy-20 in the experimental group compared with the sham control group (all Ps < .05). Although the experimental group showed a greater reduction in Total Neuropathy Score scores than the sham control group, no significant differences were found.
   Conclusion: Auricular acupressure is an effective and safe nurse-led intervention for managing CIPN symptoms in breast cancer patients.
   Implications for Practice: The findings help nurses to integrate AA easily and usefully into nursing care, contributing to managing symptoms of CIPN in cancer patients and survivors.
C1 [Jung, Mi Sook] Chungnam Natl Univ, Coll Nursing, Daejeon, South Korea.
   [Kim, Mijung] Catholic Kkottongnae Univ, Dept Nursing, 133 Sangsam Gil, Chungju 28211, South Korea.
   [Sohn, Eun Hee] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Coll Med, Dept Surg, Daejeon, South Korea.
   [Lee, Jin Sun] Chungnam Natl Univ, Coll Med, Res Inst Med Sci, Daejeon, South Korea.
C3 Chungnam National University; Chungnam National University; Chungnam
   National University Hospital; Chungnam National University; Chungnam
   National University
RP Jung, MS (corresponding author), Catholic Kkottongnae Univ, Dept Nursing, 133 Sangsam Gil, Chungju 28211, South Korea.
EM msj713@gmail.com; seh337@daum.net; leejin123@cnu.ac.kr
RI Lee-Bitar, Jin Sun/ISS-9717-2023
FU National Research Foundation of Korea [2017R1A2B4004328]
FX This work was supported by a grant from the National Research Foundation
   of Korea (2017R1A2B4004328). The funder had no role to play in the study
   design; in the collection, analysis, and interpretation of data; in the
   writing of the report; and in the decision to submit the article for
   publication.
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   Chien TJ, 2019, INTEGR CANCER THER, V18, DOI 10.1177/1534735419886662
   Cunningham JA, 2013, BMC MED RES METHODOL, V13, DOI 10.1186/1471-2288-13-150
   Di Maio M, 2015, J CLIN ONCOL, V33, P910, DOI 10.1200/JCO.2014.57.9334
   Greenlee H, 2016, BREAST CANCER RES TR, V156, P453, DOI 10.1007/s10549-016-3759-2
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   Hou PW, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/495684
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   Hwang MS, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019837
   Jordan B, 2020, ANN ONCOL, V31, P1306, DOI 10.1016/j.annonc.2020.07.003
   Jouya S., 2018, Evid Based Care J, V7, P55
   Jung MS, 2021, ANN PALLIAT MED, V10, P721, DOI 10.21037/apm-20-1469
   Kim SY, 2021, ASIAN ONCOL NURS, V21, P129, DOI 10.5388/aon.2021.21.3.129
   Li T, 2022, QUAL LIFE RES, V31, P3091, DOI 10.1007/s11136-022-03154-7
   Lin WC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/103570
   Mai QL, 2022, EUR J INTEGR MED, V51, DOI 10.1016/j.eujim.2022.102120
   mijung Kim, 2020, [The Journal of Fundamentals of Nursing, 기본간호학회지], V27, P323, DOI [10.7739/jkafn.2020.27.4.323, 10.7739/jkafn.2020.27.4.323]
   Oh PJ, 2018, J KOREAN ACAD NURS, V48, P123, DOI 10.4040/jkan.2018.48.2.123
   OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014
   Oleson T., 2014, Auriculotherapy Manual: Chinese and Western Systems of Ear Acupuncture
   Paice JA, 1997, CANCER NURS, V20, P88, DOI 10.1097/00002820-199704000-00002
   Postma TJ, 2005, EUR J CANCER, V41, P1135, DOI 10.1016/j.ejca.2005.02.012
   Romoli M, 2014, NEUROL SCI, V35, pS189, DOI 10.1007/s10072-014-1768-7
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
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   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/506758
   Tan JY, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/430796
   Visovsky Constance, 2007, Clin J Oncol Nurs, V11, P901
   White AR, 2001, COMPLEMENT THER MED, V9, P237, DOI 10.1054/ctim.2001.0489
   Williamson A, 2005, J CLIN NURS, V14, P798, DOI 10.1111/j.1365-2702.2005.01121.x
   Willson ML, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004421.pub3
   Winters-Stone KM, 2017, J CLIN ONCOL, V35, P2604, DOI 10.1200/JCO.2016.71.3552
   Yang YL, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1618767
   Yeh CH, 2019, PAIN MANAG NURS, V20, P614, DOI 10.1016/j.pmn.2019.04.005
   Yeh CH, 2016, CANCER NURS, V39, P402, DOI 10.1097/NCC.0000000000000303
   Yeh CH, 2015, PAIN MED, V16, P1857, DOI 10.1111/pme.12789
   Zhang CS, 2014, J ALTERN COMPLEM MED, V20, P147, DOI 10.1089/acm.2013.0238
   Zheng SH, 2018, Frontiers of Nursing, V5, P227, DOI 10.1515/fon-2018-0030
   Zhong Baoliang, 2009, J Thorac Dis, V1, P51
NR 51
TC 4
Z9 6
U1 12
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD MAR-APR
PY 2025
VL 48
IS 2
BP E64
EP E74
DI 10.1097/NCC.0000000000001286
EA OCT 2023
PG 11
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA 9ZY6Q
UT WOS:001619046600001
PM 37851514
DA 2026-01-16
ER

PT J
AU Arriaga-Pizano, L
   Gómez-Jiménez, DC
   Flores-Mejía, LA
   Pérez-Cervera, Y
   Solórzano-Mata, CJ
   Lopez-Macias, C
   Isibasi, A
   Torres-Rosas, R
AF Arriaga-Pizano, Lourdes
   Cuauhtemoc Gomez-Jimenez, Daniel
   Angel Flores-Mejia, Luis
   Perez-Cervera, Yobana
   Josue Solorzano-Mata, Carlos
   Lopez-Macias, Constantino
   Isibasi, Armando
   Torres-Rosas, Rafael
TI Low back pain in athletes can be controlled with acupuncture by a
   catecholaminergic pathway: clinical trial
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE acupuncture; low back pain; non-steroidal anti-inflammatory drugs; pain
   management; physical therapy; sports medicine
AB Background:
   Activation of the sympathetic nervous system attenuates inflammation via catecholamines. Recent evidence has shown that electroacupuncture (EA) activates neuronal networks involved in the release of dopamine and norepinephrine that control systemic inflammation. In muscle, catecholamines are related to cyclic adenosine monophosphate (cAMP). This signaling molecule has been implicated in recovery from sustained contractile activity, which may induce muscular pain, such as that which occurs during low back pain (LBP).
   Objective:
   Our aim was to evaluate the effects of EA used for the control of LBP on the activation of the sympathetic nervous system in a randomized controlled clinical trial in athletes.
   Methods:
   Two groups of athletes with acute or chronic low back pain were studied. EA, sham EA and pharmacological treatment (diclofenac sodium) were evaluated. The outcome measures included a pain score represented by a visual analogue scale (VAS) and serum levels of catecholamines quantified by enzyme-linked immunosorbent assay. In addition, blood was collected into chilled heparin tubes, placed in 96-well cell culture plates and incubated with an equal volume of Roswell Park Memorial Institute (RPMI) medium, with lipopolysaccharide (LPS) alone or with catecholamines. Tumor necrosis factor (TNF)-alpha levels in the supernatants were analyzed.
   Results:
   The results indicated that the initial pain ratings did not differ between the groups analyzed. EA induced epinephrine secretion but not norepinephrine or dopamine secretion. Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-alpha production in response to LPS stimuli.
   Conclusion:
   EA activates the sympathetic nervous system and induces the release of epinephrine, which could ameliorate inflammation and protect muscular tissue in addition to relieving pain.
C1 [Arriaga-Pizano, Lourdes; Angel Flores-Mejia, Luis; Lopez-Macias, Constantino; Isibasi, Armando] Hosp Especialidades Ctr Med Nacl Siglo XXI, Inst Mexicano Seguro Social IMSS, Unidad Invest Med Inmunoquim, Mexico City, DF, Mexico.
   [Cuauhtemoc Gomez-Jimenez, Daniel] Inst Politecn Nacl, Escuela Nacl Med & Homeopatia, Mexico City, DF, Mexico.
   [Perez-Cervera, Yobana; Josue Solorzano-Mata, Carlos; Torres-Rosas, Rafael] Univ Autonoma Benito Juarez Oaxaca, Fac Odontol, Ctr Estudios Ciencias Salud & Enfermedad, Lab Inmunol, Oaxaca, Oaxaca, Mexico.
   [Perez-Cervera, Yobana; Josue Solorzano-Mata, Carlos] Univ Autonoma Benito Juarez Oaxaca, Fac Med & Cirugia, Ctr Invest UNAM UABJO, Oaxaca, Oaxaca, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Politecnico Nacional -
   Mexico; Universidad Autonoma Benito Juarez de Oaxaca; Universidad
   Autonoma Benito Juarez de Oaxaca
RP Torres-Rosas, R (corresponding author), Univ Autonoma Benito Juarez Oaxaca, Div Posgrad, Fac Odontol, Ave Univ Sin Numero, Oaxaca 68120, Oaxaca, Mexico.
EM rtorres.cat@uabjo.mx
RI López Macías, Constatino III Roberto/NWZ-9162-2025; Arriaga-Pizano,
   Lourdes/AAI-9628-2021; Flores-Mejia, Luis/NOF-5573-2025; Perez-Cervera,
   Yobana/C-4700-2018; Solórzano-Mata, Carlos Josué/G-5260-2019; Gómez
   Jiménez, Daniel Cuauhtémoc/AGC-8906-2022; Torres Rosas,
   Rafael/G-6936-2019
OI López Macías, Constatino III Roberto/0000-0003-0530-492X;
   Solórzano-Mata, Carlos Josué/0000-0002-5735-0373; Gómez Jiménez, Daniel
   Cuauhtémoc/0000-0003-4844-4885; Torres Rosas, Rafael/0000-0002-5934-003X
FU CONACYT Basic Science [284495]; Strengthening Program in Educational
   Quality 2016 & 2017 (PFCE) Grant from Secretary of Public Education
   (SEP)
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by CONACYT Basic Science (grant no. 284495) and Strengthening
   Program in Educational Quality 2016 & 2017 (PFCE) Grant from Secretary
   of Public Education (SEP).
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NR 39
TC 8
Z9 16
U1 1
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD DEC
PY 2020
VL 38
IS 6
BP 388
EP 395
DI 10.1177/0964528420912251
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA PA8GG
UT WOS:000595867300003
PM 32429680
DA 2026-01-16
ER

PT J
AU Asmussen, S
   Przkora, R
   Maybauer, DM
   Fraser, JF
   Sanfilippo, F
   Jennings, K
   Adamzik, M
   Maybauer, MO
AF Asmussen, Sven
   Przkora, Rene
   Maybauer, Dirk M.
   Fraser, John F.
   Sanfilippo, Filippo
   Jennings, Kristofer
   Adamzik, Michael
   Maybauer, Marc O.
TI Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive
   Care
SO JOURNAL OF INTENSIVE CARE MEDICINE
LA English
DT Article
DE systematic review; transcutaneous electrical acupoint stimulation;
   anesthetic drugs; cytokines; immune response
ID ELECTRICAL-STIMULATION; AURICULAR ACUPUNCTURE; POSTOPERATIVE NAUSEA;
   ACUPOINT; RELEASE; SURGERY; RATS; CARDIOPROTECTION; PRETREATMENT;
   REPERFUSION
AB Background: Acupuncture treatment has been employed in China for over 2500 years and it is used worldwide as analgesia in acute and chronic pain. Acupuncture is also used in general anesthesia (GA). The aim of this systematic review and meta-analysis was to assess the efficacy of electroacupuncture (EA) in addition to GA in patients undergoing cardiac surgery. Methods: We searched 3 databases (Pubmed, Cochrane Library, and Web of Science-from 1965 until January 31, 2017) for randomized controlled trials (RCTs) including patients undergoing cardiac surgery and receiving GA alone or GA + EA. As primary outcomes, we investigated the association between GA + EA approach and the dosage of intraoperative anesthetic drugs administered, the duration of mechanical ventilation (MV), the postoperative dose of vasoactive drugs, the length of intensive care unit (ICU) and hospital stay, and the levels of troponin I and cytokines. Results: The initial search yielded 477 citations, but only 7 prospective RCTs enrolling a total of 321 patients were included. The use of GA + EA reduced the dosage of intraoperative anesthetic drugs (P < .05), leading to shorter MV time (P < .01) and ICU stay (P < .05) as well as reduced postoperative dose of vasoactive drugs (P < .001). In addition, significantly lower levels of troponin I (P < .01) and tumor necrosis factor alpha (P < .01) were observed. Conclusion: The complementary use of EA for open-heart surgery reduces the duration of MV and ICU stay, blunts the inflammatory response, and might have protective effects on the heart. Our findings stimulate future RCT to provide definitive recommendations.
C1 [Asmussen, Sven; Adamzik, Michael] Ruhr Univ Bochum, Univ Hosp Knappschaftskrankenhaus, Dept Anaesthesiol Intens Care & Pain Med, Schornau 23-25, D-44892 Bochum, Germany.
   [Asmussen, Sven; Przkora, Rene; Maybauer, Dirk M.; Jennings, Kristofer; Maybauer, Marc O.] Univ Texas Med Branch, Dept Anesthesiol, Galveston, TX 77555 USA.
   [Asmussen, Sven; Przkora, Rene; Maybauer, Dirk M.; Jennings, Kristofer; Maybauer, Marc O.] Univ Texas Med Branch, Dept Epidemiol & Biostat, Galveston, TX 77555 USA.
   [Asmussen, Sven; Fraser, John F.; Maybauer, Marc O.] Univ Queensland, Prince Charles Hosp, Crit Care Res Grp, Brisbane, Qld, Australia.
   [Przkora, Rene] Univ Florida, Coll Med, Dept Anesthesiol, Gainesville, FL USA.
   [Maybauer, Dirk M.; Maybauer, Marc O.] St George Hosp, Dept Cardiothorac Anaesthesia & Crit Care, London, England.
   [Sanfilippo, Filippo] ISMETT, IRCCS, Ist Mediterraneo Trapianti & Terapie Alta Special, Dept Anesthesia & Intens Care, Palermo, Italy.
   [Sanfilippo, Filippo] Philipps Univ, Dept Anaesthesiol & Intens Care, Marburg, Germany.
   [Maybauer, Marc O.] Univ Manchester, Manchester Royal Infirm, Cent Manchester Univ Hosp NHS Fdn Trust, Cardiothorac Anaesthesia & Intens Care, Manchester, Lancs, England.
C3 Ruhr University Bochum; University of Texas System; University of Texas
   Medical Branch Galveston; University of Texas System; University of
   Texas Medical Branch Galveston; Prince Charles Hospital; University of
   Queensland; State University System of Florida; University of Florida;
   City St Georges, University of London; IRCCS Istituto Mediterraneo per i
   Trapianti e Terapie ad Alta Specializzazione (ISMETT); Philipps
   University Marburg; University of Manchester
RP Asmussen, S (corresponding author), Ruhr Univ Bochum, Univ Hosp Knappschaftskrankenhaus, Dept Anaesthesiol Intens Care & Pain Med, Schornau 23-25, D-44892 Bochum, Germany.
EM sven.asmussen@kk-bochum.de
RI Sanfilippo, Filippo/N-7045-2017; Adamzik, Michael/HGE-9286-2022; Fraser,
   John F/ITV-8947-2023; Maybauer, Marc Oliver/I-2890-2012
OI Sanfilippo, Filippo/0000-0001-5144-0776; Jennings,
   Kristofer/0000-0002-5442-9326; Fraser, John F/0000-0002-7012-2519;
   Maybauer, Marc Oliver/0000-0003-2406-655X
FU Queensland Health OHMR; NHMRC [1010939]; National Health and Medical
   Research Council (NHMRC) [1010939] Funding Source: National Health and
   Medical Research Council (NHMRC)
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: JFF
   confirmed receipt of grant support from Queensland Health OHMR and NHMRC
   1010939.
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NR 48
TC 25
Z9 28
U1 1
U2 46
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0885-0666
EI 1525-1489
J9 J INTENSIVE CARE MED
JI J. Intensive Care Med.
PD AUG
PY 2019
VL 34
IS 8
BP 652
EP 661
DI 10.1177/0885066617708558
PG 10
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IF6JP
UT WOS:000473187300008
PM 28569130
DA 2026-01-16
ER

PT J
AU Wang, J
   Xia, Q
   Zhu, FY
   Huang, W
   Meng, YT
   Wang, YP
   Liu, YM
   Liu, XJ
   Li, HL
   Sun, B
AF Wang, Jing
   Xia, Qing
   Zhu, Fangyi
   Huang, Wei
   Meng, Yanting
   Wang, Yanping
   Liu, Yumei
   Liu, Xijun
   Li, Hulun
   Sun, Bo
TI Effects of Acupuncture on Adverse Events in Colonoscopy: A Systematic
   Review and Meta-analysis of Randomized Controlled Trials
SO PAIN AND THERAPY
LA English
DT Review
DE Acupuncture; Adverse events; Colonoscopy; Meta-analysis; Systematic
   review
ID ABDOMINAL-PAIN; ELECTROACUPUNCTURE; STIMULATION; QUALITY; COMPLICATIONS;
   ANALGESIA; SEDATION; CANCER; GRADE; TIME
AB Introduction Acupuncture has gradually penetrated into many disciplines in clinical medicine, such as surgery, anesthesia, and outpatient examinations. Although a number of clinical trials have investigated the effects of acupuncture on colonoscopy, the results were inconsistent. In this meta-analysis, we analyzed the effects of acupuncture on colonoscopy to provide evidence for subsequent research and clinical application of acupuncture in colonoscopy. Methods This meta-analysis was performed using Review Manager version 5.4 and Stata version 16 software. The primary outcome was the incidence of adverse events, and the secondary outcomes included patients' anxiety score before colonoscopy, time to insert the colonoscope, total detection time, propofol consumption, patients' pain score, and patient satisfaction rate. Results The results showed that the incidence of adverse events (odds ratio [OR] 0.27, 95% confidence interval [CI] 0.16-0.43, P = 0.00, I-2 = 25%), patients' pain score (mean difference [MD] - 1.03, 95% CI - 1.45 to - 0.62, P = 0.00, I-2 = 94%), and time to insert the colonoscope (MD = - 2.54, 95% CI - 4.96 to - 0.13, P = 0.04, I-2 = 0%) were significantly lower in the treatment group than in the control group. Compared with the control group, the satisfaction rate of patients (OR 2.53, 95% CI 1.56-4.10, P = 0.00, I-2 = 47%) in the treatment group was significantly improved. There was no significant between-group difference in patients' anxiety score, the total detection time, and propofol dosage. Conclusions During colonoscopy, acupuncture can significantly reduce the incidence of adverse events, relieve patients' pain, and improve patient satisfaction. Registration PROSPERO registration number CRD42022324428.
C1 [Wang, Jing; Zhu, Fangyi; Huang, Wei; Meng, Yanting; Wang, Yanping; Liu, Yumei; Liu, Xijun; Li, Hulun; Sun, Bo] Harbin Med Univ, Dept Neurobiol, Sch Basic Med Sci, 157 Hlth Rd, Harbin 150081, Heilongjiang, Peoples R China.
   [Xia, Qing] Harbin Med Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Harbin, Heilongjiang, Peoples R China.
   [Li, Hulun] Harbin Med Univ, Minist Educ, Key Lab Myocardial Ischemia, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Li, HL; Sun, B (corresponding author), Harbin Med Univ, Dept Neurobiol, Sch Basic Med Sci, 157 Hlth Rd, Harbin 150081, Heilongjiang, Peoples R China.
EM lihl@hrbmu.edu.cn; sunbo72022@163.com
RI sun, bo/JFA-9978-2023; wang, jing/HJA-5384-2022; Huang,
   Wei/OTG-5616-2025
FU National Natural Science Foundation of China [81771305, 81870955]; HMU
   Marshal Initiative Funding [HMUMIF21019]
FX This review paper is supported by the National Natural Science
   Foundation of China (Nos. 81771305 and 81870955) and the HMU Marshal
   Initiative Funding (HMUMIF21019). The journal's Rapid Service Fee was
   funded by these funds.
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NR 54
TC 8
Z9 8
U1 2
U2 14
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-8237
EI 2193-651X
J9 PAIN THER
JI PAIN THER.
PD DEC
PY 2022
VL 11
IS 4
BP 1095
EP 1112
DI 10.1007/s40122-022-00415-8
EA AUG 2022
PG 18
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5X6DI
UT WOS:000835636500001
PM 35922617
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lopez, AM
AF Lopez, Ana Maria
TI Integrative oncology in cancer care: Reaching a tipping point
SO CANCER
LA English
DT Editorial Material
DE acupuncture; anxiety; gyn oncology; integrative oncology; pain
ID ACUPUNCTURE
AB Preoperativerelaxation techniques decrease anxiety. The addition of intraoperative acupuncture reduced severe perioperative pain associated with gynecological oncology surgery.
C1 [Lopez, Ana Maria] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, 1025 Walnut St,Coll Bldg,Suite 700, Philadelphia, PA 19107 USA.
   [Lopez, Ana Maria] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, 1025 Walnut St,Coll Bldg,Suite 700, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University
RP Lopez, AM (corresponding author), Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, 1025 Walnut St,Coll Bldg,Suite 700, Philadelphia, PA 19107 USA.; Lopez, AM (corresponding author), Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, 1025 Walnut St,Coll Bldg,Suite 700, Philadelphia, PA 19107 USA.
EM anamaria.lopez@jefferson.edu
RI Lopez, Ana Maria/KII-1580-2024
OI Lopez, Ana Maria/0000-0002-2759-5353
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NR 15
TC 2
Z9 2
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD MAR 15
PY 2023
VL 129
IS 6
BP 834
EP 835
DI 10.1002/cncr.34539
EA JAN 2023
PG 2
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 9I9PV
UT WOS:000917999900001
PM 36647627
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Segev, Y
   Galil, G
   Marom, I
   Gressel, O
   Stein, N
   Hirsh, I
   Samuels, N
   Schmidt, M
   Schiff, E
   Lurie, I
   Lavie, O
AF Ben-Arye, Eran
   Segev, Yakir
   Galil, Galit
   Marom, Inbal
   Gressel, Orit
   Stein, Nili
   Hirsh, Irena
   Samuels, Noah
   Schmidt, Meirav
   Schiff, Elad
   Lurie, Irina
   Lavie, Ofer
TI Acupuncture during gynecological oncology surgery: A randomized
   controlled trial assessing the impact of integrative therapies on
   perioperative pain and anxiety
SO CANCER
LA English
DT Article
DE acupuncture; anxiety; gynecological oncology; integrative medicine;
   integrative oncology; pain; peri-operative
ID QUALITY-OF-LIFE; LOW-FREQUENCY ELECTROACUPUNCTURE; ELECTRICAL ACUPOINT
   STIMULATION; COMPLEMENTARY MEDICINE; POSTOPERATIVE PAIN;
   GENERAL-ANESTHESIA; RECOVERY SCORE; CANCER; PATIENT; NAUSEA
AB BackgroundIn this study, the impact of a multimodal integrative oncology pre- and intraoperative intervention on pain and anxiety among patients undergoing gynecological oncology surgery was explored. MethodsStudy participants were randomized to three groups: Group A received preoperative touch/relaxation techniques, followed by intraoperative acupuncture; Group B received preoperative touch/relaxation only; and a control group (Group C) received standard care. Pain and anxiety were scored before and after surgery using the Measure Yourself Concerns and Wellbeing (MYCAW) and Quality of Recovery (QOR-15) questionnaires, using Part B of the QOR to assess pain, anxiety, and other quality-of-life parameters. ResultsA total of 99 patients participated in the study: 45 in Group A, 25 in Group B, and 29 in Group C. The three groups had similar baseline demographic and surgery-related characteristics. Postoperative QOR-Part B scores were significantly higher in the treatment groups (A and B) when compared with controls (p = .005), including for severe pain (p = .011) and anxiety (p = .007). Between-group improvement for severe pain was observed in Group A compared with controls (p = .011). Within-group improvement for QOR depression subscales was observed in only the intervention groups (p <0.0001). Compared with Group B, Group A had better improvement of MYCAW-reported concerns (p = .025). ConclusionsA preoperative touch/relaxation intervention may significantly reduce postoperative anxiety, possibly depression, in patients undergoing gynecological oncology surgery. The addition of intraoperative acupuncture significantly reduced severe pain when compared with controls. Further research is needed to confirm these findings and better understand the impact of intraoperative acupuncture on postoperative pain. Plain language summary Integrative oncology programs are increasingly becoming part of supportive/palliative care, with many working within the Society for Integrative Oncology.This study examined the impact of a multimodal integrative oncology program on pain and anxiety among 99 patients undergoing gynecological oncology surgery. Participants were randomized to three groups: preoperative touch/relaxation treatments, followed by intraoperative acupuncture; preoperative touch/relaxation without acupuncture; and a control group receiving standard care only.The preoperative touch/relaxation intervention significantly reduced perioperative anxiety, with the addition of intraoperative acupuncture significantly reducing severe pain as well, when compared with controls. Further research is needed to confirm these findings.
C1 [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Lin Med Ctr, Integrat Oncol Program, Oncol Serv, Haifa, Israel.
   [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Zebulun Med Ctr, Oncol Serv, Integrat Oncol Program, Haifa, Israel.
   [Ben-Arye, Eran; Galil, Galit; Gressel, Orit] Clalit Hlth Serv, Carmel Med Ctr, Haifa, Israel.
   [Ben-Arye, Eran; Segev, Yakir; Gressel, Orit; Schiff, Elad; Lavie, Ofer] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Segev, Yakir; Marom, Inbal; Schmidt, Meirav; Lurie, Irina; Lavie, Ofer] Carmel Hosp, Dept Obstet & Gynecol, Haifa, Israel.
   [Stein, Nili] Carmel Hosp, Dept Community Med & Epidemiol, Haifa, Israel.
   [Hirsh, Irena] Carmel Hosp, Dept Anesthesiol Crit Care & Pain Med, Haifa, Israel.
   [Samuels, Noah] Hebrew Univ Jerusalem, Fac Med, Ctr Integrat Complementary Med, Shaarei Zedek Med Ctr, Jerusalem, Israel.
   [Schiff, Elad] Bnai Zion Hosp, Dept Internal Med & Integrat Med Serv, Haifa, Israel.
   [Ben-Arye, Eran] Lin Med Ctr, Oncol Serv, 35 Rothschild St, Haifa, Israel.
C3 Clalit Health Services; Clalit Health Services; Clalit Health Services;
   Carmel Medical Center; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; Clalit Health Services; Carmel Medical
   Center; Clalit Health Services; Carmel Medical Center; Clalit Health
   Services; Carmel Medical Center; Hebrew University of Jerusalem; Shaare
   Zedek Medical Center; Bnai Zion Medical Center
RP Ben-Arye, E (corresponding author), Lin Med Ctr, Oncol Serv, 35 Rothschild St, Haifa, Israel.
EM eranben@netvision.net.il
FU Israel Cancer Association [20180006]
FX ACKNOWLEDGMENT We thank Pesi Israeli, Michael Gretz, Walid Saliba, and
   Ludmila Ostrovsky for their contribution in development and
   implementation of the present research. This research was funded by the
   Israel Cancer Association (grant number 20180006). This study was not
   funded by any commercial source.
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NR 45
TC 18
Z9 26
U1 2
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD MAR 15
PY 2023
VL 129
IS 6
BP 908
EP 919
DI 10.1002/cncr.34542
EA JAN 2023
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 9I9PV
UT WOS:000913589500001
PM 36647622
DA 2026-01-16
ER

PT J
AU Kim, KH
   Kim, DH
   Kim, HY
   Son, GM
AF Kim, Kun Hyung
   Kim, Dae Hun
   Kim, Hee Young
   Son, Gyung Mo
TI Acupuncture for recovery after surgery in patients undergoing colorectal
   cancer resection: a systematic review and meta-analysis
SO ACUPUNCTURE IN MEDICINE
LA English
DT Review
ID ENHANCED RECOVERY; PERIOPERATIVE ACUPUNCTURE; POSTOPERATIVE ANALGESIA;
   ELECTROACUPUNCTURE; PAIN; STIMULATION; MOTILITY; CHALLENGES; OUTCOMES;
   IMPACT
AB Objective To assess the efficacy/effectiveness and safety of acupuncture in patients recovering from colorectal cancer resection.
   Methods We systematically searched four English language databases (Medline, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and AMED (Allied and Complementary Medicine Database)) and one Chinese database (CAJ, China Academic Journals). Randomised trials of acupuncture compared with usual/routine care, sham interventions or active comparators in patients undergoing colorectal cancer resection were eligible for inclusion. Postoperative symptoms and quality of life (QoL) were the primary outcomes for the review.
   Results Of 1225 screened hits, seven randomised trials with 540 participants were included. High or uncertain risk of bias and significant heterogeneity were observed. All outcomes were measured before discharge, and no trial explicitly reported post-discharge outcomes. The response to acupuncture in terms of postoperative symptoms was inconsistent across trials. QoL was not measured in the included studies. For certain outcomes reflecting physiological recovery, favourable effects of acupuncture were observed compared with sham acupuncture, namely time to first flatus (n=207, three studies; mean difference (MD) -7.48 h, 95% CI -14.58 to -0.39 h, I-2=0%) and time to first defaecation (n=149, two studies; MD -18.04 h, 95% CI -31.90 to -4.19 h, I-2=0%). Two studies reported there were no acupuncture-related adverse events, whereas the remaining studies did not consider adverse events.
   Conclusions We found low-to moderate-quality evidence for the efficacy and safety of acupuncture for recovery after surgery in colorectal cancer patients. Future trials with adequate allocation concealment, blinding of outcome assessors, and measurement of post-discharge outcomes including QoL or functional recovery are warranted.
C1 [Kim, Kun Hyung] Pusan Natl Univ, Sch Korean Med, Yangsan, South Korea.
   [Kim, Dae Hun] Pusan Natl Univ, Korean Med Hosp, Dept Acupuncture & Moxibust, Yangsan, South Korea.
   [Kim, Hee Young] Pusan Natl Univ, Yangsan Hosp, Dept Anesthesia & Pain Med, Yangsan, South Korea.
   [Son, Gyung Mo] Pusan Natl Univ, Yangsan Hosp, Dept Surg, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital
RP Son, GM (corresponding author), Pusan Natl Univ, Yangsan Hosp, Dept Surg, Yangsan 50612, South Korea.
EM skm171@empas.com
RI Kim, Hee Young/HII-5042-2022; Son, Gyung mo/W-2979-2019
OI Son, Gyung mo/0000-0002-8861-6293
FU National Research Foundation of Korean Government [2014R1A5A2009936];
   Korea Institute of Oriental Medicine [K16123]
FX This work was supported by a grant to the Korean Medical Science
   Research Center for Healthy Aging from the National Research Foundation
   of Korean Government (grant no. 2014R1A5A2009936) and the Korea
   Institute of Oriental Medicine (grant no. K16123). The funders had no
   role in the conduct of this study.
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NR 40
TC 35
Z9 39
U1 0
U2 33
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD AUG
PY 2016
VL 34
IS 4
BP 248
EP 256
DI 10.1136/acupmed-2015-010941
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DW9RE
UT WOS:000383998600002
PM 26921418
DA 2026-01-16
ER

PT J
AU Deng, G
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   Chan, Y
   Affuso, T
   Yeung, KS
   Coleton, M
   Sjoberg, D
   Vickers, A
   Cassileth, B
AF Deng, Gary
   Wong, W. Douglas
   Guillem, Jose
   Chan, Yi
   Affuso, Theresa
   Yeung, K. Simon
   Coleton, Marci
   Sjoberg, Daniel
   Vickers, Andrew
   Cassileth, Barrie
TI A Phase II, Randomized, Controlled Trial of Acupuncture for Reduction of
   Postcolectomy Ileus
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID MAJOR ABDOMINAL-SURGERY; MU-OPIOID ANTAGONIST; POSTOPERATIVE ILEUS;
   ALVIMOPAN; RECOVERY; ELECTROACUPUNCTURE; STIMULATION; EFFICACY
AB Postoperative ileus (POI) prolongs hospital stay and increases risk of postoperative complications. We conducted a randomized, sham-controlled trial to evaluate whether acupuncture reduces POI more effectively than sham acupuncture.
   Colon cancer patients undergoing elective colectomy were randomized to receive 30 min of true or sham acupuncture twice daily during their first 3 postoperative days. GI-3 (the later of the following two events: time that the patient first tolerated solid food, AND time that the patient first passed flatus OR a bowel movement) and GI-2 (the later of the following two events: time patient first tolerated solid food AND time patient first passed a bowel movement) were determined. Pain, nausea, vomiting, and use of pain medications were evaluated daily for the first 3 postoperative days.
   Ninety patients were randomized. Eighty-one received the allocated intervention: 39 in the true acupuncture group and 42 in the sham acupuncture group, all evaluated for the primary endpoint. The mean time to GI-3 was 149 h [standard deviation (SD) 71 h] and 146 (SD 62 h) after surgery for the acupuncture group and the sham acupuncture group (difference between means -2 h; 95 % confidence interval -31, 26; p = 0.9). No significant differences were found between groups for secondary endpoints.
   True acupuncture as provided in this study did not reduce POI more significantly than sham acupuncture. The study was limited by a standard deviation much larger than expected, suggesting that a study with a larger sample size might be required.
C1 [Deng, Gary; Chan, Yi; Affuso, Theresa; Yeung, K. Simon; Coleton, Marci; Cassileth, Barrie] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA.
   [Wong, W. Douglas; Guillem, Jose] Mem Sloan Kettering Canc Ctr, Colorectal Surg Serv, New York, NY 10021 USA.
   [Sjoberg, Daniel; Vickers, Andrew] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
C3 Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer
   Center; Memorial Sloan Kettering Cancer Center
RP Deng, G (corresponding author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1275 York Ave, New York, NY 10021 USA.
EM dengg@mskcc.org
RI Sjoberg, Daniel/B-8001-2011
OI Sjoberg, Daniel/0000-0003-0862-2018; Vickers, Anew/0000-0003-1525-6503;
   Yeung, Kwokwai/0000-0002-4930-4895
FU National Institutes of Health [R21CA122199]; National Cancer Institute
   [P30CA008748] Funding Source: NIH RePORTER
FX The authors thank Maria Kryza, Stacey Guillen, Derek Woo, James Lozada,
   Gria Jacobs, and Kristofer Prepelica for their assistance in the conduct
   of the study and the preparation of the manuscript. The study was
   supported by the National Institutes of Health grant number R21CA122199.
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NR 22
TC 32
Z9 37
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD APR
PY 2013
VL 20
IS 4
BP 1164
EP 1169
DI 10.1245/s10434-012-2759-7
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 109TV
UT WOS:000316392600018
PM 23188543
DA 2026-01-16
ER

PT J
AU Zhou, DF
   Rong, JC
   Zheng, SZ
   Zhang, K
   Yang, HZ
   Yang, LS
   Tang, CZ
AF Zhou, Dan-feng
   Rong, Jian-cheng
   Zheng, Shu-zhen
   Zhang, Kun
   Yang, Hong-zhi
   Yang, Lian-sheng
   Tang, Chun-zhi
TI Enhanced acupuncture therapy for radiotherapy-related neuropathic pain
   in patients with gynecologic cancer: a report of two cases and brief
   review
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE neuropathic pain; radiotherapy; acupuncture; cancer; case report
ID PREVALENCE; MANAGEMENT; OPIOIDS; DRUGS
AB As radiation therapy is increasingly utilized in the treatment of cancer, neuropathic pain (NP) is a common radiotherapy-related adverse effect and has a significant impact on clinical outcomes negatively. However, despite an improved understanding of neuropathic pain management, pain is often undertreated in patients with cancer. Herein, we reported two cases with radiotherapy-related neuropathic pain (RRNP) who presented a positive reaction to acupuncture. Patient 1 (a 73-year-old woman) with gynecologic cancer complained of burning and electric shock-like pain in the lower limb after radiotherapy. With the accepted combination of acupuncture and drugs, the pain was alleviated completely in 8 weeks. Patient 2 (a 64-year-old woman) accepted acupuncture in the absence of medication because of her inability to tolerate the adverse events of anticonvulsant drugs. She achieved remission of pain 4 weeks later. The results of this study showed that acupuncture might be promising for controlling the RRNP in patients with cancer, especially who were intolerant or unresponsive to medications.
C1 [Zhou, Dan-feng; Zheng, Shu-zhen; Zhang, Kun; Yang, Lian-sheng] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Acupuncture & Moxibust, Guangzhou, Peoples R China.
   [Rong, Jian-cheng] Jiangmen Cent Hosp, Dept Rehabil, Jiangmen, Peoples R China.
   [Yang, Hong-zhi] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Tradit Chinese Med, Guangzhou, Peoples R China.
   [Yang, Lian-sheng] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, Guangzhou, Peoples R China.
   [Tang, Chun-zhi] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Yang, LS (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Acupuncture & Moxibust, Guangzhou, Peoples R China.; Yang, LS (corresponding author), Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, Guangzhou, Peoples R China.; Tang, CZ (corresponding author), Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou, Peoples R China.
EM yanglsh5@mail.sysu.edu.cn; jordan664@gzucm.edu.cn
FU Construction Project of Inheritance Studio of National Famous and Old
   Traditional Chinese Medicine Experts in 2022
FX This study was funded by the Construction Project of Inheritance Studio
   of National Famous and Old Traditional Chinese Medicine Experts in 2022.
CR Ben-Arye E, 2022, CANCER-AM CANCER SOC, V128, P3641, DOI 10.1002/cncr.34422
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NR 26
TC 0
Z9 1
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD JUN 7
PY 2023
VL 14
AR 1163990
DI 10.3389/fneur.2023.1163990
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA J8UB9
UT WOS:001012310200001
PM 37351267
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Yang, P
   Wang, YC
   Xiao, YC
   Ma, QL
   Ma, RH
   Mi, J
   Hui, JR
AF Yang, Pu
   Wang, Yuanchun
   Xiao, Yingchun
   Ma, Qiaolin
   Ma, Runhong
   Mi, Jing
   Hui, Jianrong
TI Acupuncture for opioid-induced constipation Protocol for a systematic
   review and meta-analysis
SO MEDICINE
LA English
DT Review
DE acupuncture; opioid-induced constipation; meta-analysis; systematic
   review; protocol
ID MANAGEMENT; PATHOPHYSIOLOGY; DIAGNOSIS
AB Background: Opioid-induced constipation (OIC) is one of the most common complications of analgesic therapy for cancer pain patients who suffer moderate to severe pain. Acupuncture as an effective treatment in constipation has been widely applied. But its efficacy has not been assessed systematically. Thus, the purpose of this study is to provide a protocol to explore the efficacy and safety of acupuncture for OIC. Methods: Randomized Controlled Trials (RCTs) of acupuncture treatment for OIC in 4 Chinese electronic databases (China National Knowledge Infrastructure, Chinese Biological and Medical Database, China Scientific Journal Database, Wan-Fang Data) and 3 English electronic databases (PubMed, Embase, Cochrane Library) will be searched from their inception to September 31, 2020. RevMan 5.3 software and Stata 14.0 software will be used for meta-analysis, EndNote X9.2 and Cochrane Risk of Bias Tool will be used for literature screening and quality assessment. Results: This study will present an assessment of the efficacy and safety of acupuncture treatment for OIC patients through summarize high-quality clinical evidence. Conclusion: The conclusion of our systematic review and meta-analysis may provide evidence of whether acupuncture treatment is beneficial to patients with OIC. INPLASY registration number: INPLASY2020100026.
C1 [Yang, Pu; Xiao, Yingchun; Ma, Qiaolin; Ma, Runhong; Mi, Jing; Hui, Jianrong] Shaanxi Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Xian, Peoples R China.
   [Wang, Yuanchun] Shaanxi Univ Chinese Med, Affiliated Hosp, Xianyang, Shaanxi, Peoples R China.
C3 Shaanxi University of Chinese Medicine; Shaanxi University of Chinese
   Medicine
RP Hui, JR (corresponding author), Shaanxi Univ Chinese Med, Xixian New Area, 1 Shi Ji Ave, Xian, Shaanxi, Peoples R China.
EM jrjianrong99@163.com
OI Yang, Pu/0000-0002-6231-4721
FU Science and Technology Project of Shaanxi Provincial Administration of
   Traditional Chinese Medicine
FX This study is funded by the Science and Technology Project of Shaanxi
   Provincial Administration of Traditional Chinese Medicine
   (No.15-SCJH008).
CR Bandieri E, 2016, J CLIN ONCOL, V34, P436, DOI 10.1200/JCO.2015.61.0733
   Cai H, 2019, J INT MED RES, V47, P6337, DOI 10.1177/0300060519874539
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NR 23
TC 2
Z9 2
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 4
PY 2020
VL 99
IS 49
AR e23352
DI 10.1097/MD.0000000000023352
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6GR
UT WOS:000612838500051
PM 33285714
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Han, XY
   Wang, LJ
   Shi, HF
   Zheng, GF
   He, JS
   Wu, WJ
   Shi, JM
   Wei, GQ
   Zheng, WY
   Sun, J
   Huang, H
   Cai, Z
AF Han, Xiaoyan
   Wang, Lijuan
   Shi, Hongfei
   Zheng, Gaofeng
   He, Jingsong
   Wu, Wenjun
   Shi, Jimin
   Wei, Guoqing
   Zheng, Weiyan
   Sun, Jie
   Huang, He
   Cai, Zhen
TI Acupuncture combined with methylcobalamin for the treatment of
   chemotherapy-induced peripheral neuropathy in patients with multiple
   myeloma
SO BMC CANCER
LA English
DT Article
DE Acupuncture; CIPN; Methylcobalamin; Multiple myeloma
ID ELECTROACUPUNCTURE; PAIN; NEUROTOXICITY; BORTEZOMIB; HISTORY
AB Background: Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients.
   Methods: The MM patients (104 individuals) who met the inclusion criteria were randomly assigned into a solely methylcobalamin therapy group (500 mu g intramuscular methylcobalamin injections every other day for 20 days; ten injections) followed by 2 months of 500 mu g oral methylcobalamin administration, three times per day) and an acupuncture combined with methylcobalamin (Met + Acu) group (methylcobalamin used the same way as above accompanied by three cycles of acupuncture). Of the patients, 98 out of 104 completed the treatment and follow-ups. There were 49 patients in each group. The evaluating parameters included the visual analogue scale (VAS) pain score, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire scores, and electromyographic (EMG) nerve conduction velocity (NCV) determinations. We evaluated the changes of the parameters in each group before and after the therapies and made a comparison between the two groups.
   Results: After 84 days (three cycles) of therapy, the pain was significantly alleviated in both groups, with a significantly higher decrease in the acupuncture treated group (P < 0.01). The patients' daily activity evaluated by Fact/GOG-Ntx questionnaires significantly improved in the Met + Acu group (P < 0.001). The NCV in the Met + Acu group improved significantly while amelioration in the control group was not observed.
   Conclusions: The present study suggests that acupuncture combined with methylcobalamin in the treatment of CIPN showed a better outcome than methylcobalamin administration alone.
C1 [Han, Xiaoyan; Wang, Lijuan; Shi, Hongfei; Zheng, Gaofeng; He, Jingsong; Wu, Wenjun; Shi, Jimin; Wei, Guoqing; Zheng, Weiyan; Sun, Jie; Huang, He; Cai, Zhen] Zhejiang Univ, Sch Med, Dept Hematol,Affiliated Hosp 1, Multiple Myeloma Ctr,Bone Marrow Transplantat Ctr, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wang, Lijuan] Shandong Univ, Linyi Peoples Hosp, Hematol Lab, Dept Hematol, Linyi 276002, Peoples R China.
C3 Zhejiang University; Shandong University
RP Cai, Z (corresponding author), Zhejiang Univ, Sch Med, Dept Hematol,Affiliated Hosp 1, Multiple Myeloma Ctr,Bone Marrow Transplantat Ctr, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM caiz@zju.edu.cn
RI ; SUN, JIE/AAC-3145-2022
OI huang, he/0000-0002-2723-1621; 
FU Administration of Traditional Chinese Medicine Science and Technology
   Program of Zhejiang Province [2010ZA057, 2014ZB060]; Science and
   Technology Project of the Health Department of Zhejiang Province
   [2013KYA071]; National Natural Science Foundation of China [81471532,
   81402353]
FX The study was financially supported by grants from the Administration of
   Traditional Chinese Medicine Science and Technology Program of Zhejiang
   Province, Program Number: 2010ZA057, 2014ZB060; the Science and
   Technology Project of the Health Department of Zhejiang Province,
   Program Number: 2013KYA071; and the National Natural Science Foundation
   of China, Program Number: 81471532, 81402353.
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NR 36
TC 92
Z9 110
U1 1
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD JAN 9
PY 2017
VL 17
AR 40
DI 10.1186/s12885-016-3037-z
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EI2UD
UT WOS:000392343000001
PM 28068938
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhang, Y
   Li, A
   Xin, J
   Ren, K
   Berman, BM
   Lao, L
   Zhang, RX
AF Zhang, Y.
   Li, A.
   Xin, J.
   Ren, K.
   Berman, B. M.
   Lao, L.
   Zhang, R-X
TI Electroacupuncture alleviates chemotherapy-induced pain through
   inhibiting phosphorylation of spinal CaMKII in rats
SO EUROPEAN JOURNAL OF PAIN
LA English
DT Article
ID 5-HT1A RECEPTOR AGONIST; INDUCED PERIPHERAL NEUROPATHY; FOS PROTEIN
   EXPRESSION; KINASE-II; BRAIN-STEM; MECHANICAL ALLODYNIA; INFLAMMATORY
   PAIN; NOXIOUS STIMULUS; SEROTONIN 5-HT1A; PACLITAXEL
AB BackgroundCurrent medical treatments for chemotherapy-induced pain (CIP) are either ineffective or have adverse side effects. Acupuncture may alleviate CIP, but its effectiveness against this condition has not been studied. Paclitaxel causes neuropathic pain in cancer patients.
   MethodsWe evaluated the effects of electroacupuncture (EA) on paclitaxel-induced CIP in a rat model. Paclitaxel (2mg/kg) or vehicle was injected (i.p.) on alternate days of 0-6. The resulting pain was treated with 10Hz/2mA/0.4ms pulse EA for 30min at the equivalent of human acupoint GB30 (Huantiao) once every other day between days 14 and 26. For sham control, EA needles were inserted into GB30 without stimulation. Von Frey filaments with bending forces of 2-8g and 15g were used to assess mechanical allodynia and hyperalgesia, respectively, on day 13 and once every other day between 14-26days and then for 2-3weeks after EA treatment.
   ResultsCompared to sham control, EA significantly alleviated paclitaxel-induced mechanical allodynia and hyperalgesia, as shown by less frequent withdrawal responses to the filaments. The alleviation of allodynia/hyperalgesia lasted up to 3weeks after the EA treatment. EA significantly inhibited phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the spinal cord. KN-93, a selective inhibitor of p-CaMKII, inhibited mechanical allodynia/hyperalgesia and p-CaMKII. 5-HT1A receptor antagonist blocked EA inhibition of allodynia/hyperalgesia and p-CaMKII.
   ConclusionsElectroacupuncture activates 5-HT 1A receptors in the spinal cord and inhibits p-CaMKII to alleviate both allodynia and hyperalgesia. The data support acupuncture/EA as a complementary therapy for CIP.
   SignificanceElectroacupuncture (EA) activates spinal 5-HT1A receptors to inhibit p-CaMKII to alleviate paclitaxel-induced pain. Acupuncture/EA may be used as a complementary therapy for CIP.
C1 [Zhang, Y.] Shanxi Med Univ, Dept Physiol, Taiyuan, Shanxi, Peoples R China.
   [Li, A.; Xin, J.; Berman, B. M.; Lao, L.; Zhang, R-X] Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA.
   [Ren, K.] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA.
C3 Shanxi Medical University; University System of Maryland; University of
   Maryland Baltimore; University System of Maryland; University of
   Maryland Baltimore
RP Zhang, RX (corresponding author), Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA.
EM Rzhang@som.umaryland.edu
RI Lao, Lixing/P-9107-2019
OI Lao, Lixing/0000-0003-0198-9714
FU NIH [R21 AT004113, R21 AT008467-01A1]
FX NIH grants R21 AT004113 and R21 AT008467-01A1.
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NR 61
TC 31
Z9 39
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1090-3801
EI 1532-2149
J9 EUR J PAIN
JI Eur. J. Pain
PD APR
PY 2018
VL 22
IS 4
BP 679
EP 690
DI 10.1002/ejp.1132
PG 12
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA FZ4LO
UT WOS:000427563900005
PM 29034548
DA 2026-01-16
ER

PT J
AU Ben-Arye, E
   Gamus, D
   Samuels, N
   Schiff, E
   Hausner, D
   Gressel, O
   Attias, S
   Lavie, O
   David, A
   Shulman, K
   Agbarya, A
AF Ben-Arye, Eran
   Gamus, Dorit
   Samuels, Noah
   Schiff, Elad
   Hausner, David
   Gressel, Orit
   Attias, Samuel
   Lavie, Ofer
   David, Adi
   Shulman, Katerina
   Agbarya, Abed
TI Acupuncture and integrative oncology for taxane-induced peripheral
   neuropathy: a randomized multicentered study
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Quality of Life (PRO); Palliative Care
ID BREAST-CANCER PATIENTS; CHEMOTHERAPY; ELECTROACUPUNCTURE; PACLITAXEL;
   THERAPY; SAFETY; TRIAL; PREVENTION; EFFICACY; WOMEN
AB Objective To compare the effectiveness of acupuncture alone or with additional integrative oncology modalities for taxane-induced peripheral neuropathy-related symptoms in patients with gynecological and breast cancer.Methods The study was a prospective evaluation of patients undergoing twice-weekly treatments with either acupuncture alone (single-modality, group A) or with additional manual-movement and mind- body therapies (multimodality, group B), for 6 weeks. Symptom severity was assessed at baseline, 6 weeks, and 9 weeks using the Functional Assessment of Cancer Therapy-Taxane (FACT-Tax) tool; and von Frey perception thresholds. Additional symptoms were also assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ- C30) and the Measure Yourself Concerns and Wellbeing (MYCaW) study tool.Results For the 120 participants (60 in each study arm), baseline to 6- week scores were similar in both groups for improved FACT- Tax physical wellbeing and scores for hand numbness/tingling; EORTC physical functioning and global health status; and MYCaW scores. FACT- Tax taxane subscales and scores for foot numbness/tingling improved only in group A (p=0.038), while emotional wellbeing FACT-Tax (p=0.02) and EORTC pain (p=0.005) improved only in group B. Group B showed greater improvement for FACT-Tax neuropathy-related concerns than group A at 24 hours (p=0.043) and 7 days (p=0.009) after the first treatment.Conclusion Acupuncture alone or with additional integrative oncology modalities may help reduce neuropathy-related symptoms. The single-modality group demonstrated greater improvement for foot numbness/ tingling, and the multimodality group demonstrated improvement for pain and improved emotional wellbeing and neuropathy-related concerns in the first week of treatment.
C1 [Ben-Arye, Eran; Gressel, Orit] Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Haifa, Israel.
   [Ben-Arye, Eran; Schiff, Elad; Lavie, Ofer] Technion Israel Inst Technol, Haifa, Israel.
   [Gamus, Dorit; Hausner, David; David, Adi] Sheba Med Ctr, Tel Hashomer, Israel.
   [Samuels, Noah] Shaare Zedek Med Ctr, Jerusalem, Israel.
   [Schiff, Elad] Dept Internal Med, Haifa, Israel.
   [Schiff, Elad; Attias, Samuel; Agbarya, Abed] Bnai Zion Med Ctr, Haifa, Israel.
   [Lavie, Ofer] Lady Davies Carmel Med Ctr, Haifa, Israel.
   [Shulman, Katerina] LIN Med Ctr, Haifa, Israel.
C3 Clalit Health Services; Technion Israel Institute of Technology; Tel
   Aviv University; Chaim Sheba Medical Center; Hebrew University of
   Jerusalem; Shaare Zedek Medical Center; Bnai Zion Medical Center; Clalit
   Health Services; Carmel Medical Center
RP Ben-Arye, E (corresponding author), Clalit Hlth Serv, Lin Med Ctr, Oncol Serv, Haifa, Israel.
EM eranben@netvision.net.il
RI hausner, david/AAW-9363-2020; David, Adi/LBI-5899-2024; Agbarya,
   Abed/JGZ-5006-2023
OI hausner, david/0009-0008-8623-0347; David, Adi/0009-0008-0617-9933;
   Agbarya, Abed/0000-0002-3330-2959
FU Adelis Foundation
FX This Research was funded by the Adelis Foundation. This study was not
   funded by any commercial source.
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NR 42
TC 4
Z9 6
U1 2
U2 23
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1048-891X
EI 1525-1438
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD MAY
PY 2023
VL 33
IS 5
BP 792
EP 801
DI 10.1136/ijgc-2022-004004
EA DEC 2022
PG 10
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA AU2W9
UT WOS:000903154300001
PM 36600535
DA 2026-01-16
ER

PT J
AU Lan, XC
   Li, J
   Zhou, GS
   Wei, W
AF Lan, Xiaochun
   Li, Jun
   Zhou, Guisheng
   Wei, Wei
TI Study on the mechanism of acupuncture combined with massage therapy in
   improving waist flexion range and relieving pain in patients with
   chronic lumbago and leg pain
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Chronic lumbago and leg pain; acupuncture; massage reduction;
   combination therapy; waist flexion; pain
ID LOW-BACK-PAIN; MANAGEMENT; MOBILIZATION
AB This study aimed to explore the mechanism of acupuncture combined with massage reduction in improving waist flexion range and relieving pain in patients with chronic lumbago and leg pain. In total, 93 patients with chronic lumbago and leg pain in our hospital were divided into two groups according to the treatment methods. Group A received conventional drug therapy and group B received acupuncture combined with massage reduction in addition to treatment of group A. The efficacy, waist flexion range, modified Japanese Orthopaedic Association (M-JOA) score rating system for low back disorders, modified Oswestry disability index (ODI), visual analog scale (VAS), and inflammatory factors were compared before and after treatment. After treatment, the lumbar curvature, waist flexion range, M-JOA, ODI, VAS scores, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in group B were superior to group A (P < 0.05). Acupuncture combined with massage reduction in patients with chronic lumbago and leg pain is beneficial to further improve the clinical efficacy.
C1 [Lan, Xiaochun; Li, Jun; Zhou, Guisheng] Guangxi Med Univ, Dept Rehabil Med, Wuming Hosp, Nanning 530199, Guangxi, Peoples R China.
   [Wei, Wei] Guangxi Med Univ, Dept Orthopaed, Wuming Hosp, 26 Yongning Rd, Nanning 530199, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University
RP Wei, W (corresponding author), Guangxi Med Univ, Dept Orthopaed, Wuming Hosp, 26 Yongning Rd, Nanning 530199, Guangxi, Peoples R China.
EM pjcnkj@163.com
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NR 28
TC 0
Z9 0
U1 0
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 6
BP 4166
EP 4172
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MG5HE
UT WOS:000546062300048
DA 2026-01-16
ER

PT J
AU Shen, QY
   Deng, DH
   Li, GL
   Ruan, JY
   Shao, XY
   Wang, PP
   Li, XY
   Li, RR
   Bao, WL
   Chen, WJ
   Lu, C
AF Shen, Qiongying
   Deng, Dehou
   Li, Guangliang
   Ruan, Jiayin
   Shao, Xiying
   Wang, Peipei
   Li, Xiaoyu
   Li, Rongrong
   Bao, Wenlong
   Chen, Weiji
   Lu, Chao
TI Electroacupuncture frequency for chemotherapy-induced neuropathy in
   breast cancer: a randomized controlled trial
SO ONCOLOGIST
LA English
DT Article
DE electroacupuncture; breast cancer; chemotherapy-induced peripheral
   neuropathy
ID QUALITY-OF-LIFE; INDUCED PERIPHERAL NEUROPATHY; ACUPUNCTURE; PAIN;
   QUESTIONNAIRE; THERAPY; RATS
AB Background Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent dose-limiting toxicity in breast cancer patients. Electroacupuncture (EA) shows promise but optimal stimulation parameters remain undefined. We conducted a randomized trial comparing EA frequencies for CIPN.Methods This single-center, single-blind trial randomized patients to 2, 100, and 2/100 Hz EA, or mecobalamin (Mecbl). The primary outcome was the patient neurotoxicity questionnaire (PNQ) response rate at Week 4. Secondary outcomes included PNQ scores, National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) grades at Weeks 4/8, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 (EORTC QLQ-CIPN20) and Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) scales.Results 2/100 Hz EA achieved the highest overall response rate. Both 2 and 2/100 Hz EA improved PNQ sensory scores at Week 4. Sensory scores improved across groups, while motor scores decreased with 2 and 2/100 Hz EA. Only 2 Hz EA improved autonomic function. For quality-of-life, 2 Hz EA enhanced physical function, fatigue, pain and insomnia, while 2/100 Hz EA improved nausea/vomiting, constipation, appetite and global health with additional pain relief at Week 4. The 100 Hz EA group showed no significant benefits in these domains.Conclusions This study preliminarily explored EA's potential benefits for CIPN, with 2/100 Hz showing the highest response rate and 2 Hz demonstrating sensory improvement advantages. Different frequencies produced distinct therapeutic profiles. Further research should evaluate frequency-specific effects of EA for CIPN.
C1 [Shen, Qiongying; Li, Xiaoyu] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou 310053, Peoples R China.
   [Deng, Dehou; Wang, Peipei; Bao, Wenlong; Lu, Chao] Zhejiang Canc Hosp, Dept Tradit Chinese Med, 1 East Banshan Rd, Hangzhou 310022, Peoples R China.
   [Li, Guangliang; Shao, Xiying] Zhejiang Canc Hosp, Dept Breast Med Oncol, Hangzhou 310022, Peoples R China.
   [Ruan, Jiayin] Hong Kong Polytech Univ, Sch Nursing, Hong Kong 999077, Peoples R China.
   [Li, Rongrong; Chen, Weiji] Chinese Med Univ, Affiliated Hosp Zhejiang 3, Zhongshan Hosp Zhejiang Prov, Dept Acupuncture & Moxibust, Hangzhou 310009, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Cancer Hospital; Zhejiang
   Cancer Hospital; Hong Kong Polytechnic University; China Medical
   University
RP Lu, C (corresponding author), Zhejiang Canc Hosp, Dept Tradit Chinese Med, 1 East Banshan Rd, Hangzhou 310022, Peoples R China.
EM luchao@zjcc.org.cn
RI Wang, Peipei/LYN-9808-2024; Li, Guangliang/B-6715-2011; shen,
   qiongying/KVB-9873-2024; Ruan, Jia Yin/PFR-1511-2026; Li,
   Rongrong/B-8365-2019; Lu, Chao/ODK-2866-2025
OI Lu, Chao/0000-0002-0762-5797
FU Zhejiang Traditional Chinese Medicine Administration [2022ZB058]
FX The work was supported by the Zhejiang Traditional Chinese Medicine
   Administration (No. 2022ZB058).
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NR 39
TC 0
Z9 0
U1 5
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1083-7159
EI 1549-490X
J9 ONCOLOGIST
JI Oncologist
PD SEP
PY 2025
VL 30
IS 9
AR oyaf262
DI 10.1093/oncolo/oyaf262
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 7MV5B
UT WOS:001574767000001
PM 40828899
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Lee, I
   Garland, SN
   DeMichele, A
   Farrar, JT
   Im, EO
   Mao, JJ
AF Lee, Iris
   Garland, Sheila N.
   DeMichele, Angela
   Farrar, John T.
   Im, Eun-Ok
   Mao, Jun J.
TI A cross-sectional survey of pain catastrophising and acupuncture use
   among breast cancer survivors
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
ID INHIBITOR-INDUCED ARTHRALGIA; MUSCULOSKELETAL PAIN; FEAR-AVOIDANCE;
   TRIAL; ARTHRITIS; SCALE; DEPRESSION; SYMPTOMS; ANXIETY; WOMEN
AB Introduction Treatment-related joint pain affects almost half of all women with breast cancer using aromatase inhibitors and is a major reason for terminating treatment. Although acupuncture is becoming an increasingly popular, evidence-based option for treating pain, little is known about the potential influence of psychological factors on acupuncture use.
   Objective We aimed to evaluate the association between pain catastrophising and use of acupuncture in breast cancer survivors experiencing arthralgia.
   Methods We conducted a cross-sectional survey of arthralgic breast cancer patients. Patients were asked if they had used acupuncture since their cancer diagnosis. The Pain Catastrophising Scale (PCS) was used to measure negative coping styles related to the experience of pain. We performed multiple logistic regression analysis to evaluate the relationship between pain catastrophising and acupuncture use, adjusting for covariates.
   Results Of the 424 participants, 69 (16%) reported use of acupuncture since their breast cancer diagnosis. In multivariate analyses, compared to those in the lowest PCS score tertile, patients with the highest PCS scores were more likely to have used acupuncture (p=0.03). In particular, patients with high levels of rumination (p=0.005) and magnification (p=0.008) were more likely to have used acupuncture. Helplessness was not associated with acupuncture use (p=0.23).
   Conclusions High levels of pain catastrophising, and specifically the processes of rumination and magnification, were associated with greater acupuncture use. We believe this could have important implications for understanding which population is more likely to seek acupuncture treatment and how this alternative therapy could be better targeted to these patients.
C1 [Lee, Iris; Garland, Sheila N.; Mao, Jun J.] Univ Pennsylvania, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.
   [Lee, Iris; DeMichele, Angela; Farrar, John T.; Mao, Jun J.] Univ Pennsylvania, Perelman Sch Med, Dept Biostatist & Epidemiol, Philadelphia, PA 19104 USA.
   [Garland, Sheila N.] Mem Univ Newfoundland, Dept Psychol, St John, NF, Canada.
   [DeMichele, Angela; Farrar, John T.; Im, Eun-Ok; Mao, Jun J.] Univ Pennsylvania, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA USA.
   [Im, Eun-Ok] Univ Pennsylvania, Sch Nursing, Philadelphia, PA USA.
   [Mao, Jun J.] Mem Sloan Kettering Canc Ctr, Bendheim Ctr Integrat Med, 1429 First Ave, New York, NY 10021 USA.
C3 University of Pennsylvania; University of Pennsylvania; Memorial
   University Newfoundland; University of Pennsylvania; University of
   Pennsylvania; Memorial Sloan Kettering Cancer Center
RP Mao, JJ (corresponding author), Univ Pennsylvania, Perelman Sch Med, Dept Family Med & Community Hlth, Philadelphia, PA 19104 USA.; Mao, JJ (corresponding author), Univ Pennsylvania, Perelman Sch Med, Dept Biostatist & Epidemiol, Philadelphia, PA 19104 USA.; Mao, JJ (corresponding author), Univ Pennsylvania, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA USA.; Mao, JJ (corresponding author), Mem Sloan Kettering Canc Ctr, Bendheim Ctr Integrat Med, 1429 First Ave, New York, NY 10021 USA.
EM maoj@mskcc.org
RI Farrar, John/AAP-4788-2021; Garland, Sheila/AGL-7759-2022
OI Garland, Sheila/0000-0002-6119-318X
FU National Center for Complementary and Alternative Medicine [K23
   AT004112]; National Cancer Institute [R01 CA158243]; National Institutes
   of Health/National Cancer Institute Cancer Center [P30 CA008748]
FX JJM is funded in part by grants from the National Center for
   Complementary and Alternative Medicine (K23 AT004112), the National
   Cancer Institute (R01 CA158243), and the National Institutes of
   Health/National Cancer Institute Cancer Center (P30 CA008748).
CR [Anonymous], 2015, BRIEF PAIN INV
   Asmundson G.J. G., 2004, Understanding and treating fear of pain, P3
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NR 35
TC 6
Z9 7
U1 0
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-5284
EI 1759-9873
J9 ACUPUNCT MED
JI Acupunct. Med.
PD FEB
PY 2017
VL 35
IS 1
AR 38
DI 10.1136/acupmed-2016-011056
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA EP3BQ
UT WOS:000397257900006
PM 27177930
DA 2026-01-16
ER

PT J
AU Lagerstedt, K
   Efverman, A
AF Lagerstedt, Kristina
   Efverman, Anna
TI A Randomized Sham-Controlled Mixed Methods Pilot Study of the
   Feasibility of Acupuncture for Chemotherapy-Induced Neuropathy: Lessons
   Learned From Patient Experiences in Integrative Cancer Care
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE acupuncture; pain; neurotoxicity; neuropathy; complementary and
   alternative therapies; integrative oncology; nursing; physiotherapy;
   cancer rehabilitation
ID INDUCED PERIPHERAL NEUROPATHY; QUALITY-OF-LIFE; OXALIPLATIN; PAIN;
   NEUROTOXICITY; DISABILITY; COHORT; WOMEN
AB ObjectiveSince there is a lack of effective pharmacological therapies for chemotherapy-induced neuropathy and many patients ask for integrative cancer therapies such as acupuncture, the objective of this pilot study was to describe patients' experiences, and to study the feasibility and short-term effects of genuine acupuncture for chemotherapy-induced neuropathic pain and unpleasant sensations compared to sham acupuncture. Methods:The pilot study used mixed methods, collecting quantitative and qualitative data. Patients (n = 12) with chemotherapy-induced neuropathy after colorectal cancer were blindly randomized to genuine acupuncture or telescopic sham acupuncture. Individual interviews were conducted, and were analyzed using qualitative content analysis. The patients registered pain and unpleasant sensations (100 mm Visual Analog Scales) before and after n = 120 sessions, n = 60 genuine and n = 60 sham acupuncture sessions. Results:Five categories of patient experiences were described. The neuropathy negatively affected life. Physical activity was perceived to be important for health, but neuropathy was a barrier. The neuropathy required symptom-managing strategies. Acupuncture was pleasant and valuable, but some patients presented doubts regarding its effect mechanisms. After the genuine acupuncture sessions, pain (mean -2.0 steps relief during each session) and unpleasant sensations (-2.4) in the face was reduced more than after sham acupuncture (+0.1 steps worse pain, P = .018, +0.1 steps worse unpleasant sensations, P = .036). After genuine acupuncture, unpleasant sensations in the hands were reduced less (-0.23) compared to after sham acupuncture (-5.5, P = .002). Pain or unpleasant sensations in the feet did not change. Conclusions:Patients experienced that the neuropathy negatively changed their life and that acupuncture was pleasant and valuable. Patients receiving genuine acupuncture had short-term effects regarding pain and unpleasant sensations in the face compared to patients receiving sham acupuncture, while hands and feet did not improve. The patients were successfully blinded and complied with the acupuncture. We welcome future full-scaled randomized sham-controlled acupuncture studies.
C1 [Lagerstedt, Kristina] Reg Kronoberg, Vaxjo, Sweden.
   [Efverman, Anna] Univ Gavle, Gavle, Sweden.
   [Efverman, Anna] Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
C3 University of Gavle; University of Gavle
RP Efverman, A (corresponding author), Univ Gavle, Fac Hlth & Occupat Studies, Dept Caring Sci, S-80176 Gavle, Sweden.
EM anna.efverman@hig.se
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NR 48
TC 9
Z9 9
U1 7
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD JUN
PY 2023
VL 22
AR 15347354231178877
DI 10.1177/15347354231178877
PG 14
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA I6IK0
UT WOS:001003798900001
PM 37294052
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, MY
   Kwok, SWH
   Tan, JY
   Bressington, D
   Liu, XL
   Wang, T
   Chen, SL
AF Li, Meng -Yuan
   Kwok, Stephen Wai Hang
   Tan, Jing-Yu (Benjamin)
   Bressington, Daniel
   Liu, Xian-Liang
   Wang, Tao
   Chen, Shun-Li
TI Somatic acupressure for the fatigue-sleep disturbance-depression symptom
   cluster in breast cancer survivors: A phase II randomized controlled
   trial
SO EUROPEAN JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE Breast neoplasms; Acupressure; Fatigue; Sleep disorder; Depression;
   Symptom cluster; Randomized controlled trial
ID QUALITY-OF-LIFE; CHINESE VERSION; SAMPLE-SIZE; ACUPUNCTURE; RELIABILITY;
   VALIDATION; PROGRAM; MANAGE; WOMEN; PAIN
AB Objective: To evaluate the feasibility of the somatic acupressure (SA) for managing the fatigue-sleep disturbance-depression symptom cluster (FSDSC) among breast cancer (BC) survivors and its preliminary effects.Methods: In this Phase II randomized controlled trial (RCT), 51 participants were randomised evenly into the true SA group, sham SA group, and usual care group. All the participants received usual care. The two SA groups performed additional true or sham self-acupressure daily for seven weeks. The primary outcomes related to the assessment of participants' recruitment and compliance with study questionnaires and interventions. Clinical outcomes assessed the preliminary effects of SA on fatigue, sleep disturbance, depression, and quality of life. Semi-structured interviews were undertaken to capture participants' experiences of participating in this study. The statistical effects of the intervention on the outcomes were modelled in repeated measures ANOVA and adjusted generalized estimating equations.Results: Forty-five participants completed the SA intervention. No adverse events were reported. Over 85% of the participants could sustain for 25 days or more and 15 min or more per session, but the adherence to the intervention requirement was yet to improve. The group by time effect of the FSDSC and depression were significant (p < 0.05). Qualitative findings showed that participants positively viewed SA as a beneficial strategy for symptom management. Conclusions: The SA intervention protocol and the trial procedures were feasible. The results demonstrated signs of improvements in targeted outcomes, and a full-scale RCT is warranted to validate the effects of SA on the FSDSC.
C1 [Li, Meng -Yuan; Liu, Xian-Liang; Wang, Tao] Charles Darwin Univ, Fac Hlth, Brisbane Ctr, Sch Nursing, Brisbane, Qld, Australia.
   [Kwok, Stephen Wai Hang] Murdoch Univ, Harry Butler Inst, Perth, WA, Australia.
   [Kwok, Stephen Wai Hang; Tan, Jing-Yu (Benjamin); Bressington, Daniel] Charles Darwin Univ, Fac Hlth, Sch Nursing, Ellengowan Dr, Casuarina, NT, Australia.
   [Chen, Shun-Li] Southwest Med Univ, Affiliated Hosp, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China.
   [Wang, Tao] Charles Darwin Univ, Fac Hlth, Brisbane Ctr, Sch Nursing, 410 Ann St, Brisbane, Qld, Australia.
   [Chen, Shun-Li] Southwest Med Univ, Affiliated Hosp, Luzhou 25 Taiping St, Jiangyang Dist Luzhou, Sichuan, Peoples R China.
C3 Charles Darwin University; Murdoch University; Charles Darwin
   University; Southwest Medical University; Charles Darwin University;
   Southwest Medical University
RP Wang, T (corresponding author), Charles Darwin Univ, Fac Hlth, Brisbane Ctr, Sch Nursing, 410 Ann St, Brisbane, Qld, Australia.; Chen, SL (corresponding author), Southwest Med Univ, Affiliated Hosp, Luzhou 25 Taiping St, Jiangyang Dist Luzhou, Sichuan, Peoples R China.
EM mengyuanli@students.cdu.edu.au; stephen.kwok@murdoch.edu.au;
   benjamin.tan@cdu.edu.au; daniel.bressington@cdu.edu.au;
   daniel.liu@cdu.edu.au; alison.wang@cdu.edu.au; chen1054633477@163.com
RI ; TAN, JINGYU/AAE-5262-2022; Bressington, Daniel/G-2789-2017; Liu,
   Xian-Liang/JCE-5149-2023; WANG, Tao/B-9919-2014
OI Li, Mengyuan/0009-0003-9476-2734; TAN, JINGYU/0000-0002-1609-6890;
   Bressington, Daniel/0000-0003-0951-2208; Liu,
   Xian-Liang/0000-0002-3296-5339; WANG, Tao/0000-0001-9845-3988
FU Charles Darwin University Rainmaker Readiness Grant
FX This study is supported by the Charles Darwin University Rainmaker
   Readiness Grant (2018) and the Grant number is not applicable.
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NR 63
TC 11
Z9 11
U1 6
U2 43
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1462-3889
EI 1532-2122
J9 EUR J ONCOL NURS
JI Eur. J. Oncol. Nurs.
PD OCT
PY 2023
VL 66
AR 102380
DI 10.1016/j.ejon.2023.102380
EA AUG 2023
PG 12
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA R3YC7
UT WOS:001063729300001
PM 37607468
OA Bronze
DA 2026-01-16
ER

PT J
AU Zhang, N
   Li, JL
   Yan, CQ
   Wang, X
   Lin, LL
   Tu, JF
   Qi, YS
   Liu, JH
   Liu, CZ
   Wang, LQ
AF Zhang, Na
   Li, Jin-Ling
   Yan, Chao-Qun
   Wang, Xu
   Lin, Lu-Lu
   Tu, Jian-Feng
   Qi, You-Sheng
   Liu, Jun-Hong
   Liu, Cun-Zhi
   Wang, Li-Qiong
TI The cerebral mechanism of the specific and nonspecific effects of
   acupuncture based on knee osteoarthritis: study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Specific effect; Nonspecific effect; Acupuncture; Knee osteoarthritis;
   Functional magnetic resonance imaging; Clinical trial
ID SHAM ACUPUNCTURE; BREAST-CANCER; PLACEBO; PAIN; BRAIN; WOMEN; POWER;
   FMRI; ELECTROACUPUNCTURE; REGIONS
AB BackgroundResearch on the effect of acupuncture has been limited. Whether the effect of acupuncture is equivalent to placebo has been the focus of debate in this field. This study will explore the specific and non-specific effects of acupuncture for knee osteoarthritis (KOA) by functional magnetic resonance imaging (fMRI).Methods and designNinety participants diagnosed with KOA will be randomly divided into the acupuncture group, sham acupuncture group, and waiting list group in a ratio of 1:1:1. Except for the waiting list group, the other participants will receive acupuncture or sham acupuncture three sessions per week for 4weeks respectively. The primary outcome will be the response rate which is defined on an individual basis as at least a 2-point decrease in the numerical rating scale (NRS) of pain at the end of intervention period compared with the baseline. fMRI scans will be performed at baseline and the end of the intervention period to examine the response of various brain regions. The secondary outcomes will include the Western Ontario and McMaster Osteoarthritis Index (WOMAC), State-Trait Anxiety Scale-State Anxiety Subscale (STAI-S), and Stanford Expectations of Treatment Scale (SETS). Pearson's correlation coefficient will be performed to investigate the changes in brain activity and clinical variables.DiscussionThe results of our study will help to evaluate the specific and nonspecific effects of acupuncture combined with clinical and brain function changes based on KOA.Trial registrationChinese Clinical Trial Registry ChiCTR1900025799. Registered on 9 September 2019.
C1 [Zhang, Na] Shandong Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Jinan, Shandong, Peoples R China.
   [Zhang, Na; Li, Jin-Ling; Yan, Chao-Qun; Lin, Lu-Lu; Tu, Jian-Feng; Liu, Cun-Zhi; Wang, Li-Qiong] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Acupuncture Res Ctr, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
   [Wang, Xu] Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China.
   [Qi, You-Sheng; Liu, Jun-Hong] Nanyuan Community Hlth Serv Ctr, Beijing, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Beijing University
   of Chinese Medicine; Beijing University of Chinese Medicine
RP Wang, LQ (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Acupuncture Res Ctr, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
EM wangliqiongwork@163.com
RI Lin, Lulu/JSL-6136-2023; Liu, Cunzhi/J-9190-2017; Tu,
   Jian-Feng/J-7768-2017; li, jinling/HRD-0858-2023
FU Beijing Municipal Science & Technology Commission [D171100003217003]
FX The study is supported by Beijing Municipal Science & Technology
   Commission (D171100003217003).
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NR 46
TC 2
Z9 4
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 23
PY 2020
VL 21
IS 1
DI 10.1186/s13063-020-04518-5
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MF9UK
UT WOS:000545682400005
PM 32576243
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhou, R
   Zhu, YJ
   He, YH
   Lin, JJ
   Zhang, ZX
   Zhao, WJ
   Ma, HC
   Chang, XS
   Chen, YD
   Li, WZ
   Chen, X
   Chai, XS
   Zhang, HB
AF Zhou, Rui
   Zhu, Yan-juan
   He, Yi-han
   Lin, Jia-jia
   Zhang, Ze-xin
   Zhao, Wen-jie
   Ma, Hao-chuan
   Chang, Xue-song
   Chen, Ya-dong
   Li, Wen-zhu
   Chen, Xian
   Chai, Xiao-shu
   Zhang, Hai-bo
TI The association between acupuncture and response to immune checkpoint
   inhibitors in non-small cell lung cancer
SO CHINESE MEDICINE
LA English
DT Article
DE Acupuncture; Immune checkpoint inhibitors; Non-small cell lung cancer;
   Immunotherapy
ID EFFICACY; EVENTS; PAIN
AB Background Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) treatment, yet low response rates and resistance remain challenges. Emerging evidence suggests acupuncture may enhance ICI effectiveness by reprogramming immunosuppressive tumor microenvironments. Methods A retrospective analysis was conducted on 217 ICI-treated NSCLC patients. Patients who initiated acupuncture before median progression-free survival (mPFS, 8.87 months) of the overall population were classified as the acupuncture group (n = 97). Cox regression analysis was employed to evaluate the association between clinical characteristics and outcomes. Propensity score matching (PSM) was performed to mitigate selection bias. Subgroup and interaction analyses were conducted to evaluate potential effect modifiers. Results Acupuncture was significantly associated with improved mPFS (10.23 vs. 7.87 months, P = 0.036), while a numerical trend favoring acupuncture was observed in overall survival (mOS: 24.1 vs. 20.9 months, P = 0.352). Obvious benefits emerged in bone metastasis patients, with the acupuncture group reducing progression risk by 76% (HR = 0.24, 95% CI 0.14-0.42, P < 0.001) and death risk by 53% (HR = 0.47, 95% CI 0.21-1.03, P = 0.049). Conversely, PD-L1-positive subgroups exhibited no trend of improvement (subgroup HR > 1.0), with interaction HRs > 2.0 indicating potential impairment of ICI efficacy. The results of post-PSM data suggest that acupuncture was independently associated with improved PFS (aHR = 0.62, 95% CI 0.41-0.94, P = 0.024). Conclusion Our findings suggest a positive association between acupuncture and improved outcomes in ICI-treated NSCLC patients, particularly in those with bone metastasis, underscoring the potential role of acupuncture in the integrative management of cancer. However, biomarker-guided patient stratification is essential for integrating acupuncture into oncology care.
C1 [Zhou, Rui; Zhu, Yan-juan; He, Yi-han; Ma, Hao-chuan; Chang, Xue-song; Chen, Ya-dong; Li, Wen-zhu; Chen, Xian; Chai, Xiao-shu; Zhang, Hai-bo] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Tradit Chinese Med, Dept Oncol, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.
   [Zhu, Yan-juan; Zhang, Hai-bo] Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China.
   [Zhu, Yan-juan; Zhang, Hai-bo] Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.
   [Lin, Jia-jia; Zhang, Ze-xin; Zhao, Wen-jie] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
   [Zhang, Hai-bo] Second Affiliated Hosp Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zhu, YJ; Zhang, HB (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Tradit Chinese Med, Dept Oncol, 111 Dade Rd, Guangzhou 510120, Guangdong, Peoples R China.; Zhu, YJ; Zhang, HB (corresponding author), Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China.; Zhu, YJ; Zhang, HB (corresponding author), Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.; Zhang, HB (corresponding author), Second Affiliated Hosp Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
EM zyjsophy@gzucm.edu.cn; haibozh@gzucm.edu.cn
RI Chang, Xuesong/HGB-8879-2022; Zhang, Haibo/AIA-5872-2022; Lin,
   Jiajia/GWV-8148-2022
FU National Key Research and Development Program of China [2023YFC3503303];
   Major Innovation Technology Construction Project of Synergistic Chinese
   Medicine and Western Medicine of Guangzhou [2023-2318]; Project of
   Guangdong Provincial Hospital of Chinese Medicine [YN2024GZRPY019];
   Traditional Chinese Medicine Bureau of Guangdong Province [20233014]
FX This study was funded by the National Key Research and Development
   Program of China (2023YFC3503303), the Major Innovation Technology
   Construction Project of Synergistic Chinese Medicine and Western
   Medicine of Guangzhou (2023-2318), the Project of Guangdong Provincial
   Hospital of Chinese Medicine (YN2024GZRPY019), and the Traditional
   Chinese Medicine Bureau of Guangdong Province (20233014).
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD SEP 19
PY 2025
VL 20
IS 1
AR 145
DI 10.1186/s13020-025-01148-4
PG 12
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 7OR5E
UT WOS:001576021600002
PM 40973957
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Vella, R
   Giardino, A
   Pizzocaro, E
   Frigerio, I
   Bannone, E
   Vieni, S
   Butturini, G
AF Vella, Roberta
   Giardino, Alessandro
   Pizzocaro, Erica
   Frigerio, Isabella
   Bannone, Elisa
   Vieni, Salvatore
   Butturini, Giovanni
TI Unconventional Treatments for Pancreatic Cancer: A Systematic Review
SO CANCERS
LA English
DT Review
DE pancreatic cancer; systematic review; complementary medicine;
   unconventional treatment; precision oncology
ID QUALITY-OF-LIFE; FACTOR-KAPPA-B; VISCUM-ALBUM L; PHASE-I; CHINESE
   MEDICINE; CURCUMIN; PAIN; SURVIVAL; GEMCITABINE; CHEMOTHERAPY
AB Objective: This study aims to review the existing literature on the efficacy and safety of unconventional treatments among pancreatic cancer patients, including the use of natural products, dietary supplements, probiotics, whole medical systems, and body-based therapies. Methods: An electronic, systematic, and comprehensive literature review was conducted searching for studies up to November 2024 following the PRISMA 2020 guidelines. Randomized controlled trials and prospective and retrospective studies assessing the efficacy and safety of unconventional treatments for pancreatic cancer were considered eligible. Data on overall survival, quality of life, and treatment tolerability were extracted. Results: A total of 21 studies, providing data from 3095 patients, met the inclusion criteria. Various types of unconventional treatments are used in pancreatic cancer patients, including Chinese herbal medicine (CHM), mistletoe extract (ME), curcumin, and electroacupuncture. Among these, the use of CHM and curcumin concomitant with standard therapy was associated with survival and quality-of-life benefits. Electroacupuncture reduced pancreatic cancer pain intensity in a cost-effective manner. The data on ME are mixed and of insufficient quality for drawing definitive conclusions. Conclusions: Some unconventional treatments showed potential benefits in improving overall survival and quality of life in pancreatic cancer patients within an integrative oncology setting. Further high-quality studies are needed to provide robust, rigorous, and ethical evidence to support their integration into future guidelines, ensuring a holistic approach to cancer treatment.
C1 [Vella, Roberta; Giardino, Alessandro; Pizzocaro, Erica; Frigerio, Isabella; Bannone, Elisa; Butturini, Giovanni] Pederzoli Hosp, HPB Surg, I-37019 Peschiera Del Garda, Verona, Italy.
   [Vella, Roberta; Vieni, Salvatore] Univ Palermo, Dept Precis Med Med Surg & Crit Care, Me Pre CC, I-90133 Palermo, Italy.
   [Pizzocaro, Erica] Univ Tor Vergata, PhD Sch Appl Med Surg Sci, I-00133 Rome, Italy.
   [Frigerio, Isabella] SAN Univ, Coll Med, PL-90012 Lodz, Poland.
C3 University of Palermo; University of Rome Tor Vergata
RP Pizzocaro, E (corresponding author), Pederzoli Hosp, HPB Surg, I-37019 Peschiera Del Garda, Verona, Italy.; Pizzocaro, E (corresponding author), Univ Tor Vergata, PhD Sch Appl Med Surg Sci, I-00133 Rome, Italy.
EM roberta.vella02@unipa.it; alessandro.giardino@ospedalepederzoli.it;
   erica.pizzocaro@gmail.com; isabella.frigerio@ospedalepederzoli.it;
   elisa.bannone@ospedalepederzoli.it; salvatore.vieni@unipa.it;
   giovanni.butturini@ospedalepederzoli.it
RI ISABELLA, FRIGERIO/ISB-9310-2023; Giardino, Alessandro/AAP-7517-2021;
   BANNONE, ELISA/ABF-3638-2021
OI ISABELLA, FRIGERIO/0000-0002-7616-4226; 
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NR 72
TC 1
Z9 1
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD APR 25
PY 2025
VL 17
IS 9
AR 1437
DI 10.3390/cancers17091437
PG 24
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2MH0N
UT WOS:001486029600001
PM 40361364
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ma, TY
   Xue, GQ
   Zhang, J
   Qin, XY
AF Ma, Taoye
   Xue, Guoqiang
   Zhang, Jie
   Qin, Xiaoyu
TI Effects of acupuncture on postoperative pain in patients undergoing
   breast cancer surgery: A systematic review and meta-analysis
SO ASIAN JOURNAL OF SURGERY
LA English
DT Letter
DE Acupuncture; Postoperative pain; Breast cancer surgery; Systematic
   review; Meta-analysis
C1 [Ma, Taoye] Gansu Prov Cent Hosp, Lanzhou 730070, Gansu, Peoples R China.
   [Ma, Taoye] Gansu Prov Maternal & Child Hlth Hosp, Lanzhou 730050, Gansu, Peoples R China.
   [Xue, Guoqiang] Second Peoples Hosp Gansu Prov, Dept Urol, Lanzhou 730030, Gansu, Peoples R China.
   [Xue, Guoqiang] Northwest Minzu Univ, Affiliated Hosp, Dept Urol, Lanzhou 730030, Gansu, Peoples R China.
   [Zhang, Jie] Gansu Hosp TCM, Anesthesia & Pain Med Ctr, Lanzhou 730050, Gansu, Peoples R China.
   [Qin, Xiaoyu] Shanghai East Hosp, Dept Anesthesiol, Shanghai 200120, Peoples R China.
   [Qin, Xiaoyu] Shanghai East Hosp, Dept Anesthesiol, 551 Pudong South Rd, Shanghai 200120, Peoples R China.
C3 Northwest Minzu University
RP Qin, XY (corresponding author), Shanghai East Hosp, Dept Anesthesiol, 551 Pudong South Rd, Shanghai 200120, Peoples R China.
EM qxyznl@163.com
RI Qin, Xiaoyu/HLW-3930-2023
OI Qin, Xiaoyu/0000-0001-5259-2229
FU Health Industry Research Proj-ect of Gansu Province [GSWSKY2022-37]
FX The study was supported by the Health Industry Research Proj-ect of
   Gansu Province (GSWSKY2022-37) .
CR Abbas DN, 2018, PAIN PHYSICIAN, V21, P351, DOI 10.36076/ppj.2018.4.351
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NR 5
TC 2
Z9 2
U1 0
U2 23
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD NOV
PY 2023
VL 46
IS 11
BP 5029
EP 5031
DI 10.1016/j.asjsur.2023.06.060
EA NOV 2023
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Z1ZN3
UT WOS:001110132900001
PM 37344321
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wan, RH
   Zheng, QH
   Zeng, XR
   Luo, YL
   Sun, LQ
   Chen, S
   Luo, FL
   Zhang, YP
   Zhu, ZY
   Chen, XY
   Zhao, YY
   Li, Y
AF Wan, Renhong
   Zheng, Qianhua
   Zeng, Xiaorui
   Luo, Yalan
   Sun, Luqiang
   Chen, Shuai
   Luo, Fangli
   Zhang, Yupeng
   Zhu, Ziyue
   Chen, Xinyun
   Zhao, Yuanyuan
   Li, Ying
TI Differential placebo effect of sham acupuncture for chronic pain: a
   network meta-analysis of randomized controlled trials
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Manual acupuncture; Sham acupuncture; Placebo; Chronic pain; Randomized
   controlled trial; Meta-analysis
ID TENSION-TYPE HEADACHE; LOW-BACK-PAIN; KNEE OSTEOARTHRITIS; NEEDLE
   ACUPUNCTURE; MULTICENTER; MIGRAINE; FIBROMYALGIA; EFFICACY; DEVICES;
   BLIND
AB BackgroundThe clinical effects of acupuncture are often underestimated due to the placebo effect of sham acupuncture. While multiple sham acupuncture methods have been used in clinical practice, it is challenging to select the appropriate sham acupuncture technique due to the lack of head-to-head trials.PurposeThe purpose of this study was to compare the differential placebo effects of diverse sham acupuncture interventions, providing evidence-based guidance for selecting optimal placebo controls in clinical practice.MethodPubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for randomized controlled trials comparing acupuncture with sham acupuncture for the treatment of chronic non-cancer pain (from inceptions to May 1, 2025). The primary outcome measure was pain variation, while secondary outcome measures included adverse events and the assessment of acupuncture blinding. Frequentist random-effect models were employed to perform indirect treatment comparison meta-analysis, and Confidence in Network Meta-Analysis (CINeMA) was utilized to evaluate the level of evidence.ResultsA total of 45 randomized controlled trials (RCTs) were included, involving 7 sham acupuncture methods and 8287 participants. Regarding pain variation, the difference was noted between the waiting treatment group (mean difference 1.86 (95% confidence interval 1.36 to 2.35), SUCRA 97.4%; moderate confidence of evidence) and manual acupuncture group was most pronounced, followed by the difference between the acupoint and no penetration group (mean difference 1.14 (95% confidence interval 0.74 to 1.55), SUCRA 73.6%; low confidence of evidence) and the nonacupoint and no penetration group (mean difference 1.00 (95% confidence interval 0.35 to 1.65), SUCRA 64.8%; low confidence of evidence). Additionally, the rate of adverse events was comparable among the aforementioned sham acupuncture groups, and the blinding procedure was successfully implemented in the trials.ConclusionsThe placebo effect of sham acupuncture is significant, among which the no penetration (acupoint or nonacupoint) groups exhibited the lowest placebo effect. Nevertheless, further head-to-head trials are warranted to obtain direct evidence.Systematic review registrationPROSPERO no. CRD42024535012.
C1 [Wan, Renhong; Zheng, Qianhua; Zeng, Xiaorui; Sun, Luqiang; Zhang, Yupeng; Zhu, Ziyue; Chen, Xinyun; Zhao, Yuanyuan; Li, Ying] Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
   [Luo, Yalan] Luzhou Longmatan TCM Hosp, Luzhou, Peoples R China.
   [Chen, Shuai] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Nanchang, Jiangxi, Peoples R China.
   [Luo, Fangli] North Sichuan Med Coll, Clin Med Coll Integrated Tradit Chinese & Western, Nanchong, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; North Sichuan Medical University
RP Li, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Chengdu, Peoples R China.
EM liying@cdutcm.edu.cn
RI Luo, Yalan/OEM-8669-2025
FU Chengdu University of Traditional Chinese Medicine "Xinglin Scholar"Team
   Project [XKTD2022008]; General Program of National Natural Science
   Foundation of China [82,474,659]; Sichuan Natural Science Foundation
   Youth Fund Project [24NSFSC4900]
FX This study was supported by the Chengdu University of Traditional
   Chinese Medicine "Xinglin Scholar"Team Project (XKTD2022008), the
   General Program of National Natural Science Foundation of China
   (82,474,659), and the Sichuan Natural Science Foundation Youth Fund
   Project (24NSFSC4900).
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NR 81
TC 1
Z9 1
U1 9
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD SEP 1
PY 2025
VL 25
IS 1
AR 323
DI 10.1186/s12906-025-05055-x
PG 16
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6TL8F
UT WOS:001561619800006
PM 40890765
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Anshasi, HA
   Ahmad, M
AF Anshasi, Huda A.
   Ahmad, Muayyad
TI An assessment of methodological quality of systematic reviews of
   acupuncture and related therapies for cancer-related pain
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Review
DE Acupuncture; Cancer-related pain; Patients with cancer; A systematic
   literature review; Meta-analyses
ID PALLIATIVE CARE; COMPLEMENTARY; MANAGEMENT
AB Background and purpose: There currently exist many systematic reviews aimed at assessing acupuncture and related therapy effectiveness in cancer-related pain management. However, the methodological quality of existing systematic reviews remains unclear. The purpose of this review was to summarize and evaluate the methodological quality of these systematic reviews and meta-analyses papers.
   Methods: A comprehensive search on multiple databases was performed using Assessing the Methodological Quality of Systematic Reviews (AMSTAR).
   Results: Fourteen systematic reviews published between 2005 and 2017 were eligible for inclusion. The consensus across the included reviews was that acupuncture and related therapies alone did not have superior pain-relieving effects as compared with analgesic administration using various validated pain scales. However, as compared with analgesic administration alone, acupuncture and related therapies plus analgesics resulted in reduced cancer related-pain.
   Conclusion: The study findings emphasized that acupuncture and related therapies alone did not have clinically significant effects at cancer-related pain reduction as compared with analgesic administration alone. Clinicians may consider acupuncture and related therapies as adjunctive therapies for cancer-related pain management, in particular, when pain control is unsatisfactory under analgesics alone. Furthermore, the researchers should conduct the SRs and meta-analyses according to the AMSTAR and PRISMA.
C1 [Anshasi, Huda A.; Ahmad, Muayyad] Univ Jordan, Sch Nursing, Amman, Jordan.
C3 University of Jordan
RP Ahmad, M (corresponding author), Univ Jordan, Sch Nursing, Amman, Jordan.
EM anshasi_6@yahoo.com; mma4jo@yahoo.com
RI Ahmad, Muayyad/KYP-8328-2024; Anshasi, Huda/AFL-0862-2022
OI Ahmad, Muayyad/0000-0002-4388-8332; Anshasi, Huda/0000-0003-4853-9825
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NR 45
TC 11
Z9 14
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD AUG
PY 2018
VL 32
BP 163
EP 168
DI 10.1016/j.ctcp.2018.06.013
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GO3OX
UT WOS:000439902900029
PM 30057045
DA 2026-01-16
ER

PT J
AU Chan, YT
   Wang, N
   Tam, CW
   Tan, HY
   Lu, YJ
   So, TH
   Chau-Leung Yu, E
   Lao, LX
   Feng, YB
AF Chan, Yau-Tuen
   Wang, Ning
   Tam, Chi-Wing
   Tan, Hor-Yue
   Lu, Yuanjun
   So, Tsz-Him
   Chau-Leung Yu, Edwin
   Lao, Lixing
   Feng, Yibin
TI Systematic Review with Meta-Analysis: Effectiveness and Safety of
   Acupuncture as Adjuvant Therapy for Side Effects Management in Drug
   Therapy-Receiving Breast Cancer Patients
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID MUSCULOSKELETAL SYMPTOMS; SHAM ACUPUNCTURE; TRIAL; WOMEN;
   ELECTROACUPUNCTURE; CHEMOTHERAPY; PAIN; BENEFITS; EFFICACY; MEDICINE
AB Objective. To investigate the potential benefits and safety of acupuncture on managing side effects induced by drug therapies in patients with breast cancer using a PRISMA standard systematic review and meta-analysis. Methods. Published randomised controlled trials from nine databases in English and Chinese language were searched. Trials with a real acupuncture treatment group and a control group with sham acupuncture, no treatment, or waitlist control were included. The primary outcome of this study was the therapeutic effects on five symptoms induced by drug therapies, including gastrointestinal disorder, neuropathy, arthralgia, joint symptoms, and cognitive impairment. The quality of life was assessed as a secondary outcome. The risk of bias of each study was analysed according to the Cochrane Handbook. Results. Sixteen randomised controlled trials with 1189 participants were included in the meta-analysis. The primary outcome and all subgroup analyses showed statistically significant improvements in the management of side effects by real acupuncture. The quality of life of patients has enhanced during the treatment. Conclusion. Although the number of publications is limited, a clear preliminary conclusion could be drawn by the meta-analysis, suggesting the beneficial adjuvant role of acupuncture in patients with breast cancer who receive drug therapies. No serious adverse events were observed from all the RCTs, and the safety of acupuncture is ascertained. More standardised and sophisticated large-scale randomised controlled trials are needed to evaluate the findings further.
C1 [Chan, Yau-Tuen; Wang, Ning; Tam, Chi-Wing; Tan, Hor-Yue; Lu, Yuanjun; Feng, Yibin] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
   [So, Tsz-Him] Univ Hong Kong, Li Ka Shing Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Chau-Leung Yu, Edwin] Hong Kong Assoc Integrat Chinese Western Med, Hong Kong, Peoples R China.
   [Lao, Lixing] Virginia Univ Integrat Med, 9401 Mathy Dr, Fairfax, VA 22031 USA.
C3 University of Hong Kong; University of Hong Kong
RP Feng, YB (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China.
EM ecyt@connect.hku.hk; ckwang@hku.hk; tcw8@connect.hku.hk;
   hyhtan@hkbu.edu.hk; yjlu@connect.hku.hk; sth495@hku.hk;
   yuedwin@yahoo.com; llao@vuim.edu; yfeng@hku.hk
RI So, Tsz-him/U-1240-2019; Lao, Lixing/P-9107-2019; Tan, Hor
   Yue/LSL-4973-2024; Feng, Yibin/I-5245-2012; Wang, Ning/AFK-9867-2022;
   Chan, Yau-Tuen/JJE-3604-2023; LU, Yuanjun/IYT-2154-2023
OI Tan, Hor Yue/0000-0002-9338-2495; Feng, Yibin/0000-0002-0241-670X; Wang,
   Ning/0000-0003-1410-329X; Chan, Yau-Tuen/0000-0002-1592-2492; LU,
   Yuanjun/0000-0001-6757-3020
FU Wong's Donation [200006276]; Gaia Family Trust for Modern Oncology of
   Chinese Medicine [200007008]; Research Grant Council, HKSAR [RGC GRF
   17152116]; Innovation and Technology Commission: The 2nd Phase of
   Integrative Joint Organizational Platform (IJOP) Disease Collaborative
   Panel [200009062]; Health and Medical Research Fund [15162961, 16172751,
   17181101]
FX The study was financially supported by Wong's Donation (project code:
   200006276), the Gaia Family Trust for Modern Oncology of Chinese
   Medicine (project code: 200007008), Research Grant Council, HKSAR
   (project code: RGC GRF 17152116), Innovation and Technology Commission:
   The 2nd Phase of Integrative Joint Organizational Platform
   (IJOP) Disease Collaborative Panel (project code: 200009062), and Health
   and Medical Research Fund (project codes: 15162961, 16172751, and
   17181101).
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NR 40
TC 7
Z9 9
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD OCT 12
PY 2021
VL 2021
AR 9949777
DI 10.1155/2021/9949777
PG 15
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA YO5DI
UT WOS:000747959300013
PM 34675990
OA Green Submitted, hybrid
DA 2026-01-16
ER

PT J
AU Lu, HB
   Ma, RC
   Yin, YY
   Song, CY
   Yang, TT
   Xie, J
AF Lu, Han-Bing
   Ma, Rui-Chen
   Yin, Ying-Ying
   Song, Chun-Yu
   Yang, Ting-Ting
   Xie, Jiao
TI Auricular Acupressure for Improving Sleep Quality in Patients With Lung
   Cancer A Systematic Review and Meta-analysis
SO HOLISTIC NURSING PRACTICE
LA English
DT Article
DE auricular acupressure; lung cancer; meta-analysis; sleep
ID OF-LIFE; SYMPTOM CLUSTERS; SINGLE-BLIND; DISTURBANCE; INSOMNIA; FATIGUE;
   PAIN; INTERVENTIONS; CORTISOL; WOMEN
AB This meta-analysis was conducted to systematically evaluate the efficacy and safety of auricular acupressure on sleep quality in patients with lung cancer. Nine articles with a total of 802 patients were retrieved after searching on 11 electronic databases. Results of the meta-analysis showed that auricular acupressure improved sleep score (standard mean difference: -0.80, 95% confidence intervals: -1.30 to -0.30, P = .002) and reduced sleep disturbance rate (risk ratio: 0.65, 95% confidence intervals: 0.51-0.84, P = .001) and sleep medicine usage (risk ratio: 0.26, 95% confidence intervals: 0.11-0.65, P = .004) significantly. Our review suggests that auricular acupressure is effective and relatively safe in improving sleep quality among patients with lung cancer.
C1 [Lu, Han-Bing; Ma, Rui-Chen; Yin, Ying-Ying; Song, Chun-Yu; Yang, Ting-Ting; Xie, Jiao] Jilin Univ, Sch Nursing, 965 Xinjiang St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University
RP Xie, J (corresponding author), Jilin Univ, Sch Nursing, 965 Xinjiang St, Changchun 130021, Jilin, Peoples R China.
EM lhbbooya@163.com; 1003373360@qq.com; 386235260@qq.com;
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NR 56
TC 10
Z9 10
U1 1
U2 41
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0887-9311
EI 1550-5138
J9 HOLIST NURS PRACT
JI Holist. Nurs. Pract.
PD JUL-AUG
PY 2022
VL 36
IS 4
BP E27
EP E37
DI 10.1097/HNP.0000000000000532
PG 11
WC Integrative & Complementary Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine; Nursing
GA 2D7EP
UT WOS:000811705700002
PM 35708563
DA 2026-01-16
ER

PT J
AU Bas-Cutrina, F
   Loras, C
   Pardo, A
   Ballester-Clau, R
   Huertas, C
   Guarner-Argente, C
   Colan-Hernandez, J
   Consiglieri, CF
   Andujar, X
   González-Huix, F
   Vilanova-Serra, M
   Pardo-Grau, L
   Maisterra, S
   Ruiz-Ramírez, P
   Garcia-Sumalla, A
   Tebé, C
   Videla, S
   Gornals, JB
AF Bas-Cutrina, Francesc
   Loras, Carme
   Pardo, Albert
   Ballester-Clau, Raquel
   Huertas, Carlos
   Guarner-Argente, Carlos
   Colan-Hernandez, Juan
   Consiglieri, Claudia F.
   Andujar, Xavi
   Gonzalez-Huix, Ferran
   Vilanova-Serra, Magdalena
   Pardo-Grau, Laura
   Maisterra, Sandra
   Ruiz-Ramirez, Pablo
   Garcia-Sumalla, Albert
   Tebe, Cristian
   Videla, Sebastia
   Gornals, Joan B.
TI Management of small subepithelial tumors by endoscopic banding without
   resection and single-incision needle-knife-assisted biopsy sampling: a
   prospective multicenter study
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID STROMAL TUMORS; DIAGNOSIS; LIGATION
AB Background and Aims: Endoscopic band ligation (EBL) without resection combined with single-incision needle-knife (SINK) biopsy sampling may have a positive impact on small GI subepithelial tumor (SET) management, but the method needs to be tested. The aim was to evaluate the feasibility of this strategy in small-sized SETs.
   Methods: This prospective multicenter observational cohort study in 7 centers included patients with SETs <= 15 mm (confirmed by EUS) between March 2017 and March 2020. The primary outcome was clinical success at 4 weeks, defined as complete SET disappearance on EUS. Secondary outcomes were long-term (1-year) clinical success, technical difficulty level, clinical impact, yield pathology, and safety.
   Results: Of 273 patients screened, 122 (62.3% women; mean age, 60.9 +/- 13.2 years) were included with SETs (mean size, 9 +/- 2.8 mm; gastric location, 77%; superficial layer dependence, 63%). The primary endpoint was achieved in 73.6% of patients (95% confidence interval [CI], 64.8-81.2). At the 1-year follow-up, the success rate was 68.4% (95% CI, 59.1-76.8). A favorable clinical impact was observed in 97 cases (79.5%; 95% CI, 71.3-86.3). Pathology diagnosis was known in 70%. Potentially malignant lesions were present in 24.7%. The related adverse events rate was 4.1% (95% CI, 1.3-9.3; all mild: 2 bleeding, 2 abdominal pain). On multivariable analysis, the <= 10-mm SET group was associated with a greater success rate (1 year, 87%; relative risk, 5.07; 95% CI, 2.63-9.8) and clinical impact rate (92.7%; relative risk, 6.15; 95% CI, 2.72-13.93).
   Conclusions: EBL plus SINK biopsy sampling seems to be feasible and safe, and it may offer a favorable clinical impact in small-sized SETs. In particular, SETs <= 10 mm are the best candidates.
C1 [Bas-Cutrina, Francesc; Consiglieri, Claudia F.; Maisterra, Sandra; Garcia-Sumalla, Albert; Gornals, Joan B.] Hosp Univ Bellvitge, Dept Digest Dis, Endoscopy Unit, Barcelona, Spain.
   [Bas-Cutrina, Francesc; Consiglieri, Claudia F.; Maisterra, Sandra; Garcia-Sumalla, Albert; Tebe, Cristian; Videla, Sebastia; Gornals, Joan B.] Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain.
   [Bas-Cutrina, Francesc; Consiglieri, Claudia F.; Maisterra, Sandra; Garcia-Sumalla, Albert; Videla, Sebastia; Gornals, Joan B.] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
   [Bas-Cutrina, Francesc] Hosp Gen Granollers, Digest Dis Unit, Barcelona, Spain.
   [Loras, Carme; Andujar, Xavi; Ruiz-Ramirez, Pablo] Hosp Univ Mutua Terrassa, Dept Digest Dis, Endoscopy Unit, Barcelona, Spain.
   [Loras, Carme; Andujar, Xavi; Ruiz-Ramirez, Pablo] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
   [Loras, Carme; Gornals, Joan B.] Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain.
   [Pardo, Albert; Vilanova-Serra, Magdalena] Hosp Univ Joan XXIII, IISPV, Tarragona 43005, Spain.
   [Ballester-Clau, Raquel; Gonzalez-Huix, Ferran] Hosp Arnau Vilanova, Dept Digest Dis, Endoscopy Unit, Lleida, Spain.
   [Guarner-Argente, Carlos; Pardo-Grau, Laura] Hosp Univ Doctor Josep Trueta, Endoscopy Unit, Dept Digest Dis, Girona, Spain.
   [Guarner-Argente, Carlos] UAB, Hosp Santa Creu i St Pau, Digest Pathol Serv, Endoscopy Unit, Barcelona, Spain.
   [Colan-Hernandez, Juan] Hosp Badalona Germans Trias & Pujol, Dept Digest Dis, Endoscopy Unit, Barcelona, Spain.
   [Tebe, Cristian] Bellvitge Biomed Res Inst IDIBELL, Stat Advisory Serv, Barcelona, Spain.
   [Videla, Sebastia] Hosp Univ Bellvitge, IDIBELL, Clin Res & Clin Trial Unit UICEC, Barcelona, Spain.
   [Gornals, Joan B.] Univ Barcelona, Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Digest Dis,Endoscopy Unit, Feixa Llarga S-N, Barcelona 08907, Spain.
C3 University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Bellvitge University Hospital; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); University of Barcelona; Hospital
   Universitario Mutua Terrassa; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEREHD; Instituto de Salud Carlos III; UOC Universitat Oberta
   de Catalunya; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); University Hospital Arnau de Vilanova;
   Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Autonomous University of Barcelona; Hospital Germans Trias i Pujol;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); University of
   Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL);
   Bellvitge University Hospital; University of Barcelona; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital
RP Gornals, JB (corresponding author), Univ Barcelona, Hosp Univ Bellvitge, Bellvitge Biomed Res Inst IDIBELL, Dept Digest Dis,Endoscopy Unit, Feixa Llarga S-N, Barcelona 08907, Spain.
RI Guarner-Argente, Carlos/M-7616-2019; Huertas; Huertas Nadal;
   Huertas-Nadal;, Carlos/LWK-0646-2024; Colan-Hernandez, Juan/M-2677-2015;
   H Nadal, Carlos/LWK-0646-2024; Tebé, Cristian/K-1991-2019
OI Guarner-Argente, Carlos/0000-0002-8180-1488; Huertas; Huertas Nadal;
   Huertas-Nadal;, Carlos/0000-0003-2353-098X; Colan-Hernandez,
   Juan/0000-0003-2316-0819; Ruiz-Ramírez, Pablo/0000-0001-6766-3069; LORAS
   ALASTRUEY, CARME/0000-0002-4035-3316; gornals, joan
   b/0000-0001-8857-3556; 
FU Fundacio Mutual Medica, Societat Catalana de Digestologia (SCD);
   Sociedad Espanola de Endoscopia DIgestiva (SEED)
FX We thank E. Mayoral, S. Fernandez, M. Izquierdo, and M. Curieses for
   their clinical assistance and P. Moraleda for her logistical assistance;
   E. Julia for her selfless artwork; E. So-spedra for his advice on the
   responses to CEIm (Comite d'etica de la investigacio amb medicaments)
   amendments; J. Carmezim for his statistical assistance; and CERCA
   Programme/Generalitat de Catalunya for institutional support. Research
   support was provided by Fundacio Mutual Medica, Societat Catalana de
   Digestologia (SCD) , and Sociedad Espanola de Endoscopia DIgestiva
   (SEED) .
CR Bas-Cutrina F, 2020, ENDOSCOPY, V52, pE370, DOI 10.1055/a-1134-4742
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NR 25
TC 3
Z9 4
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD DEC
PY 2023
VL 98
IS 6
BP 911
EP +
DI 10.1016/j.gie.2023.05.057
EA NOV 2023
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CC6Y7
UT WOS:001123102600001
PM 37263361
DA 2026-01-16
ER

PT J
AU Posadzki, P
   Moon, TW
   Choi, TY
   Park, TY
   Lee, MS
   Ernst, E
AF Posadzki, Paul
   Moon, Tae-Woong
   Choi, Tae-Young
   Park, Tae-Yong
   Lee, Myeong Soo
   Ernst, Edzard
TI Acupuncture for cancer-related fatigue: a systematic review of
   randomized clinical trials
SO SUPPORTIVE CARE IN CANCER
LA English
DT Review
DE Acupuncture; Cancer; Fatigue; Systematic review; Effectiveness
ID MANAGEMENT; PAIN
AB Managing cancer-related fatigue (CRF) is an important element of the palliative care of cancer patients. The aim of this systematic review was to critically evaluate the effectiveness of acupuncture (AT) or electroacupuncture (EA) for CRF.
   Fourteen databases were searched from their respective inception to November 2012. Randomized clinical trials (RCTs) of AT or EA for the treatment of CRF were considered for inclusion. The risk of bias/methodological quality was assessed using the method suggested by the Cochrane Collaboration.
   Seven RCTs met the eligibility criteria. Most were small pilot studies with serious methodological flaws. Four of the RCTs showed effectiveness of AT or AT in addition to usual care (UC) over sham AT, UC, enhanced UC, or no intervention for alleviating CRF. Three RCTs showed no effect of AT/EA over sham treatment.
   Overall, the quantity and quality of RCTs included in the analysis were too low to draw meaningful conclusions. Even in the positive trials, it remained unclear whether the observed outcome was due to specific effects of AT/EA or nonspecific effects of care. Further research is required to investigate whether AT/EA demonstrates specific effects on CRF.
C1 [Posadzki, Paul; Moon, Tae-Woong; Choi, Tae-Young; Park, Tae-Yong; Lee, Myeong Soo] Korea Inst Oriental Med, KM Hlth Technol Res Grp, Div Med Res, Taejon 305811, South Korea.
   [Posadzki, Paul; Lee, Myeong Soo; Ernst, Edzard] Univ Exeter, Peninsula Med Sch, Exeter, Devon, England.
C3 Korea Institute of Oriental Medicine (KIOM); University of Exeter
RP Posadzki, P (corresponding author), Univ Exeter, Peninsula Med Sch, Exeter, Devon, England.
EM paul.posadzki@pcmd.ac.uk
RI ; Choi, TaeYoung/PAU-6282-2025; Lee, Myeong Soo/C-8147-2013
OI Choi, Tae-Young/0000-0003-0638-2153; Lee, Myeong Soo/0000-0001-6651-7641
FU KIOM [K12130, C12080]
FX PP, TWM, TYC, TYP, and MSL were supported by KIOM (K12130, C12080).
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NR 25
TC 42
Z9 51
U1 0
U2 31
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD JUL
PY 2013
VL 21
IS 7
BP 2067
EP 2073
DI 10.1007/s00520-013-1765-z
PG 7
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 155ME
UT WOS:000319751500034
PM 23435597
DA 2026-01-16
ER

PT J
AU Gruenbaum, SE
   Meng, LZ
   Bilotta, F
AF Gruenbaum, Shaun E.
   Meng, Lingzhong
   Bilotta, Federico
TI Recent trends in the anesthetic management of craniotomy for
   supratentorial tumor resection
SO CURRENT OPINION IN ANESTHESIOLOGY
LA English
DT Review
DE craniotomy; neuroanesthesia; neurosurgery; supratentorial tumor
ID AWAKE CRANIOTOMY; PROPOFOL-REMIFENTANIL; SEVOFLURANE; RECOVERY;
   SUFENTANIL
AB Purpose of reviewThe article reviews the recent evidence on the anesthetic management of patients undergoing craniotomy for supratentorial tumor resection.Recent findingsA rapid recovery of neurological function after craniotomy for supratentorial tumor allows for the prompt diagnosis of intracranial complications and possibly an early hospital discharge. Intraoperative esmolol infusion was shown to reduce the anesthetic requirements, and may facilitate a more rapid recovery of neurological function. Outpatient craniotomy for supratentorial tumor resection has been associated with several clinical and economic benefits, but has not gained widespread use because of skepticism and medical-legal concerns. Awake craniotomy is associated with advantageous outcomes compared with surgery under general anesthesia, and is regarded as the standard of care for tumors that reside in or in close proximity to the eloquent brain. Recent studies have demonstrated that intraoperative electroacupuncture, dexmedetomidine, pregabalin, and lidocaine may facilitate postcraniotomy pain management. The use of volatile anesthetic agents in cancer surgery is associated with a worse survival compared with intravenous anesthetics, possibly by hindering immunologic defenses against cancer cells.SummaryRecent evidence has yielded valuable information regarding anesthetic management of patients undergoing supratentorial tumor craniotomy. Despite a plethora of studies that compare short-term outcomes using different anesthetic and analgesic regimens, randomized controlled trials that examine the long-term outcomes (i.e., neurocognitive function, quality of life, tumor recurrence, and survival) that are of particular interest to patients are needed.
C1 [Gruenbaum, Shaun E.; Meng, Lingzhong] Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA.
   [Bilotta, Federico] Sapienza Univ Rome, Dept Anesthesiol Crit Care & Pain Med, Rome, Italy.
C3 Yale University; Sapienza University Rome
RP Gruenbaum, SE (corresponding author), Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA.
EM shaun.gruenbaum@yale.edu
RI Meng, Lingzhong/ABG-8186-2020
FU CTSA from the National Center for Advancing Translational Science, a
   component of the National Institutes of Health (NIH) [UL1 TR000142]
FX S.G. is supported by CTSA Grant Number UL1 TR000142, from the National
   Center for Advancing Translational Science, a component of the National
   Institutes of Health (NIH). The contents herein are solely the
   responsibility of the authors and do not necessarily represent the
   official view of NIH.
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NR 30
TC 28
Z9 40
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0952-7907
EI 1473-6500
J9 CURR OPIN ANESTHESIO
JI Curr. Opin. Anesthesiol.
PD OCT
PY 2016
VL 29
IS 5
BP 552
EP 557
DI 10.1097/ACO.0000000000000365
PG 6
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA DW9TL
UT WOS:000384005500004
PM 27285727
DA 2026-01-16
ER

PT J
AU Hershman, DL
   Unger, JM
   Greenlee, H
   Capodice, J
   Lew, DL
   Darke, A
   Minasian, LM
   Fisch, MJ
   Henry, NL
   Crew, KD
AF Hershman, Dawn L.
   Unger, Joseph M.
   Greenlee, Heather
   Capodice, Jillian
   Lew, Danika L.
   Darke, Amy
   Minasian, Lori M.
   Fisch, Michael J.
   Henry, N. Lynn
   Crew, Katherine D.
TI Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in
   the Treatment of Aromatase Inhibitor-Related Joint Pain A Randomized
   Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID STAGE BREAST-CANCER; PERIPHERAL NEUROPATHY; WOMEN; ARTHRALGIA;
   ELECTROACUPUNCTURE; DULOXETINE; MANAGEMENT; SYMPTOMS; OUTCOMES; THERAPY
AB IMPORTANCE Aromatase inhibitors (Als) have proven efficacy for the treatment of hormone-sensitive breast cancer; however, arthralgias (pain and stiffness) contribute to nonadherence with therapy for more than 50% of patients.
   OBJECTIVE To examine the effect of acupuncture in reducing Al-related joint pain through 52 weeks.
   DESIGN, SETTING, AND PARTICIPANTS A randomized clinical trial was conducted at 11 sites in the US from May 1, 2012, to February 29, 2016, with a scheduled final date of follow-up of September 5, 2017, to compare true acupuncture (TA) with sham acupuncture (SA) or waiting list control (WC). Women with early-stage breast cancer were eligible if they were taking an Al and scored 3 or higher on the Brief Pain Inventory Worst Pain (BPI-WP) item (score range, 0-10; higher scores indicate greater pain). Analysis was conducted for data received through May 3, 2021.
   INTERVENTIONS Participants were randomized 2:1:1 to the TA (n = 110), SA (n = 59), or WC (n = 57) group. The TA and SA protocols were composed of 6 weeks of intervention at 2 sessions per week (12 sessions overall), followed by 6 additional weeks of intervention with 1 session per week. Participants randomized to WC received no intervention. All participants were offered 10 acupuncture sessions to be used between weeks 24 and 52.
   MAIN OUTCOMES AND MEASURES In this long-term evaluation, the primary end point was the 52-week BPI-WP score, compared by study group using linear regression, adjusted for baseline pain and stratification factors.
   RESULTS Among 226 randomized women (mean [SD] age, 60.7 [8.6] years; 87.7% White; mean [SD] baseline BPI-WP score, 6.7 [1.5]). 191(84.5%) completed the trial. In a linear regression, 52-week mean BPI-WP scores were 1.08 (95% CI, 0.24-1.91) points lower in the TA compared with the SA group (P = .01) and were 0.99 (95% CI, 0.12-1.86) points lower in the TA compared with the WC group (P = .03). In addition. 52-week BPI pain interference scores were statistically significantly lower in the TA compared with the SA group (difference, 0.58; 95% CI, 0.00-1.16; P = .05). Between 24 and 52 weeks, 12 (13.2%) of TA, 6 (11.3%) of SA, and 5 (10.6%) of WC patients reported receipt of acupuncture.
   CONCLUSIONS AND RELEVANCE In this randomized clinical trial, women with Al-related joint pain receiving 12 weeks of TA had reduced pain at 52 weeks compared with controls, suggesting long-term benefits of this therapy.
C1 [Hershman, Dawn L.; Crew, Katherine D.] Columbia Univ, Irving Med Ctr, 161 Ft Washington Ave,10th Floor,Room 1068, New York, NY 10032 USA.
   [Unger, Joseph M.; Greenlee, Heather; Lew, Danika L.; Darke, Amy] Fred Hutchinson Canc Ctr, Seattle, WA USA.
   [Unger, Joseph M.; Lew, Danika L.; Darke, Amy] SWOG Stat & Data Management Ctr, Washington, WA USA.
   [Capodice, Jillian] Mt Sinai Hosp, Dept Urol, New York, NY 10029 USA.
   [Minasian, Lori M.] NCI, Div Canc Prevent, Bethesda, MD 20892 USA.
   [Fisch, Michael J.] AIM Specialty Hlth, Chicago, IL USA.
   [Henry, N. Lynn] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA.
C3 Columbia University; Cornell University; Weill Cornell Medicine;
   NewYork-Presbyterian Hospital; Fred Hutchinson Cancer Center; Southwest
   Oncology Group; Icahn School of Medicine at Mount Sinai; National
   Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI);
   University of Michigan System; University of Michigan
RP Hershman, DL (corresponding author), Columbia Univ, Irving Med Ctr, 161 Ft Washington Ave,10th Floor,Room 1068, New York, NY 10032 USA.
EM dlh23@columbia.edu
RI Hershman, Dawn/AAG-2114-2020; Unger, Joseph/O-7457-2019
OI Henry, N Lynn/0000-0002-4771-5930
FU National Center for Complementary and Integrative Health of the National
   Institutes of Health [R01AT006376, UG1CA189974, U10CA37429]; Office of
   Research onWomen's Health; National Cancer Institute [UG1CA189974]
   Funding Source: NIH RePORTER
FX This study was sponsored by grants R01AT006376, UG1CA189974, and
   U10CA37429 from the National Center for Complementary and Integrative
   Health of the National Institutes of Health and the Office of Research
   onWomen's Health.
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NR 30
TC 43
Z9 49
U1 0
U2 20
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD NOV 11
PY 2022
VL 5
IS 11
AR e2241720
DI 10.1001/jamanetworkopen.2022.41720
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7A3KS
UT WOS:000898360200011
PM 36367721
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shao, JK
   Liu, Q
   Pei, W
   Wang, Y
   Yang, NN
   Qi, LY
   Huang, J
   Yang, JW
   Liu, CZ
AF Shao, Jia-Kai
   Liu, Qian
   Pei, Wei
   Wang, Yu
   Yang, Na-Na
   Qi, Ling-Yu
   Huang, Jin
   Yang, Jing-Wen
   Liu, Cun-zhi
TI Electroacupuncture for postoperative ileus after laparoscopic surgery on
   colorectal cancer: study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Postoperative ileus; Electroacupuncture; Single acupoint; Randomized
   controlled trial
ID OPIOID RECEPTOR ANTAGONIST; ENHANCED RECOVERY; ALVIMOPAN;
   PATHOPHYSIOLOGY; ACUPUNCTURE; DEFINITION; MECHANISMS
AB Background: Postoperative ileus (POI) occurs in almost all patients after abdominal laparoscopic surgery, resulting in complications and increasing the length of hospitalization. Electroacupuncture has been used as an alternative therapy for gastrointestinal dysfunction, but its efficacy for POI is inconclusive. The study is designed to determine whether electroacupuncture can accelerate recovery from POI.
   Methods/design: This study is a three-arm, randomized controlled trial. A total of 105 patients will be randomized into a group receiving electroacupuncture at Tianshu (ST25), a group receiving electroacupuncture at Zusanli (ST36), or a control group in a 1:1:1 ratio. Patients in the electroacupuncture groups will receive electroacupuncture treatment for 4 days from the first day after surgery. The primary outcome consists of the time to first flatus and the time to first defecation. Secondary outcomes include the time to first tolerance of liquid and semiliquid food; the length of the hospital stay; postoperative pain, nausea, and vomiting; abdominal distension; the time to first get out of bed; and postoperative complications. The outcomes will be assessed by the patients themselves every day during hospitalization. Surgeons, nurses, assessors, and statisticians will be blinded to the group assignments. Patients in the two electroacupuncture groups, but not in the control group, will be blinded to the group assignments. The acupuncturists will not be blinded.
   Discussion: The aim of this trial is to provide a nonpharmacological therapy for POI and may provide evidence of the effect of electroacupuncture at ST25 or ST36 on POI.
C1 [Shao, Jia-Kai; Wang, Yu; Yang, Na-Na; Qi, Ling-Yu; Huang, Jin; Yang, Jing-Wen; Liu, Cun-zhi] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Int Acupuncture & Moxibust Innovat Inst, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
   [Liu, Qian; Pei, Wei] Chinese Acad Med Sci, Dept Colorectal Surg, Canc Inst & Hosp, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Chinese Academy of Medical
   Sciences - Peking Union Medical College
RP Yang, JW (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Int Acupuncture & Moxibust Innovat Inst, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
EM yangjw0626@126.com
RI Liu, Cunzhi/J-9190-2017; Wang, Yu/KZU-7684-2024; PEI, WEI/HNC-0257-2023
OI PEI, WEI/0000-0001-5201-6432
FU National Science Fund for Distinguished Young Scholars [81825024];
   Project of National Natural Science Foundation of China [2019YFC1712100]
FX This study was supported by the National Science Fund for Distinguished
   Young Scholars (No: 81825024) and the Project of National Natural
   Science Foundation of China (No: 2019YFC1712100). The sponsor has no
   role in the design of the study; collection, management, analysis, and
   interpretation of data; or the decision to write a report or submit a
   report for publication.
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NR 40
TC 7
Z9 9
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD SEP 9
PY 2021
VL 22
IS 1
AR 610
DI 10.1186/s13063-021-05564-3
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UO7TC
UT WOS:000694894400002
PM 34503565
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shi, YM
   Nguyen, T
   Farrell, M
   Rodgers-Melnick, S
   Moss, G
   Kaiser, C
   Dusek, JA
   Mendiratta, P
   Adan, F
   Lee, RT
AF Shi, Yuming
   Nguyen, Thuy
   Farrell, Megan
   Rodgers-Melnick, Samuel
   Moss, Gabriel
   Kaiser, Christine
   Dusek, Jeffery A. A.
   Mendiratta, Prateek
   Adan, Francoise
   Lee, Richard T. T.
TI Retrospective Outcomes of a New Acupuncture Service at a Comprehensive
   Cancer Center
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE acupuncture; cancer; symptom management; integrative oncology
ID EMERGENCY-DEPARTMENT; INTEGRATIVE MEDICINE; PAIN MANAGEMENT; CARE;
   IMPLEMENTATION; SURVIVORS; PROTOCOL
AB Introduction: Among cancer centers, patients' interest in acupuncture is growing, in addition to clinical research in the intervention. Their National Cancer Institute-designated comprehensive cancer center piloted an acupuncture service. Their aim was to assess whether acupuncture impacted patient self-reported symptoms as delivered clinically and discuss their implementation strategy.Methods: Patients undergoing acupuncture at a comprehensive cancer center from June 2019 to March 2020 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS) before and after each session. The authors evaluated symptom changes after acupuncture in both outpatient and inpatient settings. A change of >= 1 U, on the 0-10 scale, was considered clinically significant.Results: Three hundred and nine outpatient and 394 inpatient acupuncture sessions were provided to patients at the comprehensive cancer center during this period, of which surveys from 186 outpatient (34 patients) and 124 inpatient (57 patients) sessions were available for analysis. The highest pretreatment symptoms reported by outpatients were neuropathy (5.78), pain (5.58), and tiredness (5.59). Outpatients receiving acupuncture reported clinically significant improvements in pain (ESAS score change of -2.97), neuropathy (-2.68), decreased lack of well-being (-2.60), tiredness (-1.85), nausea (-1.83), anxiety (-1.56), activities of daily living issues (-1.32), depression (-1.23), anorexia (-1.19), insomnia (-1.14), and shortness of breath (-1.14). The most severe pretreatment symptoms reported by inpatients were pain (6.90), insomnia (6.16), and constipation (5.44). Inpatients receiving acupuncture reported clinically significant improvements in anxiety (-3.69), nausea (-3.61), insomnia (-3.26), depression (-2.98), pain (-2.77), neuropathy (-2.68), anorexia (-2.20), constipation (-1.95), and diarrhea (-1.26).Conclusion: Both outpatient and inpatient participants in this pilot acupuncture program reported clinically significant improvements in symptoms after a single acupuncture treatment. Some differences between the outpatient and inpatient settings warrant further investigation.
C1 [Shi, Yuming; Farrell, Megan; Rodgers-Melnick, Samuel; Moss, Gabriel; Dusek, Jeffery A. A.; Mendiratta, Prateek; Adan, Francoise; Lee, Richard T. T.] Case Western Reserve Univ, Cleveland, OH USA.
   [Nguyen, Thuy; Rodgers-Melnick, Samuel; Kaiser, Christine; Dusek, Jeffery A. A.; Adan, Francoise] Univ Hosp Connor Whole Hlth, Cleveland, OH USA.
   [Nguyen, Thuy] Cleveland Clin, Cleveland, OH USA.
   [Mendiratta, Prateek; Lee, Richard T. T.] Univ Hosp Cleveland Med Ctr, Cleveland, OH USA.
   [Lee, Richard T. T.] City Hope Comprehens Canc Ctr, Dept Support Care Med, Integrat Med Program, Duarte, CA USA.
   [Lee, Richard T. T.] City Hope Comprehens Canc Ctr, Dept Med Oncol, Integrat Med Program, Duarte, CA USA.
   [Lee, Richard T. T.] City Hope Comprehens Canc Ctr, Dept Support Care Med, Integrat Med Program, Duarte, CA 91010 USA.
   [Lee, Richard T. T.] City Hope Comprehens Canc Ctr, Dept Med Oncol, Integrat Med Program, Duarte, CA 91010 USA.
C3 University System of Ohio; Case Western Reserve University; Cleveland
   Clinic Foundation; University Hospitals of Cleveland; City of Hope; City
   of Hope; City of Hope; City of Hope
RP Lee, RT (corresponding author), Case Western Reserve Univ, Cleveland, OH USA.; Lee, RT (corresponding author), Univ Hosp Cleveland Med Ctr, Cleveland, OH USA.; Lee, RT (corresponding author), City Hope Comprehens Canc Ctr, Dept Support Care Med, Integrat Med Program, Duarte, CA 91010 USA.; Lee, RT (corresponding author), City Hope Comprehens Canc Ctr, Dept Med Oncol, Integrat Med Program, Duarte, CA 91010 USA.
EM richlee@coh.org
RI Rodgers-Melnick, Samuel/ABK-4891-2022; Lee, Richard/AAS-1416-2021
OI Dusek, Jeffery/0000-0001-9581-0564; Lee, Richard/0000-0001-9916-6155
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NR 34
TC 4
Z9 4
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD OCT 1
PY 2023
VL 29
IS 10
BP 674
EP 682
DI 10.1089/jicm.2022.0709
EA MAY 2023
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA T6SY3
UT WOS:000996906300001
PM 37252748
DA 2026-01-16
ER

PT J
AU Desai, VM
   Priya, S
   Gorantla, S
   Singhvi, G
AF Desai, Vaibhavi Meghraj
   Priya, Sakshi
   Gorantla, Srividya
   Singhvi, Gautam
TI Revolutionizing Therapeutic Delivery with Microneedle Technology for
   Tumor Treatment
SO PHARMACEUTICS
LA English
DT Review
DE microneedles; tumor therapy; tumor diagnosis; theranostic; chemotherapy
ID TRANSDERMAL DRUG-DELIVERY; PATCH; NANOPARTICLES; PLATFORM; GENE; PAIN
AB The tumor is an uncontrolled growth of tissue that can be localized (benign) or possesses the capability of metastasis (malignant). The conventional methods of tumor diagnosis, such as acupuncture, endoscopy, and histopathology, and treatment methods, such as injections, chemotherapy, surgery, and radiotherapy, are invasive, expensive, and pose severe safety and management issues for the patients. Microneedle technology is a recently developed approach for active transdermal drug delivery. It is minimally invasive, self-administrable, bypasses the first-pass effect, and effectively delivers chemotherapeutics and drugs at low doses, thus, overcoming the drawbacks of conventional delivery systems. This review provides an idea of the types, materials utilized in the fabrication, and techniques used for the preparation of microneedles (MNs), as well as their application in tumor diagnosis and treatment. Additionally, emphasis is given to the case studies related to MNs-assisted tumor therapy, such as photothermal therapy, gene therapy, photodynamic therapy, chemotherapy, immunotherapy, and various combination therapies. MNs also serve as a tool for diagnosis by the bio-sampling of blood and interstitial skin fluid, as well as biosensing various cancer biomarkers. The combined therapy and diagnostics provide theranostic MNs for enhanced and personalized tumor therapy. The limitations and prospects of MNs development are also discussed.
C1 [Desai, Vaibhavi Meghraj; Priya, Sakshi; Gorantla, Srividya; Singhvi, Gautam] Birla Inst Technol & Sci BITS Pilani, Dept Pharm, Ind Res Lab, Pilani Campus, Pilani 333031, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Singhvi, G (corresponding author), Birla Inst Technol & Sci BITS Pilani, Dept Pharm, Ind Res Lab, Pilani Campus, Pilani 333031, India.
EM gautam.singhvi@pilani.bits-pilani.ac.in
RI Priya, Sakshi/OLP-7047-2025
OI Desai, Vaibhavi/0000-0001-9503-7778
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NR 73
TC 23
Z9 23
U1 8
U2 61
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD JAN
PY 2023
VL 15
IS 1
AR 14
DI 10.3390/pharmaceutics15010014
PG 27
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7Z6XY
UT WOS:000915701200001
PM 36678643
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhou, X
   Cao, SG
   Tan, XJ
   Liu, XD
   Li, ZQ
   Kong, LX
   Tian, YL
   Liu, D
   Shen, S
   Sun, YQ
   Jiang, HT
   Zhou, YB
AF Zhou, Xin
   Cao, Shou-Gen
   Tan, Xiao-Jie
   Liu, Xiao-Dong
   Li, Ze-Qun
   Kong, Ling-Xin
   Tian, Yu-Long
   Liu, Dan
   Shen, Shuai
   Sun, Yu-Qi
   Jiang, Hai-Tao
   Zhou, Yan-Bing
TI Effects of Transcutaneous Electrical Acupoint Stimulation (TEAS) on
   Postoperative Recovery in Patients with Gastric Cancer: A Randomized
   Controlled Trial
SO CANCER MANAGEMENT AND RESEARCH
LA English
DT Article
DE stomach neoplasms; acupuncture therapy; enhanced recovery after surgery;
   pain management; gastrointestinal function
ID INDUCED NAUSEA; ELECTROACUPUNCTURE; ACUPUNCTURE; ANALGESIA; SURGERY;
   PAIN; MECHANISMS; RELEASE
AB Purpose: Transcutaneous electrical acupoint stimulation (TEAS) is an innovative choice for postoperative pain management. However, the safety and effectiveness of this traditional Chinese medicine (TCM) therapy for patients who underwent gastrectomy is largely unknown. So, the purpose of this study is to evaluate the safety and effectiveness of TEAS for patients who underwent gastrectomy.
   Patients and Methods: We recruited 96 patients with gastric cancer from May 2019 to November 2019; 82 patients were enrolled, and 81 patients completed. Patients were randomly assigned to TEAS group (TG) received TEAS on postoperative day (POD) 1-3 or control group (CG) at a 1:1 ratio. The primary outcomes were pain score and consumption of analgesics. The secondary were the time of first postoperative flatus and defecation, frequency of postoperative nausea, vomiting, distention, diarrhea, comfort of semi-fluid diet, Clavien-Dindo grade (C-D grade) and length of postoperative day. We performed hematological analysis to explore the possible mechanisms.
   Results: Overall, 81 patients were enrolled included in the analysis. Compared with CG, pain scores in TG were lower on POD 1-5 (average: 2.55 +/- 0.21 vs 3.10 +/- 0.42, P<0.001), and the use rate of opioids was lower (43.9 vs 75.0, P=0.004); time of first postoperative flatus (55.63 +/- 16.74 vs 72.60 +/- 20.92, P<0.001) and defecation (72.20 +/- 16.24 vs 95.78 +/- 17.75, P<0.001) were shorter; the frequency of nausea were fewer (1.88 +/- 1.09 vs 2.58 +/- 0.77, P=0.029) and patients were more comfortable with semi-fluid diet (7.63 +/- 0.63 vs 6.93 +/- 0.69, P<0.001); among the hematologic results, beta-endorphin (beta-End), interleukin-2 (IL-2), motilin (MTL) on POD 3, POD 5 were lower, 5-hydroxytryptamine (5-HT), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) were higher. And no adverse event was reported.
   Conclusion: TEAS can relieve postoperative pain and promote the recovery of gastrointestinal function. Consequently, it can be an adjunctive therapy to enhance postoperative recovery for patients after gastrectomy.
C1 [Zhou, Xin; Cao, Shou-Gen; Tan, Xiao-Jie; Liu, Xiao-Dong; Li, Ze-Qun; Tian, Yu-Long; Liu, Dan; Shen, Shuai; Sun, Yu-Qi; Jiang, Hai-Tao; Zhou, Yan-Bing] Qingdao Univ, Dept Gastrointestinal Surg, Affiliated Hosp, 16 Jiangsu Rd, Qingdao, Shandong, Peoples R China.
   [Kong, Ling-Xin] Qingdao Univ, Dept Rehabil, Affiliated Hosp, Qingdao, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University
RP Zhou, YB (corresponding author), Qingdao Univ, Dept Gastrointestinal Surg, Affiliated Hosp, 16 Jiangsu Rd, Qingdao, Shandong, Peoples R China.
EM zhouyanbing999@aliyun.com
RI Li, Zequn/NRY-4941-2025; Tian, Yulong/MTE-4165-2025; Zhou,
   Yanbing/HZI-4799-2023
OI Li, Zequn/0009-0004-5831-9361; Tian, Yulong/0000-0003-3592-1064; 
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NR 32
TC 40
Z9 46
U1 6
U2 48
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1322
J9 CANCER MANAG RES
JI Cancer Manag. Res.
PY 2021
VL 13
BP 1449
EP 1458
DI 10.2147/CMAR.S292325
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QI8ZD
UT WOS:000619274800001
PM 33603487
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Shi, HX
   Gao, YJ
   Wang, SR
AF Shi, Hao-Xin
   Gao, Yu-Jun
   Wang, Shu-Ren
TI Electroacupuncture in non-surgical management of lumbar spinal stenosis:
   mechanistic potential in attenuating ligamentum flavum thickening via
   inflammatory factor modulation
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE lumbar spinal stenosis; ligamentum flavum thickening;
   electroacupuncture; inflammation; signal pathway
ID B SIGNALING PATHWAY; LOW-BACK-PAIN; MACROPHAGE POLARIZATION; CANAL
   STENOSIS; ACUPUNCTURE; HYPERTROPHY; RAT; PATHOMECHANISM; FIBROSIS;
   INJURY
AB Lumbar Spinal Stenosis (LSS) is a prevalent spinal disorder mainly induced by degenerative changes in the spine, which lead to nerve root compression. This results in symptoms such as lower back pain, numbness of the lower limbs, and difficulty in walking. The thickening of the ligamentum flavum (LF) is a crucial pathological feature of LSS and is closely linked to inflammatory responses. Electroacupuncture (EA), a form of traditional Chinese medical therapy, has garnered increasing recognition in modern medicine in recent years. It has shown notable efficacy in alleviating pain and enhancing function. EA achieves these effects by modulating inflammatory cytokines, reducing pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1le, and interleukin-6 (IL-6), while increasing anti-inflammatory cytokines like interleukin-10 (IL-10). Additionally, EA may inhibit LF thickening by suppressing signaling pathways, specifically the nuclear factor-kappa B (NF-kappa B) pathway, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, and the mitogen-activated protein kinase (MAPK) pathway. Clinical studies indicate that when EA is combined with other treatment modalities, it can significantly reduce pain and improve functional status in patients with LSS, thus enhancing their quality of life. Although the mechanisms underlying the effects of EA in the treatment of LSS warrant further exploration, its ability to regulate inflammatory responses through multiple pathways and promote tissue repair provides new perspectives and directions for the non-surgical management of LSS. This review encapsulates the application of EA in LSS and explores its potential mechanisms in mitigating LF thickening through the modulation of inflammatory cytokines. The aim is to offer a reference for future research and clinical practice.
C1 [Shi, Hao-Xin; Gao, Yu-Jun] Heilongjiang Univ Chinese Med, Grad Sch, Harbin, Peoples R China.
   [Wang, Shu-Ren] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Tradit Orthoped Therapy, Harbin, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine
RP Wang, SR (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Tradit Orthoped Therapy, Harbin, Peoples R China.
EM wsr696969@126.com
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NR 65
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD OCT 30
PY 2025
VL 16
AR 1644394
DI 10.3389/fimmu.2025.1644394
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 9RK7M
UT WOS:001613242900001
PM 41246317
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Zhao, HY
   Liu, LY
   Cai, J
   Cui, YJ
   Xing, GG
AF Zhao, Hong-Yan
   Liu, Ling-Yu
   Cai, Jie
   Cui, Yan-Jun
   Xing, Guo-Gang
TI Electroacupuncture Treatment Alleviates the Remifentanil-Induced
   Hyperalgesia by Regulating the Activities of the Ventral Posterior
   Lateral Nucleus of the Thalamus Neurons in Rats
SO NEURAL PLASTICITY
LA English
DT Article
ID LOCAL-FIELD POTENTIALS; GAMMA-BAND ACTIVITY; SPINAL DORSAL-HORN; BONE
   CANCER PAIN; NEUROPATHIC PAIN; BRAIN; OSCILLATIONS; CORD; CONTRIBUTES;
   MORPHINE
AB Mechanisms underlying remifentanil- (RF-) induced hyperalgesia, a phenomenon that is generally named as opioid-induced hyperalgesia (OIH), still remain elusive. The ventral posterior lateral nucleus (VPL) of the thalamus, a key relay station for the transmission of nociceptive information to the cerebral cortex, is activated by RF infusion. Electroacupuncture (EA) is an effective method for the treatment of pain. This study aimed to explore the role of VPL in the development of OIH and the effect of EA treatment on OIH in rats. RF was administered to rats via the tail vein for OIH induction. Paw withdrawal threshold (PWT) in response to mechanical stimuli and paw withdrawal latency (PWL) to thermal stimulation were tested in rats for the assessment of mechanical allodynia and thermal hyperalgesia, respectively. Spontaneous neuronal activity and local field potential (LFP) in VPL were recorded in freely moving rats using the in vivo multichannel recording technique. EA at 2 Hz frequency (pulse width 0.6 ms, 1-3 mA) was applied to the bilateral acupoints "Zusanli" (ST.36) and "Sanyinjiao" (SP.6) in rats. The results showed that both the PWT and PWL were significantly decreased after RF infusion to rats. Meanwhile, both the spontaneous neuronal firing rate and the theta band oscillation in VPL LFP were increased on day 3 post-RF infusion, indicating that the VPL may promote the development of RF- induced hyperalgesia by regulating the pain-related cortical activity. Moreover, 2 Hz-EA reversed the RF- induced decrease both in PWT and PWL of rats and also abrogated the RF-induced augmentation of the spontaneous neuronal activity and the power spectral density (PSD) of the theta band oscillation in VPL LFP. These results suggested that 2 Hz-EA attenuates the remifentanil- induced hyperalgesia via reducing the excitability of VPL neurons and the low-frequency (theta band) oscillation in VPL LFP.
C1 [Zhao, Hong-Yan; Liu, Ling-Yu; Cai, Jie; Xing, Guo-Gang] Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100083, Peoples R China.
   [Zhao, Hong-Yan; Liu, Ling-Yu; Cai, Jie; Xing, Guo-Gang] Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100083, Peoples R China.
   [Cui, Yan-Jun] Peking Univ Hosp, Dept Internal Med, Beijing 100871, Peoples R China.
   [Xing, Guo-Gang] Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China.
   [Xing, Guo-Gang] Minist Educ, Key Lab Neurosci, Natl Hlth & Family Planning Commiss, Beijing 100083, Peoples R China.
C3 Peking University; Peking University; Peking University; Henan Medical
   University
RP Xing, GG (corresponding author), Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100083, Peoples R China.; Xing, GG (corresponding author), Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100083, Peoples R China.; Cui, YJ (corresponding author), Peking Univ Hosp, Dept Internal Med, Beijing 100871, Peoples R China.; Xing, GG (corresponding author), Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China.; Xing, GG (corresponding author), Minist Educ, Key Lab Neurosci, Natl Hlth & Family Planning Commiss, Beijing 100083, Peoples R China.
EM cyj@pku.edu.cn; ggxing@bjmu.edu.cn
RI cai, jie/HHS-0606-2022; Zhao, Hong-Yan/ABI-5446-2020
OI Zhao, Hong-Yan/0000-0002-5454-2759
FU National Natural Science Foundation of China [81671085, 81371237,
   61527815]; National Basic Research Program of China (973 Program)
   [2013CB531905]; Institute of Acupuncture and Moxibustion, China Academy
   of Chinese Medical Sciences [ZZ04004]
FX The present work was supported by grants from the National Natural
   Science Foundation of China (81671085, 81371237, and 61527815), the
   National Basic Research Program of China (973 Program, 2013CB531905),
   and the open project for the basic research program from the Institute
   of Acupuncture and Moxibustion, China Academy of Chinese Medical
   Sciences (ZZ04004).
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NR 83
TC 17
Z9 18
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PY 2018
VL 2018
AR 6109723
DI 10.1155/2018/6109723
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HB6TL
UT WOS:000451205000001
PM 30534151
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Ao, L
   Shi, JL
   Bai, YW
   Zhang, S
   Gan, JH
AF Ao, Li
   Shi, Jinlin
   Bai, Yaowu
   Zhang, Shan
   Gan, Jianhui
TI Effects of transcutaneous electrical acupoint stimulation on
   perioperative immune function and postoperative analgesia in patients
   undergoing radical mastectomy: A randomized controlled trial
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE transcutaneous electrical acupoint stimulation; breast cancer; radical
   mastectomy; postoperative analgesia; immunity
ID BREAST-CANCER SURGERY; GENERAL-ANESTHESIA; T-CELLS; ACUPUNCTURE;
   ELECTROACUPUNCTURE; PAIN; METASTASIS; PARAMETERS; EXPRESSION; PROGNOSIS
AB Radical mastectomy may lead to suppression of cellular immune function in patients with malignant tumors. Transcutaneous electrical acupoint stimulation (TEAS) is widely used in clinical practice. However, there have been relatively few studies on the effects of TEAS on postoperative analgesia and immune function. The present study aimed to evaluate the effects of TAES on postoperative pain and immune function in patients undergoing radical mastectomy. A total of 65 patients were enrolled and allocated to either receive TEAS or sham TEAS. TEAS was implemented on bilateral Hegu (LI4), Neiguan (PC6) and Zusanli (ST36) acupoints simultaneously for 30 min before induction of anesthesia at 4 and 12 h post-operation. The primary outcomes included visual analogue scale (VAS) scores at 4 h (T-1), 12 h T-2), 24 h (T-3) and 48 h (T-4) post-operation, and serum levels of IL-2, IL-4, IFN-gamma and the IL-2/IL-4 ratio at 30 min before TEAS (T-0), T-1, T-2, T-3 and T-4. Secondary outcomes included the cumulative time of rescue analgesia within 48 h post-surgery, as well as the incidence of postoperative nausea and vomiting (PONV) and pruritus. Compared with the sham TEAS group, postoperative VAS scores at T-2 and T-3, the total consumption of opioids in the patient-controlled analgesia (PCA) pump, pressing times of the PCA pump and the incidences of PONV and headache were significantly lower in the TEAS group. The serum levels of IFN-gamma at T-3 and T-4, and the serum levels of IL-2 and the IL-2/IL-4 ratio at T-2, T-3 and T-4 were higher in the TEAS group compared with the sham TEAS group. By contrast, the serum levels of IL-4 were lower at T-2, T-3 and T-4 in the TEAS group compared with the sham TEAS group. The results indicated that TEAS could improve postoperative analgesia, reduce postoperative consumption of opioids and alleviate postoperative side effects. Simultaneously, TEAS was able to reverse decreased serum levels of IL-2 and IFN-gamma, reduce the level of IL-4 and restore the balance of Th1/Th2, thereby partially attenuating perioperative immune function depression in patients with breast cancer. The current trial was registered prior to participant enrollment at (Clinical Trial no. ChiCTR1800017768).
C1 [Ao, Li; Bai, Yaowu] North China Univ Sci & Technol, Dept Anesthesiol, Tangshan Matern & Child Healthcare Hosp, Tangshan 063000, Hebei, Peoples R China.
   [Shi, Jinlin; Gan, Jianhui] North China Univ Sci & Technol, Dept Anesthesiol, Tangshan Peoples Hosp, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
   [Shi, Jinlin; Gan, Jianhui] North China Univ Sci & Technol, Dept Anesthesiol, Tangshan Canc Hosp, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
   [Zhang, Shan] Hebei Med Univ, Hosp 2, Dept Anesthesiol, Shijiazhuang 050000, Hebei, Peoples R China.
C3 North China University of Science & Technology; North China University
   of Science & Technology; North China University of Science & Technology;
   Hebei Medical University
RP Gan, JH (corresponding author), North China Univ Sci & Technol, Dept Anesthesiol, Tangshan Peoples Hosp, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.; Gan, JH (corresponding author), North China Univ Sci & Technol, Dept Anesthesiol, Tangshan Canc Hosp, 65 Shengli Rd, Tangshan 063000, Hebei, Peoples R China.
EM ganjianhui666@163.com
RI JinLin, Shi/NWH-5237-2025
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NR 64
TC 28
Z9 35
U1 2
U2 35
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2021
VL 21
IS 3
AR 184
DI 10.3892/etm.2021.9615
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PW3BI
UT WOS:000610547700001
PM 33488793
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Strauss, I
   Berger, A
   Arad, M
   Hochberg, U
   Tellem, R
AF Strauss, Ido
   Berger, Assaf
   Arad, Michal
   Hochberg, Uri
   Tellem, Rotem
TI O-Arm-Guided Percutaneous Radiofrequency Cordotomy
SO STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
LA English
DT Article
DE Pain; Percutaneous cordotomy; O-Arm intraoperative imaging system
ID CANCER PAIN; CERVICAL CORDOTOMY; MANAGEMENT
AB Background: Pain is often one of the most debilitating symptoms in patients with advanced oncological disease. Patients with localized pain due to malignancy refractory to medical treatment can benefit from selective percutaneous cordotomy that disconnects the ascending pain fibers in the spinothalamic tract. Objectives: Over the past year, we have been performing percutaneous radiofrequency cordotomy with the use of the O-Arm intraoperative imaging system that allows both 2D fluoroscopy and 3D reconstructed computerized tomography imaging. We present our experience using this technique, focusing on technical nuances and complications. Methods: A retrospective analysis was conducted of all patients who underwent percutaneous cordotomy between March 2016 and March 2017. Results: Nineteen patients underwent percutaneous cordotomy procedures. Two patients developed intraoperative delirium and were unable to tolerate the procedure. In 16 out of 17 completed procedures, we achieved excellent immediate pain relief (94%). At 1 month after operation, 15 of the 17 (88%) patients were pain free, and at 3 months 5 out of 5 patients available for follow-up were still free of their original pain. Mirror pain developed in 6 of the 17 patients (35%), but was mild in 4 of these cases and controlled with medications. We experienced 1 serious complication (6%) of ipsilateral hemiparesis. Conclusion: Percutaneous cordotomy using the O-Arm is safe and effective in the treatment of intractable oncological pain. (c) 2018 S. Karger AG, Basel.
C1 [Strauss, Ido; Berger, Assaf] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Neurosurg, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.
   [Arad, Michal; Tellem, Rotem] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Palliat Care Serv, Tel Aviv, Israel.
   [Hochberg, Uri] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Inst Pain Med, Tel Aviv, Israel.
   [Strauss, Ido] Tel Aviv Sourasky Med Ctr, Neuromodulat Unit, Tel Aviv, Israel.
   [Strauss, Ido; Berger, Assaf; Tellem, Rotem] Tel Aviv Sourasky Med Ctr, Sackler Sch Med, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Strauss, I (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Neurosurg, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.
EM idos@tlvmc.gov.il
OI Strauss, Ido/0000-0002-1988-9685; Berger, Assaf/0000-0003-1198-2807
CR Bain E, 2013, J PALLIAT MED, V16, P901, DOI 10.1089/jpm.2013.0027
   Bellini M, 2016, ANAESTH INTENSIVE TH, V48, P197, DOI 10.5603/AIT.a2014.0070
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NR 17
TC 17
Z9 17
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-6125
EI 1423-0372
J9 STEREOT FUNCT NEUROS
JI Stereotact. Funct. Neurosurg.
PY 2017
VL 95
IS 6
BP 409
EP 416
DI 10.1159/000484614
PG 8
WC Neurosciences; Neuroimaging; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA FX6TQ
UT WOS:000426220600007
PM 29316547
DA 2026-01-16
ER

PT J
AU Yuan, MH
   Wang, XY
   Yan, XY
   Ding, H
   Yi, J
   Xia, HM
   Yu, XQ
AF Yuan, Minghua
   Wang, Xiaoyuan
   Yan, Xiaoyan
   Ding, Hong
   Yi, Jing
   Xia, Hongmei
   Yu, Xueqin
TI Effects of heat-sensitive moxibustion combined with naprapathy and
   warming needle moxibustion combined with naprapathy in patients with
   periarthritis of shoulder
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Heat-sensitive moxibustion; warming needle moxibustion; naprapathy;
   periarthritis of shoulder; shoulder function; inflammatory factor
AB Objective: To evaluate the effects of heat-sensitive moxibustion (HSM) combined with naprapathy and warming needle moxibustion (WNM) combined with naprapathy on shoulder function and serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), tumor necrosis factor-a (TNF-a) and interleukin-2 (IL-2) in patients with periarthritis of shoulder (POS). Methods: From July 2017 to July 2020, sixty patients with POS admitted to our hospital were selected as the study subjects, and divided into HSM group (n=29) receiving HSM combined with naprapathy and WNM group receiving WNM combined with naprapathy (n=31). The changes in shoulder function, degrees of pain and serum levels of CGRP, SP, TNF-a and IL-2 were compared between the two groups. Results: After treatment, the scores of myodynamia, pain, range of motion (ROM) of shoulder joint and activities of daily living (ADLs) were improved in both groups (P<0.05), and the scores in HSM group were remarkably higher than those in WNM group (P<0.05). Visual analogue scale (VAS) scores after 3 courses of treatment were lower than those after 1 and 2 courses of treatment respectively (P<0.05), and the VAS scores in HSM group were markedly lower than those in WNM group after 1, 2, and 3 courses of treatment (P<0.05). After treatment, the serum levels of CGRP, SP, TNF-a and IL-2 were decreased in both groups (P<0.05), and the levels in HSM group were noticeably lower than those in WNM group (P<0.05). Conclusion: HSM combined with naprapathy is superior to WNM combined with naprapathy in inhibition of inflammatory factors of pain and serum inflammatory factors, alleviating the pain and promoting the restoration of shoulder function in patients with POS.
C1 [Yuan, Minghua; Wang, Xiaoyuan; Yan, Xiaoyan; Ding, Hong; Yi, Jing; Xia, Hongmei; Yu, Xueqin] Yichun Peoples Hosp, Rehabil Dept, 88 Zhongshan West Rd, Yichun 336000, Jiangxi, Peoples R China.
RP Yu, XQ (corresponding author), Yichun Peoples Hosp, Rehabil Dept, 88 Zhongshan West Rd, Yichun 336000, Jiangxi, Peoples R China.
EM yuxueqin@21cn.com
RI yan, xiao/JVP-0766-2024
CR Chen BS, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013598
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NR 20
TC 8
Z9 10
U1 1
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 7
BP 7804
EP 7811
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA TT0LI
UT WOS:000680042800012
PM 34377257
DA 2026-01-16
ER

PT J
AU Zick, S
   Schrepf, A
   Hasset, A
   Sen, A
   Harris, R
AF Zick, Suzanna
   Schrepf, Andrew
   Hasset, Afton
   Sen, Ananda
   Harris, Richard
TI Depression, anxiety, and pain as potential mediators and moderators of
   self-administered acupressure's effect on fatigue and sleep quality in
   breast cancer survivors
SO PSYCHO-ONCOLOGY
LA English
DT Meeting Abstract
C1 [Zick, Suzanna; Schrepf, Andrew; Hasset, Afton; Sen, Ananda; Harris, Richard] Univ Michigan, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RI Anand, Amit/D-4232-2013
FU National Institutes of Health [R01 CA151445, 2UL1 TR000433-06]
FX This work was supported by the National Institutes of Health (grant
   numbers R01 CA151445 and 2UL1 TR000433-06).
NR 0
TC 1
Z9 1
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD FEB
PY 2018
VL 27
SU 1
SI SI
MA T53
BP 74
EP 74
PG 1
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Psychology; Biomedical Social Sciences
GA FV8OH
UT WOS:000424845700175
DA 2026-01-16
ER

PT J
AU Zick, SM
   Wyatt, GK
   Murphy, SL
   Arnedt, JT
   Sen, A
   Harris, RE
AF Zick, Suzanna Maria
   Wyatt, Gwen Karilyn
   Murphy, Susan Lynn
   Arnedt, J. Todd
   Sen, Ananda
   Harris, Richard Edmund
TI Acupressure for persistent cancer-related fatigue in breast cancer
   survivors (AcuCrft): a study protocol for a randomized controlled trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Acupressure; Persistent fatigue; Breast cancer; Cancer survivor; Sleep
   quality; Ecological momentary assessment; Traditional Chinese Medicine;
   Actigraphy
ID QUALITY-OF-LIFE; STAGE RENAL-DISEASE; PHYSICAL-ACTIVITY; SLEEP;
   OSTEOARTHRITIS; PREVALENCE; PAIN; ASSOCIATION; DEPRESSION; ACTIGRAPHY
AB Background: Despite high levels of clinically significant persistent cancer related fatigue in breast cancer survivors few treatments are currently available and most pose a significant burden on the part of the woman. Acupressure, a component of Traditional Chinese Medicine, has been shown to decrease fatigue levels by as much as 70% in cancer survivors while being inexpensive, non-toxic and an easy to use intervention. The primary aim of this study was to determine the efficacy of two types of self-administered acupressure (relaxation acupressure and stimulating acupressure), compared to standard of care on fatigue severity. Secondary aims were to evaluate the efficacy of two types of acupressure on sleep and kinetic parameters required for implementation of acupressure in a clinical setting; The purpose of this paper is to share the methodology used including challenges and insights.
   Methods/design: This study is a three group, randomized clinical trial. 375 breast cancer survivors at least 12 months after completion of cancer treatments, with moderate to severe persistent fatigue, are being randomized to one of 3 groups: self-administered relaxation acupressure; self-administered stimulating acupressure; or standard of care. Participants are assessed at baseline, 3 weeks, and 6 weeks followed by a 4-week follow-up period. The primary aim is to examine the effect of 6-weeks of relaxation acupressure compared to stimulatory acupressure or standard of care on fatigue as assessed by: weekly self-report using the Brief Fatigue Inventory; objective daytime physical activity on actigraph; or fatigue patterns assessed 4-times daily using a visual analog scale. Secondary endpoints include depression, anxiety, self-efficacy, and sleep quality.
   Discussion: This study has the potential to develop a low-cost, self-care intervention for the most troubling of late-term effects in breast cancer populations, fatigue. The methods used may lend constructive ideas to other investigators working with this population and/or intervention.
C1 [Zick, Suzanna Maria] Univ Michigan, Dept Family Med, Ann Arbor, MI 48105 USA.
   [Wyatt, Gwen Karilyn] Michigan State Univ, E Lansing, MI 48824 USA.
   [Murphy, Susan Lynn] Univ Michigan, Inst Gerontol, Ann Arbor, MI 48104 USA.
   [Murphy, Susan Lynn] VA Ann Arbor Hlth Care Syst, GRECC, Ann Arbor, MI 48104 USA.
   [Arnedt, J. Todd] Univ Michigan, Ann Arbor, MI 48103 USA.
   [Sen, Ananda] Univ Michigan, Dept Biostat, Dept Family Med, Ann Arbor, MI 48104 USA.
   [Harris, Richard Edmund] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48105 USA.
C3 University of Michigan System; University of Michigan; Michigan State
   University; University of Michigan System; University of Michigan;
   Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Ann Arbor
   Healthcare System; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan
RP Zick, SM (corresponding author), Univ Michigan, Dept Family Med, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
EM szick@med.umich.edu
RI ; Arnedt, J Todd/AAA-8939-2021
OI Murphy, Susan/0000-0001-7924-0012; Arnedt, J Todd/0000-0002-5084-9331
FU NIH [R01CA151445]
FX This study is funded by NIH grant R01CA151445. We would like to thank
   Benjamin Wright, Vinita Verma and Tohfa Khabir for their help in
   revising the study protocol and for recruiting for the study.
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NR 36
TC 16
Z9 23
U1 1
U2 41
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD AUG 21
PY 2012
VL 12
AR 132
DI 10.1186/1472-6882-12-132
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 041DL
UT WOS:000311376700001
PM 22909076
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Chen, YC
   Song, XJ
AF Chen, Yuchen
   Song, Xue-Jun
TI Diabetic Neuropathic Pain: Directions for Exploring Treatments
SO BIOMEDICINES
LA English
DT Review
DE diabetic neuropathy; diabetic neuropathic pain; medication;
   non-pharmacological interventions; targeted treatments
ID SPINAL-CORD STIMULATION; RECEPTOR SIGNALING CONTRIBUTES; DORSAL-ROOT
   GANGLION; BONE CANCER PAIN; EPHB RECEPTOR; PERIPHERAL NEUROPATHY;
   ACTIVATION; EPHRINB; HYPERALGESIA; ACUPUNCTURE
AB Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as mechanical allodynia and thermal hyperalgesia, meaning that their physical and psychological health are severely impaired. Unfortunately, the mechanisms of DNP remain highly elusive, so substantial breakthrough in effective DNP targeted treatments is still clinically challenging. This article will hence summarise the main mechanisms currently known to underlie DNP pathogenesis, along with describing some of the current and potential treatment methods against diabetic neuropathic pain.
C1 [Chen, Yuchen] Imperial Coll London, Fac Med, London SW7 2AZ, England.
   [Chen, Yuchen; Song, Xue-Jun] Southern Univ Sci & Technol, Dept Med Neurosci, Shenzhen 518055, Peoples R China.
   [Song, Xue-Jun] Southern Univ Sci & Technol, SUSTech Ctr Pain Med, Shenzhen 518055, Peoples R China.
C3 Imperial College London; Southern University of Science & Technology;
   Southern University of Science & Technology
RP Song, XJ (corresponding author), Southern Univ Sci & Technol, Dept Med Neurosci, Shenzhen 518055, Peoples R China.; Song, XJ (corresponding author), Southern Univ Sci & Technol, SUSTech Ctr Pain Med, Shenzhen 518055, Peoples R China.
EM yuchen.chen22@imperial.ac.uk; songxuejun@sustech.edu.cn
FU The Foundation of Shenzhen Science and Technology Innovation Committee
FX No Statement Available
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NR 74
TC 8
Z9 9
U1 6
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR
PY 2024
VL 12
IS 3
AR 589
DI 10.3390/biomedicines12030589
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA MD3U3
UT WOS:001191657300001
PM 38540203
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Kim, KH
   Lee, MS
   Choi, SM
   Ernst, E
AF Kim, Kun Hyung
   Lee, Myeong Soo
   Choi, Sun-Mi
   Ernst, Edzard
TI Acupuncture for Treating Uremic Pruritus in Patients with End-Stage
   Renal Disease: A Systematic Review
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
LA English
DT Review
DE Acupuncture; end-stage renal disease; systematic review; uremic
   pruritus; itching
ID DOUBLE-BLIND; BIAS; ITCH; HEMODIALYSIS; ANALGESIA; LOCATION; THERAPY;
   TRIALS; DIARY
AB Uremic pruritus (UP) is a common and bothersome symptom in end-stage renal disease (ESRD) that does not always respond to conventional care. Acupuncture is frequently used for the treatment of a wide range of conditions, but its effects on UP in ESRD patients are unclear. The objective of this review was to evaluate the effectiveness of acupuncture for UP in patients with ESRD. We searched 16 electronic databases from their inception to November 2009. All prospective clinical studies of needle acupuncture for UP in hemodialysis patients with ESRD were included regardless of their design. Risk of bias of the included studies was assessed using the Cochrane criteria. Three randomized controlled trials and three uncontrolled observational studies were included. All of the included trials reported beneficial effects of acupuncture. However; most of the studies showed high risk of bias, which leaves their reports unconvincing. The current evidence is insufficient to show that acupuncture is an effective treatment for UP in patients with ESRD because of suboptimal quality and lack of methodological rigor of included studies. Future trials should overcome the limitations of the currently available evidence. J Pain Symptom Manage 2010;40:117-125. (C) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
C1 [Kim, Kun Hyung; Lee, Myeong Soo; Choi, Sun-Mi] Korea Inst Oriental Med, Acupuncture Moxibust & Meridian Res Ctr, Taejon 305811, South Korea.
   [Lee, Myeong Soo; Ernst, Edzard] Univ Exeter, Peninsula Med Sch, Exeter, Devon, England.
   [Lee, Myeong Soo; Ernst, Edzard] Univ Plymouth, Exeter, Devon, England.
C3 Korea Institute of Oriental Medicine (KIOM); University of Exeter;
   University of Plymouth
RP Lee, MS (corresponding author), Korea Inst Oriental Med, Div Standard Res, Taejon 305811, South Korea.
EM drmslee@gmail.com
RI Lee, Myeong Soo/C-8147-2013; CHOI, SUNMI/AAO-3449-2020
OI Lee, Myeong Soo/0000-0001-6651-7641; 
FU Korea Institute of Oriental Medicine [K09050]
FX Funding support for K.H. Kim, S.-M. Choi, and M.S. Lee was provided by
   the Acupuncture, Moxibustion and Meridian Research Project (K09050) of
   the Korea Institute of Oriental Medicine.
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NR 40
TC 48
Z9 58
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0885-3924
EI 1873-6513
J9 J PAIN SYMPTOM MANAG
JI J. Pain Symptom Manage.
PD JUL
PY 2010
VL 40
IS 1
BP 117
EP 125
DI 10.1016/j.jpainsymman.2009.11.325
PG 9
WC Health Care Sciences & Services; Medicine, General & Internal; Clinical
   Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine;
   Neurosciences & Neurology
GA 629PA
UT WOS:000280210900020
PM 21796811
DA 2026-01-16
ER

PT J
AU Gilmour, J
   Harrison, C
   Asadi, L
   Cohen, MH
   Vohra, S
AF Gilmour, Joan
   Harrison, Christine
   Asadi, Leyla
   Cohen, Michael H.
   Vohra, Sunita
TI Informed Consent: Advising Patients and Parents About Complementary and
   Alternative Medicine Therapies
SO PEDIATRICS
LA English
DT Article
DE complementary therapies; evidence-based practice; acupuncture; nausea;
   neoplasms
ID CHEMOTHERAPY-INDUCED NAUSEA; PEDIATRIC ONCOLOGY; ACUPUNCTURE; PAIN;
   ACUPRESSURE; EFFICACY; CHILDREN; LEGAL
AB Although research on complementary and alternative medicine (CAM) therapies is still limited, systematic reviews have revealed sufficient evidence to conclude that CAM can be effective for certain conditions. In this article we discuss clinicians' responsibilities to inform parents/patients about CAM alternatives and use the example of acupuncture for chemotherapy-induced nausea and vomiting. Chemotherapy-induced nausea and vomiting remain significant adverse effects of cancer therapy, and some patients cannot find relief with standard therapies. When making decisions for a child with a life-threatening illness, parents must consider all reasonable options and decide what is in the child's best interests. A physician's failure to provide parents with relevant information regarding therapies with the prospect of therapeutic benefit impedes their ability to make an informed decision. Physicians have the ethical duty of beneficence; they must be aware of current research in pain and symptom management and other aspects of care. A physician's duty of care does not necessarily include the obligation to provide information about therapies outside the range of conventional treatment or those not yet supported in the medical literature. However, as CAM therapies such as acupuncture become better studied and their safety and efficacy are established, the scope of disclosure required may expand to include them. The legal and ethical obligation to obtain informed consent to treatment requires disclosure and discussion of therapies when there is reliable evidence of potential therapeutic benefit. At the same time, the more limited state of knowledge regarding effects of a particular therapy in the pediatric population must be factored into decision-making when treating a child. Pediatrics 2011;128:S187-S192
C1 [Gilmour, Joan] York Univ, Osgoode Hall Law Sch, Toronto, ON M3J 2R7, Canada.
   [Harrison, Christine] SickKids Hosp, Dept Bioeth, Toronto, ON, Canada.
   [Asadi, Leyla] Univ Alberta, Dept Med, Fac Med, Edmonton, AB, Canada.
   [Vohra, Sunita] Univ Alberta, Dept Pediat, Fac Med, Edmonton, AB, Canada.
   [Cohen, Michael H.] Fenton Nelson LLP, Los Angeles, CA USA.
   [Vohra, Sunita] Stollery Childrens Hosp, CARE Program Integrat Hlth & Healing, Edmonton, AB, Canada.
C3 York University - Canada; University of Toronto; Hospital for Sick
   Children (SickKids); University of Alberta; University of Alberta;
   Stollery Children's Hospital
RP Vohra, S (corresponding author), Edmonton Gen Hosp, 8B19-11111 Jasper Ave, Edmonton, AB T5K 0L4, Canada.
EM svohra@ualberta.ca
RI Vohra, Sunita/F-5755-2016; Asadi, Leyla/H-3282-2016
OI Vohra, Sunita/0000-0002-6210-7933; 
FU SickKids Foundation (Toronto, Ontario, Canada); Alberta Heritage
   Foundation for Medical Research; Canadian Institutes of Health Research
FX Funding for this project was partially provided by the SickKids
   Foundation (Toronto, Ontario, Canada). Dr Vohra received salary support
   from the Alberta Heritage Foundation for Medical Research and the
   Canadian Institutes of Health Research.
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NR 45
TC 25
Z9 26
U1 1
U2 12
PU AMER ACAD PEDIATRICS
PI Itasca
PA 345 Park Boulevard, Itasca, IL, UNITED STATES
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD NOV
PY 2011
VL 128
SU 4
BP S187
EP S192
DI 10.1542/peds.2010-2720H
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 846RW
UT WOS:000296921900007
PM 22045862
OA Bronze
DA 2026-01-16
ER

PT J
AU Choi, H
   Gao, S
   Schlaeger, JM
   Patil, CL
   Doorenbos, AZ
   Sullivan, K
   Lif, N
   Li, HJ
AF Choi, Hannah
   Gao, Shuang
   Schlaeger, Judith M.
   Patil, Crystal L.
   Doorenbos, Ardith Z.
   Sullivan, Katelyn
   Lif, Natalie
   Li, Hongjin
TI Expectancy Effect of Acupuncture on Cancer-Related Outcomes: A
   Systematic Review
SO ONCOLOGY NURSING FORUM
LA English
DT Review
DE acupuncture; cancer; expectancy; symptom; systematic review
ID BELIEFS; PAIN
C1 [Choi, Hannah; Schlaeger, Judith M.; Sullivan, Katelyn; Li, Hongjin] Univ Illinois, Coll Nursing, Chicago, IL 60607 USA.
   [Gao, Shuang] Univ Illinois, Coll Med, Chicago, IL USA.
   [Patil, Crystal L.] Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, Ann Arbor, MI USA.
   [Doorenbos, Ardith Z.] Univ Illinois, Dept Biobehav Nursing Sci, Chicago, IL USA.
   [Lif, Natalie] Univ Illinois, Dept Human Dev Nursing Sci, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Michigan System; University of Michigan; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital
RP Choi, H (corresponding author), Univ Illinois, Coll Nursing, Chicago, IL 60607 USA.
EM hchoi213@uic.edu
RI schlaeger, judith/N-4482-2017; Patil, Crystal/H-7509-2016
OI Choi, Hannah/0000-0002-1278-7969; Patil, Crystal/0000-0003-4536-4599
FU National Center for Complementary and Integrative Health [R34 AT012084];
   National Cancer Institute [R21 CA277153]
FX This research was funded, in part, by a grant from the National Center
   for Complementary and Integrative Health (R34 AT012084) and a grant from
   the National Cancer Institute (R21 CA277153) .
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NR 71
TC 2
Z9 2
U1 2
U2 4
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD NOV
PY 2024
VL 51
IS 6
DI 10.1188/24.ONF.547-564
PG 18
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA N1T3V
UT WOS:001362237300007
PM 39431691
DA 2026-01-16
ER

PT J
AU Lyu, Z
   Shen, QY
   Tian, SX
   Gong, LY
   Lou, HZ
   Bao, GN
   Wu, ZX
   Lu, C
   Zhang, WP
   Huang, R
   Ji, CH
   Zheng, SY
   Pan, W
   Ying, YY
   Jin, JW
   Liang, Y
AF Lyu, Zhengyi
   Shen, Qiongying
   Tian, Shuxin
   Gong, Liyan
   Lou, Haizhou
   Bao, Guanai
   Wu, Zhuoxuan
   Lu, Chao
   Zhang, Weiping
   Huang, Rui
   Ji, Conghua
   Zheng, Siyi
   Pan, Wei
   Ying, Yinyin
   Jin, Jianwei
   Liang, Yi
TI Effects of Patient-Controlled Transcutaneous Electrical Acupoint
   Stimulation on Cancer Induced Bone Pain Relief in Patients with
   Non-Small Cell Lung Cancer: Study Protocol for a Randomized Controlled
   Trial
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE bone cancer pain; TEAS; transcutaneous electrical nerve stimulation;
   patient-controlled analgesia; integrative medicine; home-based treatment
ID CLINICAL-TRIALS; STATES
AB Background: Transcutaneous Electrical Acupoint Stimulation (TEAS) therapy opens up the possibility for individuals with Cancerinduced bone pain (CIBP) to receive a home -based, patient -controlled approach to pain management. The aim of this study is designed to evaluate the efficacy of patient -controlled TEAS (PC -TEAS) for relieving CIBP in patients with non -small cell lung cancer (NSCLC). Methods/Design: This is a study protocol for a prospective, triple -blind, randomized controlled trial. We anticipate enrolling 188 participants with NSCLC bone metastases who are also using potent opioid analgesics from 4 Chinese medical centers. These participants will be randomly assigned in a 1:1 ratio to either the true PC -TEAS or the sham PC -TEAS group. All participants will receive standard adjuvant oncology therapy. The true group will undergo patient -controlled TEAS intervention as needed, while the sham group will follow the same treatment schedule but with non-conductive gel patches. Each treatment course will span 7 days, with a total of 4 courses administered. There will be 4 assessment time points: baseline, the conclusion of weeks 4, 8, and 12. The primary outcome of this investigation is the response rate of the average pain on the Brief Pain Inventory (BPI) scale at week 4 after treatment. Secondary outcomes include pain related indicators, quality of life scale, mood scales, and routine blood counts on the assessment days. Any adverse events will be promptly addressed and reported if they occur. We will manage trial data using the EDC platform, with a data monitoring committee providing regular quality oversight. Discussion: PC -TEAS interventions offer an attempt to achieve home -based acupuncture treatment and the feasibility of achieving triple blinding in acupuncture research. This study is designed to provide more rigorous trial evidence for the adjuvant treatment of cancer -related pain by acupuncture and to explore a safe and effective integrative medicine scheme for CIBP. Trial Registration: ClinicalTrials.gov NCT05730972, registered February 16, 2023.
C1 [Lyu, Zhengyi; Shen, Qiongying; Tian, Shuxin; Zheng, Siyi; Pan, Wei] Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Zhejiang, Peoples R China.
   [Gong, Liyan; Bao, Guanai; Lu, Chao] Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China.
   [Lou, Haizhou; Wu, Zhuoxuan] Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Weiping; Ying, Yinyin; Jin, Jianwei; Liang, Yi] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Acupuncture, 219 Moganshan Rd, Hangzhou 310053, Zhejiang, Peoples R China.
   [Huang, Rui] Wenzhou Cent Hosp, Dept Acupuncture & Tuina, Wenzhou, Zhejiang, Peoples R China.
   [Ji, Conghua] Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Cancer Hospital; Zhejiang
   University; Zhejiang Chinese Medical University; Zhejiang Chinese
   Medical University
RP Liang, Y (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Acupuncture, 219 Moganshan Rd, Hangzhou 310053, Zhejiang, Peoples R China.
EM liangyiwww@126.com
RI Lu, Chao/ODK-2866-2025; shen, qiongying/KVB-9873-2024
OI Lu, Chao/0000-0002-0762-5797; 
FU Key Project of Health Science and Technology Program of National Health
   Commission; Zhejiang Province [WKJ-ZJ-2436]; Key Foundation of Chinese
   Medicine Research Program of Zhejiang Province [2021ZZ017]; National
   Natural Science Foundation of China [82174510]; General Scientific
   Research Project from the Education Department of Zhejiang Province
   [Y202248799]
FX This work received support from a grant provided by the Key Project of
   Health Science and Technology Program of National Health Commission and
   Zhejiang Province (Grant No. WKJ-ZJ-2436) , the Key Foundation of
   Chinese Medicine Research Program of Zhejiang Province (2021ZZ017) , the
   National Natural Science Foundation of China (Grant No. 82174510) , and
   the General Scientific Research Project from the Education Department of
   Zhejiang Province (Grant No. Y202248799) . The <STRONG>Funding
   </STRONG>sources had no influence on the design, data collection,
   management, analysis, interpretation of data, or the writing of this
   article, nor did they affect the decision to submit it for publication.
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NR 36
TC 0
Z9 0
U1 4
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2024
VL 17
BP 1285
EP 1298
DI 10.2147/JPR.S437296
PG 14
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MR2B4
UT WOS:001195282400001
PM 38560406
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Mercadante, S
   Lazzari, M
   Reale, C
   Cuomo, A
   Fusco, F
   Marchetti, P
   Mediati, RD
   Chiurazzi, B
   Ciuffedra, L
   Caraceni, A
   Iaffaioli, V
   Luzzani, M
   Micheletto, G
   Papa, A
   Raffaeli, W
   Valle, A
   Caruso, M
   Di Costanzo, F
   Pinato, G
   Nardi, F
   Barni, S
   Natoli, S
   Mammucari, M
   Sabato, AF
   Dauri, M
AF Mercadante, Sebastiano
   Lazzari, Marzia
   Reale, Carlo
   Cuomo, Arturo
   Fusco, Flavio
   Marchetti, Paolo
   Mediati, Rocco D.
   Chiurazzi, Bruno
   Ciuffedra, Libero
   Caraceni, Augusto
   Iaffaioli, Vincenzo
   Luzzani, Massimo
   Micheletto, Giuseppe
   Papa, Alfonso
   Raffaeli, William
   Valle, Alessandro
   Caruso, Michele
   Di Costanzo, Francesco
   Pinato, Gianpaolo
   Nardi, Filippo
   Barni, Sandro
   Natoli, Silvia
   Mammucari, Massimo
   Sabato, Alessandro F.
   Dauri, Mario
CA IOPS Study Group
TI Italian Oncological Pain Survey (IOPS) A Multicentre Italian Study of
   Breakthrough Pain Performed in Different Settings
SO CLINICAL JOURNAL OF PAIN
LA English
DT Article
DE breakthrough pain; cancer pain; rapid-onset opioids; palliative care;
   epidemiology
ID CHRONIC CANCER PAIN; EPISODIC PAIN; PREVALENCE; MANAGEMENT; ADMISSION;
   HOSPICE
AB Objective: A survey of breakthrough pain (BTP) was performed in five palliative care units (PCU), seven oncology departments (ONC), and nine pain clinics (OPC).
   Methods: A standard algorithm was used to confirm the diagnosis of BTP of patients refereed to different settings.
   Results: 1,412 evaluable cancer patients were enrolled. 53.9% were males and the mean age was 63.7 +/- 13.1 years. The mean intensity of background pain was 2.8 +/- 0.73. Patients reported 2.4 +/- 1.1 BTP episodes/ day with a mean intensity of 7.37 +/- 1.28. 80.6% patients reported that the BTP had a significant negative impact in everyday life. The majority of patients reported a fast onset of BTP, which was predictable in 50.7% of cases, while BTP with a gradual onset (> 10 min) was less predictable (29%) (P=0.001). PCU patients were older, had lower Karnofsky levels, a lower number of BTP episodes/ day, a slow onset of BTP onset, and a less predictable BTP. Cancer diagnosis was performed a mean of 23.5 months (SD +/- 32.8) before the assessment. The mean duration of background pain was 3.5 months (SD +/- 3.5), and the mean duration of any analgesic treatment was 2.5 months (SD +/- 3). BTP started a mean of 2.2 months (SD +/- 1.9) before the assessment. Characteristics of BTP were influenced by the course of disease, as well as the duration of background pain and initiation of BTP. Most patients took rapid onset opioids and were satisfied with the treatment. BTP diagnosis was prevalently made by ONC and OPC physicians, and rarely by GPs.
   Conclusion: This survey performed by an Italian observatory expert review group, has confirmed that the BTP represents a clinically relevant condition with a negative impact on the patient's quality of life. BTP was detected in all settings involved. A number of factors are associated with the BTP. Also factors regarding the course of disease and setting of care have been assessed. This information may help in stratifying patients or predicting the risk of development of BTP with specific characteristics.
C1 [Mercadante, Sebastiano] La Maddalena Canc Ctr, Palermo, Italy.
   [Lazzari, Marzia; Natoli, Silvia; Sabato, Alessandro F.; Dauri, Mario] Univ Roma Tor Vergata, Emergency Care Crit Care Med Pain Med & Anesthesi, Rome, Italy.
   [Reale, Carlo] Umberto I Hosp, Anesthesiol Resuscitat & Pain Therapy Dept, Rome, Italy.
   [Marchetti, Paolo] Univ Roma La Sapienza, Rome, Italy.
   [Marchetti, Paolo] IDI IRCCS, Rome, Italy.
   [Mammucari, Massimo] ASL RM F, Rome, Italy.
   [Marchetti, Paolo] IRCCS Fdn Pascale, Natl Canc Inst, Naples, Italy.
   [Chiurazzi, Bruno] AORN A Cardarelli Hosp, Naples, Italy.
   [Papa, Alfonso] Monaldi Hosp, AO Dei Colli, Naples, Italy.
   [Fusco, Flavio] Palliat Care ASL3, Genoa, Italy.
   [Luzzani, Massimo] EO Galliera Hosp, Palliat Care Gerontol & Phys Educ Dept, Genoa, Italy.
   [Mediati, Rocco D.] Careggi Hosp, Dept Oncol, Florence, Italy.
   [Ciuffedra, Libero] AO City Hlth & Sci, Hematol Oncol Ctr Subalpine COES, Molinette, Italy.
   [Valle, Alessandro] FARO Fdn, Turin, Italy.
   [Caraceni, Augusto] IRCCS Fdn Natl Canc Inst Milan, Milan, Italy.
   [Raffaeli, William] Infermi Hosp, Rimini, Italy.
   [Caruso, Michele] Humanitas Oncol Ctr Catania, Catania, Italy.
   [Di Costanzo, Francesco] Careggi Hosp, Florence, Italy.
   [Pinato, Gianpaolo] IRCCS Veneto Oncol Inst, Padua, Italy.
   [Nardi, Filippo] AV3 Macerata Hosp, Macerata, Italy.
   [Barni, Sandro] AO Treviglio, Bergamo, Italy.
   [Caraceni, Augusto] Norwegian Univ Sci & Technol, European Palliat Care Res Ctr, N-7034 Trondheim, Norway.
C3 University of Rome Tor Vergata; Sapienza University Rome; University
   Hospital Sapienza Rome; Sapienza University Rome; IRCCS Istituto
   Dermopatico dell'Immacolata (IDI); IRCCS Fondazione Pascale; Antonio
   Cardarelli Hospital; Ente Ospedaliero Ospedali Galliera; University of
   Florence; Azienda Ospedaliero Universitaria Careggi; Hospital of Rimini;
   University of Florence; Azienda Ospedaliero Universitaria Careggi; IRCCS
   Istituto Oncologico Veneto (IOV); Norwegian University of Science &
   Technology (NTNU)
RP Mercadante, S (corresponding author), La Maddalena Canc Ctr, Palermo, Italy.
EM terapiadeldolore@lamaddalenanet.it
RI Caraceni, Augusto/C-1012-2017; Di Costanzo, Francesco/HMV-6214-2023;
   Natoli, Silvia/AEE-3472-2022; Marchetti, Paolo/K-1469-2016; Raffaeli,
   William/MBH-5858-2025; Dauri, Mario/R-5825-2019; mammucari,
   massimo/AAB-9899-2020; cuomo, arturo/AAL-4416-2020
OI Caraceni, Augusto/0000-0002-0375-6204; Di Costanzo,
   Francesco/0000-0002-6858-7827; Papa, Alfonso/0000-0003-4489-714X;
   Natoli, Silvia/0000-0003-3758-5375; Marchetti,
   Paolo/0000-0002-9064-8761; Raffaeli, William/0000-0003-0240-8993;
   mercadante, sebastiano/0000-0001-9859-6487; Dauri,
   Mario/0000-0001-5592-783X; mammucari, massimo/0000-0002-9515-3549; 
CR Brunelli C, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-42
   Caraceni A, 2004, PALLIATIVE MED, V18, P177, DOI 10.1191/0269216304pm890oa
   Caraceni A, 2012, J PAIN SYMPTOM MANAG, V43, P833, DOI 10.1016/j.jpainsymman.2011.05.018
   Davies A, 2013, J PAIN SYMPTOM MANAG, V46, P619, DOI 10.1016/j.jpainsymman.2012.12.009
   Davies A, 2011, EUR J PAIN, V15, P756, DOI 10.1016/j.ejpain.2010.12.004
   Davies AN, 2008, J PAIN SYMPTOM MANAG, V35, P406, DOI 10.1016/j.jpainsymman.2007.05.010
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NR 24
TC 57
Z9 62
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0749-8047
EI 1536-5409
J9 CLIN J PAIN
JI Clin. J. Pain
PD MAR
PY 2015
VL 31
IS 3
BP 214
EP 221
DI 10.1097/AJP.0000000000000161
PG 8
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA CB2RS
UT WOS:000349476300004
PM 25654429
OA Green Submitted
DA 2026-01-16
ER

PT J
AU Xi, ZQ
   Wei, XQ
   Ye, Z
   Wang, K
   Zhou, J
AF Xi, Ziqi
   Wei, Xuqiang
   Ye, Zi
   Wang, Ke
   Zhou, Jia
TI Acupuncture for adult lung cancer of patient-reported outcomes: A
   systematic review and meta-analysis
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE acupuncture; lung cancer; PROs = patient-reported outcomes; systematic
   review; meta-analysis
ID QUALITY-OF-LIFE; CHEMOTHERAPY-INDUCED NAUSEA; PSYCHOMETRIC ASSESSMENT;
   SLEEP QUALITY; DOUBLE-BLIND; FATIGUE; PAIN; INSTRUMENT; SURGERY; SCALE
AB Purpose: This systematic review and meta-analysis aims to assess the effects of acupuncture on patient-reported outcomes (PROs) in adults with lung cancer. Methods: Electronic databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (CQVIP), Wanfang Data, SinoMed, and gray literatures were retrieved from inception to 1 July 2022 for randomized controlled trials (RCTs). Acupuncture was defined as an experimental intervention, and the patients of the control groups included either treatment including conventional therapy (usual care, sham/placebo acupuncture, pharmacotherapy including Western medicine and Chinese traditional medicine). PROs for this study were measured by seven scales of primary outcomes including the Karnofsky Performance Status (KPS), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Functional Assessment of Cancer Therapy-Lung, Functional Assessment of Cancer Therapy Lung Cancer Subscale, Leicester Cough Questionnaire (LCQ score), the Medical Outcomes Study (MOS) item short form health survey (SF-36), and the St George's Respiratory Questionnaire, and 12 scales of secondary outcomes. Cochrane Collaboration's tool was used to assess the risks of bias. Data were combined and analyzed with RevMan 5.4 and Stata/SE 16.0. Results: We retrieved 3,002 lung cancer patients from 33 trials. KPS included with 1,000 patients showed that acupuncture could significantly improve the quality of life (QOL) compared with the control group regardless of different tumor-node-metastasis stages or the different stages of disease. The study showed that acupuncture significantly improved lung cancer-related symptoms in the QOL, pain, nausea and vomiting, insomnia, anxiety and depression, fatigue, and constipation compared with the control group. Eight RCTs reported the occurrence of adverse events, whereas four reported none and four RCTs reported that the events in the observation group were significantly less than those in the control group. Conclusion: Acupuncture proved to be a promising intervention, both postoperatively and after chemotherapy, and should be recommended as a beneficial alternative strategy to promote PROs in lung cancer patients at all stages of application. Considering the low quality, we suggest more rigorous clinical trials of acupuncture for lung cancer in the future and more emphasis on the effect of acupuncture in patients with lung cancer on their PROs, mainly in the aspect of the QOL.Systematic review registration, identifier [CRD42021274122].
C1 [Xi, Ziqi; Wei, Xuqiang; Ye, Zi; Wang, Ke; Zhou, Jia] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Acupuncture Anesthesia Clin Res Inst, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Wang, K; Zhou, J (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Acupuncture Anesthesia Clin Res Inst, Shanghai, Peoples R China.
EM wangke8430@163.com; pdzhoujia@163.com
RI Ye, Zi/JXM-9859-2024; Wang, Ke/JXN-9969-2024
OI Ye, Zi/0000-0002-3223-5264; Wei, Xuqiang/0000-0001-6008-5681; Wang,
   Ke/0000-0002-5845-7228
FU Project BEBPC-TCM [2019XZZX-ZJ0011]; Shanghai Clinical Research Center
   for Acupuncture and Moxibustion Accelerating [20MC1920500]; Clinical Key
   Specialty Construction Foundation of Shanghai [shslczdzk04701]
FX This study was supported by grants from the Project BEBPC-TCM
   (2019XZZX-ZJ0011); Shanghai Clinical Research Center for Acupuncture and
   Moxibustion Accelerating (20MC1920500); Clinical Key Specialty
   Construction Foundation of Shanghai (shslczdzk04701).
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NR 83
TC 11
Z9 12
U1 0
U2 76
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD SEP 2
PY 2022
VL 12
AR 921151
DI 10.3389/fonc.2022.921151
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 4P2TK
UT WOS:000855249700001
PM 36119472
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Li, FR
   Wan, HJ
   Liu, XH
   Deng, YT
   Tian, WY
   Zhao, ZL
AF Li, Fanrui
   Wan, Hejia
   Liu, Xiaohui
   Deng, Yuanting
   Tian, Wuyang
   Zhao, Zilin
TI Auricular Acupoint Therapy in Symptom Management of Cancer patients: A
   Scoping Review
SO CANCER MANAGEMENT AND RESEARCH
LA English
DT Review
DE auricular point therapy; cancer; symptom management; scoping review
ID SINGLE-BLIND; ACUPUNCTURE; CHEMOTHERAPY; ACUPRESSURE; SLEEP
AB Background: The incidence of cancer is rising annually. With advances in diagnosis and treatment, cancer patients' long-term survival rates have improved, leading them to gradually enter a chronic disease state. However, they frequently experience physiological and psychological symptoms during treatment, which severely impact their survival and quality of life. Auricular acupoint therapy, a green non-pharmacological intervention characterized by ease of operation and low cost, can alleviate cancerrelated symptoms. Despite its widespread use, systematic summarization and comprehensive evaluation of this therapy remain insufficient. Objective: To systematically analyze the application of auricular therapy in cancer patients, identify its characteristics and intervention effects on symptoms, and provide a reference for symptom management in these patients. Methods: Relevant studies were systematically retrieved from PubMed, Web of Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, WanFang Database, and VIP Database from their inception to April 20, 2025. Data from the included literature were extracted and analyzed. Results: A total of 42 studies were included. Auricular therapy is applicable across multiple stages of cancer care and exerts positive effects on cancer-related pain, fatigue, sleep disorders, anxiety, and chemotherapy-induced symptoms. Notably, the pain-fatigue-sleep disorder cluster is the most common and interrelated symptom group, with auricular acupressure as the most frequently used intervention. Conclusion: Owing to its simplicity and cost-effectiveness, auricular therapy offers unique advantages for managing symptoms in cancer patients. The current focus in this field has shifted from managing single symptoms or individual dimensions within symptom clusters to a comprehensive management of symptom clusters. Future research should pay attention to the dynamic progression of symptoms, focus on the core symptom clusters in cancer patients, and optimize intervention strategies to enhance the efficiency of symptom management.
C1 [Li, Fanrui; Wan, Hejia; Liu, Xiaohui; Deng, Yuanting; Tian, Wuyang; Zhao, Zilin] Henan Univ Chinese Med, Sch Nursing, Nursing Sch Smart Healthcare Ind, Zhengzhou, Henan, Peoples R China.
   [Liu, Xiaohui] Henan Univ Tradit Chinese Med, Henan Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Nursing Dept, Zhengzhou, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine
RP Liu, XH (corresponding author), Henan Univ Chinese Med, Sch Nursing, Nursing Sch Smart Healthcare Ind, Zhengzhou, Henan, Peoples R China.; Liu, XH (corresponding author), Henan Univ Tradit Chinese Med, Henan Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Nursing Dept, Zhengzhou, Henan, Peoples R China.
EM 1173652033@qq.com
RI Wan, Hejia/IWD-9214-2023; Zhao, Zilin/KTI-8066-2024
FU Henan Provincial Science and Technology Association Popular Science
   Project [HNKP2025089]; Henan Provincial Health Commission TCM Culture
   and Management Research Project [TCM2023009]; Henan Provincial Health
   Commission TCM Clinical Research Base Special Project [2021JDZX2032];
   Henan Provincial Health Commission TCM Scientific Research Special
   Project [20-21ZY2113]
FX This work was supported by: Henan Provincial Science and Technology
   Association Popular Science Project (HNKP2025089, 2025) . Henan
   Provincial Health Commission TCM Culture and Management Research Project
   (TCM2023009, 2023) . Henan Provincial Health Commission TCM Clinical
   Research Base Special Project (2021JDZX2032, 2022) . Henan Provincial
   Health Commission TCM Scientific Research Special Project (20-21ZY2113,
   2020) .
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1322
J9 CANCER MANAG RES
JI Cancer Manag. Res.
PY 2025
VL 17
BP 3005
EP 3023
DI 10.2147/CMAR.S562388
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA N4222
UT WOS:001631557800001
PM 41362632
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Dymackova, R
   Selingerova, I
   Kazda, T
   Slavik, M
   Halamkova, J
   Svajdova, M
   Slampa, P
   Slama, O
AF Dymackova, Radana
   Selingerova, Iveta
   Kazda, Tomas
   Slavik, Marek
   Halamkova, Jana
   Svajdova, Michaela
   Slampa, Pavel
   Slama, Ondrej
TI Effect of Acupuncture in Pain Management of Head and Neck Cancer
   Radiotherapy: Prospective Randomized Unicentric Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE acupuncture; head and neck cancer; radiotherapy; toxicity; pain
AB This prospective randomized open-label trial aimed to evaluate the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. Patients in two arms (30 patients in each arm) underwent standard oncology therapy and standard supportive care with or without acupuncture. The stratification factors were the type of treatment and chemotherapy indication. The toxicity assessed was represented by pain rated on a 10-point pain scale and analgesic use. Average pain (AP) and the worst pain during the day (WP) were significantly lower in the acupuncture arm during radiotherapy (AP median 0.16 vs. 1.36, p < 0.001; WP median 0.90 vs. 1.96, p < 0.001) and three months after radiotherapy (AP median 0.07 vs. 0.50, p < 0.001; WP median 0.30 vs. 0.83, p = 0.002). The analgesic consumption between arms was statistically significantly different. A median of the proportion of days when the patients used analgesics was 8% and 32.5% during radiotherapy (p = 0.047) and 0% and 20.8% during three months after radiotherapy (p = 0.006) for the acupuncture and control arm, respectively. Results point out lower analgesic consumption and milder pain in acupuncture arm. Acupuncture consequently offers another alternative to standard treatment leading to a reduction in the toxicity of oncological treatment.
C1 [Dymackova, Radana; Slavik, Marek; Svajdova, Michaela] Masaryk Univ, Dept Radiat Oncol, Fac Med, Brno 62500, Czech Republic.
   [Dymackova, Radana; Kazda, Tomas; Slavik, Marek; Slampa, Pavel] Masaryk Mem Canc Inst, Dept Radiat Oncol, Brno 65653, Czech Republic.
   [Selingerova, Iveta; Kazda, Tomas] Masaryk Mem Canc Inst, Res Ctr Appl Mol Oncol RECAMO, Brno 65653, Czech Republic.
   [Halamkova, Jana] Masaryk Univ, Dept Comprehens Canc Care, Fac Med, Brno 62500, Czech Republic.
   [Halamkova, Jana; Slama, Ondrej] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno 65653, Czech Republic.
   [Svajdova, Michaela] Cent Mil Hosp, Clin Radiat & Clin Oncol, Teaching Hosp, Ruzomberok 03401, Slovakia.
C3 Masaryk University; Masaryk Memorial Cancer Institute; Masaryk Memorial
   Cancer Institute; Masaryk University; Masaryk Memorial Cancer Institute
RP Selingerova, I (corresponding author), Masaryk Mem Canc Inst, Res Ctr Appl Mol Oncol RECAMO, Brno 65653, Czech Republic.
EM radana.dymackova@mou.cz; iveta.selingerova@mou.cz; tomas.kazda@mou.cz;
   slavik@mou.cz; jana.halamkova@mou.cz; svajdovam@uvn.sk; slampa@mou.cz;
   oslama@mou.cz
RI ; Selingerová, Iveta/AAF-6396-2019; Kazda, Tomas/AAQ-1740-2020; Slama,
   Onej/AGD-7993-2022; Svajdova, Michaela/ABB-6828-2020
OI Slávik, Marek/0000-0002-8591-5941; Selingerová,
   Iveta/0000-0003-3713-3504; Kazda, Tomas/0000-0001-7288-8975; Slama,
   Onej/0000-0001-9557-3204; Svajdova, Michaela/0000-0002-6372-3295
FU Ministry of Health of the Czech Republic MH CZ-DRO (MMCI) [00209805]
FX This work was supported by the Ministry of Health of the Czech Republic
   MH CZ-DRO (MMCI, 00209805).
CR Alimi D, 2003, J CLIN ONCOL, V21, P4120, DOI 10.1200/JCO.2003.09.011
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NR 20
TC 3
Z9 7
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2021
VL 10
IS 5
AR 1111
DI 10.3390/jcm10051111
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QV9FY
UT WOS:000628269300001
PM 33799949
OA Green Submitted, gold
DA 2026-01-16
ER

PT J
AU Wu, ZH
   Liu, QH
AF Wu, Zanhua
   Liu, Qinghua
TI Effects of repetitive transcranial magnetic stimulation combined with
   acupuncture on NLRP3 inflammasome and protease levels in patients with
   neuropathic pain
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Repetitive transcranial magnetic stimulation; acupuncture; neuropathic
   pain; IGF-1; NLRP3; inflammatory factor
ID MECHANISMS
AB Purpose: This study aimed to investigate whether repetitive transcranial magnetic stimulation (rTMS) combined with acupuncture could alleviate pain in patients suffering from postherpetic neuralgia (PHN) by inhibiting NOD-like receptor 3 (NLRP3) inflammasome activation. Methods: Data of 92 PHN patients were retrospectively collected. The patients were grouped as control (nerve block), rTMS, and rTMS + acupuncture groups according to treatment methods. The visual analogue scale (VAS) score, as well as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, NLRP3, and Caspase-1 levels of patients in each group prior and post-treatment were analyzed. Results: The rTMS + acupuncture group showed higher efficacy than the rTMS group and the control group, contributing to markedly lower VAS score, as well as TNF-alpha, IL-1 beta, IL-6, NLRP3 and Caspase-1 levels than the other two groups (P < 0.05). Conclusion: rTMS plus acupuncture can reduce the inflammatory immune response and ease the pain in patients by inhibiting NLRP3 inflammasome and its resulting inflammatory factors, Caspase-1 and IL-1 beta.
C1 [Wu, Zanhua; Liu, Qinghua] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Rehabil Med, Nanning 530000, Guangxi, Peoples R China.
   [Liu, Qinghua] Hanzhong 3201 Hosp, Dept Orthopaed, Hanzhong 723000, Shaanxi, Peoples R China.
RP Liu, QH (corresponding author), Hanzhong 3201 Hosp, Dept Orthopaed, Hanzhong 723000, Shaanxi, Peoples R China.
EM 2792-286459@qq.com
RI Liu, Qinghua/HCH-3099-2022
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NR 28
TC 5
Z9 8
U1 0
U2 9
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2023
VL 15
IS 7
BP 4699
EP 4708
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA P1YS5
UT WOS:001048673500011
PM 37560225
DA 2026-01-16
ER

PT J
AU Zhang, B
   Xu, F
   Hu, PP
   Zhang, MY
   Tong, KH
   Ma, G
   Xu, YM
   Zhu, L
   Chen, JDDZ
AF Zhang, Bo
   Xu, Feng
   Hu, Pingping
   Zhang, Mingyuan
   Tong, Kehui
   Ma, Gang
   Xu, Yuemei
   Zhu, Liang
   Chen, Jiande D. Z.
TI Needleless Transcutaneous Electrical Acustimulation: A Pilot Study
   Evaluating Improvement in Post-Operative Recovery
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
ID HEART-RATE-VARIABILITY; GASTROINTESTINAL MOTILITY; FUNCTIONAL DYSPEPSIA;
   LAPAROSCOPIC SURGERY; INDUCED IMPAIRMENT; RECTAL DISTENSION; VAGUS
   NERVE; ELECTROACUPUNCTURE; ILEUS; ACUPUNCTURE
AB BACKGROUND: Functional gastrointestinal disturbance occurs after abdominal surgeries and could last for an extended period of time in some cases. This study was designed (1) to evaluate the effects of needleless transcutaneous electrical acustimulation (TEA) on postoperative recovery, and (2) to investigate the mechanisms involving autonomic function in postoperative patients after removal of gastrointestinal cancers.
   METHODS: Forty-two patients (33 male, age: 69.5 +/- 1.5 years) scheduled for abdominal surgical removal of gastrointestinal cancers were randomized to TEA (n = 21) and sham-TEA (n = 21). TEA was performed via acupoints ST36 and PC6 1 h twice daily from the postoperative day (POD) 1 to day 3. Sham-TEA was performed at non-acupoints.
   RESULTS: (1) TEA improved major postoperative symptoms by about 30%, including a reduction in time to defecation by 31.7% (P < 0.01 vs. sham-TEA), time to first flatus by 35.9% (P < 0.001), time to ambulation by 42.8% (P < 0.01), time to resuming diet by 26.5% (P < 0.01) and hospital stay by 30% (P < 0.05) as well as pain score by 50% (P < 0.01). (2) TEA significantly increased vagal activity (P < 0.001) and decreased sympathetic activity on POD 4 (P < 0.001) compared with POD 1 as well as the serum level of NE (P < 0.05). (3) The vagal activity, high frequency assessed from the spectral analysis of heart rate variability, was negatively correlated with time to resuming diet, whereas the sympathetic measurement, serum norepinephrine was positively correlated with time to resuming diet and time to flatus. (4) TEA but not sham-TEA decreased TNF-alpha by 17.4% from POD 1 to POD 4. (5) TEA was an independent predictor of a shorter hospital stay.
   CONCLUSIONS: Needleless TEA improves major postoperative symptoms by enhancing vagal and suppressing sympathetic activities.
C1 [Zhang, Bo; Zhu, Liang] Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China.
   [Zhang, Bo; Ma, Gang; Chen, Jiande D. Z.] Ningbo Pace Translat Med Res Ctr, Ningbo, Zhejiang, Peoples R China.
   [Xu, Feng; Hu, Pingping; Xu, Yuemei] Ningbo Univ, Sch Med, Yinzhou Hosp, Div Gastroenterol, Ningbo, Zhejiang, Peoples R China.
   [Zhang, Mingyuan; Tong, Kehui] Ningbo Univ, Sch Med, Yinzhou Hosp, Gastroenterol Surg Dept, Ningbo, Zhejiang, Peoples R China.
   [Ma, Gang] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Gastroenterol, Huaian, Jiangsu, Peoples R China.
   [Chen, Jiande D. Z.] Johns Hopkins Ctr Neurogastroenterol, Div Gastroenterol & Hepatol, Baltimore, MD 21224 USA.
C3 Naval Medical University; Ningbo University; Ningbo University; Nanjing
   Medical University; Johns Hopkins University; Johns Hopkins Medicine
RP Zhu, L (corresponding author), Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China.; Chen, JDDZ (corresponding author), Ningbo Pace Translat Med Res Ctr, Ningbo, Zhejiang, Peoples R China.; Chen, JDDZ (corresponding author), Johns Hopkins Ctr Neurogastroenterol, Div Gastroenterol & Hepatol, Baltimore, MD 21224 USA.
EM czzhuliang@smmu.edu.cn; jchen184@jhmi.edu
RI Hu, Pingping/HLH-6587-2023
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NR 63
TC 45
Z9 57
U1 0
U2 37
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD JUL
PY 2018
VL 113
IS 7
BP 1026
EP 1035
DI 10.1038/s41395-018-0156-y
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GR3KF
UT WOS:000442487800019
PM 29925916
DA 2026-01-16
ER

PT J
AU Jin, Y
   Zhou, J
   Xu, FF
   Ren, ZQ
   Hu, J
   Zhang, C
   Ge, KW
   Liu, LY
AF Jin, Ying
   Zhou, Jie
   Xu, Fangfang
   Ren, Zeqin
   Hu, Jun
   Zhang, Cong
   Ge, Kaiwen
   Liu, Lanying
TI Electroacupuncture alleviates the transition from acute to chronic pain
   through the p38 MAPK/TNF-α signalling pathway in the spinal dorsal horn
SO ACUPUNCTURE IN MEDICINE
LA English
DT Article
DE electroacupuncture; hyperalgesic priming; p38 mitogen-activated protein
   kinase; tumour necrosis factor alpha; spinal dorsal horn
ID ACTIVATED PROTEIN-KINASE; NEUROPATHIC PAIN; TNF-ALPHA; MAP KINASE;
   RECEPTOR; RAT; CONTRIBUTES; EXPRESSION; PLASTICITY; ALLODYNIA
AB Background: Hyperalgesic priming (HP) is a model of the transition from acute to chronic pain. Electroacupuncture (EA) could inhibit pain development through the peripheral dorsal root ganglia; however, it is unclear whether it can mitigate the transition from acute to chronic pain by attenuating protein expression in the p38 MAPK (mitogen-activated protein kinase)/tumour necrosis factor alpha (TNF-alpha) pathway in the spinal dorsal horn. Aims: We aimed to determine whether EA could prevent the transition from acute to chronic pain by affecting the p38 MAPK/TNF-alpha pathway in the spinal dorsal horn in a rat model established using HP. Methods: We first randomly subdivided 30 male Sprague-Dawley (SD) rats into 5 groups (n = 6 per group): control (N), sham HP (Sham-HP), HP, HP + SB203580p38 MAPK (HP+SB203580), and HP + Lenalidomide (CC-5013) (HP+Lenalidomide). We then randomly subdivided a further 30 male SD rats into 5 groups (n = 6 per group): Sham-HP, HP, sham EA (Sham EA), EA (EA), and EA + U-46619 p38 MAPK agonist (EA+U-46619). We assessed the effects of EA on the mechanical paw withdrawal threshold and p38 MAPK/TNF-alpha expression in the spinal dorsal horn of rats subjected to chronic inflammatory pain. Results: Rats in the EA group had reduced p38 MAPK and TNF-alpha expression and had significantly reduced mechanical hyperalgesia compared with rats in the other groups. Conclusion: Our findings indicate that EA could increase the mechanical pain threshold in rats and inhibit the transition from acute pain to chronic pain. This mechanism could involve reduced p38 MAPK/TNF-alpha expression in the spinal dorsal horn.
C1 [Jin, Ying; Hu, Jun; Zhang, Cong; Ge, Kaiwen; Liu, Lanying] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Acupuncture & Rehabil, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Jin, Ying; Xu, Fangfang] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Hangzhou, Peoples R China.
   [Zhou, Jie] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou, Peoples R China.
   [Ren, Zeqin] Dali Univ, Affiliated Hosp 1, Dept Rehabil Tradit Chinese Med, Dali City, Peoples R China.
C3 Nanjing University of Chinese Medicine; Zhejiang University; Zhejiang
   Chinese Medical University; Dali University
RP Liu, LY (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Acupuncture & Rehabil, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM bluelany@163.com
RI liu, lanying/ODL-0836-2025; fangfang, xu/LFS-5200-2024
OI Jin, Ying/0000-0001-9731-2307; 
FU Natural Science Foundation of Zhejiang Province [LQ21H270008,
   LQ18H270001]; Zhejiang Province Top Discipline of Chinese Medicine
   [ZTK2017A03, ZTK2017A04]
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This work was
   supported by the Natural Science Foundation of Zhejiang Province
   (LQ21H270008, LQ18H270001). The study was financially sponsored by
   Zhejiang Province Top Discipline of Chinese Medicine (No. ZTK2017A03,
   No. ZTK2017A04).
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EF